DK2482897T3 - Indretning og stempelstang til lægemiddelfremføringsanordning - Google Patents

Indretning og stempelstang til lægemiddelfremføringsanordning Download PDF

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DK2482897T3
DK2482897T3 DK10763656.5T DK10763656T DK2482897T3 DK 2482897 T3 DK2482897 T3 DK 2482897T3 DK 10763656 T DK10763656 T DK 10763656T DK 2482897 T3 DK2482897 T3 DK 2482897T3
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piston rod
dose
interaction
section
drive
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DK10763656.5T
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Catherine Anne Macdonald
Robert Veasey
Christopher Jones
Garen Kouyoumjian
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Sanofi Aventis Deutschland
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3146—Priming, e.g. purging, reducing backlash or clearance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31555—Mechanically operated dose setting member by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31573—Accuracy improving means
    • A61M5/31575—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe
    • A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe
    • A61M2005/2492—Ampoule holder connected to rest of syringe via snap connection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (13)

1. Drivmekanisme til en lægemiddelfremføringsanordning (1), der omfatter 5 - et hus (2) , - en drivdel (5), hvilken drivdel (5) er konfigureret til at blive aksialt forskudt i en dosisindstillingsretning i forhold til huset (2) til indstilling af en dosis af et lægemiddel (24) og til at blive aksialt forskudt i en 10 dosisfremføringsretning i forhold til huset (2) til fremføring af den indstillede dosis af lægemidlet (24), hvilken drivdel (5) omfatter et drivtræk (15), en stempelstangsindretning (32), hvilken stempelstangsindretning (32) omfatter et sæt af 15 interaktionsflader (17) til mekanisk interaktion med drivtrækket (15), hvor mindst to interaktionsflader (17) er aksialt og vinkelmæssigt forskudt i forhold til hinanden, og er kendetegnet ved, at drivmekanismen er konfigureret, således at, når drivdelen (5) forskydes i 20 dosisfremføringsretningen til fremføring af den indstillede dosis, interagerer drivtrækket (15) mekanisk med én af interaktionsfladerne (17), og stempelstangsindretningen (32) roterer i forhold til huset (2) til derved rotation og aksial forskydning af en anden af interaktionsfladerne (17) fra en 25 ikke-interaktionsposition til en interaktionsposition, hvor drivtrækket (15) kan interagere med den anden af interaktionsfladerne (17), når drivmekanismen aktueres endnu en gang til indstilling og fremføring af en yderligere dosis.
2. Drivmekanisme ifølge krav 1, hvor drivdelen (5) er sikret mod rotationsbevægelse i forhold til huset (2), og den anden af interaktionsfladerne (17) roteres og forskydes aksialt til den position, den ene interaktionsflade (17) af interaktionsfladerne (17) havde før 35 forskydning af drivdelen (5) i dosisfremføringsretningen.
3. Drivmekanisme ifølge krav 1 eller krav 2, hvor drivdelen (5) er en fleksibel del, og hvor drivdelen (5), når den forskydes i dosisindstillingsretningen, forskydes mod den anden af interaktionsfladerne (17), idet drivdelen (5) afbøjes elastisk omkring en længdegående akse (28) ved mekanisk interaktion mellem drivtrækket (15) og 5 stempelstangsindretningen (32) .
4. Drivmekanisme ifølge krav 3, hvor to tilgrænsende interaktionsflader (17) af sættet af interaktionsflader (17) er forbundet via en rampe (31), og 10 hvor drivdelen (5), når den forskydes i dosisindstillingsretningen, afbøjes elastisk, når drivtrækket (15) styres langs rampen (31).
5. Drivmekanisme ifølge et hvilket som helst af ovennævnte 15 krav, hvor stempelstangsindretningen (32) er sikret mod rotation i forhold til huset (2), når drivdelen (5) forskydes i dosisindstillingsretningen i forhold til stempelstangsindretningen (32). 20
6. Drivmekanisme ifølge et hvilket som helst af ovennævnte krav, hvor stempelstangsindretningen (32) omfatter mindst ét styrespor (18), der løber langs stempelstangsindretningen 25 (32), og hvor drivmekanismen omfatter en interaktionsdel (23), hvilken interaktionsdel (23) er rotationsmæssigt og aksialt fikseret i forhold til huset (2) og er konfigureret til at samvirke med styresporet (18), hvor styresporet (18) omfatter mindst én fremføringssektion (18A), hvilken fremføringssektion 30 (18A) er skrå i forhold til en længdegående hovedakse (28) af stempelstangsindretningen (32), hvor stempelstangsindretningen (32), når drivdelen (5) forskydes i dosisfremføringsretningen, roteres ved mekanisk interaktion mellem interaktionsdelen (23) og fremføringssektionen (18A). 35
7. Drivmekanisme ifølge krav 6, hvor stempelstangsindretningen (32) roteres med 45 grader eller mindre til fremføring af den indstillede dosis.
8. Drivmekanisme ifølge krav 6 eller krav 7, hvor fremføringssektionen (18A) omfatter mindst ét blokeringsmiddel (19), hvilket blokeringsmiddel (19) 5 forhindrer aksial forskydning af stempelstangsindretningen (32) i dosisindstillingsretningen, når den samvirker mekanisk med interaktionsdelen (23) .
9. Drivmekanisme ifølge krav 8, 10 hvor fremføringssektionen (18A) omfatter et antal dosissektioner, hvor to tilgrænsende dosissektioner er adskilt af blokeringsmidlet (19).
10. Drivmekanisme ifølge et hvilket som helst af kravene 8 15 til 9, hvor styresporet (18) omfatter mindst én nulstillingssektion (18B), hvilken nulstillingssektion (18B) er anbragt, så den fortsætter fremføringssektionen (18A), og hvilken nulstillingssektion (18B) er vinkelmæssigt forskudt i forhold 20 til fremføringssektionen (18A), således at blokeringsmidlet (19) kan passere den aksiale position af interaktionsdelen (23) med en vinkelmæssig forskydning, når interaktionsdelen (23) samvirker med nulstillingssektionen (18B).
11. Drivmekanisme ifølge krav 10, hvor nulstillingssektionen (18B) strækker sig aksialt langs fremføringssektionen (18A).
12. Drivmekanisme ifølge krav 10 eller krav 11, 30 hvor den ene ende af nulstillingssektionen (18B) er forbundet til den ene ende af fremføringssektionen (18A) , og en anden ende af nulstillingssektionen (18B) er forbundet enten til en anden ende af fremføringssektionen (18A) eller til en ende af en anden fremføringssektion (18A). 35
13. Drivmekanisme ifølge et hvilket som helst af kravene 6 til 12, hvor stempelstangsindretningen (32) har en indre overflade og en ydre overflade, idet styresporet (18) er tilvejebragt på den ene af den indre overflade og den ydre overflade, og sættet af interaktionsflader (17) er tilvejebragt på den anden af den indre overflade og den ydre overflade.
DK10763656.5T 2009-09-30 2010-09-29 Indretning og stempelstang til lægemiddelfremføringsanordning DK2482897T3 (da)

