DK2134353T3 - TWO-PHASE LIPID VESICLE COMPOSITION AND METHOD OF TREATING CERVIC DYSPLASY BY INTRAVAGINAL ADMINISTRATION - Google Patents
TWO-PHASE LIPID VESICLE COMPOSITION AND METHOD OF TREATING CERVIC DYSPLASY BY INTRAVAGINAL ADMINISTRATION Download PDFInfo
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- DK2134353T3 DK2134353T3 DK08733666.5T DK08733666T DK2134353T3 DK 2134353 T3 DK2134353 T3 DK 2134353T3 DK 08733666 T DK08733666 T DK 08733666T DK 2134353 T3 DK2134353 T3 DK 2134353T3
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Applications Claiming Priority (2)
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| US90932407P | 2007-03-30 | 2007-03-30 | |
| PCT/CA2008/000563 WO2008119160A1 (en) | 2007-03-30 | 2008-03-27 | Biphasic lipid-vesicle composition and method for treating cervical dysplasia by intravaginal delivery |
Publications (1)
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| DK2134353T3 true DK2134353T3 (en) | 2017-02-20 |
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| FR3008900B1 (fr) * | 2013-07-25 | 2018-03-30 | Centre Nat Rech Scient | Nanoparticules lipidiques multicompartimentees |
| US10159646B2 (en) * | 2013-08-12 | 2018-12-25 | Altum-Avro Pharma Partnership | Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery |
| US8986732B2 (en) * | 2013-08-12 | 2015-03-24 | Helix Biopharma Corporation | Biphasic lipid-vesicle compositions and methods for treating cervical dysplasia by intravaginal delivery |
| WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| US20150147382A1 (en) * | 2013-09-23 | 2015-05-28 | Exir Nano Sina Company | Topical liposomal compositions for delivering hydrophobic drugs and methods preparing same |
| WO2018213789A1 (en) | 2017-05-18 | 2018-11-22 | Modernatx, Inc. | Modified messenger rna comprising functional rna elements |
| US20180360757A1 (en) * | 2017-05-26 | 2018-12-20 | Altum Pharmaceuticals Inc. | Biphasix cannabinoid delivery |
| EP3714047A2 (en) | 2017-11-22 | 2020-09-30 | ModernaTX, Inc. | Polynucleotides encoding phenylalanine hydroxylase for the treatment of phenylketonuria |
| CA3079428A1 (en) | 2017-11-22 | 2019-05-31 | Modernatx, Inc. | Polynucleotides encoding ornithine transcarbamylase for the treatment of urea cycle disorders |
| US20230009009A1 (en) | 2018-09-13 | 2023-01-12 | Modernatx, Inc. | Polynucleotides encoding glucose-6-phosphatase for the treatment of glycogen storage disease |
| CA3112398A1 (en) | 2018-09-14 | 2020-03-19 | Modernatx, Inc. | Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome |
| BR112022005354A2 (pt) * | 2019-09-23 | 2022-08-23 | Dds Res Inc | Composições de vesícula lipídica com agentes potencializadores de penetração |
| US20240216288A1 (en) | 2021-03-24 | 2024-07-04 | Modernatx, Inc. | Lipid nanoparticles containing polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits and uses thereof |
| AU2022242835A1 (en) | 2021-03-24 | 2023-10-05 | Glo Pharma, Inc. | Peptides and methods for reducing skin pigmentation |
| WO2022204390A1 (en) | 2021-03-24 | 2022-09-29 | Modernatx, Inc. | Lipid nanoparticles containing polynucleotides encoding phenylalanine hydroxylase and uses thereof |
| US20240207374A1 (en) | 2021-03-24 | 2024-06-27 | Modernatx, Inc. | Lipid nanoparticles containing polynucleotides encoding glucose-6-phosphatase and uses thereof |
| US20240376445A1 (en) | 2021-06-22 | 2024-11-14 | Modernatx, Inc. | Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome |
| EP4426263A2 (en) * | 2021-11-04 | 2024-09-11 | GLO Pharma, Inc. | Methods and compositions for cosmetic applications |
| TW202412818A (zh) | 2022-07-26 | 2024-04-01 | 美商現代公司 | 用於暫時控制表現之經工程化多核苷酸 |
| WO2024130158A1 (en) | 2022-12-16 | 2024-06-20 | Modernatx, Inc. | Lipid nanoparticles and polynucleotides encoding extended serum half-life interleukin-22 for the treatment of metabolic disease |
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| US5358708A (en) * | 1993-01-29 | 1994-10-25 | Schering Corporation | Stabilization of protein formulations |
| EP0711148B1 (en) | 1993-07-28 | 2000-08-30 | Pharmaderm Laboratories Ltd. | Biphasic multilamellar lipid vesicles |
| IN184589B (enrdf_load_stackoverflow) * | 1996-10-16 | 2000-09-09 | Alza Corp | |
| US5993852A (en) * | 1997-08-29 | 1999-11-30 | Pharmaderm Laboratories Ltd. | Biphasic lipid vesicle composition for transdermal administration of an immunogen |
| US6656499B1 (en) * | 1999-11-12 | 2003-12-02 | Pharmaderm Laboratories, Ltd. | Composition for transdermal and dermal administration of interferon-α |
| TWI272948B (en) | 2003-05-01 | 2007-02-11 | Ares Trading Sa | HSA-free stabilized interferon liquid formulations |
| EP1576952A1 (en) * | 2004-03-18 | 2005-09-21 | OctoPlus Technologies B.V. | Hydrogel microspheres with improved release profile |
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| MX2009010405A (es) | 2010-02-03 |
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| PL2134353T3 (pl) | 2017-06-30 |
| PT2134353T (pt) | 2017-02-15 |
| US8945529B2 (en) | 2015-02-03 |
| US20100196453A1 (en) | 2010-08-05 |
| TW200846030A (en) | 2008-12-01 |
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| US20130216610A1 (en) | 2013-08-22 |
| EP2134353B1 (en) | 2016-11-16 |
| HRP20170250T1 (hr) | 2017-04-07 |
| AU2008234364B2 (en) | 2013-10-17 |
| AU2008234364A1 (en) | 2008-10-09 |
| US20130224283A1 (en) | 2013-08-29 |
| EP2134353A4 (en) | 2013-08-07 |
| TWI440477B (zh) | 2014-06-11 |
| CY1118794T1 (el) | 2017-07-12 |
| CA2681565C (en) | 2016-10-25 |
| LT2134353T (lt) | 2017-03-27 |
| HUE033256T2 (hu) | 2017-11-28 |
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