DK1893210T3 - Selektiv apoptotisk induktion i cancerceller, herunder aktivering af procaspase-3 - Google Patents

Selektiv apoptotisk induktion i cancerceller, herunder aktivering af procaspase-3 Download PDF

Info

Publication number
DK1893210T3
DK1893210T3 DK06771588.8T DK06771588T DK1893210T3 DK 1893210 T3 DK1893210 T3 DK 1893210T3 DK 06771588 T DK06771588 T DK 06771588T DK 1893210 T3 DK1893210 T3 DK 1893210T3
Authority
DK
Denmark
Prior art keywords
procaspase
activation
cancer cells
apoptotic induction
selective apoptotic
Prior art date
Application number
DK06771588.8T
Other languages
Danish (da)
English (en)
Inventor
Paul J Hergenrother
Karson S Putt
Grace W Chen
Jennifer M Pearson
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Application granted granted Critical
Publication of DK1893210T3 publication Critical patent/DK1893210T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96466Cysteine endopeptidases (3.4.22)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2510/00Detection of programmed cell death, i.e. apoptosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
DK06771588.8T 2005-05-26 2006-05-26 Selektiv apoptotisk induktion i cancerceller, herunder aktivering af procaspase-3 DK1893210T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68480705P 2005-05-26 2005-05-26
US74387806P 2006-03-28 2006-03-28
US11/420,425 US20070049602A1 (en) 2005-05-26 2006-05-25 Selective Apoptotic Induction in Cancer Cells Including Activation of Procaspase-3
PCT/US2006/020910 WO2006128173A2 (en) 2005-05-26 2006-05-26 Selective apoptotic induction in cancer cells including activation of procaspase-3

Publications (1)

Publication Number Publication Date
DK1893210T3 true DK1893210T3 (da) 2020-01-13

Family

ID=37452994

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06771588.8T DK1893210T3 (da) 2005-05-26 2006-05-26 Selektiv apoptotisk induktion i cancerceller, herunder aktivering af procaspase-3

Country Status (10)

Country Link
US (1) US20070049602A1 (de)
EP (3) EP2659884A3 (de)
JP (2) JP5513741B2 (de)
AU (1) AU2006251978A1 (de)
CA (1) CA2610366A1 (de)
DK (1) DK1893210T3 (de)
ES (1) ES2763156T3 (de)
IL (1) IL187603A0 (de)
MX (1) MX2007014843A (de)
WO (1) WO2006128173A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070049602A1 (en) * 2005-05-26 2007-03-01 The Board Of Trustees Of The University Of Illinois Selective Apoptotic Induction in Cancer Cells Including Activation of Procaspase-3
WO2008134474A2 (en) * 2007-04-27 2008-11-06 The Board Of Trustees Of The University Of Illinois Compositions and methods including cell death inducers and procaspase activation
EP2393794B1 (de) 2009-02-09 2017-03-22 The Board of Trustees of the University of Illionis Entwicklung, synthese und bewertung von procaspaseaktivierenden verbindungen als personalisierte antikrebsmittel
WO2010102513A1 (zh) * 2009-03-11 2010-09-16 深圳市湘雅生物医药研究院 高哌嗪乙酰肼类衍生物及其制备方法和用途
CN101805338B (zh) * 2010-04-06 2014-10-15 沈阳药科大学 噁二唑基哌嗪衍生物及其用途
US8916705B2 (en) * 2011-10-14 2014-12-23 The Board of Trustees of The University of Illilnois Procaspase-activating compounds and compositions
AU2013225682B2 (en) * 2012-03-02 2016-04-14 The Board Of Trustees Of The University Of Illinois Potent anticancer activity via dual compound activation
EP3290035B1 (de) * 2012-03-06 2019-05-15 The Board of Trustees of the University of Illinois Procaspase kombinationstherapie zur behandlung von krebs
CN104507479B (zh) * 2012-03-06 2017-08-18 伊利诺伊大学评议会 通过联合治疗的半胱天冬酶‑3酶原激活
EP2880020B1 (de) * 2012-08-03 2018-11-28 The Board of Trustees of the University of Illionis Enzymaktivierende verbindungen und zusammensetzungen
CN105218399B (zh) 2014-05-30 2018-02-09 中国人民解放军军事医学科学院毒物药物研究所 一种取代乙酰肼类衍生物、其制备方法及用途
ES2906763T3 (es) 2015-06-05 2022-04-20 Univ Illinois Terapia combinada de PAC-1
JP6538976B2 (ja) * 2015-07-23 2019-07-03 ワン,チミン 化合物pac−1またはその塩及びそれらを含有する医薬組成物
US10561667B2 (en) 2015-07-24 2020-02-18 Shenzhen Zhenxing Medical Technology Co., Ltd. Orbit azine-fumarate, hydrate, crystal form and preparation method therefor
CN105085421B (zh) * 2015-07-24 2017-12-26 深圳市湘雅生物医药研究院 奥比特嗪‑富马酸盐、水合物、晶型及其制备方法
CN111491927A (zh) * 2017-11-17 2020-08-04 伊利诺伊大学董事会 通过降解双mek信号传导的癌症疗法
JP2022504184A (ja) 2018-10-05 2022-01-13 ザ ボード オブ トラスティーズ オブ ザ ユニバーシテイ オブ イリノイ ブドウ膜黒色腫の治療のための併用療法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4068666B2 (ja) * 1997-05-22 2008-03-26 ザ バーナム インスティチュート カスパーゼ活性のアポトーシスインヒビター(iap)タンパク質調節を変える薬剤についてのスクリーニングアッセイ
US6403765B1 (en) 1998-06-16 2002-06-11 Thomas Jefferson University Truncated Apaf-1 and methods of use thereof
AU5205499A (en) 1998-07-27 2000-02-21 Pharmacia & Upjohn Company Method for autoactivation of procaspase 8
US6110691A (en) 2000-01-06 2000-08-29 Board Of Regents, The University Of Texas System Activators of caspases
US6608026B1 (en) 2000-08-23 2003-08-19 Board Of Regents, The University Of Texas System Apoptotic compounds
AU2002241508A1 (en) 2000-11-20 2002-06-24 Lawrence C. Fritz Membrane derived caspase-3, compositions comprising the same and methods of use therefor
WO2002069995A2 (en) * 2001-02-16 2002-09-12 Medical College Of Georgia Research Institute, Inc. Use of trail and antiprogestins for treating cancer
KR100439425B1 (ko) * 2001-03-22 2004-07-05 (주)바이오케어 잔토리졸을 포함하는 조성물 및 그 용도
US6878743B2 (en) 2001-09-18 2005-04-12 Sunesis Pharmaceuticals, Inc. Small molecule inhibitors of caspases
WO2004053144A2 (en) * 2002-12-10 2004-06-24 Ottawa Health Research Institute Modulation of stem cell differentiation by modulation of caspase-3 activity
WO2004066958A2 (en) 2003-01-30 2004-08-12 The Trustees Of Princeton University Caspase-9:bir3 domain of xiap complexes and methods of use
US20070049602A1 (en) * 2005-05-26 2007-03-01 The Board Of Trustees Of The University Of Illinois Selective Apoptotic Induction in Cancer Cells Including Activation of Procaspase-3

Also Published As

Publication number Publication date
JP5513741B2 (ja) 2014-06-04
MX2007014843A (es) 2008-02-14
JP2008545718A (ja) 2008-12-18
EP1893210A2 (de) 2008-03-05
WO2006128173A2 (en) 2006-11-30
EP1893210A4 (de) 2010-09-01
US20070049602A1 (en) 2007-03-01
EP1893210B1 (de) 2019-10-02
CA2610366A1 (en) 2006-11-30
JP5907852B2 (ja) 2016-04-26
EP2634581A1 (de) 2013-09-04
IL187603A0 (en) 2008-03-20
EP2659884A3 (de) 2014-10-01
ES2763156T3 (es) 2020-05-27
JP2013100285A (ja) 2013-05-23
EP2659884A2 (de) 2013-11-06
AU2006251978A1 (en) 2006-11-30
WO2006128173A3 (en) 2007-05-24

Similar Documents

Publication Publication Date Title
DK1893210T3 (da) Selektiv apoptotisk induktion i cancerceller, herunder aktivering af procaspase-3
DK3514565T3 (da) Tilvejebringelse af forbedret positionslokalisering i trådløs kommunikation
DE602005022897D1 (de) Piperidinylamino-thienoä2,3-dü-pyrimidinverbindungen
DOP2006000278A (es) Glicosilación en la región variable
DE602005026205D1 (de) Rasiersystem
DE502005007723D1 (de) 18-methyl-19-nor-17-pregn-4-en-21,17-carbolactone,
FR2872704B1 (fr) Pluritherapie contre le cancer
DE602005004015D1 (de) Zerkleinerer
FI20055175A0 (fi) Radioyhteysmenettely CDMA-pohjaisessa viestintäjärjestelmässä
FI20045182A0 (fi) Tiedonsiirto UMTS järjestelmässä
FI20045190A0 (fi) Energiantuotantojärjestely
ITMI20050051A1 (it) Fotodiodio organico di poli-9,9-diottil-fluorene
SE0400384L (sv) Spårfräs
FI20050916A0 (fi) Järjestely lastuavassa työkalussa
DK1720557T3 (da) Hurtig-opløselig, smagsmaskeret tablet
DE112005002004A5 (de) Messer
FR2876232B3 (fr) Convertisseur-thermo-electrique solaire
NO20052022L (no) MultiEnergiFanger
DE602006007259D1 (de) Schneidevorrichtung
EE00608U1 (et) Dokumendisahtel
FI20045499A0 (fi) Järjestely oskillointilaitteessa
FI20050834A0 (fi) Säädettävä pankkokiinnitys
ES1059189Y (es) Bolsillo.
SE0400769D0 (sv) Stereoenheten, KTS Super Power
BR8300904Y1 (pt) disposição introduzida em destocador.