DK2327414T3 - Precursor for N-acetylgalactosamine-4-sulfatase, methods of treatment using the enzyme and methods of preparation and purification of the enzyme - Google Patents

Precursor for N-acetylgalactosamine-4-sulfatase, methods of treatment using the enzyme and methods of preparation and purification of the enzyme Download PDF

Info

Publication number
DK2327414T3
DK2327414T3 DK10011421.4T DK10011421T DK2327414T3 DK 2327414 T3 DK2327414 T3 DK 2327414T3 DK 10011421 T DK10011421 T DK 10011421T DK 2327414 T3 DK2327414 T3 DK 2327414T3
Authority
DK
Denmark
Prior art keywords
sulfatase
acetylgalactosamine
precursor
human
purity
Prior art date
Application number
DK10011421.4T
Other languages
Danish (da)
English (en)
Inventor
Minmin Qin
Wai-Pan Chan
Lin Chen
Stuart Swiedler
John M Henstrand
Gary N Zecherle
Dan J Wendt
Paul A Fitzpatrick
Christopher M Starr
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Application granted granted Critical
Publication of DK2327414T3 publication Critical patent/DK2327414T3/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804Affinity chromatography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32Bonded phase chromatography
    • B01D15/325Reversed phase
    • B01D15/327Reversed phase with hydrophobic interaction
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804Affinity chromatography
    • B01D15/3828Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/06Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06012N-Acetylgalactosamine-4-sulfatase (3.1.6.12)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
DK10011421.4T 2002-11-07 2003-11-07 Precursor for N-acetylgalactosamine-4-sulfatase, methods of treatment using the enzyme and methods of preparation and purification of the enzyme DK2327414T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/290,908 US6866844B2 (en) 2002-11-07 2002-11-07 Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
EP03783223.5A EP1565209B1 (en) 2002-11-07 2003-11-07 Precursor n-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme

Publications (1)

Publication Number Publication Date
DK2327414T3 true DK2327414T3 (en) 2015-04-13

Family

ID=32312121

Family Applications (1)

Application Number Title Priority Date Filing Date
DK10011421.4T DK2327414T3 (en) 2002-11-07 2003-11-07 Precursor for N-acetylgalactosamine-4-sulfatase, methods of treatment using the enzyme and methods of preparation and purification of the enzyme

Country Status (17)

Country Link
US (1) US6866844B2 (OSRAM)
EP (2) EP2327414B1 (OSRAM)
JP (1) JP4459059B2 (OSRAM)
CN (1) CN100374157C (OSRAM)
AR (1) AR042019A1 (OSRAM)
AU (1) AU2003290642B2 (OSRAM)
BR (1) BRPI0316039B1 (OSRAM)
CA (1) CA2502928C (OSRAM)
CY (1) CY1116164T1 (OSRAM)
DK (1) DK2327414T3 (OSRAM)
ES (2) ES2533770T3 (OSRAM)
IL (1) IL168435A (OSRAM)
MX (1) MXPA05004880A (OSRAM)
PT (2) PT2327414E (OSRAM)
SI (1) SI2327414T1 (OSRAM)
TW (1) TWI327919B (OSRAM)
WO (1) WO2004043373A2 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6972124B2 (en) * 2000-05-01 2005-12-06 Biomarin Pharmaceuticals Inc. Precursor of N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
US7713709B2 (en) * 2006-03-17 2010-05-11 Biomarin Pharmaceutical Inc. Assay for detection of antibodies to lysosomal enzymes
CN101539550B (zh) * 2009-04-28 2012-05-23 李绍平 用于多糖的定性与定量分析方法
PT3626258T (pt) 2010-06-25 2021-10-19 Shire Human Genetic Therapies Métodos e composições para fornecimento ao snc de iduronato-2-sulfatase
NZ605873A (en) 2010-06-25 2015-02-27 Shire Human Genetic Therapies Methods and compositions for cns delivery of arylsulfatase a
EP2606142B1 (de) * 2010-08-20 2018-02-28 Boehringer Ingelheim International GmbH Verfahren zur inaktivierung von proteasen in einer aus einer zellkultur gewonnen flüssigkeit durch ph änderung
EP2799862B1 (en) 2011-12-20 2017-03-08 JCR Pharmaceuticals CO., LTD. Method for analyzing formyl glycine residue
WO2013096899A2 (en) 2011-12-23 2013-06-27 Shire Human Genetic Therapies, Inc. Stable formulations for cns delivery of arylsulfatase a
EP3041593B1 (en) * 2013-09-05 2025-01-29 F. Hoffmann-La Roche AG Method of cleaning a chromatography material for its reuse
FR3011468B1 (fr) * 2013-10-04 2015-12-04 Inventiva Utilisation de l'odiparcil dans le traitement d'une mucopolysaccharidose
US11584777B2 (en) 2017-08-31 2023-02-21 Green Cross Corporation Method for purifying a sulfatase protein
AR119264A1 (es) * 2019-06-05 2021-12-09 Genentech Inc Método para reutilización de cromatografía

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL281225A (OSRAM) 1961-07-20
US3472931A (en) 1969-01-17 1969-10-14 Foster Milburn Co Percutaneous absorption with lower alkyl amides
US3891757A (en) 1971-11-11 1975-06-24 Alza Corp Anaesthetic topical and percutaneous administration with selected promoters
SE387536B (sv) 1973-03-13 1976-09-13 Astra Laekemedel Ab Forfarande for framstellning av en lokalanestetisk beredning
AU5577101A (en) 2000-05-01 2001-11-12 Biomarin Pharmaceuticals Enzymes useful for treating and methods for treating mps-vi and cells lines for producing such enzymes recombinantly

Also Published As

Publication number Publication date
IL168435A (en) 2014-07-31
TW200427459A (en) 2004-12-16
BRPI0316039B1 (pt) 2017-08-29
BR0316039A (pt) 2005-09-13
HK1157215A1 (en) 2012-06-29
EP2327414A1 (en) 2011-06-01
EP2327414B1 (en) 2015-01-07
CN1726046A (zh) 2006-01-25
EP1565209A4 (en) 2008-01-02
CA2502928C (en) 2013-07-16
EP1565209B1 (en) 2013-11-06
ES2445028T3 (es) 2014-02-27
WO2004043373A2 (en) 2004-05-27
AU2003290642A1 (en) 2004-06-03
JP4459059B2 (ja) 2010-04-28
PT2327414E (pt) 2015-04-13
JP2006510356A (ja) 2006-03-30
TWI327919B (en) 2010-08-01
US6866844B2 (en) 2005-03-15
ES2533770T3 (es) 2015-04-15
MXPA05004880A (es) 2005-07-22
SI2327414T1 (sl) 2015-05-29
EP1565209A2 (en) 2005-08-24
PT1565209E (pt) 2014-02-13
CA2502928A1 (en) 2004-05-27
CN100374157C (zh) 2008-03-12
WO2004043373A3 (en) 2004-08-05
AU2003290642B2 (en) 2008-07-10
BRPI0316039B8 (OSRAM) 2021-05-25
CY1116164T1 (el) 2017-02-08
US20040101524A1 (en) 2004-05-27
AR042019A1 (es) 2005-06-08

Similar Documents

Publication Publication Date Title
US20080260715A1 (en) Precursor N-acetylgalactosamine-4 sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
DK2327414T3 (en) Precursor for N-acetylgalactosamine-4-sulfatase, methods of treatment using the enzyme and methods of preparation and purification of the enzyme
RU2248213C2 (ru) ЛЕЧЕНИЕ α-ГАЛАКТОЗИДАЗНОЙ А НЕДОСТАТОЧНОСТИ
JP3857705B2 (ja) 組換えα−L−イズロニダーゼ、その生成及び精製方法及びその欠失により引き起こされる疾病の処理方法
JP7193476B2 (ja) 組換えヒト酸性アルファグリコシダーゼ
RU2751235C2 (ru) Терапевтические слитые белки направленного действия на основе лизосомных ферментов, соответствующие составы и их применения
CA2443555C (en) Enzymes useful for treating and methods for treating mps-vi and cells lines for producing such enzymes recombinantly
AU2001255771A1 (en) Enzymes useful for treating and methods for treating MPS-VI and cell lines for producing such enzymes recombinantly
CN1300323A (zh) 重组α-L-艾杜糖苷酸酶,其生产和纯化的方法以及治疗其缺乏导致的疾病的方法
HK1079713A (en) Precursor n-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
HK1079713B (en) Precursor n-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
HK1157215B (en) Precursor n-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
CN114341333A (zh) 用于捕获和纯化生物制品的方法
RU2830306C2 (ru) Очищенная арилсульфатаза a и композиции на ее основе
HK40072878A (en) Method for capturing and purification of biologics
Kakkis α-L-Iduronidase: the development of Aldurazyme (Laronidase)
HK40037124A (en) Purified arylsulfatase a and compositons thereof