DK188985A - Fremgangsmaade til fremstilling af i 4-stilling substituerede oxaphosphorinderivater - Google Patents
Fremgangsmaade til fremstilling af i 4-stilling substituerede oxaphosphorinderivater Download PDFInfo
- Publication number
- DK188985A DK188985A DK188985A DK188985A DK188985A DK 188985 A DK188985 A DK 188985A DK 188985 A DK188985 A DK 188985A DK 188985 A DK188985 A DK 188985A DK 188985 A DK188985 A DK 188985A
- Authority
- DK
- Denmark
- Prior art keywords
- group
- oxaphosphorin
- derivatives
- procedure
- preparation
- Prior art date
Links
- OMDCSPXITNMPHV-UHFFFAOYSA-N 2h-oxaphosphinine Chemical class O1PC=CC=C1 OMDCSPXITNMPHV-UHFFFAOYSA-N 0.000 title 1
- 150000001768 cations Chemical class 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- -1 cyclohexylammonium cation Chemical class 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 229940126062 Compound A Drugs 0.000 description 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-O guanidinium Chemical compound NC(N)=[NH2+] ZRALSGWEFCBTJO-UHFFFAOYSA-O 0.000 description 1
- 229910052736 halogen Chemical group 0.000 description 1
- 150000002367 halogens Chemical group 0.000 description 1
- 150000002431 hydrogen Chemical group 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-O morpholinium Chemical compound [H+].C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-O 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3415726 | 1984-04-27 | ||
| DE19843415726 DE3415726A1 (de) | 1984-04-27 | 1984-04-27 | Verfahren zur herstellung von in 4-stellung substituierten oxazaphosphorin-derivaten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK188985D0 DK188985D0 (da) | 1985-04-26 |
| DK188985A true DK188985A (da) | 1985-10-28 |
Family
ID=6234515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK188985A DK188985A (da) | 1984-04-27 | 1985-04-26 | Fremgangsmaade til fremstilling af i 4-stilling substituerede oxaphosphorinderivater |
Country Status (9)
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3220432A1 (de) * | 1981-03-24 | 1983-12-01 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Oxazaphosphorin-4-thio-alkansulfonsaeure, ihre neutralen salze, verfahren zur herstellung derselben und diese enthaltenden pharmazeutischen praeparate |
| DE3220672A1 (de) * | 1981-03-24 | 1983-12-08 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Cis-oxazaphosphorin-4-thio-alkansulfonsaeuren, ihre neutralen salze, verfahren zur herstellung derselben und diese enthaltenden pharmazeutischen praeparate |
| DE3111428A1 (de) * | 1981-03-24 | 1982-10-07 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
| EP0083439B1 (de) * | 1981-12-31 | 1989-07-26 | ASTA Pharma AG | 4-Sulfido-oxazaphosphorine und deren Verwendung bei der Krebsbekämpfung und zur Immunsuppression |
-
1984
- 1984-04-27 DE DE19843415726 patent/DE3415726A1/de not_active Withdrawn
-
1985
- 1985-04-24 GR GR850994A patent/GR850994B/el unknown
- 1985-04-25 DD DD27556385A patent/DD232496A5/de unknown
- 1985-04-26 DK DK188985A patent/DK188985A/da not_active Application Discontinuation
- 1985-04-26 HU HU162385A patent/HUT40676A/hu unknown
- 1985-04-26 FI FI851656A patent/FI851656L/fi not_active Application Discontinuation
- 1985-04-26 ES ES542606A patent/ES8607331A1/es not_active Expired
- 1985-04-26 AT AT125685A patent/AT385037B/de not_active IP Right Cessation
- 1985-04-26 PT PT8035685A patent/PT80356B/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES542606A0 (es) | 1986-05-16 |
| FI851656A0 (fi) | 1985-04-26 |
| DD232496A5 (de) | 1986-01-29 |
| PT80356A (de) | 1985-05-01 |
| DK188985D0 (da) | 1985-04-26 |
| DE3415726A1 (de) | 1985-10-31 |
| ATA125685A (de) | 1987-07-15 |
| AT385037B (de) | 1988-02-10 |
| HUT40676A (en) | 1987-01-28 |
| PT80356B (de) | 1987-03-16 |
| ES8607331A1 (es) | 1986-05-16 |
| FI851656L (fi) | 1985-10-28 |
| GR850994B (US07860544-20101228-C00003.png) | 1985-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |