DK175889B1 - Sårheling og knogleregenerering - Google Patents
Sårheling og knogleregenerering Download PDFInfo
- Publication number
- DK175889B1 DK175889B1 DK198803932A DK393288A DK175889B1 DK 175889 B1 DK175889 B1 DK 175889B1 DK 198803932 A DK198803932 A DK 198803932A DK 393288 A DK393288 A DK 393288A DK 175889 B1 DK175889 B1 DK 175889B1
- Authority
- DK
- Denmark
- Prior art keywords
- pdgf
- igf
- growth factor
- platelet
- purified
- Prior art date
Links
- 230000029663 wound healing Effects 0.000 title claims description 12
- 230000010478 bone regeneration Effects 0.000 title claims description 5
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims abstract description 78
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims abstract description 78
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims abstract description 54
- 239000000203 mixture Substances 0.000 claims abstract description 19
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims description 52
- 238000002360 preparation method Methods 0.000 claims description 14
- 239000003102 growth factor Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 abstract description 13
- 230000035876 healing Effects 0.000 abstract description 8
- 241000124008 Mammalia Species 0.000 abstract description 6
- 102000013275 Somatomedins Human genes 0.000 abstract description 2
- 230000001172 regenerating effect Effects 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 30
- 208000027418 Wounds and injury Diseases 0.000 description 30
- 101710103494 Platelet-derived growth factor subunit B Proteins 0.000 description 27
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 27
- 102100040990 Platelet-derived growth factor subunit B Human genes 0.000 description 24
- 210000002808 connective tissue Anatomy 0.000 description 18
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 15
- 239000011780 sodium chloride Substances 0.000 description 14
- 210000004027 cell Anatomy 0.000 description 13
- 108090000623 proteins and genes Proteins 0.000 description 12
- 239000000710 homodimer Substances 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 238000001574 biopsy Methods 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 108020004414 DNA Proteins 0.000 description 5
- 102100037596 Platelet-derived growth factor subunit A Human genes 0.000 description 5
- 101710103506 Platelet-derived growth factor subunit A Proteins 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 229920001184 polypeptide Polymers 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- 239000012064 sodium phosphate buffer Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 102000008186 Collagen Human genes 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 210000002950 fibroblast Anatomy 0.000 description 4
- 230000008929 regeneration Effects 0.000 description 4
- 238000011069 regeneration method Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 3
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 3
- 239000000908 ammonium hydroxide Substances 0.000 description 3
- 238000000376 autoradiography Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 108091008816 c-sis Proteins 0.000 description 3
- 210000000349 chromosome Anatomy 0.000 description 3
- 210000000981 epithelium Anatomy 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 239000012894 fetal calf serum Substances 0.000 description 3
- 229940126864 fibroblast growth factor Drugs 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 239000000833 heterodimer Substances 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 230000011164 ossification Effects 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 3
- 101800003838 Epidermal growth factor Proteins 0.000 description 2
- 102400001368 Epidermal growth factor Human genes 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 208000004210 Pressure Ulcer Diseases 0.000 description 2
