DK2494959T3 - Skumbart dicarboxylsyrebærestof og farmaceutiske sammensætninger deraf - Google Patents
Skumbart dicarboxylsyrebærestof og farmaceutiske sammensætninger deraf Download PDFInfo
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- DK2494959T3 DK2494959T3 DK12162257.5T DK12162257T DK2494959T3 DK 2494959 T3 DK2494959 T3 DK 2494959T3 DK 12162257 T DK12162257 T DK 12162257T DK 2494959 T3 DK2494959 T3 DK 2494959T3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q13/00—Formulations or additives for perfume preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/04—Preparations for care of the skin for chemically tanning the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Claims (13)
1. Farmaceutisk eller kosmetisk sammensætning omfattende: a. en gavnlig eller terapeutisk effektiv koncentration af azelainsyre; b. et stabiliseringsmiddel, der er udvalgt fra gruppen bestående af mindst ét overfladeaktivt middel; mindst ét polymermiddel og blandinger deraf; og kendetegnet ved, at sammensætningen endvidere omfatter et organisk opløsningsmiddel omfattende caprin/capryltriglycerid og endvidere omfatter mindst ét polært bæremiddel, der er udvalgt fra gruppen bestående af dimethylisosorbid, glycerol, propylenglycol, hexylenglycol, terpen-ol, oleylalkohol, mælkesyre og glycolsyre; hvor polymermidlet er ca. 0,01 % til ca. 5 vægt-% og er udvalgt fra gruppen bestående af et biologisk klæbemiddel, et geleringsmiddel, et filmdannende middel og et faseændringsmiddel; hvor azelainsyren, stabiliseringsmidlet og opløsningsmidlet er udvalgt til at tilvejebringe en sammensætning, der i alt væsentligt er modstandsdygtig over for ældning og for faseseparation og eller i alt væsentligt kan stabilisere andre aktive bestanddele; og hvor, hvis sammensætningen er indeholdt i en beholder under tryk og endvidere omfatter et flydende, luftformigt hydrohydriddrivmiddel ved en koncentration på ca. 3 % til ca. 25 vægt-% af den totale sammensætning, sammensætningen i alt væsentligt er flydende og tilvejebringer skum efter frigivelse.
2. Sammensætning ifølge krav 1, hvor sammensætningen er indeholdt i en beholder under tryk og endvidere omfatter et flydende luftformigt hydrohydriddrivmiddel ved en koncentration på ca. 3 % til ca. 25 vægt-% af den totale sammensætning, i alt væsentligt er flydende og tilvejebringer skum efter frigivelse, og hvor azelainsyren, stabiliseringsmidlet og opløsningsmidler er udvalgt til at generere et skrøbeligt skum af god til enestående kvalitet.
3. Sammensætning ifølge krav 1, hvor det overfladeaktive middel er udvalgt fra gruppen bestående af et polysorbat, polyoxyethylen (20) sorbitanmonostearat, polyoxyethylen (20) sorbitanmonooleat, en polyoxyethylenfedtsyreester, Myrj 45, Myrj 49, Myrj 52, PEG-100 stearat, en polyoxyethylenalkylether, polyoxyethylencetylether, brij 38, PEG-2 cetylether, brij 56, brij Wl, en saccharoseester, en partiel ester af sorbitol, sorbitanmonolaurat, et monoglycerid, et diglycerid, isoceteth-20, steareth 2, glycerylmonostearat, steareth-21, PEG 40 stearat, sorbitanstearat, laureth 4, sorbitanmonooleat, ceteareth 20, steareth 20, ceteth 20, macrogolcetostearylether, ceteth 2, PEG-30 dipolyhydroxystearat, saccharosedistearat, cetomacrogolether, cetearylglucosid, polysorbat 20, methylsaccharosesesquistearat, PEG 30 dipolyhydroxystearat, saccharose-stearinsyreestere og blandinger deraf.
4. Sammensætning ifølge krav 1, hvor det overfladeaktive middel er udvalgt fra gruppen bestående af en ikke-ethoxyleret sorbitanester, en glycerolfedtsyreester, en saccharoseester, et alkylpolyglycosid eller er udvalgt fra gruppen bestående af sorbitanmonopalmitat, sorbitanmonostearat, sorbitantristearat, sorbitanmonooleat, sorbitantrioleat, sorbitanmonolaurat, sorbitansesquioleat, glycerolmonostearat, glycerolmonooleat, saccharosestearat, saccharosedistearat, saccharosepalmitat, saccharoselaurat og lauryldiglucosid.
5. Sammensætning ifølge krav 1, hvor polymermidlet er udvalgt fra gruppen bestående af carbopol 934, pemulen TR2, xanthangummi, carboxymethylcellulose, johannesbrødkememel, natriumalginat, natriumcaseinat, ægalbumin, gelatine agar, carrageeningummi, ekstrakt fra kvædefrø, tragacanthgummi, guargummi, kationisk guar, hydroxypropylguargummi, stivelse, en amin-bærende polymer, chitosan, alginsyre, hyaluronsyre, kemisk modificeret stivelse, en carboxyvinylpolymer, polyvinylpyrrolidon, polyvinylalkohol, en polyacrylsyrepolymer, en polymethacrylsyrepolymer, polyvinylacetat, en polyvinylchloridpolymer, en polyvinylidenchloridpolymer, methylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, methylhydroxyethylcellulose, methylhydroxypropylcellulose, hydroxyethylcarboxymethylcellulose, carboxymethylcellulose, carboxymethylhydrox-yethylcellulose, en kationisk cellulose, aluminiumstivelse-octenylsuccinat (ASOS), PEG 1000, PEG 4000, PEG 6000 og PEG 8000.
6. Sammensætning ifølge krav 1, hvor det mindst ene polære bærestof er dimethylisosorbid eller propylenglycol, og hvor stabiliseringsmidlet er methylcellulose eller xanthangummi.
7. Sammensætning ifølge krav 2, hvilken sammensætning endvidere indeholder et skumtilsætningsstof, der er udvalgt fra gruppen bestående af en fedtalkohol med 15 eller flere carboner i carbonkæden; en fedtsyre med 16 eller flere carboner i carbonkæden; fedtalkoholer, afledt af bivoks og indbefattende en blanding af alkoholer, hvoraf størstedelen har mindst 20 carbonatomer i carbonkæden; en fedtalkohol med mindst én dobbeltbinding; en fedtsyre med mindst én dobbeltbinding; en forgrenet fedtalkohol; en forgrenet fedtsyre og en fedtsyre substitueret med en hydroxylgruppe.
8. Sammensætning ifølge krav 1, hvor koncentrationen af azelainsyre er mellem 5 % og 25 %.
9. Sammensætning ifølge krav 1, hvor sammensætningens pH er under 5,ΒΙΟ. Sammensætning ifølge krav 1, hvilken sammensætning endvidere omfatter en ekstra bestanddel, der er udvalgt fra gruppen bestående af et moduleringsmiddel, et polært opløsningsmiddel, en antiperspirant, et antistatisk middel, et buffermiddel, et fyldemiddel, et chelateringsmiddel, et farvestof, et konditioneringsmiddel, en deodorant, et fortyndingsmiddel, en farve, et blødgøringsmiddel, et duftstof, et befugtningsmiddel, et okklusionsmiddel, et penetreringsfremmende middel, et parfumeringsmiddel, et indtrængningsfremmende middel, et pH-justerende middel, et konserveringsmiddel, et hudpenetreringsfremmende middel, en solcreme, en solblokker, et selvbrunende middel og et vitamin.
11. Sammensætning ifølge krav 1, hvilken sammensætning består af (% vægt/vægt)
12. Anvendelse af sammensætningen ifølge et hvilket som helst af kravene 1 til 11 til fremstilling af et medikament til anvendelse i behandlingen af dermatologiske forstyrrelser.
13. Anvendelse af sammensætningen ifølge krav 11 til fremstilling af et medikament til anvendelse i behandlingen af en hudforstyrrelse, der er udvalgt fra akne, rosacea, en pigmenteringsforstyrrelse, en celledelingsabnormitet, en hudinfektion og en hudbetændelse.
14. Sammensætning ifølge et hvilket som helst af kravene 1 til 11 til behandling af en dermatologisk forstyrrelse.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81863406P | 2006-07-05 | 2006-07-05 | |
EP07858941A EP2051697A2 (en) | 2006-07-05 | 2007-07-05 | Foamable vehicle comprising dicarboxylic acid or dicarboxylic acid ester and pharmaceutical compositions thereof |
Publications (1)
Publication Number | Publication Date |
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DK2494959T3 true DK2494959T3 (da) | 2015-02-23 |
Family
ID=39230604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12162257.5T DK2494959T3 (da) | 2006-07-05 | 2007-07-05 | Skumbart dicarboxylsyrebærestof og farmaceutiske sammensætninger deraf |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP2051697A2 (da) |
DK (1) | DK2494959T3 (da) |
ES (1) | ES2530390T3 (da) |
HK (1) | HK1175403A1 (da) |
IL (1) | IL196363A (da) |
PL (1) | PL2494959T3 (da) |
PT (1) | PT2494959E (da) |
SI (1) | SI2494959T1 (da) |
WO (1) | WO2008038147A2 (da) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
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US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
CA2502986C (en) | 2002-10-25 | 2011-08-23 | Foamix Ltd. | Cosmetic and pharmaceutical foam |
US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
DE602006006432D1 (de) | 2005-03-24 | 2009-06-04 | Nolabs Ab | Kosmetische behandlung mit stickoxid, vorrichtung zur durchführung dieser behandlung und herstellungsverfahren dafür |
US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
JP5292304B2 (ja) | 2006-12-01 | 2013-09-18 | アンテリオス, インコーポレイテッド | ペプチドナノ粒子およびその使用 |
WO2008070538A2 (en) | 2006-12-01 | 2008-06-12 | Anterios, Inc. | Micellar nanoparticles comprising botulinum toxin |
KR20150028856A (ko) | 2007-05-31 | 2015-03-16 | 안테리오스, 인코퍼레이티드 | 핵산 나노입자 및 이의 용도 |
US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
US9439857B2 (en) | 2007-11-30 | 2016-09-13 | Foamix Pharmaceuticals Ltd. | Foam containing benzoyl peroxide |
WO2010041141A2 (en) | 2008-10-07 | 2010-04-15 | Foamix Ltd. | Oil-based foamable carriers and formulations |
WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
AU2009205314A1 (en) | 2008-01-14 | 2009-07-23 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
EP2116237A1 (en) * | 2008-08-05 | 2009-11-11 | Polichem SA | Compositions for treating rosacea comprising chitosan and a dicarboxylic acid |
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ES2530390T3 (es) | 2015-03-02 |
WO2008038147A2 (en) | 2008-04-03 |
HK1175403A1 (en) | 2013-07-05 |
PT2494959E (pt) | 2015-02-20 |
IL196363A0 (en) | 2009-09-22 |
SI2494959T1 (sl) | 2015-04-30 |
EP2494959B1 (en) | 2014-11-19 |
EP2051697A2 (en) | 2009-04-29 |
PL2494959T3 (pl) | 2015-06-30 |
EP2494959A1 (en) | 2012-09-05 |
IL196363A (en) | 2014-04-30 |
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