DK1751313T3 - Identifikation af tumorer - Google Patents

Description

DESCRIPTION

FIELD OF THE INVENTION

[0001] This invention relates to the use of gene expression to dassify human tumors. The classification is performed by use of gene expression profiles, or patterns, of 50 or more expressed sequences that are correlated with tumors arising from certain tissues as well as being correlated with certain tumor types. The invention also provides for the use of 50 or more spedfic gene sequences, the expression of wfnich are correlated with tissue source and tumor type in various cancers. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to determine a cell containing sample as containing tumor cells of a tissue type or from a tissue origin to permit a more accurate identification of the cancer and thus treatment thereof as well as the prognosis of the subject from whom the sample was obtained.

SUMMARY OF THE INVENTION

[0002] This invention relates to the use of gene expression measurements to classify or identify tumors in cell containing samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples. The invention provides the ability to dassify tumors in the real-world conditions faced by hospital and other laboratories which have to conduct testing on clinical FFPE samples. The invention may also be applied to other samples, such as fresh samples, that have undergone none to little or minimal treatment (such as simply storage at a reduced, non-freezing, temperature), and frozen samples. The samples may be of a primary tumor sample or of a tumor that has resulted from a metastasis of another tumor. Alternatively, the sample may be a cytological sample, such as, but not limited to, cells in a blood sample. In some cases of a tumor sample, the tumors may not have undergone dassification by traditional pathology techniques, may have been initially classified but confirmation is desired, or have been classified as a "carcinoma of unknown primary" (CUP) or "tumor of unknown origin" (TUO) or "unknown primary tumor". The need for confirmation is particularly relevant in light of the estimates of 5 to 10% misclassification using standard techniques. Thus the invention may be viewed as providing means for cancer identification, or CID.

[0003] In a first aspect of the invention, there is provided a method of classifying a cell containing sample as containing tumor cells of a tissue type, said method comprising determining the expression levels of 50 or more transcribed sequences from cells in a cell containing sample obtained from a human subject, and classifying the sample as containing, by eliminating one or more tumor types from consideration, tumor cells of an epithelial or non-epithelial tissue type, including a germ cell tumor or a sarcoma, based on the expression levels of said sequences. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other markers of gene expression, may be used to determine a cell containing sample as containing tumor cells of a tissue type or from a tissue origin to permit a more accurate identification of the cancer and thus treatment thereof as well as the prognosis of the subject from whom the sample was obtained.

[0004] In some embodiments, the invention is used to classify among at least 34 or at least 39 tumor types with significant accuracy in a clinical setting. The invention is based in part on the surprising and unexpected discovery that 50 or more expressed sequences in the human genome are capable of classifying among at least 34, or at least 39, tumor types, as well as subsets of those tumor types, in a meaningful manner. Stated differently, the invention is based in part on the discovery that it is not necessary to use supervised learning to identify gene sequences which are expressed in correlation with different tumor types. Thus the invention is based in part on the recognition that any 50 or more expressed sequences, even a random collection of expressed sequences, has the capability to classify, and so may be used to classify, a cell as being a tumor cell of a tissue or tissue origin.

[0005] We also describe the classifying of a cell containing sample as containing a tumor cell of a tissue type or origin by determining the expression levels of 50 or more transcribed sequences and then classifying the cell containing sample as containing a tumor cell of a plurality (two or more) of tumor types. To classify among at least 34 to at least 39 tumor types, and subsets thereof, as few as any 50 expressed sequences may be used to provide classification in a meaningful manner. The invention is also based in part on the observation that the expressed sequences need not be those the expression levels of which are evidently or highly correlated (directly, or indirectly through correlation with another expressed sequence) with any of the tumor types. We also describe the use of the expression levels of genes, the expression levels of which are not strongly correlated with the actual classification of the particular tumor sample, as one of the 50 or more transcribed sequences. All of the genes selected may be such non-correlates, or only a portion of the genes may be non- correlates, typically at least 90%, 85%, 75%, 50% or 25%, as well as portions falling within the ranges created by using any two of the foregoing point examples as endpoints ofa range.

[0006] The invention is practiced by determining the expression levels of gene sequences where the sequences need not have been selected based on a correlation of their expression levels with the tumor types to be classified. Thus as a non-limiting example, the gene sequences need not be selected based on their correlation values with tumor types or a ranking based on the correlation values. Additionally, the invention may be practice with use of gene expression levels which are not necessarily correlated to one or more other gene expression level(s) used for classification. Thus in additional embodiments, the ability for the expression level of one expressed sequence to function in classification is not redundant with (is independent of) the ability of at least one other gene expression level used for classification.

[0007] The invention may be applied to identify the origin of a cancer in a patient in a wide variety of cases including, but not limited to, identification of the origin of a cancer in a clinical setting. In some embodiments, the identification is made by classification of a cell containing sample known to contain cancer cells, but the origin of those cells is unknown. In other embodiments, the identification is made by classification of a cell containing sample as containing one or more cancer cells followed by identification of the origin(s) of those cancer cell(s). In further embodiments, the invention is practiced with a sample from a subject with a previous history of cancer, and identification is made by classification of a cell as either being cancer from a previous origin of cancer or a new origin. Additional embodiments include those where multiple cancers found in the same organ or tissue and the invention is used to determine the origin of each cancer, as well as whether the cancers are of the same origin.

[0008] The invention is also based in part on the discovery that the expression levels of particular gene sequences can be used to classify among tumor types with greater accuracy than the expression levels of a random group of gene sequences. In one embodiment, the invention-provides for the use of expression levels of 50 to 74 expressed sequences of a first set in the human genome to classify among at least 34 or at least 39 tumor types with significant accuracy. The invention thus provides for the identification and use of gene expression patterns (or profiles or "signatures") based on the 50 to 74 expressed sequences as correlated with at least the 34 or 39 tumor types. The invention also provides for the use of 50 to 74 of these expressed sequences to classify among subsets of the 34 or 39 tumor types. Depending on the number of tumor types, accuracies ranging from over 80% to 100% may be achieved.

[0009] We also describe the use of expression levels of 50 to 90 expressed sequences of a second set in the human genome to classify among at least 34 or at least 39 tumor types with significant accuracy. 38 of the sequences in the second set are present in the first set of 74 sequences. The expression levels of the 50 to 90 sequences in the second set may be used in the same manner as described for the first set of 74 sequences. Depending on the number of tumor types, accuracies ranging from about 75% to about 95% may be achieved.

[0010] The invention is also based in part upon the discovery that use of 50 or more expressed sequences to classify among 53 tumor types, which include (but are not limited to) the 34 and 39 types described herein, was limited by the number of available samples of some tumor types. As noted hereinbelow, accuracy is linked to the number of available samples of each tumor type such that the ability to classify additional tumor types is readily achieved by the application of increased numbers of each tumor type. Thus while the invention is exemplified by use in classifying among 34 or 39 tumor types as well as subsets of the 34 or 39, 50 or more expressed sequences can also be used to classify among all tumor types with the inclusion of samples of the additional tumor types. Thus the invention also provides for the classification of a tumor as being a type beyond the 34 or 39 types described herein.

[0011] The invention is based upon the expression levels of the gene sequences in a set of known tumor cells from different tissues and of different tumor types. These gene expression profiles (of gene sequences in the different known tumor cells/types), whether embodied in nucleic acid expression, protein expression, or other expression formats, may be compared to the expression levels of the same sequences in an unknown tumor sample to identify the sample as containing a tumor of a particular type and/or a particular origin or cell type: The invention provides, such as in a clinical setting, the advantages ofa more accurate identification of a cancer and thus the treatment thereof as well as the prognosis, including survival and/or likelihood of cancer recurrence following treatment, of the subject from whom the sample was obtained.

[0012] The invention is further based in part on the discovery that use of 50 or more expressed sequences as described herein as capable of classifying among two or more tumor types necessarily and effectively eliminates one or more tumor types from consideration during classification. This reflects the lack of a need to select genes with expression levels that are highly correlated with all tumor types within the range of the classification system. Stated differently, the invention may be practiced with a plurality of genes the expression levels of which are not highly correlated with any of the individual tumor types or multiple types in the group of tumor types being classified. This is in contrast to other approaches based upon the selection and use of highly correlated genes, which likely do not "rule out" other tumor types as opposed to "rule in" a tumor type based on the positive correlation.

[0013] The classification of a tumor sample as being one of the possible tumor types described herein to the exclusion of other tumor types is of course made based upon a level of confidence as described below. Where the level of confidence is low, or an increase in the level of confidence is preferred, the classification can simply be made at the level of a particular tissue origin or cell type for the tumor in the sample. Alternatively, and where a tumor sample is not readily classified as a single tumor type, the invention permits the classification of the sample as one of a few possible tumor types described herein. This advantageously provides for the ability to reduce the number of possible tissue types, cell types, and tumor types from which to consider for selection and administration of therapy to the patient from whom the sample was obtained.

[0014] We thus describe a non-subjective means for the identification of the tissue source and/or tumor type of one or more cancers of an afflicted subject. Where subjective interpretation may have-been previously used to determine the tissue source and/or tumor type, as well as the prognosis and/or treatment of the cancer based on that determination, the present invention-provides objective gene expression patterns, which may used alone or in combination with subjective criteria to provide a more accurate identification of cancer classification. The invention is particularly advantageously applied to samples of secondary or metastasized tumors, but any cell containing sample (including a primary tumor sample) for which the tissue source and/or tumor type is preferably determined by objective criteria may also be used with the invention. Of course the ultimate determination of class may be made based upon a combination of objective and non-objective (or subjective/partially subjective) criteria.

[0015] The invention includes its use as part of the clinical or medical care of a patient. Thus in addition to using an expression profile of genes as described herein to assay a cell containing sample from a subject afflicted with cancer to determine the tissue source and/or tumor type of the cancer, the profile may also be used as part of a method to determine the prognosis of the cancer in the subject. The classification of the tumor/cancer and/or the prognosis may be used to select or determine or alter the therapeutic treatment for said subject. Thus the classification methods of the invention may be directed toward the treatment of disease, which is diagnosed in whole or in part based upon the classification. Given the diagnosis, administration of an appropriate anti-tumor agent or therapy, or the withholding or alternation of an anti-tumor agent or therapy may be used to treat the cancer.

[0016] Other clinical methods include those involved in the providing of medical care to a patient based on a classification as described herein. In some embodiments, the methods relate to providing diagnostic services based on expression levels of gene sequences, with or without inclusion of an interpretation of levels for classifying cells of a sample. In some embodiments, the method of providing a diagnostic service of the invention is preceded by a determination of a need for the service. In other embodiments, the method includes acts in the monitoring of the performance of the service as well as acts in the request or receipt of reimbursement for the performance of the service.

[0017] The details of one or more embodiments of the invention are set forth in the accompanying drawing and the description below. Other features and advantages of the invention will be apparent from the drawing and detailed description, and from the claims.

DEFINITIONS

[0018] As used herein, a "gene” is a polynucleotide that encodes a discrete product, whether RNAor proteinaceous in nature. It is appreciated that more than one polynucleotide may be capable of encoding a discrete product. The term includes alleles and polymorphisms of a gene that encodes the same product, or a functionally associated (including gain, loss, or modulation of function) analog thereof, based upon chromosomal location and ability to recombine during normal mitosis.

[0019] A "sequence" or "gene sequence" as used herein is a nucleic acid molecule or polynucleotide composed of a discrete order of nucleotide bases. The term includes the ordering of bases that encodes a discrete product (i.e. "coding region"), whether RNA or proteinaceous in nature. It is appreciated that more than one polynucleotide may be capable of encoding a discrete product. It is also appreciated that alleles and polymorphisms of the human gene sequences may exist and may be used in the practice of the invention to identify the expression level(s) of the gene sequences or an allele or polymorphism thereof. Identification of an allele or polymorphism depends in part upon chromosomal location and ability to recombine during mitosis.

[0020] The terms "correlate" or "correlation" or equivalents thereof refer to an association between expression of one or more genes and another event, such as, but not limited to, physiological phenotype or characteristic, such as tumor type.

[0021] A "polynucleotide" is a polymeric form of nucleotides of any length, either ribonucleotides or deoxyribonucleotides. This term refers only to the primary structure of the molecule. Thus, this term includes double- and single-stranded DNA and RNA. It also includes known types of modifications including labels known in the art, methylation, "caps", substitution of one or more of the naturally occurring nucleotides with an analog, and internucleotide modifications such as uncharged linkages (e.g., phosphorothioates, phosphorodithioates, etc.), as well as unmodified forms of the polynucleotide.

[0022] The term "amplify" is used in the broad sense to mean creating an amplification product can be made enzymatically with DNA or RNA polymerases. "Amplification," as used herein, generally refers to the process of producing multiple copies of a desired sequence, particularly those of a sample. "Multiple copies" mean at least 2 copies. A "copy" does not necessarily mean perfect sequence complementarity or identity to the template sequence. Methods for amplifying mRNA are generally known in the art, and include reverse transcription PCR (RT-PCR) and quantitative PCR (or Q-PCR) or real time PCR. Alternatively, RNA may be directly labeled as the corresponding cDNA by methods known in the art.

[0023] By "corresponding", it is meant that a nucleic acid molecule shares a substantial amount of sequence identity with another nucleic acid molecule. Substantial amount means at least 95%, usually at least 98% and more usually at least 99%, and sequence identity is determined using the BLAST algorithm, as described in Altschul et al. (1990), J. Mol. Biol. 215:403-410 (using the published default setting, i.e. parameters w=4, t=17).

[0024] A "microarray" is a linear or two-dimensional or three dimensional (and solid phase) array of discrete regions, each having a defined area, formed on the surface of a solid support such as, but not limited to, glass, plastic, or synthetic membrane. The density of the discrete regions on a microarray is determined by the total numbers of immobilized polynucleotides to be detected on the surface of a single solid phase support, such as of at least about 50/cm2, at least about 100/cm2, or at least about 500/cm2, up to about 1,000/cm2 or higher. The arrays may contain less than about 500, about 1000, about 1500, about 2000, about 2500, or about 3000 immobilized polynucleotides in total. As used herein, a DNA microarray is an array of oligonucleotide or polynucleotide probes placed on a chip or other surfaces used to hybridize to amplified or cloned polynucleotides from a sample. Since the position of each particular group of probes in the array is known, the identities of a sample polynucleotides can be determined based on their binding to a particular position in the microarray. As an alternative to the use of a microarray, an array of any size may be used in the practice of the invention, including an arrangement of one or more position of a two-dimensional or three dimensional arrangement in a solid phase to detect expression of a single gene sequence. In some embodiments, a microarray for use with the present invention may be prepared by photolithographic techniques (such as synthesis of nucleic acid probes on the surface from the 3' end) or by nucleic synthesis followed by deposition on a solid surface.

[0025] Because the invention relies upon the identification of gene expression, some embodiments of the invention determine expression by hybridization of mRNA, or an amplified or cloned version thereof, of a sample cell to a polynucleotide that is unique to a particular gene sequence. Polynucleotides of this type contain at least about 16, at least about 18, at least about 20, at least about 22, at least about 24, at least about 26, at least about 28, at least about 30, or at least about 32 consecutive basepairs of a gene sequence that is not found in other gene sequences. The term "about" as used in the previous sentence refers to an increase or decrease of 1 from the stated numerical value. Other embodiments are polynucleotides of at least or about 50, at least or about 100, at least about or 150, at least or about 200, at least or about 250, at least or about 300, at least or about 350, at least or about 400, at least or about 450, or at least or about 500 consecutive bases of a sequence that is not found in other gene sequences. The term "about" as used in the preceding sentence refers to an increase or decrease of 10% from the stated numerical value. Longer polynucleotides may of course contain minor mismatches (e.g. via the presence of mutations) which do not affect hybridization to the nucleic acids of a sample. Such polynucleotides may also be referred to as polynucleotide probes that are capable of hybridizing to sequences of the genes, or unique portions thereof, described herein. Such polynucleotides may be labeled to assist in their detection. The sequences may be those of mRNA encoded by the genes, the corresponding cDNAto such mRNAs, and/or amplified versions of such sequences. In some embodiments of the invention, the polynucleotide probes are immobilized on an array, other solid support devices, or in individual spots that localize the probes.

[0026] In other embodiments of the invention, all or part of a gene sequence may be amplified and detected by methods such as the polymerase chain reaction (PCR) and variations thereof, such as, but not limited to, quantitative PCR (Q-PCR), reverse transcription PCR (RT-PCR), and real-time PCR (including as a means of measuring the initial amounts of mRNA copies for each sequence in a sample), optionally real-time RT-PCR or real-time Q-PCR. Such methods would utilize one or two primers that are complementary to portions of a gene sequence, where the primers are used to prime nucleic acid synthesis. The newty synthesized nucleic acids are optionally labeled and may be detected directly or by hybridization to a polynucleotide of the invention. The newly synthesized nucleic acids may be contacted with polynucleotides (containing sequences) of the invention under conditions which allow for their hybridization. Additional methods to detect the expression of expressed nucleic acids include RNAse protection assays, including liquid phase hybridizations, and in situ hybridization of cells.

[0027] Alternatively, and in further embodiments of the invention, gene expression may be determined by analysis of expressed protein in a cell sample of interest by use of one or more antibodies specific for one or more epitopes of individual gene products (proteins), or proteolytic fragments thereof, in said cell sample or in a bodily fluid of a subject. The cell sample may be one of breast cancer epithelial cells enriched from the blood of a subject, such as by use of labeled antibodies against cell surface markers followed by fluorescence activated cell sorting (FACS). Such antibodies may be labeled to permit their detection after binding to the gene product. Detection methodologies suitable for use in the practice of the invention include, but are not limited to, immunohistochemistry of cell containing samples or tissue, enzyme linked immunosorbent assays (ELISAs) including antibody sandwich assays of cell containing tissues or blood samples, mass spectroscopy, and immuno-PCR.

[0028] The terms "label" or "labeled" refer to a composition capable of producing a detectable signal indicative of the presence of the labeled molecule. Suitable labels include radioisotopes, nucleotide chromophores, enzymes, substrates, fluorescent molecules, chemiluminescent moieties, magnetic particles, bioluminescent moieties, and the like. As such, a label is any composition detectable by spectroscopic, photochemical, biochemical, immunochemical, electrical, optical or chemical means.

[0029] The term "support" refers to conventional supports such as beads, particles, dipsticks, fibers, filters, membranes and silane or silicate supports such as glass slides.

[0030] "Expression" and "gene expression" include transcription and/or translation of nucleic acid material.

[0031] As used herein, the term "comprising" and its cognates are used in their inclusive sense; that is, equivalent to the term "including" and its corresponding cognates.

[0032] Conditions that "allow" an event to occur or conditions that are "suitable" for an event to occur, such as hybridization, strand extension, and the like, or "suitable" conditions are conditions that do not prevent such events from occurring. Thus, these conditions permit, enhance, facilitate, and/or are conducive to the event. Such conditions, known in the art and described herein, depend upon, for example, the nature of the nucleotide sequence, temperature, and buffer conditions. These conditions also depend on what event is desired, such as hybridization, cleavage, strand extension or transcription.

[0033] Sequence "mutation," as used herein, refers to any sequence alteration in the sequence of a gene disclosed herein interest in comparison to a reference sequence. A sequence mutation includes single nucleotide changes, or alterations of more than one nucleotide in a sequence, due to mechanisms such as substitution, deletion or insertion. Single nucleotide polymorphism (SNP) is also a sequence mutation as used herein. Because the present invention is based on the relative level of gene expression, mutations in non-coding regions of genes as disclosed herein may also be assayed in the practice of the invention.

[0034] "Detection" or "detecting" includes any means of detecting, including direct and indirect determination of the level of gene expression and changes therein.

[0035] Unless defined otherwise all technical and scientific terms used herein have the same meaning as commonly understood to one of ordinary skill in the art to which this invention belongs.

BRIEF DESCRIPTION OF THE DRAWINGS

[0036]

Figure 1 shows a capacity plot for the ability to use the expression levels of subsets of a set of 100 expressed gene sequences to classify among 39 tumor types and subsets thereof. Expression levels of random combinations of 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 and 100 (each sampled 10 times) of the 100 sequences were used with data from tumor types and then used to predict test random sets of tumor samples (each sampled 10 times) ranging from 2 to 39 types. A plot of numbers of tumor types versus prediction accuracies for results using from 50 to 100 genes are shown as non-limiting examples. Generally, accuracy improves with higher numbers of gene sequences, where 50 gene sequences results in a more noticeable reduction in accuracy when used with about 20 or more tumor types.

Figure 2 shows an alternative presentation of the data used with respect to Figure 1. A plot of numbers of gene sequences used, ranging from 50-100, versus prediction accuracies for various representative numbers of tumor types is shown. The plotted lines, from top to bottom, are of the results from 2,10, 20, 30, and 39 tumor types, respectively.

Figure 3 shows the performance of using all genes from a first set of 74 gene sequences and a second set of 90 gene sequences to classify various numbers of tumor types. Generally, the accuracy of the two sets are very similar, with the set of 74 displaying a more noticeable higher accuracy with about 28 or more (up to 39) tumor types.

Figure 4 shows a capacity plot for the ability to use the expression levels of all or portions of a first set of 74 expressed gene sequences to classify among 39 tumor types and subsets thereof. Expression levels of random combinations of 50, 55, 60, 65, and 70 (each sampled 10 times) as well as all 74 of the sequences were used with data from tumor types and then used to predict test random sets of tumor samples (each sampled 10 times) ranging from 2 to 39 types. A plot of numbers of tumor types versus prediction accuracies for results using from 50 to 74 genes are shown as non-limiting examples. Generally, accuracy improves with higher numbers of gene sequences, with the use of 74 genes being more noticeable as providing the highest accuracies, and 50 gene sequences producing the lowest accuracies, winen used with about 20 or more tumor types.

Figure 5 shows an alternative presentation of the data used with respect to Figure 4. A plot of numbers of gene sequences used, ranging from 50-74, versus prediction accuracies for various representative numbers of tumor types is shown. The plotted lines, from top to bottom, are of the results from 2, 10, 20, 30, and 39 tumor types, respectively.

Figure 6 shows a capacity plot for the ability to use the expression levels of subsets of a set of 90 expressed gene sequences to classify among 39 tumor types and subsets thereof. Expression levels of random combinations of 50, 55, 60, 65, 70, 75, 80, and 85 (each sampled 10 times) as well as all 90 of the sequences were used with data from tumor types and then used to predict test random sets of tumor samples (each sampled 10 times) ranging from 2 to 39 types. A plot of numbers of tumor types versus prediction accuracies for results using from 50 to 90 genes are shown as non-limiting examples. Generally, accuracy improves with higher numbers of gene sequences, winere 50 gene sequences results in noticeably reduced accuracy when used with about 20 or more tumor types.

Figure 7 shows an alternative presentation of the data used with respect to Figure 6. A plot of numbers of gene sequences used, ranging from 50-90, versus prediction accuracies for various representative numbers of tumor types is shown. The plotted lines, from top to bottom, are of the results from 2, 10, 20, 30, and 39 tumor types, respectively.

Figures 8A-8D show a "tree" that classifies tumor types covered herein as well as additional known tumor types. It was constructed mainly according to "Cancer, Principles and Practice of Oncology, (DeVito, Heilman and Rosenberg), 6th edition". Thus beginning with a "tumor of unknown origin" (or "tuo"), the first possibilities are that it is either of a germ cell or non-germ cell origin. If it is the former, then it may be of ovary or testes origin. Within those of testes origin, the tumor may be of seminoma origin or an "other" origin.

[0037] If the tumor is of a non-germ cell origin, then it is either of a epithelial or non-epithelial origin. If it is the former, then it is either squamous or non-squamous origin. Squamous origin tumors are of cervix, esophagus, larynx, lung, or skin in origin. Non-squamous origin tumors are of urinary bladder, breast, carcinoid-intestine, cholangiocarcinoma, digestive, kidney, liver, lung, prostate, reproductive system, skin-basal cell, or thyroid-follicular-papillary origin. Among those of digestive origin, the tumors are of small and large bowel, stomach-adenocarcinoma, bile duct, esophagus, gall bladder, and pancreas in origin. The esophagus origin tumors may be of either Barrett's esophagus or adenocarcinoma types. Of the reproductive system origin tumors, they may be of cervix adenocarcinoma type, endometrial tumor, or ovarian origin. Ovarian origin tumors are of the clear, serous, mucinous, and endometroid types.

[0038] If the tumor is of non-epithelial origin, then it is of adrenal gland, brain, GIST (gastrointestinal stromal tumor), lymphoma, meningioma, mesothelioma, sarcoma, skin melanoma, or thyroid-medullary origin. Of the lymphomas, they are B cell, Hodgkin's, or T cell type. Of the sarcomas, they are leimyosarcoma, osteosarcoma, soft-tissue sarcoma, soft tissue MFH (malignant fibrous histiocytoma), soft tissue sarcoma synovial, soft tissue Ewing's sarcoma, soft tissue fibrosarcoma, and soft tissue rhabdomyosarcoma types.

DETAILED DESCRIPTION OF MODES OF PRACTICING THE INVENTION

[0039] This invention provides methods for the use of gene expression information to classify tumors in a more objective manner than possible with conventional pathology techniques. The invention is based in part on the results of randomly reducing the number of gene sequences used to classify a tumor sample as one of a plurality of tumor types, such as the 34 tumor types described below and in U. S. Provisional Application 60/577,084, filed June 4, 2004. A total number of 16,948 genes, which were filtered down from a larger set based upon removal of genes that display low or constant signals in the samples used was used for both cross-validation and prediction accuracies as described in the examples below. 100 random selections of 50, 100, 150, 200, 250, 300, 400, 500, 600, 700, 800, 900, 1000, 1200, 1400, 1600, 1800, 2000, 2200, 2400, 2600, 2800, 3000 and more genes from the total were selected and used for classification as described herein.

[0040] Thus in a first aspect, the invention provides a method of classifying a cell containing sample as including a tumor cell of (or from) a type of tissue or a tissue origin. The method comprises determining or measuring the expression levels of 50 or more transcribed sequences from cells in a cell containing sample obtained from a human subject, and classifying the sample as containing, by eliminating one or more tumor types from consideration, tumor cells of an epithelial or non-epithelial tissue type including a germ cell tumor or a sarcoma based on the expression levels of said sequences.

[0041] In some embodiments of the invention, the expression of more than 50% of said transcribes sequences are not correlated with expression of another one of said transcribed sequences; and/or the 50 or more transcribes sequences are not selected based upon supervised learning using known tumor samples, on the level of correlation between their expression and said plurality of tumor types, or on their rank in a correlation between their expression and said plurality of tumor types.

[0042] The classifying is based upon a comparison of the expression levels of the 50 or more transcribed sequences in the cells of the sample to their expression levels in known tumor samples and/or known non-tumor samples. Alternatively, the classifying is based upon a comparison of the expression levels of the 50 or more transcribed sequences to the expression of reference sequences in the same samples, relative to, or based on, the same comparison in known tumor samples and/or known non-tumor samples. Thus as a non-limiting example, the expression levels of the gene sequences may be determined in a set of known tumor samples to provide a database against which the expression levels detected or determined in a cell containing sample from a subject is compared. The expression level(s) of gene sequence(s) in a sample also may be compared to the expression level(s) of said sequence(s) in normal or non-cancerous cells, preferably from the same sample or subject. As described below and in embodiments of the invention utilizing Q-PCR or real time Q-PCR, the expression levels may be compared to expression levels of reference genes in the same sample or a ratio of expression levels may be used.

[0043] The selection of 50 or more gene sequences to use may be random, or by selection based on various criteria. As one non-limiting example, the gene sequences may be selected based upon unsupervised learning, including clustering techniques. As another non-limiting example, selection may be to reduce or remove redundancy with respect to their ability to classify tumor type. For example, gene sequences are selected based upon the lack of correlation between their expression and the expression of one or more other gene sequences used for classifying. This is accomplished by assessing the expression level of each gene sequence in the expression data set for correlation, across the plurality of samples, with the expression level of each other gene in the data set to produce a correlation matrix of correlation coefficients. These correlation determinations may be performed directly, between expression of each pair of gene sequences, or indirectly, without direct comparison between the expression values of each pair of gene sequences.

[0044] A variety of correlation methodologies may be used in the correlation of expression data of individual gene sequences within the data set. Non-limiting examples include parametric and non-parametric methods as well as methodologies based on mutual information and non-linear approaches. Non-limiting examples of parametric approaches include Pearson correlation (or Pearson r, also referred to as linear or product-moment correlation) and cosine correlation. Non-limiting examples of non-parametric methods include Spearman's R (or rank-order) correlation, Kendall's Tau correlation, and the Gamma statistic. Each correlation methodology can be used to determine the level of correlation between the expressions of individual gene sequences in the data set. The correlation of all sequences with all other sequences is most readily considered as a matrix. Using Pearson's correlation as a non-limiting example, the correlation coefficient r in the method is used as the indicator of the level of correlation. When other correlation methods are used, the correlation coefficient analogous to r may be used, along with the recognition of equivalent levels of correlation corresponding to r being at or about 0.25 to being at or about 0.5.

[0045] The correlation coefficient may be selected as desired to reduce the number of correlated gene sequences to various numbers. In some embodiments of the invention using r, the selected coefficient value may be of about 0.25 or higher, about 0.3 or higher, about 0.35 or higher, about 0.4 or higher, about 0.45 or higher, or about 0.5 or higher. The selection of a coefficient value means that where expression between gene sequences in the data set is correlated at that value or higher, they are possibly not included in a subset of the invention. Thus in some embodiments, the method comprises excluding or removing (not using for classification) one or more gene sequences that are expressed in correlation, above a desired correlation coefficient, with another gene sequence in the tumor type data set. It is pointed out, however, that there can be situations of gene sequences that are not correlated with any other gene sequences, in which case they are not necessarily removed from use in classification.

[0046] Thus the expression levels of gene sequences, where more than about 10%, more than about 20%, more than about 30%, more than about 40%, more than about 50%, more than about 60%, more than about 70%, more than about 80%, or more than about 90% of the levels are not correlated with that of another one of the gene sequences used, may be used in the practice of the invention. Correlation between expression levels may be based upon a value below about 0.9, about 0.8, about 0.7, about 0.6, about 0.5, about 0.4, about 0.3, or about 0.2. The ability to classify among classes with elusion of the expression levels of some gene sequences is present because expression of the gene sequences in the subset is correlated with expression of the gene sequences excluded from the subset. So no information was lost because information based on the expression of the excluded gene sequences is still represented by sequences retained in the subset. Therefore, expression of the gene sequences of the subset has information content relevant to properties and/or characteristics (or phenotype) of a cell. This has application and relevance to the classification of additional tumor type classes not included as part of the original gene expression data set which can be classified by use of a subset of the invention because based on the redundancy of information between expression of sequences in the subset and sequences expressed in those additional classes. Thus the invention may be used to classify cells as being a tumor type beyond the plurality of known classes used to generate the original gene expression data set.

[0047] Selection of gene sequences based upon reducing correlation of expression to a particular tumor type may also be used. This also reflects a discovery of the present invention, based upon the observation that expression levels that were most highly correlated with one or more tumor types was not necessarily of greatest value in classification among different tumor types. This is reflected both by the ability to use randomly selected gene sequences for classification as well as the use of particular sequences, as described herein, which are not expressed with the most significant correlation with one or more tumor types. Thus the invention may be practiced without selection of gene sequences based upon the most significant P values or a ranking based upon correlation of gene expression and one or more tumor types. Thus the invention may be practiced without the use of ranking based methodologies, such as the Kruskal-Wallis H-test.

[0048] The gene sequences used in the practice of the invention may include those which have been observed to be expressed in correlation with particular tumor types, such as expression of the estrogen receptor, which has been observed to be expressed in correlation with some breast and ovarian cancers. In some embodiments of the invention, however, the invention is practiced with use of the expression level of at least one gene sequence that has not been previously identified as being associated with any of the tumor types being classified. Thus the invention may be practiced without all of the gene sequences having previously been associated or correlated with expression in the 2 or more (up to 39 or more) tumor types to which a cell containing sample may be classified.

[0049] While the invention is described mainly with respect to human subjects, samples from other subjects may also be used. All that is necessary is the ability to assess the expression levels of gene sequences in a plurality of known tumor samples such that the expression levels in an unknown or test sample may be compared. Thus the invention may be applied to samples from any organism for which a plurality of expressed sequences, and a plurality of known tumor samples, are available. One non-limiting example is application of the invention to mouse samples, based upon the availability of the mouse genome to permit detection of expressed murine sequences and the availability of known mouse tumor samples or the ability to obtain known samples. Thus, the invention is contemplated for use with other samples, including those of mammals, primates, and animals used in clinical testing (such as rats, mice, rabbits, dogs, cats, and chimpanzees) as non-limiting examples.

[0050] While the invention is readily practiced with the use of cell containing samples, any nucleic acid containing sample which may be assayed for gene expression levels may be used in the practice of the invention. Without limiting the invention, a sample of the invention may be one that is suspected or known to contain tumor cells. Alternatively, a sample of the invention may be a "tumor sample" or "tumor containing sample" or "tumor cell containing sample" of tissue or fluid isolated from an individual suspected of being afflicted with, or at risk of developing, cancer. Non-limiting examples of samples for use with the invention include a clinical sample, such as, but not limited to, a fixed sample, a fresh sample, or a frozen sample. The sample may be an aspirate, a cytological sample (including blood or other bodily fluid), or a tissue specimen, which includes at least some information regarding the in situ context of cells in the specimen, so long as appropriate cells or nucleic acids are available for determination of gene expression levels. The invention is based in part on the discovery that results obtained with frozen tissue sections can be validly applied to the situation with fixed tissue or cell samples and extended to fresh samples.

[0051] Non-limiting examples of fixed samples include those that are fixed with formalin or formaldehyde (including FFPE samples), with Boudin's, glutaldehyde, acetone, alcohols, or any other fixative, such as those used to fix cell or tissue samples for immunohistochemistry (IHC). Other examples include fixatives that precipitate cell associated nucleic acids and proteins. Given possible complications in handling frozen tissue specimens, such as the need to maintain its frozen state, the invention may be practiced with non-frozen samples, such as fixed samples, fresh samples, including cells from blood or other bodily fluid or tissue, and minimally treated samples. In some applications of the invention, the sample has not been classified using standard pathology techniques, such as, but not limited to, immunohistochemistry based assays.

[0052] In some embodiments of the invention, the sample is classified as containing a tumor cell of a type selected from the following 53, and subsets thereof: Adenocarcinoma of Breast, Adenocarcinoma of Cervix, Adenocarcinoma of Esophagus, Adenocarcinoma of Gall Bladder, Adenocarcinoma of Lung, Adenocarcinoma of Pancreas, Adenocarcinoma of Small-Large Bowel, Adenocarcinoma of Stomach, Astrocytoma, Basal Cell Carcinoma of Skin, Cholangiocarcinoma of Liver, Clear Cell Adenocarcinoma of Ovary, Diffuse Large B-Cell Lymphoma, Embryonal Carcinoma of Testes, Endometrioid Carcinoma of Uterus, Ewings Sarcoma, Follicular Carcinoma of Thyroid, Gastrointestinal Stromal Tumor, Germ Cell Tumor of Ovary, Germ Cell Tumor of Testes, Glioblastoma Multiforme, Hepatocellular Carcinoma of Liver, Hodgkin's Lymphoma, Large Cell Carcinoma of Lung, Leiomyosarcoma, Liposarcoma, Lobular Carcinoma of Breast, Malignant Fibrous Histiocytoma, Medulary Carcinoma of Thyroid, Melanoma, Meningioma, Mesothelioma of Lung, Mucinous Adenocarcinoma of Ovary, Myofibrosarcoma, Neuroendocrine Tumor of Bowel, Oligodendroglioma, Osteosarcoma, Papillary Carcinoma of Thyroid, Pheochromocytoma, Renal Cell Carcinoma of Kidney, Rhabdomyosarcoma, Seminoma of Testes, Serous Adenocarcinoma of Ovary, Small Cell Carcinoma of Lung, Squamous Cell Carcinoma of Cervix, Squamous Cell Carcinoma of Esophagus, Squamous Cell Carcinoma of Larynx, Squamous Cell Carcinoma of Lung, Squamous Cell Carcinoma of Skin, Synovial Sarcoma, T-Cell Lymphoma, and Transitional Cell Carcinoma of Bladder.

[0053] In other embodiments of the invention, the sample is classified as containing a tumor cell of a type selected from the following 34, and subsets thereof: adrenal, brain, breast, carcinoid-intestine, cervix (squamous cell), cholangiocarcinoma, endometrium, germ-cell, GIST (gastrointestinal stromal tumor), kidney, leiomyosarcoma, liver, lung (adenocarcinoma, large cell), lung (small cell), lung (squamous), lymphoma (B cell), Lymphoma (Hodgkins), meningioma, mesothelioma, osteosarcoma, ovary (clear cell), ovary (serous cell), pancreas, prostate, skin (basal cell), skin (melanoma), small and large bowel; soft tissue (liposarcoma); soft tissue (MFH or Malignant Fibrous Histiocytoma), soft tissue (Sarcoma-synovial), testis (seminoma), thyroid (follicular-papillary), thyroid (medullary carcinoma), and urinary bladder.

[0054] In further embodiments of the invention, the sample is classified as containing a tumor cell of a type selected from the following 39, and subsets thereof: adrenal gland, brain, breast, carcinoid-intestine, cervix-adenocarcinoma, cervix-squamous, endometrium, gall bladder, germ cell-ovary, GIST, kidney, leiomyosarcoma, liver, lung-adenocarcinoma-large cell, lung-small cell, lung-squamous, lymphoma-B cell, lymphoma-Hodgkin's, lymphoma-T cell, meningioma, mesothelioma, osteosarcoma, ovary-clear cell, ovary-serous, pancreas, prostate, skin-basal cell, skin-melanoma, skin-squamous, small and large bowel, soft tissue-liposarcoma, soft tissue-MFH, soft tissue-sarcoma-synovial, stomach-adenocarcinoma, testis-other (or non-seminoma), testis-seminoma, thyroid-follicular-papillary, thyroid-medullary, and urinary bladder.

[0055] The methods of the invention may also be applied to classify a cell containing sample as containing a tumor cell of a tumor of a subset of any of the above sets. The size of the subset will usually be small, composed of two, three, four, five, six, seven, eight, nine, or ten of the tumor types described above. Alternatively, the size of the subset may be any integral number up to the full size of the set. Thus embodiments of the invention include classification among 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21,22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41,42, 43, 44, 45, 46, 47, 48, 49, 50, 51, or 52 of the above types. In some embodiments, the subset will be composed of tumor types that are of the same tissue or organ type. Alternatively, the subset will be composed of tumor types of different tissues or organs. In some embodiments, the subset vwll include one or more types selected from adrenal gland, brain, carcinoid-intestine, cervix-adenocarcinoma, cervix-squamous, gall bladder, germ cell-ovary, GIST, leiomyosarcoma, liver, meningioma, osteosarcoma, skin-basal cell, skin-squamous, soft tissue-liposarcoma, soft tissue-MFH, soft tissue-sarcoma-synovial, testis-other (or non-seminoma), testis-seminoma, thyroid-follicular-papillary, and thyroid-medullary.

[0056] Classification among subsets of the above tumor types is demonstrated by the results shown in Figures 1 and 2, where the expression levels of as few as 50 or more genes sequences can be used to classify among random samples of 2 tumor types among those in the set of 39 listed above. Expression levels of 50-100 gene sequences (that were randomly selected) can be used to classify among 2 to 39 tumor types with varying degrees of accuracy. The invention may be practiced with the expression levels of 50 or more, about 55 or more, about 60 or more, about 65 or more, about 70 or more, about 75 or more, about 80 or more, about 85 or more, about 90 or more, about 100 or more, about 110 or more, about 120 or more, about 130 or more, about 140 or more, about 150 or more, about 200 or more, about 250 or more, about 300 or more, about 350 or more, or about 400 or more transcribed sequences as found in the human "transcriptome" (transcribed portion of the genome). The invention may also be practiced with expression levels of 50-60 or more, about 60-70 or more, about 70-80 or more, about 80-90 or more, about 90-100 or more, about 100-110 or more, about 110-120 or more, about 120-130 or more, or about 130-140 or more transcribed sequences. In some embodiments of the invention, the transcribed genes may be randomly picked or include all or some of the specific genes sequences disclosed herein. As demonstrated herein, classification with accuracies of about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, about 90%, or about 95% or higher can be performed by use of the instant invention.

[0057] In other embodiments, the gene expression levels of other gene sequences may be determined along with the above described determinations of expression levels for use in classification. One non-limiting example of this is seen in the case of a microarray based platform to determine gene expression, where the expression of other gene sequences is also measured. Where those other expression levels are not used in classification, they may be considered the results of "excess" transcribed sequences and not critical to the practice of the invention. Alternatively, and where those other expression levels are used in classification, they are within the scope of the invention, where the description of using particular numbers of sequences does not necessarily exclude the use of expression levels of additional sequences. In some embodiments, the invention includes the use of expression level(s) from one or more "excess" gene sequences, such as those which may provide information redundant to one or more other gene sequences used in a method of the invention.

[0058] Because classification of a sample as containing cells of one of the above tumor types inherently also classifies the tissue or organ site origin of the sample, the methods of the invention may be applied to classification of a tumor sample as being of a particular tissue or organ site of the patient. This application of the invention is particularly useful in cases where the sample is of a tumor that is the result of metastasis by another tumor. In some embodiments of the invention, the tumor sample is classified as being one of the following 24: Adrenal, Bladder, Bone, Brain, Breast, Cervix, Endometrium, Esophagus, Gall Bladder, Kidney, Larynx, Liver, Lung, Lymph Node, Ovary, Pancreas, Prostate, Skin, Soft Tissue, Small/Large Bowel, Stomach, Testes, Thyroid, and Uterus.

[0059] While the invention also provides for classification as one of the above tumor types based upon comparisons to the expression levels of sequences in the 39 tumor types, it is possible that a higher level of confidence in the classification is desired. If an increase in the confidence of the classification is preferred, the classification can be adjusted to identify the tumor sample as being of a particular origin or cell type as shown in Figure 8. Thus an increase in confidence can be made in exchange for a decrease in specificity as to tumor type by identification of origin or cell type.

[0060] The classification of a cell containing sample as having a tumor cell of one of the 39 tumor types above inherently also classifies the tissue or organ site origin of the sample. For example, the identification of a sample as being cervix-squamous necessarily classifies the tumor as being of cervical origin, squamous cell type (and thus epithelial rather than non-epithelial in origin) as shown in Figure 8. It also means that the tumor was necessarily not germ cell in origin. Thus, the methods of the invention may be applied to classification of a tumor sample as being of a particular tissue or organ site of a subject or patient. This application of the invention is particularly useful in cases where the sample is of a tumor that is the result of metastasis by another tumor.

[0061] The practice of the invention to classify a cell containing sample as having a tumor cell of one of the above types is by use of an appropriate classification algorithm that utilizes supervised learning to accept 1) the levels of expression of the gene sequences in a plurality of known tumor types as a training set and 2) the levels of expression of the same genes in one or more cells of a sample to classify the sample as having cells of one of the tumor types. Further discussion of this is provided in the Example section herein. The levels of expression may be provided based upon the signals in any format, including nucleic acid expression or protein expression as described herein.

[0062] As would be evident to the skilled practitioner, the range of classification is affected by the number of tumor types as well as the number of samples for each tumor type. But given adequate samples of the full range of human tumors as provided herein, the invention is readily applied to the classification of those tumor types as well as additional types.

[0063] Non-limiting examples of classification algorithms that may be used in the practice of the invention include supervised learning algorithms, machine learning algorithms, linear discriminant analysis, attribute selection algorithms, and artificial neural networks (ANN). In preferred embodiments of the invention, a distance-based classification algorithm, such as the k-nearest neighbor (KNN) algorithm, or support vector machine (SVM) are used.

[0064] The use of KNN is in some embodiments of the invention and is discussed further as a non-limiting representative example. KNN can be used to analyze the expression data of the genes in a "training set" of known tumor samples including all 39 of the tumor types described herein. The training data set can then be compared to the expression data for the same genes in a cell containing sample. The expression levels of the genes in the sample are then compared to the training data set via KNN to identify those tumor samples with the most similar expression patterns. As a non-limiting example, the five “nearest neighbors” may be identified and the tumor types thereof used to classify the unknown tumor sample. Of course other numbers of "nearest neighbors" may be used. Non-limiting examples include less than 5, about 7, about 9, or about 11 or more "nearest neighbors".

[0065] As a hypothetical example, if the five "nearest neighbors” of an unknown sample are four B cell lymphomas and one T cell lymphoma, then the classification of the sample as being of a B cell lymphoma can be made with great accuracy. This has been used with 84% or greater accuracy, such as 90%, as described in the Examples.

[0066] The classification ability may be combined with the inherent nature of the classification scheme to provide a means to increase the confidence of tumor classification in certain situations. For example, if the five "nearest neighbors" of a sample are three ovary clear cell and two ovary serous tumors, confidence can be improved by simply treating the tumors as being of ovarian origin and treating the subject or patient (from whom the sample was obtained) accordingly. See Figure 8. This is an example of trading off specificity in favor of increased confidence. This provides the added benefit of addressing the possibility that the unknown sample was a mucinous or endometroid tumor. Of course the skilled practitioner is free to treat the tumor as one or both of these two most likely possibilities and proceeding in accordance with that determination.

[0067] Because the developmental lineage of tumor cells in certain tumor types (e.g., germ cells) can be complex and involve multiple cell types, Figure 8 may appear to be oversimplified. However, it serves as a good basis to relate known histopathology and to serve as a "guide tree" for analyzing and relating tumor-associated gene expression signatures.

[0068] The inherent nature of the classification scheme also provides a means to increase the confidence of tumor classification in cases wherein the "nearest neighbors" are ambiguous. For example, if the five "nearest neighbors" were one urinary bladder, one breast, one kidney, one liver, and one prostate, the classification can simply be that of a non-squamous cell tumor. Such a determination can be made with significant confidence and the subject or patient from whom the sample was obtained can be treated accordingly. Without being bound by theory, and offered solely to improve the understanding of the invention, the last two examples reflect the similarities in gene expression of cells of a similar cell type and/or tissue origin.

[0069] Embodiments of the invention include use of the methods and materials described herein to identify the origin of a cancer from a patient. Thus given a sample containing tumor cells, the tissue origin of the tumor cells is identified by use of the present invention. One non-limiting example is in the case of a subject with an inflamed lymph node containing cancer cells. The cells may be from a tissue or organ that drains into the lymph node or it may be from another tissue source. The present invention may be used to classify the cells as being of a particular tumor or tissue type (or origin) which allows the identification of the source of the cancer cells. In an alternative non-limiting example, the sample (such as that from a lymph node) contains cells, which are first assayed by use of the invention to classify at least one cell as being a tumor cell of a tissue type or origin. This is then used to identify the source of the cancer cells in the sample. Both of these are examples of the advantageous use of the invention to save time, effort, and cost in the use of other cancer diagnostic tests.

[0070] In further embodiments, the invention is practiced with a sample from a subject with a previous history of cancer. As a non-limiting example, a cell containing sample (from the lymph node or elsewhere) of the subject may be found to contain cancer cells such that the present invention may be used to determine whether the cells are from the same or a different tissue from that of the previous cancer. This application of the invention may also be used to identify a new primary tumor, such as the case where new cancer cells are found in the liver of a subject who previously had breast cancer. The invention may be used to identify the new cancer cells as being the result of metastasis from the previous breast cancer (or from another tumor type, whether previously identified or not) or as a new primary occurrence of liver cancer. The invention may also be applied to samples of a tissue or organ where multiple cancers are found to determine the origin of each cancer, as well as whether the cancers are of the same origin.

[0071] While the invention may be practiced with the use of expression levels of a random group of expressed gene sequences, the invention also provides exemplary gene sequences for use in the practice of the invention. The invention includes a first group of 74 gene sequences from which 50 or more may be used in the practice of the invention. The 50 to 74 gene sequences may be used along with the determination of expression levels of additional sequences so long as the expression levels of gene sequences from the set of 74 are used in classifying. A non-limiting example of such embodiments of the invention is where the expression of the 74 gene sequences, or at least 50 (or 50 to about 90) members thereof, is measured along with the expression levels of a plurality of other sequences, such as by use of a microarray based platform used to perform the invention. Where those other expression levels are not used in classification, they may be considered the results of "excess" transcribed sequences and not critical to the practice of the invention. Alternatively, and where those other expression levels are used in classification, they are within the scope of the invention, where the use of the above described sequences does not necessarily exclude the use of expression levels of additional sequences.

[0072] mRNA sequences corresponding to a set of 74 gene sequences for use in the practice of the invention are provided in the attached Sequence Listing. A listing of the SEQ ID NOs, with corresponding identifying information, including accession numbers and other information, is provided by the following. Table 1

[0073] As would be understood by the skilled person, detection of expression of any of the above identified sequences, as well as sequences of the set of 90 below, or the sequences provided in the attached Sequence Listing may be performed by the detection of expression of any appropriate portion or fragment of these sequences. Preferably, the portions are sufficiently large to contain unique.sequences relative to other sequences expressed in a cell containing sample. Moreover, the skilled person would recognize that the disclosed sequences represent one strand of a double stranded molecule and that either strand may be detected as an indicator of expression of the disclosed sequences. This follows because the disclosed sequences are expressed as RNA molecules in cells which are preferably converted to cDNA molecules for ease of manipulation and detection. The resultant cDNA molecules may have the sequences of the expressed RNA as well as those of the complementary strand thereto. Thus either the RNA sequence strand or the complementary strand may be detected. Of course is it also possible to detect the expressed RNA wthout conversion to cDNA.

[0074] In some embodiments of the invention, the expression levels of gene sequences is measured by detection of expressed sequences in a cell containing sample as hybridizing to the following oligonucleotides, which correspond to the above sequences as indicated by the accession numbers provided. >AF133587 CCCG GAT CG CCAT CAGTGTCAT CGAGTT CAAACCCT GAG CCCTT CATT CACCT CTGT GAG (SEQ ID NO:75). >BC017742 TGCCCTTGCTCTGTGTCATCTCAGTCATTTGACTTAGAAAGTGCCCTTCAAAAGGACCCT (SEQ ID NO:76) >BF437393 GGAGGGAGGGCTAATTATATATTTTGTTGTTCCTCTATACTTTGTTCTGTTGTCTGCGCC (SEQ ID NO : 77) >AI620495 CAGTTTGGATTGTATAATAACGCCAAGCCCAGTTGTAGTCGTTTGAGTGCAGTAATGAAA (SEQ ID N0.78) >AK000380 AAAT CAGAGTAACCCTTT CT GT ATT GAGTGCAGTGTTTTTTACT CTTTT CT CAT GCACAT (SEQ ID NO:79) >BC009237 TGCCT GG CACAAAGAAGGAAG AAT AT AAAT GAT AGTT CGACT CGT CT GT GGAAGAACTT A (SEQ ID NO:80) >BC008765 AGTCTTTTGCTTTTGGCAAAACTCTACTTAATCCAATGGGTTTTTCCCTGTACAGTAGAT (SEQ ID NO:81) >BC001504 GGTTACTGTGGGTGGAATAGTGGAGGCCTTCAACTGATTAGACAAGGCCCGCCCACATCT (SEQ ID NO:82) >NM_019894 TAAAATGCACTGCCCTACTGTTGGTATGACTACCGTTACCTACTGTTGTCATTGTTATTA (SEQ ID NO:83) >BF224381 TTCTCTTTT G GG GGCAAACACT ATGTCCTTTT CTTTTT CT AGAT ACAGTT AATT CCT GG A (SEQ ID NO:84) >AL157475 AAG ACCCACACCCTGTAGCAAT ACCAAGT GCT ATT ACAT AAT CAAT GGACGATTT AT ACT (SEQ ID NO:85) >AY033998 AGTGTTGCAAGTTTCCTTTAAAACCAACAAAGCCCACAAGTCCTGAATTTCCCATTCTTA (SEQ ID NO:86) >H07885 G T CACT G T CAT AG CAG CTGTGATTT CACAAG G AAG G G TG CTG CAG GGG G ACCT G GTTG AT (SEQ ID NO:87) >NM_004496 TTTCATCCAGTGTTATGCACTTTCCACAGTTGGTGTTAGTATAGCCAGAGGGTTTCATTA (SEQ ID NO:88) >AA846824 GGGAAGTAGGGATTATTCGTTTAAATTCAATCGCGAGCACCAAGTCGGACTGGCCGGGGA (SEQ ID NO:89) >BC017586 GGGACCAGGCCCTGGGACAGCCATGTGGCTCCAAATGACTAAATGTCAGCTCAAAAACCA (SEQ ID NO:90) >AA456140 T CCGTTT ATGGAGGCAATT CCAT AT CCTTT CTT GAACGCACATT CAGCTTACCCCAGAGA (SEQ ID NO:91) >NM_002283 AGAGTTAAGCCACTTCCTGGGTCTCCTTCTTATGACTGTCTATGGGTGCATTGCCTTCTG (SEQ ID NO:92) >AL023657 GTGGCCTGAGTAATGCATTATGGGTGGTTTACCATTTCTTGAGGTAAAAGCATCACATGA (SEQ ID NO:93) >BC001639 ACACATGCATGTGTCT GT GT AT GT GT GAAT GT GAGAGAGACACAGCCCT CCTTT CAGAAG (SEQ ID NO:94) >BC015754 TCTGTAACTGCACAACCCTGGGGTTTGCTGCAGAGCTATTTCTTTCCATGTAAAGTAGTG (SEQ ID NO:95) >AF332224 AAACACT CTTT CCGACT CCAG AGG AG AAGCT GG CAG CT CTCTGT AAGAAAT ATGCT GAT C (SEQ ID NO: 96) >BC001270 GCTTCCTCTATCGCCCAATGCAAAATCGATGAAATGGGGAGTTCTCTGGGCCAGGCCACA (SEQ ID NO:97) >AI147926 GTAGAAT CCT CTGTT CAT AAT GAACAAGAT GAACCAATGTGGATT AGAAAGAAGT CCGAG (SEQ ID NO:98) >AW298545 CT GTTTT AAAACT GAAT GGCACGAAATTGTTTT CCT CAACT CGGAGATT CCT GT ATGGAG (SEQ ID NO:99) >AI802118 AAT AAAT AGT AG CT CT GCT GAT GAT G ACGTT GAT AACCAAACT GTTCTGTGGTCTT AAGT (SEQ ID NO: 100) >AI683181 CAAACAGCCCGGTCTTGATGCAGGAGAGTCTGGAAAAGGAAGAAAATGGTTTCAGTTTCA (SEQ ID NO:101) >M95585 AACATGGACCATCCAAATTTATGG CCGTATCAAATG GTAGCTGAAAAAACTATATTTGAG (SEQ ID NO: 102) >AK027147 TTGTAAT CAT G CCAATT CCAGAT CAAT AACT GCATGTCT GTTCTTTGGT AG AAAT AG CTT (SEQ ID NO: 103) >AW291189 AAAGATT ATT AACCCAAAT CACCTTT CTT GCTT ACT CCAGAT GCCT CAG CCT CT GAT AT A (SEQ ID NO:104) >AI632869 G ACTT CCTTT AGG AT CT CAGG CTT CT G CAG TT CT CAT GACT CCT ACTTTT CAT CCT AGT C (SEQ ID NO:105) >BC006537 CTGTAT ATTTT GCAAT AGTT ACCT CAAGGCCT ACT G ACCAAATT GTT GT GTT GAGAT GAT (SEQ ID NO: 106) >R61469 TGTT CAAACAGACTTTAACCT CT GCAT CAT ACTT AACCCT G CG ACAT GCGT ACAGT ATG C (SEQ ID NO: 107) >BC009084 T GAGT CATATACATTTACT GACCACT GTT GCTT GTT GCT CACT GTGCTGCTTTT CCAT GA (SEQ ID NO: 108) >N64339 CT GAAAT GT GGAT GT GATT GCCT CAAT AAAGCT CGT CCCCATT GCTT AAGCCTT CAAAAA (SEQ ID NO: 109) >AI200660 AT CAAGAAAACCT AAT CTT CT GACT CCCAGGCCAGG AT GTTTT ATTT CT CACAT CAT GT C (SEQ ID NO: 110) >AK054605 TT CATTT CCAAACAT CAT CTTT AAGACT CCAAGGATTTTT CCAGGCACAGTGGCT CAT AC (SEQ ID NO: 111) >NM_006115 AGTTAGAAATAGAATCTGAATTTCTAAAGGGAGATTCTGGCTTGGGAAGTACATGTAGGA (SEQ ID NO:112) >X96757 CAATTTT CTTTTT ACT CCCCCT CTT AAGGGGGCCTT GG AAT CT AT AGT AT AGAAT GAACT (SEQ ID NO: 113) >AI804745 GGGTGGAGTTTCAGTGAGAATAAACGTGTCTGCCTTTGTGTGTGTGTATATATACAGAGA (SEQ ID NO:114) >AJ000388 CTCGCTCATTTTTTACCATGTTTTCCAGTCTGTTTAACTTCTGCAGTGCCTTCACTACAC (SEQ ID NO: 115) >BC008764 CTTTGG GCCG AG CACT GAAT GT CTT GT ACTTT AAAAAAAT GTTTCT GAGACCT CTTTCTA (SEQ ID NO:116) >AI309080 CTGGACCCTTGGAGCAGTGTTGTGTGAACTTGCCTAGAACTCTGCCTTCTCCGTTGTCAA (SEQ ID NO: 117) >AA865917 CCACCT CCTT CGACCT CCACTGCGCCCCACCT CCCT GCCT GT GT GT GTTATTT CAAAGGA (SEQ ID NO:118) >AA946776 TCTGGCTGGTGGCCTGCGCGAGGGTGCAGTCTTACTTAAAAGACTTTCAGTTAATTCTCA (SEQ ID NO:119) >AF104032 AGATGCTGTCGGCACCATGTTTATTTATTTCCAGTGGTCATGCTCAGCCTTGCTGCTCTG (SEQ ID NO: 120) >AW194680 T CCTT CCT CTT CGGT GAATGCAGGTTATTT AAACTTT GGGAAAT GT ACTTTT AGT CT GT C (SEQ ID NO:121) >BC001293 GT CCT GT CCCT GTCT GGGAGTT GTGTT ATTTAAAGATATT CT GT AT GTT GT AT CTTTT GC (SEQ ID NO: 122) >BE962007 ATT ATATTT CAG GTGTCCT GAACAG GT CACT AG ACT CTACATT GG GCAGCCTTT AAATAT (SEQ ID NO: 123) >BI493248 AGGAATGGT ACT ACCGTT CCAGATTTT CT GT AATT GCTT CT GCAAAGTAAT AGGCTT CTT (SEQ ID NO: 124) >AF283645 CTGT ACCCAAAG GAT G CCAG AATACTAGT ATTTTT ATTTATCGT AAACAT CCACGAGT GC (SEQ ID NO: 125) >AI669760 ATTGCCCCCCTAACCAATCATGCAAACTTTTCCCCCCCTGGGGTAATTCACCAGTTAAAA (SEQ ID NO: 126) >BC001492 CCCACAGTATTT AAT GCCCTGT CAGT CCCTT CT AGT CT GACT CAATGGT AACTT GCTGTA (SEQ ID NO: 127)) >BC004453 AAAACCAACTCT CT ACT ACACAGGCCT GATAACT CT GT ACGAGGCTTCT CTAACCCCTAG (SEQ ID NO: 128) >BC010626 CTCAGACTGGGCTCCACACTCTTGGGCTTCAGTCTGCCCATCTGCTGAATGGAGACAGCA (SEQ ID NO:129) >BC013117 CCTAATGGGGATTCCTCTGGTTGTTCACTGCCAAAACTGTGGCATTTTCATTACAGGAGA (SEQ ID NO:130) >BC011949 CACT CACAATT G TT G ACT AAAAT GCTGCCTTT AAAACAT AG G AAAG T AG AAT G G TT G AGT (SEQ ID NO:131) >AW083022 CTTT GAAGGG CT G CTG CACATT GTT GAAT CCAT CGACCTTT AG CT G CAAT G GG ATCTCTA (SEQ ID NO: 132) >R08175 TGCCTCATCGATATTATAGGGGTCCATCACAACCCAACTGTGTGGCCGGATCCTGAGTCT (SEQ ID NO: 133) >NM_000065 AAAACAGACAAAAGCCTTTGCCTTCATGAAGCATACATTCATTCAGGGGTAGACACACAA (SEQ ID NO: 134) >AK025181 TAACAAACAAAGGCAGTAGCTCATCACTTGGGTAGCAGGTACCCATTTTAGGACCCTACA (SEQ ID NO: 135) >NM_003914 AT AT CAG AAGTGCCAAT AAT CGT CAT AGGCTT CT GCACGTT G GAT CAACT AAT GTTGTTT (SEQ ID NO: 136) >AI123582 AT CAT AG CCCAACCAT GT GAGAAG AAGG AG AAGG CCCCCCTTT CTT CATT AAT CT GAAAA (SEQ ID NO: 137) >BC004331 GCAGACCATTCTATCATACCTGGCAGGGCTTCTGTTTTATTTTGTAGGCTGGATGCTACC (SEQ ID NO: 138) >AI341378 ACTACAAGCCTCTTGTTTTTCACCAAAACCCTACATCTCAGGCTTACTAATTTTTGTGAT (SEQ ID NO: 139) >NM_004063 G CCAT GCATACAT G CTG CGCAT GTTTT CTT CATT CGTATGTTAGT AAAGTTTT GGTTATT (SEQ ID NO: 140) >BC012926 CACCTATTT ATTTT ACCT CTTT CCCAAACCT GG AG CATTTATG CCTAGG CTT GT CAAGAA (SEQ ID NO: 141) >AL110274 GTG G ACAT AG CCACT AACCAACT AGTT ACCTTT G GACT G CAACAAAAAAT GT GAAAAT G A (SEQ ID NO: 142) >AW473119 ACTT GT AAACCT CTTTT GCACTTT G AAAAAGAAT CCAGCGG GAT G CT CG AG CACCT GTAA (SEQ ID NO: 143) >AI685931 AATT CT CT AT AAACGGTT CACCAGCAAACCACCAATACATT CCATT GTTT GCCT AGAGAG (SEQ ID NO: 144) >BF592799 AAT GGCCCAT GCAT GOT GTTT GCAGCAGT CAATT GAGTTGAATTAGAATT CCAACCATAC (SEQ ID NO: 145) >BC000045 GAG CT CAGT ACTT GCCCT GT GAAAAT CCCAGAAGCCCCCGCT GT CAAT GTT CCCCAT CCA (SEQ ID NO: 146) >BC015582 ATGAAGCGGAATTAGGCTCCCGAGCTAAGGGACTCGCCTAGGGTCTCACAGTGAGTAGGA (SEQ ID NO: 147) >M60502 AGT G G CTATAT CAACAT CAG G G CTAGCACAT CTTT CT CT ATT AT CCTT CTATTG GAATT C (SEQ ID NO: 148) [0075] The invention also provides a second group of 90 gene sequences from which 50 or more may be used in the practice of the invention. The 50 to 90 gene sequences may be used along with the determination of expression levels of additional sequences so long as the expression levels of gene sequences from the set of 90 are used in classifying. A non-limiting example of such embodiments of the invention is where the expression of the 90 gene sequences, or at least 50 (or 50 to about 90) members thereof, is measured along with the expression levels of a plurality of other sequences, such as by use of a microarray based platform used to perform the invention. Where those other expression levels are not used in classification, they may be considered the results of "excess" transcribed sequences and not critical to the practice of the invention. Alternatively, and where those other expression levels are used in classification, they are within the scope of the invention, where the use of the above described sequences does not necessarily exclude the use of expression levels of additional sequences.

[0076] 38 members of the set of 90 are included in the first set of 74 described above. The accession numbers of these members in common between the two sets are AA456140, AA846824, AA946776, AF332224, AI620495, AI632869, AI802118, AI804745, AJ000388, AK025181, AK027147, AL157475, AW194680, AW291189, AW298545, AW473119, BC000045, BC001293, BC001504, BC004453, BC006537, BC008765, BC009084, BC011949, BC012926, BC013117, BC015754, BE962007, BF224381, BF437393, BI493248, M60502, NM_000065, NM_ 003914, NM_004063, NM_004496, NM_006115, and R61469. mRNA sequences corresponding to members of the set of 90 that.are not present in the set of 74 gene sequences are also provided in the Sequence Listing and identified as SEQ ID NOS: 149-200. The listing of identifying information for these 52 unique members by accession numbers, as well as corresponding oligonucleotide sequences which may be used in the practice of the invention, is provided by the following. >R15881 ACTT CT GGT GAT GATAAAAAT GGTTTTAT CACCCAGAT GT GAAAGAAGCTGCCTGTTTAC (SEQ ID NO:201) >AI041545 GTGGTT CT GT AAAAACGCAGAGGAAAAGAGCCAGAAGGTTT CT GTTT AATGCAT CTT GCC (SEQ ID NO:202) >NM_024423 TTTATAAGGAAGCAGCTGTCTAAAATGCAGTGGGGTTTGTTTTGCAATGTTTTAAACAGA (SEQ ID NQ:203) >AB038160 CTTATGAAGCTGGCCGGGCCACTCACGTTCAATGGTACATCTGGGTCTCTATGTGGTTCT (SEQ ID NO:204) >AK026790 GTGAGCCAGCATTTCCCATAGCTAACCCTATTCTCTTAGTCTTTCAAAATGTAGAATGGG (SEQ ID NO:205) >BC012727 CTTT ACACCT GAT AAAAT ATTTT G CG AAG AG AG GTGTTCTTTTTCCTT ACT G GTGCT GAA (SEQ ID NO:206) >BC016451 G CAT ACAT CT CAT CCACAGGG GAAG AT AAAGAT G GT CACACAAACAGTTT CCAT AAAG AT (SEQ ID NO:207) >H09748 TGAGTTCAGCATGTGTCTGTCCATTTCATTTGTACGCTTGTTCAAAACCAAGTTTGTTCT (SEQ ID NO:208) >NM_006142 AAGACCGAGACTGAGGGAAAGCATGTCTGCTGGGTGTGACCATGTTTCCTCTCAATAAAG (SEQ ID NO:209) >AF191770 GGCATCTGGCCCCTGGTAGCCAGCTCTCCAGAATTACTTGTAGGTAATTCCTCTCTTCAT (SEQ ID NO:210) >NM_006378 TGGATGTTTGTGCGCGTGT GTGGACAGT CTT AT CTT CCAGCAT GAT AG GATTT GACCATT (SEQ ID N0:211) >BC006819 TCCTGGCAGAGCCATGGTCCCAGGCTTCCCAAAAGTGTTTGTGGCAATTATTCCCCTAGG (SEQ ID NO:212) >X79676 TTTGATGATAGCAGACATTGTTACAAGGACATGGTGAGTCTATTTTTAATGCACCAATCT (SEQ ID NO:213) >BC006811 TTCTT CCAGTTGCACT ATT CT GAGGG AAAAT CT G ACACCT AAGAAATTT ACT GT GAAAAA (SEQ ID NO:214) >NM_000198 G AACAATTGTG GTCTCT CTT AACTT G AG GTTCT CTTTT GACT AATAGAGCT CCATTT CCC (SEQ ID NO:215) >AF301598 GTTAAGTGTGGCCAAGCGCACGGCGGCAAGTTTTCAAGCACTGAGTTTCTATTCCAAGAT (SEQ ID NO:216) >NM_002847 CG GCCT ACT GAGCG GACAG AAT GAT GCCAAAAT ATT GCTT AT GT CT CT ACAT GGT ATT GT (SEQ ID NO:217) >NM_004062 CAGGGTGTTTGCCCAATAATAAAGCCCCAGAGAACTGGGCTGGGCCCTATGGGATTGGTA(SEQ ID NO:218) >AW118445 TGTACAGTTTGGTTGTTGCTGTAAATATGGTAGCGTTTTGTTGTTGTTGTTTTTTCATGC (SEQ ID NO:219) >BC002551 TACCAAACTGGGACTCACAGCTTTATTGGGCTTTCTTTGTGTCTTGTGTGTTTCTTTTAT (SEQ ID NO:220) >AA765597 CATT GAG GTTTGGATGGTGG CAG GT AAAACAG AAAG G CAAG AT G T CAT CT G ACATT AG G C (SEQ ID NO:221) >AL 137761 AGTT CAGCACT GTGGTTAT CATT GGT GAT G CCAG AAAACATT AGTAGACTT AGACAATT G (SEQ ID NO:222) >X78202 TAAAATTTCTTGATTGTGACTATGTGGTCATATGCCCGTGTTTGTCACTTACAAAAATGT (SEQ ID NO:223) >AK025615 AGCCAT CT GGTGTGAAGAACT CT AT ATTTGTATGTT GAGAGGGCATGGAAT AATT GT ATT (SEQ ID NO:224) >BC001665 CTTATTGTCACTGGTTAAGAACTTGGCGAGATTGAAGGGCTTTTGTTATTGTTGTTGGAT (SEQ ID NO:225) >AI985118 CTTTCTAGTGAGCTAACCGTAACAGAGAGCCTACAGGATACACGTGAGATAATGTCACGT (SEQ ID NO:226) >AL039118 TTGTCTT AAAATTT CTT GATT GT GAT ACT GTGGT CAT ATGCCCGTGTTTGT CACTT ACAA (SEQ ID NO:227) >AA782845 CCTGGGGGAAAGGGGCATTCATGACCTGAACTTTTTAGCAAATTATTATTCTCAGTTTCC (SEQ ID NO:228) >BC016340 TTCATTAACAGTACTAAGTGGAAGGGATCTGCAGATTCCAAATTGGAATAAGCTCTATCA (SEQ ID NO:229) >AA745593 CCAATGCAGAAGAGTATTAAGAAAGATGCTCAAGTCCCATGGCACAGAGCAAGGCGGGCA (SEQ ID NO:230) >NM_004967 CAAGGCTACGATGGCTATGATGGTCAGAATTACTACCACCACCAGTGAAGCTCCAGCCTG (SEQ ID NO:231) >BF510316 AGCTCACAGCTGGACAGGTGTTGTATATAGAGTGGAATCTCTTGGATGCAGCTTCAAGAA (SEQ ID NO:232) >AA993639 TCCAAAGTAGAAAGGGTTCTTTTAGAAAACTTGAAGAATGTGCCTCCTCTTAGCATCTGT (SEQ ID NO:233) >AV656862 GATGCATTTTTCAGTCCCTTTTCAGAGCAAATGCTTTTGCAATGGTAGTAATGTTTAGTT (SEQ ID NO:234) >X69699 CCTGTGG GGCTTCTCT CCTT GAT G CTT CTTT CTTTTTTT AAAGACAACCT G CCATT ACCA (SEQ ID NO:235) >BC013282 TTG CACT AAGTCAT G CTGTTTCCT CAAAGAAG CTTT GTTTTTTGTT AACGTATT ACT CAG (SEQ ID NO:236) >AI457360 CTGGATCCCAGGCCCTGGCACCCCTCAGGAAATACAAGAAAAAGAATATTCACATCTGTT (SEQ ID NO:237) >AW445220 TTAGAGGGGCCACCTATCAACTCATCAGTGTTCAAAGAATATGCTGGGAGCATGGGTGAG (SEQ ID NO:238) >AF038191 G GCCCATTT ATGT CCCT CAT GTCT CTAGATTTT CT CGT CACCCAGCCT CAAAAAT AT AT G (SEQ ID NO:239) >X05615 T CCCCAAAAACCT CACCCGAGGCT G CCCACT ATGGT CAT CTTTTT CT CT AAAAT AGTT AC (SEQ ID NO:240) >BC005364 G AAATT CCT CACACCTT GCACCTT CCCTACTTTT CT GAATT GCT AT GACTACT CCTT GTT (SEQ ID NO:241) >AK025701 T GT CT GT CCACCACGAGATGGGAGGAGGAGAAAAAGCGGTACGAT GCCTTCCT GACCT CA (SEQ ID NO:242) >BF446419 GT CTT AT CT CT CAGGGGGGGTTT AAGT GCCGTTT GCAAT AAT GT CGT CTT ATTT ATTTAG (SEQ ID NO:243) >AK025470 CCG AGT AGT ATGGGT CT CT GT GT GAGAAACCAGGAGATATTTT CAT CTT GTT CGGAAAT A (SEQ ID NO:244) >BE552004 TTGTGCAAAAGTCCCACAACCTTTCTGGATTGATAGTTTGTGGTGAAATAAACAATTTTA (SEQ ID NO:245) >H05388 T CCAGT ATT CT GCAGGGCCAGT CAGTT GT ACAGAAGTT GGAATATT CT GTT CCAGAATT A (SEQ ID NO:246) >NM_033229 GT CT CGAACAGCGGTT GTTTTT ACTTTATTTAT CTTAGGCCCT CAGCTCCCT GACGT CCT (SEQ ID NO:247) >BC010437 AGTGAATCTTTTCCTCTTGGTAGCATCAACACTGGGGATAAATCAGAACCATTCTGTGGA (SEQ ID NO:248) >AI952953 TGAGAGCCCAGAACAAGAAGGAGCAGAAGGGCACTTTGACCTTCATTATTATGAAAATCA (SEQ ID NO:249) >R45389 GGAAGAACTGATGCTTGCTGCTAACTAAAGTTTTGGATGTATCGATTTAGAGAACCAATT (SEQ ID NO:250) >NM_001337 GAAT G AG AG AAT AAGT CAT GTTCCTT CAAGAT CATGTACCCCAATTT ACTTGCCATT ACT (SEQ ID NO:251) >AI499593 T ACGGAAAGGAAACAGGTT ATACT CTT AGATTT AAAAAGT GAAAGAAACTGCAGGCGCCT (SEQ ID NO:252) [0077] In some embodiments of the invention, the expression levels of gene sequences is measured by detection of expressed sequences in a cell containing sample as hybridizing to the above oligonucleotides, vtfiich correspond to sequences in the Sequence Listing as indicated by the accession numbers provided.

[0078] In additional embodiments, the invention provides for use of any number of the gene sequences of the set of 74 or the set of 90 in the methods of the invention. Thus anywhere from 1 to all of the 50 or more gene sequences used in the invention may be from either or both of the above sets. So from one, two, three, four, five, six, seven, eight, nine, ten, or more of the 50 or more sequences may be from the set of 74 or the set of 90.

[0079] As used herein, a "tumor sample" or "tumor containing sample" or "tumor cell containing sample" or variations thereof, refer to cell containing samples of tissue or fluid isolated from an individual suspected of being afflicted with, or at risk of developing, cancer. The samples may contain tumor cells which may be isolated by known methods or other appropriate methods as deemed desirable by the skilled practitioner. These include, but are not limited to, microdissection, laser capture microdissection (LCM), or laser microdissection (LMD) before use in the instant invention. Alternatively, undissected cells within a "section" of tissue may be used. Non-limiting examples of such samples include primary isolates (in contrast to cultured cells) and may be collected by any non-invasive or minimally invasive means, including, but not limited to, ductal lavage, fine needle aspiration, needle biopsy, the devices and methods described in U.S. Patent 6,328,709, or any other suitable means recognized in the art. Alternatively, the sample may be collected by an invasive method, including, but not limited to, surgical biopsy.

[0080] The detection and measurement of transcribed sequences may be accomplished by a variety of means known in the art or as deemed appropriate by the skilled practitioner. Essentially, any assay method may be used as long as the assay reflects, quantitatively or qualitatively, expression of the transcribed sequence being detected.

[0081] The ability to classify tumor samples is provided by the recognition of the relevance of the level of expression of the gene sequences (whether randomly selected or specified) and not by the form of the assay used to determine the actual level of expression. An assay of the invention may utilize any identifying feature of a individual gene sequence as disclosed herein as long as the assay reflects, quantitatively or qualitatively, expression of the gene in the "transcriptome" (the transcribed fraction of genes in a genome) or the "proteome" (the translated fraction of expressed genes in a genome). Additional assays include those based on the detection of polypeptide fragments of the relevant member or members of the proteome. Non-limiting examples of the latter include detection of proteolytic fragments found in a biological fluid, such as blood or serum. Identifying features include, but are not limited to, unique nucleic acid sequences used to encode (DNA), or express (RNA), said gene or epitopes specific to, or activities of, a protein encoded by a gene sequence.

[0082] Additional means include detection of nucleic acid amplification as indicative of increased expression levels and nucleic acid inactivation, deletion, or methylation, as indicative of decreased expression levels. Stated differently, the invention may be practiced by assaying one or more aspect of the DNA template(s) underlying the expression of each gene sequence, of the RNA used as an intermediate to express the sequence, or of the proteinaceous product expressed by the sequence, as well as proteolytic fragments of such products. As such, the detection of the presence of, amount of, stability of, or degradation (including rate) of, such DNA, RNA and proteinaceous molecules may be used in the practice of the invention.

[0083] In some embodiments, all or part of a gene sequence may be amplified and detected by methods such as the polymerase chain reaction (PCR) and variations thereof, such as, but not limited to, quantitative PCR (Q-PCR), reverse transcription PCR (RT-PCR), and real-time PCR (including as a means of measuring the initial amounts of mRNA copies for each sequence in a sample), optionally real-time RT-PCR or real-time Q-PCR. Such methods would utilize one or two primers that are complementary to portions of a gene sequence, where the primers are used to prime nucleic acid synthesis. The newly synthesized nucleic acids are optionally labeled and may be detected directly or by hybridization to a polynucleotide of the invention. The newly synthesized nucleic acids may be contacted with polynucleotides (containing gene sequences) of the invention under conditions which allow for their hybridization. Additional methods to detect the expression of expressed nucleic acids include RNAse protection assays, including liquid phase hybridizations, and in situ hybridization of cells.

[0084] Alternatively, the expression of gene sequences in FFPE samples may be detected as disclosed in U.S. applications 60/504,087, filed September 19, 2003, 10/727,100, filed December 2, 2003, and 10/773,761, filed February 6, 2004 (all three of which are hereby incorporated by reference as if fully set forth). Briefly, the expression of all or part of an expressed gene sequence or transcript may be detected by use of hybridization mediated detection (such as, but not limited to, microarray, bead, or particle based technology) or quantitative PCR mediated detection (such as, but not limited to, real time PCR and reverse transcriptase PCR) as non-limiting examples. The expression of all or part of an expressed polypeptide may be detected by use of immunohistochemistry techniques or other antibody mediated detection (such as, but not limited to, use of labeled antibodies that bind specifically to at least part of the polypeptide relative to other polypeptides) as non-limiting examples. Additional means for analysis of gene expression are available, including detection of expression within an assay for global, or near global, gene expression in a sample (e.g. as part of a gene expression profiling analysis such as on a microarray). Non-limiting examples linear RNA amplification and those described in U.S. Patent Application 10/062,857 (filed on October 25, 2001), as well as U.S. Provisional Patent Applications 60/298,847 (filed June 15, 2001) and 60/257,801 (filed December 22, 2000), all of which are hereby incorporated by reference in their entireties as if fully set forth.

[0085] In embodiments using a nucleic acid based assay to determine expression includes immobilization of one or more gene sequences on a solid support, including, but not limited to, a solid substrate as an array or to beads or bead based technology as known in the art. Alternatively, solution based expression assays known in the art may also be used. The immobilized gene sequence(s) may be in the form of polynucleotides that are unique or otherwise specific to the gene(s) such that the polynucleotides would be capable of hybridizing to the DNAor RNA of said gene(s). These polynucleotides may be the full length of the gene(s) or be short sequences of the genes (up to one nucleotide shorter than the full length sequence known in the art by deletion from the 5' or 3' end of the sequence) that are optionally minimally interrupted (such as by mismatches or inserted non-complementary basepairs) such that hybridization with a DNA or RNA corresponding to the genes is not affected. In some embodiments, the polynucleotides used are from the 3' end of the gene, such as within about 350, about 300, about 250, about 200, about 150, about 100, or about 50 nucleotides from the polyadenylation signal or polyadenylation site of a gene or expressed sequence. Polynucleotides containing mutations relative to the sequences of the disclosed genes may also be used so long as the presence of the mutations still allows hybridization to produce a detectable signal. Thus the practice of the present invention is unaffected by the presence of minor mismatches between the disclosed sequences and those expressed by cells of a subject's sample. A non-limiting example of the existence of such mismatches are seen in cases of sequence polymorphisms between individuals of a species, such as individual human patients within Homo sapiens.

[0086] As will be appreciated by those skilled in the art, some gene sequences include 3' poly A (or poly T on the complementary strand) stretches that do not contribute to the uniqueness of the disclosed sequences. The invention may thus be practiced with gene sequences lacking the 3' poly A (or poly T) stretches. The uniqueness of the disclosed sequences refers to the portions or entireties of the sequences which are found only in nucleic acids, including unique sequences found at the 3' untranslated portion thereof. Some unique sequences for the practice of the invention are those which contribute to the consensus sequences for the genes such that the unique sequences will be useful in detecting expression in a variety of individuals rather than being specific for a polymorphism present in some individuals. Alternatively, sequences unique to an individual or a subpopulation may be used. The unique sequences may be the lengths of polynucleotides of the invention as described herein.

[0087] In additional embodiments of the invention, polynucleotides having sequences present in the 3' untranslated and/or noncoding regions of gene sequences are used to detect expression levels in cell containing samples of the invention. Such polynucleotides may optionally contain sequences found in the 3' portions of the coding regions of gene sequences. Polynucleotides containing a combination of sequences from the coding and 3' non-coding regions preferably have the sequences arranged contiguously, with no intervening heterologous sequence(s).

[0088] Alternatively, the invention may be practiced with polynucleotides having sequences present in the 5' untranslated and/or non-coding regions of gene sequences to detect the level of expression in cells and samples of the invention. Such polynucleotides may optionally contain sequences found in the 5' portions of the coding regions. Polynucleotides containing a combination of sequences from the coding and 5' non-coding regions may have the sequences arranged contiguously, with no intervening heterologous sequence(s). The invention may also be practiced with sequences present in the coding regions of gene sequences.

[0089] The polynucleotides of some embodiments contain sequences from 3' or 5' untranslated and/or non-coding regions of at least about 16, at least about 18, at least about 20, at least about 22, at least about 24, at least about 26, at least about 28, at least about 30, at least about 32, at least about 34, at least about 36, at least about 38, at least about 40, at least about 42, at least about 44, or at least about 46 consecutive nucleotides. The term "about” as used in the previous sentence refers to an increase or decrease of 1 from the stated numerical value. Other embodiments use polynucleotides containing sequences of at least or about 50, at least or about 100, at least about or 150, at least or about 200, at least or about 250, at least or about 300, at least or about 350, or at least or about 400 consecutive nucleotides. The term "about" as used in the preceding sentence refers to an increase or decrease of 10% from the stated numerical value.

[0090] Sequences from the 3' or 5' end of gene coding regions as found in polynucleotides of the invention are of the same lengths as those described above, except that they would naturally be limited by the length of the coding region. The 3' end of a coding region may include sequences up to the 3' half of the coding region. Conversely, the 5' end of a coding region may include sequences up the 5' half of the coding region. Of course the above described sequences, or the coding regions and polynucleotides containing portions thereof, may be used in their entireties.

[0091] In another embodiment of the invention, polynucleotides containing deletions of nucleotides from the 5' and/or 3' end of gene sequences may be used. The deletions are preferably of 1-5, 5-10, 10-15, 15-20, 20-25, 25-30, 30-35, 35-40, 40-45, 45-50, 50-60, 60-70, 70-80, 80-90, 90-100, 100-125, 125-150, 150-175, or 175-200 nucleotides from the 5' and/or 3' end, although the extent of the deletions would naturally be limited by the length of the sequences and the need to be able to use the polynucleotides for the detection of expression levels.

[0092] Other polynucleotides of the invention from the 3' end of gene sequences include those of primers and optional probes for quantitative PCR. Preferably, the primers and probes are those which amplify a region less than about 750, less than about 700, less than about 650, less than about 6000, less than about 550, less than about 500, less than about 450, less than about 400, less than about 350, less than about 300, less than about 250, less than about 200, less than about 150, less than about 100, or less than about 50 nucleotides from the from the polyadenylation signal or polyadenylation site of a gene or expressed sequence. The size of a PCRamplicon of the invention may be of any size, including at least or about 50, at least or about 100, at least about or 150, at least or about 200, at least or about 250, at least or about 300, at least or about 350, or at least or about 400 consecutive nucleotides, all with inclusion of the portion complementary to the PCR primers used.

[0093] Other polynucleotides for use in the practice of the invention include those that have sufficient homology to gene sequences to detect their expression by use of hybridization techniques. Such polynucleotides preferably have about or 95%, about or 96%, about or 97%, about or 98%, or about or 99% identity with the gene sequences to be used. Identity is determined using the BLAST algorithm, as described above. The other polynucleotides for use in the practice of the invention may also be described on the basis of the ability to hybridize to polynucleotides of the invention under stringent conditions of about 30% v/v to about 50% formamide and from about 0.01M to about 0.15M salt for hybridization and from about 0.01M to about 0.15M salt for wash conditions at about 55 to about 65°C or higher, or conditions equivalent thereto.

[0094] In a further embodiment of the invention, a population of single stranded nucleic acid molecules comprising one or both strands of a human gene sequence is provided as a probe such that at least a portion of said population may be hybridized to one or both strands of a nucleic acid molecule quantitatively amplified from RNA of a cell or sample of the invention. The population may be only the antisense strand of a human gene sequence such that a sense strand of a molecule from, or amplified from, a cell may be hybridized to a portion of said population. The population preferably comprises a sufficiently excess amount of said one or both strands of a human gene sequence in comparison to the amount of expressed (or amplified) nucleic acid molecules containing a complementary gene sequence.

[0095] The invention further provides a method of classifying a human tumor sample by detecting the expression levels of 50 or more transcribed sequences in a nucleic acid or cell containing sample obtained from a human subject, and classifying the sample as containing a tumor cell of a tumor type found in humans to the exclusion of one or more other human tumor types. In some embodiments, the method may be used to classify a sample as being, or having cells of, one of the 53 tumor types listed above to the exclusion of one or more of the other 52. In other embodiments, the method is used to classify a sample as being, or having cells of, one of the 34 tumor types listed above to the exclusion of one or more of the other 33 tumor types. In further embodiments, the method is used to classify a sample as being, or having cells of, one of the 39 tumor types listed above to the exclusion of one or more of the other 38 tumor types.

[0096] The invention also provides a method for classifying tumor samples as being one of a subset of the possible tumor types described herein by detecting the expression levels of 50 or more transcribed sequences in a nucleic acid containing tumor sample obtained from a human subject, and classifying the sample as being one of a number of tumor types found in humans to the exclusion of one or more other human tumor types. In some embodiments of the invention, the number of other tumor types is from 1 to about 3, more preferably from 1 to about 5, from 1 to about 7, or from 1 to about 9 or about 10. In other embodiments, the number of tumor types are all of the same tissue or organ origin such as those listed above. This aspect of the invention is related to the above discussion of Figure 8 and of trading off specificity in favor of increased confidence, and may be advantageously applied to situations where the classification of a sample as a single tumor type is at a level of accuracy or performance that can be improved by classifying the sample as one of a subset of possible tumor types.

[0097] In additional embodiments, the invention may be practiced by analyzing gene expression from single cells or homogenous cell populations which have been dissected away from, or otherwise isolated or purified from, contaminating cells of a sample as present in a simple biopsy. One advantage provided by these embodiments is that contaminating, non-tumor cells (such as infiltrating lymphocytes or other immune system cells) may be removed as so be absent from affecting the genes identified or the subsequent analysis of gene expression levels as provided herein. Such contamination is present where a biopsy is used to generate gene expression profiles.

[0098] In further embodiments of the invention utilizing Q-PCR or reverse transcriptase Q-PCR as the assay platform, the expression levels of gene sequences of the invention may be compared to expression levels of reference genes in the same sample or a ratio of expression levels may be used. This provides a means to "normalize" the expression data for comparison of data on a plurality of known tumor types and a cell containing sample to be assayed. While a variety of reference genes may be used, the invention may also be practiced with the use of 8 particular reference gene sequences that were identified for use with the set of 39 tumor types. Moreover, the Q-PCR may be performed in whole or in part with use of a multiplex format.

[0099] mRNA sequences corresponding to the 8 reference sequences are provided in the attached Sequence Listing. A listing of the corresponding SEQ ID NOs, with corresponding identifying information, including accession numbers and other information, is provided by the following. >Hs.77031_mRNA_1 gi|16741772|gb|BC016680.1 |BC016680 Homo sapiens clone MGC:21349 IMAGE4338754 polyA=3 (SEQ ID NO:253) >Hs.77541_mRNA_1 gi|12804364|gb|BC003043.1|BC003043 Homo sapiens clone MGC:4370 IMAGE:2822973 polyA=3 (SEQ ID NO:254) >Hs.7001_mRNA_1 gi|6808256|emb|AL137727.1|HSM802274 Homo sapiens mRNA; cDNA DKFZp434M0519 (from clone DKFZp434M0519); partial cds polyA=3 (SEQ ID NO.255) >Hs.302144_mRNA_1 gi|11493400|gb|AF130047.1 |AF130047 Homo sapiens clone FLB3020 polyA=0 (SEQ ID NO:256) >Hs.26510_mRNA_2 gi|11345385|gb|AF308803.1|AF308803 Homo sapiens chromosome 15 map 15q26 polyA=3 (SEQ ID NO:257)

>Hs.324709_mRNA_2 gi|12655026|gb|BC001361.1 |BC001361 Homo sapiens clone MGC:2474 IMAGE3050694 polyA=2 (SEQ ID NO:258)

>Hs.65756_mRNA_3 gi|3641494|gb|AF035154.1|AF035154 Homo sapiens chromosome 16 map 16p13.3 polyA=3 (SEQ ID NO:259)

>Hs. 165743_mRNA_2 gi|13543889|gb|BC006091.1|BC006091 Homo sapiens clone MGC:12673 IMAGE:3677524 polyA=3 (SEQ ID NO:260) [0100] Detection of expression of any of the above reference sequences may be by the same or different methodology as for the other gene sequences described above. In some embodiments of the invention, the expression levels of gene sequences is measured by detection of expressed sequences in a cell containing sample as hybridizing to the following oligonucleotides, which correspond to the above sequences as indicated by the accession numbers provided. >BC006091 TCATCTTCACCAAACCAGTCCGAGGGGTCGAAGCCAGACACGAGAGGAAGAGGGTCCTGG (SEQ ID NO:261) >BC003043 CTCTGCTCCTGCTCCTGCCTGCATGTTCTCTCTGTTGTTGGAGCCTGGAGCCTTGCTCTC (SEQ ID NO:262) >AF130047 TGCTCCCGG CTGTCCTCCTCTCCT CTT CCCTAGT GAGT GGTT AAT GAGT GTT AAT GCCT A (SEQ ID NO:263) >AF035154 CCCCATCT CT AAAACCAGT AAAT CAG CCAG CGAATACCCGGAAGCAAG ATGCACAGGCGG (SEQ ID NO : 264) >BC001361 CCAGAAACAAGGAAGAGGAAAGACAAAGGGAAGGGACGGGAGCCCTGGAGAAGCCCGACC (SEQ ID NO : 265) >AF308803 AAGTACAACCCATGCTGCTAAGATGCGAGCAGGAAGAGGCATCCTTTGOTAAATCCTGTT (SEQ ID NO:266) >BC016680 ACCTCACCCCTGCCCGGCCCAAGCTCTACTTGTGTACAGTGTATATTGTATAATAGACAA (SEQ ID NO:267) >AL137727 TT CCCTT AATT CCT CCT CCCGACCTTTTTT ACCCCCCCAGTTGCAGT ATTT AACT GGGCT (SEQ ID NO:268) [0101] In an additional aspect, the methods provided by the present invention may also be automated in whole or in part. This includes the embodiment of the invention in software. Non-limiting examples include processor executable instructions on one or more computer readable storage devices wherein said instructions direct the classification of tumor samples based upon gene expression levels as described herein. Additional processor executable instructions on one or more computer readable storage devices are contemplated wherein said instructions cause representation and/or manipulation, via a computer output device, of the process or results of a classification method.

[0102] The invention includes software and hardware embodiments wherein the gene expression data of a set of gene sequences in a plurality of known tumor types is embodied as a data set. In some embodiments, the gene expression data set is used for the practice of a method of the invention. The invention also provides computer related means and systems for performing the methods disclosed herein. In some embodiments, an apparatus for classifying a cell containing sample is provided. Such an apparatus may comprise a query input configured to receive a query storage configured to store a gene expression data set, as described herein, received from a query input; and a module for accessing and using data from the storage in a classification algorithm as described herein. The apparatus may further comprise a string storage for the results of the classification algorithm, optionally with a module for accessing and using data from the string storage in an output algorithm as described herein.

[0103] The steps of a method, process, or algorithm described in connection with the embodiments disclosed herein may be embodied directly in hardware, in a software module executed by a processor, or in a combination of the two. The various steps or acts in a method or process may be performed in the order shown, or may be performed in another order. Additionally, one or more process or method steps may be omitted or one or more process or method steps may be added to the methods and processes. An additional step, block, or action may be added in the beginning, end, or intervening existing elements of the methods and processes.

[0104] A further aspect of the invention provides for the use of the present invention in relation to clinical activities. In some embodiments, the determination or measurement of gene expression as described herein is performed as part of providing medical care to a patient, including the providing of diagnostic services in support of providing medical care. Thus the invention includes a method in the medical care of a patient, the method comprising determining or measuring expression levels of gene sequences in a cell containing sample obtained from a patient as described herein. The method may further comprise the classifying of the sample, based on the determination/measurement, as including a tumor cell of a tumor type or tissue origin in a manner as described herein. The determination and/or classification may be for use in relation to any aspect or embodiment of the invention as described herein.

[0105] The determination or measurement of expression levels may be preceded by a variety of related actions. In some embodiments, the measurement is preceded by a determination or diagnosis of a human subject as in need of said measurement. The measurement may be preceded by a determination of a need for the measurement, such as that by a medical doctor, nurse or other health care provider or professional, or those working under their instruction, or personnel of a health insurance or maintenance organization in approving the performance of the measurement as a basis to request reimbursement or payment for the performance.

[0106] The measurement may also be preceded by preparatory acts necessary to the actual measuring. Non-limiting examples include the actual obtaining of a cell containing sample from a human subject; or receipt of a cell containing sample; or sectioning a cell containing sample; or isolating cells from a cell containing sample; or obtaining RNAfrom cells of a cell containing sample; or reverse transcribing RNAfrom cells of a cell containing sample. The sample may be any as described herein for the practice of the invention.

[0107] In additional embodiments, the invention provides for a method of ordering, or receiving an order for, the performance of a method in the medical care of a patient or other method of the invention. The ordering may be made by a medical doctor, a nurse, or other health care provider, or those working under their instruction, while the receiving, directly or indirectly, may be made by any person wfro performs the method(s). The ordering may be by any means of communication, including communication that is written, oral, electronic, digital, analog, telephonic, in person, by facsimile, by mail, or otherwise passes through a jurisdiction within the United States.

[0108] The invention further provides methods in the processing of reimbursement or payment for a test, such as the above method in the medical care of a patient or other method of the invention. A method in the processing of reimbursement or payment may comprise indicating that 1) payment has been received, or 2) payment vull be made by another payer, or 3) payment remains unpaid on paper or in a database after performance of an expression level detection, determination or measurement method of the invention. The database may be in any form, with electronic forms such as a computer implemented database included within the scope of the invention. The indicating may be in the form of a code on paper or in the database. The "another payer" may be any person or entity beyond that to whom a previous request for reimbursement or payment was made.

[0109] Alternative, the method may comprise receiving reimbursement or payment for the technical or actual performance of the above method in the medical care of a patient; for the interpretation of the results from said method; or for any other method of the invention. Of course the invention also includes embodiments comprising instructing another person or party to receive the reimbursement or payment. The ordering may be by any communication means, including those described above. The receipt may be from any entity, including an insurance company, health maintenance organization, governmental health agency, or a patient as non-limiting examples. The payment may be in whole or in part. In the case of a patient, the payment may be in the form of a partial payment known as a co-pay.

[0110] In yet another embodiment, the method may comprise forwarding or having forwarded a reimbursement or payment request to an insurance company, health maintenance organization, governmental health agency, or to a patient for the performance of the above method in the medical care of a patient or other method of the invention. The request may be by any communication means, including those described above.

[0111] In a further embodiment, the method may comprise receiving indication of approval for payment, or denial of payment, for performance of the above method in the medical care of a patient or other method of the invention. Such an indication may come from any person or party to whom a request for reimbursement or payment was made. Non-limiting examples include an insurance company, health maintenance organization, or a governmental health agency, like Medicare or Medicaid as non-limiting examples. The indication may be by any communication means, including those described above.

[0112] An additional embodiment is where the method comprises sending a request for reimbursement for performance of the above method in the medical care of a patient or other method of the invention. Such a request may be made by any communication means, including those described above. The request may have been made to an insurance company, health maintenance organization, federal health agency, or the patient for whom the method was performed.

[0113] A further method comprises indicating the need for reimbursement or payment on a form or into a database for performance of the above method in the medical care of a patient or other method of the invention. Alternatively, the method may simply indicate the performance of the method. The database may be in any form, with electronic forms such as a computer implemented database included within the scope of the invention. The indicating may be in the form of a code on paper or in the database.

[0114] In the above methods in the medical care of a patient or other method of the invention, the method may comprise reporting the results of the method, optionally to a health care facility, a health care provider or professional, a doctor, a nurse, or personnel working therefor. The reporting may also be directly or indirectly to the patient. The reporting may be by any means of communication, including those described above.

[0115] The invention further provides kits for the determination or measurement of gene expression levels in a cell containing sample as described herein. A kit will typically comprise one or more reagents to detect gene expression as described herein for the practice of the present invention. Non-limiting examples include polynucleotide probes or primers for the detection of expression levels, one or more enzymes used in the methods of the invention, and one or more tubes for use in the practice of the invention. In some embodiments, the kit will include an array, or solid media capable of being assembled into an array, for the detection of gene expression as described herein. In other embodiments, the kit may comprise one or more antibodies that is immunoreactive with epitopes present on a polypeptide which indicates expression of a gene sequence. In some embodiments, the antibody will be an antibody fragment.

[0116] A kit of the invention may also include instructional materials disclosing or describing the use of the kit or a primer or probe of the present invention in a method of the invention as provided herein. A kit may also include additional components to facilitate the particular application for which the kit is designed. Thus, for example, a kit may additionally contain means of detecting the label (e.g. enzyme substrates for enzymatic labels, filter sets to detect fluorescent labels, appropriate secondary labels such as a sheep anti-mouse-HRP, or the like). A kit may additionally include buffers and other reagents recognized for use in a method of the invention.

[0117] Having now generally described the invention, the same will be more readily understood through reference to the following examples which are provided by way of illustration, and are not intended to be limiting of the present invention, unless specified.

EXAMPLES

Example 1: Materials and methods [0118] The following table shows the types and number of samples of known tumors used in Example 2.

[0119] The 500 samples were fresh or frozen samples of tumor containing tissue. The 468 samples shown above were used for further experiments by taking 374 as the training set and the remaining 94 samples as the testing set. Tumor types of fewer than 5 samples were not used initially.

[0120] The samples contained both primary and metastatic tumors with a confirmed diagnosis. A single 5pm section was stained (H+E), and the tumor visualized. Pure tumor populations were obtained by either manual dissection, or laser capture microdissection (Arcturus, Mountain View, CA).

[0121] RNA extraction and quality control were performed on each sample. Briefly, samples were processed using a silica spin column-based extraction method (Arcturus, Mountain View, CA). The total quantity of RNA extracted was assessed using quantitative PCR (Taqman, ABI), with primers specific for β-actin transcription. Only samples with greater than 10ng of RNA were amplified.

[0122] Samples were amplified using a modified RNA polymerase 2-round amplification protocol (Arcturus, Mountain View, CA). Following amplification, the RNA product yield was quantitated by OD(260/280) spectroscopy, and the amplified product visualized by agarose (2%) denaturing gel electrophoresis.

[0123] The amplified product from each sample was then hybridized to a microarray to detect the level of transcript expression in the samples. Random gene selection was performed using random sampling function software. For each number of genes selected, random samples were selected 100 times and used to compute the cross-validation and predictive accuracies on both training and testing sets. Cross-validation was by dividing the training set into parts with one being used to train and another being used as a test.

Example 2: Results [0124] The mean of the accuracies from 100 samplings and the 95% confidence interval were calculated and plotted for each step from 50 to 16948 genes. The plots showed the cross-validation and predictive accuracies from KNN (k-nearest neighbor) algorithm versus the number of genes selected by chance. Random gene selection used random sampling function in R software.

[0125] 50 or more genes were capable of accurately classifying among the numerous tumor types in toto with a better than 50% accuracy. Similar results are observed with the use of the samples and KNN with known FFPE tumor specimens from which RNA was extracted and analyzed for gene expression.

[0126] It should be noted that while the accuracy stabilized with the use of additional genes, it is expected that there are particular sets of 50 or more genes that have significantly higher accuracies. Classification of additional tumor types, such as those totaling 32 samples in the table above, may be made with the inclusion of additional samples.

[0127] The accuracy level of a set of 100 randomly selected expressed gene sequences was determined to be 66% and was used as described in Example 3 to generate Figures 1 and 2.

Example 3: Information capacity of random gene sets [0128] Subsets of the 100 randomly selected expressed gene sequences used to classify among 39 tumor types were tested for their ability to classify among subsets of the 39 tumor types. The expression levels of random combinations of 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 and all 100 (each combination sampled 10 times) of the 100 expressed sequences were used with data from tumor types and then used to predict test random sets of tumor samples (each sampled 10 times) ranging from 2 to all 39 types. Figure 1 shows the classification capability of various gene sets are shown relative to the number of tumor types classified. As expected, a higher number of gene sequences are needed to classify tumor types with higher accuracies. Figure 2 shows the classification performance for various numbers of tumor types relative to the number of gene sequences used.

[0129] The GenBank accession numbers of the 100 gene sequences are AF269223, BC006286, AK025501, AJ002367, AI469140, AW013883, NM_001238, AI476350, BC006546, AI041212, BF724944, AI376951, R56211, BC006393, X13274, BC001133, N62397, BC000885, AK001588, AK057901, AF146760, AI951287, AK025604, BC007581, BC015025, R43102, AW449550, AI922539, AI684144, AI277662, BC015999, AW444656, BC011612, BC015401, BF447279, BC009956, AL050163, BC001248, BE672684, AL137353, BC001340, U45975, BE856598, BC009060, AL137728, AA713797, AL583913, AK054617, AI028262, AI753041, BG939593, AL080179, AA814915, AF131798, AI961568, BC009849, AK021603, BC012561, AI570494, BC006973, AW294857, BC004952, AK026535, AI923614, AW082090, AI005513, AF339768, AK023167, AF169693, AF076249, BC007662, BC015520, AI814187, AI565381, AW271626, AK024120, AF139065, BC014075, AI887245, AF257081, AI767898, AF070634, AF155132, X69804, U65579, NM_004933, AI655104, AW131780, AI650407, AF131774, AA814057, AJ311123, BC009702, AF264036, AL161961, AJ010857, AF106912, AK023542, AF073518, and D83032. They were indexed from 1 to 100, and representative, and non-limiting, random sets used in the invention are as follows: [0130] For 50-genes, set 1, genes 9, 52, 55, 24,44, 58, 20, 79,81,86, 22, 84,27,32, 73, 70, 18,41, 54,38,46, 78,87,49, 15, 95, 12, 23, 30, 13, 36, 98, 28, 56, 21, 19, 35, 51,25, 43, 99, 34,64,66, 82, 72, 11, 92, 59, and 71 were used. In set 2, genes 72, 92, 27, 8, 14, 87, 42, 83, 65, 85, 40, 21,74, 66, 6, 28, 13, 98, 91, 78, 49, 52, 33, 30, 97, 84, 2, 95, 88, 64, 93, 11, 1,45, 61, 39, 12, 67, 53, 89, 43, 17, 54, 7, 55, 38, 3, 15, 70, and 31 were used. In set 3, genes 9, 35, 87, 52, 73, 74, 88, 22, 41,28, 93, 15, 67, 20, 68, 17, 46, 43, 51, 24, 84, 79, 19, 100, 76, 6, 49, 97, 16, 59, 89, 66, 45, 63, 2, 27, 13, 98, 69, 60, 26, 86, 83, 58, 71, 54, 82, 32, 42, and 77 were used. In set 4, genes 34, 67, 48, 53, 24, 61, 6, 64, 89, 76, 35 ,21, 86, 83, 68, 7, 25, 65, 58, 28, 97, 90, 31, 57, 3, 50, 2, 96, 84, 29,42, 46, 82, 62, 19, 95, 44, 52, 33, 36, 15, 37, 70, 11,43, 13, 8, 49, 16, and 99 were used. In set 5, genes 11,22, 87, 25, 5, 38, 35, 68, 94, 51, 60, 53, 20,42, 95, 92, 33, 15, 14, 24, 85, 37, 69, 17, 19, 93, 8, 97, 46,83,26,86, 66, 89,63, 16, 74, 28, 52, 2, 96, 99, 71, 10, 65, 90, 29, 34, 77, and 45 were used. In set 6, genes 62, 6, 69, 12, 19, 50, 51, 5, 1,32, 41, 84, 27, 10, 93, 28, 79, 21, 88, 47, 58, 64, 74, 39, 33, 46, 17, 86, 87, 4, 60, 98, 97, 45, 26, 72, 40, 63, 30, 54, 52, 11, 15, 96, 14, 24, 73, 67, 59, and 38 were used. In set 7, genes 67,21, 62, 15, 59, 6, 23, 30, 89, 94, 82, 74, 96, 17, 41, 38, 48, 100, 5, 71, 20, 55, 79, 28, 44, 64, 92, 65, S 1, 37, 32, 22, 72, 98, 12, 54, 78, 50, 60, 76, 88, 3, 40, 80, 77, 16, 24, 42, 8, and 14 were used. In set 8, genes 43, 68, 8, 38, 82, 73, 12, 23, 77, 63, 56, 33, 66, 14,47, 17, 53, 62, 42, 57, 30, 89,44, 58, 34, 24, 81,40, 45, 1, 99, 52, 37, 80, 96, 10, 71, 50, 20, 51, 18, 54, 31, 70, 84, 3, 83, 76, 59, and 91 were used. In set 9, genes 36, 90, 34, 79, 29, 24, 44, 51, 27, 58, 52, 37, 68, 49, 89, 80, 57, 8, 22, 77, 54, 65, 26, 91, 21, 64, 59, 61, 13, 74, 87, 50, 63, 20, 78, 23, 96, 67, 30, 55, 81,35, 72, 56, 95, 82, 39, 42, 88, and 92 were used. In set 10, genes 59, 94, 91, 88, 3, 45, 13, 96, 66, 58, 60, 69,21,95, 4, 7, 67, 83, 44, 2, 37, 24, 8, 12, 53,47, 34, 9, 31,46, 11, 68, 1, 6, 29, 14, 33, 54,43, 80, 39, 18, 100, 10, 84, 65, 5, 76, 26, and 22 were used.

[0131] For 55 genes, set 1, genes 20, 76, 33, 73, 15, 83, 47, 2, 95, 67, 26, 49, 97, 25, 46, 13, 51, 42, 14, 11, 39, 94, 37, 100, 56, 63, 6, 66, 45, 75, 3, 78, 55, 7, 72, 44, 35, 48, 65, 38, 60, 90, 30, 36, 77, 23, 16, 32, 80, 89, 8, 91,43, 50, and 28 were used. In set 2, genes 11, 63, 93, 79, 21, 57, 66, 10, 42, 83, 75, 94, 3, 38, 49, 91, 53, 90, 50, 52, 39, 99, 85, 48, 31, 18, 89, 25, 87, 56, 40, 5, 19, 88, 27, 92, 20, 100, 59, 43, 95, 80, 86, 44, 55, 68, 54, 33, 96, 45, 2, 9, 81, 73, and 37 were used. In set 3, genes 20, 73, 76, 29, 44, 33, 84, 98, 15, 69, 32, 14, 50, 70, 63, 41, 87, 74, 99, 34, 23, 36, 37, 68, 89, 43, 91, 18, 26, 45, 9, 90, 28, 92, 7, 30, 22, 54, 96, 72, 16, 38, 58, 52, 56, 79, 57, 47, 83, 17, 49, 2, 80, 51, and 46 were used. In set 4, genes 90, 63, 60, 82, 81, 50, 25, 24, 56, 9, 8, 89, 70, 55, 15, 4, 35, 75, 77, 46, 87, 6, 49, 85, 98, 58, 28, 27, 64, 47, 99, 51,86, 21, 54, 80, 41, 74, 88, 14, 36, 2, 23, 32, 19, 30, 52, 84, 62, 37, 43, 53, 72, 39, and 92 were used. In set 5, genes 27, 43, 33, 84, 89, 31, 60, 97, 15, 45, 42, 73, 4, 6, 90, 61, 72, 56, 2, 38, 96, 74, 94, 14, 25, 77, 58, 86, 21, 32, 82, 3, 50, 17, 28, 48, 44, 7, 70, 20, 59, 83, 1, 71, 52, 95, 69, 54, 39.46, 63, 51, 57, 34, and 22 were used. In set 6, genes 96, 12, 94, 27, 11, 33, 25, 22, 26, 50, 60, 70, 68, 30, 82, 34, 17, 32, 29, 19, 87, 76, 81, 7, 55, 35, 45, 56, 31, 99, 5, 24, 54, 97, 21, 92, 98, 36, 88, 23, 58, 77, 14, 95, 9, 73, 84, 61, 2, 38, 83, 65, 42, 74, and 48 were used. In set 7, genes 52, 11, 79, 27, 23, 64, 96, 33, 75, 12, 34, 94, 26, 78, 67, 51, 57, 70, 28, 89, 9, 98, 62, 91,41, 65, 73, 74, 8, 16, 90, 37, 1, 10, 59, 81,63, 30, 80, 18, 15, 48, 36, 19, 84, 14, 45, 38, 97, 99, 3, 82, 54, 22, and 5 were used. In set 8, genes 83, 57, 6, 37, 44, 76, 5, 59, 74, 62, 72, 23, 93, 75, 32, 100, 98, 29, 30, 65, 21, 17, 78, 46, 13, 82, 14, 50, 66, 63, 90, 49, 54, 68, 60, 10, 87, 94, 58, 91,33, 31, 36, 8, 11, 92, 51,38, 43, 52, 7, 86, 89, 84, and 70 were used. In set 9, genes 29, 100, 79, 21,63, 12, 51, 2, 18, 77, 81, 33, 68, 69, 13, 23, 37, 39, 14, 3, 93, 36, 5, 35, 30,40, 28, 61,49, 71, 27, 99, 75, 96, 83, 97, 78, 54, 19, 89, 62, 38, 8, 53, 26, 43, 52, 25, 58, 9, 31,86, 65, 6, and 60 were used. In set 10, genes 7, 37, 22, 39, 41, 89, 57, 75, 6,23,47, 51,55, 93,49, 5, 15, 79,20, 11,42,87, 78, 33,68, 76, 94, 77, 62, 16, 31, 54,28, 99, 90, 61,25,21, 59, 73, 83, 95,30, 91,65, 24,4, 17, 10, 72, 63, 98, 34, 69, and 1 were used.

[0132] For 60 genes, set 1, genes 67, 60, 53, 20, 3, 9, 87 ,16, 1, 14, 96, 82, 79, 94, 35, 32, 44, 22, 17, 46, 59, 29, 40, 57, 68, 52 ,48, 31,34, 23, 91, 38, 92, 49, 51, 86, 88, 55, 50, 39, 83, 65, 11,42, 4, 63, 47, 73, 84, 75, 77, 18, 74, 100, 26, 5, 72, 10, 90, and 76 were used. In set 2, genes 62, 67, 70, 82, 8, 10, 26, 45, 98, 38, 76, 14, 72, 36, 89, 95, 86, 96, 18, 91, 75, 74, 7, 46, 16, 83, 65, 33, 29, 57, 32, 42, 34, 37, 80, 100, 99, 9, 2, 22, 64, 11,87, 35, 23, 55, 60, 61,81,49, 5, 58, 3, 40, 71,54, 85, 94, 66, and 20 were used. In set 3, genes 49, 10, 76, 94, 83, 90,42, 57, 38, 85, 29, 1, 60, 71, 65,30,64,23, 72,27, 70, 13, 100,43, 20,44, 4, 88, 79, 24, 84, 91, 87, 41, 21, 48, 54, 68, 16, 35, 6, 89, 2, 34, 96, 22, 99, 52, 28, 3, 15, 47, 7, 61, 63, 75, 19, 97, 56, and 39 were used. In set 4, genes 99, 94, 58, 51,46, 87, 77, 23, 9, 74, 52, 4, 47, 42, 5, 62, 48, 14, 35, 32, 75, 98, 95, 18, 67, 76, 50, 8, 1, 19, 22 ,72, 11,83, 82, 89, 12, 24, 90, 80, 92, 85, 26, 66, 38, 78, 79, 60, 49, 59, 25, 84, 36, 29,45, 55, 27, 70, 39, and 57 were used. In set 5, genes 39, 21, 70, 81,88, 30, 2, 57, 45, 5, 47, 93, 1, 34, 51,49, 3, 6, 65, 97, 41, 67, 95, 85, 98, 29, 82, 38, 17, 84, 72, 52, 20, 33, 53, 66, 7, 54, 25, 23, 80, 61, 76, 9, 14, 48, 26, 12, 32, 4, 64, 73, 56, 87, 59, 35, 31, 62, 13, and 15 were used. In set 6, genes 99, 80, 35, 87, 17, 27, 53, 43, 38, 45, 61, 34, 81,3, 16, 42, 24, 37, 19, 39, 59, 6, 28, 74, 32, 92, 18, 31,25, 66, 79, 41,51,97, 58, 7, 49, 70, 71, 33, 78, 85, 63, 72, 89, 15, 40, 29,46, 1,73, 68, 56, 54,47, 5, 65, 100,44, and 22 were used. In set 7, genes 15, 51,66, 47, 4, 82, 78, 71, 72, 75, 61, 10, 34, 18, 12, 55, 32, 80, 45, 14, 3, 62, 20, 74, 96, 48, 94, 88, 69, 64, 86, 9, 24, 41, 8, 28, 81, 13, 37, 87, 53, 44, 57, 43, 30, 38, 67, 5, 100, 91, 50, 2, 42, 77, 7, 83, 73, 99, 68, and 6 were used. In set 8, genes 41, 21, 20, 62, 50, 86, 13, 23, 94, 45, 80, 51,42, 52, 47, 76, 18, 72, 25, 8, 35, 58, 37, 32, 46, 71, 99, 33, 48, 77, 38, 19, 44, 66, 7, 53, 12, 10, 74, 96, 84, 28, 30, 15, 2, 81, 7, 26, 79, 88, 24, 49, 65, 17, 95, 63, 75, 11, 55, and 36 were used. In set 9, genes 14,40, 30,48, 37, 3, 28, 57, 58, 22, 70, 74, 91, 98,46, 76, 81,65, 54, 23, 11,34, 17, 53, 26, 67, 80,42, 86, 73, 25, 24, 9, 88, 38, 45, 13, 56, 83, 87, 31, 36, 43, 100, 35, 41, 16, 33, 61,6, 49, 63, 71, 64, 96, 8, 19, 39, 68, and 84 were used. In set 10, genes 97, 39, 83, 8, 35, 74, 13, 96, 20, 19, 69, 10, 81, 57, 65, 17, 12, 48, 86, 4, 94, 25, 92, 22, 55, 43, 34, 45, 73, 18, 31, 15, 2, 61,51, 91,89, 82, 68, 46, 24, 77, 27, 88, 72, 16, 37, 70, 29, 60, 80, 14, 23, 44, 49, 66, 62, 32, 28, and 98 were used.

[0133] For 65 genes, set 1, genes 68, 57, 82, 75, 62, 43, 41, 76, 59, 34, 78, 95, 32, 79, 88,46,4, 89, 96, 84, 66, 10, 31,23, 52, 16, 85, 98, 28, 25, 74, 69, 39, 63, 64, 58, 65, 30, 13, 19,40, 50,48, 6, 93, 2, 11, 51, 100, 26, 27, 24, 1,87, 91,38, 5, 21, 56, 35, 61, 17, 90, 94, and 83 were used. In set 2, genes 62, 33, 59, 65, 12, 97, 20, 99, 13, 64, 29, 23, 49, 35, 66, 74, 77, 46, 14, 11,81, 32,42, 34, 70, 17, 54,44, 24, 53, 3, 8, 71,47, 96, 80, 86, 40, 15, 37, 90, 67, 73, 50, 25, 51,36, 75, 72, 92, 93, 4, 84, 18, 76, 21, 38, 88, 68, 9, 60, 52, 45, 7, and 41 were used. In set 3, genes 12, 80, 56, 70, 50, 95, 15, 85, 93, 53, 45, 47, 10, 99, 32, 76, 67, 89, 83, 35, 91, 62, 6, 84, 23, 52, 65, 9, 37, 4, 51,42, 48, 49, 100, 21, 5, 43, 75, 92, 98, 36, 16, 27, 19, 22, 82, 73, 58, 63, 34, 74, 3, 71,87, 72, 81, 1,68, 46, 55, 88, 64, 11, and 33 were used. In set 4, genes 16, 41, 15,40, 19, 47, 77, 96, 5, 21,38, 84, 22, 27, 81.46, 74, 36, 8, 52, 98, 87, 91, 54, 86, 80, 25, 39, 75, 42, 10, 83, 51,90, 62, 78, 17, 9, 53, 68, 12, 100, 24, 89, 20, 58, 59, 11, 92, 32, 30, 95, 49, 55, 73, 82, 99, 70, 97, 13, 6, 93, 67, 29, and 45 were used. In set 5, genes 94, 3, 31,85, 51,80, 8, 55, 22, 93, 97, 49, 14, 81, 67, 76, 77, 75, 19, 59, 5, 72, 34, 62, 58, 43, 7, 44, 35, 98, 24, 74, 41, 73, 63, 13, 87, 56, 15, 42, 12, 91, 50, 37, 29,40, 53, 83, 2, 99, 100, 1, 10, 33, 16, 26, 9, 71,39, 11,46, 57, 66, 92, and 82 were used. In set 6, genes 86, 55, 15, 9, 13, 94, 33, 16, 14, 11,32, 59,88, 64, 90, 50,45, 82, 7,44,48, 98, 21, 51,62, 99, 75,25, 19,41, 24, 26, 17, 23, 6, 71,72,47,42, 2, 85, 22, 56, 81,78, 79, 43, 18, 100, 36, 34, 70, 39, 80, 66, 97, 58, 31,30, 57, 35, 96, 12, 29, and 10 were used. In set 7, genes 16, 50, 4, 18, 60, 65, 37, 94, 1, 88, 76, 71, 31,2, 53, 59, 19, 26, 28, 89, 87, 77, 63, 57, 92, 55, 20, 93, 72, 38, 46, 62, 45, 11, 52, 95, 54, 14, 36, 42, 39, 64, 7, 99, 86, 78, 27, 43, 66, 58, 25, 81, 79, 41,90, 13, 73, 67, 32, 44, 23, 34,29, 6, and 35 were used. In set 8, genes 8, 53,3,33,84,61, 74, 98,31, 9, 55, 62,4,88, 27, 50,85, 34,69,83, 99, 17, 25, 19,40, 90,45,30,28, 92, 93, 75, 95, 37, 6, 24, 79, 96, 70, 60, 91, 52, 89, 49, 10, 100, 39, 77, 41,23, 29, 20, 22, 5, 16, 59, 21,46, 80, 32, 73, 72, 2, 26, and 48 were used. In set 9, genes 98, 82, 24, 35, 25, 93, 5, 56, 76, 96, 2, 78, 40, 13, 83, 86, 92, 77, 81, 29, 5 8, 99, 97, 80, 18, 27, 1, 65, 14, 16, 59, 20, 26, 67, 32, 22, 90, 37, 85, 7, 41, 34, 4, 68, 45, 12, 79, 62, 17, 75, 84, 91, 54, 72, 57, 10, 95, 44, 52, 9, 28, 89, 100, 33, and 21 were used. In set 10, genes 96 ,40, 22, 50, 75, 38, 98, 89, 55, 60, 86, 18, 87, 85, 49, 2, 57, 73, 33, 29, 59, 42, 63, 68, 62, 92, 74, 53, 8, 7, 51, 71, 11, 30, 83, 56, 77, 81, 79, 16, 37, 69, 61, 64, 27, 67, 25, 100, 31, 3, 13, 4, 12, 21, 65, 99, 36, 66, 6, 94, 44, 35, 72, 95, and 90 were used.

[0134] For 70 genes, set 1, genes 36, 6, 100, 39, 37, 3, 27, 45, 93, 19, 89, 43, 68, 9, 60, 46, 51, 80, 32, 52, 62, 35, 58, 14, 10, 33, 85, 12, 64, 67, 75, 86, 17, 44, 83, 24, 87, 84, 23, 96, 79, 20, 13, 8, 11, 76, 88, 56, 38, 98, 29, 16, 99, 2, 66, 30, 48, 26, 5, 25, 78, 42, 47, 94, 15, 4, 55, 65, 97, and 71 were used. In set 2, genes 96, 98, 38, 32, 52, 25, 31, 14, 91,53, 8, 94, 49, 27, 69, 20, 44,4, 92, 56, 61, 97, 18, 65, 66, 54, 21, 3, 29, 79, 80, 70, 77, 50, 39, 99, 58, 23, 85, 51, 15, 72, 33, 19, 24, 68, 7, 41,81,64, 57, 73, 84, 46, 22, 74, 11, 45, 55, 82, 6, 47, 59, 42, 88, 9, 16, 34, 83, and 30 were used. In set 3, genes 27, 46, 30, 54, 47, 94, 26, 38, 73, 31,43, 8, 50, 48, 6, 56, 59, 25, 89, 52, 78, 68, 49, 29, 83, 92, 97, 98, 4, 3, 95, 87, 23, 1, 51, 44, 34, 35, 85, 61, 22, 84, 42, 13, 75, 93, 45, 88, 19, 80, 39, 24, 77, 2, 55, 62, 11, 90, 18, 81, 57, 20, 96, 28, 7, 70, 86, 5, 63, and 69 were used. In set 4, genes 65, 29, 88, 19, 42, 30, 15, 16, 74, 53, 25, 8, 95, 5, 69, 99, 59, 67, 84, 14, 80, 12, 37, 13, 71,39, 43, 100, 60, 79, 51, 11, 45, 82, 83, 61, 62, 90, 6, 20, 2, 18, 97, 1,48, 81, 35, 87, 56, 36, 93, 41, 54, 46, 10, 27, 47, 33, 55, 64, 26, 57, 85, 89, 9, 96, 72, 68, 23, and 32 were used. In set 5, genes 25, 41, 56, 91, 19, 22, 63, 39, 59, 83, 7, 74, 20, 86, 84, 2, 43, 73, 69, 58, 35, 26, 23, 42, 29, 10, 13, 77, 16, 72, 71, 81,40, 66, 80, 50, 12, 48, 64, 100, 24, 94, 97, 57, 98, 68, 78, 92, 53, 31,45, 38, 61, 75, 5, 1,44, 99, 3, 36, 88, 34, 21, 17, 15, 89, 37, 51, 85, and 79 were used. In set 6, genes 59, 78, 34, 83, 5, 11, 60, 97, 3, 9, 20, 90, 33, 8, 31, 10, 80, 7, 92, 15, 23, 72, 14, 86, 82, 18, 42, 88, 94, 48, 79, 73, 77, 52, 95, 16, 87, 28, 98, 71, 74, 21, 67, 6, 66, 35, 99, 29, 32, 75, 26, 39, 47, 45, 50, 41, 54, 1, 84, 85, 91, 100, 61, 12, 37, 4, 25, 55, 46, and 13 were used. In set 7, genes 63, 14, 66, 75, 12, 2, 90, 81, 27, 72, 70, 89, 59, 46, 6, 53, 22, 80, 30, 79, 82, 71, 92, 19, 73, 83, 38, 40, 1, 68, 20, 8, 50, 74, 94, 26, 35, 28, 43, 34, 77, 18, 96, 16, 95, 85, 15, 9, 11, 84, 39, 10, 54, 65, 57, 25, 60, 51, 55, 33, 17, 44, 29, 58, 93, 62, 21,4, 7, and 78 were used.

In set 8, genes 60, 76, 17, 29, 68, 24, 54, 87, 16, 66, 15, 8, 85, 92, 67, 100, 82, 74, 41, 33, 3, 35, 94, 78, 58, 75, 98, 63, 95, 12, 47, 81,91, 9, 7, 83, 77, 22, 89, 56, 49, 31, 96, 2, 70, 23, 46, 6, 39, 90, 59, 71, 44, 10, 36, 52, 42, 86, 5, 64, 55, 69, 84, 28, 93, 53, 38, 27, 13, and 26 were used. In set 9, genes 21,24, 41,29, 92, 30, 51,31, 83, 71,37, 23, 11, 53, 14, 93,45, 69, 52, 56, 70, 68, 3, 79, 26, 58, 66, 15, 50, 95, 16, 2, 4, 5, 28, 42, 34, 9, 82, 6, 63, 44, 87, 32, 59, 80, 55, 96, 54, 89, 22, 94, 36, 46, 40, 86, 98, 38, 67, 85, 35, 60, 25, 1, 78, 61, 17, 64, 7, and 91 were used. In set 10, genes 93, 44, 77, 3, 31, 64, 39, 89, 23, 51, 78, 85, 35, 81,22, 74, 97, 14, 27, 13, 16, 88, 28, 61, 57, 79, 99, 37, 30, 36, 24, 11, 45, 34, 54, 50, 41, 1, 7, 48, 56, 63, 58, 49, 17, 26, 15, 69, 2, 53, 43, 62, 55, 100, 95, 52, 83, 29, 19, 38, 59, 76, 20, 87, 66, 25, 72, 70, 4, and 73 were used.

