DK2890711T3 - Process for Preparation of Inter-species, Intra-Target Cross-Reactivity Antibody Molecules - Google Patents
Process for Preparation of Inter-species, Intra-Target Cross-Reactivity Antibody Molecules Download PDFInfo
- Publication number
- DK2890711T3 DK2890711T3 DK13753659.5T DK13753659T DK2890711T3 DK 2890711 T3 DK2890711 T3 DK 2890711T3 DK 13753659 T DK13753659 T DK 13753659T DK 2890711 T3 DK2890711 T3 DK 2890711T3
- Authority
- DK
- Denmark
- Prior art keywords
- species
- human
- antibodies
- antigen
- target
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261695664P | 2012-08-31 | 2012-08-31 | |
| PCT/EP2013/067979 WO2014033252A1 (en) | 2012-08-31 | 2013-08-30 | Method for producing antibody molecules having inter-species, intra-target cross-reactivity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2890711T3 true DK2890711T3 (en) | 2017-02-27 |
Family
ID=49080903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13753659.5T DK2890711T3 (en) | 2012-08-31 | 2013-08-30 | Process for Preparation of Inter-species, Intra-Target Cross-Reactivity Antibody Molecules |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20150203840A1 (cg-RX-API-DMAC10.html) |
| EP (2) | EP2977386A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP6391574B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN104583238A (cg-RX-API-DMAC10.html) |
| AU (2) | AU2013310924B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2878712A1 (cg-RX-API-DMAC10.html) |
| DK (1) | DK2890711T3 (cg-RX-API-DMAC10.html) |
| IL (1) | IL236523B (cg-RX-API-DMAC10.html) |
| IN (1) | IN2015DN00140A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2014033252A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013021562B1 (pt) | 2011-03-16 | 2023-01-10 | Argenx Bvba | Anticorpos para cd70 |
| AU2014298373B2 (en) | 2013-08-01 | 2019-12-05 | Ludwig Institute For Cancer Research Ltd | Anti-GARP protein and uses thereof |
| US10391168B1 (en) | 2014-08-22 | 2019-08-27 | University Of Bern | Anti-CD70 combination therapy |
| WO2018007999A1 (en) | 2016-07-08 | 2018-01-11 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
| GB201612337D0 (en) | 2016-07-15 | 2016-08-31 | Argen-X N V | Ant-il-22r antibodies |
| WO2018193427A1 (en) | 2017-04-21 | 2018-10-25 | Staten Biotechnology B.V. | Anti-apoc3 antibodies and methods of use thereof |
| GB201707561D0 (en) | 2017-05-11 | 2017-06-28 | Argenx Bvba | GARP-TGF-beta antibodies |
| CN111315772A (zh) | 2017-10-31 | 2020-06-19 | 斯塔顿生物技术有限公司 | 抗apoc3抗体及其使用方法 |
| MX2020006213A (es) | 2017-12-12 | 2020-09-14 | Pionyr Immunotherapeutics Inc | Anticuerpos anti-trem2 y metodos relacionados. |
| GB201800649D0 (en) | 2018-01-16 | 2018-02-28 | Argenx Bvba | CD70 Combination Therapy |
| US12037382B2 (en) | 2018-02-05 | 2024-07-16 | Stichting Vu | Inverse agonistic anti-US28 antibodies |
| WO2020080941A1 (en) | 2018-10-16 | 2020-04-23 | Umc Utrecht Holding B.V. | Anti- low-density lipoprotein receptor-related protein 5/6 antibodies |
| WO2021241730A1 (ja) * | 2020-05-29 | 2021-12-02 | 第一三共株式会社 | 炎症性腸疾患に対する治療用抗体 |
| WO2022154664A1 (en) | 2021-01-15 | 2022-07-21 | Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis | Inducers of senescence, in combination with a selective death receptor 5 (dr5) agonist, for use in a method of treating cancer |
| EP4612180A1 (en) | 2022-10-31 | 2025-09-10 | Stichting Amsterdam UMC | Single domain anti-cd169 antibodies |
