DK2501754T3 - Hidtil ukendt formulering af blandinger af fysiologisk chitosan-uorganisk salt-opløsning/blod til vævsreparation - Google Patents
Hidtil ukendt formulering af blandinger af fysiologisk chitosan-uorganisk salt-opløsning/blod til vævsreparation Download PDFInfo
- Publication number
- DK2501754T3 DK2501754T3 DK10831000.4T DK10831000T DK2501754T3 DK 2501754 T3 DK2501754 T3 DK 2501754T3 DK 10831000 T DK10831000 T DK 10831000T DK 2501754 T3 DK2501754 T3 DK 2501754T3
- Authority
- DK
- Denmark
- Prior art keywords
- chitosan
- blood
- hcl
- tissue
- clots
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3616—Blood, e.g. platelet-rich plasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/10—Heparin; Derivatives thereof
Claims (7)
1. Blod/chitosan-HCI-NaCI-sammensætning, omfattende: a) fuldblod; og b) en chitosanopløsning omfattende: chitosan med en gennemsnitlig molekylvægt på Mn < 232 kDa, HCI, og NaCI i en koncentration på 160 mM; hvor blod/chitosan-HCI-NaCI-sammensætningen har en pH-værdi på mellem 6,0 og 7,8; og hvor blod/chitosan-HCI-NaCI-sammensætningen koagulerer hurtigere end en blod/chitosan-HCI-3-glycerolphosphat-sammensætning.
2. Blod/chitosan-HCI-NaCI-sammensætning ifølge krav 1, hvor polymersammensætningen har en pH-værdi på mellem 6,2 og 6,7, og mere foretrukket en pH-værdi på 6,6.
3. Blod/chitosan-HCI-NaCI-sammensætning ifølge krav 1 eller 2, hvordeacety-leringsgraden (DDA) af chitosan er mellem 20 % til 100 %, og mere foretrukket mellem 76 % og 98 %.
4. Blod/chitosan-HCI-NaCI-sammensætning ifølge et hvilket som helst af kravene 1 til 3, hvor forholdet fuldblod:chitosan er 3:1 v/v.
5. Blod/chitosan-HCI-NaCI-sammensætning ifølge krav 1, hvor HCI er i en koncentration på 38 mM.
6. Blod/chitosan-HCI-NaCI-sammensætning ifølge et hvilket som helst af kravene 1 til 5, til anvendelse til reparation af væv hos et individ, hvor polymersammensætningen hæfter til vævet og fremmer celleproliferation.
7. Blod/chitosan-HCI-NaCI-sammensætning til anvendelse ifølge krav 6, hvor vævet er udvalgt fra gruppen bestående af brusk, menisk, ledbånd, sene, knogle, hud, hornhinde, periodontale væv, maxillofaciale væv, temporomandi-bular-væv, abscesser, resecerede tumorer og sår.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26278609P | 2009-11-19 | 2009-11-19 | |
PCT/CA2010/001842 WO2011060544A1 (en) | 2009-11-19 | 2010-11-18 | Novel formulation of physiological chitosan-inorganic salt solution/blood mixtures for tissue repair |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2501754T3 true DK2501754T3 (da) | 2018-09-03 |
Family
ID=44059158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10831000.4T DK2501754T3 (da) | 2009-11-19 | 2010-11-18 | Hidtil ukendt formulering af blandinger af fysiologisk chitosan-uorganisk salt-opløsning/blod til vævsreparation |
Country Status (6)
Country | Link |
---|---|
US (2) | US20120321721A1 (da) |
EP (1) | EP2501754B1 (da) |
CA (1) | CA2814783A1 (da) |
DK (1) | DK2501754T3 (da) |
ES (1) | ES2688977T3 (da) |
WO (1) | WO2011060544A1 (da) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2918452T3 (es) | 2007-02-19 | 2022-07-15 | Marine Polymer Tech Inc | Composiciones hemostáticas y regímenes terapéuticos |
CN103239762B (zh) * | 2013-05-23 | 2014-09-17 | 中国海洋大学 | 一种甲壳素膜及其在眼科治疗中的应用 |
US11844874B2 (en) | 2014-02-20 | 2023-12-19 | Ortho Regenerative Technologies Inc. | Lyophilized polymer scaffold compositions, processes for preparation and use in anabolic wound repair |
FR3038838B1 (fr) | 2015-07-13 | 2017-08-18 | Synolyne Pharma | Chitosane pour melange avec un fluide coagulable |
CN109481726A (zh) * | 2018-11-26 | 2019-03-19 | 广州新诚生物科技有限公司 | 一种可生物降解的止血骨蜡及其制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3623414B2 (ja) * | 1999-11-05 | 2005-02-23 | ニッピコラーゲン工業株式会社 | ソーセージ用ケーシングおよびその製造方法 |
US6716970B2 (en) * | 2000-04-21 | 2004-04-06 | Adjuvant Pharmaceuticals, Llc | Water soluble, randomly substituted partial N-partial O-acetylated chitosan, preserving compositions containing chitosan, and processes for making thereof |
JP5089006B2 (ja) * | 2000-06-29 | 2012-12-05 | ピラマル ヘルスケア (カナダ) リミテッド | 軟骨および他の組織の修復および再生のための組成物および方法 |
US20060159663A1 (en) | 2004-07-30 | 2006-07-20 | Lu Helen H | Growth factor encapsulation system for enhancing bone formation |
US20060251628A1 (en) * | 2005-05-06 | 2006-11-09 | Mohamed Attawia | Defatted, dewatered bone marrow |
-
2010
- 2010-11-18 DK DK10831000.4T patent/DK2501754T3/da active
- 2010-11-18 EP EP10831000.4A patent/EP2501754B1/en active Active
- 2010-11-18 US US13/510,661 patent/US20120321721A1/en not_active Abandoned
- 2010-11-18 ES ES10831000.4T patent/ES2688977T3/es active Active
- 2010-11-18 WO PCT/CA2010/001842 patent/WO2011060544A1/en active Application Filing
- 2010-11-18 CA CA2814783A patent/CA2814783A1/en not_active Abandoned
-
2017
- 2017-06-22 US US15/629,795 patent/US20170333477A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20170333477A1 (en) | 2017-11-23 |
EP2501754A1 (en) | 2012-09-26 |
ES2688977T3 (es) | 2018-11-07 |
EP2501754B1 (en) | 2018-08-08 |
WO2011060544A1 (en) | 2011-05-26 |
US20120321721A1 (en) | 2012-12-20 |
EP2501754A4 (en) | 2013-08-07 |
CA2814783A1 (en) | 2011-05-26 |
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