DK2368903T3 - Adenovirusafledt hjælpevirus til fremme af produktion af rekombinant parvovirus - Google Patents

Adenovirusafledt hjælpevirus til fremme af produktion af rekombinant parvovirus

Info

Publication number
DK2368903T3
DK2368903T3 DK10003296.0T DK10003296T DK2368903T3 DK 2368903 T3 DK2368903 T3 DK 2368903T3 DK 10003296 T DK10003296 T DK 10003296T DK 2368903 T3 DK2368903 T3 DK 2368903T3
Authority
DK
Denmark
Prior art keywords
adenovirus
promote production
recombinant parvovirus
auxiliary virus
derived auxiliary
Prior art date
Application number
DK10003296.0T
Other languages
English (en)
Inventor
Nazim El-Andaloussi
Antonio Marchini
Jean Rommelaere
Max Endele
Barbara Leuchs
Original Assignee
Deutsches Krebsforsch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch filed Critical Deutsches Krebsforsch
Application granted granted Critical
Publication of DK2368903T3 publication Critical patent/DK2368903T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/864—Parvoviral vectors, e.g. parvovirus, densovirus
    • C12N15/8645—Adeno-associated virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13—Tumour cells, irrespective of tissue of origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10344—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14311—Parvovirus, e.g. minute virus of mice
    • C12N2750/14341—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14311—Parvovirus, e.g. minute virus of mice
    • C12N2750/14341—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14344—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14311—Parvovirus, e.g. minute virus of mice
    • C12N2750/14351—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14311—Parvovirus, e.g. minute virus of mice
    • C12N2750/14351—Methods of production or purification of viral material
    • C12N2750/14352—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
DK10003296.0T 2010-03-26 2010-03-26 Adenovirusafledt hjælpevirus til fremme af produktion af rekombinant parvovirus DK2368903T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10003296.0A EP2368903B1 (en) 2010-03-26 2010-03-26 Adenovirus derived helper virus for enhancing recombinant parvovirus production

Publications (1)

Publication Number Publication Date
DK2368903T3 true DK2368903T3 (da) 2014-05-05

Family

ID=42537981

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10003296.0T DK2368903T3 (da) 2010-03-26 2010-03-26 Adenovirusafledt hjælpevirus til fremme af produktion af rekombinant parvovirus
DK11716475.6T DK2552943T3 (da) 2010-03-26 2011-03-24 Effektiv fremstilling af rekombinante autonome parvovira ved brug af en fra adenovirus afledt hjælper-vektor

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK11716475.6T DK2552943T3 (da) 2010-03-26 2011-03-24 Effektiv fremstilling af rekombinante autonome parvovira ved brug af en fra adenovirus afledt hjælper-vektor

Country Status (8)

Country Link
US (1) US9803219B2 (da)
EP (2) EP2368903B1 (da)
JP (1) JP5829265B2 (da)
AU (1) AU2011231998B2 (da)
CA (1) CA2794383C (da)
DK (2) DK2368903T3 (da)
ES (2) ES2461147T3 (da)
WO (1) WO2011116974A2 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2368903B1 (en) * 2010-03-26 2014-03-05 Deutsches Krebsforschungszentrum Adenovirus derived helper virus for enhancing recombinant parvovirus production
EP2620503B1 (en) * 2012-01-27 2014-10-22 Deutsches Krebsforschungszentrum Modified parvovirus useful for gene silencing
EP3327124A1 (en) * 2016-11-28 2018-05-30 Deutsches Krebsforschungszentrum H-1 pv expressing rnai effectors targeting cdk9
WO2022007800A1 (zh) * 2020-07-06 2022-01-13 嘉兴安宇生物科技有限公司 一种非洲猪瘟的重组腺病毒疫苗及其构建方法
KR20230152768A (ko) * 2021-05-27 2023-11-03 주식회사 뉴라클제네틱스 신규한 듀얼 헬퍼 플라스미드

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004797A (en) * 1995-11-09 1999-12-21 Avigen, Inc. Adenovirus helper-free recombinant AAV Virion production
DE69834813T2 (de) * 1998-10-14 2007-05-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Parvovirus-Vektoren und deren Verwendung
AU7841400A (en) * 1999-10-01 2001-05-10 Genovo, Incorporated Production of recombinant aav using adenovirus comprising aav rep/cap genes
US7115391B1 (en) 1999-10-01 2006-10-03 Genovo, Inc. Production of recombinant AAV using adenovirus comprising AAV rep/cap genes
CA2369985A1 (en) * 2002-01-18 2003-07-18 Duke University Generation of recombinant adeno-associated viral vectors by a complete adenovirus-mediated approach
EP2368903B1 (en) * 2010-03-26 2014-03-05 Deutsches Krebsforschungszentrum Adenovirus derived helper virus for enhancing recombinant parvovirus production

Also Published As

Publication number Publication date
EP2552943A2 (en) 2013-02-06
WO2011116974A3 (en) 2012-01-05
DK2552943T3 (da) 2018-08-13
ES2683002T3 (es) 2018-09-24
EP2368903B1 (en) 2014-03-05
EP2368903A1 (en) 2011-09-28
AU2011231998A1 (en) 2012-10-25
AU2011231998B2 (en) 2015-07-02
US20130089523A1 (en) 2013-04-11
WO2011116974A2 (en) 2011-09-29
EP2552943B1 (en) 2018-05-09
CA2794383A1 (en) 2011-09-29
JP2013539957A (ja) 2013-10-31
US20170073704A9 (en) 2017-03-16
CA2794383C (en) 2015-12-01
JP5829265B2 (ja) 2015-12-09
ES2461147T3 (es) 2014-05-16
US9803219B2 (en) 2017-10-31

Similar Documents

Publication Publication Date Title
SMT201500197B (it) Imidazolilimidazoli condensati come composti antivirali
DK2560683T4 (da) Fremstilling af heteromultimeriske proteiner
DK2903498T3 (da) Forbedringer af eller relaterende til scanning-laseroftalmoskoper
DK2760994T4 (da) Forbindelser til forøget viral transduktion
DK3444335T3 (da) Forbedrede fremgangsmåder til oprensning af rekombinante aav-vektorer
DK2771364T3 (da) Fremstilling af heterodimere proteiner
BR112013017629A2 (pt) laminina-521 recombinante
DK2896405T3 (da) Fremstilling af gadobutrol med høj renhed
DK3435582T3 (da) Udvidelse af ue-rs til dwpts
DK3486677T3 (da) Positioneringsmellemrumsindikation til forbedring af udførelse af positionering
DK2890836T3 (da) Fremgangsmåder i forbindelse med modulatorer af eukaryotiske celler
DK2422547T3 (da) Indikator af PS- til CS-handover
DK2633007T3 (da) Produktion af regenererbar biobenzin
DK2425000T3 (da) Sammensætninger rettet mod ledende luftvejsceller omfattende konstrukter af adeno-associeret virus
BR112014000360A2 (pt) análogos de heterociclil pirimidina como inibidores jak
DK2398794T3 (da) Hæmmere af hepatitis C-virus
DK2411028T3 (da) Terapi til fremme af cellevækst
DK2603219T3 (da) Kombination af GLYT1-forbindelse med antipsykotika
FR2965209B1 (fr) Renfort composite auto-adherent
DK2349314T3 (da) Lyofiliserede præparater af rekombinant VWF
DK2526114T3 (da) Kromatografisk fremgangsmåde til oprensning af FC-indeholdende proteiner
DK2841606T3 (da) Fusionsproteiner til at lette selektionen af celler inficeret med specifikt immunoglobulingenrekombinant vacciniavirus
DK2260873T3 (da) Pcylering af proteiner
DK2898890T3 (da) Stabilisering af viruspartikler
DK3372280T3 (da) Forbedringer af eller vedrørende synsevnen