| US20260176369A1 (en) | 2022-11-08 | 2026-06-25 | Stichting Amsterdam UMC | Activation Inducible Antigen Receptors for Adoptive Immunotherapy |
| EP4631501A1 (en) | 2024-04-09 | 2025-10-15 | Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis | Combinations of a calcium homeostasis disruptor with a death receptor 5 agonist for treating cancer |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999029888A1 (en) * | 1997-12-05 | 1999-06-17 | The Scripps Research Institute | Humanization of murine antibody |
| CN1735629B (zh) * | 2002-11-08 | 2012-05-09 | 埃博灵克斯股份有限公司 | 针对肿瘤坏死因子-α的单结构域抗体及其用途 |
| NZ540194A (en) * | 2002-11-08 | 2008-07-31 | Ablynx Nv | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| CN1798768B (zh) * | 2003-03-24 | 2013-05-08 | 津莫吉尼蒂克斯公司 | 抗il-22ra抗体和结合伴侣及其应用 |
| DE602004028347D1 (de) * | 2003-03-24 | 2010-09-09 | Zymogenetics Inc | Anti-il-22ra antikörper und bindungspartner und verwendungsmethoden bei entzündung |
| ES2335232T3 (es) * | 2005-06-21 | 2010-03-23 | Xoma Technology Ltd. | Anticuerpos y fragmentos de los mismos que se unen a la il-1 beta. |
| TWI417301B (zh) * | 2006-02-21 | 2013-12-01 | Wyeth Corp | 對抗人類介白素-２２（ｉｌ-２２）之抗體及其用途 |
| GB2461546B (en) * | 2008-07-02 | 2010-07-07 | Argen X Bv | Antigen binding polypeptides |
| US8444976B2 (en) | 2008-07-02 | 2013-05-21 | Argen-X B.V. | Antigen binding polypeptides |
| CA2781682A1 (en) * | 2009-12-04 | 2011-06-09 | Genentech, Inc. | Multispecific antibodies, antibody analogs, compositions, and methods |
| GB2476681B (en) | 2010-01-04 | 2012-04-04 | Argen X Bv | Humanized camelid VH, VK and VL immunoglobulin domains |
| GB201002238D0 (en) * | 2010-02-10 | 2010-03-31 | Affitech As | Antibodies |
| MX385858B (es) * | 2010-11-24 | 2025-03-18 | Lexicon Pharmaceuticals Inc | Anticuerpos que se unen a notum pectinacetilesterasa. |
-
2013
- 2013-08-30 AU AU2013310924A patent/AU2013310924B2/en active Active
- 2013-08-30 WO PCT/EP2013/067979 patent/WO2014033252A1/en not_active Ceased
- 2013-08-30 JP JP2015529031A patent/JP6391574B2/ja active Active
- 2013-08-30 EP EP15181968.7A patent/EP2977386A1/en not_active Withdrawn
- 2013-08-30 US US14/420,039 patent/US20150203840A1/en not_active Abandoned
- 2013-08-30 CA CA2878712A patent/CA2878712A1/en not_active Abandoned
- 2013-08-30 EP EP13753659.5A patent/EP2890711B1/en active Active
- 2013-08-30 CN CN201380044710.8A patent/CN104583238A/zh active Pending
- 2013-08-30 DK DK13753659.5T patent/DK2890711T3/en active
- 2013-08-30 IN IN140DEN2015 patent/IN2015DN00140A/en unknown
-
2014
- 2014-12-31 IL IL236523A patent/IL236523B/en active IP Right Grant
-
2017
- 2017-06-21 AU AU2017204188A patent/AU2017204188A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014033252A1 (en) | 2014-03-06 |
| CN104583238A (zh) | 2015-04-29 |
| EP2977386A1 (en) | 2016-01-27 |
| EP2890711B1 (en) | 2017-01-04 |
| AU2013310924A8 (en) | 2015-04-30 |
| AU2017204188A1 (en) | 2017-07-13 |
| IL236523B (en) | 2018-12-31 |
| AU2013310924B2 (en) | 2017-08-03 |
| US20150203840A1 (en) | 2015-07-23 |
| IL236523A0 (en) | 2015-02-26 |
| CA2878712A1 (en) | 2014-03-06 |
| IN2015DN00140A (cg-RX-API-DMAC10.html) | 2015-06-12 |
| EP2890711A1 (en) | 2015-07-08 |
| JP6391574B2 (ja) | 2018-09-26 |
| AU2013310924A1 (en) | 2015-01-29 |
| JP2015530087A (ja) | 2015-10-15 |
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