DK2823040T3 - DEVICES AND METHODS FOR SELECTING APOPTOSE SIGNALING RESISTANT CELLS AND APPLICATIONS THEREOF - Google Patents

DEVICES AND METHODS FOR SELECTING APOPTOSE SIGNALING RESISTANT CELLS AND APPLICATIONS THEREOF Download PDF

Info

Publication number
DK2823040T3
DK2823040T3 DK13758162.5T DK13758162T DK2823040T3 DK 2823040 T3 DK2823040 T3 DK 2823040T3 DK 13758162 T DK13758162 T DK 13758162T DK 2823040 T3 DK2823040 T3 DK 2823040T3
Authority
DK
Denmark
Prior art keywords
cells
cell
apoptosis
fasl
tnf
Prior art date
Application number
DK13758162.5T
Other languages
Danish (da)
English (en)
Inventor
Shai Yarkoni
Nadir Askenasy
Original Assignee
Cellect Biotherapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellect Biotherapeutics Ltd filed Critical Cellect Biotherapeutics Ltd
Application granted granted Critical
Publication of DK2823040T3 publication Critical patent/DK2823040T3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081Purging biological preparations of unwanted cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/51Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/25Tumour necrosing factors [TNF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/599Cell markers; Cell surface determinants with CD designations not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
DK13758162.5T 2012-03-06 2013-03-05 DEVICES AND METHODS FOR SELECTING APOPTOSE SIGNALING RESISTANT CELLS AND APPLICATIONS THEREOF DK2823040T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261607033P 2012-03-06 2012-03-06
PCT/IL2013/000026 WO2013132477A1 (en) 2012-03-06 2013-03-05 Devices and methods for selecting apoptosis-signaling resistant cells, and uses thereof

Publications (1)

Publication Number Publication Date
DK2823040T3 true DK2823040T3 (en) 2018-11-19

Family

ID=49116028

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13758162.5T DK2823040T3 (en) 2012-03-06 2013-03-05 DEVICES AND METHODS FOR SELECTING APOPTOSE SIGNALING RESISTANT CELLS AND APPLICATIONS THEREOF

Country Status (11)

Country Link
US (2) US9783778B2 (https=)
EP (2) EP2823040B1 (https=)
JP (1) JP6429191B2 (https=)
KR (1) KR101912982B1 (https=)
CN (2) CN109116033A (https=)
AU (1) AU2013229008B2 (https=)
CA (1) CA2866358C (https=)
DK (1) DK2823040T3 (https=)
IL (1) IL234459B (https=)
RU (1) RU2630301C2 (https=)
WO (1) WO2013132477A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3054961B1 (en) * 2013-10-09 2020-08-26 Cellect Biotherapeutics Ltd. Activation of hematopoietic progenitors by pretransplant exposure to death ligands
WO2016193986A2 (en) 2015-06-05 2016-12-08 Cellect Biotherapeutics Ltd. Selective surfaces for, and methods of, selecting a population of stem and progenitor cells, and uses thereof
EP3841196A4 (en) * 2018-08-22 2022-09-21 Cellect Biotherapeutics Ltd. MODULATION OF CELLS RESPONSIVE TO APOPTOSIS
US20220002363A1 (en) * 2020-07-03 2022-01-06 United States Government As Represented By The Department Of Veterans Affairs Compositions and methods for treating pulmonary disease