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EP09171742 2009-09-30
PCT/EP2010/064400 WO2011039209A1 (en) 2009-09-30 2010-09-29 Assembly and piston rod for a drug delivery device

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DK2482897T3 true DK2482897T3 (da) 2016-05-23

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US (1) US20120283652A1 (da)
EP (1) EP2482897B1 (da)
JP (1) JP5752693B2 (da)
CA (1) CA2774565A1 (da)
DK (1) DK2482897T3 (da)
WO (1) WO2011039209A1 (da)

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AR078459A1 (es) * 2009-09-30 2011-11-09 Sanofi Aventis Deutschland Conjunto de accionamiento, vastago de piston, dispositivo para la entrega de drogas, y uso de un resorte
DK2482884T3 (da) * 2009-09-30 2016-02-08 Sanofi Aventis Deutschland Lægemiddelfremføringsanordning og drivdel til en lægemiddelfremføringsanordning
BR112012013767A2 (pt) * 2009-12-07 2016-04-26 Sanofi Aventis Deutschland montagem de acionamento para um dispositivo de entrega de fármaco e dispositivo de entrega de fármaco
JP5903102B2 (ja) * 2010-09-24 2016-04-13 イーライ リリー アンド カンパニー 用量送達装置

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JP2013506448A (ja) 2013-02-28
EP2482897A1 (en) 2012-08-08
EP2482897B1 (en) 2016-02-17
US20120283652A1 (en) 2012-11-08
JP5752693B2 (ja) 2015-07-22
CA2774565A1 (en) 2011-04-07

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