DK201885A - MONOCLONAL ANTIBODY, ITS MANUFACTURING AND USE - Google Patents

MONOCLONAL ANTIBODY, ITS MANUFACTURING AND USE Download PDF

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Publication number
DK201885A
DK201885A DK201885A DK201885A DK201885A DK 201885 A DK201885 A DK 201885A DK 201885 A DK201885 A DK 201885A DK 201885 A DK201885 A DK 201885A DK 201885 A DK201885 A DK 201885A
Authority
DK
Denmark
Prior art keywords
molecular
reducing conditions
manufacturing
antigens
monoclonal antibody
Prior art date
Application number
DK201885A
Other languages
Danish (da)
Other versions
DK201885D0 (en
DK169507B1 (en
Inventor
Klaus Bosslet
Hans-Harald Sedlacek
Original Assignee
Behringwerke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke Ag filed Critical Behringwerke Ag
Publication of DK201885D0 publication Critical patent/DK201885D0/en
Publication of DK201885A publication Critical patent/DK201885A/en
Application granted granted Critical
Publication of DK169507B1 publication Critical patent/DK169507B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

New antigens (AG 1-4) with at least one common epitope, and monoclonal antibodies recognising these antigens, are claimed. AG1 is a protein antigen with a molecular wt. of 72,000 +- 3000 under reducing and non-reducing conditions. AG2 is a glycoprotein antigen with a molecular wt. of more than 200,000 under non-reducing conditions, and is serologically not identical to F VIIIR:AG. AG3 is a complex of three glycoprotein antigens with molecular wts. of 180,000 +- 10,000, 95,000 +- 10,000 and 55,000 +- 10,000 under non-reducing conditions. AG 4 is a glycoprotein antigen with a molecular wt. of more than 200,000 under non-reducing conditions, and is not identical to EMA.
DK201885A 1984-05-07 1985-05-06 Monoclonal Antibodies, Recognized Epitopes, Methods for Preparation of the Antibodies and Their Use in an In Vitro Diagnostic, as Carriers for a Pharmaceutically Active Substance and for the Preparation of a Therapeutic DK169507B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843416774 DE3416774A1 (en) 1984-05-07 1984-05-07 MONOCLONAL ANTIBODIES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
DE3416774 1984-05-07

Publications (3)

Publication Number Publication Date
DK201885D0 DK201885D0 (en) 1985-05-06
DK201885A true DK201885A (en) 1985-11-08
DK169507B1 DK169507B1 (en) 1994-11-14

Family

ID=6235105

Family Applications (1)

Application Number Title Priority Date Filing Date
DK201885A DK169507B1 (en) 1984-05-07 1985-05-06 Monoclonal Antibodies, Recognized Epitopes, Methods for Preparation of the Antibodies and Their Use in an In Vitro Diagnostic, as Carriers for a Pharmaceutically Active Substance and for the Preparation of a Therapeutic

Country Status (7)

Country Link
EP (2) EP0516190B1 (en)
JP (1) JPH07108918B2 (en)
AT (2) ATE221122T1 (en)
AU (1) AU594305B2 (en)
CA (1) CA1277613C (en)
DE (3) DE3416774A1 (en)
DK (1) DK169507B1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984002983A1 (en) * 1983-01-21 1984-08-02 Frederick James Primus Specific cea-family antigens, antibodies specific thereto and their methods of use
DE3629640A1 (en) * 1986-08-30 1988-03-03 Behringwerke Ag USE OF MONOCLONAL ANTIBODIES FOR THE TREATMENT OF TUMORS
DE3531301A1 (en) * 1985-09-02 1987-03-05 Behringwerke Ag MONOCLONAL ANTIBODIES AGAINST TUMOR ASSOCIATED GLYCOPROTEINS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
DE3432714A1 (en) * 1984-09-06 1986-04-24 Behringwerke Ag, 3550 Marburg TUMOR THERAPEUTICS AND METHOD FOR THE PRODUCTION THEREOF
EP0180413B1 (en) * 1984-10-26 1991-10-02 Wakunaga Seiyaku Kabushiki Kaisha Anti-human cancer monoclonal antibody
AU601379B2 (en) * 1985-11-07 1990-09-13 Trustees Of Columbia University In The City Of New York, The Antigen indicative of human breast cancer and assays based thereon
DE3909799A1 (en) 1989-03-24 1990-09-27 Behringwerke Ag MONOCLONAL ANTIBODIES (MAK) AGAINST TUMOR ASSOCIATED ANTIGENS, THEIR PRODUCTION AND USE
DK2748201T3 (en) 2011-08-23 2018-02-12 Roche Glycart Ag BISPECIFIC T-CELL ACTIVATING ANTIGIN BINDING MOLECULES
EP2961773B1 (en) 2013-02-26 2019-03-20 Roche Glycart AG Bispecific t cell activating antigen binding molecules
CN104936985A (en) 2013-02-26 2015-09-23 罗切格利卡特公司 Bispecific T cell activating antigen binding molecules

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4349528A (en) * 1979-11-21 1982-09-14 The Wistar Institute Monocolonal hybridoma antibody specific for high molecular weight carcinoembryonic antigen
JPH0811075B2 (en) * 1982-06-30 1996-02-07 雄治 松岡 Monoclonal anti-CEA antibody
WO1984002983A1 (en) * 1983-01-21 1984-08-02 Frederick James Primus Specific cea-family antigens, antibodies specific thereto and their methods of use
DE3329184A1 (en) * 1983-08-12 1985-02-21 Behringwerke Ag, 3550 Marburg MONOCLONAL ANTIBODIES WITH SPECIFICITY FOR MEMBRANE-ASSOCIATED ANTIGENS
US4753894A (en) * 1984-02-08 1988-06-28 Cetus Corporation Monoclonal anti-human breast cancer antibodies
EP0160446B1 (en) * 1984-05-01 1992-06-17 Ciba Corning Diagnostics Corp. Breast tumor-associated antigen and monoclonal antibodies specific thereto

Also Published As

Publication number Publication date
EP0160897A2 (en) 1985-11-13
JPS60252499A (en) 1985-12-13
CA1277613C (en) 1990-12-11
DE3588240D1 (en) 2002-08-29
ATE221122T1 (en) 2002-08-15
EP0160897A3 (en) 1987-09-23
DK201885D0 (en) 1985-05-06
DE3416774A1 (en) 1985-11-14
AU4201385A (en) 1985-11-14
EP0516190A3 (en) 1992-12-16
EP0516190B1 (en) 2002-07-24
ATE89605T1 (en) 1993-06-15
DK169507B1 (en) 1994-11-14
JPH07108918B2 (en) 1995-11-22
EP0160897B1 (en) 1993-05-19
AU594305B2 (en) 1990-03-08
EP0516190A2 (en) 1992-12-02
DE3587346D1 (en) 1993-06-24

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed