DK187090A - PROCEDURE FOR IMMOBILIZATION OF A POLYPEPTIDE IN A POLYMER AND A HUMAN PREPARED THEREOF - Google Patents

PROCEDURE FOR IMMOBILIZATION OF A POLYPEPTIDE IN A POLYMER AND A HUMAN PREPARED THEREOF Download PDF

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Publication number
DK187090A
DK187090A DK187090A DK187090A DK187090A DK 187090 A DK187090 A DK 187090A DK 187090 A DK187090 A DK 187090A DK 187090 A DK187090 A DK 187090A DK 187090 A DK187090 A DK 187090A
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DK
Denmark
Prior art keywords
pct
anode
electrode
immobilization
sec
Prior art date
Application number
DK187090A
Other languages
Danish (da)
Other versions
DK187090D0 (en
Inventor
Henrik Ege
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of DK187090A publication Critical patent/DK187090A/en
Publication of DK187090D0 publication Critical patent/DK187090D0/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C12Q1/003—Functionalisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/817—Enzyme or microbe electrode

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)

Abstract

PCT No. PCT/DK89/00019 Sec. 371 Date Sep. 5, 1990 Sec. 102(e) Date Sep. 5, 1990 PCT Filed Feb. 3, 1989 PCT Pub. No. WO89/07139 PCT Pub. Date Aug. 10, 1989.The present invention relates generally to the immobilization or incorporation of polypeptides, especially enzymes or other bioactive polypeptides into polymeric matrixes, especially polyurethane, membranes produced by said polymers, and the utilization of such membranes in biosensors. A preferred type of biosensor is the needle sensor designed for in vivo monitoring of glucose which comprises a core platinum anode (2) coated with an insulating lacquer (3), the anode (2) is situated inside a stainless steel reference cathode (4) which is insulated from the anode (2) by a layer of epoxy resin (5) At one end, of the tip, the electrode (1) has a detection surface (6) which is in an acute angle to the general direction of the electrode (1). At the other end, the base, the electrode (2) is provided with terminals (7) and (8) for the anode (2) and cathode (4), respectively. The terminals (7) and (8) are soldered to leads (9) and (10), respectively, which are connected to instrumentation used when performing measurements.
DK187090A 1988-02-05 1990-08-06 PROCEDURE FOR IMMOBILIZATION OF A POLYPEPTIDE IN A POLYMER AND A HUMAN PREPARED THEREOF DK187090D0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK061488A DK61488D0 (en) 1988-02-05 1988-02-05 COURSE OF ACTION
PCT/DK1989/000019 WO1989007139A1 (en) 1988-02-05 1989-02-03 A method for immobilizing a polypeptide in a polymer and a membrane produced thereby

Publications (2)

Publication Number Publication Date
DK187090A true DK187090A (en) 1990-08-06
DK187090D0 DK187090D0 (en) 1990-08-06

Family

ID=8095570

Family Applications (2)

Application Number Title Priority Date Filing Date
DK061488A DK61488D0 (en) 1988-02-05 1988-02-05 COURSE OF ACTION
DK187090A DK187090D0 (en) 1988-02-05 1990-08-06 PROCEDURE FOR IMMOBILIZATION OF A POLYPEPTIDE IN A POLYMER AND A HUMAN PREPARED THEREOF

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK061488A DK61488D0 (en) 1988-02-05 1988-02-05 COURSE OF ACTION

Country Status (9)

