PT73154B - Process for preparing 6-chloro-or 6-bromo-1,2-dihydro-3h-pyrrolo<1,2-a>-pyrrole-1-carboxylic acids and derivatives thereof - Google Patents
Process for preparing 6-chloro-or 6-bromo-1,2-dihydro-3h-pyrrolo<1,2-a>-pyrrole-1-carboxylic acids and derivatives thereofInfo
- Publication number
- PT73154B PT73154B PT73154A PT7315481A PT73154B PT 73154 B PT73154 B PT 73154B PT 73154 A PT73154 A PT 73154A PT 7315481 A PT7315481 A PT 7315481A PT 73154 B PT73154 B PT 73154B
- Authority
- PT
- Portugal
- Prior art keywords
- bromo
- chloro
- pyrrolo
- pyrrole
- dihydro
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- XWQXHYYQCCZBSH-UHFFFAOYSA-N 2-bromo-6,7-dihydro-5h-pyrrolizine-1-carboxylic acid Chemical class C1CCC2=C(C(=O)O)C(Br)=CN21 XWQXHYYQCCZBSH-UHFFFAOYSA-N 0.000 abstract 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 229940125716 antipyretic agent Drugs 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000050 smooth muscle relaxant Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/157,719 US4344943A (en) | 1980-06-09 | 1980-06-09 | 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT73154A PT73154A (en) | 1981-07-01 |
| PT73154B true PT73154B (en) | 1982-07-16 |
Family
ID=22564979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT73154A PT73154B (en) | 1980-06-09 | 1981-06-08 | Process for preparing 6-chloro-or 6-bromo-1,2-dihydro-3h-pyrrolo<1,2-a>-pyrrole-1-carboxylic acids and derivatives thereof |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4344943A (pt) |
| EP (1) | EP0041711B1 (pt) |
| JP (1) | JPS5714591A (pt) |
| KR (1) | KR850000609B1 (pt) |
| AT (1) | ATE12771T1 (pt) |
| AU (1) | AU546012B2 (pt) |
| CA (1) | CA1178277A (pt) |
| DE (1) | DE3169956D1 (pt) |
| DK (1) | DK249781A (pt) |
| ES (1) | ES8203376A1 (pt) |
| GR (1) | GR74615B (pt) |
| HU (1) | HU185430B (pt) |
| IE (1) | IE51523B1 (pt) |
| IL (1) | IL63047A (pt) |
| NZ (1) | NZ197331A (pt) |
| PT (1) | PT73154B (pt) |
| SU (1) | SU1217260A3 (pt) |
| YU (2) | YU43235B (pt) |
| ZA (1) | ZA813829B (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4457941A (en) * | 1982-03-22 | 1984-07-03 | Syntex (U.S.A.) Inc. | Use of pyrrolo-pyrrole in treating microvascular diseases associated with diabetes |
| US4454151A (en) * | 1982-03-22 | 1984-06-12 | Syntex (U.S.A.) Inc. | Use of pyrrolo pyrroles in treatment of ophthalmic diseases |
| US4612325A (en) * | 1982-06-08 | 1986-09-16 | Syntex (U.S.A) Inc. | 5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1-carboxylic acids and use thereof as analgesics and anti-inflammatories |
| US4511724A (en) * | 1982-06-10 | 1985-04-16 | Merck & Co., Inc. | 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents |
| HU198927B (en) * | 1987-01-14 | 1989-12-28 | Richter Gedeon Vegyeszet | Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same |
| US4874872A (en) * | 1987-01-14 | 1989-10-17 | Syntex (U.S.A.) Inc. | Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates |
| US4835288A (en) * | 1987-01-14 | 1989-05-30 | Syntex Inc. | Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates |
| US4849526A (en) * | 1987-01-14 | 1989-07-18 | Syntex (U.S.A.) Inc. | Process for preparing (±)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates |
| US4874871A (en) * | 1987-03-25 | 1989-10-17 | Syntex (U.S.A.) Inc. | Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds |
| JP2649168B2 (ja) * | 1988-02-25 | 1997-09-03 | 久光製薬株式会社 | 新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体 |
| US5082950A (en) * | 1990-10-12 | 1992-01-21 | Syntex (U.S.A.) Inc. | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (II) and intermediates therefor |
| EP0707465A4 (en) * | 1993-07-08 | 1997-04-16 | Cygnus Therapeutic Systems | Monolithic matrix transdermal delivery system |
| US5621115A (en) * | 1996-02-21 | 1997-04-15 | Ohmeda Pharmaceutical Products Division Inc. | Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids |
| US6191285B1 (en) | 1997-07-03 | 2001-02-20 | Abbott Laboratories | Process for the preparation of ketorolac tromethamine |
| CN1266129C (zh) * | 2000-01-19 | 2006-07-26 | 卡地拉健康护理有限公司 | 具有降血脂和降低血中胆固醇活性的新化合物、其制备方法和含有它们的药物组合物 |
| US20040131574A1 (en) * | 2001-02-07 | 2004-07-08 | Bergeron Raymond J | Method and composition for the control of hair growth |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS539788A (en) * | 1976-07-14 | 1978-01-28 | Syntex Inc | 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative |
| US4087539A (en) * | 1976-07-14 | 1978-05-02 | Syntex (U.S.A.) Inc. | 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
| US4089969A (en) * | 1976-07-14 | 1978-05-16 | Syntex (U.S.A.) Inc. | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
| US4097579A (en) * | 1977-03-31 | 1978-06-27 | Syntex (U.S.A.) Inc. | 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof |
| US4140698A (en) * | 1977-07-25 | 1979-02-20 | Syntex (Usa) Inc. | 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles |
| US4232038A (en) * | 1979-08-31 | 1980-11-04 | Syntex (U.S.A.) Inc. | 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids |
-
1980
- 1980-06-09 US US06/157,719 patent/US4344943A/en not_active Expired - Lifetime
-
1981
- 1981-04-02 JP JP4999181A patent/JPS5714591A/ja active Pending
- 1981-06-03 KR KR1019810001987A patent/KR850000609B1/ko not_active Expired
- 1981-06-04 DK DK249781A patent/DK249781A/da not_active Application Discontinuation
- 1981-06-05 YU YU1423/81A patent/YU43235B/xx unknown
- 1981-06-05 DE DE8181104368T patent/DE3169956D1/de not_active Expired
- 1981-06-05 AT AT81104368T patent/ATE12771T1/de not_active IP Right Cessation
- 1981-06-05 EP EP81104368A patent/EP0041711B1/en not_active Expired
- 1981-06-05 IL IL63047A patent/IL63047A/xx unknown
- 1981-06-08 HU HU811700A patent/HU185430B/hu not_active IP Right Cessation
- 1981-06-08 NZ NZ197331A patent/NZ197331A/en unknown
- 1981-06-08 GR GR65174A patent/GR74615B/el unknown
- 1981-06-08 ZA ZA00813829A patent/ZA813829B/xx unknown
- 1981-06-08 ES ES502855A patent/ES8203376A1/es not_active Expired
- 1981-06-08 PT PT73154A patent/PT73154B/pt unknown
- 1981-06-08 IE IE1269/81A patent/IE51523B1/en unknown
- 1981-06-08 CA CA000379266A patent/CA1178277A/en not_active Expired
- 1981-06-08 SU SU813300100A patent/SU1217260A3/ru active
- 1981-06-09 AU AU71438/81A patent/AU546012B2/en not_active Ceased
-
1983
- 1983-06-22 YU YU01370/83A patent/YU137083A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0041711A1 (en) | 1981-12-16 |
| ES502855A0 (es) | 1982-04-01 |
| YU43235B (en) | 1989-06-30 |
| EP0041711B1 (en) | 1985-04-17 |
| ZA813829B (en) | 1983-01-26 |
| ES8203376A1 (es) | 1982-04-01 |
| YU137083A (en) | 1983-12-31 |
| NZ197331A (en) | 1985-05-31 |
| KR830006289A (ko) | 1983-09-20 |
| JPS5714591A (en) | 1982-01-25 |
| IL63047A0 (en) | 1981-09-13 |
| KR850000609B1 (ko) | 1985-05-01 |
| AU546012B2 (en) | 1985-08-08 |
| HU185430B (en) | 1985-02-28 |
| SU1217260A3 (ru) | 1986-03-07 |
| YU142381A (en) | 1983-12-31 |
| DK249781A (da) | 1981-12-10 |
| US4344943A (en) | 1982-08-17 |
| IE51523B1 (en) | 1987-01-07 |
| CA1178277A (en) | 1984-11-20 |
| ATE12771T1 (de) | 1985-05-15 |
| AU7143881A (en) | 1981-12-17 |
| IL63047A (en) | 1984-07-31 |
| IE811269L (en) | 1981-12-09 |
| PT73154A (en) | 1981-07-01 |
| DE3169956D1 (en) | 1985-05-23 |
| GR74615B (pt) | 1984-06-29 |
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