- 241000288906 Primates Species 0.000 description 2
- 108020004511 Recombinant DNA Proteins 0.000 description 2
- 229920005654 Sephadex Polymers 0.000 description 2
- 239000012507 Sephadex™ Substances 0.000 description 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000002491 angiogenic effect Effects 0.000 description 2
- 238000012742 biochemical analysis Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229940116977 epidermal growth factor Drugs 0.000 description 2
- 210000005081 epithelial layer Anatomy 0.000 description 2
- 230000002962 histologic effect Effects 0.000 description 2
- 210000003041 ligament Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000001466 metabolic labeling Methods 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000037390 scarring Effects 0.000 description 2
- 108700021652 sis Genes Proteins 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 2
- 229940104230 thymidine Drugs 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 208000008822 Ankylosis Diseases 0.000 description 1
- 206010065687 Bone loss Diseases 0.000 description 1
- 238000009010 Bradford assay Methods 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010023198 Joint ankylosis Diseases 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 108091008606 PDGF receptors Proteins 0.000 description 1
- 241000282577 Pan troglodytes Species 0.000 description 1
- 102000015731 Peptide Hormones Human genes 0.000 description 1
- 108010038988 Peptide Hormones Proteins 0.000 description 1
- 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 208000010641 Tooth disease Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 238000003277 amino acid sequence analysis Methods 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 210000004618 arterial endothelial cell Anatomy 0.000 description 1
- 238000000211 autoradiogram Methods 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000008366 buffered solution Substances 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000003399 chemotactic effect Effects 0.000 description 1
- 239000000512 collagen gel Substances 0.000 description 1
- 230000037319 collagen production Effects 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 238000005115 demineralization Methods 0.000 description 1
- 230000002328 demineralizing effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 150000002019 disulfides Chemical class 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000008472 epithelial growth Effects 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000002297 mitogenic effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000004498 neuroglial cell Anatomy 0.000 description 1
- 230000002188 osteogenic effect Effects 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 210000004261 periodontium Anatomy 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 210000004623 platelet-rich plasma Anatomy 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93076286A | 1986-11-14 | 1986-11-14 | |
| US93076286 | 1986-11-14 | ||
| PCT/US1987/002975 WO1988003409A1 (fr) | 1986-11-14 | 1987-11-13 | Guerison de plaies et regeneration d'os |
| US8702975 | 1987-11-13 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK393288D0 DK393288D0 (da) | 1988-07-14 |
| DK393288A DK393288A (da) | 1988-09-13 |
| DK175889B1 true DK175889B1 (da) | 2005-05-30 |
Family
ID=25459724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198803932A DK175889B1 (da) | 1986-11-14 | 1988-07-14 | Sårheling og knogleregenerering |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0289584B1 (fr) |
| JP (1) | JPH01500199A (fr) |
| KR (1) | KR960005708B1 (fr) |
| CN (1) | CN1027346C (fr) |
| AT (1) | ATE88899T1 (fr) |
| AU (1) | AU600069B2 (fr) |
| DE (1) | DE3785758T2 (fr) |
| DK (1) | DK175889B1 (fr) |
| IE (1) | IE60517B1 (fr) |
| MX (1) | MX170454B (fr) |
| NO (1) | NO883127L (fr) |
| NZ (1) | NZ222551A (fr) |
| OA (1) | OA09159A (fr) |
| WO (1) | WO1988003409A1 (fr) |
| ZA (1) | ZA878566B (fr) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4849407A (en) * | 1986-08-13 | 1989-07-18 | Zymogenetics, Inc. | Biologically active mosaic proteins |
| US5474982A (en) * | 1986-08-13 | 1995-12-12 | Zymogenetics, Inc. | PDGF analogs and methods of use |
| US4885163A (en) * | 1987-02-24 | 1989-12-05 | Eli Lilly And Company | Topical use of IGF-II for wound healing |
| IL95641A0 (en) * | 1989-09-15 | 1991-06-30 | Curative Tech Inc | Preparation of a platelet releasate product |
| ZA9010332B (en) * | 1989-12-22 | 1991-08-28 | Ciba Geigy | Method of reducing or preventing adverse effect of steroid therapy and compositions therefor |
| WO1991015231A1 (fr) * | 1990-04-10 | 1991-10-17 | Institute Of Molecular Biology, Inc. | Cicatrisation de plaies |
| ES2178633T3 (es) * | 1990-05-30 | 2003-01-01 | Harvard College | Utilizacion concomitante del factor -i de crecimiento similar a insulina (en lo sucesivo "fci-i") y el factor de crecimiento transformante beta (en la sucesivo "fct-beta") para la fabricacion de un medicamento para la regeneracion de huesos en mamiferos. |
| US6054122A (en) | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| US6197325B1 (en) | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| US7208179B1 (en) | 1990-11-27 | 2007-04-24 | The American National Red Cross | Methods for treating disease and forming a supplemented fibrin matrix |
| US6117425A (en) | 1990-11-27 | 2000-09-12 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, method of their production and use |
| WO1993008825A1 (fr) * | 1991-11-04 | 1993-05-13 | Zymogenetics, Inc. | Formulation d'un gel de fcdp |
| FR2691911B1 (fr) * | 1992-06-05 | 1994-11-25 | Delmas Olivier | Dispositif permettant l'obtention d'un surnageant de thrombocytes activés, procédé mettant en Óoeuvre le dispositif et surnageant obtenu. |
| JPH06510065A (ja) * | 1992-06-08 | 1994-11-10 | カイロン コーポレーション | 成長因子ｉｇｆ−ｉおよび／またはｉｇｆ−ｉｉの用法 |
| FR2696095B1 (fr) * | 1992-09-30 | 1994-11-25 | Inoteb | Colle biologique à base de protéines coagulables par la thrombine, enrichie en facteurs plaquettaires, sa préparation et son application. |
| CN1055023C (zh) * | 1993-01-03 | 2000-08-02 | 周至譓 | 伤口护理剂 |
| EP1217067A2 (fr) | 1994-07-12 | 2002-06-26 | Human Genome Sciences, Inc. | Facteur de croissance 2 de tissu conjonctif |
| US7026299B2 (en) | 1994-07-12 | 2006-04-11 | Human Genome Sciences, Inc. | Connective tissue growth factor-2 |
| US5728676A (en) * | 1994-09-08 | 1998-03-17 | Ciba-Geigy Corporation | Use of insulin-like growth factors I and II for inhibition of inflammatory response |
| ES2293137T3 (es) | 1995-10-11 | 2008-03-16 | Novartis Vaccines And Diagnostics, Inc. | Combinacion de pdgf, kgf,igf e igfbp para curacion de heridas. |
| EP1935901A1 (fr) | 1996-12-13 | 2008-06-25 | Novartis Vaccines and Diagnostics, Inc. | Analyse et séparation de protéines PDGF |
| US6663870B2 (en) | 1998-12-07 | 2003-12-16 | Zymogenetics, Inc. | Methods for promoting growth of bone using zvegf3 |
| US6468543B1 (en) | 1999-05-03 | 2002-10-22 | Zymogenetics, Inc. | Methods for promoting growth of bone using ZVEGF4 |
| GB2369572A (en) | 2000-11-29 | 2002-06-05 | Raft Trustees Ltd | Wound treatment composition comprising insulin |
| US7622562B2 (en) | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
| US7241874B2 (en) | 2002-06-26 | 2007-07-10 | Zimmer Ortho Biologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
| US7473678B2 (en) | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| KR20080084808A (ko) | 2005-11-17 | 2008-09-19 | 바이오미메틱 세라퓨틱스, 인크. | ｒｈＰＤＧＦ-ＢＢ 및 생체적합성 매트릭스를 사용하는상악안면골 보강 |
| WO2007092622A2 (fr) | 2006-02-09 | 2007-08-16 | Biomimetic Therapeutics, Inc. | Compositions et méthodes pour le traitement d'os |
| CA2656278C (fr) | 2006-06-30 | 2016-02-09 | Biomimetic Therapeutics, Inc. | Compositions et procedes destines au traitement de lesions de la coiffe des rotateurs |
