DK190179A - Analogifremgangsmaade til fremstilling af neuroleptisk aktive xanthen-og thioxanthenderivater - Google Patents

Analogifremgangsmaade til fremstilling af neuroleptisk aktive xanthen-og thioxanthenderivater

Info

Publication number
DK190179A
DK190179A DK190179A DK190179A DK190179A DK 190179 A DK190179 A DK 190179A DK 190179 A DK190179 A DK 190179A DK 190179 A DK190179 A DK 190179A DK 190179 A DK190179 A DK 190179A
Authority
DK
Denmark
Prior art keywords
group
groups
effects
formula
carbon atoms
Prior art date
Application number
DK190179A
Other languages
Danish (da)
English (en)
Inventor
N Larsen
K P Boegesoe
P B Hansen
J L M Buus
A J Bigler
Original Assignee
Kefalas As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kefalas As filed Critical Kefalas As
Publication of DK190179A publication Critical patent/DK190179A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • C07D335/14—Thioxanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D335/18—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymerisation Methods In General (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK190179A 1978-05-12 1979-05-09 Analogifremgangsmaade til fremstilling af neuroleptisk aktive xanthen-og thioxanthenderivater DK190179A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1931078 1978-05-12

Publications (1)

Publication Number Publication Date
DK190179A true DK190179A (da) 1979-11-13

Family

ID=10127259

Family Applications (1)

Application Number Title Priority Date Filing Date
DK190179A DK190179A (da) 1978-05-12 1979-05-09 Analogifremgangsmaade til fremstilling af neuroleptisk aktive xanthen-og thioxanthenderivater

Country Status (14)

Country Link
US (3) US4285956A (fr)
EP (1) EP0005607B1 (fr)
JP (1) JPS54154772A (fr)
AT (1) ATE5141T1 (fr)
AU (1) AU522926B2 (fr)
CA (1) CA1127648A (fr)
DE (1) DE2966344D1 (fr)
DK (1) DK190179A (fr)
ES (1) ES480468A1 (fr)
FI (1) FI791503A (fr)
IE (1) IE48261B1 (fr)
NO (1) NO150837C (fr)
NZ (1) NZ190373A (fr)
ZA (1) ZA792250B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4356184A (en) * 1980-06-04 1982-10-26 G. D. Searle & Co. Anti-allergic or antihypertensive 1-piperidinylmethyl benzenamines
US4501749A (en) * 1983-10-31 1985-02-26 Merck & Co., Inc. Peripherally selective dopamine antagonists in the treatment of ocular hypertension
US4777177A (en) * 1984-10-19 1988-10-11 Ciba-Geigy Corporation Pesticidal thioxanthen-9-ylidenepiperidines
US5250681A (en) * 1988-06-02 1993-10-05 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same
US5393890A (en) * 1988-06-02 1995-02-28 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same
CA2004211A1 (fr) * 1988-11-30 1990-05-31 Masataka Syoji Derives de piperidine et hypotenseurs les contenant
US7060711B2 (en) * 2001-10-25 2006-06-13 Biofrontera Bioscience Gmbh Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
EP1306376A1 (fr) * 2001-10-25 2003-05-02 Biofrontera Pharmaceuticals AG Dérives de 4-(thio- or selenoxanthene-9-ylidene)-piperidine ou acridine et leur application comme antagonistes selectives de 5-HT2B
BRPI0411998A (pt) * 2003-06-27 2006-09-05 Janssen Pharmaceutica Nv moduladores delta-opióides tricìclicos
WO2007030089A1 (fr) * 2004-08-05 2007-03-15 Janssen Pharmaceutica N.V. Modulateurs d’opioïdes delta tricycliques
BRPI0519201A2 (pt) 2004-12-22 2008-12-30 Janssen Pharmaceutica Nv moduladores de delta-opiàide tricÍclico
US7439239B2 (en) * 2004-12-22 2008-10-21 Janssen Pharmaceutica N.V. Tricyclic δ- opioid modulators
WO2006069275A1 (fr) * 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. Modulateurs des recepteurs opioides delta tricycliques
CN101128460A (zh) * 2005-01-06 2008-02-20 詹森药业有限公司 三环的δ-阿片样物质调节剂
WO2006138528A2 (fr) 2005-06-16 2006-12-28 Janssen Pharmaceutica N.V Modulateurs d'opioides tricycliques

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470188A (en) * 1967-01-05 1969-09-30 Smithkline Corp 9-cycloalkyl-lower alkyl-piperidylidene derivatives of xanthenes and thioxanthenes
US3974285A (en) * 1974-04-10 1976-08-10 Merck & Co., Inc. 10,11-Furo-derivatives of cyproheptadine
US4086350A (en) * 1974-11-06 1978-04-25 Smithkline Corporation Pharmaceutical compositions and method of producing anti-psychotic activity without extrapyramidal symptoms
US4031222A (en) * 1975-12-22 1977-06-21 Merck & Co., Inc. Trifluoromethylthio (and sulfonyl) derivatives of cyproheptadine analogs
US4073912A (en) * 1976-10-12 1978-02-14 Smithkline Corporation Piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins and antipsychotic use thereof

Also Published As

Publication number Publication date
NO150837B (no) 1984-09-17
NO150837C (no) 1985-01-09
NO791592L (no) 1979-11-13
IE791105L (en) 1979-11-12
DE2966344D1 (en) 1983-12-01
FI791503A (fi) 1979-11-13
US4309429A (en) 1982-01-05
AU522926B2 (en) 1982-07-01
JPS54154772A (en) 1979-12-06
ES480468A1 (es) 1980-07-01
IE48261B1 (en) 1984-11-14
CA1127648A (fr) 1982-07-13
NZ190373A (en) 1981-12-15
AU4694179A (en) 1979-11-15
ATE5141T1 (de) 1983-11-15
US4275209A (en) 1981-06-23
ZA792250B (en) 1980-08-27
EP0005607B1 (fr) 1983-10-26
EP0005607A1 (fr) 1979-11-28
US4285956A (en) 1981-08-25

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