DK2497505T3 - Sammensætninger og fremgangsmåder til skeletdannelse - Google Patents
Sammensætninger og fremgangsmåder til skeletdannelse Download PDFInfo
- Publication number
- DK2497505T3 DK2497505T3 DK12167510.2T DK12167510T DK2497505T3 DK 2497505 T3 DK2497505 T3 DK 2497505T3 DK 12167510 T DK12167510 T DK 12167510T DK 2497505 T3 DK2497505 T3 DK 2497505T3
- Authority
- DK
- Denmark
- Prior art keywords
- albumin
- synthetic polymers
- hydrogel
- scaffold
- skeleton
- Prior art date
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Claims (15)
- Sammensætninger og fremgangsmåder til skeletdannelse1. Substanssammensætning omfattende et precursormoiekyie, hvilken sammensætning omfatter ikke-thioleret albumin og mindst to syntetiske polymerer kovalent bundet til albuminet, hvor hver af de mindst to syntetiske polymerer har en funktionel gruppe, hvilken funktionel gruppe er udvalgt til at være i stand til tværbinding med en funktionel gruppe på mindst én anden syntetisk polymer ved kædepolvmerisatlon, hvor mindst én anden syntetisk polymer danner en del af mindst ét andet precursormoiekyie, der omfatter ikke-thioleret albumin og mindst to syntetiske polymerer, der er kovalent bundet til albuminet, hvilken tværbinding danner et skelet.
- 2. Skelet, der omfatter et antal ikke-thialaterede albuminmolekyler og et antal syntetiske polymerer, der er kovaient bundet til albuminmoiekyler, hvor hver af albuminmolekylerne er kovalent bundet til mindst to af de syntetiske polymerer, hvor de syntetiske polymerer er tværbundet ved kædepolymerisation.
- 3. Hydrogel dannet af skelettet ifølge krav 2.
- 4. Kosmetisk sammensætning, der omfatter hydrogel ifølge krav 3.
- 5. Fremgangsmåde til generering af et skelet, hvilken fremgangsmåde omfatter: (a) kovalent binding af ikke-thioleret albumin til mindst to syntetiske polymerer gennem en første funktionel gruppe på mindst to syntetiske polymerer, hvor hver af mindst to syntetiske polymerer har en sekundær funktionel gruppe for derved at opnå et precursormoiekyie, der omfatter albuminet og de syntetiske polymerer; og efterfølgende (b) tværbinding af et antal precursormolekyler ved kædepolymerisation af den anden funktionelle gruppe for derved at generere skelettet, hvorved fremgangsmåder til behandling af menneske- eller dyrekroppen ved hjælp af kirurgi eller terapi er udelukket.
- 6. Fremgangsmåde ifølge krav 5, hvor den første funktionelle gruppe af de syntetiske polymerer er kovalent bundet til en cysteinrest af albuminet.
- 7. Substanssammensætning ifølge krav 1, skelet ifølge krav 2 eller hydrogel ifølge krav 3 til anvendelse til reparation af vævsskade.
- 8. Substanssammensætning ifølge krav 1, skelet ifølge krav 2 eller hydrogel ifølge krav 3, hvor den syntetiske polymer er PEG,
- 9. Substanssammensætning ifølge krav 1, hvor den funktionelle gruppe er udvalgt fra gruppen bestående af acrylat og vinylsulfon.
- 10. Substanssammensætning ifølge krav 1, skelet ifølge krav 2, eller fremgangsmåde ifølge krav 5, hvor kædepolymerisationen resulterer i udskiftning af umættede bindinger i monomerer med bindinger, der forbinder monomerer,
- 11. Substanssammensætning ifølge krav I, skelet ifølge krav 2, eller hydrogel ifølge krav 3, hvor albuminet er denatureret.
- 12. Fremgangsmåde ifølge krav 5, hvor første og anden funktionelle gruppe er identiske,
- 13. Fremgangsmåde ifølge krav 5, hvor tværbindingen endvidere omfatter tværbinding af et antal precursormolekyler med et antal syntetiske polymerer, hvor hver af de syntetiske polymerer har mindst to funktionelle grupper, hvilke funktionelle grupper er valgt til at være i stand til tværbinding med en funktionel gruppe af p rec u rs ormo i e kvi e rn e.
- 14. Skelet ifølge krav 2, hydrogel ifølge krav 3, eller fremgangsmåde ifølge et hvilket som helst af kravene 5, 6, 12 og 13, hvor en koncentration af antallet af syntetiske polymerer ligger I området fra 1 mg/mi til 150 mg/ml.
- 15. Substanssammensætning, skelet eller hydrogel ifølge krav 7, hvor anvendelsen til reparation af vævsskade er en anvendelse som et klæbemiddel.
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| US90776507P | 2007-04-16 | 2007-04-16 | |
| EP08738223.0A EP2150282B1 (en) | 2007-04-16 | 2008-04-16 | Compositions and methods for scaffold formation |
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| DK2497505T3 true DK2497505T3 (da) | 2016-12-05 |
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| DK12167510.2T DK2497505T3 (da) | 2007-04-16 | 2008-04-16 | Sammensætninger og fremgangsmåder til skeletdannelse |
| DK08738223.0T DK2150282T3 (da) | 2007-04-16 | 2008-04-16 | Sammensætninger og fremgangsmåder til dannelse af et skelet |
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| DK08738223.0T DK2150282T3 (da) | 2007-04-16 | 2008-04-16 | Sammensætninger og fremgangsmåder til dannelse af et skelet |
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| US (2) | US9624259B2 (da) |
| EP (2) | EP2150282B1 (da) |
| DK (2) | DK2497505T3 (da) |
| ES (2) | ES2596707T3 (da) |
| PL (2) | PL2150282T3 (da) |
| PT (2) | PT2150282T (da) |
| TR (1) | TR201809112T4 (da) |
| WO (1) | WO2008126092A2 (da) |
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| WO2003031483A1 (en) | 2001-10-10 | 2003-04-17 | The Regents Of The University Of Colorado | Degradable thiol-ene polymers |
| ES2392061T3 (es) * | 2003-12-22 | 2012-12-04 | Regentis Biomaterials Ltd. | Matriz que comprende un esqueleto proteico de origen natural reticulado |
| US7842667B2 (en) | 2003-12-22 | 2010-11-30 | Regentis Biomaterials Ltd. | Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same |
| EP2150282B1 (en) | 2007-04-16 | 2018-04-11 | Regentis Biomaterials Ltd. | Compositions and methods for scaffold formation |
| HUE044239T2 (hu) | 2008-03-27 | 2019-10-28 | Purdue Research Foundation | Kollagén-kötõ szintetikus peptidoglikánok, elõállításuk és alkalmazási eljárásaik |
| WO2010064251A1 (en) | 2008-12-04 | 2010-06-10 | Technion Research & Development Foundation Ltd | Hydrogel sponges, methods of producing them and uses thereof |
| IL195764A0 (en) | 2008-12-07 | 2009-11-18 | Technion Res & Dev Foundation | Compositions and methods for drug delivery |
| EP2513294B1 (en) | 2009-12-16 | 2016-04-13 | Regentis Biomaterials Ltd. | Scaffolds formed from polymer-protein conjugates, methods of generating same and uses thereof |
| WO2012009377A2 (en) | 2010-07-12 | 2012-01-19 | University Of Southern California | Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same |
| US20140038826A1 (en) | 2011-01-28 | 2014-02-06 | The Regents Of The University Of Colorado, A Body Corporate | Covalently cross linked hydrogels and methods of making and using same |
| US10478206B2 (en) | 2011-04-29 | 2019-11-19 | University Of Southern California | Instruments and methods for the implantation of cell-seeded substrates |
| US8877489B2 (en) | 2011-12-05 | 2014-11-04 | California Institute Of Technology | Ultrathin parylene-C semipermeable membranes for biomedical applications |
| KR102006036B1 (ko) | 2011-05-24 | 2019-07-31 | 시믹 아이피, 엘엘씨 | 히알루론산-결합 합성 펩티도글리칸 및 이의 제조 및 이용 방법 |
| US9248013B2 (en) | 2011-12-05 | 2016-02-02 | California Institute Of Technology | 3-Dimensional parylene scaffold cage |
| US9988433B2 (en) | 2013-03-14 | 2018-06-05 | Mosaic Biosciences, Inc. | Covalent modification of biological macromolecules |
| WO2013116791A1 (en) | 2012-02-02 | 2013-08-08 | Mosaic Biosciences, Inc. | Biomaterials for delivery of blood extracts and methods of using same |
| SG11201506966RA (en) | 2013-03-15 | 2015-10-29 | Symic Biomedical Inc | Extracellular matrix-binding synthetic peptidoglycans |
| WO2015164822A1 (en) | 2014-04-25 | 2015-10-29 | Purdue Research Foundation | Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction |
| BR112017017029A2 (pt) * | 2015-02-09 | 2018-04-10 | Mosaic Biosciences Inc | polímeros de tiol-eno degradáveis e métodos para a sua fabricação |
| US20160303281A1 (en) * | 2015-04-17 | 2016-10-20 | Rochal Industries, Llc | Composition and kits for pseudoplastic microgel matrices |
| WO2017103914A1 (en) * | 2015-12-17 | 2017-06-22 | Regentis Biomaterials Ltd. | Ready for use organic solvent free compositions comprising protein-polymer conjugates and uses thereof |
| EP3436076A1 (en) | 2016-03-30 | 2019-02-06 | Regentis Biomaterials Ltd. | Treatments utilizing a polymer-protein conjugate |
| US11529424B2 (en) | 2017-07-07 | 2022-12-20 | Symic Holdings, Inc. | Synthetic bioconjugates |
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| SE431758B (sv) * | 1977-03-04 | 1984-02-27 | Pharmacia Fine Chemicals Ab | Som tioleringsreagens eller berarmatris for enzymer anvendbart derivat av en sh-grupphaltig polymer |
| US6284503B1 (en) * | 1993-08-20 | 2001-09-04 | University Of Utah Research Foundation | Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces |
| EP0705298B1 (en) | 1993-12-01 | 2002-03-27 | Bioartificial Gel Technologies Inc. | Albumin based hydrogel |
| WO2000051538A1 (en) * | 1999-03-01 | 2000-09-08 | Uab Research Foundation | Porous tissue scaffolding materials and uses thereof |
| US6680063B1 (en) * | 1999-10-08 | 2004-01-20 | Providence Health System-Oregon | Biocompatible albumin lamina and method |
| EP1368309B2 (en) * | 2001-02-22 | 2014-10-01 | Anika Therapeutics Inc. | Thiol-modified hyaluronan |
| US7345150B2 (en) * | 2002-03-26 | 2008-03-18 | Medical University Of Toledo | Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use |
| ZA200604869B (en) * | 2003-12-04 | 2007-11-28 | Univ Utah Res Found | Modified macromolecules and methods of making and using thereof |
| ES2392061T3 (es) | 2003-12-22 | 2012-12-04 | Regentis Biomaterials Ltd. | Matriz que comprende un esqueleto proteico de origen natural reticulado |
| EP2150282B1 (en) | 2007-04-16 | 2018-04-11 | Regentis Biomaterials Ltd. | Compositions and methods for scaffold formation |
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- 2008-04-16 WO PCT/IL2008/000521 patent/WO2008126092A2/en active Application Filing
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| PT2497505T (pt) | 2016-11-14 |
| EP2150282A2 (en) | 2010-02-10 |
| US20170182214A1 (en) | 2017-06-29 |
| ES2672510T3 (es) | 2018-06-14 |
| EP2150282B1 (en) | 2018-04-11 |
| US20100137510A1 (en) | 2010-06-03 |
| PT2150282T (pt) | 2018-07-09 |
| TR201809112T4 (tr) | 2018-07-23 |
| WO2008126092A3 (en) | 2009-10-22 |
| ES2596707T3 (es) | 2017-01-11 |
| EP2497505A1 (en) | 2012-09-12 |
| PL2497505T3 (pl) | 2017-02-28 |
| DK2150282T3 (da) | 2018-07-23 |
| US9624259B2 (en) | 2017-04-18 |
| EP2497505B1 (en) | 2016-08-10 |
| PL2150282T3 (pl) | 2018-10-31 |
| WO2008126092A2 (en) | 2008-10-23 |
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