DK283881A - Fremgangsmaade til fremstilling af pyrazinyl1,2,4-oxadiazol-5-oner - Google Patents
Fremgangsmaade til fremstilling af pyrazinyl1,2,4-oxadiazol-5-onerInfo
- Publication number
- DK283881A DK283881A DK283881A DK283881A DK283881A DK 283881 A DK283881 A DK 283881A DK 283881 A DK283881 A DK 283881A DK 283881 A DK283881 A DK 283881A DK 283881 A DK283881 A DK 283881A
- Authority
- DK
- Denmark
- Prior art keywords
- preparing
- pyrazinyl1
- oner
- oxadiazol
- procedure
- Prior art date
Links
- ALYSDVMPAXWPNM-UHFFFAOYSA-N 3-pyrazin-2-yl-2h-1,2,4-oxadiazol-5-one Chemical class N1OC(=O)N=C1C1=CN=CC=N1 ALYSDVMPAXWPNM-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Photoreceptors In Electrophotography (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/163,614 US4309430A (en) | 1980-06-27 | 1980-06-27 | Pyrazinyl-1,2,4-oxadiazole-5-ones, for treatment of edema, and processes for preparing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK283881A true DK283881A (da) | 1981-12-28 |
Family
ID=22590790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK283881A DK283881A (da) | 1980-06-27 | 1981-06-26 | Fremgangsmaade til fremstilling af pyrazinyl1,2,4-oxadiazol-5-oner |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4309430A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0043123B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPS5756480A (cg-RX-API-DMAC10.html) |
| AT (1) | ATE7697T1 (cg-RX-API-DMAC10.html) |
| DE (1) | DE3163867D1 (cg-RX-API-DMAC10.html) |
| DK (1) | DK283881A (cg-RX-API-DMAC10.html) |
| ES (1) | ES8300758A1 (cg-RX-API-DMAC10.html) |
| GR (1) | GR74609B (cg-RX-API-DMAC10.html) |
| IE (1) | IE51342B1 (cg-RX-API-DMAC10.html) |
| PT (1) | PT73259B (cg-RX-API-DMAC10.html) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5066662A (en) * | 1990-05-21 | 1991-11-19 | Warner-Lambert Company | Substituted oxazolidin-2-ones and 1,2,4-oxadiazolin-5-ones and derivatives thereof acting at muscarinic receptors |
| CA2743134A1 (en) | 2008-11-10 | 2010-05-14 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| BRPI0924084B1 (pt) | 2008-12-19 | 2021-12-21 | Vertex Pharmaceuticals Incorporated | Derivados de pirazina e composição farmacêutica que os compreende |
| JP2013526538A (ja) | 2010-05-12 | 2013-06-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｒキナーゼ阻害剤として有用な化合物 |
| US9334244B2 (en) | 2010-05-12 | 2016-05-10 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| JP2013526539A (ja) | 2010-05-12 | 2013-06-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｒキナーゼ阻害剤として有用なピラジン |
| EP2569284B1 (en) | 2010-05-12 | 2015-07-08 | Vertex Pharmaceuticals Incorporated | 2-aminopyridine derivatives useful as inhibitors of atr kinase |
| EP2569286B1 (en) | 2010-05-12 | 2014-08-20 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| WO2011143426A1 (en) | 2010-05-12 | 2011-11-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2011163527A1 (en) | 2010-06-23 | 2011-12-29 | Vertex Pharmaceuticals Incorporated | Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase |
| CN103562204A (zh) | 2011-04-05 | 2014-02-05 | 沃泰克斯药物股份有限公司 | 可用作tra激酶的抑制剂的氨基吡嗪化合物 |
| WO2012178125A1 (en) | 2011-06-22 | 2012-12-27 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2723747A1 (en) | 2011-06-22 | 2014-04-30 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| JP2014520161A (ja) | 2011-06-22 | 2014-08-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｒキナーゼ阻害剤として有用な化合物 |
| RU2018147217A (ru) | 2011-09-30 | 2019-01-18 | Вертекс Фармасьютикалз Инкорпорейтед | Способы получения соединений, которые можно использовать в качестве ингибиторов киназы atr |
| SG11201401095YA (en) | 2011-09-30 | 2014-04-28 | Vertex Pharma | Treating pancreatic cancer and non-small cell lung cancer with atr inhibitors |
| US8846686B2 (en) | 2011-09-30 | 2014-09-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| WO2013049720A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2013049719A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2776420A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Pyrazine compounds useful as inhibitors of atr kinase |
| US8841449B2 (en) | 2011-11-09 | 2014-09-23 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| WO2013071088A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2013071090A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2013071094A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| RS56673B1 (sr) | 2012-04-05 | 2018-03-30 | Vertex Pharma | Jedinjenja korisna kao inhibitori atr kinaze i kombinovane terapije koje ih koriste |
| EP2904406B1 (en) | 2012-10-04 | 2018-03-21 | Vertex Pharmaceuticals Incorporated | Method for measuring atr inhibition mediated increases in dna damage |
| EP2909202A1 (en) | 2012-10-16 | 2015-08-26 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| CN107501275B (zh) | 2012-12-07 | 2019-11-22 | 沃泰克斯药物股份有限公司 | 可用作atr激酶抑制剂的化合物 |
| US9663519B2 (en) | 2013-03-15 | 2017-05-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| PT3077397T (pt) | 2013-12-06 | 2020-01-22 | Vertex Pharma | Composto de 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]pirazolo[1,5-a]pirimidin-3-carboxamida útil como inibidor da atr quinase, a sua preparação, diferentes formas sólidas e derivados radiomarcados do mesmo |
| JP6568111B2 (ja) | 2014-06-05 | 2019-08-28 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | ＡＴＲキナーゼ阻害剤として有用な２−アミノ−６−フルオロ−Ｎ−［５−フルオロ−ピリジン−３−イル］ピラゾロ［１，５−ａ］ピリミジン−３−カルボキサミド化合物の放射性標識された誘導体、この化合物およびその異なる固体形態の調製 |
| HRP20191375T1 (hr) | 2014-06-17 | 2019-11-01 | Vertex Pharma | Postupak liječenja raka upotrebom kombinacije chk1 i atr inhibitora |
| RU2768621C1 (ru) | 2015-09-30 | 2022-03-24 | Вертекс Фармасьютикалз Инкорпорейтед | Способ лечения рака с использованием комбинации повреждающих днк средств и ингибиторов atr |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3515723A (en) * | 1967-11-14 | 1970-06-02 | Merck & Co Inc | 2 - (5 - amino - 1h - 1,2,4 - triazol - 3 - yl)- 3-aminopyrazines and processes for their preparation |
| US3770739A (en) * | 1972-09-11 | 1973-11-06 | American Cyanamid Co | Cyclorpropyl-1,2,4-oxadiazolylpyrazines |
-
1980
- 1980-06-27 US US06/163,614 patent/US4309430A/en not_active Expired - Lifetime
-
1981
- 1981-06-22 GR GR65307A patent/GR74609B/el unknown
- 1981-06-23 ES ES503308A patent/ES8300758A1/es not_active Expired
- 1981-06-25 PT PT73259A patent/PT73259B/pt unknown
- 1981-06-26 IE IE1431/81A patent/IE51342B1/en unknown
- 1981-06-26 AT AT81104974T patent/ATE7697T1/de active
- 1981-06-26 DK DK283881A patent/DK283881A/da not_active Application Discontinuation
- 1981-06-26 EP EP81104974A patent/EP0043123B1/en not_active Expired
- 1981-06-26 DE DE8181104974T patent/DE3163867D1/de not_active Expired
- 1981-06-26 JP JP56098426A patent/JPS5756480A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| GR74609B (cg-RX-API-DMAC10.html) | 1984-06-29 |
| EP0043123B1 (en) | 1984-05-30 |
| PT73259B (en) | 1983-06-28 |
| ATE7697T1 (de) | 1984-06-15 |
| JPS5756480A (en) | 1982-04-05 |
| IE51342B1 (en) | 1986-12-10 |
| PT73259A (en) | 1981-07-01 |
| IE811431L (en) | 1981-12-27 |
| DE3163867D1 (en) | 1984-07-05 |
| ES503308A0 (es) | 1982-11-01 |
| EP0043123A1 (en) | 1982-01-06 |
| ES8300758A1 (es) | 1982-11-01 |
| US4309430A (en) | 1982-01-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK283881A (da) | Fremgangsmaade til fremstilling af pyrazinyl1,2,4-oxadiazol-5-oner | |
| NO152552C (no) | Fremgangsmaate til behandling av problemavfall. | |
| BG37375A3 (bg) | Метод за получаване на пролиннови производни | |
| DK503082A (da) | Fremgangsmaade til fremstilling af 3-(1-substitueret-4-piperidyl)-1,2-benzisoxazoler | |
| BG31799A3 (bg) | Метод за получаване на хидантоини | |
| BG38487A3 (en) | Method for preparing peptides | |
| DK498080A (da) | Fremgangsmaade til fremstilling af 4!-epidaunorubicin, 3!,4!-diepidaunorubicin og disses doxorubicinanaloge | |
| NO794265L (no) | Fremgangsmaate til behandling av problemavfall. | |
| DK267979A (da) | Fremgangsmaade til fremstilling af aryloxypropanolaminer | |
| BG34907A3 (en) | Method for preparing benzodiazepine compounds | |
| ATE12180T1 (de) | Dragierverfahren. | |
| DK163379A (da) | Fremgangsmaade til fremstilling af substituerede 1,3-diaryl-2-imino-imidazolidiner og 2-imino-hexahydro-pyrimidiner | |
| DK67683D0 (da) | Fremgangsmade til fremstilling af 2,3-diaryl-5-halogen-thio-phener | |
| ES524439A0 (es) | Procedimiento de obtencion de los 2-amino 5- (aralcoil piperidino alcoil) amino 1,4-diazoles | |
| NO803849L (no) | Fremgangsmaate til behandling av problemavfall | |
| BG36935A3 (en) | Method for preparing benzodiazepine compounds | |
| DK585984A (da) | 1,7-diphenyl-3-methylaza-7-cyan-8-methyl-nonan og salte deraf til anvendelse ved bekaempelse af sygdomme samt fremgangsmaade til fremstilling af saadanne nonanderivater | |
| BG35032A3 (bg) | Метод за получаване на 1, 1, 2- трифенилпропенови производни | |
| DK192890D0 (da) | 24r-scumnol, fremgangsmaade til fremstilling heraf samt anvendelse af samme | |
| BG35041A3 (bg) | Метод за получаване на заместени 2-пиперидин-4-амино-6,7- диметоксихиназолини | |
| DK161067C (da) | Analogifremgangsmaade til fremstilling af 1,8-dihydroxy-9-anthron-addukter | |
| FR2479220B1 (cg-RX-API-DMAC10.html) | ||
| DK158142C (da) | Fremgangsmaade til beskyttelse af trae og traebeskyttelsesmiddel til anvendelse derved | |
| DK353783D0 (da) | Fremgangsmade til fremstilling af 0,s-dimethylthiolophosphorsyreamid | |
| DE3576498D1 (de) | 2-sulfamoyl-1h-indole-derivate zur behandlung von hohem intraocularem druck. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |