AU4201385A - Monoclonal antibodies, a process for their preparation and their use - Google Patents

Monoclonal antibodies, a process for their preparation and their use

Info

Publication number
AU4201385A
AU4201385A AU42013/85A AU4201385A AU4201385A AU 4201385 A AU4201385 A AU 4201385A AU 42013/85 A AU42013/85 A AU 42013/85A AU 4201385 A AU4201385 A AU 4201385A AU 4201385 A AU4201385 A AU 4201385A
Authority
AU
Australia
Prior art keywords
molecular
reducing conditions
monoclonal antibodies
antigens
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU42013/85A
Other versions
AU594305B2 (en
Inventor
Klaus Bosslet
Hans-Harald Sedlacek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of AU4201385A publication Critical patent/AU4201385A/en
Application granted granted Critical
Publication of AU594305B2 publication Critical patent/AU594305B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

New antigens (AG 1-4) with at least one common epitope, and monoclonal antibodies recognising these antigens, are claimed. AG1 is a protein antigen with a molecular wt. of 72,000 +- 3000 under reducing and non-reducing conditions. AG2 is a glycoprotein antigen with a molecular wt. of more than 200,000 under non-reducing conditions, and is serologically not identical to F VIIIR:AG. AG3 is a complex of three glycoprotein antigens with molecular wts. of 180,000 +- 10,000, 95,000 +- 10,000 and 55,000 +- 10,000 under non-reducing conditions. AG 4 is a glycoprotein antigen with a molecular wt. of more than 200,000 under non-reducing conditions, and is not identical to EMA.
AU42013/85A 1984-05-07 1985-05-06 Monoclonal antibodies, a process for their preparation and their use Ceased AU594305B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843416774 DE3416774A1 (en) 1984-05-07 1984-05-07 MONOCLONAL ANTIBODIES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
DE3416774 1984-05-07

Publications (2)

Publication Number Publication Date
AU4201385A true AU4201385A (en) 1985-11-14
AU594305B2 AU594305B2 (en) 1990-03-08

Family

ID=6235105

Family Applications (1)

Application Number Title Priority Date Filing Date
AU42013/85A Ceased AU594305B2 (en) 1984-05-07 1985-05-06 Monoclonal antibodies, a process for their preparation and their use

Country Status (7)

Country Link
EP (2) EP0516190B1 (en)
JP (1) JPH07108918B2 (en)
AT (2) ATE89605T1 (en)
AU (1) AU594305B2 (en)
CA (1) CA1277613C (en)
DE (3) DE3416774A1 (en)
DK (1) DK169507B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU582731B2 (en) * 1983-01-21 1989-04-13 Milton David Goldenberg Specific cea-family antigens, antibodies specific thereto and their methods of use

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531301A1 (en) * 1985-09-02 1987-03-05 Behringwerke Ag MONOCLONAL ANTIBODIES AGAINST TUMOR ASSOCIATED GLYCOPROTEINS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
DE3432714A1 (en) * 1984-09-06 1986-04-24 Behringwerke Ag, 3550 Marburg TUMOR THERAPEUTICS AND METHOD FOR THE PRODUCTION THEREOF
DE3629640A1 (en) * 1986-08-30 1988-03-03 Behringwerke Ag USE OF MONOCLONAL ANTIBODIES FOR THE TREATMENT OF TUMORS
EP0180413B1 (en) * 1984-10-26 1991-10-02 Wakunaga Seiyaku Kabushiki Kaisha Anti-human cancer monoclonal antibody
AU601379B2 (en) * 1985-11-07 1990-09-13 Trustees Of Columbia University In The City Of New York, The Antigen indicative of human breast cancer and assays based thereon
DE3909799A1 (en) 1989-03-24 1990-09-27 Behringwerke Ag MONOCLONAL ANTIBODIES (MAK) AGAINST TUMOR ASSOCIATED ANTIGENS, THEIR PRODUCTION AND USE
LT2748201T (en) 2011-08-23 2018-02-26 Roche Glycart Ag Bispecific t cell activating antigen binding molecules
EP2961773B1 (en) 2013-02-26 2019-03-20 Roche Glycart AG Bispecific t cell activating antigen binding molecules
RU2015140917A (en) 2013-02-26 2017-04-03 Роше Гликарт Аг BSPECIFIC ANTI-BINDING MOLECULES ACTIVATING T-CELLS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4349528A (en) * 1979-11-21 1982-09-14 The Wistar Institute Monocolonal hybridoma antibody specific for high molecular weight carcinoembryonic antigen
JPH0811075B2 (en) * 1982-06-30 1996-02-07 雄治 松岡 Monoclonal anti-CEA antibody
EP0131627B1 (en) * 1983-01-21 1992-05-20 PRIMUS, Frederick James Specific cea-family antigens, antibodies specific thereto and their methods of use
DE3329184A1 (en) * 1983-08-12 1985-02-21 Behringwerke Ag, 3550 Marburg MONOCLONAL ANTIBODIES WITH SPECIFICITY FOR MEMBRANE-ASSOCIATED ANTIGENS
US4753894A (en) * 1984-02-08 1988-06-28 Cetus Corporation Monoclonal anti-human breast cancer antibodies
DE3586216T2 (en) * 1984-05-01 1992-12-10 Ciba Corning Diagnostics Corp BREAST TUMOR ASSOCIATED ANTIQUE AND MONOCLONAL ANTIBODIES THEREFOR.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU582731B2 (en) * 1983-01-21 1989-04-13 Milton David Goldenberg Specific cea-family antigens, antibodies specific thereto and their methods of use

Also Published As

Publication number Publication date
EP0160897A2 (en) 1985-11-13
ATE221122T1 (en) 2002-08-15
EP0516190B1 (en) 2002-07-24
AU594305B2 (en) 1990-03-08
EP0516190A3 (en) 1992-12-16
EP0160897A3 (en) 1987-09-23
EP0516190A2 (en) 1992-12-02
ATE89605T1 (en) 1993-06-15
DK169507B1 (en) 1994-11-14
JPS60252499A (en) 1985-12-13
DK201885A (en) 1985-11-08
DE3587346D1 (en) 1993-06-24
JPH07108918B2 (en) 1995-11-22
DE3588240D1 (en) 2002-08-29
CA1277613C (en) 1990-12-11
EP0160897B1 (en) 1993-05-19
DK201885D0 (en) 1985-05-06
DE3416774A1 (en) 1985-11-14

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired