DK2086932T3 - Substituerede aryl-indol forbindelser og deres kynurenin/kynuramin-lignende metabolitter som terapeutiske midler - Google Patents
Substituerede aryl-indol forbindelser og deres kynurenin/kynuramin-lignende metabolitter som terapeutiske midlerInfo
- Publication number
- DK2086932T3 DK2086932T3 DK07859335.7T DK07859335T DK2086932T3 DK 2086932 T3 DK2086932 T3 DK 2086932T3 DK 07859335 T DK07859335 T DK 07859335T DK 2086932 T3 DK2086932 T3 DK 2086932T3
- Authority
- DK
- Denmark
- Prior art keywords
- kynuramine
- kynurenine
- metabolites
- substituted aryl
- therapeutic agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84864206P | 2006-10-03 | 2006-10-03 | |
PCT/IB2007/004306 WO2008041140A2 (en) | 2006-10-03 | 2007-10-03 | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2086932T3 true DK2086932T3 (da) | 2014-11-10 |
Family
ID=39271279
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07859335.7T DK2086932T3 (da) | 2006-10-03 | 2007-10-03 | Substituerede aryl-indol forbindelser og deres kynurenin/kynuramin-lignende metabolitter som terapeutiske midler |
Country Status (14)
Country | Link |
---|---|
US (3) | US7622495B2 (da) |
EP (2) | EP2086932B1 (da) |
JP (1) | JP5426386B2 (da) |
CN (1) | CN101528689B (da) |
AR (1) | AR063128A1 (da) |
CL (1) | CL2007002858A1 (da) |
DK (1) | DK2086932T3 (da) |
ES (1) | ES2523026T3 (da) |
HK (1) | HK1133886A1 (da) |
PL (1) | PL2086932T3 (da) |
PT (1) | PT2086932E (da) |
SI (1) | SI2086932T1 (da) |
TW (1) | TWI407954B (da) |
WO (1) | WO2008041140A2 (da) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8642598B2 (en) | 2006-10-21 | 2014-02-04 | Abbvie Inc. | Heterocyclic compounds and their use as glycogen synthase kinase 3 inhibitors |
WO2009147681A1 (en) | 2008-06-06 | 2009-12-10 | Pharma Two B Ltd. | Pharmaceutical compositions for treatment of parkinson's disease |
CA2810954A1 (en) | 2010-09-27 | 2012-04-05 | Abbott Gmbh & Co. Kg | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
ES2650744T3 (es) | 2010-12-14 | 2018-01-22 | Electrophoretics Limited | Inhibidores de la caseína quinasa 1 delta (CK1delta) |
US9090592B2 (en) | 2010-12-30 | 2015-07-28 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
WO2013152039A1 (en) * | 2012-04-02 | 2013-10-10 | The Trustees Of Columbia University In The City Of New York | Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders |
JP6340409B2 (ja) * | 2013-03-14 | 2018-06-06 | ヴィスタゲン セラピューティクス、インコーポレイテッド | キラルキヌレニン化合物の合成方法 |
WO2016027757A1 (ja) * | 2014-08-18 | 2016-02-25 | 国立大学法人大阪大学 | 新規2-アミノベンゾイル誘導体 |
EA033632B1 (ru) * | 2014-12-19 | 2019-11-12 | Glaxosmithkline Ip Dev Ltd | 3-(6-АЛКОКСИ-5-ХЛОРБЕНЗО[d]ИЗОКСАЗОЛ-3-ИЛ)ПРОПИОНОВАЯ КИСЛОТА, ПОЛЕЗНАЯ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНУРЕНИНМОНООКСИГЕНАЗЫ |
AR108586A1 (es) * | 2016-06-10 | 2018-09-05 | Lilly Co Eli | Compuestos de 2,3-dihidro-1h-indol |
CN106362155A (zh) * | 2016-10-08 | 2017-02-01 | 无锡汉强医药科技有限公司 | Gsk3抑制剂在制备治疗尼曼匹克病c型疾病中的应用 |
CN106995828B (zh) * | 2017-02-04 | 2020-10-09 | 中国科学院成都生物研究所 | 利用喜树悬浮细胞生产n1-乙酰犬尿胺的方法 |
WO2018216705A1 (ja) * | 2017-05-23 | 2018-11-29 | 国立大学法人京都大学 | 神経変性疾患の予防及び/又は治療剤 |
US11712425B2 (en) | 2018-03-14 | 2023-08-01 | Albert Einstein College Of Medicine | Immunoregulatory role of 3-OH-kynurenamine and uses thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2870162A (en) * | 1954-04-28 | 1959-01-20 | Upjohn Co | Production of certain tryptamines and compounds produced in the process |
