DK2872151T3 - Acellulære pro-tolerogene sammensætninger til behandling/forebyggelse af autoimmune sygdomme - Google Patents

Acellulære pro-tolerogene sammensætninger til behandling/forebyggelse af autoimmune sygdomme Download PDF

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Publication number
DK2872151T3
DK2872151T3 DK13817292T DK13817292T DK2872151T3 DK 2872151 T3 DK2872151 T3 DK 2872151T3 DK 13817292 T DK13817292 T DK 13817292T DK 13817292 T DK13817292 T DK 13817292T DK 2872151 T3 DK2872151 T3 DK 2872151T3
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prevention
treatment
autoimmune diseases
acellular pro
tolerogenic compositions
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DK13817292T
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Mark D Scott
Wendy M Toyofuku
Duncheng Wang
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Canadian Blood Services
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
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    • A61K39/0005Vertebrate antigens
    • A61K39/0008Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/001Preparations to induce tolerance to non-self, e.g. prior to transplantation
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    • A61K39/462Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
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    • A61K39/4643Vertebrate antigens
    • A61K39/46433Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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    • A61K2039/577Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
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    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
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    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
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DK13817292T 2012-07-12 2013-07-12 Acellulære pro-tolerogene sammensætninger til behandling/forebyggelse af autoimmune sygdomme DK2872151T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261670694P 2012-07-12 2012-07-12
US201261670636P 2012-07-12 2012-07-12
CA2782942A CA2782942C (en) 2012-07-12 2012-07-12 Method for inducing immune tolerance using polymer-modified antigenic leukocytes
PCT/CA2013/050544 WO2014008609A1 (en) 2012-07-12 2013-07-12 Acellular pro-tolerogenic compositions for the treatment/prevention of auto-immune diseases

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DK2872151T3 true DK2872151T3 (da) 2019-12-02

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Family Applications (3)

Application Number Title Priority Date Filing Date
DK13817292T DK2872151T3 (da) 2012-07-12 2013-07-12 Acellulære pro-tolerogene sammensætninger til behandling/forebyggelse af autoimmune sygdomme
DK13817560.9T DK2872153T3 (da) 2012-07-12 2013-07-12 Accellulære pro-tolerogene sammensætninger og fremgangsmåde til fremstilling heraf
DK13817327T DK2872152T3 (da) 2012-07-12 2013-07-12 Acellulære pro-tolerogene sammensætninger til behandling/forebyggelse af transplantatafstødning

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DK13817560.9T DK2872153T3 (da) 2012-07-12 2013-07-12 Accellulære pro-tolerogene sammensætninger og fremgangsmåde til fremstilling heraf
DK13817327T DK2872152T3 (da) 2012-07-12 2013-07-12 Acellulære pro-tolerogene sammensætninger til behandling/forebyggelse af transplantatafstødning

