DK2612691T3 - Forskydningsresistent mikroelektrode, mikroelektrodebundt og mikroelektrodegruppe - Google Patents

Forskydningsresistent mikroelektrode, mikroelektrodebundt og mikroelektrodegruppe Download PDF

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Publication number
DK2612691T3
DK2612691T3 DK13159215.6T DK13159215T DK2612691T3 DK 2612691 T3 DK2612691 T3 DK 2612691T3 DK 13159215 T DK13159215 T DK 13159215T DK 2612691 T3 DK2612691 T3 DK 2612691T3
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DK
Denmark
Prior art keywords
electrode
microelectrode
electronic amplifier
tissue
microprocessor means
Prior art date
Application number
DK13159215.6T
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English (en)
Inventor
Jens Schouenborg
Gustav Lind
Christopher Hirst
Lars-Åke Clementz
Original Assignee
Neuronano Ab
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Publication of DK2612691T3 publication Critical patent/DK2612691T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526Head electrodes
    • A61N1/0529Electrodes for brain stimulation
    • A61N1/0536Preventing neurodegenerative response or inflammatory reaction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551Spinal or peripheral nerve electrodes
    • A61N1/0558Anchoring or fixation means therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128Control systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/37205Microstimulators, e.g. implantable through a cannula
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/37211Means for communicating with stimulators
    • A61N1/37252Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Electrotherapy Devices (AREA)

Claims (19)

1. Medicinsk mikroelektrode til implantation i blødt væv hos en person eller et dyr, og som er resistent overfor forskydning i vævet som følge af inerti, hvor elektroden har en forende, en bagende og en massefylde ved 20° C på fra 0,80 g/cm3 til 1,15g/cm3, især fra 0,90 g/cm3 til 1,07 g/cm3, i særdeleshed fra 0,95 g/cm3 til 1,03 g/cm3, omfattende en elektrisk ledende trådledning indeholdende eller bestående af et metal og/eller en elektrisk ledende polymer, hvor ledningen har en overflade og et opdriftselement med en massefylde på mindre end 1,0 g/cm3 fastgjort til overfladen; hvor overfladen er elektrisk isoleret; hvor opdriftselementet omfatter en polymer indeholdende lukkede porer.
2. Elektrode ifølge krav 1, hvori massefylden af polymeren ved 20° C er mindre end 0,8 g/cm3, fortrinsvis mindre end 0,6 g/cm3.
3. Elektrode ifølge krav 1, hvori polymeren er bøjelig, især elastisk bøjelig.
4. Elektrode ifølge krav 1 helt eller delvis indlejret i en matrix, der kan opløses eller nedbrydes i en legemsvæske.
5. Elektrode ifølge krav 1 omfattende et elektronisk forstærkerorgan og/eller et mikroprocessororgan, med det forbehold, at kombinationen af elektrode og elektronisk forstærker-/mikroprocessororgan har en massefylde ved 20° C på fra 0,80 g/cm3 til 1,15 g/cm3, især fra 0,90 g/cm3 til 1,07 g/cm3, i særdeleshed fra 0,95 g/cm3 til 1,03 g/cm3.
6. Elektrode ifølge krav 5, hvori massefylden af kombinationen af elektrode og elektronisk forstærker-/mikroprocessororgan er 0,99 ± 0,02 g/cm3.
7. Elektrode ifølge krav 5, hvori det elektroniske forstærker-/mikroprocessororgan er anbragt ved eller nær bagenden.
8. Elektrode ifølge krav 1 fastgjort ved eller nær sin bagende til en ultratynd isoleret tråd til elektrisk kommunikation med et elektronisk forstærker-/mikroprocessororgan anbragt i afstand derfra.
9. Elektrode ifølge krav 8, hvori den ultratynde isolerede tråd er integreret med elektrodetråden.
10. Elektrode ifølge krav 5, hvori det elektroniske forstærker-/mikroprocessororgan kan anbringes i blødt væv hos personen eller dyret.
11. Elektrode ifølge krav 5, hvori det elektroniske forstærker-/mikroprocessororgan omfatter en kilde med elektrisk energi.
12. Elektrode ifølge krav 5, hvori det elektroniske forstærker-/mikroprocessororgan omfatter et organ til udsendelse og/eller modtagelse af stråling til/fra en kontrolenhed anbragt eksternt i forhold til patienten eller dyret.
13. Elektrode ifølge krav 1 omfattende forankringsorganer anbragt ved eller nær dens forende.
14. Elektrodebundt indeholdende to eller flere elektroder ifølge ethvert af kravene 1-13.
15. Elektrodebundt ifølge krav 14 delvis eller helt indesluttet i et materiale, der kan opløses eller nedbrydes i en legemsvæske.
16. Elektrodegruppe indeholdende to eller flere elektroder ifølge ethvert af kravene 1-13.
17. Elektrodegruppe indeholdende to eller flere elektrodebundter ifølge krav 14 eller 15.
18. Elektrodegruppe ifølge krav 16 delvis eller helt indesluttet i et materiale, der kan opløses eller nedbrydes i en legemsvæske.
19. Elektrode ifølge ethvert af kravene 1 -13, elektrodebundt ifølge ethvert af kravene 14-15 eller elektrodegruppe ifølge ethvert af kravene 16-18 indeholdende et forseglet porøst materiale.
DK13159215.6T 2010-08-25 2011-08-25 Forskydningsresistent mikroelektrode, mikroelektrodebundt og mikroelektrodegruppe DK2612691T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE1000862 2010-08-25
EP11748413.9A EP2608839B1 (en) 2010-08-25 2011-08-25 Displacement resistant microelectrode, microelectrode bundle and microelectrode array

Publications (1)

Publication Number Publication Date
DK2612691T3 true DK2612691T3 (da) 2015-02-16

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DK11748413.9T DK2608839T3 (da) 2010-08-25 2011-08-25 Forskydningsresistent mikroelektrode, mikroelektrodebundt og mikroelektrodegruppe
DK13159215.6T DK2612691T3 (da) 2010-08-25 2011-08-25 Forskydningsresistent mikroelektrode, mikroelektrodebundt og mikroelektrodegruppe

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Country Status (16)

Country Link
US (1) US8751014B2 (da)
EP (2) EP2608839B1 (da)
JP (1) JP5819964B2 (da)
KR (1) KR101841055B1 (da)
CN (1) CN103153392B (da)
AU (1) AU2011294993B2 (da)
BR (1) BR112013004428B1 (da)
CA (1) CA2812004C (da)
DK (2) DK2608839T3 (da)
EA (1) EA022775B1 (da)
ES (2) ES2530094T3 (da)
HK (1) HK1184090A1 (da)
MY (1) MY164554A (da)
PL (2) PL2612691T3 (da)
SG (1) SG187918A1 (da)
WO (1) WO2012025596A2 (da)

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WO2015017543A2 (en) * 2013-07-30 2015-02-05 Massachusetts Institute Of Technology Systems and methods for delivering chemical and electrical stimulation across one or more neural circuits
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CN106029161B (zh) * 2013-12-20 2019-09-03 神经毫微股份公司 包括电极和光源的医疗设备
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WO2017010930A1 (en) 2015-07-10 2017-01-19 Neuronano Ab Method and system for improving stimulation of excitable tissue
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CN106646048B (zh) * 2016-12-23 2019-11-12 深圳市中科先见医疗科技有限公司 一种微电极阵列的制备方法
EP3630270A4 (en) * 2017-05-29 2021-03-03 Neuronano AB METHOD OF MICROELECTRODE IDENTIFICATION
US11969589B2 (en) 2017-11-09 2024-04-30 Neuronano Ab Positional stabilization of tissue-implanted medical devices
CN113194859A (zh) 2018-12-13 2021-07-30 纽韦弗医疗设备公司 能量递送装置和相关系统
EP3906089B1 (en) * 2019-01-04 2023-09-13 Neuronano AB Probe for implantation into nervous tissue comprising a microelectrode or a set of microelectrodes
CN113613711B (zh) * 2019-02-04 2024-09-17 新泽西州立罗格斯大学 使用微电极进行组织电转移的装置
CN109908467B (zh) * 2019-04-25 2024-04-30 北京品驰医疗设备有限公司 神经电刺激电极组件及其制备方法
CN112869747B (zh) * 2019-11-29 2022-11-25 清华大学 微电极及其制作和使用方法、塞类装置和微电极系统

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Publication number Publication date
CN103153392B (zh) 2016-03-09
CA2812004A1 (en) 2012-03-01
JP2013537466A (ja) 2013-10-03
JP5819964B2 (ja) 2015-11-24
EA022775B1 (ru) 2016-02-29
US8751014B2 (en) 2014-06-10
EA201390219A1 (ru) 2013-08-30
KR20130136454A (ko) 2013-12-12
EP2608839B1 (en) 2015-01-14
HK1184090A1 (zh) 2014-01-17
KR101841055B1 (ko) 2018-03-22
ES2534421T3 (es) 2015-04-22
BR112013004428B1 (pt) 2021-03-02
BR112013004428A2 (pt) 2016-05-31
PL2612691T3 (pl) 2015-04-30
AU2011294993A1 (en) 2013-02-14
DK2608839T3 (da) 2015-04-20
EP2612691A1 (en) 2013-07-10
PL2608839T3 (pl) 2015-06-30
WO2012025596A3 (en) 2012-04-26
US20130190851A1 (en) 2013-07-25
EP2608839A2 (en) 2013-07-03
CA2812004C (en) 2017-04-11
EP2612691B1 (en) 2014-11-12
ES2530094T3 (es) 2015-02-26
SG187918A1 (en) 2013-04-30
MY164554A (en) 2018-01-15
AU2011294993B2 (en) 2014-05-01
WO2012025596A2 (en) 2012-03-01
CN103153392A (zh) 2013-06-12

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