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
JPS61235752A (ja) 1985-04-11 1986-10-21 Asahi Optical Co Ltd 細胞分離材、分離器および分離方法
IT8523298V0 (it) * 1985-10-02 1985-10-02 Pierrel Hospital Spa Catetere venoso centrale.
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US4979959A (en) 1986-10-17 1990-12-25 Bio-Metric Systems, Inc. Biocompatible coating for solid surfaces
US4885234A (en) 1988-09-29 1989-12-05 Eastman Kodak Company Photographic materials containing stable cyan coupler formulations
US5998024A (en) 1995-02-02 1999-12-07 Rainer H. Frey Biocompatible material and method of manufacture and use thereof
HUP0003349A3 (en) 1997-05-14 2001-12-28 Aventis Pharmaceuticals Inc Co Peptide parathyroid hormone analogs, pharmaceutical compositions comprising thereof and their use
US6040182A (en) 1997-11-12 2000-03-21 Becton Dickinson And Company Method and materials for efficiency protein immobilization on tissue culture treated assay plates
GB9724270D0 (en) 1997-11-17 1998-01-14 Babraham The Inst Methods and means for mutagenesis of dna
DE69900984T2 (de) 1998-04-22 2002-10-31 St. Jude Medical Ab, Jaerfaella Biokompatibles material für implantate
US20010049115A1 (en) * 2000-01-17 2001-12-06 Collins John Kevin Vitro model for gastrointestinal inflammation
US20090130718A1 (en) 1999-02-04 2009-05-21 Diversa Corporation Gene site saturation mutagenesis
US20030119185A1 (en) * 2000-02-24 2003-06-26 Xcyte Therapies, Inc. Activation and expansion of cells
WO2003002761A1 (en) 2001-06-29 2003-01-09 Novozymes A/S Method of multimerization and site-directed mutagenesis
JP2005514617A (ja) * 2001-07-02 2005-05-19 ザ、ボード、オブ、トラスティーズ、オブ、ザ、リーランド、スタンフォード、ジュニア、ユニバーシティ 細胞の表現型決定および操作のためのマイクロアレイ
EP1281767A3 (en) 2001-07-31 2003-05-28 Aladar A. Szalay Light emitting microorganisms and cells for diagnosis and therapy of tumors
DE10144252A1 (de) * 2001-08-31 2003-03-27 Fraunhofer Ges Forschung Nanopartikel mit daran immobilisiertem biologisch aktivem TNF
WO2003106692A2 (en) * 2002-06-13 2003-12-24 Merck Patent Gmbh Methods for the identification of all-antigens and their use for cancer therapy and transplantation
DE60334474D1 (de) * 2002-07-12 2010-11-18 Univ Johns Hopkins Reagenzien und verfahren zum eingriff in einzigartige klonotype lymphozyten-rezeptoren
US20060009623A1 (en) 2004-07-06 2006-01-12 National University Of Singapore C-terminal attachment of ligands to proteins for immobilization onto a support
AU2005291298B2 (en) * 2004-10-01 2012-01-19 Apoxis Sa Method for ex-vivo purging in autologous transplantation
ZA200704252B (en) * 2004-10-25 2009-09-30 Cellerant Therapeutics Inc Methods of expanding myeloid cell populations and uses thereof
DE602005008265D1 (de) * 2005-12-23 2008-08-28 Biedermann Motech Gmbh Flexible Stabilisierungsvorrichtung zur dynamischen Stabilisierung von Knochen oder Wirbeln
CN101517070A (zh) * 2006-05-31 2009-08-26 Styx有限责任公司 选择干细胞的方法及其用途
WO2007138597A2 (en) * 2006-05-31 2007-12-06 Styx Llc Methods of selecting stem cells and uses thereof
CN101711360A (zh) * 2007-03-16 2010-05-19 赛乐思迪斯有限公司 细胞介导的免疫应答检验及其试剂盒
KR100920729B1 (ko) 2007-10-01 2009-10-07 한국생명공학연구원 펩타이드 혼성체를 사용한 배향성이 조절된 항체단분자막의 제조방법
US20100040583A1 (en) 2008-03-27 2010-02-18 Vincent Falanga Compositions and methods using stem cells in cutaneous wound healing
EP2274617A4 (en) * 2008-04-10 2011-11-09 Massachusetts Inst Technology METHOD OF DETECTING AND USING MEDIUM-TREATMENT AID ON CANCER STEM CELLS
AU2009257230B2 (en) 2008-06-13 2015-05-28 Smith & Nephew, Inc. Fixation devices for tissue repair
CN104357381A (zh) * 2008-10-31 2015-02-18 辛西斯有限责任公司 用于活化干细胞的方法和装置
GB0823553D0 (en) 2008-12-24 2009-01-28 Immunosolv Ltd Cell separation technique
JP2010227313A (ja) * 2009-03-27 2010-10-14 Seiko Epson Corp がん細胞除去システムおよびがん細胞除去装置
JP5327457B2 (ja) * 2009-03-27 2013-10-30 セイコーエプソン株式会社 がん細胞分離装置およびその製造方法
WO2012011113A2 (en) * 2010-07-22 2012-01-26 Shai Yarkoni Regulatory immune cells with enhanced targeted cell death effect

Also Published As

Publication number Publication date
AU2013229008B2 (en) 2018-11-08
CA2866358A1 (en) 2013-09-12
EP3486315A1 (en) 2019-05-22
US9783778B2 (en) 2017-10-10
US20150044182A1 (en) 2015-02-12
JP6429191B2 (ja) 2018-11-28
EP2823040B1 (en) 2018-08-01
RU2014138001A (ru) 2016-04-20
WO2013132477A1 (en) 2013-09-12
JP2015510758A (ja) 2015-04-13
CN109116033A (zh) 2019-01-01
RU2630301C2 (ru) 2017-09-06
IL234459B (en) 2020-02-27
KR20150011796A (ko) 2015-02-02
EP2823040A1 (en) 2015-01-14
CN104245924A (zh) 2014-12-24
CA2866358C (en) 2020-06-23
KR101912982B1 (ko) 2018-10-29
US20180208888A1 (en) 2018-07-26
EP2823040A4 (en) 2016-01-06
AU2013229008A1 (en) 2014-09-18
CN104245924B (zh) 2020-05-01

Similar Documents

Publication Publication Date Title
KR101518409B1 (ko) 단핵세포 증량 방법
AU2005206746B2 (en) Regulatory t cells suppress autoimmunity
Boieri et al. The role of animal models in the study of hematopoietic stem cell transplantation and GvHD: a historical overview
CN103930130A (zh) 抗第三方中央型记忆t细胞、其产生方法以及其在移植和疾病治疗中的应用
US20180208888A1 (en) Devices and methods for selecting apoptosis-signaling resistant cells, and uses thereof
Young et al. Erosion of transplantation tolerance after infection
Gail et al. Complex interactions of cellular players in chronic Graft-versus-Host Disease
Zhang et al. The role and potential therapeutic application of myeloid‐derived suppressor cells in allo‐and autoimmunity
EP3303563B1 (en) Selective surfaces for, and methods of, selecting a population of stem and progenitor cells, and uses thereof
WO2022122961A1 (en) Use of mait cells for controlling graft versus host disease
Zorina New Insights on the Role of the Mesenchymal–Hematopoietic Stem Cell Axis in Autologous and Allogeneic Hematopoiesis
Zimmerman et al. Cytolytic pathways used by effector cells derived from recipient naive and memory T cells and natural killer cells in resistance to allogeneic hematopoietic cell transplantation
Puga et al. B–helper neutrophils stimulate immunoglobulin diversification and production in the marginal zone of the spleen
Jones The immunobiology of graft-versus-host disease across a minor histocompatibility antigen barrier
Barnkob Role of neuropilin-1 in CD8+ T cells
Collin et al. Human Langerhans cells in transplantation: Recipient cells survive conditioning but donor cells predominate at day 100
Miklos et al. Antibody response to HY minor histocompatibility antigens correlates with chronic graft versus host disease and disease remission
Riordan et al. Immune Privilege of Cord Blood
Collins Jr Allogeneic bone marrow transplantation
Ditschkowski et al. Favourable outcome of allogeneic haematopoietic stem cell transplantation (HSCT) for patients with myelofibrosis in non-advanced disease stages