DK249781A - Frmgangsmaade til fremstilling af pyrrolopyrrolcarboxylsyrer - Google Patents

Frmgangsmaade til fremstilling af pyrrolopyrrolcarboxylsyrer

Info

Publication number
DK249781A
DK249781A DK249781A DK249781A DK249781A DK 249781 A DK249781 A DK 249781A DK 249781 A DK249781 A DK 249781A DK 249781 A DK249781 A DK 249781A DK 249781 A DK249781 A DK 249781A
Authority
DK
Denmark
Prior art keywords
pyrrolopyrrolcarboxyl
preparing
acid
furyl
bromo
Prior art date
Application number
DK249781A
Other languages
Danish (da)
English (en)
Inventor
J M Muchowski
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of DK249781A publication Critical patent/DK249781A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK249781A 1980-06-09 1981-06-04 Frmgangsmaade til fremstilling af pyrrolopyrrolcarboxylsyrer DK249781A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/157,719 US4344943A (en) 1980-06-09 1980-06-09 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof

Publications (1)

Publication Number Publication Date
DK249781A true DK249781A (da) 1981-12-10

Family

ID=22564979

Family Applications (1)

Application Number Title Priority Date Filing Date
DK249781A DK249781A (da) 1980-06-09 1981-06-04 Frmgangsmaade til fremstilling af pyrrolopyrrolcarboxylsyrer

Country Status (19)

Country Link
US (1) US4344943A (de)
EP (1) EP0041711B1 (de)
JP (1) JPS5714591A (de)
KR (1) KR850000609B1 (de)
AT (1) ATE12771T1 (de)
AU (1) AU546012B2 (de)
CA (1) CA1178277A (de)
DE (1) DE3169956D1 (de)
DK (1) DK249781A (de)
ES (1) ES8203376A1 (de)
GR (1) GR74615B (de)
HU (1) HU185430B (de)
IE (1) IE51523B1 (de)
IL (1) IL63047A (de)
NZ (1) NZ197331A (de)
PT (1) PT73154B (de)
SU (1) SU1217260A3 (de)
YU (2) YU43235B (de)
ZA (1) ZA813829B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4457941A (en) * 1982-03-22 1984-07-03 Syntex (U.S.A.) Inc. Use of pyrrolo-pyrrole in treating microvascular diseases associated with diabetes
US4454151A (en) * 1982-03-22 1984-06-12 Syntex (U.S.A.) Inc. Use of pyrrolo pyrroles in treatment of ophthalmic diseases
US4612325A (en) * 1982-06-08 1986-09-16 Syntex (U.S.A) Inc. 5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1-carboxylic acids and use thereof as analgesics and anti-inflammatories
US4511724A (en) * 1982-06-10 1985-04-16 Merck & Co., Inc. 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
US4835288A (en) * 1987-01-14 1989-05-30 Syntex Inc. Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates
US4849526A (en) * 1987-01-14 1989-07-18 Syntex (U.S.A.) Inc. Process for preparing (±)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4874872A (en) * 1987-01-14 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
HU198927B (en) * 1987-01-14 1989-12-28 Richter Gedeon Vegyeszet Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
JP2649168B2 (ja) * 1988-02-25 1997-09-03 久光製薬株式会社 新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体
US5082950A (en) * 1990-10-12 1992-01-21 Syntex (U.S.A.) Inc. Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (II) and intermediates therefor
WO1995001767A1 (en) * 1993-07-08 1995-01-19 Cygnus Therapeutic Systems Monolithic matrix transdermal delivery system
US5621115A (en) * 1996-02-21 1997-04-15 Ohmeda Pharmaceutical Products Division Inc. Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids
US6191285B1 (en) 1997-07-03 2001-02-20 Abbott Laboratories Process for the preparation of ketorolac tromethamine
NZ520402A (en) * 2000-01-19 2006-04-28 Cadila Healthcare Ltd Novel compounds having hypolipedemic, hypocholesteremic activites, process for their preparation and pharmaceutical compositions containing them
WO2002062341A1 (en) * 2001-02-07 2002-08-15 University Of Florida Method and composition for the control of hair growth