Country Link
US (1) US5223124A (en)
EP (1) EP0397784B1 (en)
JP (1) JP2790348B2 (en)
AT (1) ATE95562T1 (en)
AU (1) AU613157B2 (en)
CA (1) CA1319633C (en)
DE (1) DE68909777T2 (en)
DK (2) DK61488D0 (en)
WO (1) WO1989007139A1 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8909613D0 (en) * 1989-04-27 1989-06-14 Pickup John C Glucose-sensing electrode
DE4027728A1 (en) * 1990-08-31 1992-03-05 Bayer Ag IMMOBILIZATION OF ORGANIC MACROMOLECULES OR BIOPOLYMERS IN A POLYMER MEMBRANE
US5354449A (en) * 1991-01-10 1994-10-11 Band David M pH electrode
JPH06507709A (en) * 1991-06-04 1994-09-01 ファイスンズ　ピーエルシー Analysis equipment
AT401653B (en) * 1994-10-05 1996-11-25 Avl Verbrennungskraft Messtech METHOD FOR IMMOBILIZING BIOLOGICAL COMPONENTS IN A POLYMER MATRIX, AND BIOSENSORS USING SUCH IMMOBILIZERS
US5611900A (en) * 1995-07-20 1997-03-18 Michigan State University Microbiosensor used in-situ
FR2754707B1 (en) * 1996-10-22 1999-01-08 Philippe Korsec HEATING ACUPUNCTURE NEEDLE
US6379691B1 (en) 1998-09-29 2002-04-30 Medtronic/Ave, Inc. Uses for medical devices having a lubricious, nitric oxide-releasing coating
US6299980B1 (en) 1998-09-29 2001-10-09 Medtronic Ave, Inc. One step lubricious coating
US6833260B1 (en) 1999-10-08 2004-12-21 Protein Scientific, Inc. Lactose hydrolysis
US6592730B1 (en) * 2000-02-07 2003-07-15 Steris Inc. Durable carbon electrode
US6793632B2 (en) * 2001-06-12 2004-09-21 Lifescan, Inc. Percutaneous biological fluid constituent sampling and measurement devices and methods
US6501976B1 (en) * 2001-06-12 2002-12-31 Lifescan, Inc. Percutaneous biological fluid sampling and analyte measurement devices and methods
US7335400B2 (en) * 2001-07-24 2008-02-26 University Of Pittsburgh Irreversible immobilization of enzymes into polyurethane coatings
CA2500452A1 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Switchable microneedle arrays and systems and methods relating to same
US7101472B2 (en) * 2002-03-13 2006-09-05 The Charles Stark Draper Laboratory, Inc. Microfluidic ion-selective electrode sensor system
US7407570B2 (en) * 2002-03-13 2008-08-05 The Charles Stark Draper Laboratory, Inc. Disposable, self-administered electrolyte test
EP1604609A4 (en) * 2003-02-17 2008-09-03 Toyo Prec Parts Mfg Co Ltd Linear device
WO2005051183A1 (en) * 2003-11-25 2005-06-09 Novo Nordisk A/S A needle sensor and a mechanism for inserting the needle sensor through the skin
US7283866B2 (en) * 2004-05-18 2007-10-16 Hatch Ltd Needle having multiple electrodes
WO2006127023A2 (en) * 2004-08-24 2006-11-30 University Of South Florida Epoxy enhanced polymer membrane to increase durability of biosensors
WO2007022485A2 (en) * 2005-08-19 2007-02-22 Becton, Dickinson And Company Sterilization of biosensors
US8702932B2 (en) 2007-08-30 2014-04-22 Pepex Biomedical, Inc. Electrochemical sensor and method for manufacturing
WO2009051901A2 (en) 2007-08-30 2009-04-23 Pepex Biomedical, Llc Electrochemical sensor and method for manufacturing
US9439585B2 (en) 2008-02-04 2016-09-13 Ascensia Diabetes Care Holdings Ag Semiconductor based analyte sensors and methods
WO2010033741A1 (en) * 2008-09-19 2010-03-25 Bayer Healthcare Llc Analyte sensors, systems, testing apparatus and manufacturing methods
CN102171557B (en) 2008-09-19 2016-10-19 安晟信医疗科技控股公司 There is electrochemical appliance and the manufacture method thereof of the electro-chemical activity of enhancing
US8951377B2 (en) 2008-11-14 2015-02-10 Pepex Biomedical, Inc. Manufacturing electrochemical sensor module
WO2010056878A2 (en) 2008-11-14 2010-05-20 Pepex Biomedical, Llc Electrochemical sensor module
US9504162B2 (en) 2011-05-20 2016-11-22 Pepex Biomedical, Inc. Manufacturing electrochemical sensor modules
CN102551674B (en) * 2012-01-30 2015-04-22 东南大学 Needle with biological detecting function and application of needle
BR112015012958B1 (en) 2012-12-03 2022-03-15 Pepex Biomedical, Inc Sensor module to detect an analyte in a blood sample
WO2015187959A1 (en) 2014-06-04 2015-12-10 Pepex Biomedical, Inc. Electrochemical sensors and methods for making electrochemical sensors using advanced printing technology

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237229A (en) * 1975-06-10 1980-12-02 W. R. Grace & Co. Immobilization of biological material with polyurethane polymers
US4094744A (en) * 1976-11-18 1978-06-13 W. R. Grace & Co. Water-dispersible protein/polyurethane reaction product
US4407957A (en) * 1981-03-13 1983-10-04 Damon Corporation Reversible microencapsulation of a core material
DE3617875C2 (en) * 1985-06-28 1993-10-14 Hitachi Plant Eng & Constr Co Process for immobilizing microorganisms
GB8522834D0 (en) * 1985-09-16 1985-10-23 Ici Plc Sensor
DE3540333A1 (en) * 1985-11-14 1987-05-21 Bayer Ag METHOD FOR IMMOBILIZING BIOLOGICAL MATERIAL, PARTICLE-SHAPED COAGULATES CONTAINING AN IMMOBILIZED BIOLOGICAL MATERIAL AND THEIR USE AS A CATALYST
US4871716A (en) * 1986-02-04 1989-10-03 University Of Florida Magnetically responsive, hydrophilic microspheres for incorporation of therapeutic substances and methods of preparation thereof
DE3705687A1 (en) * 1987-02-23 1988-09-01 Boehringer Mannheim Gmbh POLYURETHANE MODIFIED ENZYMS

Also Published As

Publication number Publication date
DE68909777T2 (en) 1994-03-10
CA1319633C (en) 1993-06-29
JP2790348B2 (en) 1998-08-27
ATE95562T1 (en) 1993-10-15
EP0397784B1 (en) 1993-10-06
EP0397784A1 (en) 1990-11-22
DE68909777D1 (en) 1993-11-11
DK61488D0 (en) 1988-02-05
US5223124A (en) 1993-06-29
AU613157B2 (en) 1991-07-25
JPH03503480A (en) 1991-08-08
DK187090D0 (en) 1990-08-06
WO1989007139A1 (en) 1989-08-10
AU3064689A (en) 1989-08-25

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