DK2523938T3 - Amidoacridinderivater brugbare såsom selektive inhibitorer af ubiquitinspecifik protease 7 - Google Patents
Amidoacridinderivater brugbare såsom selektive inhibitorer af ubiquitinspecifik protease 7Info
- Publication number
- DK2523938T3 DK2523938T3 DK11701220.3T DK11701220T DK2523938T3 DK 2523938 T3 DK2523938 T3 DK 2523938T3 DK 11701220 T DK11701220 T DK 11701220T DK 2523938 T3 DK2523938 T3 DK 2523938T3
- Authority
- DK
- Denmark
- Prior art keywords
- amidoacridine
- ubiquitin
- selective inhibitors
- specific protease
- derivatives useful
- Prior art date
Links
- 229940124639 Selective inhibitor Drugs 0.000 title 1
- 102000018390 Ubiquitin-Specific Proteases Human genes 0.000 title 1
- 108010066496 Ubiquitin-Specific Proteases Proteins 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Psychology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29539910P | 2010-01-15 | 2010-01-15 | |
EP10172844A EP2357176A1 (en) | 2010-01-15 | 2010-08-13 | Amidoacridine derivatives useful as selective inhibitors of ubiquitin specific protease 7 |
US12/855,983 US20110177105A1 (en) | 2010-01-15 | 2010-08-13 | Novel Selective Inhibitors of Ubiquitin Specific Protease 7, the Pharmaceutical Compositions Thereof and Their Therapeutic Applications |
PCT/EP2011/050523 WO2011086178A1 (en) | 2010-01-15 | 2011-01-17 | Amidoacridine derivatives useful as selective inhibitors of ubiquitin specific protease 7 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2523938T3 true DK2523938T3 (da) | 2014-10-27 |
Family
ID=42829956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK11701220.3T DK2523938T3 (da) | 2010-01-15 | 2011-01-17 | Amidoacridinderivater brugbare såsom selektive inhibitorer af ubiquitinspecifik protease 7 |
Country Status (12)
Country | Link |
---|---|
US (3) | US20110177105A1 (da) |
EP (2) | EP2357176A1 (da) |
JP (1) | JP6005524B2 (da) |
KR (1) | KR101800164B1 (da) |
CN (1) | CN102781919B (da) |
CA (1) | CA2786957C (da) |
DK (1) | DK2523938T3 (da) |
ES (1) | ES2523383T3 (da) |
PL (1) | PL2523938T3 (da) |
PT (1) | PT2523938E (da) |
SI (1) | SI2523938T1 (da) |
WO (1) | WO2011086178A1 (da) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2565186A1 (en) | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
JP6678455B2 (ja) * | 2012-12-21 | 2020-04-08 | エピザイム,インコーポレイティド | Prmt5阻害剤およびその使用 |
EP2801569A1 (en) | 2013-05-09 | 2014-11-12 | Ikerchem, S.L. | Histone deacetylase inhibitors based on derivatives of tricyclic polyhydroacridine and analogs possessing fused saturated five- and seven-membered rings |
CN105251020B (zh) * | 2015-09-29 | 2018-10-09 | 武汉大学 | 泛素特异性蛋白酶4(usp4)在治疗心肌肥厚中的功能及应用 |
WO2017061957A1 (en) | 2015-10-09 | 2017-04-13 | Agency For Science, Technology And Research | Compounds for treatment of cancer and epigenetics |
US11497729B2 (en) | 2016-07-08 | 2022-11-15 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
GB201617758D0 (en) | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
MX2020003242A (es) | 2017-09-22 | 2020-09-18 | Jubilant Epipad LLC | Compuestos heterociclicos como inhibidores de pad. |
JP7307723B2 (ja) | 2017-10-18 | 2023-07-12 | ジュビラント エピパッド エルエルシー | Pad阻害剤としてのイミダゾ-ピリジン化合物 |
MX2020004699A (es) | 2017-11-06 | 2022-10-26 | Jubilant Prodel LLC | Derivados de pirimidina como inhibidores de la activacion de pd1/pd-l1. |
CA3083374A1 (en) | 2017-11-24 | 2019-05-31 | Jubilant Episcribe Llc | Heterocyclic compounds as prmt5 inhibitors |
CN112105610B (zh) | 2018-03-13 | 2024-01-26 | 朱比连特普罗德尔有限责任公司 | 作为pd1/pd-l1相互作用/活化的抑制剂的双环化合物 |
GB202001980D0 (en) | 2020-02-13 | 2020-04-01 | Almac Discovery Ltd | Therapeutic mentods |
GB202200753D0 (en) | 2022-01-21 | 2022-03-09 | Almac Discovery Ltd | Pharmaceutical compounds |
CN115557890B (zh) * | 2022-09-01 | 2024-06-25 | 宁波大学 | 一种多取代吖啶酮烷基衍生物及其制备方法和用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1886481A (en) * | 1927-11-07 | 1932-11-08 | Soc Of Chemical Ind | Unilaterally acylated diamines and process of making same |
WO2006072048A2 (en) | 2004-12-30 | 2006-07-06 | The Trustees Of Princeton University | Compositions and methods for identifying modulators of hausp |
DE602005010421D1 (de) * | 2005-08-05 | 2008-11-27 | Hybrigenics Sa | Neue Cysteine Protease Hemmers und ihre therapeutische Anwendungen |
US8642660B2 (en) * | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
-
2010
- 2010-08-13 US US12/855,983 patent/US20110177105A1/en not_active Abandoned
- 2010-08-13 EP EP10172844A patent/EP2357176A1/en not_active Withdrawn
-
2011
- 2011-01-17 DK DK11701220.3T patent/DK2523938T3/da active
- 2011-01-17 JP JP2012548453A patent/JP6005524B2/ja not_active Expired - Fee Related
- 2011-01-17 PT PT117012203T patent/PT2523938E/pt unknown
- 2011-01-17 CA CA2786957A patent/CA2786957C/en not_active Expired - Fee Related
- 2011-01-17 SI SI201130305T patent/SI2523938T1/sl unknown
- 2011-01-17 EP EP11701220.3A patent/EP2523938B1/en not_active Not-in-force
- 2011-01-17 WO PCT/EP2011/050523 patent/WO2011086178A1/en active Application Filing
- 2011-01-17 US US13/521,978 patent/US20130023521A1/en not_active Abandoned
- 2011-01-17 KR KR1020127021238A patent/KR101800164B1/ko active IP Right Grant
- 2011-01-17 PL PL11701220T patent/PL2523938T3/pl unknown
- 2011-01-17 ES ES11701220.3T patent/ES2523383T3/es active Active
- 2011-01-17 CN CN201180010555.9A patent/CN102781919B/zh not_active Expired - Fee Related
-
2014
- 2014-09-17 US US14/488,601 patent/US9328093B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN102781919A (zh) | 2012-11-14 |
KR101800164B1 (ko) | 2017-11-22 |
PT2523938E (pt) | 2014-11-25 |
PL2523938T3 (pl) | 2015-02-27 |
CN102781919B (zh) | 2016-01-20 |
JP2013517257A (ja) | 2013-05-16 |
CA2786957A1 (en) | 2011-07-21 |
EP2523938A1 (en) | 2012-11-21 |
US20150072973A1 (en) | 2015-03-12 |
EP2523938B1 (en) | 2014-09-03 |
US20110177105A1 (en) | 2011-07-21 |
KR20120125629A (ko) | 2012-11-16 |
WO2011086178A1 (en) | 2011-07-21 |
JP6005524B2 (ja) | 2016-10-12 |
EP2357176A1 (en) | 2011-08-17 |
ES2523383T3 (es) | 2014-11-25 |
CA2786957C (en) | 2018-02-27 |
US9328093B2 (en) | 2016-05-03 |
SI2523938T1 (sl) | 2014-12-31 |
US20130023521A1 (en) | 2013-01-24 |
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