DK2255173T3 - Optisk fremgangsmåde til at bestemme morfologiske parametre og fysiologiske egenskaber af hudvæv - Google Patents

Optisk fremgangsmåde til at bestemme morfologiske parametre og fysiologiske egenskaber af hudvæv Download PDF

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Publication number
DK2255173T3
DK2255173T3 DK09722309.3T DK09722309T DK2255173T3 DK 2255173 T3 DK2255173 T3 DK 2255173T3 DK 09722309 T DK09722309 T DK 09722309T DK 2255173 T3 DK2255173 T3 DK 2255173T3
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DK
Denmark
Prior art keywords
tissue
morphological parameters
physiological properties
skin tissue
lesion
Prior art date
Application number
DK09722309.3T
Other languages
English (en)
Inventor
Jakob J Stamnes
Boerge Hamre
Gennady Ryzhikov
Marina Biryulina
Endre R Sommersten
Kristian P Nielsen
Johan E Moan
Knut Stamnes
Lu Zhao
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Balter Inc
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Publication of DK2255173T3 publication Critical patent/DK2255173T3/da

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/60—Analysis of geometric attributes
    • G06T7/62—Analysis of geometric attributes of area, perimeter, diameter or volume
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/60—Analysis of geometric attributes
    • G06T7/66—Analysis of geometric attributes of image moments or centre of gravity
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/693—Acquisition
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro

Claims (6)

1. Optisk fremgangsmåde til at bestemme morfologiske parametre og fysiologiske egenskaber af hudvæv, hvilken fremgangsmåde omfatter trinnene at: generere reflektionsmålinger af et hudvævsområde fra reflektionsbilleder opnået for en flerhed af bølgelængder fra flere belysningsvinkler og detektion under anvendelse af en spektralreflektionsmåler bestående af et målehoved med 12 faste lys-sendende diode (LED) lamper og 3 kameraer, hvor hver LED-lampe er anbragt ved en forskellig vinkel relativt til huden, tilvejebringe en bio-optisk model, en strålingsoverføringsmodel, og en ikke-lineær inversionsprocedure; systematisk variere inputværdier af de morfologiske parametre og fysiologiske egenskaber af hudvævet og samtidigt variere inhærente optiske egenskaber af hudvævet, hvor de inhærente optiske egenskaber er forbundet til de morfologiske parametre og de fysiologiske egenskaber af hudvævet af den bio-optiske model, og beregne reflektioner af strålingsoverførselsmodellen for de varierede inhærente optiske egenskaber indtil en overensstemmelse mellem reflektionsmålingerne og reflektionerne beregnet af strålingsoverførselsmodellen når et forudbestemt niveau af nøjagtighed; og opnå de morfologiske parametre og de fysiologiske egenskaber returneret af den ikke-lineære inversionsprocedure.
2. Fremgangsmåden ifølge krav 1, hvor den biooptiske model er baseret på etableret absorptions- og transmissionsspektrer for kendte hudvævschromophorer og relaterer morfologiske parametre og fysiologiske egenskaber af væv til inhærente optiske egenskaber af væv.
3. Fremgangsmåden ifølge krav 1, hvor strålingsoverføringsmodellen anvendes i koblede luft-vævsystemer for at beregne syntetiske reflektionsspektrer for en flerhed af forskellige bølgelængder og en flerhed af forskellige målingskonfigurationer, hver med specificerede retninger af belysning og observation.
4. Fremgangsmåden ifølge krav 1, hvor den ikke-lineære inversionsprocedure er baseret på en optimal estimationsteori for at løse det inverse problem af kvantificering af specificerede morfologiske parametre og fysiologiske egenskaber af hudvæv, de morfologiske parametre og fysiologiske egenskaber af hudvæv eventuelt omfattende, dermalt blodindhold, procentvis blodoxygenering, øvre epidermis-tykkelse, nedre epidermis-tykkelse, procent af øvre melanosom-koncentration, procent af nedre melanosomkoncentration, og procent af keratinkoncentration.
5. Fremgangsmåden ifølge krav 1, hvor fremgangsmåden anvendes til at diskriminere mellem en af: godartede pigmenterede læsioner og malignt melanom; godartetvæv- og basalcellecarcinom; og godartetvæv- og squamous cellecarcinom.
6. Fremgangsmåden ifølge krav 1, hvor fremgangsmåden anvendes til skønhedspleje, retsmedicin, eller til at monitorere virkninger af forskellige slags behandlinger.
DK09722309.3T 2008-03-18 2009-03-18 Optisk fremgangsmåde til at bestemme morfologiske parametre og fysiologiske egenskaber af hudvæv DK2255173T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3750308P 2008-03-18 2008-03-18
PCT/US2009/037511 WO2009117485A2 (en) 2008-03-18 2009-03-18 Optical method for determining morphological parameters and physiological properties of tissue

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DK2255173T3 true DK2255173T3 (da) 2018-03-26

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DK09722309.3T DK2255173T3 (da) 2008-03-18 2009-03-18 Optisk fremgangsmåde til at bestemme morfologiske parametre og fysiologiske egenskaber af hudvæv

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US (1) US9823189B2 (da)
EP (2) EP2992818B1 (da)
JP (2) JP5580809B2 (da)
AU (1) AU2009225617B2 (da)
CA (1) CA2718906C (da)
DK (2) DK2992818T3 (da)
NO (1) NO2255173T3 (da)
NZ (1) NZ588545A (da)
WO (1) WO2009117485A2 (da)
ZA (1) ZA201006943B (da)

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Publication number Publication date
EP2992818B1 (en) 2019-09-04
CA2718906A1 (en) 2009-09-24
EP2255173A4 (en) 2012-10-17
JP2011517416A (ja) 2011-06-09
EP2255173A2 (en) 2010-12-01
WO2009117485A3 (en) 2010-03-04
US9823189B2 (en) 2017-11-21
NZ588545A (en) 2013-05-31
ZA201006943B (en) 2014-03-26
DK2992818T3 (da) 2019-10-21
AU2009225617A1 (en) 2009-09-24
EP2255173B1 (en) 2018-01-24
NO2255173T3 (da) 2018-06-23
JP2014144355A (ja) 2014-08-14
JP5580809B2 (ja) 2014-08-27
CA2718906C (en) 2018-09-11
JP6035268B2 (ja) 2016-11-30
EP2992818A1 (en) 2016-03-09
AU2009225617B2 (en) 2014-07-10
US20110054298A1 (en) 2011-03-03
WO2009117485A2 (en) 2009-09-24

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