DK2611482T3 - Lægemiddelafgivelsesindretning - Google Patents

Lægemiddelafgivelsesindretning Download PDF

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Publication number
DK2611482T3
DK2611482T3 DK11822212.4T DK11822212T DK2611482T3 DK 2611482 T3 DK2611482 T3 DK 2611482T3 DK 11822212 T DK11822212 T DK 11822212T DK 2611482 T3 DK2611482 T3 DK 2611482T3
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DK
Denmark
Prior art keywords
delivery device
drug delivery
holding
distal
housing part
Prior art date
Application number
DK11822212.4T
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English (en)
Inventor
Anders Holmqvist
Sebastian Karlsson
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Shl Group Ab
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Publication of DK2611482T3 publication Critical patent/DK2611482T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31571—Means preventing accidental administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3146—Priming, e.g. purging, reducing backlash or clearance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock

Claims (12)

1
1. Lægemiddelafgivelsesindretning omfattende: - et hus, der omfatter en proksimal husdel (12) og en distal husdel (10), som er således anbragt og monteret, at de kan bevæges i forhold til hinanden, 5 - en drivkraftmekanisme anbragt i den distale husdel og omfattende mod koblingsmidler, - en beholder (22) fyldt med lægemiddel og anbragt i den proksimale husdel, - et holdeorgan (50), der er funktionelt koblet til drivkraftmekanismen til at ίο holde drivkraftmekanismen i en spændt tilstand, og hvor holdeorganet omfatter koblingsmidler og indgrebsmidler, - et aktiveringsorgan (56), der er indrettet til at samvirke med holdeorganet til frigørelse af drivkraftmekanismen fra sin spændte tilstand, og hvor aktiveringsorganet omfatter mod-indgrebsmidler, 15 kendetegnet ved, at holdeorganet (50) er indrettet til at blive bevæget af den proksimale husdel (12), når husdelene bevæges mod hinanden fra en adskilt position, hvori holdeorganet er adskilt fra aktiveringsorganet, til en indgrebsposition, hvori holdeorganet er i indgreb med aktiveringsorganet, således at holdeorganets (50) indgrebsmidler og aktiveringsorganets (56) mod-20 indgrebsmidler samvirker til at bringe aktiveringsorganets (56) koblingsmidler i indgreb med drivkraftmekanismens mod-koblingsmidler.
2. Lægemiddelafgivelsesindretning ifølge krav 1, hvor den proksimale husdel (12) omfatter et samvirkningsmiddel (60), og holdeorganet (50) omfatter et mod-samvirkningsmiddel (62), som samvirker om at bevæge holdeorganet fra den 25 adskilte position til indgrebspositionen.
3. Lægemiddelafgivelsesindretning ifølge krav 1 eller 2, hvor aktiveringsorganet (56) omfatter en berøringsdel, der udrager fra den distale husdel (10), og hvor aktiveringsorganet er anbragt elastisk på den distale husdel, således at aktiveringsorganet (56), når holdeorganet (50) er i den adskilte position, 30 kan bevæges i forhold til den distale husdel uden at påvirke drivkraftmekanismen.
4. Lægemiddelafgivelsesindretning ifølge ethvert af kravene 1 -3, hvor drivkraftmekanismen omfatter en stempelstang (32), en drivkraftfjeder (34) og et drivorgan (40).
5. Lægemiddelafgivelsesindretning ifølge krav 4, hvor drivorganet (40) omfatter løsbare midler (44), og stempelstangen (32) omfatter mod-løsbare midler (42), som samvirker til at bringe stempelstangen i løsbart indgreb med drivorganet.
6. Lægemiddelafgivelsesindretning ifølge krav 5, hvor drivorganets (40) løsbare midler (44) er radialt bøjelige arme udstyret med indadrettede lister (46), og stempelstangens (32) mod-løsbare midler (42) er en rille på dens ydre periferioverflade, hvor de indadrettede lister (46) passer ind i rillen, og hvor holdeorganet (50) er indrettet til fuldstændig omslutning af de radialt bøjelige arme, når holdeorganet er i den adskilte position.
7. Lægemiddelafgivelsesindretning ifølge ethvert af kravene 2-6, hvor den proksimale husdels (12) samvirkningsmiddel (60) er en distal, ringformet endeflade af den proksimale husdel (12), og holdeorganets (50) mod-samvirkningsmiddel (62) er en ringformet liste på den ydre periferi af holdeorganet.
8. Lægemiddelafgivelsesindretning ifølge ethvert af kravene 1 -7, hvor holdeorganets (50) indgrebsmidler er distalt rettede tunger, og aktiveringsorganets (56) mod-indgrebsmidler er proksimalt rettede, bøjelige tunger.
9. Lægemiddelafgivelsesindretning ifølge ethvert af kravene 1 -8, hvor aktiveringsorganets (56) koblingsmidler er radialt indadrettede fremspring på aktiveringsorganets proksimalt rettede, bøjelige tunger, og drivkraftmekanismens mod-koblingsmidler er fordybninger på den distale yderflade af drivorganet (40), således at fordybningerne er konfigureret til at modtage de radialt indadrettede fremspring.
10. Lægemiddelafgivelsesindretning ifølge ethvert af kravene 5-6, hvor holdeorganet bevæges af den proksimale husdel (12) fra den adskilte position til indgrebspositionen, hvori holdeorganet er delvis omgivet af de radialt bøjelige arme (44) og er i indgreb med aktiveringsorganet.
11. Lægemiddelafgivelsesindretning ifølge ethvert af kravene 1 -10, hvor beholderen (22) er en flerkammer-lægemiddelbeholder, og hvorved flerkammeret kan blandes ved bevægelse af husdelene mod hinanden.
12. Lægemiddelafgivelsesindretning ifølge krav 11, hvor holdeorganets indgrebsposition svarer til en position af flerkammeret, i hvilken flerkammeret blandes.
DK11822212.4T 2010-08-31 2011-08-23 Lægemiddelafgivelsesindretning DK2611482T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37860310P 2010-08-31 2010-08-31
SE1050897 2010-08-31
US38029110P 2010-09-06 2010-09-06
SE1050913 2010-09-06
PCT/SE2011/051012 WO2012030277A1 (en) 2010-08-31 2011-08-23 Medicament delivery device

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DK2611482T3 true DK2611482T3 (da) 2018-11-05

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US (1) US8961455B2 (da)
EP (1) EP2611482B1 (da)
JP (1) JP5663091B2 (da)
KR (1) KR101543931B1 (da)
CN (1) CN103153365B (da)
DK (1) DK2611482T3 (da)
TW (1) TWI459985B (da)
WO (1) WO2012030277A1 (da)

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Publication number Publication date
CN103153365B (zh) 2015-12-09
CN103153365A (zh) 2013-06-12
KR20130066668A (ko) 2013-06-20
EP2611482A4 (en) 2014-01-29
KR101543931B1 (ko) 2015-08-11
US20140155820A1 (en) 2014-06-05
EP2611482B1 (en) 2018-08-08
JP2013536726A (ja) 2013-09-26
WO2012030277A1 (en) 2012-03-08
EP2611482A1 (en) 2013-07-10
TW201217025A (en) 2012-05-01
US8961455B2 (en) 2015-02-24
JP5663091B2 (ja) 2015-02-04
TWI459985B (zh) 2014-11-11

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