DK214585A - PROCEDURE FOR THE PREPARATION OF IMIDAZORIFAMYCINES - Google Patents

PROCEDURE FOR THE PREPARATION OF IMIDAZORIFAMYCINES Download PDF

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Publication number
DK214585A
DK214585A DK214585A DK214585A DK214585A DK 214585 A DK214585 A DK 214585A DK 214585 A DK214585 A DK 214585A DK 214585 A DK214585 A DK 214585A DK 214585 A DK214585 A DK 214585A
Authority
DK
Denmark
Prior art keywords
alkyl
formula
image
carbamoyl
mono
Prior art date
Application number
DK214585A
Other languages
Danish (da)
Other versions
DK160829B (en
DK160829C (en
DK214585D0 (en
Inventor
Vincenzo Cannata
Silvano Piani
Gian Franco Tamagnone
Manuela Campana
Giovanni Da Roit
Original Assignee
Alfa Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT03464/84A external-priority patent/IT1199375B/en
Priority claimed from IT03465/84A external-priority patent/IT1199376B/en
Application filed by Alfa Farmaceutici Spa filed Critical Alfa Farmaceutici Spa
Publication of DK214585D0 publication Critical patent/DK214585D0/en
Publication of DK214585A publication Critical patent/DK214585A/en
Publication of DK160829B publication Critical patent/DK160829B/en
Application granted granted Critical
Publication of DK160829C publication Critical patent/DK160829C/en

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Abstract

Process for preparing imidazorifamycins of the formula <IMAGE> in which R is hydrogen or acetyl, and R1 and R2, independently of each other, are hydrogen, (C1-4)-alkyl, benzyloxy, mono- or di-(C1-3)-alkylamino-(C1-4)-alkyl, (C1-3)-alkoxy-(C1-4)-alkyl, hydroxy-(C1-4)-alkyl, cyano, halogen, nitro, mercapto, (C1-4)-alkylthio, phenylthio, carbamoyl, mono- or di-(C1-4)-alkyl-carbamoyl, or R1 and R2, together with two consecutive carbon atoms in the pyridine nucleus, form a benzene ring which is optionally substituted by one or two methyl or ethyl groups. The process comprises reacting rifamycin S of the formula <IMAGE> with a 2-aminopyridine of the formula <IMAGE> in which R1 and R2 have the abovementioned meanings.
DK214585A 1984-05-15 1985-05-14 PROCEDURE FOR PREPARING PYRIDO-IMIDAZORIFAMYCINES DK160829C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT346584 1984-05-15
IT346484 1984-05-15
IT03464/84A IT1199375B (en) 1984-05-15 1984-05-15 PROCESS FOR THE PREPARATION OF IMIDAZO RIFAMICINE
IT03465/84A IT1199376B (en) 1984-05-15 1984-05-15 IMIDAZO-RIFAMICINE PREPARATION PROCESS

Publications (4)

Publication Number Publication Date
DK214585D0 DK214585D0 (en) 1985-05-14
DK214585A true DK214585A (en) 1985-11-16
DK160829B DK160829B (en) 1991-04-22
DK160829C DK160829C (en) 1991-10-07

Family

ID=26325399

Family Applications (1)

Application Number Title Priority Date Filing Date
DK214585A DK160829C (en) 1984-05-15 1985-05-14 PROCEDURE FOR PREPARING PYRIDO-IMIDAZORIFAMYCINES

Country Status (9)

Country Link
AR (1) AR242795A1 (en)
AT (1) AT386829B (en)
CA (1) CA1215976A (en)
DK (1) DK160829C (en)
ES (1) ES8603490A1 (en)
FI (1) FI83874C (en)
GR (1) GR851146B (en)
NO (1) NO164030C (en)
PT (1) PT80447B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20032144A1 (en) 2003-11-07 2005-05-08 Alfa Wassermann Spa REFLEXIMINE POLIMORPHIC FORMS, PROCESSES TO OBTAIN THEM AND
US7906542B2 (en) 2004-11-04 2011-03-15 Alfa Wassermann, S.P.A. Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin
US7902206B2 (en) 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
PL1698630T3 (en) 2005-03-03 2014-12-31 Alfasigma Spa New polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations
AU2007298733B2 (en) 2006-09-22 2012-11-08 Cipla Limited Rifaximin
US7709634B2 (en) 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
CA2745980C (en) 2008-12-10 2017-10-31 Cipla Limited Rifaximin complexes
ITBO20120368A1 (en) 2012-07-06 2014-01-07 Alfa Wassermann Spa COMPOSITIONS INCLUDING RIFAXIMINA AND AMINO ACIDS, RIFAXIMINE CRYSTALS DERIVING FROM SUCH COMPOSITIONS AND THEIR USE.
EP2927235B1 (en) 2014-03-31 2017-02-08 Euticals S.P.A. Polymorphic mixture of rifaximin and its use for the preparation of solid formulations
WO2015159275A2 (en) * 2014-04-19 2015-10-22 Granules India Limited An improved process for the preparation of rifamycin derivatives
HUE050054T2 (en) 2014-05-12 2020-11-30 Alfasigma Spa Preparation and use of crystalline form tau of rifaximin solvated with degme

Also Published As

Publication number Publication date
FI851908A0 (en) 1985-05-14
GR851146B (en) 1985-11-25
NO164030C (en) 1990-08-22
FI851908L (en) 1985-11-16
AR242795A1 (en) 1993-05-31
DK160829B (en) 1991-04-22
DK160829C (en) 1991-10-07
FI83874C (en) 1991-09-10
PT80447B (en) 1987-11-11
NO164030B (en) 1990-05-14
ATA145085A (en) 1988-03-15
AT386829B (en) 1988-10-25
PT80447A (en) 1985-06-01
DK214585D0 (en) 1985-05-14
NO851920L (en) 1985-11-18
ES543116A0 (en) 1986-01-01
ES8603490A1 (en) 1986-01-01
CA1215976A (en) 1986-12-30
FI83874B (en) 1991-05-31

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