DK2753316T3 - Farmaceutisk kombination omfattende et cip2a silencing-middel til anvendelse i behandlingen af en hyperproliferativ lidelse, fortrinsvis en med svækket p53-funktion - Google Patents
Farmaceutisk kombination omfattende et cip2a silencing-middel til anvendelse i behandlingen af en hyperproliferativ lidelse, fortrinsvis en med svækket p53-funktion Download PDFInfo
- Publication number
- DK2753316T3 DK2753316T3 DK12762321.3T DK12762321T DK2753316T3 DK 2753316 T3 DK2753316 T3 DK 2753316T3 DK 12762321 T DK12762321 T DK 12762321T DK 2753316 T3 DK2753316 T3 DK 2753316T3
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- DK
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- cip2a
- cancer
- group
- cells
- sirna
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Claims (9)
1. Kombination af mindst en type af et CIP2A silencing-middel valgt fra gruppen bestående af et siRNA-molekyle, DsiRNA-molekyle, kunstig miRNA-prækursor, shRNA-molekyle, antisense oligonukleotid, og ribozym; og mindst en type afen forbindelse valgt fra gruppen bestående af PKC-412, PARP-inhibitor III, indol-3-carbinol, cisplatin, rapamycin, TGX-221, NU-7441, S31-201, og gemcitabin, til anvendelse som et medikament i behandlingen afen hyperproliferativ lidelse omfattende celler med svækket p53-funktion.
2. Kombinationen til anvendelse ifølge krav 1, hvor CIP2A silencing-midlet omfatter en nukleinsyresekvens valgt fra gruppen bestående af SEQ ID NO:s 1 til 25, og sekvenser, der har mindst 80 % sekvensidentitet med nævnte SEQ ID NO:s 1 til 25 og der bibeholder deres CIP2A silencing-aktivitet.
3. Kombinationen til anvendelse ifølge krav 1, hvor den hyperproliferative sygdom er valgt fra en gruppe bestående af psoriasis, myokardial hypertrofi, godartede tumorer, faste cancere og hæmatologiske cancere.
4. Kombinationen til anvendelse ifølge krav 3, hvor nævnte faste cancer er valgt fra en gruppe bestående af pladeepithelcarcinomer i hovedet og halsen, koloncancer, gastrisk cancer, brystkræft, kræft i æggestokkene, prostatakræft, livmoderhalskræft, kræft i spiserøret, lungekræft, leverkræft, kræft i hjernen, gliom, astrocytom, og glioblastom og hæmatologiske cancere er valgt fra en gruppe bestående af akut og kronisk T-celle og B-celle leukæmi og lymfomer.
5. Farmaceutisk sammensætning omfattende en kombination defineret i et hvilket som helst af kravene 1 til 4 og mindst en farmaceutisk acceptabel bærer.
6. CIP2A silencing-middel valgt fra gruppen bestående af et siRNA-molekyle, DsiRNA-molekyle, kunstig miRNA-prækursor, shRNA-molekyle, antisense oligonukleotid, og ribozym til anvendelse i sensibilisering af hyperproliferative celler med svækket p53-funktion over for et kemoterapeutisk middel valgt fra gruppen bestående af PKC-412, PARP-inhibitor III, indol-3-carbinol, cisplatin, rapamycin, TGX-221, NU-7441, S31-201, og gemcitabin i et menneske- eller dyreindivid med behov for sådan sensibilisering til behandlingen af en hyperproliferativ sygdom.
7. Fremgangsmåde til at bestemme sensitiviteten over for en cancerterapi hos et individ med behov for sådan terapi, hvor fremgangsmåden omfatter at evaluere CIP2A og p53-udtryk og/eller proteinaktivitet i en prøve opnået fra nævnte individ, og at bestemme et individ, hvis prøve er negativ for CIP2A-udtryk og/eller -aktivitet og svækket for p53-aktivitet, som sensitiv over for cancermonoterapi med mindst et kemoterapeutisk middel, og at bestemme et individ, hvis prøve er positiv for CIP2A-udtryk og svækket for p53-aktivitet, som sensitiv over for kombinationen ifølge krav 1 som en cancerterapi.
8. Fremgangsmåden ifølge krav 7, hvor nævnte individ lider af en sygdom defineret i krav 3 eller 4.
9. Kit til udøvelse af fremgangsmåden ifølge krav 7 omfattende reagenser til at evaluere CIP2A- og p53-udtryk og/eller proteinaktivitet.
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FI20115876A FI20115876A0 (fi) | 2011-09-06 | 2011-09-06 | Yhdistelmähoito |
PCT/FI2012/050862 WO2013034806A1 (en) | 2011-09-06 | 2012-09-06 | Pharmaceutical combination comprising a cip2a silencing agent for use in the treatment of a hyperproliferative disorder, preferably one with impaired p53 function |
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US10793535B2 (en) | 2012-11-16 | 2020-10-06 | Calithera Biosciences, Inc. | Heterocyclic glutaminase inhibitors |
CN107027291B (zh) * | 2014-06-13 | 2020-10-30 | 卡利泰拉生物科技公司 | 用谷氨酰胺酶抑制剂的组合疗法 |
CN106999490A (zh) | 2014-08-07 | 2017-08-01 | 卡利泰拉生物科技公司 | 晶体形式的谷氨酰胺酶抑制剂 |
EP3359150A4 (en) | 2015-10-05 | 2019-11-06 | Calithera Biosciences, Inc. | COMBINATION THERAPY WITH GLUTAMINASE INHIBITORS AND IMMUNO-ONCOLOGICAL AGENTS |
CN105467119A (zh) * | 2015-11-28 | 2016-04-06 | 上海交通大学医学院附属第三人民医院 | 一种预测大肠癌细胞对p38MAPK激酶抑制剂敏感性的方法 |
US10787666B2 (en) * | 2016-12-14 | 2020-09-29 | Shanghaitech University | Compositions and methods for treating cancer by inhibiting PIWIL4 |
US20200108089A1 (en) * | 2017-03-19 | 2020-04-09 | Suzhou Sirnaomics Biopharmaceuticals Co., Ltd. | Gemcitabine Derivatives for Cancer Therapy |
WO2018183868A1 (en) * | 2017-03-31 | 2018-10-04 | Bioventures, Llc | Inhibitors of dna pk and uses thereof |
WO2019195959A1 (en) | 2018-04-08 | 2019-10-17 | Cothera Biosciences, Inc. | Combination therapy for cancers with braf mutation |
US20210180141A1 (en) * | 2018-08-13 | 2021-06-17 | Beijing Percans Oncology Co., Ltd. | Biomarkers for cancer therapy |
KR102436309B1 (ko) * | 2020-05-26 | 2022-08-25 | 연세대학교 산학협력단 | 암의 예방 또는 치료용 약학적 조성물 |
CN111549033B (zh) * | 2020-06-11 | 2021-02-12 | 南京市江宁医院 | 慢病毒感染人表皮角质细胞株及其构建方法和应用 |
CN113663075B (zh) * | 2021-09-14 | 2023-03-21 | 清华大学深圳国际研究生院 | Pcsk9抑制剂在制备治疗或辅助治疗肿瘤的药物中的应用 |
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CA2137822C (en) * | 1992-06-26 | 2009-01-20 | Arnold J. Levine | Method for detecting pre-cancerous or cancerous cells using p90 antibodies or probes |
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US20030190635A1 (en) | 2002-02-20 | 2003-10-09 | Mcswiggen James A. | RNA interference mediated treatment of Alzheimer's disease using short interfering RNA |
US20040019001A1 (en) | 2002-02-20 | 2004-01-29 | Mcswiggen James A. | RNA interference mediated inhibition of protein typrosine phosphatase-1B (PTP-1B) gene expression using short interfering RNA |
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US20080021198A1 (en) | 2005-10-12 | 2008-01-24 | Yigong Shi | Modulators of protein phosphatase 2A and PP2A methyl esterase |
US20090029966A1 (en) * | 2006-01-17 | 2009-01-29 | Abbott Laboratories | Combination therapy with parp inhibitors |
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JP6060164B2 (ja) | 2017-01-11 |
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