DK1830833T3 - Kombination af en glycintransportør (GLyT1) inhibitor og et antipsykotikum til behandling af symptomer på schizofreni samt dens fremstilling og anvendelse deraf - Google Patents
Kombination af en glycintransportør (GLyT1) inhibitor og et antipsykotikum til behandling af symptomer på schizofreni samt dens fremstilling og anvendelse derafInfo
- Publication number
- DK1830833T3 DK1830833T3 DK05849954.2T DK05849954T DK1830833T3 DK 1830833 T3 DK1830833 T3 DK 1830833T3 DK 05849954 T DK05849954 T DK 05849954T DK 1830833 T3 DK1830833 T3 DK 1830833T3
- Authority
- DK
- Denmark
- Prior art keywords
- antipsychotic
- schizophrenia
- symptoms
- glyt1
- treatment
- Prior art date
Links
- 230000000561 anti-psychotic effect Effects 0.000 title abstract 4
- 201000000980 schizophrenia Diseases 0.000 title abstract 3
- 208000024891 symptom Diseases 0.000 title abstract 3
- 238000011282 treatment Methods 0.000 title abstract 3
- 102000010726 Glycine Plasma Membrane Transport Proteins Human genes 0.000 title 2
- 108010063380 Glycine Plasma Membrane Transport Proteins Proteins 0.000 title 2
- 239000003112 inhibitor Substances 0.000 title 1
- 229940123454 Glucose transporter 1 inhibitor Drugs 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63657504P | 2004-12-16 | 2004-12-16 | |
PCT/US2005/045749 WO2006066121A2 (en) | 2004-12-16 | 2005-12-15 | Combination of a glycine transporter (glyt1) inhibitor and an antipsychotic for the treatment of symptoms of schizophrenia as well as its preparation and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1830833T3 true DK1830833T3 (da) | 2010-05-17 |
Family
ID=36168474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05849954.2T DK1830833T3 (da) | 2004-12-16 | 2005-12-15 | Kombination af en glycintransportør (GLyT1) inhibitor og et antipsykotikum til behandling af symptomer på schizofreni samt dens fremstilling og anvendelse deraf |
Country Status (12)
Country | Link |
---|---|
US (1) | US20060154919A1 (da) |
EP (1) | EP1830833B1 (da) |
AT (1) | ATE456366T1 (da) |
CA (1) | CA2590287A1 (da) |
CY (1) | CY1110617T1 (da) |
DE (1) | DE602005019203D1 (da) |
DK (1) | DK1830833T3 (da) |
ES (1) | ES2338346T3 (da) |
PL (1) | PL1830833T3 (da) |
PT (1) | PT1830833E (da) |
SI (1) | SI1830833T1 (da) |
WO (1) | WO2006066121A2 (da) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008032056A2 (en) * | 2006-09-16 | 2008-03-20 | Genophrenix Limited | Dopamine receptor interacting proteins as markers for disease |
US20090253918A1 (en) * | 2006-10-02 | 2009-10-08 | Janssen Pharmaceuticals, N.V. | Novel intermediate for glyt1 inhibitor |
KR20180102052A (ko) * | 2015-10-16 | 2018-09-14 | 노오쓰웨스턴 유니버시티 | 조현병, 양극성 장애, 인지 손상 및 주요 우울 장애의 치료를 위한 비전형적 항정신병약과 nmda 조절제의 약제학적 병용 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5187171A (en) * | 1989-01-09 | 1993-02-16 | G. D. Searle & Co. | Use of a glycine b partial agonist as an antipsychotic |
DK0871440T3 (da) * | 1995-12-07 | 2006-07-10 | Daniel C Javitt | Behandling af negative og kognitive symptomer på skizofreni med glycinoptagelsesantagonister |
ATE369848T1 (de) * | 1998-04-14 | 2007-09-15 | Gen Hospital Corp | Verwendung von d-serine oder d-alanine zur behandlung von schizophrenie |
US6476208B1 (en) * | 1998-10-13 | 2002-11-05 | Genset | Schizophrenia associated genes, proteins and biallelic markers |
US6426364B1 (en) * | 1999-11-01 | 2002-07-30 | Nps Allelix Corp. | Diaryl-enynes |
US6335681B1 (en) * | 2001-02-08 | 2002-01-01 | Teofilo Ontiveros | Cruise control alert |
WO2002066456A2 (en) * | 2001-02-16 | 2002-08-29 | Allelix Neuroscience, Inc. | Thiophene substituted amine derivatives as glyt-1 inhibitors |
GB0314479D0 (en) * | 2003-06-20 | 2003-07-23 | Glaxo Group Ltd | Compounds |
AU2004289290A1 (en) * | 2003-11-12 | 2005-05-26 | Merck & Co., Inc. | 4-phenyl piperdine sulfonyl glycine transporter inhibitors |
WO2005058885A2 (en) * | 2003-12-18 | 2005-06-30 | Glaxo Group Limited | Piperidine derivatives and their use as glycine transporter inhibitors |
WO2005058317A1 (en) * | 2003-12-18 | 2005-06-30 | Glaxo Group Limited | Glycine transporter-1 inhibirors |
WO2006000222A2 (en) * | 2004-06-24 | 2006-01-05 | H. Lundbeck A/S | The combination of an antipsychotic and a glycine transporter type i inhibitor for the treatment of schizophrenia |
-
2005
- 2005-12-15 DK DK05849954.2T patent/DK1830833T3/da active
- 2005-12-15 WO PCT/US2005/045749 patent/WO2006066121A2/en active Application Filing
- 2005-12-15 CA CA002590287A patent/CA2590287A1/en not_active Abandoned
- 2005-12-15 US US11/304,175 patent/US20060154919A1/en not_active Abandoned
- 2005-12-15 EP EP05849954A patent/EP1830833B1/en active Active
- 2005-12-15 PL PL05849954T patent/PL1830833T3/pl unknown
- 2005-12-15 AT AT05849954T patent/ATE456366T1/de active
- 2005-12-15 DE DE602005019203T patent/DE602005019203D1/de active Active
- 2005-12-15 SI SI200530955T patent/SI1830833T1/sl unknown
- 2005-12-15 ES ES05849954T patent/ES2338346T3/es active Active
- 2005-12-15 PT PT05849954T patent/PT1830833E/pt unknown
-
2010
- 2010-04-14 CY CY20101100335T patent/CY1110617T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PL1830833T3 (pl) | 2010-06-30 |
CY1110617T1 (el) | 2015-04-29 |
WO2006066121A2 (en) | 2006-06-22 |
SI1830833T1 (sl) | 2010-05-31 |
EP1830833A2 (en) | 2007-09-12 |
EP1830833B1 (en) | 2010-01-27 |
DE602005019203D1 (de) | 2010-03-18 |
PT1830833E (pt) | 2010-03-12 |
WO2006066121A3 (en) | 2006-08-10 |
CA2590287A1 (en) | 2006-06-22 |
ES2338346T3 (es) | 2010-05-06 |
ATE456366T1 (de) | 2010-02-15 |
US20060154919A1 (en) | 2006-07-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200800755A1 (ru) | Ikk ингибиторы, предназначенные для лечения эндометриоза | |
NO20052888L (no) | Diamintriazoler anvendelige som inhibitorer av proteinkinaser | |
DK1539166T3 (da) | Farmaceutiske sammensætninger indeholdende dextromethorphan og quinidin til behandling af neurologiske sygdomme | |
ZA200707508B (en) | 2-[isoquinolin-3-carbonyl) amino] -propionic acid derivatives as inhibitors of factors XI and IX for the treatment of thrombosis | |
DE602005022113D1 (de) | Phenyl)methanon-derivate als glycin-transporter 1 (glyt-1) hemmer zur behandlung von neurologischen und neuropsychiatrischen erkrankungen | |
NO20082894L (no) | Metode for behandling av kognitiv dysfunksjon | |
EA200870380A1 (ru) | Аминотетрагидропираны в качестве ингибиторов дипептидилпептидазы-vi для лечения или предупреждения диабета | |
BRPI0517435A (pt) | triazóis úteis como inibidores de proteìna cinase | |
NO20054369L (no) | Anvendelse av en IBAT-inhibitor for behandling og profylakse av forstoppelse | |
DK2463283T3 (da) | Kondenserede heterocykliske phenylamidoforbindelser til forebyggelse og behandling af glucokinase-medierede sygdomme | |
BRPI0514017A (pt) | indazóis úteis no tratamento de doenças cardiovasculares | |
ZA200609021B (en) | Novel use of peptide compounds for treating essential tremor and other tremor syndromes | |
NO20071019L (no) | Quinazolinderivater og deres anvendelse ved behandling av trombocytemi | |
DE60332433D1 (de) | Azolylaminoazine als proteinkinasehemmer | |
DE60332604D1 (de) | Azolylaminoazine als proteinkinasehemmer | |
ATE542823T1 (de) | 4,5-dihydro-ä1,2,4ütriazoloä4,3-füpteridine als plk1-proteinkinasehemmer zur behandlung proliferativer erkrankungen | |
NO20075731L (no) | Inhibitorer av mikrosomalt triglyceridtransferprotein og APO-B-sekresjon | |
MX2008012479A (es) | Tratamiento de enfermedades neurodegenerativas. | |
EA200800766A1 (ru) | Ингибиторы pi3k для лечения эндометриоза | |
NO20071378L (no) | Tiazolo-naftylsyrer. | |
DK1919466T3 (da) | Formuleringer til behandling af lipoprotein-abnormiteter omfattende et statin og et methylnicotinamidderivat | |
NO20063842L (no) | Silinanforbindelser som cysteinproteaseinhibitorer | |
NO20054216L (no) | Anvendelse av dipyridamol i kombinasjon med acetylsalisylsyre og en angiotensin II antagonist for forhindring av slag | |
WO2007140317A3 (en) | Use of inhibitors of cytosolic ph0sph0lipase a2 in the treatment of thrombosis | |
CY1111762T1 (el) | Διενυδρη παμοϊκη ολανζαπiνη |