JPS5336455B2 (da) | 1973-02-03 | 1978-10-03 | ||
IL79264A0 (en) | 1986-06-27 | 1986-09-30 | Univ Ramot | Tryptamine derivatives,pharmaceutical compositions containing them and their use in an assay for melatonin receptors |
AUPO274596A0 (en) | 1996-10-04 | 1996-10-31 | Armstrong, Stuart Maxwell | Method for the treatment of neurological or neuropsychiatric disorders |
US6410584B1 (en) * | 1998-01-14 | 2002-06-25 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells with indole derivatives |
JP2000007626A (ja) | 1998-06-25 | 2000-01-11 | Taisho Pharmaceut Co Ltd | N−置換ニトロアニリン誘導体 |
IL138825A (en) | 2000-10-03 | 2006-06-11 | Neurim Pharma 1991 | Pharmaceutical preparations containing tryptamine derivatives and similar compounds, and such new compounds |
ES2238616T3 (es) * | 2001-09-27 | 2005-09-01 | F. Hoffmann-La Roche Ag | Derivados de indol como inhibidores de cox ii. |
US6933316B2 (en) * | 2001-12-13 | 2005-08-23 | National Health Research Institutes | Indole compounds |
IL156669A0 (en) | 2003-06-26 | 2004-01-04 | Neurim Pharma 1991 | 2-aminobenzoyl derivatives |
NZ553646A (en) | 2004-09-22 | 2010-07-30 | Janssen Pharmaceutica Nv | Inhibitors of the interaction between MDM2 and p53 |
-
2007
- 2007-10-01 US US11/865,437 patent/US7622495B2/en not_active Expired - Fee Related
- 2007-10-03 TW TW096137075A patent/TWI407954B/zh not_active IP Right Cessation
- 2007-10-03 EP EP07859335.7A patent/EP2086932B1/en not_active Not-in-force
- 2007-10-03 DK DK07859335.7T patent/DK2086932T3/da active
- 2007-10-03 EP EP13179983.5A patent/EP2664615A1/en not_active Withdrawn
- 2007-10-03 CL CL200702858A patent/CL2007002858A1/es unknown
- 2007-10-03 AR ARP070104396A patent/AR063128A1/es unknown
- 2007-10-03 ES ES07859335.7T patent/ES2523026T3/es active Active
- 2007-10-03 WO PCT/IB2007/004306 patent/WO2008041140A2/en active Application Filing
- 2007-10-03 CN CN2007800370844A patent/CN101528689B/zh not_active Expired - Fee Related
- 2007-10-03 PL PL07859335T patent/PL2086932T3/pl unknown
- 2007-10-03 JP JP2009530968A patent/JP5426386B2/ja not_active Expired - Fee Related
- 2007-10-03 SI SI200731548T patent/SI2086932T1/sl unknown
- 2007-10-03 PT PT78593357T patent/PT2086932E/pt unknown
-
2009
- 2009-11-03 US US12/611,373 patent/US8003702B2/en not_active Expired - Fee Related
-
2010
- 2010-02-12 HK HK10101675.8A patent/HK1133886A1/xx not_active IP Right Cessation
-
2011
- 2011-08-03 US US13/197,462 patent/US8236858B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7622495B2 (en) | 2009-11-24 |
US20110319494A1 (en) | 2011-12-29 |
ES2523026T3 (es) | 2014-11-20 |
TWI407954B (zh) | 2013-09-11 |
EP2086932A2 (en) | 2009-08-12 |
WO2008041140A8 (en) | 2009-07-09 |
PL2086932T3 (pl) | 2015-02-27 |
WO2008041140A3 (en) | 2008-08-14 |
AR063128A1 (es) | 2008-12-30 |
TW200824684A (en) | 2008-06-16 |
CN101528689B (zh) | 2013-04-24 |
JP2010505816A (ja) | 2010-02-25 |
CL2007002858A1 (es) | 2008-05-16 |
EP2086932B1 (en) | 2014-08-27 |
HK1133886A1 (en) | 2010-04-09 |
US20080132559A1 (en) | 2008-06-05 |
PT2086932E (pt) | 2014-11-10 |
EP2664615A1 (en) | 2013-11-20 |
US20100048663A1 (en) | 2010-02-25 |
SI2086932T1 (sl) | 2014-12-31 |
US8003702B2 (en) | 2011-08-23 |
CN101528689A (zh) | 2009-09-09 |
JP5426386B2 (ja) | 2014-02-26 |
WO2008041140A2 (en) | 2008-04-10 |
US8236858B2 (en) | 2012-08-07 |
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