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US (6) US10039787B2 (da)
EP (5) EP2872153B1 (da)
CA (6) CA2782942C (da)
DK (3) DK2872151T3 (da)
WO (5) WO2014008609A1 (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
WO2010138919A2 (en) 2009-05-28 2010-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
EP2627274B1 (en) 2010-10-13 2022-12-14 AngioDynamics, Inc. System for electrically ablating tissue of a patient
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
CA2782942C (en) 2012-07-12 2019-08-27 Canadian Blood Services Method for inducing immune tolerance using polymer-modified antigenic leukocytes
EP3019176B1 (en) * 2013-07-12 2020-05-06 Canadian Blood Services Use of acellular pro-inflammatory compositions and process for making same
WO2015157678A2 (en) * 2014-04-10 2015-10-15 The Trustees Of The University Of Pennsylvania Use of micro-ribonucleic acid (mirna) to diagnose transplant rejection and tolerance of immunosuppression therapy
US10471254B2 (en) 2014-05-12 2019-11-12 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
CA2954440A1 (en) 2014-07-10 2016-01-14 Canadian Blood Services Combination therapy of acellular pro-tolerogenic and pro-inflammatory preparations for modulating the immune system
WO2016100325A1 (en) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
CN108642175B (zh) * 2018-08-17 2022-05-17 广西医科大学第一附属医院 早期胚胎停育绒毛组织miRNAs生物标志物及其表达量的检测方法
EP3852868A4 (en) * 2018-09-18 2022-06-15 Virginia Tech Intellectual Properties, Inc. TREATMENT PLANNING SYSTEM FOR IMMUNOTHERAPY USING NON-THERMAL ABLATION
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277635B1 (en) * 1992-03-04 2001-08-21 Schering Corporation Use of interleukin-10 to produce a population of suppressor cells
US5908624A (en) 1996-06-27 1999-06-01 Albany Medical College Antigenic modulation of cells
CA2279978A1 (en) 1996-02-01 1997-08-07 Si-Myung Byun Antigenic modulation of cells
US8007784B1 (en) 1996-06-27 2011-08-30 Albany Medical College Antigenic modulation of cells
ES2270507T3 (es) 1997-03-07 2007-04-01 Jimro Co., Ltd. Inductores de inmunotolerancia.
EP1241249A1 (en) 2001-03-12 2002-09-18 Gerold Schuler CD4+CD25+regulatory T cells from human blood
US7651855B2 (en) 2003-04-17 2010-01-26 The Trustees Of The University Of Pennsylvania Regulatory T cells and their use in immunotherapy and suppression of autoimmune responses
US7435592B2 (en) * 2003-05-13 2008-10-14 Immunovative Therapies, Ltd. Compositions for allogeneic cell therapy
US20070009497A1 (en) 2004-03-10 2007-01-11 Steinman Ralph M Dendritic cell expanded T suppressor cells and methods of use thereof
US9273282B2 (en) * 2004-09-15 2016-03-01 The Trustees Of The University Of Pennsylvania Methods for the isolation and expansion of cord blood derived T regulatory cells
ES2482141T3 (es) 2006-04-13 2014-08-01 Immunovative Therapies, Ltd. Terapia con células alogénicas para el tratamiento de una infección oportunista
US8067151B2 (en) 2007-02-09 2011-11-29 Canadian Blood Services Cold storage of pegylated platelets at about or below 0° C.
EP2096171A1 (en) * 2008-02-27 2009-09-02 Julius-Maximilians-Universität Würzburg MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes
EP2416789B1 (en) 2009-04-07 2017-06-21 Velin-Pharma A/S Method and device for treatment of conditions associated with inflammation or undesirable activation of the immune system
US9211321B2 (en) 2009-10-27 2015-12-15 Immunicum Ab Method for proliferation of antigen-specific T cells
EP2638159B1 (en) 2010-11-11 2019-04-24 University of Miami Compositions, kits and methods for treatment of cardiovascular, immunological, and inflammatory diseases
JP2014526472A (ja) 2011-09-08 2014-10-06 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 免疫応答を調節するための材料および方法
CA2782942C (en) 2012-07-12 2019-08-27 Canadian Blood Services Method for inducing immune tolerance using polymer-modified antigenic leukocytes
EP3019176B1 (en) 2013-07-12 2020-05-06 Canadian Blood Services Use of acellular pro-inflammatory compositions and process for making same

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US20150164948A1 (en) 2015-06-18
EP2872152A4 (en) 2016-04-13
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US20150174168A1 (en) 2015-06-25
EP2872150A1 (en) 2015-05-20
US20140017218A1 (en) 2014-01-16
EP2872149A4 (en) 2016-04-06
CA2878604A1 (en) 2014-01-16
US20150202229A1 (en) 2015-07-23
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EP2872153B1 (en) 2019-02-27
CA2878726A1 (en) 2014-01-16
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US10039786B2 (en) 2018-08-07
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