| US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| US8106008B2 (en) | 2006-11-03 | 2012-01-31 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures |
| JP5864106B2 (ja) | 2008-02-07 | 2016-02-17 | バイオミメティック セラピューティクス， エルエルシー | 仮骨延長のための組成物および方法 |
| AU2009291828C1 (en) | 2008-09-09 | 2016-03-17 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries |
| CA2790403C (fr) | 2010-02-22 | 2019-08-27 | Biomimetic Therapeutics, Inc. | Compositions de facteur de croissance derive des plaquettes et procedes pour le traitement de tendinopathies |
| CN102397534B (zh) * | 2010-09-07 | 2013-10-23 | 中国人民解放军总医院 | 胰岛素在制备促进颌骨组织愈合的药物中的用途 |
| WO2013077641A1 (fr) * | 2011-11-22 | 2013-05-30 | (주)아모레퍼시픽 | Agent d'amélioration de la réparation de la peau contenant des facteurs de croissance |
| CA2962954A1 (fr) | 2014-10-14 | 2016-04-21 | Samuel Lynch | Compositions pour le traitement de plaies |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4479896A (en) * | 1981-12-11 | 1984-10-30 | Antoniades Harry N | Method for extraction localization and direct recovery of platelet derived growth factor |
-
1987
- 1987-11-13 AT AT87907900T patent/ATE88899T1/de not_active IP Right Cessation
- 1987-11-13 EP EP87907900A patent/EP0289584B1/fr not_active Expired - Lifetime
- 1987-11-13 KR KR1019880700829A patent/KR960005708B1/ko not_active IP Right Cessation
- 1987-11-13 JP JP63500179A patent/JPH01500199A/ja active Granted
- 1987-11-13 AU AU83289/87A patent/AU600069B2/en not_active Expired
- 1987-11-13 WO PCT/US1987/002975 patent/WO1988003409A1/fr active IP Right Grant
- 1987-11-13 IE IE307587A patent/IE60517B1/en not_active IP Right Cessation
- 1987-11-13 DE DE8787907900T patent/DE3785758T2/de not_active Expired - Lifetime
- 1987-11-14 CN CN87101250A patent/CN1027346C/zh not_active Expired - Lifetime
- 1987-11-16 ZA ZA878566A patent/ZA878566B/xx unknown
- 1987-11-16 NZ NZ222551A patent/NZ222551A/xx unknown
- 1987-11-16 MX MX009367A patent/MX170454B/es unknown
-
1988
- 1988-07-13 NO NO883127A patent/NO883127L/no unknown
- 1988-07-14 DK DK198803932A patent/DK175889B1/da not_active IP Right Cessation
- 1988-07-14 OA OA59385A patent/OA09159A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK393288D0 (da) | 1988-07-14 |
| DE3785758T2 (de) | 1993-08-05 |
| EP0289584A4 (fr) | 1990-01-08 |
| CN87101250A (zh) | 1988-06-08 |
| OA09159A (en) | 1992-03-31 |
| JPH01500199A (ja) | 1989-01-26 |
| NO883127D0 (no) | 1988-07-13 |
| KR960005708B1 (ko) | 1996-05-01 |
| WO1988003409A1 (fr) | 1988-05-19 |
| AU600069B2 (en) | 1990-08-02 |
| ATE88899T1 (de) | 1993-05-15 |
| EP0289584B1 (fr) | 1993-05-05 |
| IE873075L (en) | 1988-05-14 |
| EP0289584A1 (fr) | 1988-11-09 |
| NZ222551A (en) | 1989-11-28 |
| CN1027346C (zh) | 1995-01-11 |
| JPH0581569B2 (fr) | 1993-11-15 |
| AU8328987A (en) | 1988-06-01 |
| MX170454B (es) | 1993-08-24 |
| DE3785758D1 (de) | 1993-06-09 |
| IE60517B1 (en) | 1994-07-27 |
| ZA878566B (en) | 1989-07-26 |
| DK393288A (da) | 1988-09-13 |
| NO883127L (no) | 1988-09-12 |
| KR890700033A (ko) | 1989-03-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK175889B1 (da) | Sårheling og knogleregenerering | |
| US4861757A (en) | Wound healing and bone regeneration using PDGF and IGF-I | |
| DK175947B1 (da) | Sårheling | |
| US5019559A (en) | Wound healing using PDGF and IGF-II | |
| CA2040410C (fr) | Compositions pour traiter des plaies contenant de l'interleukine 1 et un facteur de croissance | |
| EP0382841B1 (fr) | Cicatrisation de blessures | |
| WO2008096268A2 (fr) | Transfert de noeud de lymphe autologue en combinaison avec une thérapie de facteur croissant vegf-c ou vegf-d pour traiter un second lymphoedème et pour améliorer la chirurgie réparatrice | |
| EP0479799B1 (fr) | Cicatrisation de plaies | |
| CA2082420C (fr) | Composition cicatrisante comprenant du igf-i ou igf-ii purifie et un tgf-.beta. purifie |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |