DK2544693T3 - Hidtil ukendt tilgang til vaccination gennem slimhinder mod herpes simplex-virus type-2 - Google Patents
Hidtil ukendt tilgang til vaccination gennem slimhinder mod herpes simplex-virus type-2 Download PDFInfo
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- DK2544693T3 DK2544693T3 DK11754011.2T DK11754011T DK2544693T3 DK 2544693 T3 DK2544693 T3 DK 2544693T3 DK 11754011 T DK11754011 T DK 11754011T DK 2544693 T3 DK2544693 T3 DK 2544693T3
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Claims (9)
1. Priming-præparat og boosting-præparat til anvendelse i en fremgangsmåde til fremkaldelse af en beskyttende immunreaktion mod HSV-2 hos et pattedyr, hvilken fremgangsmåde omfatter at indgive priming-præparatet og boosting-præparatet til pattedyret: (a) hvor priming-præparatet omfatter en vektor, der koder for et HSV-2-antigen under styring af en promoter, hvor antigenet er et fuldlængde-HSV-2 gD-glycoprotein, og hvor sekvensen, der koder for gD-glycoproteinet, er ko-don-optimeret til ekspression i pattedyrsceller; og (b) hvor boosting-præparatet omfatter et ekstracellulært domæne af gD-glycoproteinet indkapslet i liposomer, hvor, i fremgangsmåden, priming-præparatet indgives intramuskulært, og boosting-præparatet indgives mukosalt, hvorved den beskyttende immunreaktion fremkaldes hos pattedyret.
2. Priming-præparat og boosting-præparat til anvendelse ifølge krav 1, hvor gD-glycoprotein-sekvensen er kodon-optimeret til ekspression i humane celler.
3. Priming-præparat og boosting-præparat til anvendelse ifølge krav 1, hvor vektoren koder for en fuldlængde-gD-glycoprotein-sekvens omfattende sekvensen med SEQ ID NO: 1.
4. Priming-præparat og boosting-præparat til anvendelse ifølge krav 1, hvor det ekstracellulære domæne af gD-glycoproteinet omfatter en sekvens med SEQ ID NO: 2.
5. Priming-præparat og boosting-præparat til anvendelse ifølge krav 1, hvor liposomerne er anioniske liposomer.
6. Priming-præparat og boosting-præparat til anvendelse ifølge krav 1, hvor boosting-præparatet indgives intranasalt.
7. Priming-præparat og boosting-præparat til anvendelse ifølge krav 1, hvor et eller flere symptomer på HSV-2-infektion bedres hos pattedyret efter indgivelse af boosting-præparatet.
8. Priming-præparat og boosting-præparat til anvendelse ifølge krav 7, hvor et eller flere symptomer på HSV-2-infektion er viral shedding.
9. Priming-præparat og boosting-præparat til anvendelse ifølge krav 6, hvor vaginal virusbelastning hos pattedyret reduceres.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31212210P | 2010-03-09 | 2010-03-09 | |
| PCT/US2011/027751 WO2011112717A1 (en) | 2010-03-09 | 2011-03-09 | A novel mucosal vaccination approach for herpes simplex virus type-2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2544693T3 true DK2544693T3 (da) | 2017-12-04 |
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| DK11754011.2T DK2544693T3 (da) | 2010-03-09 | 2011-03-09 | Hidtil ukendt tilgang til vaccination gennem slimhinder mod herpes simplex-virus type-2 |
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| US (4) | US20130195961A1 (da) |
| EP (1) | EP2544693B1 (da) |
| CA (1) | CA2792679C (da) |
| DK (1) | DK2544693T3 (da) |
| ES (1) | ES2651005T3 (da) |
| WO (1) | WO2011112717A1 (da) |
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| CA2552004C (en) * | 2004-01-07 | 2013-03-05 | Biomedical Research Models, Inc. | Methods for tailoring the immune response to an antigen or immunogen |
| MY159500A (en) | 2009-05-22 | 2017-01-13 | Genocea Biosciences Inc | Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response |
| PT2591114T (pt) | 2010-07-06 | 2016-08-02 | Glaxosmithkline Biologicals Sa | Imunização de mamíferos de grande porte com doses baixas de arn |
| PT2590626E (pt) | 2010-07-06 | 2016-01-26 | Glaxosmithkline Biolog Sa | Lipossomas com lípidos que têm um valor de pka vantajoso para administração de arn |
| ES2646669T3 (es) | 2010-07-06 | 2017-12-14 | Glaxosmithkline Biologicals Sa | Procedimientos de aumento de una respuesta inmunitaria mediante el suministro de ARN |
| EP4066857B1 (en) | 2010-08-31 | 2022-12-21 | GlaxoSmithKline Biologicals SA | Pegylated liposomes for delivery of immunogen-encoding rna |
| KR102162111B1 (ko) | 2010-10-11 | 2020-10-07 | 노파르티스 아게 | 항원 전달 플랫폼 |
| WO2012074881A2 (en) | 2010-11-24 | 2012-06-07 | Genocea Biosciences, Inc. | Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response |
| EP2729165B1 (en) | 2011-07-06 | 2017-11-08 | GlaxoSmithKline Biologicals SA | Immunogenic combination compositions and uses thereof |
| WO2013078299A1 (en) * | 2011-11-23 | 2013-05-30 | Genocea Biosciences, Inc. | Nucleic acid vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response |
| EP2941269B1 (en) * | 2013-01-07 | 2020-12-09 | Mucosal Vaccine Technologies LLC | Therapeutic vaccines for treating herpes simplex virus type 2 infections |
| GB201301119D0 (en) * | 2013-01-22 | 2013-03-06 | Vaxxit Srl | Viral vaccines |
| WO2018064232A1 (en) | 2016-09-28 | 2018-04-05 | Genocea Biosciences, Inc. | Methods and compositions for treating herpes |
| WO2019152821A1 (en) * | 2018-02-05 | 2019-08-08 | The Brigham And Women's Hospital, Inc. | Recombinant herpes simplex virus-2 expressing glycoprotein b and d antigens |
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| US4920016A (en) | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US4999403A (en) | 1988-10-28 | 1991-03-12 | Exxon Chemical Patents Inc. | Graft polymers of functionalized ethylene-alpha-olefin copolymer with polypropylene, methods of preparation, and use in polypropylene compositions |
| RU2121481C1 (ru) | 1988-12-16 | 1998-11-10 | Де Стат Дер Недерланден Вертегенвордигд Дор де Министр Ван Велзейн, Волксгезондхейд эн Кюлтюр | Модифицированный пневмолизин, рекомбинантная плазмида, способ получения модифицированного пневмолизина, вакцина |
| US5543152A (en) | 1994-06-20 | 1996-08-06 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US5858397A (en) | 1995-10-11 | 1999-01-12 | University Of British Columbia | Liposomal formulations of mitoxantrone |
| US6764686B2 (en) | 1997-07-21 | 2004-07-20 | Baxter International Inc. | Modified immunogenic pneumolysin compositions as vaccines |
| US7459524B1 (en) | 1997-10-02 | 2008-12-02 | Emergent Product Development Gaithersburg Inc. | Chlamydia protein, sequence and uses thereof |
| WO1999028475A2 (en) | 1997-11-28 | 1999-06-10 | Genset | Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection |
| HUP0101047A3 (en) * | 1998-03-09 | 2004-10-28 | Smithkline Beecham Biolog | Combined vaccine compositions |
| CA2326598C (en) | 1998-04-07 | 2014-06-10 | Corixa Corporation | Fusion proteins of mycobacterium tuberculosis antigens and their uses |
| US7569218B2 (en) * | 2000-07-27 | 2009-08-04 | The Trustees Of The University Of Pennsylvania | Compositions for and methods of using herpes simplex virus glycoprotein D to suppress immune responses |
| CA2552004C (en) * | 2004-01-07 | 2013-03-05 | Biomedical Research Models, Inc. | Methods for tailoring the immune response to an antigen or immunogen |
| US8865185B2 (en) * | 2006-09-08 | 2014-10-21 | The Trustees Of The University Of Pennsylvania | Methods of use for HSV-1 and HSV-2 vaccines |
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2011
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- 2011-03-09 US US13/583,845 patent/US20130195961A1/en not_active Abandoned
- 2011-03-09 US US13/044,379 patent/US20120027841A1/en not_active Abandoned
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2016
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2017
- 2017-08-11 US US15/674,929 patent/US20180193448A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20180193448A1 (en) | 2018-07-12 |
| US20170258894A1 (en) | 2017-09-14 |
| ES2651005T3 (es) | 2018-01-23 |
| US20120027841A1 (en) | 2012-02-02 |
| CA2792679A1 (en) | 2011-09-15 |
| US20130195961A1 (en) | 2013-08-01 |
| EP2544693A4 (en) | 2013-08-21 |
| EP2544693B1 (en) | 2017-09-13 |
| CA2792679C (en) | 2019-11-12 |
| EP2544693A1 (en) | 2013-01-16 |
| WO2011112717A1 (en) | 2011-09-15 |
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