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS539788A (en) * 1976-07-14 1978-01-28 Syntex Inc 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative
US4087539A (en) * 1976-07-14 1978-05-02 Syntex (U.S.A.) Inc. 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4089969A (en) * 1976-07-14 1978-05-16 Syntex (U.S.A.) Inc. 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4097579A (en) * 1977-03-31 1978-06-27 Syntex (U.S.A.) Inc. 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4140698A (en) * 1977-07-25 1979-02-20 Syntex (Usa) Inc. 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
US4232038A (en) * 1979-08-31 1980-11-04 Syntex (U.S.A.) Inc. 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids

Also Published As

Publication number Publication date
HU185430B (en) 1985-02-28
IE51523B1 (en) 1987-01-07
YU43235B (en) 1989-06-30
IE811269L (en) 1981-12-09
SU1217260A3 (ru) 1986-03-07
IL63047A (en) 1984-07-31
EP0041711B1 (de) 1985-04-17
IL63047A0 (en) 1981-09-13
PT73154B (en) 1982-07-16
YU137083A (en) 1983-12-31
KR830006289A (ko) 1983-09-20
DE3169956D1 (en) 1985-05-23
CA1178277A (en) 1984-11-20
PT73154A (en) 1981-07-01
ES502855A0 (es) 1982-04-01
ATE12771T1 (de) 1985-05-15
AU7143881A (en) 1981-12-17
JPS5714591A (en) 1982-01-25
YU142381A (en) 1983-12-31
EP0041711A1 (de) 1981-12-16
KR850000609B1 (ko) 1985-05-01
GR74615B (de) 1984-06-29
NZ197331A (en) 1985-05-31
US4344943A (en) 1982-08-17
ES8203376A1 (es) 1982-04-01
AU546012B2 (en) 1985-08-08
ZA813829B (en) 1983-01-26

Similar Documents

Publication Publication Date Title
DK249781A (da) Frmgangsmaade til fremstilling af pyrrolopyrrolcarboxylsyrer
IE780605L (en) 1, 2-DIHYDRO-3H-PYRROLO [1,2-a] PYRROLES
AU543580B2 (en) 4-hydroxy-3-quinoline carboxamides
DK18984D0 (da) 1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-carboxylsyrer
DE3578423D1 (de) Neue cephalosporine und verfahren zu ihrer herstellung.
JPS55118455A (en) Method of collecting optically active d-alpha-methyl-beta- mercapto propionic acid derivative
IE43929L (en) Thiophene derivative
ATE13061T1 (de) Neue 6alpha-methoxy-penicilline, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
JPS55122758A (en) Racemization of l-alpha-methyl-beta-acylthiopropionic acid
DK544980A (da) Fremgangsmaade til fremstilling af 2-phenylamino-imidazoliner
RU98123827A (ru) β,β-ДИЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 9-ДЕЗОКСО-9А-N-ЭТЕНИЛ-9А-АЗА-9А-ГОМОЭРИТРОМИЦИНА А
JPS5283732A (en) Haloazetidinone compounds
ATE11669T1 (de) Vasodilator, verfahren zur herstellung und arzneimittelzusammensetzungen.
DK22983A (da) Fremgangsmaade til fremstilling af penicillinderivater
ATE11141T1 (de) Neue cephalosporine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
SE8107683L (sv) Xantinderivat
JPS5251386A (en) Preparaton of -cephalosporanic acid derivatives
JPS537685A (en) Preparation of optical active lactams
JPS52122388A (en) Preparation of 7-amino-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid derivatives
ATA452779A (de) Verfahren zur herstellung von neuen 4,5,6,7- tetrahydro-2h-benzo(c)pyrrolderivaten und ihren pharmazeutisch annehmbaren saeureadditionssalzen
JPS5283625A (en) Cyclopentenedione derivative and preparation thereof
JPS5392730A (en) Novel o-(2, 6-dichloroanilino)phenylacetic acid ester derivatives
JPS5412382A (en) Optical resolution of dl-2-(p-methoxybenzyl)-1,3,4-trimethyl-1,2,5,6,- tetrahydropyridine

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment