DK2697252T3 - Sammensætninger og fremgangsmåder til forøget ethanol produktion fra biomasse - Google Patents

Sammensætninger og fremgangsmåder til forøget ethanol produktion fra biomasse Download PDF

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DK2697252T3
DK2697252T3 DK12770605.9T DK12770605T DK2697252T3 DK 2697252 T3 DK2697252 T3 DK 2697252T3 DK 12770605 T DK12770605 T DK 12770605T DK 2697252 T3 DK2697252 T3 DK 2697252T3
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leu
xylose
gly
ala
val
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Holly J Jessen
Jian Yi
Joshua Lundorff
Hans Liao
Ana Negrete-Raymond
Pirkko Suominen
Aristos Aristidou
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Cargill Inc
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C12P7/08—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate
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    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
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    • C12P7/06—Ethanol, i.e. non-beverage
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    • C12P7/00—Preparation of oxygen-containing organic compounds
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01009—D-Xylulose reductase (1.1.1.9), i.e. xylitol dehydrogenase
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/0101—L-Xylulose reductase (1.1.1.10)
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    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01001—Transketolase (2.2.1.1)
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    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01002—Transaldolase (2.2.1.2)
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01016—Ribulokinase (2.7.1.16)
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01017—Xylulokinase (2.7.1.17)
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    • C12Y501/00—Racemaces and epimerases (5.1)
    • C12Y501/03—Racemaces and epimerases (5.1) acting on carbohydrates and derivatives (5.1.3)
    • C12Y501/03001—Ribulose-phosphate 3-epimerase (5.1.3.1)
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    • C12Y501/03004—L-Ribulose-5-phosphate 4-epimerase (5.1.3.4)
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    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/01—Intramolecular oxidoreductases (5.3) interconverting aldoses and ketoses (5.3.1)
    • C12Y503/01003—Arabinose isomerase (5.3.1.3)
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    • C12Y503/01005—Xylose isomerase (5.3.1.5)
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    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Claims (14)

1. Genetisk modificeret gærcelle der overudtrykker et xylose-transporter polypeptid omfattende en aminosyresekvens der har mindst 90% sekvensidentitet med en aminosyresekvens valgt fra gruppen bestående af SEQ ID NO:2 og SEQ ID NO:4.
2. Genetisk modificeret gærcelle ifølge krav 1, yderligere omfattende en aktiv arabinose fermenteringsvej, hvor cellen omfatter et eller flere exogene arabinose fermenteringsvej-gener valgt fra gruppen bestående af Al, RK, og RE gener.
3. Genetisk modificeret gærcelle ifølge et hvilket som helst af kravene 1 og 2, yderligere omfattende en aktiv xylose fermenteringsvej, hvor cellen omfatter et eller flere exogene xylose fermenteringsvej-gener valgt fra gruppen bestående af XI og XK gener.
4. Genetisk modificeret gærcelle ifølge et hvilket som helst af kravene 2 og 3, yderligere omfattende en aktiv ikke-oxidativ pentosephosphatvej, hvor cellen omfatter et eller flere exogene ikke-oxidativ pentosephosphatvej-gener valgt fra gruppen bestående af TKL og TAL gener.
5. Genetisk modificeret gærcelle ifølge krav 4, hvor cellen yderligere omfatter et eller flere exogene ikke-oxidativ pentosephosphatvej-gener valgt fra gruppen bestående af RPE og RKI gener.
6. Genetisk modificeret gærcelle ifølge et hvilket som helst af kravene 1,2, 3, 4 og 5, hvor gærcellen yderligere omfatter en deletion eller afbrydelse af et eller flere gener valgt fra gruppen bestående af AR/XR, arabitol 4-dehydrogenase, xylulose reduktase, og XDH gener.
7. Genetisk modificeret gærcelle ifølge et hvilket som helst af kravene 1,2, 3, 4, 5 og 6, hvor gærcellen yderligere omfatter en deletion eller afbrydelse af et eller flere gener valgt fra gruppen bestående af ALD og ADH gener.
8. Genetisk modificeret gærcelle ifølge et hvilket som helst af kravene 1,2, 3, 4, 5, 6 og 7, hvor gærcellen tilhører I. orientalis/P.fermentans kladen.
9. Genetisk modificeret gærcelle ifølge krav 8, hvor gærcellen er I. orientalis.
10. Fremgangsmåde omfattende en fremgangsmåde til fermentering, hvor en genetisk modificeret gærcelle ifølge et hvilket som helst af kravene 1,2, 3, 4, 5, 6 og 7 dyrkes i fermenteringsmedium omfattende xylose.
11. Fremgangsmåde ifølge krav 10 til produktion af ethanol fra et medium omfattende xylose omfattende dyrkning af en genetisk modificeret gærcelle ifølge et hvilket som helst af kravene 1, 2, 3, 4, 5, 6 og 7 i et medium omfattende xylose.
12. Fremgangsmåde til fermentering ifølge krav 11, hvor mediet omfatter mindst 10 g/L xylose fra et plante-biomasse hydrolysat.
13. Isoleret polynukleotid der koder for et polypeptid omfattende en aminosyresekvens der har mindst 90% sekvensidentitet med en aminosyresekvens valgt fra gruppen bestående af aminosyresekvenserne angivet i SEQ ID NO:2 og SEQ ID NO:4, hvor polypeptidet er i stand til at transportere xylose ind i en gærcelle.
14. Isoleret polypeptid omfattende en aminosyresekvens der har mindst 90% sekvensidentitet med en aminosyresekvens valgt fra gruppen bestående af aminosyresekvenserne angivet i SEQ ID NO:2 og SEQ ID NO:4, hvor polypeptidet er i stand til at transportere xylose ind i en gærcelle.
DK12770605.9T 2011-04-11 2012-04-11 Sammensætninger og fremgangsmåder til forøget ethanol produktion fra biomasse DK2697252T3 (da)

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PCT/US2012/033030 WO2012142094A2 (en) 2011-04-11 2012-04-11 Compositions and methods for increased ethanol production from biomass

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CA2832587A1 (en) 2012-10-18
US9181563B2 (en) 2015-11-10
US9862975B2 (en) 2018-01-09
US20140038253A1 (en) 2014-02-06
EP2697252B1 (en) 2016-08-10
ES2602808T3 (es) 2017-02-22
WO2012142094A3 (en) 2014-05-01
EP2697252A4 (en) 2015-05-06
WO2012142094A2 (en) 2012-10-18
US20160002676A1 (en) 2016-01-07

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