[0135] For 75 genes, set 1, genes 73, 40, 56, 32, 59, 42, 70, 12, 100, 6, 28, 11,43, 55, 5, 64, 80, 99, 23, 57, 18, 82, 60, 61, 31, 81, 14,3, 91, 76, 86, 19,26,83, 38, 29, 8, 36, 69,85, 96, 27, 47, 10, 35,39, 94,24,62,34, 54, 65, 25, 90, 51, 67,41,46, 33, 1, 37,49, 9, 71, 13, 21,44, 2, 98, 52, 84, 20, 74, 93, and 88 were used. In set 2, genes 26, 21,43, 56, 15, 55, 9, 34, 58, 12, 85, 44, 20, 99, 74, 35, 39, 88, 53, 8, 92, 67, 6, 48, 69, 28, 23, 87, 71, 5, 72, 89, 38, 100, 25, 1, 13, 3, 14, 29, 96, 62, 64, 90, 78, 63, 68, 66, 11,41, 77, 42, 4, 60, 24, 98, 18, 17, 52, 46, 30, 32, 70, 33, 31, 83, 45, 36, 84, 95, 82, 80, 22, 50, and 73 were used. In set 3, genes 96, 11, 58, 14, 77, 32, 6, 28, 55, 12, 40, 72, 83, 7, 89, 67, 51, 63, 95, 15, 74, 99, 88, 81, 84, 38, 36, 13, 87, 5, 69, 62, 19, 86, 90, 76, 66, 33, 52, 4, 20, 78, 59, 27, 17, 2, 43, 75, 64, 79, 53, 26, 3, 42, 100, 48, 71, 85, 41,25, 61, 57, 49, 70, 37, 80, 24, 94, 30, 54, 9, 35, 21, 16, and 22 were used. In set 4, genes 48, 31, 73, 90, 10, 100, 32, 56, 83, 38, 93, 7, 53, 8, 79, 15, 63, 5, 92, 76, 58, 59, 35, 67, 2, 98, 23, 37, 24, 94, 25, 9, 46, 36, 82, 40, 89, 27, 34, 71,84, 97, 86, 6, 21, 54, 22, 72, 17, 44, 26, 57, 64, 11, 91,75, 80, 95, 62, 88, 51, 39, 99, 69, 43, 68, 42, 52, 16, 4, 30, 77, 81, 60, and 50 were used. In set 5, genes 86, 46, 90, 79, 40, 99, 53, 67, 97, 82, 7, 15,49, 71, 94, 48, 68, 80, 20, 51, 19, 96, 100, 38, 91,83, 50, 33, 76, 66, 93, 22, 74, 85,45, 31, 10, 62, 84, 25, 88, 77, 43, 78, 69, 24, 61, 57, 41, 56, 63, 32, 16, 59, 12, 4, 14, 28, 87, 44, 65, 55, 98, 35, 9, 64, 75, 47, 89, 18, 52, 36, 29, 54, and 81 were used. In set 6, genes 70, 47, 96, 46, 43, 2, 66, 39, 54, 40, 31, 84, 92, 30, 5, 75, 21, 9, 4, 24, 59, 90, 42, 44, 45, 97, 55, 69, 74, 79, 87, 86, 91, 56, 13, 98, 12, 64, 34, 99, 67, 83, 27, 68, 16, 10, 81, 61,80, 7, 94, 82, 49, 71, 53, 15, 76, 36, 11, 19, 41, 65, 8, 28, 14, 95, 62, 51, 63, 88, 3, 60, 18, 58, and 52 were used. In set 7, genes 90, 80, 39, 46, 51, 91,25, 16, 3, 36, 20, 30, 17, 99, 95, 44, 27, 89, 61,9, 65, 19, 86, 13, 84, 14, 5, 10, 82, 67, 85, 45, 59, 81,35, 41,4, 71, 32, 24, 22, 6, 53, 98, 54, 66, 42, 18, 97, 94, 87, 49, 79, 56, 72, 57, 76, 69, 28, 43, 23, 11,52, 92, 7, 93, 96, 75, 73, 8, 58, 83, 50, 29, and 68 were used. In set 8, genes 95, 93, 14, 43, 31,32, 100, 6, 92, 28, 68, 99, 35, 60, 90, 70, 22, 49, 54, 94, 56, 4, 97, 85, 2, 46, 11, 50, 63, 30, 38, 76, 39, 58, 64, 67, 83, 33, 88, 79, 87, 40, 57, 27, 55, 18, 3, 29, 82, 53, 98, 91, 61, 80, 26, 84, 20, 77, 86, 51, 1, 74, 23, 19, 10, 21, 47, 69, 24, 66, 81, 96, 15, 36, and 41 were used. In set 9, genes 33, 41,48, 68, 53, 45, 30, 79, 23, 70, 86, 13, 71, 92, 58, 1, 77, 26, 61,81, 69, 14, 73, 88, 44, 87, 74, 9, 4, 12, 20, 75, 60, 57, 55, 82, 22, 94, 46, 65, 16, 19, 52, 40, 59, 66, 64, 28, 96, 91, 93, 39, 72, 5, 98, 6, 3, 62, 24, 36, 49, 31,47, 90, 35, 89, 84, 99, 32, 11, 56, 17, 83, 51, and 97 were used. In set 10, genes 40, 10, 67, 9,43, 13, 52, 73, 50,41,54, 56, 98, 100, 83, 85, 28, 32,47, 66, 74,65, 79,81,94, 36, 90, 69, 31, 64, 88, 99,44, 18,33, 75, 95, 42, 58, 92, 15, 53, 97, 34, 63, 30, 24, 3, 45, 29, 82, 48, 17, 14, 26, 49, 93, 27, 87, 6, 57, 39, 68, 12, 70, 4, 25, 91,11, 89, 21, 23, 96, 84, and 46 were used.

[0136] For 80 genes, set 1, genes 75, 2, 91, 94, 19, 31,43, 50, 96, 49, 29, 14, 93, 58, 69, 82, 28, 6, 65, 26, 66, 40, 64, 34, 33, 53, 13, 4, 37, 80, 57, 59, 1, 87, 11, 16, 83, 21,35, 52, 25, 99, 45, 46, 36, 89, 88, 7, 39, 55, 90, 72, 17, 9, 85, 44, 22, 56, 8, 23, 18, 77, 12, 10, 48, 97, 61, 74, 92, 81, 95, 68, 47, 71,62, 24, 70, 20, 79, and 32 were used. In set 2, genes 1, 34, 89, 27, 22, 77, 28, 35, 11, 7, 39, 21, 46, 49, 74, 43, 13, 75, 14, 65, 73, 92, 19, 66, 29, 81, 88, 78, 40, 32, 12, 71, 9, 44, 23, 70, 45, 10, 98, 48, 68, 55, 82, 5, 56, 59, 15, 95, 33, 99, 87, 85, 18, 97, 100, 83, 53, 63, 6, 2, 37, 17, 67, 62, 50, 42, 25, 94, 31, 69, 90, 84, 64, 16, 57, 51, 54, 80, 86, and 38 were used. In set 3, genes 63, 28, 35, 67, 96, 9, 12, 31, 1, 59, 22,44, 11,82, 6, 64, 87, 47, 21, 94,42, 2, 72, 19, 20, 27, 89, 13, 77, 3, 16, 79, 38, 10, 80, 52, 50, 33, 25, 4, 30, 40, 32, 36, 8, 43, 26, 51, 18, 66, 61, 68, 56, 74, 53, 7, 73, 88, 49, 23, 46, 76, 92, 93, 83, 70, 24, 98, 97, 58, 65, 29, 55, 91, 95, 90, 5, 69, 86, and 78 were used. In set 4, genes 79, 72, 68, 31,42, 95, 78, 36, 10, 34, 59, 91,46, 40, 82, 1,44,4, 69, 3, 17, 43, 35, 63, 18, 13, 77, 81, 67, 26, 60, 86, 25, 61,89, 76, 55, 27, 22, 29, 20, 11, 7, 30, 54, 39, 62, 8, 74, 28, 71, 12, 38, 65, 66, 64, 21,9, 56, 16, 88, 99, 96, 32, 94, 51,90, 37, 87, 92, 97, 70, 41,57, 50, 45, 83, 24, 48, and 58 were used. In set 5, genes 100, 69, 33, 24, 83, 84, 97, 22, 40, 45, 17, 3, 43, 52, 50, 30, 8, 99, 9,46, 7, 14,35,61, 15, 16, 64, 6, 23,41,60,63, 96, 98, 38, 36,49, 13, 76,85,87, 71, 66, 56, 80, 20, 34,29, 57, 91,81,78, 27, 88, 37, 94, 51, 5, 1, 74, 44, 70, 58, 25, 19, 89, 39, 47, 65, 62, 68, 95, 18, 75, 79, 59, 2, 10, 73, and 53 were used. In set 6, genes 69, 100, 3, 35, 58, 56, 96, 43, 39, 50, 61, 36, 71, 95, 30, 18, 90, 63, 21, 31, 94, 46, 44, 23, 7, 10, 88, 49, 9, 53, 25, 54, 2, 97, 82, 75, 68, 48, 26, 91, 70, 65, 51, 19, 84, 29, 47, 12, 99, 85, 20, 16, 5, 22, 73, 93, 92, 89, 62, 81, 77, 41, 83, 1, 72, 27, 15, 79, 67, 37, 11,64, 87, 86, 80, 74, 55, 8, 13, and 60 were used. In set 7, genes 67, 73, 85, 95, 92, 60, 29, 28, 24, 90, 72, 71, 37, 76, 27, 78, 53, 34, 98, 70, 87, 33, 5, 41,42, 68, 62, 82, 100, 96, 69, 65, 6, 91, 21, 38, 3, 80, 25, 75, 31, 52, 79, 20, 84, 83, 19, 86, 57, 9, 77, 58, 64, 97, 14, 8, 50, 2, 51,94, 56, 46, 35, 93, 7, 39, 1,88, 59, 17, 48, 74, 32, 81, 99, 16, 11, 49, 13, and 30 were used. In set 8, genes 80, 52, 14, 42, 21, 76, 32, 69, 30, 60, 86, 61, 48, 24, 67, 92, 16, 75, 93, 2, 6, 99, 20, 73, 9, 97, 98, 56, 47, 12, 35, 26, 36, 41, 96, 55, 11,84, 7, 87, 4, 70, 79, 88, 44, 17, 50, 27, 89, 28, 29, 43, 77, 39, 8, 15, 91,65, 22, 71,53, 37, 34, 95, 83, 45, 68, 1, 18, 13, 31, 85, 3, 90, 51,49, 19, 66, 63, and 54 were used. In set 9, genes 91,22, 68, 85, 53, 89, 10, 77, 97, 4, 7, 33, 46, 51, 14, 76, 82, 62, 17, 3, 65, 70, 84, 75, 31, 50, 73, 63, 19, 52, 42, 26, 23, 47, 96, 2, 64, 56, 9, 54, 38, 93, 13, 90, 86, 8, 59, 57, 79, 28, 21, 88, 5, 66, 1, 94, 55, 35, 15, 87, 74, 32, 27, 92, 72, 18, 69, 80, 37, 67, 71, 34, 95, 99, 40, 83, 30, 81,48, and 39 were used. In set 10, genes 92, 76, 86, 5, 20, 1,48, 42, 62, 29, 12, 7, 37, 46, 47, 82, 32, 66, 97, 77, 56, 91, 30, 80, 36, 72, 17, 31, 2, 81,23, 28, 51, 55, 98, 40, 95, 13, 10, 58, 33, 21, 14, 74, 85, 88, 22, 75, 94, 27, 43, 3, 100, 61, 67, 4, 25, 6, 44, 60, 24, 93, 63, 89, 70, 41, 15, 11, 53, 87, 16, 65, 52, 68, 57, 99, 50,45, 71, and 38 were used.

[0137] For 85 genes, set 1, genes 38, 35, 85, 59, 17, 7, 31,58, 96, 97, 16, 70, 82, 42, 21, 54, 88, 34, 63, 4, 27, 29, 3, 19, 69, 36, 9, 99, 74, 86, 76, 24, 15, 81, 73, 93, 40, 52, 26, 57, 37, 87, 55, 90, 41, 79, 45, 77, 91, 71, 61, 11, 94, 83, 25, 48, 1, 5, 8, 22, 33, 46, 60, 56, 20, 44, 89, 18, 10, 23, 78, 65, 50, 72, 75, 47, 98, 28, 66, 68, 32, 12, 51, 13, and 100 were used. In set 2, genes 32, 90, 94, 21, 77, 63, 17, 27, 62,41,35, 81, 100, 14, 45, 69, 3, 75, 34, 76, 65, 15, 95, 86, 39, 92, 89, 24, 57,4, 54, 50, . 58, 88, 5, 56, 22, 59, 6, 52, 28, 1, 9, 40, 98, 99, 91, 19, 8, 23, 96, 2, 73, 67, 7, 25, 53, 12, 44, 18, 13, 87, 60, 49, 93, 55, 20, 72, 42, 66, 30, 80, 33, 26, 64, 46, 84, 31, 70, 61, 71, 83, 38, 36, and 29 were used. In set 3, genes 88, 20, 1, 58, 53, 32, 65, 34, 50, 75, 71, 36, 59, 39, 30, 61, 8, 62, 14, 3, 94, 66, 35, 37, 17, 47, 77, 60, 4, 80, 74, 28, 97, 87, 93, 33, 64, 48, 29, 18, 49, 21, 56, 69, 22, 25, 43, 54, 91, 7, 81,79, 12, 85, 96, 40, 63, 52, 82, 86, 41, 24, 44, 84, 70, 6, 15, 38, 57, 16, 55, 90, 76, 42, 51, 23, 11,67, 45, 98, 19, 10, 27, 2, and 31 were used. In set 4, genes 64, 86, 54, 83,47, 21,67, 57, 73, 23, 71, 76, 56, 9, 44, 75, 82, 11,8, 99, 72, 13, 79, 28, 92, 5, 27, 90, 24, 91,33, 68, 51, 60, 94, 58, 78, 48, 18, 42, 53, 98, 70, 32, 41,49, 45, 6, 30, 63, 95, 80, 36, 87, 97, 65, 77, 3, 26, 35, 59, 40, 84, 37, 61,81, 39, 46, 22, 1, 2, 50, 25, 69, 4, 43, 15, 29, 20, 17, 88, 10, 38, 100, and 19 were used. In set 5, genes 11, 92, 15, 42, 33, 19, 6, 57, 23, 87, 31, 5, 30, 21, 54, 51, 14, 68, 97, 34, 59, 24, 20, 50, 29, 65, 13, 80, 16, 73, 8, 25, 47, 55, 27, 45, 100, 96, 85, 38, 37, 81,44, 4, 9, 70, 98, 77, 48, 35, 28, 79, 41, 71, 86, 61, 2, 49, 60, 67, 66, 69, 72, 3, 83, 26, 1, 89, 17, 39, 52, 10, 32, 75, 82, 99, 40, 95, 90, 53, 22, 91, 62, 78, and 56 were used. In set 6, genes 87, 32, 4, 63, 15, 81, 92, 10, 74, 44, 7, 23, 89, 93, 28, 59, 50, 72, 30, 60, 54, 71,39, 12, 21, 85, 40, 37, 68, 64, 97, 66, 52, 67, 98, 91, 1, 83, 61, 6, 24, 38, 86, 77, 26, 88, 43, 100, 48, 20, 14, 31, 82, 9, 13, 62, 55, 45, 57, 11, 27, 90, 25, 80, 17, 5, 94, 42, 53, 49, 29, 99, 78, 2, 84, 73, 58, 75, 18, 19, 65, 3, 47, 41, and 36 were used. In set 7, genes 56, 38, 23, 74, 34, 99, 93,4, 13, 18, 61,49, 20, 5, 76, 88, 91,31, 78, 32, 1, 89, 12, 16, 51,54, 81,70, 86, 97, 66, 19, 59, 39, 8, 80, 73, 35, 71, 77, 24, 53, 68, 33, 62, 69, 43, 41, 15, 94, 44, 52, 29, 100, 55, 36, 27, 25, 67, 21, 96, 30, 42, 92, 11, 3, 45, 63, 72, 57, 47, 46, 75, 90, 2, 48, 14, 6, 9, 87, 22, 98, 95, 84, and 65 were used. In set 8, genes 79, 64, 71, 18,37,40, 54,34,26,65, 39, 67, 14, 62, 95, 11,49, 92, 59,48, 6, 12, 57, 9, 20, 81, 16, 50, 38, 33, 100, 47, 63, 3, 84, 87, 35, 98, 56, 93, 66, 23, 2, 29, 90, 78, 85, 60, 19, 72, 97, 36, 13, 94, 25, 45, 41, 27, 69, 52, 8, 68, 46, 30, 1, 96, 7, 83, 80, 4, 99, 15, 76, 10, 58, 89, 88, 51, 55, 82, 53, 28, 44, 73, and 77 were used. In set 9, genes 35, 85, 81,4, 20, 88, 66, 74, 13, 36, 6, 24, 95, 97, 2, 21, 90, 57, 89, 42, 73, 79, 64, 59, 46, 68, 92, 67, 82, 28, 56, 14, 65, 99, 39, 38, 8, 62, 61,78, 11, 48, 93, 91, 29, 33, 76, 16, 69, 47, 84, 94, 7, 54, 30, 32, 23, 70, 52, 43, 51, 41, 60, 100, 27, 63, 75, 77, 80, 5, 3, 44, 10, 87, 40, 71, 37, 72, 1, 53, 22, 83, 49, 17, and 34 were used. In set 10, genes 23, 39, 86, 48, 65, 73, 24, 27, 61,37, 99, 64, 58, 74, 3, 22, 57, 60, 13, 93, 44, 100, 66, 69, 38, 83, 6, 81, 59, 36, 68, 95, 71, 70, 84, 62, 96, 26, 30, 32, 20, 54, 80, 19, 97, 16, 4, 77, 12, 5, 35, 29, 18, 52, 53, 87, 98, 90, 10, 75, 72, 55, 50, 88, 28, 34, 41,94, 11, 76, 7, 45, 31,46, 49, 9, 82, 17, 79, 1, 25, 40, 67, 47, and 85 were used.

[0138] For 90 genes, set 1, genes 79, 5, 27, 100, 96, 11,32, 63, 42, 68, 13, 65, 88, 75, 17, 64, 82, 72, 37, 45, 98, 2, 90, 94, 1, 87, 73, 86, 69, 92, 3, 25, 29, 84, 60, 50, 39, 4, 95, 47, 12, 10, 33, 22, 77, 71, 57, 97, 38, 89, 91, 53, 51, 9, 67, 44, 7, 78, 34, 85, 15, 41,54, 49, 62, 76, 83,46, 59, 23, 24, 8, 14, 26, 30, 52, 18, 6, 66, 31, 20, 93, 36, 16, 61,28, 74,43, 56, and 48 were used. In set 2, genes 95, 28, 46, 62, 91, 99, 53, 65, 66, 60, 22, 29, 50, 2, 93, 33, 54, 57, 92, 24, 9, 4, 69, 5, 8, 58, 88, 43, 6, 100, 51, 18, 16, 45, 81,44, 68, 14, 59, 82, 63, 73, 30, 86, 98, 13, 84, 94, 1, 55, 38, 83, 3, 37, 11, 89, 77, 85, 26, 97, 12, 21, 40, 96, 56, 41, 10, 42, 64, 17, 76, 27, 49, 20, 87, 34, 75, 15, 74, 35, 19, 31, 39, 48, 23, 67, 78, 32, 7, and 80 were used. In set 3, genes 88, 89, 6, 94, 17, 60, 8, 76, 45, 90, 47, 80, 15, 85, 51, 5, 46, 36, 65, 4, 25, 67, 78, 77, 97, 23, 11,40, 61,53, 39, 12, 38, 21, 59, 55, 32, 34, 71, 69, 20, 50, 93, 3, 30, 29, 75, 73, 49, 98, 58, 43, 18, 95, 42, 82, 66,16, 33, 37, 92, 52, 56, 41, 87, 99, 74, 24, 86, 48, 81, 57, 83, 26, 79, 68, 13, 63, 72, 9, 70, 14, 54, 100, 64, 19, 96, 7, 31, and 2 were used. In set 4, genes 19, 33, 41, 40, 70, 51, 14, 48, 42, 12, 90, 4, 32, 60, 89, 64, 45, 86, 73, 16, 50, 5, 9, 72, 81, 3, 27, 87, 76, 58, 29, 31, 13, 21, 55, 18, 6, 62, 56, 96, 47, 63, 37, 98, 28, 91, 36, 82, 39, 100, 68, 25, 88, 11, 93, 35, 66, 24, 43, 59, 8, 65, 74, 30, 10, 22, 17, 99, 49, 44, 26, 54, 2, 80, 94, 57, 71,38, 67, 79, 75, 77, 23, 85, 61,52, 83, 7, 78, and 53 were used. In set 5, genes 49, 55, 13, 97, 59, 83, 61, 34, 80, 19, 12, 65, 86, 72, 89, 25, 39, 77, 82, 47, 22, 48, 20, 11,23, 84, 31, 4, 54, 91, 8, 87, 33, 14, 32, 45, 68, 27, 51, 28, 96, 1, 100, 92, 37, 29, 64, 15, 7, 98, 60, 53, 17, 69, 24, 75, 81,74, 5, 18, 26, 78, 62, 94, 88, 46, 73, 44, 63, 52, 9, 93, 76, 6, 95, 99, 42, 50, 66, 38, 90, 70, 35, 57, 85, 58, 16, 43, 30, and 10 were used. In set 6, genes 81, 52, 60, 16, 18, 40, 67, 47, 58, 51, 26, 5, 53, 34, 24, 68, 14, 43, 49, 69, 99, 73, 29, 96, 37, 62, 66, 38, 88, 48, 11, 50, 79, 74, 15, 39, 83, 57, 94, 95, 100, 12, 84, 10, 33, 3, 93, 91, 17, 46, 59, 86, 7, 9, 71, 19, 22, 80, 27, 97, 4, 75, 89, 21, 78, 85, 63, 61, 77, 31, 32, 56, 6, 72, 92, 55, 76, 90, 36, 35, 98, 1, 82, 25, 23, 44, 65, 64, 28, and 42 were used. In set 7, genes 51, 1, 54, 94, 93, 56, 22, 29, 53, 67, 88, 82, 16, 44, 65, 21, 14, 35, 48, 91, 12, 97, 31.74, 6, 99, 86, 26, 28, 19, 72, 58, 24, 34, 5, 38, 81, 11,49, 39, 3, 89, 75, 64, 96, 52, 59, 69,42, 78, 33, 100, 2, 25, 66, 77, 90, 40, 71, 9, 4, 57, 13, 36, 10, 50, 17, 87, 15, 47, 60, 46, 63, 68, 70, 23, 80, 37, 30, 92, 7, 32, 27, 43, 98, 84, 8, 61, 73, and 41 were used. In set 8, genes 53, 63, 17, 43, 6, 44, 95, 58, 78, 13, 3, 15, 28, 41, 12, 93, 2, 92, 23, 42, 62, 57, 33, 8, 65, 49, 80, 81, 50, 71.74, 39, 4, 70, 77, 51,84, 21, 30, 36, 46, 75, 47, 94, 16, 67, 55, 1, 26, 52, 60, 19, 59, 90, 96, 14, 87, 37, 40, 66, 88, 73, 29, 10, 5, 56, 100, 45, 31,34, 22, 64, 91, 54, 48, 25, 98, 61, 18, 72, 69, 27, 68, 99, 83, 35, 24, 82, 85, and 38 were used. In set 9, genes 62, 91,49, 28, 69, 38, 19, 35, 89, 3, 24, 79, 32, 12,47,40, 39, 50, 86, 6, 44, 65, 33, 70, 16, 41,21, 53, 72, 74, 87, 14, 51, 7, 60, 67, 100, 42, 93, 36, 2, 57, 76, 20, 25, 27, 95, 18, 73, 97, 54, 99, 63, 66, 96, 22, 77, 56, 90, 81, 61, 17, 48, 23, 15, 4, 30, 45, 59, 8, 71,52, 85, 92,46, 98, 64, 94, 75, 83, 13, 26, 43, 84, 5, 1,29, 68, 82, and 31 were used. In set 10, genes 45, 10, 63, 9, 18, 7, 70, 50, 22, 52, 91, 88, 5, 38, 17, 80, 54, 92, 20, 19, 24, 8, 13, 40, 15, 21, 87, 72, 12, 14, 2, 53, 46, 93, 4, 44, 99, 76, 47, 32, 60, 27, 23, 81, 78, 68, 36, 71, 64, 30, 95, 82, 90, 26, 74, 86, 100, 89, 62, 37, 66, 35, 83, 94, 31, 43, 65, 84, 11, 67, 25, 33, 61,79, 97, 16, 75, 73, 98, 57, 28, 59, 1,96, 51,41, 69, 3, 56, and 55 were used.

[0139] For 95 genes, set 1, genes 35, 64, 32, 25, 20, 69, 88, 42, 97, 6, 23, 86, 98, 93, 16,44, 53, 51, 91, 21, 70, 73, 31,81,74, 14, 29, 66, 4, 87, 11, 94, 52, 95, 56, 63, 18, 8, 78, 100, 62, 99, 39, 89, 17, 50, 71, 10, 90, 65, 84, 83, 60, 48, 22, 5, 92, 13, 15, 24, 27, 37, 57, 33, 38, 82, 3, 9, 30, 1, 34, 7, 40, 68, 67, 58, 28, 47, 46, 19, 12, 43, 41,61, 76, 96, 72, 36, 75, 54, 45, 80, 49, 79, an d55 were used. In set 2, genes 58, 44, 39, 62, 1, 19, 61, 33, 84, 36, 91, 21, 53, 30, 63, 35, 92, 45, 11, 87, 10, 82, 96, 64, 8, 32, 42, 78, 69, 59, 24, 72, 48, 66, 15, 27, 49, 75, 40, 47, 57, 52, 31, 95, 97, 94, 26, 5, 93, 34, 60, 81, 88, 29, 23, 67, 76, 6, 98, 37, 74, 43, 100, 20, 18, 12, 13, 51,41,54, 14, 2, 68, 99, 3, 38, 70, 77, 50, 4, 17, 22, 9, 83, 71, 85, 25, 79, 46, 86, 7, 73, 16, 65, and 28 were used. In set 3, genes 15, 4, 25, 94, 92, 77, 78, 70, 17, 52, 36, 23, 44, 98, 39, 99, 59, 50, 75, 16, 82, 48, 18, 90, 10, 72, 8, 34, 9, 19, 1, 57, 93, 46, 54, 69, 32, 21, 81, 91, 28, 38, 68, 3, 41, 47, 87, 63, 24, 13, 84, 5, 65, 67, 74, 62, 85, 12, 53, 30, 73, 51,2, 80, 29, 26, 83, 43, 55, 86, 88, 89, 35, 66, 31, 96, 100, 58, 60, 14, 6, 61,49, 22, 20, 27, 7, 64, 37, 45, 97, 95, 40, 71, and 11 were used. In set 4, genes 21,78, 42, 23, 84, 10, 64, 36, 48, 26, 79, 71, 72, 39, 49, 56, 44, 20, 47, 82, 63, 1, 91,2, 8,40, 96, 18, 68, 9, 57, 28, 100, 89, 60, 75, 70, 73, 25, 15, 46, 85, 86, 97, 32, 94, 65, 90, 74, 98, 16, 45, 3, 6, 31, 77, 41, 11, 12, 35, 95, 93, 53, 50, 30, 61, 81, 92, 80, 54, 13, 38, 58, 14, 52, 22, 76, 83, 5, 17, 37, 69, 66, 87, 19, 88, 51, 34, 59, 99, 24, 33, 27, 4, and 62 were used. In set 5, genes 29, 34, 28, 58, 89, 1,73, 30, 92, 76, 68, 33, 38, 8, 49, 3, 42, 9, 40, 36, 43, 81,97, 59, 7, 79, 54, 15, 11,61, 18, 82, 100,41,52, 23, 31, 13, 57, 66, 65, 27, 72,44, 16, 69, 39, 26, 2, 55, 71,80, 86, 77, 12, 25, 14, 50, 88, 22, 93, 51,75, 64, 47, 62, 96, 10, 35, 5, 67, 60, 32, 84, 94, 48, 56, 90, 95, 83, 21, 6, 37, 91, 46, 70, 24, 87, 85, 17, 98, 99, 45, 19, and 63 were used. In set 6, genes 36, 34,46, 2, 5, 77, 91, 59, 61,29, 9, 85, 52, 16, 17, 60, 51, 95, 69, 58, 57, 23, 82, 33, 18, 45, 43, 49, 90, 1, 94, 93, 47, 37, 35, 63, 27, 96, 32, 15, 25, 86, 55, 24, 26, 71,48, 7, 28, 79, 11,44, 76, 3, 68, 88, 62, 73, 54, 39, 22, 13, 75, 19, 66, 98, 70, 10, 83, 100, 42, 31, 38, 4, 92, 78, 99, 97, 56, 21, 20, 6, 72, 40, 65, 67, 53, 30, 8, 14, 84, 50, 12, 80, and 81 were used. In set 7, genes 26, 7, 14, 64, 91,50, 8, 48, 23, 29, 34, 28, 9, 20, 74, 97, 27, 63, 25, 66, 60, 43, 92, 61, 58, 46, 68, 49, 21,98, 2, 41,52, 1, 51, 77, 53, 69, 36, 93, 62, 55, 17, 38, 31, 40, 76, 54, 71, 5, 99, 83, 82, 78, 42, 15, 24, 70, 84, 100, 73, 10, 59, 33, 96, 4, 56, 3, 94, 75, 90, 13, 32, 65, 89, 79, 19, 30, 11,87, 37, 95, 12, 6, 88, 80, 18,47, 81,72,44, 16, 86, 85, and 67 were used. In set 8, genes 24, 84, 92, 71, 56, 68, 93, 67, 59, 75, 85, 35, 72, 86, 39,46, 65, 51, 23, 100, 8, 37, 70, 69, 57, 27, 17, 87,44, 1, 2, 50, 9, 91, 63, 29, 95, 3, 5, 40, 96,47, 54, 64, 66, 18, 28, 13, 14, 36, 80, 21, 12, 61,48, 26, 88, 83, 7, 43,42, 97, 99, 41, 10, 16, 94, 53, 45, 98, 5, 73, 89, 55, 74, 81, 20, 90, 79, 34, 38, 82, 76, 4, 60, 33, 31, 78, 58, 62, 22, 6, 52, 49, and 19 were used. In set 9, genes 99, 77, 10, 92, 24, 43, 41, 15, 46, 78, 38, 19, 2, 5, 3, 81,82, 22, 56, 63, 47, 90, 33, 34, 75, 100, 62, 6S, 13, 30, 95, 98, 94, 25, 67, 11, 6, 66, 14, 48, 93, 4, 21, 89, 35, 68, 97, 45, 27, 59, 76, 85, 42, 49, 23, 40, 37, 74, 26, 52, 8, 91, 53, 57, 58, 86, 31, 20, 9,16, 84, 69, 96,44, 32, 54, 60, 7, 51,83, 72, 28, 29, 61,80, 55, 64, 17, 18, 70, 50,1, 12, 73, and 39 were used. In set 10, genes 76, 1, 12, 25, 77, 24, 100, 17, 66, 65, 26, 29, 60, 91,63, 52, 6, 30, 8, 72, 82, 68, 15, 16, 54, 43, 59, 34, 89, 20, 44,87, 70, 56, 3,28, 74,86, 7, 2, 33, 35,46, 67, 58, 22,49, 21,75, 14, 27,64, 90,42, 73, 36, 97, 40, 11,37, 51, 19, 83,45, 47, 50, 55, 23, 80, 61,95, 71,78, 32, 81, 93, 98, 62, 92, 99, 9, 4, 53, 84, 18, 13, 41, 57, 88, 5, 79, 38, 39, 31, and 94 were used.

[0140] Classification of subsets of the 39 tumor types was performed with use of random selections of tumor types from the group of 39. The expression levels of gene sequence sets as described herein were.used to classify random combinations of tumor types. Different random sets of tumor types were used with each of the sets of 100, 74, and 90 gene sequences as described in these examples. Representative, and non-limiting, examples of random sets of from 2 to 20 tumor types used are as follows, where the set of 39 tumor types were indexed from 1 to 39.

[0141] For 2 tumor types, set 1 used types 26 and 16. Set 2 used types 8 and 5. Set 3 used types 39 and 8. Set 4 used types 27 and 23. Set 5 used types 8 and 19. Set 6 used 12 and 21. Set 7 used types 30 and 15. Set 8 used types 30 and 5. Set 9 used types 18 and 22. Set 10 used types 27 and 26.

[0142] For 4 tumor types, set 1 used types 20, 35, 15 and 7. Set 2 used types 36, 1,28 and 19. Set 3 used types 13, 4, 12 and 21. Set 4 used types 12, 33, 14 and 28. Set 5 used types 6, 28, 5 and 37. Set 6 used types 5, 25, 36 and 15. Set 7 used types 12, 26, 21 and 19. Set 8 used types 19, 3, 20 and 17. Set 9 used types 18, 10, 8 and 9. Set 10 used types 28, 20, 2 and 22.

[0143] For 6 tumor types, set 1 used types 27, 3, 10, 39, 11 and 20. Set 2 used types 33, 10, 20, 32, 13 and 19. Set 3 used types 31,27, 18, 39, 8 and 16. Set 4 used types 25, 28, 10, 12, 7 and 39. Set 5 used types 14, 13, 28, 24, 30 and 36. Set 6 used types 9, 24, 8, 17, 36 and 26. Set 7 used types 20, 1,34, 26, 6 and 19. Set 8 used types 12, 13, 3, 17, 34 and 22. Set 9 used types 7, 1, 17, 13, 20 and 34. Set 10 used types 5, 11,25, 29, 28 and 35.

[0144] For 8 tumor types, set 1 used types 34, 33, 28, 3, 23, 25, 9 and 29. Set 2 used types 27, 8, 38, 28, 20, 14, 12 and 9. Set 3 used types 29, 21, 19, 1, 13, 26, 11 and 31. Set 4 used types 25, 17, 7, 20, 34, 8, 28 and 10. Set 5 used types 36, 28, 35, 26, 2, 8, 29 and 7. Set 6 used types 10, 23, 2, 27, 33, 21, 25 and 35. Set 7 used types 10, 18, 38, 2, 6, 7, 19 and 32. Set 8 used types 11, 37, 6, 28, 3, 9, 2 and 16. Set 9 used types 22, 2,, 10, 8, 17, 19 and 33. Set 10 used types 35, 39, 8, 10, 37, 4, 36 and 6.

[0145] For 10 tumor types, set 1 used types 25, 10, 26, 2, 32, 31, 39, 23, 22 and 18. Set 2 used types 12, 35, 6, 16, 20, 3, 39, 36, 11 and 2. Set 3 used types 34, 1, 15, 29, 5, 39, 2, 12, 25 and 18. Set4 used types 10, 8, 14, 18, 31, 19, 23, 20, 32 and 33. Set 5 used types 10, 18, 37, 15, 4, 35, 33, 24, 39 and 20. Set 6 used types 22, 16, 4, 3, 18, 21, 1, 25, 37 and 13. Set 7 used types 14, 6, 28, 18, 11, 13, 2, 32, 33 and 19. Set 8 used types 39, 2, 38, 4, 34, 8, 25, 6, 32 and 35. Set 9 used types 3, 10, 11, 16, 6, 15, 18, 14, 12 and 26. Set 10 used types 24, 25, 21,9, 36, 29, 20, 39, 10 and 37.

[0146] For 12 tumor types, set 1 used types 26, 20, 4, 12, 2, 31, 38, 18, 16, 39, 3 and 33. Set 2 used types 25, 16, 4, 9, 29, 27, 14, 24, 21, 7, 23 and 2. Set 3 used types 31, 18, 23, 13, 25, 1, 29, 21, 35, 10, 32 and 39. Set 4 used types 8, 34, 23, 9, 35, 14, 25, 21, 2, 33, 18 and 28. Set 5 used types 6, 11,21,8, 5, 7, 19, 32,3, 13, 36 and 9. Set 6 used types 12, 33, 14, 26, 27, 15, , 2, 21,36, 35, 9 and 39. Set 7 used types 26, 29, 32, 17, 31, 19, 6, 5, 20, 34, 2 and 24. Set 8 used types 17, 12,8, 22, 28, 9, 27, 29, 14, 35, 4 and 32. Set 9 used types 29, 9, 36, 23, 33, 18, 21,35, 3, 6, 2 and 1. Set 10 used types 1,3, 35, 29, 22, 27, 8, 23, 2, 36, 14 and 19.

[0147] For 14 tumor types, set 1 used types 9, 26, 38, 25, 31, 3, 15, 14, 17, 33, 12, 35, 39 and 16. Set 2 used types 1,26, 16, 25, 20, 12, 14, 37, 38, 24,23, 33, 27 and 35. Set 3 used types 11, 21, 35, 38, 32, 34,27, 39, 16, 15,4, 5, 13 and 18. Set 4 used types 27, 5, 13, 28, 18, 17, 15, 20, 29, 37, 21, 36, 25 and 14. Set 5 used types 5, 12, 17, 9, 25, 21, 33, 37, 8, 15, 24, 3, 34 and 28. Set 6 used types 11, 19, 34, 26, 9, 6, 32, 14, 27, 29, 30, 16, 24 and 17. Set 7 used types 31,26, 11, 18, 19, 20, 9, 8, 5, 36, 12,6, 27 and 38. Set 8 used types 20, 17, 11,5, 15,9,2, 39,34,24, 27, 26, 35 and 10. Set 9 used types 1, 14, 39,30, 17,6, 10, 35, 31,33, 15, 29, 32 and 7. Set 10 used types 1,19, 24, 28, 34, 12, 13, 18, 32, 11, 14, 21,22 and 25.

[0148] For 16 tumor types, set 1 used types 27, 15, 8, 12, 6, 20, 26, 19, 25, 2, 37, 38, 7, 39, 4 and 33. Set 2 used types 17, 18, 28, 5, 6, 31, 25, 13, 8, 20, 37, 36, 35, 9, 23 and 27. Set 3 used types 23, 37, 34, 14, 16, 27, 32, 33, 21, 38, 4, 30, 24, 22, 17 and 25. Set 4 used types 7, 37, 38, 21,34, 31,32,25, 10, 36, 19, 11,6, 26, 18 and 35. Set 5 used types 9, 32, 12,24,20, 13, 38,21, 39,23, 36, 18, 37, 22, 5 and 3. Set 6 used types 14, 21, 5, 17, 6, 20, 18, 35, 22, 10, 3, 23, 13, 2, 34 and 26. Set 7 used types 1, 8, 19, 6, 9,39, 28, 18, 13, 31, 14, 16, 37, 12, 3 and 25. Set 8 used types 32, 36, 28, 38, 9, 33,2, 5, 4, 11, 19, 18, 13, 8, 12 and 3. Set 9 used types 9, 14, 10, 5, 28, 32, 23, 6, 39, 3, 17, 8, 19, 1,31 and 12. Set 10 used types4, 34, 11, 6, 38, 19, 7, 20, 23, 3, 25, 37, 26,1,15 and 12.

[0149] For 18 tumor types, set 1 used types 15, 24, 39, 35, 7, 30, 16, 13, 20, 3, 26, 4, 12, 10, 34, 25, 21 and 28. Set 2 used types 21,23, 29, 11, 10, 19, 13, 28,4, 20, 17, 24, 30, 12, 39, 34, 31 and 9. Set 3 used types 7, 17, 27, 6, 30, 8, 22, 2, 32, 26, 21, 14,4, 38, 1,35, 16 and 28. Set 4 used types 17, 13, 20, 33, 10, 3, 16, 22, 1,38, 2, 9, 28, 5, 6, 19, 12 and 11. Set 5 used types 4, 35, 21, 25, 18, 17, 8, 14, 31, 30, 9, I, 2, 23, 36, 29, 32 and 37. Set 6 used types 17, 34, 2, 18, 19, 15, 16, 13, 4, 24, 5, 35, 6, 22, 28, 37, 38 and 1. Set 7 used types 34, 26, 12, 25, 27, 3, 17, 7, 2, 32, 9, 36, 21, 19, 22, 8, 20 and 29. Set 8 used types 12, 34, 38, 25, 17, 22, 14, 39, 10, 7, 31, 2, 3, 11, 29, 30, 16 and 24. Set 9 used types 13, 26, 27, 14, 5, 10, 8, 7, 16, 30, 37, 4, 6, 35, 28, 1, 36 and 20. Set 10 used types 15, 2, 17, 23, 26, 28, 36, 38, 12, 6, 19, 37, 20, 14, 9, 39, 11 and 21.

[0150] For 20 tumor types, set 1 used types 25, 13, 21, 15, 37, 20, 12, 28, 9, 10, 26, 22, 14, 24, 16, 7, 39, 34, 33 and 4. Set 2 used types 20, 17, 10, 27, 19, 28, 5, 1,23, 21,38, 7, 13, 22, 32, 31, 9,4, 3 and 24. Set 3 used types 17, 13, 7, 20, 11, 38, 34, 3, 15, 12, 5, 39, 9, 10, 4, 35, 27, 6, 21 and 33. Set 4 used types 6, 13, 17, 26, 1, 7, 33, 5, 10, 32, 3, 23, 35,4, 14, 28, 12, 38, 8 and 27. Set 5 used types 10, 23, 9, 38, 5, 29, 12, 27, 25, 6, 7, 26, 37, 31, 24, 36, 19, 15, 16 and 11. Set 6 used types 30, 24, 21, 11, 23, 25, 8, 9, 7, 31, 27, 5, 14, 29, 1, 19, 16, 12, 22 and 17. Set 7 used types 26, 13, 23, 19, 22, 11,25, 21, 33, 20, 6, 17, 2, 10, 31,34, 27, 37, 7 and 9. Set 8 used types 30, 1, 38, 7, 31, 37, 11,25, 6, 19, 28, 33, 17, 29, 10, 27, 16, 3, 14 and 15. Set 9 used types 15, 19, 26, 24, 5, 33, 11, 2, 13, 18, 31, 22, 32, 20, 23, 6, 10, 25, 36 and 3. Set 10 used types 24, 25, 21, 29, 14, 18, 31, 2, 20, 39, 23, 9, 38, 12, 6, 32, 22, 26, 33 and 7.

Example 4. Specified gene sets [0151] Afirst set of 74 genes and a second set of 90 genes, where the two sets have 38 members in common, were used in the practice of the invention. The performance of the two sets versus varying numbers of tumor types is shown in Figure 3.

[0152] Random subsets of 50 to all members of the set of 74 expressed gene sequences were evaluated in a manner analogous to that described in Example 3. Again, the expression levels of random combinations of 50, 55, 60, 65, 70, and all 74 (each combination sampled 10 times) of the 74 expressed sequences were used with data from tumor types and then used to predict test random sets of tumor samples (each sampled 10 times) ranging from 2 to all 39 types. The resulting data are shown in Figures 4 and 5.

[0153] The members of the 74 gene sequences were indexed from 1 to 74, and representative random sets used in the invention are as follows: [0154] For 50-genes, set 1, genes 69, 64, 74, 29,4, 57, 30, 72, 36, 59,42,47, 11, 33,60, 35, 39, 10, 50,49,41, 12, 34, 51,32, 66, 71, 37, 13, 14, 8, 25, 53, 21, 68, 7, 67, 55, 27, 22, 1,44,46, 28, 48, 19, 73, 23, 16, and 3 were used. In set 2, genes 60, 61, 23, 17, 10, 31, 16, 8, 72, 73, 18, 49, 71,46, 29,21,66, 39,22, 27, 43, 30, 51, 3, 38, 19, 37, 35, 70, 54, 40, 2, 55, 28,45, 33,25, 14, 48, 20, 36, 47, 62, 9, 69, 68, 53, 58, 15, and 7 were used. In set 3, genes 53, 68, 31, 2, 62, 17, 49, 71, 6, 56, 3, 66, 23, 21 ,33, 30, 45, 73, 74, 11,58, 27, 64, 18, 72, 42, 7, 28, 34, 43, 38, 65, 12, 47, 16, 40, 41, 36, 54, 61, 19, 63, 25, 46, 59, 9, 39, 55, 22, and 48 were used. In set 4, genes 23, 70, 48, 1,11,25, 60, 26, 5, 58,46, 39, 28, 71,35, 34, 2, 59, 69, 55,49,40,15, 14, 68, 57, 10, 31, 67, 74, 62, 44, 16,12, 64, 63, 61,13, 52,45,19, 50, 36, 33, 9, 24, 32, 29, 56, and 72 were used. In set 5, genes 30, 26, 10, 34, 67, 73, 15, 59, 3, 64, 14, 70, 23, 47, 72, 71,44, 49, 31, 48, 5, 61, 53, 20, 33, 58, 37, 50, 43, 18, 21, 38, 29, 16, 12, 63, 39,4,45, 60,69, 25, 24,65, 55, 13,36, 11, 17, and 22 were used. In set 6, genes 43, 34,61, 19, 35, 56,24, 3, 23, 15, 13,69, 1, 67, 42, 41,64, 25, 63, 28, 8, 53, 38, 71, 6, 36, 68, 14, 18, 65, 51, 33, 4, 60, 5, 22, 40, 30, 50, 37, 29, 17, 27, 11, 9, 66, 62, 57, 59, and 10 were used. In set 7, genes 51, 55, 46, 31,21, 72, 8, 67, 56, 1,64, 6, 63, 32, 20, 16, 25, 61, 2, 45, 35, 22, 66, 38, 36, 3, 34,27, 74,47, 54,30, 14, 13, 37, 23, 19, 12, 59, 18, 52, 5, 17, 33, 7, 39,43, 58,41, and 10 were used. In set 8, genes 28, 68, 71,46, 48, 47, 5, 23, 22, 35, 60, 3, 40, 33, 41, 72, 12, 24, 15, 37, 1,20, 45, 53, 61,65, 74, 4, 10, 51, 26, 30, 38, 44, 55, 73, 66, 6, 39, 52, 36,2, 59, 67, 27, 43, 50, 18, 8, and 69 were used. In set 9, genes 73, 51,67, 63,24, 55, 42, 61,13, 29, 23,64,49, 53, 19,2,43, 11, 15, 31, 58, 40,38, 46,44,4,27,41,28, 69, 8, 26, 5,68, 37, 70,25, 62,22, 52, 1, 57, 54, 34, 16, 71, 9,65, 14, and 30 were used. In set 10, genes 9, 13, 46, 2, 62, 47, 50, 36, 58, 23, 55, 31,6, 40, 32, 27, 35, 33, 39, 1, 22, 19, 65, 16, 52, 72, 30, 3, 12, 7, 74, 21,54, 20,41, 10, 28, 37, 24, 53,69, 11, 14, 67, 25, 71, 15,42, 18, and 73 were used.

[0155] For 55 genes, set 1, genes 19, 3, 26, 44, 16, 59, 11, 39, 46, 54, 22, 7, 60, 30, 72, 6, 74, 53, 57, 14, 43, 47, 27, 45, 37, 24, 33, 64, 21, 36, 20, 50, 68, 62, 63,17, 61, 10, 70, 18, 25, 71,29, 65, 51,56, 58, 69, 5, 55, 12,1,40,49, and 13 were used. In set 2, genes 35, 15, 11,33, 5, 29, 73,69, 31, 70, 10,45,41, 72, 74, 26, 32, 12, 30,34, 16, 64, 13, 50,46, 38, 18,48, 37, 68,40, 61,62, 6, 63, 47, 36, 65, 17, 67, 71, 39, 4, 59, 22, 24, 8, 9, 58, 3, 52, 20, 14, 25, and 7 were used. In set 3, genes 7, 19, 50, 62, 47, 74, 22, 26, 37, 8, 41,53, 52, 67, 16, 40, 54, 34, 30, 46, 25, 55, 31, 3, 69, 38, 29, 65, 45, 43, 51, 68, 18, 57, 21, 5, 32, 20, 27, 73,66, 10,49,24, 12, 13, 11,71, 60,23,63, 35, 48, 39, and 70 were used. In set 4, genes 58, 70,43,68, 39, 57, 71,27, 21,53, 16, 23, 25, 60, 40, 36, 2, 63, 33, 49, 5, 54, 32, 66, 50, 59, 14, 52, 15, 48, 45, 44, 19, 72, 26, 10, 6, 41,34, 61,42, 67, 17, 24, 8, 11, 29, 74, 3, 51,47, 65, 69, 28, and 1 were used. In set 5, genes 60, 53, 21, 63, 7, 19, 69, 3, 9, 22, 10, 50, 59, 71,20, 11, 70, 6, 4, 17, 58, 16, 40, 68, 73, 38, 18, 15, 57, 26, 34, 67, 41, 27, 49, 28, 46, 54, 1, 13, 31,48, 32, 61,42, 66, 29, 5, 55, 72,25, 30, 39, 44, and 56 were used. In set 6, genes 4, 36, 17,47, 16, 6, 14, 51,65, 42, 31,38, 26, 15, 70, 28,41, 72, 30, 3, 29, 55, 34, 32, 54, 24,48, 39, 22, 57, 37,23, 71,61, 50, 21,27, 53, 25, 40, 20, 69, 58, 66, 46, 1,43, 12, 33, 63, 18, 68, 10, 56, and 45 were used. In set 7, genes 71,7, 38, 61, 22, 33, 51, 25, 68, 6, 1,49, 9, 58, 18, 55, 5, 50, 65, 52, 26, 59, 35, 11, 15, 70, 54, 27, 60, 28, 19, 63, 21, 10, 32, 42, 73, 36, 45, 66, 47, 2, 56, 23, 64, 44, 34, 29, 48, 69, 37, 16, 74, 53, and 43 were used. In set 8, genes 25, 42, 70, 28, 6, 48, 43, 20, 60, 18, 56, 74, 27, 9, 55, 67, 58, 68, 39, 38, 29, 1,21,45, 44, 66, 53, 34, 47, 64, 41,57, 10, 3, 31, 65, 54, 46, 50, 59, 23, 73, 24, 51, 36, 26, 16, 49, 37, 62, 7, 32, 19, 22, and 14 were used. In set 9, genes 49, 65,20, 59, 21,45, 54, 29, 51, 50, 17, 37, 55, 47, 57, 9, 8, 18, 11, 10, 25, 1,30, 68, 5, 6, 74, 70, 60, 53, 48, 39, 4, 23, 27, 73, 35, 40, 41,44, 24, 3, 58, 19, 14, 13, 33, 63, 62, 46, 2, 12, 72, 36, and 7 were used. In set 10, genes 73, 53, 26, 24, 58, 25, 59, 71,34, 65, 46, 2, 57, 48, 68, 21, 44, 22, 16, 70, 60, 8, 66, 45, 14, 27, 43, 37, 20, 36, 72, 18, 56, 4, 7, 6, 23, 15, 74, 1, 9, 50, 5, 35, 40, 32, 12, 38, 69, 33, 61, 62, 10, 47, and 39 were used.

[0156] For 60 genes, set 1, genes 49, 60, 66, 26, 22, 53, 33, 56, 10,44, 17, 36, 41, 6, 21,57, 39, 65, 24, 30, 31, 15,43, 68, 64, 59, 28, 73, 13, 18, 51, 34, 63, 40, 71, 58, 48, 11, 37, 42, 70, 45, 72, 3, 67, 35, 52, 46, 32, 55, 27, 38, 19, 25, 5, 69, 62, 14, 23, and 4 were used. In set 2, genes 57, 5, 31, 15, 20, 54, 21,42, 71,50, 17, 68, 61,53, 9, 35, 67, 12, 14, 52,41, 38, 22,45, 32, 39, 70, 18, 6, 26, 59, 40, 25, 28, 56, 10, 3, 47, 34, 8, 60, 2, 9, 62, 66, 19, 11, 37, 27, 36, 69, 7, 65, 4, 33, 24, 51, 55, 48, amd 44 were used. In set 3, genes 37, 54, 44, 66, 36, 1,61,62,47, 69,4, 30, 31, 11, 8, 63, 38, 16, 65, 25, 74, 21, 34, 60, 20, 71, 12, 19, 43, 15, 27, 57, 6, 55, 64, 22, 14, 39, 53, 23, 17, 28, 51, 56, 40, 29, 58, 48, 42, 59, 68, 5, 35, 50, 72, 10, 45, 32, 33, and 73 were used. In set 4, genes 24, 2, 49, 57, 35, 45, 40, 51,42, 7, 47, 5, 8, 17, 61, 74, 64, 72, 50, 60, 70, 26, 9, 56, 32, 4, 16, 44, 27, 43, 53, 33, 46, 55, 41, 68, 48, 11, 10, 39, 19, 6, 3, 14, 65, 69, 30, 34, 29, 36, 58, 28, 1,23, 73, 15, 25, 13, 54, and 18 were used. In set 5, genes 18, 28, 1,22, 71,37,62,46,31,25, 70,64,66, 35, 5, 60, 10, 26, 9,43, 67, 20, 59, 51, 33,42, 3, 24,49, 13, 27, 38, 61, 14, 52, 63, 11, 74, 7, 16, 23, 72, 39, 73, 15, 6, 17, 30, 57, 8, 50, 48, 34, 53, 2, 69, 29, 56, 44, and 47 were used. In set 6, genes 33, 74, 12, 7,49, 25, 38, 1,8, 4,48, 26, 58, 54, 21,50, 72,45, 62, 66, 36, 13, 42, 5, 39, 17, 28, 23, 67, 41,29, 73, 19, 56, 51,69, 10, 16, 55, 14, 24, 64, 22, 59, 52, 35, 2, 31, 3, 9, 27, 71,30, 32, 53, 11,40, 61, 15, and 70 were used. In set 7, genes 30, 65, 26,48, 47, 20, 17, 56, 35, 32, 10, 11, 1,59, 50, 53, 45, 13, 63,49,41, 74, 16, 57, 15, 64, 12, 54, 5, 8, 67, 69, 31, 14, 61, 60, 37, 66, 43, 71,23, 36, 51, 44, 34, 2, 42, 19, 58, 25, 27, 68, 18, 52, 21,7, 70, 22, 28, and 62 were used. In set 8, genes 12, 58, 11, 5, 72, 70, 63, 66, 49, 44, 14, 48, 26, 73, 51,47, 13, 65, 1,39, 61, 17, 40, 8, 24, 54, 42, 34, 64, 21, 53, 59, 46, 4, 20, 29, 57, 74, 31, 67, 6, 69, 7, 68, 41,3, 18, 62, 19, 32, 10, 43, 36, 71, 28, 60, 30, 15, 23, and 52 were used. In set 9, genes 7, 20, 69, 12, 58, 40, 70, 57, 3, 37, 6, 16, 61, 11, 13, 31, 55, 17, 49, 22, 36, 47, 44, 18, 45, 68, 25, 72, 19, 14, 39, 46, 30, 59, 56, 5, 66, 2, 41, 51,9, 54, 35, 15, 26, 27, 23, 65, 4, 63, 1, 60, 21, 74, 24, 43, 38, 64, 50, and 67 were used. In set 10, genes 5, 43, 54, 22,49, 48, 25, 24, 52, 35, 14, 70, 26, 72, 59, 71, 9, 41, 74, 36, 17, 47, 29, 34, 20, 27, 65, 68, 3, 73, 45, 62, 57, 56, 53, 44, 6, 7, 31, 55, 30, 23, 15, 33,38, 42, 10,60,66, 8, 1,64, 19, 16, 12,61,63, 51, 18, and 2 were used.

[0157] For 65 genes, set 1, genes 11, 10, 1, 69,43, 33, 54, 24, 39, 27,42, 18, 9, 46, 12, 20, 61,44, 51, 64, 35, 8, 36, 38, 21, 7, 57, 59, 23, 49, 17, 15, 22, 55, 29, 16, 37, 72, 30, 31,45, 63, 40, 28, 41, 32, 66, 65, 5, 47, 53, 60, 25, 50, 74, 52, 14, 68, 48, 13, 2, 4, 3, 6, and 67 were used. In set 2, genes 37, 8, 31,4, 23, 57, 69,40, 3, 9, 5, 32, 42,44, 56, 21, 10, 34, 74, 61, 39, 38, 13, 70, 41, 19,48, 47, 29, 52, 26, 72,49,45, 7, 63, 16, 25, 24, 14, 18, 60, 59, 11,35, 2, 30, 68, 58, 67, 27, 33, 66, 12, 71,51,55, 6, 20, 54, 1,46, 64, 62, and 53 were used. In set 3, genes 24, 19, 35, 57, 27, 8, 23, 30, 65, 32, 59, 29,4, 47, 17, 53, 34, 54, 73, 14, 20, 63, 43, 3, 38, 61, 31,49, 25, 42, 41, 51, 18, 7, 40, 39, 33, 50, 70, 28, 13, 74, 36, 45, 64, 5, 16, 58, 1, 66, 62, 46, 15, 12, 72, 21, 2, 68, 71, 9, 44, 26, 37, 6, and 55 were used. In set 4, genes 62, 29, 5,41, 18,4, 21, 63, 65, 8, 55, 61,66, 34, 23, 28, 14,49, 68, 15, 1,11, 19, 73, 13, 57, 20, 27, 50, 2, 72, 22, 6, 7, 40, 67, 51, 45, 10, 36, 53, 64, 54, 24, 25, 37, 74, 12, 52, 26, 38, 32, 3, 30, 33, 39, 48, 58, 17, 42, 71,43, 69, 56, and 9 were used. In set 5, genes 49, 58, 74, 65, 67, 44, 57, 28, 56, 18, 59, 31, 10, 17, 41, 39, 63, 7, 21,55, 38, 2, 51,42, 5, 53, 20, 34, 16, 43, 19, 15, 50, 4, 6, 11, 52, 37, 8, 64, 69, 12, 48, 60, 1, 66, 27, 36, 45, 30, 14, 72, 68, 73, 35, 47, 71, 22, 70, 33, 32, 46, 25, 13, and 54 were used. In set 6, genes 7, 44, 23, 68, 46, 30, 10,4, 3, 53, 22, 38, 50, 26.55.49.20, 11,73, 12,62,63,43,69,6,61,52,25, 65, 16, 47, 34,33,28,42,58,29,39,31, 1,36, 13,5, 60,35, 19,40, 18, 59, 64, 41, 70, 72, 57, 67, 9, 74, 8, 14, 71,45, 56, 32, 51, and 2 were used. In set 7, genes 57, 61, 9,48, 31,4,40, 35, 1, 16, 44, 67, 68, 34, 6, 64, 7, 54, 53, 10, 18, 39, 23, 14, 33, 74, 51, 38, 24, 19, 72, 63, 36, 65, 32, 2, 27, 45, 3, 43, 21,49, 30, 60, 50, 70, 41.20, 11,37, 13, 15, 5, 12, 46, 26, 22, 71, 8, 62, 29, 28, 25, 17, and 52 were used. In set 8, genes 11,21, 3, 6, 74, 58, 52, 40, 17, 23, 41,63, 22, 56, 55, 8, 60, 54, 51, 57, 66, 68, 29, 24, 69, 39, 16, 49, 72, 59, 48, 61,2, 7, 44, 37, 43, 45, 35, 25, 1, 4, 20, 14, 36, 42, 65, 62, 71,32, 19, 70, 28, 27, 9, 46, 33, 18, 67, 15, 30, 26, 12, 47, and 53 were used. In set 9, genes 48, 27, 64, 55, 30, 2, 33, 16, 31,21, 57, 50, 63, 17, 44, 29, 4, 6, 60, 65, 23, 19, 58, 68, 25, 59, 14, 7, 42, 12, 69, 45, 53, 73, 56, 34, 41, 3, 18, 5, 72, 70, 40, 37, 62,43, 51, 24, 52, 20, 39, 8, 13, 26, 10, 66, 54, 22, 49, 61, 11,46, 32, 67, and 36 were used. In set 10, genes 31, 39, 50, 60, 17, 33, 73, 30, 3, 27, 10, 62, 29, 12, 59, 1, 34, 69, 51, 72, 65, 52, 16, 36, 28, 23, 42, 40, 66, 58, 48, 46, 38, 74, 20, 55,21,49,63, 2, 70, 7, 26, 53,41,45, 25, 44, 71,32,24, 13, 14,6, 57, 11,68, 35, 54,22,64,8, 9, 56, and 37 were used.

[0158] For 70 genes, set 1, genes 72, 74, 31,73, 52, 16, 32, 24, 14, 66, 59, 28, 54, 1, 11, 12, 34, 57, 5, 67, 25, 42, 62, 71, 68, 69, 48, 7, 18, 20, 47, 19, 53, 2, 4, 15, 26, 63, 37, 17, 10, 60, 65, 8, 22, 70, 36, 30, 41, 9, 21, 35, 49, 38, 33, 56, 46, 27, 45, 44, 39,43, 29, 50, 61,40, 23, 64, 55, and 3 were used. In set 2, genes 45, 32, 60, 2,42, 56, 8,46, 30, 27, 17, 62, 26, 24, 65, 49, 16, 70, 3, 47, 50, 4,40, 28, 1, 36, 22, 59,48, 9, 57, 5, 72, 23, 13,44, 67, 14, 12, 34, 21,41,71,39, 66, 25, 69, 19, 15, 6, 68, 29, 52, 43, 64, 58, 54, 11, 37, 38, 55, 7, 20, 61,53, 63, 10, 74, 51, and 35 were used. In set 3, genes 66, 71, 40, 62, 60, 51, 61, 5, 19, 15, 34, 13, 18, 8, 28, 59, 35, 54, 2, 55, 29, 22, 41,37, 45, 64, 48, 7, 73, 27, 30, 69, 63, 23, 25, 42, 1,24, 14, 38, 4, 70, 53, 3, 36, 12, 74, 68, 26, 57, 33, 17, 67, 72, 52, 58, 46, 39, 43, 56, 65, 10, 44, 11, 20, 47, 50, 9, 21, and 49 were used. In set 4, genes 73, 26, 33, 40, 71,50, 62, 59, 10, 39, 64, 68, 3, 1, 44, 9, 72, 57, 43, 37, 24, 65, 48, 6, 11,23, 36, 19, 7, 31,67, 69, 38, 29, 16, 35, 63, 21,46, 15, 47, 28, 2, 5, 52, 70, 14, 22, 56, 45, 17, 4, 25, 66, 13, 55, 20, 30, 32, 54, 51,49, 58, 74, 42, 53, 61,34, 12, and 60 were used. In set 5, genes 7, 1, 24, 70, 26, 35, 68, 71, 74, 33, 5, 20, 49, 27, 65, 10, 72, 21, 66, 12, 4, 43, 9, 55, 23, 56, 47, 31, 42, 59, 61,45, 67, 13, 63, 58, 17, 54, 28, 3, 64, 53, 39, 36, 30, 40, 37, 16, 41, 11, 52, 14, 62, 8, 46, 25, 44, 69, 29, 48, 51,22, 73, 57, 18, 15, 19, 38, 6, and 50 were used. In set 6, genes 41, 36, 1, 27, 9, 51,4, 38, 8, 25, 73, 5, 7, 22, 68, 30, 6, 33, 65, 70, 21,26, 60, 62, 63, 54, 57, 74, 58, 44, 11, 31, 53, 34, 10, 48, 23, 3, 42, 35, 49, 13, 71, 17, 50, 28, 19, 20, 40, 64, 56, 43, 69, 59, 39, 66, 72, 46, 32, 2, 14, 47, 52, 45, 15, 37, 12, 16, 24, and 67 were used. In set 7, genes 39, 70, 16, 5, 43, 6, 36, 30, 9, 53, 2, 34, 72,42, 64, 73, 56, 63, 38, 13, 19, 27, 29, 60, 37, 52, 1,3, 21, 22, 68, 69, 26, 55, 61, 11, 18, 12,45, 8, 51, 65, 32, 33, 67, 48, 50, 10, 20, 28, 58, 7, 49, 35, 57, 71, 23, 17, 24, 62, 59, 54, 15, 40, 14, 41,47, 46, 44, and 4 were used. In set 8, genes 3, 5, 50, 35, 53, 57, 14, 49, 55, 8, 25, 22, 71, 60, 13, 19, 12, 32, 26, 44, 15, 39, 17, 31, 61, 23, 66, 68, 4, 6, 7, 41, 24, 40, 58, 67, 46, 70, 45, 64, S1,69, 18, 62, 47, 52, 11, 30, 73, 28, 33, 2, 36, 1,72, 42, 20, 27, 10, 16, 63, 38, 59, 74, 43, 9, 56, 34, 21, and 65 were used. In set 9, genes 18, 49, 70, 46, 29, 9, 52, 53, 64, 28, 37, 27, 7, 57, 44, 19, 72, 61, 67, 30, 62, 47, 2, 39, 8, 65, 26, 14, 63, 4, 20, 59, 45, 15, 10, 3, 16, 58, 25, 38, 60, 71, 66, 32, 23, 55, 69, 12, 33, 6, 42, 36, 22, 48, 24, 68, 41, 17, 54, 13, 21, 51, 73, 74, 40, 43, 1, 11, 56, and 35 were used. In set 10, genes 14, 12, 65, 74, 58, 6, 36, 5, 34, 11, 18, 33, 32, 7, 22, 37, 64, 59, 9, 52,41, 26, 3, 19, 48, 35, 56, 62, 42, 60, 1, 8, 43, 50, 25, 61, 54, 49, 20, 70, 44, 30, 15, 46, 72, 38, 4, 29, 68, 21, 39, 17, 16, 53, 45, 73, 63, 31, 55, 47, 24, 69, 2, 71, 13, 28, 66, 23, 57, and 40 were used.

[0159] A similar experiment was performed with random subsets of 50 to all members of the set of 90 expressed gene sequences. Again, the expression levels of random combinations of 50, 55, 60, 65, 70, and all 90 (each combination sampled 10 times) of the 90 expressed sequences were used with data from tumor types and then used to predict test random sets of tumor samples (each sampled 10 times) ranging from 2 to all 39 types. The resulting data are shown in Figures 6 and 7.

[0160] The members of the 90 gene sequences were indexed from 1 to 90, and representative random sets used in the invention are as follows: [0161] For 50-genes, set 1, genes 89, 30, 62, 23, 31, 20, 53, 25, 15, 38, 11, 22, 68, 44, 58, 7, 14, 61, 67, 32, 18, 71, 9, 54, 46, 3, 57, 50, 59, 79, 48, 90, 82, 64, 39, 21, 60, 37, 47, 10, 52, 77, 33, 45, 35, 83, 16, 69, 74, and 27 were used. In set 2, genes 25, 17, 64, 82, 23, 5, 77, 48, 72, 63, 34, 60, 61, 35, 58, 19, 56, 83, 8, 13, 38, 89, 59, 62, 88, 71, 11, 29, 31, 68, 65, 67, 78, 44, 27, 81,24, 1, 18, 55, 85, 46, 41, 14, 84, 26, 16, 21, 12, and 69 were used. In set 3, genes 24, 39, 35, 15, 49, 44, 28, 58, 20, 3, 88, 23, 54, 31, 33, 37, 62, 25, 87, 75, 17, 41, 21, 19, 38, 85, 86, 74, 8, 12, 77, 30, 27, 43, 76, 73, 9, 14, 6, 63, 64, 81, 26, 66, 2, 56, 34, 60, 57, and 61 were used. In set 4, genes 40, 71, 55, 63, 2, 13, 38, 58, 26, 18, 76, 74, 17, 67, 69,4, 9, 20, 21, 10, 35, 70, 49, 37, 12, 77, 61,60, 15, 7, 36, 89, 33, 59, 78, 39, 82, 16, 64, 28, 6, 66, 52, 5, 44, 73, 34, 75, 31, and 29 were used. In set 5, genes 16, 37, 57, 18, 29, 66, 54, 6, 44, 70, 20, 65, 5, 61, 72, 83, 85, 58, 87, 73, 23, 76, 25, 68, 49, 24, 79, 89, 55, 75, 47, 19, 33, 39, 21,63, 84, 32, 77, 40, 12, 11,42, 50, 1, 9, 78, 3, 74, and 7 were used. In set 6, genes 42, 29, 74, 68, 27, 54, 15, 63, 30, 51, 78, 56, 82, 66, 80, 79, 90, 64, 22,44, 71,2, 89, 39,46, 52, 36, 32, 84, 6, 59, 9, 38, 4, 55, 19, 7, 60, 49, 23, 73, 5, 11, 50, 70, 34, 61, 81,67, and 28 were used. In set 7, genes 31, 27, 24, 75, 7, 46, 40, 60, 51, 37, 87, 28, 67, 62, 50, 66, 61, 63, 49, 1, 39, 74, 81,4, 52, 22, 79, 45, 12, 41, 15, 90, 26, 33, 78, 48, 83, 10, 53, 73, 6, 19, 71, 59, 68, 56, 64, 13, 32, and 30 were used. In set 8, genes 88, 57, 5, 4, 1,43, 12, 32, 66, 81, 90, 19, 51, 18, 55, 9, 29, 75, 11, 73, 23, 61, 6, 79, 69, 60, 13, 62, 8, 71, 2, 52, 67, 59, 87, 33, 80, 21, 14, 89, 39, 65, 56, 38, 47, 31, 84, 25,45, and 41 were used. In set 9, genes 60, 45, 51,32, 49, 2, 44, 66, 83, 50, 87, 1, 90, 28, 42, 85, 13, 40, 70, 82, 79, 89, 64, 63, 27, 52, 10, 86, 77, 15, 56, 8, 33, 53, 38, 46, 67, 19, 68, 29, 48, 21, 34, 61, 18, 55, 25, 35, 39, and 80 were used. In set 10, genes 80, 39, 23, 76, 87, 33, 30, 88, 85, 89, 24,47, 44,43, 48, 55, 14, 73, 22, 19, 67, 1, 42, 51,60, 12, 9, 6, 75, 17, 40, 25, 28, 74, 38, 66, 5, 50, 8, 37, 15, 29, 21, 11,35, 31, 13, 36, 52, and 18 were used.

[0162] For 55 genes, set 1, genes 86, 47, 80, 15, 74, 20, 79, 35, 14, 49, 41, 2, 48, 30, 81, 65, 5, 24, 51, 10, 31, 68, 7, 21, 28, 37, 38, 4, 18, 23, 44, 77, 42, 19, 61,27, 75, 67, 36, 22, 26, 50, 32, 58, 71, 57, 76, 1, 66, 72, 33, 6, 34, 59, and 13 were used. In set 2, genes 73, 88, 39, 52, 87, 78, 84, 1,42, 69, 62, 58, 10, 51, 38, 14, 77, 49, 36, 35, 34, 15, 65, 60, 20, 17, 61, 2, 59, 22, 81, 11, 19, 41, 5, 29, 12, 43, 7, 4, 64, 40, 74, 48, 72, 54, 68, 86, 66, 6, 67, 89, 21, 16, and 9 were used. In set 3, genes 28, 89, 35, 86, 49, 56, 69, 18, 15, 27, 13, 6, 51, 77, 8, 80, 16, 78, 43, 29, 37, 20, 9, 31,32, 67, 48, 65, 82, 62, 76, 25, 54, 41, 90, 47, 2, 71, 87, 84, 57, 74, 61, 59, 85, 75, 10, 66, 46, 73, 24, 44, 14, 4, and 7 were used. In set 4, genes 48, 76, 17, 62, 65, 87, 19, 24, 83, 29, 55, 12, 68, 82, 73, 18, 20, 10, 81, 53, 33, 56, 34, 5, 60, 46, 16, 25, 2, 42, 6, 49, 4, 45, 88, 32, 77, 8, 1, 71, 3, 27, 72, 59, 79, 64, 11,80, 57, 61, 75, 39, 23, 52, and 37 were used. In set 5, genes 54, 77, 74, 76, 81, 17, 25, 57, 29, 36, 55, 75, 66, 15, 2, 41, 37, 59, 12, 45, 4, 9, 69, 18, 49, 22, 42, 62, 10, 52, 48, 31,44, 19, 79, 50, 40, 32, 89, 87, 11, 5, 73, 20, 80, 35, 70, 53, 83, 72, 88, 47, 84, 39, and 65 were used. In set 6, genes 86, 43, 75, 90, 32, 85, 38, 54, 87, 42, 73, 55, 27, 34, 11,14, 65, 82, 77, 21,26,46, 83, 10, 15, 22, 66, 20, 67, 72, 35, 68, 3, 53, 44, 50, 70, 40, 30, 31, 84, 81, 62, 51, 80, 79, 59, 57, 88, 69, 2, 64, 23, 28, and 16 were used. In set 7, genes 76, 15, 53, 8, 89, 52, 20, 3, 47, 83, 45, 31, 80, 82, 4, 57, 65, 41, 29, 77, 46, 60, 24, 33, 70, 37, 12, 66,42, 61, 63, 86, 30, 11,40, 27, 39, 56, 9, 49, 35, 22, 10, 48, 18, 68, 58, 62, 34, 85, 84, 26, 43, 81, and 38 were used. In set 8, genes 3, 46, 11, 89, 63, 61,26, 69, 47, 82, 27, 39, 52, 2, 70, 6, 41, 14, 36, 30, 65, 74, 28, 34, 42, 79, 59, 4, 72, 37, 66, 50, 45, 23, 73, 71, 10, 19, 78, 62, 20, 5, 56, 25, 75, 38, 13, 86, 88, 22, 32, 58, 60, 1, and 51 were used. In set 9, genes 16, 61, 85, 3, 42, 24, 55, 4, 9, 22, 28, 31, 53, 74, 25, 52, 10, 49, 2, 21, 30, 78, 54, 26, 38, 87, 35, 37, 45, 84, 83, 57, 64, 65, 68, 50, 1, 34, 75, 67, 60, 5, 7, 58, 59, 76, 27, 77, 44, 32, 6, 11,48, 56, and 15 were used. In set 10, genes 72, 86, 46, 5, 3, 29, 54, 66, 20, 44, 41,47, 14,65, 83, 56, 43, 26,49,48, 69,24,45, 27, 73, 11,40, 22, 78, 2, 39, 15, 31,35, 77, 61, 9, 52, 37, 1,89, 79, 60, 18, 50, 17, 88, 80, 57, 71, 12, 53, 36, 58, and 42 were used.

[0163] For 60 genes, set 1, genes 75, 54, 79, 78, 4, 48, 36, 29, 28, 32, 82, 38, 21,8, 80, 46, 47, 57, 76, 50, 18, 68, 85, 13, 61, 65, 71,56, 45, 58, 84, 25, 72,43, 7, 77, 74, 69, 86, 31, 19, 63, 35,83, 70, 3, 62, 90, 52, 87,44,41,66, 12,23, 59, 1, 10,49, and 67 were used. In set 2, genes 6, 50, 10, 38, 29, 59, 60, 12, 74, 14, 65, 61, 54, 2, 89, 68, 9, 62, 20, 81, 70, 67, 66, 52, 45, 58, 43, 31, 86, 79, 82, 1, 42, 88, 85, 22, 87, 84, 24, 21, 5, 39, 25, 51,40, 63, 49, 7, 35, 36, 71, 90, 47, 15, 56, 23, 83, 34, 76, and 19 were used. In set 3, genes 17, 68, 41,53, 15, 58, 90, 21, 10, 61,72, 44, 22, 8, 32, 47, 55, 48, 45, 3, 5, 7, 1,4, 24, 49, 75, 54, 39, 57, 19, 70, 79, 66, 6, 60, 51, 56, 46, 14, 85, 80, 36, 31, 37, 86, 42, 84, 87, 23, 2, 81, 11, 50, 40, 52, 13, 65, 62, and 76 were used. In set 4, genes 54, 24, 50, 11,77, 63, 84, 71, 16, 51, 78, 83, 10, 28, 31,29,43, 14, 30, 61, 81, 58,4,48,64, 37, 18, 39, 1, 67, 45, 40, 80, 79, 8, 55, 36, 2, 32, 25, 21,46, 73, 38, 34, 52, 49, 65, 13, 66, 6, 76, 20, 85, 15, 44, 60, 69, 86, and 88 were used.

In set 5, genes 89, 22, 12, 82, 28, 14, 87, 8, 79, 48, 69, 84, 66, 43, 88, 13, 9, 50, 75, 71,20, 36, 5, 54, 80, 62, 4, 23, 24, 60, 19, 10, 63, 81,68, 30, 32, 52, 56, 37, 15, 83, 16, 90, 26, 44, 78, 39, 61, 59, 45, 74, 58, 86, 35, 33, 47, 57, 18, and 42 were used. In set 6, genes 41,38, 76, 54, 12, 29, 66, 35, 68, 80, 64, 57, 46, 25, 27, 49, 86, 36, 20, 5, 16, 19, 69, 59, 48, 4, 10, 70, 17, 60, 50, 63, 18, 33,65, 39, 23, 82, 51, 55, 8, 28, 53, 84, 67, 22, 71, 77, 13, 9,42,21,62, 31,78, 11,89, 45, 52, and 74 were used. In set 7, genes 84, 12, 17, 10, 33, 56, 50, 61, 74, 21, 78, 11, 37, 36, 3, 5, 30, 43, 47, 54, 27, 32, 77, 51,42, 4, 76, 71, 83, 46, 57, 73, 87, 24, 90, 8, 72, 29, 35, 66, 28, 70, 22, 39, 65, 85, 1,82, 40, 89, 80, 58, 52, 38, 59, 86, 69, 13, 16, and 14 were used. In set 8, genes 71, 3, 44, 6, 16, 69, 34, 20, 56, 72, 5, 68, 9, 52, 49, 58, 79, 76, 2, 59, 7, 73, 51, 74, 19, 88, 60, 30, 61, 13, 89, 50, 31,40, 81, 10, 21, 54, 45, 77, 67, 36, 46, 1,43, 83, 55, 12, 80, 28, 41, 86, 47, 39, 53, 17, 78, 63, 87, and 48 were used. In set 9, genes 47, 30, 10, 11,39, 23,41, 29, 21, 36, 45,49, 69, 1, 24, 66, 57, 12, 56, 22, 71,9, 89, 52, 83, 28, 80, 37, 72, 67, 76, 87, 82, 5, 88, 4, 3, 68, 58, 64, 62, 46, 74, 7, 20, 15, 48, 53, 54, 63, 19, 13, 43, 32, 51, 31, 33, 27, 35, and 40 were used. In set 10, genes 75, 29, 27, 66, 15, 47, 14, 3, 12, 80, 31, 32, 41, 17, 74, 7, 57, 59, 64, 25, 13, 77, 33, 43, 81, 55, 48, 68, 30, 54, 69, 88, 62, 86, 67, 37, 20, 8, 42, 19, 70, 24, 49, 73, 23, 10, 1,85, 89, 44, 58, 2, 11, 63, 76, 5, 53, 83, 50, and 9 were used.

[0164] For 65 genes, set 1, genes 55, 36, 14, 26, 67, 60, 28, 31,46, 85, 16, 10, 17, 45, 73, 87, 7, 72, 90, 4, 84, 34, 78, 19, 71, 54, 29, 43, 76, 12, 35, 61,49, 57, 89, 20, 50, 47, 86, 88, 59, 75, 15, 8, 5, 3, 32, 81, 74, 23, 41, 13, 33, 63, 77, 22, 9, 38, 64, 69, 80, 25, 1, 18, and 30 were used. In set 2, genes 32, 81, 5, 65, 79, 12, 52, 83, 2, 39, 19, 37, 44, 66, 63, 72, 56, 60, 3, 22, 70, 64, 9, 67, 15, 8, 50, 48, 71, 82, 76, 14, 28, 18, 25, 11, 29, 58, 35, 31, 10, 69, 38, 90, 80, 74, 53, 75, 4, 77, 89, 55, 57, 59, 51,42, 41, 68, 23, 84, 45, 40, 20, 85, and 61 were used. In set 3, genes 33, 52, 22, 67, 7, 36, 40, 6, 56, 29, 48, 41, 28, 68, 83, 90, 51, 70, 60, 24, 87, 88, 18, 58, 73, 1, 17, 8, 26, 89, 38, 4, 10, 47, 75, 72, 50, 13, 23, 66, 20, 30, 12, 43, 46, 15, 16, 5, 55, 31, 63, 32, 53, 69, 39, 71,42, 62, 57, 34, 44, 14, 25, 64, and 80 were used. In set 4, genes 30, 45, 74, 3, 13, 63, 76, 27, 46, 11, 51,2, 20, 78, 66, 65, 43, 7, 69, 40, 28, 19, 25, 52, 26, 34, 49, 44, 60, 59, 38, 48, 85, 87, 18, 82, 15, 42, 24, 67, 61, 71, 70, 35, 68, 79, 47, 83, 80, 84, 31,32, 9, 77, 72, 62, 8, 55, 54, 1, 58, 16, 53, 89, and 90 were used. In set 5, genes 14, 55, 53, 45, 32, 63, 49, 15, 10, 11, 47, 52, 3, 13, 71,68, 85, 34, 66, 64, 83, 78, 28, 21, 30, 54, 29, 88, 59, 73, 26, 84, 50, 77, 65, 82, 20, 86, 19, 57, 62, 25, 43, 27, 8, 6, 87, 38, 51,61,56, 2,18,46,44, 80, 9, 31, 36, 76,1, 7, 33,48, and 58 were used. In set 6, genes 66,44, 18, 85, 54, 28, 80, 65,25, 1,88, 72, 74,46, 76, 71,24, 51,47, 31,21,60,83, 32, 3, 63, 64,69, 52, 27,2, 38, 34, 10, 12, 35, 77, 33,29, 56, 67,40, 30, 22, 49, 5, 7, 43, 17, 13, 81,20, 79, 14, 48, 73, 53, 90, 70, 59, 19, 16, 8, 36, and 23 were used. In set 7, genes 89, 37, 48, 32, 75, 46, 90, 2, 66, 44, 55, 17, 9, 59, 68, 83, 24, 53, 19, 67, 74, 35, 72, 4, 13, 76, 15, 62, 63, 28, 51, 26, 39, 20, 18, 45, 36, 78, 41, 84, 87, 11, 80, 12, 81, 3, 50, 86, 6, 61, 73, 31, 27, 88, 42, 71, 33, 43, 60, 30, 69, 34, 21,49, and 70 were used. In set 8, genes 84, 73, 14, 23, 36, 47, 31, 61, 57, 50, 78, 53, 90, 68, 37, 39, 75, 4, 10, 80, 35, 32, 85, 18, 81,29, 66, 76, 54, 41,62, 30, 58, 49, 33, 64, 45, 87, 25, 79, 20, 69, 42, 17, 88, 24, 2, 34, 16, 28, 86, 15, 7, 82, 1, 60, 11,48, 89, 22, 77, 74, 72, 6, and 43 were used.

In set 9, genes 1, 74, 39, 48, 44, 47, 3, 8, 80, 54, 16, 41, 76, 9, 85, 86, 49, 70, 52, 89, 19, 66, 43, 17, 15, 63, 29, 53, 42, 32, 30, 4, 36, 7, 77, 2, 84, 87, 28, 67, 20, 56, 65, 31, 12, 25, 40, 10, 73, 6, 83, 64, 50, 13, 22, 58, 45, 21, 57, 60, 72, 82, 26, 33, and 35 were used. In set 10, genes 18, 31, 52, 70,48, 76, 57, 66, 10, 14, 60, 30,67, 45, 35, 51, 1,79, 46, 71,3, 42, 33,85,4, 61,2,63, 87, 50, 36, 37, 90, 80, 24, 6, 77, 28, 21,88, 17, 82, 83, 49, 75, 54, 25, 5, 7, 73, 59, 29, 69, 47, 65, 19, 15, 56, 9, 55, 58, 40, 20, 89, and 74 were used.

[0165] For 70 genes, set 1, genes 79, 50, 38, 63, 74, 71,66, 4, 33, 1,69, 88, 85, 18, 27, 77, 70, 65, 14, 40, 64, 29, 59, 6, 3, 9, 84, 22, 62, 60, 30, 7, 11, 13, 45, 57, 35, 72, 15, 75, 39, 36, 10, 53, 67, 80, 83, 31,5, 25, 90, 89, 58, 23, 56, 2, 16, 41, 76, 47, 26, 43, 17, 55, 82, 87, 24, 12, 48, and 81 were used. In set 2, genes 6, 66, 68, 83, 77, 81,21,88, 18, 60, 50, 17, 13, 61, 14, 25, 39, 76, 75, 78, 89, 37, 87, 59, 55, 90, 9, 5, 12, 10, 43, 29, 51, 31,46, 58, 49, 24, 52, 28, 64, 42, 8, 11,67, 84, 70, 19, 41,45, 71, 16, 33, 23, 34, 30, 86, 69, 4, 57,47, 80, 20, 82, 2, 1, 56, 65, 62, and 48 were used. In set 3, genes 72, 87, 89, 53, 56, 17, 84, 60, 45, 61.62, 76, 13, 37, 20,21,2,23, 3, 57, 83, 90,82,49, 24, 59, 9,48, 32,33,47,42, 78, 88, 65, 52, 79,41,34, 19, 74,66,43,27, 36, 63, 81,44,40, 80, 31,86, 12, 29, 77, 67, 14, 71, 68, 1,35, 16, 10, 30, 6, 22, 75, 55, 85, and 4 were used. In set 4, genes 70, 81,71, 17, 8, 59, 6, 15, 52, 74, 23, 9, 19, 14, 82, 86, 27, 73, 66, 38, 22, 41,88, 76,47, 58, 56, 11, 55, 64,44, 84, 62, 21, 35, 80, 36, 28, 12, 13, 4, 1, 75, 60, 5, 87, 89, 2, 50, 46, 25, 85, 37, 90, 78, 34, 24, 18, 45, 79, 77, 30, 32, 51, 57, 67, 83, 68, 54, and 29 were used. In set 5, genes 70, 23, 22, 30, 85, 48, 21, 32, 86, 84, 78, 87, 64, 40, 4, 34, 67, 19, 25, 7, 55, 42, 65, 53, 49, 83, 50, 80.62, 16, 37, 77, 71, 54,28, 27,29, 18, 13, 57, 79, 56, 15, 36, 5, 24, 3, 1,75, 90, 73,47, 51, 88, 38, 58, 66,81,35, 76,43,46, 82, 68, 10, 14, 8, 41, 39, and 59 were used. In set 6, genes 88, 3, 40, 60, 24, 43, 62, 85, 58, 53, 39, 56, 59, 81, 71, 63, 25, 16, 22, 14, 10, 72, 89, 90, 84, 5, 33, 12, 45, 57, 70, 38, 32, 19, 44, 46, 2, 64, 8, 49, 42, 27, 37, 29, 13, 6, 28, 7, 77, 41, 17, 50, 31, 69, 26, 83, 23, 73, 80, 51, 61, 76, 82, 18, 15, 78, 67, 54, 36, and 65 were used. In set 7, genes 35, 52,48, 42, 65, 38, 61, 79, 23, 20, 12, 8, 53, 57, 22, 54, 69, 9, 56, 43, 5, 66, 86, 49, 81, 19, 40, 45, 85, 60, 10, 50, 55, 11, 15, 73, 13, 2, 29, 59, 78, 67, 18, 80, 84, 39, 87, 90, 58, 46, 17, 32, 7, 62, 14, 34, 27, 6, 83, 70, 51, 26, 68, 21, 82, 77, 44, 47, 24, and 37 were used. In set 8, genes 40, 55, 22, 47, 86, 19, 62, 51,25, 59, 8, 65, 48, 79, 1, 66, 17, 70, 32, 49, 23, 61,85, 28, 36, 54, 20, 39, 83, 73, 50, 4, 81,27, 41, 63, 15, 80, 87, 7, 46, 33, 9, 68, 56, 77, 14, 75, 82, 74, 12, 37, 16, 84, 72, 30, 2, 38, 13, 57, 76, 5, 64, 45, 89, 58, 29, 10, 78, and 90 were used. In set 9, genes 84, 16, 21,81, 89, 60, 79, 30, 47, 69, 83, 85, 75, 52, 49, 72, 86, 3, 9, 59, 18, 55, 17, 82, 14, 23, 38, 24, 87, 65, 77, 80, 66, 19, 41, 53, 1,34, 27, 56, 40, 67, 32, 20, 37, 70, 36, 15, 22, 8, 29, 48, 58, 45, 25, 71, 7, 4, 73, 10, 12, 2, 42, 90, 63, 43, 51, 6, 54, and 78 were used. In set 10, genes 19, 51, 29, 22, 66, 13, 32, 89, 62, 45, 65, 35, 24, 73, 55, 47, 67, 76, 69, 26, 37, 64, 53, 10, 15, 34, 79, 2, 56, 30, 3, 20, 78, 31, 75, 46, 27, 52, 6, 86, 16, 9, 54, 87, 58, 33, 61, 11,43, 40, 74, 60, 50, 25, 80, 72, 83, 57, 38, 1,70, 5, 7, 77, 85, 59, 88, 63, 14, and 84 were used.

[0166] For 75 genes, set 1, genes 87, 17, 52,44, 57, 53, 78, 37, 2, 71, 9, 68, 6, 63, 50, 58, 13, 26, 16, 60, 67, 3, 32, 21,79, 12, 77, 73, 24, 35, 80, 47, 29, 40, 30, 84, 39, 90, 11, 81, 75, 76, 89, 66, 86, 42, 34, 64, 54, 7, 41, 56, 62, 55, 46, 28, 5, 25, 27, 83, 19, 20, 49, 69, 85, 33, 18, 23, 74, 1,10, 43, 22, 8, and 45 were used. In set 2, genes 75, 33, 52, 86, 24, 50, 70, 10, 17, 90, 28, 46,48, 77,47, 61, 12,4, 83, 27,45, 88, 35, 36, 22, 68, 73, 31,57, 69, 65, 64, 15, 9, 54, 39, 14, 20, 67, 79,44, 38, 78, 23, 84, 37, 66, 5, 11, 18,41, 13,21,49, 16, 76, 1,29,53,40,42,63,25, 56, 6, 82,71,85, 89,80,34,51,60, 30, and 58 were used. In set 3, genes 39, 82, 36, 31, 52, 84, 30, 83,49, 1,44, 10, 87, 78, 77, 18, 79, 9, 73, 69, 75, 45, 14, 16, 56, 40, 58, 15, 32, 34, 42, 60, 19, 63, 47, 41,68, 13, 61,90, 89, 5, 46, 57, 8, 37, 66, 43, 21, 17, 11, 72, 74, 4, 33, 53, 12, 65, 50, 2, 81, 24, 62, 6, 23, 25, 88, 51,67, 64, 7, 80, 54, 22, and 3 were used. In set 4, genes 63, 2, 5, 52, 10, 62, 75,4, 6, 51,29, 54, 49, 55, 36, 37, 77, 46, 44, 79, 11, 59, 38, 14, 65, 43, 48, 35, 86, 78, 73, 72, 57, 8, 16, 58, 56, 82, 60, 42, 80, 13, 9, 90, 53, 66, 21, 67, 88, 89, 45, 22, 71,31, 84, 74, 15, 23, 26, 3, 68, 1, 39, 7, 50, 41,40, 81,87, 34, 18, 12, 70,47, and 25 were used. In set 5, genes 62, 82, 46, 89, 81,43, 57, 69, 9, 19, 18, 16, 80, 63, 72, 2, 54, 86, 44, 53, 31, 5, 1,61,20, 37, 58, 32, 28, 47, 34, 6, 41, 68, 15, 90, 85, 13, 23, 10, 4, 70, 76, 33, 11, 51,35, 88, 67, 84, 8, 24, 66, 65, 26, 59, 40, 79, 64, 42, 45, 22, 17, 87, 30, 12, 27, 14, 39, 56, 38, 71, 52, 36, and 60 were used. In set 6, genes 16, 85, 19, 39, 64, 76, 44, 15, 50, 73, 27, 36, 6, 62, 54, 46, 58, 68, 28, 13, 14, 21, 86, 47, 71, 87, 18, 5, 67, 1,65, 78, 12, 66, 43, 82, 38, 23, 75, 24, 49, 57, 17, 10, 29, 72, 22, 89, 90, 26, 42, 45, 2, 33, 41, 9, 8, 7, 69, 31,30, 79, 80, 84, 55, 35, 20, 70, 83, 48, 88, 60, 25, 74, and 63 were used. In set 7, genes 24, 66, 86, 48, 63, 51, 74, 37, 2, 82, 77, 22, 72, 21, 11, 90, 80, 55, 76, 68, 34, 42, 29, 62, 46, 39, 56, 31,47, 28, 16, 38, 44, 52, 1,43, 14, 20, 64, 83, 78, 58, 12, 18, 84, 67, 75, 85, 36, 25, 50, 49, 40, 33, 23, 45, 41, 73, 88, 59, 17, 32, 70, 13, 60, 57, 3, 7, 54, 4, 8, 53, 26, 15, and 69 were used. In set 8, genes 80, 38, 59, 41, 85, 44, 12, 22, 39, 17, 52, 24, 32, 62, 18, 8, 78, 74, 9, 66, 76, 14, 3, 16, 40, 28, 48, 58, 54, 29, 43, 5, 81, 77, 86, 23, 75, 82, 34, 7, 51, 64, 4, 6, 72, 61, 37, 84, 45, 33, 71, 19, 67, 88, 1, 35, 47, 83, 25, 49, 11,42, 50, 70, 2, 46, 15, 26, 27, 68, 57, 65, 13, 53, and 90 were used. In set 9, genes 4, 66, 28, 44, 20, 34, 12, 85, 6, 17, 88, 8, 39, 65, 22, 19,10, 48, 63, 23, 33, 13, 47, 81, 79, 89, 64, 53, 87, 11,46, 74, 14, 70, 37, 62, 30, 7, 71, 76, 50, 59, 77, 51, 15, 68, 55, 72, 83, 82, 78, 54, 25, 21, 27, 41, 69, 9, 58, 3, 31,75, 84, 26, 86, 49, 18, 42, 61,45, 16, 2, 24, 80, and 73 were used. In set 10, genes 78, 47, 32, 30, 46, 6, 2, 64, 11, 27, 85, 22, 79, 63, 80, 39, 90, 65, 71, 72, 21,26, 58, 15, 16, 23, 81, 1,44, 43, 40, 55, 13, 19, 25, 83, 41, 18, 53, 68, 37, 20, 49, 69, 33, 61,38, 28, 60, 45, 17, 82, 24, 4, 86, 89, 36, 51, 84, 31, 14, 88, 59, 76, 48, 5, 35, 75, 74, 7, 67, 62, 52, 56, and 54 were used.

[0167] For 80 genes, set 1, genes 29, 80, 5, 50, 63, 3, 1,55, 38, 48, 58, 30, 86, 82, 83, 6, 23, 2, 41,60, 54, 69, 15, 34, 64, 10, 27, 70, 28, 44, 8, 68, 56, 14, 36, 17, 73, 13, 88, 42, 72, 59, 67, 71, 26, 53, 37, 24, 79, 62, 52, 74, 4, 40, 47, 19, 78, 11,76, 31, 90, 12, 87, 89, 75, 66, 81, 16, 49, 65, 57, 84, 46, 20, and 21 were used. In set 2, genes 15, 21,70, 5, 79, 85, 84, 53, 69, 33, 28, 14, 75, 76, 58, 48, 13,45, 51,88, 25, 74, 39, 71, 64, 9, 60,44, 78, 7, 8, 3, 32, 89, 73, 1,4, 29, 41, 17, 46, 57, 72, 20, 86,47,49, 87, 55, 19, 37, 27, 80, 62, 54, 18, 52, 67, 63, 77, 65, 24, 31, 26, 83, 2, 22, 90, 50, 12, 16, 35, 11, 10, and 56 were used. In set 3, genes 41,4, 59, 73, 29, 22, 60, 45, 70, 10, 64, 21, 81, 36, 52, 67, 54, 38, 65, 90, 27, 87, 28, 7, 74, 43, 56, 75, 9, 35, 42, 20, 72, 47, 14, 63, 18, 68, 23, 69, 8, 50, 89, 3, 11, 82, 39, 80, 46, 16, 53, 58, 25, 79, 49, 76, 37, 30, 78, 83, 2, 84, 57, 88, 6, 32, 12, 71, 15, 55, 48, 34, 62, 61, and 13 were used. In set 4, genes 23, 31, 53, 90, 3, 40, 34, 6, 1, 83, 9, 60, 56, 50, 44, 85, 51,35, 43, 80, 65,46, 38, 88, 17, 54, 87, 10,45,42, 75, 68, 63, 58, 36, 64, 67, 77, 21,47, 30, 59, 14, 49, 70, 66, 72, 74, 27, 61, 19, 81,20, 25, 33, 57, 62, 76, 55, 78, 84, 16, 69, 37, 79, 29, 39, 32, 15, 5, 2, 12, 71, 11, and 73 were used. In set 5, genes 29, 71,21,60, 43, 78, 55, 61, 51, 90, 10, 37, 35, 53, 28, 62, 15, 1, 31, 67, 48, 36, 75, 27, 63, 87, 24, 32, 54, 79, 16, 70, 64, 40, 47, 41, 17, 38, 3, 45, 81,68, 72, 56, 77, 8, 13, 34, 57, 26, 73, 14, 6, 82, 4, 58, 89, 30, 7, 74, 69, 88, 20, 5, 46, 2,11,49, 50, 23, 33, 42, 83, 52, and 86 were used. In set 6, genes 39, 54, 30, 24, 80, 10, 21, 7, 14, 69, 38, 83, 52, 65, 46, 42, 66, 36, 61, 16, 50, 33, 2, 73, 13, 81, 48, 8, 6, 41, 12, 25, 43, 79, 35, 26, 89, 75, 60, 67, 82, 45, 20, 90, 68, 77, 58, 34, 18, 47, 22, 84, 4, 57, 32, 5, 19, 59, 86, 74, 1, 31,62, 85, 29, 53, 88, 28, 40, 37, 63, 15, 64, 49, and 55 were used. In set 7, genes 21, 68, 81,50, 36, 6, 80, 76, 90, 74, 12, 79, 34, 53, 1,4, 5, 41, 56, 47, 15, 63, 11, 14, 7, 78, 57, 65, 73, 20, 8, 64, 84, 30, 3, 13, 52, 49, 27, 86, 60, 72, 62, 29, 75, 40, 32, 2, 82, 33, 10, 24, 51, 17, 46, 38, 19, 37, 28, 69, 61, 85, 88, 22, 48, 89, 18, 25, 71, 58, 31, 35, 26, 55, and 44 were used. In set 8, genes 30, 64, 67, 79, 52, 71, 13, 3, 22, 8, 75, 41, 65, 21,60, 36, 49, 84, 33, 29, 57, 86, 15, 12, 85, 63, 6, 20, 66, 53, 51, 90, 87, 55, 11, 32, 31, 61, 78, 58, 42, 48, 5, 1, 17, 50, 70, 76, 25, 45, 2, 73, 28, 14, 89, 56, 39, 44, 7, 74, 16, 72, 35, 19, 47, 27, 43, 83, 68, 26, 18, 37, 69, 54, and 23 were used. In set 9, genes 79, 85, 48, 29, 23, 31, 62, 37, 5, 33, 3, 19, 53, 9, 36, 18, 58, 17, 81,46, 8, 35, 66, 87, 14, 30, 74, 77, 21,40, 75, 43, 42, 15, 39, 70, 60, 13, 10, 2, 72, 44, 45, 38, 4, 25, 84, 68, 50, 24, 7, 27, 82, 55, 80, 32, 89, 57, 6, 69, 83, 28, 56, 22, 16, 1,41,63, 26, 78, 12, 59, 64, 61, and 11 were used. In set 10, genes 45, 9, 24, 85, 68, 80, 73, 17, 56, 7, 8, 5, 69, 58, 37, 44, 21,29, 50, 15, 53, 25, 40, 88, 36, 32, 59, 75, 49, 35, 43, 67, 83, 31, 51,28, 60, 77, 30, 74, 22, 41,42, 64, 61, 23, 90, 13, 33, 11, 16, 20, 46, 66, 6, 87, 39,47, 65, 3, 82, 10, 72, 34, 18, 1, 38, 57, 79, 71, 26, 27, 19,48, and 76 were used.

[0168] For 85 genes, set 1, genes 62, 19, 38, 77, 64, 49, 14, 16, 47, 73, 28, 3, 54, 78, 70, 12, 75, 35, 15, 40, 21,60, 58, 86, 83, 33, 66, 59, 44, 45, 56, 9, 5, 81, 72, 68, 27, 37, 71, 52, 48, 36, 79, 6, 41, 74, 22, 46, 2, 20, 34, 13, 55, 53, 10, 88, 57, 61,4, 39, 24, 85, 76, 87, 65, 25, 23, 90, 32, 26, 80, 63, 89, 82, and 7 were used. In set 2, genes 72, 30, 36, 64, 47, 57, 67, 20, 58, 1,6, 61, 71,32, 42, 53, 87, 65, 25, 17, 9, 60, 83, 12, 51,8, 37, 75, 59, 89, 85, 22, 44, 19, 63, 7, 62, 13, 81,41,79, 43, 49, 4, 34, 68, 88, 74, 28, 31, 10, 39, 11, 55, 15, 5, 69, 50, 66, 18, 77, 46, 76, 33, 3, 35, 38, 14, 40, 86, 54, 23, 24, 48, and 78 were used. In set 3, genes 5, 67, 57,18,12, 42,43, 71, 50,19, 26, 51,52, 32, 74, 88,46, 2, 9, 77, 30, 58, 69, 81,35, 87, 90, 34, 22, 15, 84,44, 8, 3, 47, 60, 55, 66, 33, 20, 86, 39, 16, 37, 85, 73, 4, 13, 56, 27, 65, 76, 49, 54, 75, 31,68, 82, 23, 62, 7, 53, 78, 36, 64, 40, 45, 6, 70, 17, 79, 10, 21,48, and 89 were used. In set 4, genes 67, 47, 68, 38, 50, 82, 54, 56, 64, 49, 63, 14, 22, 7, 25, 12, 57, 85, 88, 5, 28, 23, 77, 44, 80, 89, 83, 20, 81,73, 11, 17, 76, 75, 32, 34, 55, 62, 21, 6, 30, 10, 71,39, 36, 74, 42, 60, 43, 8, 59, 58, 65, 3, 61, 72, 70, 79, 16, 13, 18, 19, 45, 4, 84, 1,87, 26, 46, 40, 37, 78, 15, 69, and 41 were used. In set 5, genes 82, 42, 35, 86, 14, 37, 39, 30,41,60, 44, 9, 12, 34, 50, 68, 5, 29, 46, 19, 11,28, 48, 3, 20, 77, 67, 57, 88, 55, 32, 78, 51, 71,47, 63, 6, 10, 45, 70, 8, 81, 18, 43, 69, 79, 21, 13, 66, 59, 33, 1, 31, 74, 36, 2, 24, 54, 23, 85, 72, 73, 80, 64, 84, 7, 38, 87, 58, 75, 22, 65, 15, 53, and 52 were used. In set 6, genes 55, 2, 11, 72, 4, 85, 43, 18, 46, 27, 80, 69, 9, 31, 39, 5, 81,22, 32, 3, 36, 17, 83, 37, 90, 38, 87, 44, 56, 66, 13, 6, 28, 77, 54, 79, 41, 78, 47, 29, 8, 21,63, 64, 73, 48, 14, 34, 82, 70, 30, 58, 84, 24, 26, 68, 1,65, 60, 42, 33, 20, 7, 75, 12, 57, 59, 16, 74, 88, 23, 49, 50, 40, and 71 were used. In set 7, genes 18, 40, 66, 35, 20, 85, 12, 19, 86, 26, 36, 89, 84, 88, 74, 15, 33, 75, 50, 16, 49, 32, 38, 31, 2, 27, 87, 68, 69, 53, 60, 79, 7, 21,63, 17, 90, 30, 29, 11, 56, 25, 58, 62, 48, 8, 45, 9, 72, 64, 28, 76, 3, 78, 46, 1,10, 34, 43, 83, 5, 52, 14,65, 51,41,22, 44, 61,24, 70, 54, 59, 77, and 13 were used. In set 8, genes 35, 40, 80, 57, 23, 28, 9, 83, 13, 47, 82, 36, 86, 44, 90, 55, 30, 22, 12, 42, 38, 49, 45, 8, 87, 17, 52, 3, 33, 15, 32, 21, 76, 58, 7, 53, 20, 67, 19, 29, 85, 68, 71, 39, 24, 25, 84,4, 6, 75, 63, 73, 5, 18, 31,48, 65,41,60, 37,88, 72, 1,46, 79, 16, 78, 10, 77, 34,66, 56, 61, 70, and 2 were used. In set 9, genes 51,59, 73, 9, 79, 21, 39, 67, 71,68, 28, 65, 85, 30,41,61,29, 8, 16, 78, 34, 1, 77, 90, 45, 33, 60, 89, 49, 56, 43, 62, 83, 6, 11, 18, 50, 66, 47, 19, 4, 22, 13, 27, 86, 26, 20, 17, 52, 10, 70, 54, 42, 53, 24, 76, 81, 75, 38, 64, 74, 36, 48, 32, 82, 44, 37, 57, 72, 35, 7, 14, 15, 3, and 23 were used. In set 10, genes 18, 85, 61, 1, 52, 87, 42, 13, 88, 66, 46, 57, 50, 36, 75, 39, 14, 27, 54, 20, 53, 10, 4, 30, 37, 43, 79, 80, 40, 84, 76, 45, 60, 74, 12, 31, 15, 44, 48, 3, 56, 11, 68, 19, 86, 72, 6, 9, 21, 70, 34, 83, 89, 5, 69, 64, 22, 24, 63, 65, 55, 8, 41, 28, 2, 16, 35, 77, 26, 47, 90, 49, 59, 23, and 17 were used.

Example 5: PCR based detection [0169] As noted above, the determination or measurement of gene expression may be performed by PCR, such as the use of quantitative PCR. Detecting expression of 50 or more expressed sequences in the human genome may be used in such embodiments of the invention. Additionally, expression levels of 50 or more gene sequences in the set of 74, the set of 90, or a combination set of the two (with a total of 126 gene sequences given the presence of 38 gene sequences in common between the two sets) may also be used. The invention contemplates the use of quantitative PCR to measure expression levels, as described above, of 87 gene sequences (or 50 or more sequences thereof), all of which are present in either the set of 74 or the set of 90. Of the 87 gene sequences, 60 are present in the set of 74, and 63 are present in the set of 90. The identifiers/accession numbers of the 87 gene sequences are AA456140, AA745593, AA765597, AA782845, AA865917, AA946776, AA993639, AB038160, AF104032, AF133587, AF301598, AF332224, AI041545, AI147926, AI309080, AI341378, AI457360, AI620495, AI632869, AI683181, AI685931, AI802118, AI804745, AI952953, AI985118, AJ000388, AK025181, AK027147, AK054605, AL023657, AL039118, AL110274, AL157475, AW118445, AW194680, AW291189, AW298545, AW445220, AW473119, AY033998, BC000045, BC001293, BC001504, BC001639, BC002551, BC004331, BC004453, BC005364, BC006537, BC006811, BC006819, BC008764, BC008765, BC009084, BC009237, BC010626, BC011949, BC012926, BC013117, BC015754, BC017586, BE552004, BE962007, BF224381, BF437393, BF446419, BF592799, BI493248, H05388, H07885, H09748, M95585, N64339, NM_000065, NM_001337, NM_003914, NM_004062, NM_004063, NM_004496, NM_006115, NM_019894, NM_033229, R15881, R45389, R61469, X69699, and X96757.

[0170] The use of from 50 to all of these sequences in the practice of the invention may include the use of expression levels measured for reference gene sequences as described herein. In some embodiments, the reference gene sequences are one or more of the 8 disclosed herein. The invention contemplates the use of one or more of the reference sequences identified by AF308803, AL137727, BC003043, BC006091, and BC016680 in PCR or QPCR based embodiments of the invention. Of course all 5 of these reference sequences may also be used.

SEQUENCE LISTING

[0171] <110> Arcturus Bioscience, Inc.

Erlander, Mark G.

Ma, Xiao-Jun <120> Identification of Tumors

<130> 022041-002020PC <150> US 60/577,084 <151 >2004-06-04 <160> 268 <170> Patentln version 3.1 <210> 1 <211 >2930

<212> DNA <213> Homo sapiens <400> 1 ggccactctg cagacagctc cagacaatca ggcactcgtc acacagagtc ttcctctcgt 60 ggacaggctg cgtcatccca tgaacaggca agatcaagtg caggagaaag acatggatcc 120 caccaccagc agtcagcaga cagctccaga cacgcaggca ttgggcacgg acaagcttca 180 tctgcagtca gagacagtgg acaccgaggg tacagaggta gtcaggccac tgacagtgag 240 ggacattoag aagactcaga cacacagtca gtgtcagcac agggacaagc tgggooccat 300 cagcagagcc acoaagagtc cgcacgtggc cagtcagggg aaagctctgg acgttcaggg 360 tctttcctct accaggtgag cactcatgaa cagtctgagt ccacccatgg acagtctgtg 420 cccagcactg gaggaagaca aggatcccac catgatcagg cacaagacag ctccaggcac 480 tcagcatccc aagagggtca ggacaccatt cgtggacacc cggggccaag cagaggagga 540 agacaggggt cccaccacga gcaatcggta gataggtctg gacactcagg gtcccatcac 600 agccacacca catcccaggg aaggtctgat gcctcccgtg ggcagtcagg atccagaagt 660 gcaagcagac aaacacatga ccaggaacaa tcaggagacg gctctaggca otcagggtcg 720 cgtcatcagg aagcttcctc ttgggccgac agctotagac actcacaggc agtccaggga 780 caatcagagg ggtccaggac aagoaggcgc cagggatcca gtgttagcca ggacagtgao 840 agtcagggac actcagaaga ctotgagagg cggtctgggt ctgcttccag aaaccatcgt 900 ggatctgctc aggagcagtc aagagatggc tccagacacc ccaggtccca tcacgaagac 960 agagccggtc acggggactc tgcagagagc tccagacaat caggcactca tcatgcagag 1020 aattcctctg gtggacaggc tgoatoatoc catgaacagg caagatcaag tgcaggagag 1080 agacatggat cccactacca gcagtcagca gacagctcca gacactcagg cattgggcac 1140 ggacaagctt catctgcagt cagagacagt ggacaccgag ggtccagtgg tagtcaggcc 1200 agtgacaatg agggacattc agaagactca gacacacagt cagtgtcagc ccaccgacag 1260 gctgggcgcc atcacgagag ccaccaagag tccacacgtg gccggtcacg aggaaggtct 1320 ggacgttcag ggtctttcct ctaccaggtg agcactcatg aacagtctga gtctgcccat 1380 ggacgggctg ggcccagtac tggaggaaga caaggatccc gccacgagca ggcacgagac 1440 agctccaggc actcagcgtc ccaagagggt caggacacca ttcgtggaca cccggggtca 1500 aggagaggag gaagacaggg atcctaccac gagcaatcgg tagataggtc tggacactca 1560 gggtcccatc acagccacac cacatcccag ggaaggtctg atgcctccca tgggcagtca 1620 ggatccagaa gtgcaagcag agaaacacgt aatgaggaac agtcaggaga cggctccagg 1680 cactcagggt cgcgtcacca tgaagcttcc actcaggctg acagctctag acactcacag 1740 tccggccagg gtgaatcagc ggggtccagg agaagcaggc gccagggatc cagtgttagc 1800 caggacagtg acagtgaggc atacccagag gactctgaga ggcgatctga gtctgcttcc 1860 agaaaccatc atggatcttc tcgggagcag tcaagagatg gctccagaca ccccggatcc 1920 tctcaccgcg atacagccag tcatgtacag tcttcacctg tacagtcaga ctctagtacc 1980 gctaaggaac atggtcactt tagtagtctt tcacaagatt ctgcgtatca ctcaggaata 2040 cagtcacgtg gcagtcctca cagttctagt tcttatcatt atcaatctga gggcactgaa 2100 aggcaaaaag gtcaatcagg tttagtttgg agacatggca gctatggtag tgcagattat 2160 gattatggtg aatccgggtt tagacactct cagcacggaa gtgttagtta caattccaat 2220 cctgttcttt tcaaggaaag atctgatatc tgtaaagcaa gtgcgtttgg taaagatcat 2280 ccaaggtatt atgcaacgta tattaataag gacccaggtt tatgtggcca ttctagtgat 2340 atatcgaaac aactgggatt tagtcagtca cagagatact attactatga gtaagaaatt 2400 aatggcaaag gaattaatcc aagaatagaa gaatgaagca agttcacttt caatcaagaa 2460 acttcataat actttcaggg aagttatctt ttcctgtcaa tctgtttaaa atatgctata 2520 gtatttcatt agtttggtgg taacttattt ttattgtgta atgatcttta aacgctatat 2580 ttcagaaata ttaaatggaa gaaatcaata tcatggagag ctaactttag aaaactagct 2640 ggagtatttt aggagattct gggtcaagta atgttttatg tttttgaaag tttaagtttt 2700 agacactccc caaatttcta aattaatctt tttcagaaat atcgaaggag ccaaaaatat 2760 aaaacagttc tgatatccaa agtggctata teaacatcag ggctagcaca tctttctcta 2820 ttatccttct attggaattc tagtattctg tattcaaaaa atcatcttgg acataattaa 2880 tattttagta agctgcatct aaattaaaaa taaactattc atcatataat 2930 <210> 2 <211 > 1591

<212> DNA <213> Homo sapiens <400>2 tagaatcggg ggtttcagct cactgctcct tttctttttt ttotttotct cccccgccca 60 cccccccaaa aataattgat ttgotttaca atcatccaca ctgtgttttg tggatottta 120 attatatata aoaatagtag tcattttaaa tatatattot gaaatotttg caaattttaa 180 cagaagagtc gaagctctgc gagaoccaat atttgccaat aagaatggtt atgataatta 240 gcaccatgga gcctcaggtg tcaaatggtc cgacatccaa tacaagcaat ggaccctcca 300 gcaacaacag aaactgtcct tctcccatgc aaacaggggc aaccacagat gacagcaaaa 360 ccaacctcat cgtoaactat ttaccccaga atatgaccca agaagaattc aggagtctct 420 tcgggagcat tggtgaaata gaatcctgca aacttgtgag agacaaaatt acaggacaga 480 gtttagggta tggatttgtt aactatattg atocaaagga tgcagagaaa gccatcaaoa 540 ctttaaatgg actcagactc cagaccaaaa ccataaaggt ctcatatgcc cgtocgagct 600 ctgcctcaat cagggatgct aacctctatg ttagcggcct tcccaaaacc atgacccaga 660 aggaactgga gcaacttttc tcgcaatacg gccgtatcat cacctcaoga atcctggttg 720 atcaagtcac aggagtgtcc agaggggtgg gattcatccg ctttgataag aggattgagg 780 cagaagaagc catcaaaggg ctgaatggcc agaagcccag cggtgctacg gaaccgatta 840 ctgtgaagtt tgccaacaac cccagccaga agtccagcca ggccctgctc tcccagctct 900 accagtcccc taacoggcgc tacccaggtc cacttcacca ccaggctcag aggttcaggc 960 tggacaattt gottaatatg gcctatggcg taaagagact gatgtctgga ccagtccccc 1020 cttotgcttg ttcccccagg ttotocccaa ttaocattga tggaatgaca agccttgtgg 1080 gaatgaaoat ccctggtcac acaggaactg ggtggtgcat ctttgtctac aacctgtccc 1140 ccgattccga tgagagtgtc ctctggcagc tctttggccc ctttggagca gtgaacaacg 1200 taaaggtgat tcgtgacttc aacaccaaca agtgcaaggg attcggcttt gtcaccatga 1260 ccaactatga tgaggcggcc atggccatog ccagcctcaa cgggtaccgc ctgggagaca 1320 gagtgttgca agtttccttt aaaaccaaca aagcccacaa gtcctgaatt tcccattctt 1380 acttactaaa atatatatag aaatatatac gaacaaaaca cacgcgcgca cacacacaca 1440 tacacgaaag agagagaaac aaacttttca aggcttatat tcaaccatgg actttataag 1500 ccagtgttgc ctaagtatta aaacattgga ttatcctgag gtgtaccagg aaaggatttt 1560 ataatgotta gaaaaaaaaa aaaaaaaaaa a 1591 <210> 3 <211 >2872

<212> DNA <213> Homo sapiens <400>3 tccaggaatc gatagtgcat tcgtgcgcgc ggccgcccgt cgcttcgcac agggctggat 60 ggttgtattg ggcagggtgg ctccaggatg ttaggaactg tgaagatgga agggcatgaa 120 accagcgact ggaacagcta ctacgcagac acgcaggagg cctactcctc ggtcccggtc 180 agcaacatga actcaggcct gggctccatg aactccatga acacctacat gaccatgaac 240 accatgacta cgagcggcaa catgaccccg gcgtccttca acatgtccta tgccaacccg 300 gccttagggg ccggcctgag tcccggcgca gtagccggca tgccgggggg otcggogggc 360 gccatgaaca gcatgaotgc ggccggcgtg aoggccatgg gtaoggcgct gagcccgagc 420 ggcatgggcg ccatgggtgc gcagcaggcg gcctccatga tgaatggcct gggccoctac 480 gcggccgcca tgaacccgtg catgagcccc atggcgtacg cgccgtccaa cctgggccgc 540 agccgcgcgg gcggcggcgg cgacgccaag acgttcaagc gcagttaccc gcacgccaag 600 ccgccctact cgtacatctc gctcatcacc atggccatcc agcgggcgcc cagcaagatg 660 ctcacgctga gcgagatota ccagtggatc atggacctct tcccctatta ccggcagaac 720 cagoagcgct ggcagaacto catocgccac tcgctgtcct tcaatgactg cttcgtcaag 780 gtggcaogct ccccggacaa gccgggcaag ggctcctact ggacgctgca cccggactcc 840 ggcaacatgt tcgagaacgg ctgctacttg cgccgccaga agcgcttcaa gtgcgagaag 900 cagocggggg ccggcggcgg gggcgggagc ggaagcgggg gcagcggcgc caagggcggc 960 cctgagagcc gcaaggaccc ctctggcgcc tctaacccca gcgccgactc gcccctccat 1020 cggggtgtgc aogggaagac oggccagcta gagggcgcgc cggccccggg cccggccgcc 1080 agcccccaga ototggacoa cagtggggcg acggcgacag ggggcgcctc ggagttgaag 1140 actccagcct cctcaactgc gccccccata agctccgggc ccggggcgct ggcctctgtg 1200 cccgcctctc accoggcaca cggcttggoa ccccacgagt cccagctgoa cctgaaaggg 1260 gacccccact actccttoaa ccacccgttc tccatcaaca acctcatgtc ctcctcggag 1320 cagcagcata agctggactt caaggcatac gaacaggcac tgcaatactc gccttacggc 1380 tctacgttgc ccgccagcct gcctctaggc agcgcctcgg tgaccaccag gagccccatc 1440 gagccctcag ccctggagcc ggcgtactac caaggtgtgt attccagacc cgtcctaaac 1500 acttcctagc tcccgggact ggggggtttg tctggcatag ccatgctggt agcaagagag 1560 aaaaaatcaa cagcaaacaa aaccacacaa accaaaccgt caacagcata ataaaatcca 1620 acaactattt ttatttcatt tttcatgcac aacottgccc ccagtgcaaa agactgttac 1680 tttattattg tattcaaaat tcattgtgta tattactaca aagacggccc caaaccaatt 1740 tttttcctgc gaagtttaat gatccacaag tgtatatatg aaattctcct ccttccttgc 1800 ccecctctct ttcttccctc ttggccctcc agacattcta gtttgtggag ggttatttaa 1860 aaaacaaaaa ggaagatggt caagtttgta aaatatttgt ttgtgctttt cccccctcct 1920 tacctgaccc cctacgagtt tacaggcttg tggcaatact cttaaccata agaattgaaa 1980 tggtgaagaa acaagtatac actagaggct cttaaaagta ttgaaaagac aataotgctg 2040 ttatatagca agacataaac agattataaa oatcagagcc atttgcttct cagtttacat 2100 ttctgataca tgcagatagc agatgtcttt aaatgaaata catgtatatt gtgtatggac 2160 ttaattatgc acatgctcag atgtgtagac atcctccgta tatttacata acatatagag 2220 gtaatagata ggtgatatac gtgatacgtt ctcaagagtt gcttgaccga aagttacaag 2280 gaccccaaco cctttgctct ctacccacag atggccotgg gaacaatcct caggaattgo 2340 cctcaagaac tcgcttcttt gctttgagag tgccatggtc atgtcattct gaggtacata 2400 acacataaat tagtttctat gagtgtatac catttaaaga ttttttcagt aaagggaata 2460 ttacatgttg ggaggaggag ataagttata gggagctgga tttcaaacgg tggtccaaga -2520 ttcaaaaatc otattgatag tggccatttt aatcattgcc atcgtgtgct tgtttcatoc 2580 agtgttatgc actttccaca gttggtgtta gtatagccag agggtttoat tattatttct 2640 ctttgctttc tcaatgttaa tttattgcat ggtttattct tttfctttac agctgaaatt 2700 gctttaaatg atggttaaaa ttacaaatta aattgggaat ttttatcaat gtgattgtaa 2760 ttaaaaatat tttgatttaa ataacaaaaa taataecaga ttttaagoog cggaaaatgt 2820 tcttgatcat ttgcagttaa ggactttaaa taaatcaaat gttaacaaaa aa 2872 <210> 4 <211> 540

<212> DNA <213> Homo sapiens <400>4 tgtttttcta gttcattttg tgtttccaac ttttcatgta aaattttaat tatttttgaa 60 tgtgtggatg tgagactgag gtgccttttg gtactgaaat tctttttcca tgtacctgaa 120 gtgttacttt tgtgatatag gaaatccttg tatatatact ttattggtcc ctaggcttcc 180 tattttgtta ccttgctttc tctatggcat ccaccatttt gattgttcta cttttatgat 240 atgttttcat aagtggttaa gcaagtattc tcgttacttt tgctcttaaa tccctattca 300 ttacagcaat gttggtggtc aaagaaaatg ataaacaact tgaatgttca atggtcctga 360 aatacataac aacattttag tacattgtaa agtagaatcc tctgttcata atgaacaaga 420 tgaaccaatg tggattagaa agaagtcsga gatattaatt ccaaaatatc cagacattgt 480 taaagggaaa aaattgcaat aaaatatttg taaoataaaa aaaaaaaaaa aaaaaaaaaa 540 <210>5 <211 >2508

<212> DNA <213> Homo sapiens <400> 5 agctctcccc accaataaaa ggaccaggga ggatcagaga gagcagaagg atcctgagcc 60 tcgcactctg ccgcccgcac caccttccgc tgcctctcag actctgctca gcctcacacg 120 atgtcgtgcc gctcctacag gatcagctca ggatgcgggg tcaccaggaa cttcagctcc 180 tgctcagctg tggcccccaa aaotggoaac cgctgctgca tcagcgccgc cccctaccga 240 ggggtgtoct gctaccgagg gctgacgggc ttcggcagcc gcagcctctg caacctgggc 300 tcctgcgggc cccggatagc tgtaggtggc ttccgagccg gctcctgcgg acgcagcttc 360 ggctaccgot ccgggggcgt gtgoggaccc agccccccat gcatcactac cgtgtcggtc 420 aacgagagcc tcctcacgcc cctcaacctg gagatcgacc ccaacgcaca gtgcgtgaag 480 caggaggaga aggagcagat caagtccctc aacagcaggt tcgcggcctt catcgacaag 540 gtgcgcttcc tggagcagca gaaoaagctg ctggagacca agtggcagtt ctaccagaac 600 cagcgctgct gcgagagcaa cctggagcca ctgttcagtg gctacatcga gactctgcgg 660 cgggaggccg agtgcgtgga ggccgacagc gggaggotgg cctcagagct caaccatgtg 720 caggaggtgc tggagggcta caagaagaag tatgaagagg aggtggocct gagagccaca 780 gcagagaatg agtttgtcgt tctaaagaag gacgtggact gtgcctacct gcggaaatca 840 gacctggagg ccaatgtgga ggccctggtg gaggagtcta gcttcctgag gcgcctctat 900 gaagaggaga tccgcgttct ccaagcccac atctcagaca cctcggtcat agtcaagatg 960 gacaacagcc gagacctgaa catggactgc atcatcgctg agatcaaggc tcagtatgac 1020 gatgttgcca gccgcagccg ggccgaggct gagtcctggt acogtagcaa gtgtgaggag 1080 atgaaggcca cggtgatcag gcatggggag accctgcgcc gcaccaagga ggagatcaac 1140 gagctgaacc gcatgatcca gaggctgacg gccgagattg agaatgccaa gtgccagcgt 1200 gccaagctgg aggctgctgt ggctgaggca gagcagcagg gtgaggcggc cctcagcgat 1260 gcccgctgca agctggctga gctggagggc gccctgcaga aggccaagca ggacatggcc 1320 tgoctgctca aggagtacca ggaggtgatg aactccaagc tgggcctgga catcgagatc 1380 gccacctaca ggcgcctgct ggagggcgag gaacacaggc tgtgtgaagg tgtgggctct 1440 gtgaatgtot gtgtcagcag ctcccgtggt ggagtctcct gtgggggcct ctcctacagc 1500 accaoccoag ggcgccagat cacttctggc ccctcagcca taggcggcag catcacggtg 1560 gtggcccctg actcctgtgc cccctgccag cctcgttcct ccagcttcag ctgcgggagt 1620 agccggtcgg tccgctttgc ctagtagagt catggagcoa gggcttcctg ccaagcacct 1680 gcctgcctgc atcactgcac tgaatggcat gtgaatggaa aatgtgtgct tgcttccaga 1740 atcttctgga tgttcotaca gagggaaaga cotacagagg gaaagaccct cgggcogcto 1800 ccctgogcct tttcatgcta gggagatgca tcctagttgt cctcctggca gctgttttca 1860 gaggcattcc oagoccttca cttaactcct acttagctcc aaaatacctg tatccaattt 1920 gtattattco cccagctctc agggacaaga ccagtccccc agcgtggtgg tcagcacgga 1980 agctccacct tctgggtgga ggcgccatcc taaccatcca gccaggccac ccacaacccg 2040 agaatcaggg agaaagtccc tccccagcag ccccctcctc ctggctggga agaatggtcc 2100 cccagcaagc acttgcctgt tcattcccgt toatgttttg cttctctotc agactgcctt 2160 cctgcttctg ggctaacctg ttccagccag gctcctcatg tgacctcgca gttgagaagc 2220 ccattatcgt ggggcatcct tttgcctaca gcccctggtt agggcacttt ggacaggtct 2280 tgctattcag tgaacctttg tacatttcaa agaagactcc atggctgctc cagalgcccc 2340 cttgctgggt gcaggtgggg actgtccaat gcagagctgg cgggacagag agttaagcca 2400 cttcctgggt ctccttctta tgactgtcta tgggtgcatt gccttctggg ttgtctcgat 2460 ctgtgtttca ataaatgccg ctgcaatgca aaaaaaaaaa aaaaaaaa 2508 <210> 6 <211> 1354

<212> DNA <213> Homo sapiens <220> <221 > misc_feature <222> (57)..(57) <223> a or g or c or t/u <400>6 caatcagtga aaattctata ttcctttggc atttttgtga catattcaat tcagttntat 60 gttccagcag agatcattat ccctgggatc acatccaaat ttcatactaa atggaagcaa 120 atctgtgaat ttgggataag atccttcttg gttagtatta cttgcgccgg agcaatgtct 180 tattcctcgt ttagacattg tgatttcctt cgttggagct gtgagcagca gcacattggc 240 cotaatootg ocaoctttgg ttgaaattct tacattttcg aaggaacatt ataatatatg 300 gatggtcctg aaaaatattt ctatagcatt cactggagtt gttggottct tattaggtac 360 atatataact gttgaagaaa ttatttatoo taclcccaaa gttgtagctg gcactccaca 420 gagtcctttt ctaaatttga attcaacatg cttaacatct ggtttgaaat agtaaaagca 480 gaatcatgag tcttctattt ttgtcccatt tctgaaaatt atcaagataa ctagtaaaat 540 acattgctat atacataaaa atggtaacaa actctgtttt ctttggcacg atattaatat 600 tttggaagta atcataactc tttaccagta gtggtaaacc tatgaaaaat ccttgctttt 660 aagtgttagc aatagttcaa aaaattaagt tctgaaaatt gaaaaaatta aaatgtaaaa 720 aaattaaaga ataaaaatac ttctattatt cttttatctc agtaagaaat accttaacca 780 agatatctct cttttatgct actcttttgc cactcacttg agaacagaat aggatttcaa 840 caataagaga ataaaataag aacatgtata acaaaaagct ctctccagat catccctgtg 900 aatgccaaag taaactttat gtacagtgta aaaaaaaaaa aatctcagtt atgtttttat 960 tagccaaatt ctaatgattg gctcctggaa gtatagaaaa ctcccattaa cataatataa 1020 gcatcagaaa attgcaaaca ctagaattaa ttttacactc taatggtagt tgatcttcat 1080 agtcaagagg cactgttcaa gatcatgact tagtgtttca atgaaatttg aaaagggact 1140 ttaaaactta tccagtgcaa ctcccttgtt tttcgtcaga ggaaaaggag gcctagaaag 1200 gttaagtaac ttggtcgaga ccactcagcc ttgagatcaa gaaaacctaa tcttctgact 1260 cccaggccag gatgttttat ttctcacatc atgtccaaga aaaagaataa attatgttca 1320 gcttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 1354 <210>7 <211 >2460

<212> DNA <213> Homo sapiens <400>7 cggaggcggc gccgaogggg actgctgagg cgogcagagg gtcggcggcg cccgggagcc 60 tgtcgctggc gcggtccggg cgggaggctc ggcggcgggc ggcagcatgt cggtggcggg 120 gctgaagaag cagttctaca aggcgagcca gctggtcagt gagaaggtcg gaggggccga 180 ggggaccaag ctggatgatg acttcaaaga gatggagaag aaggtggatg tcaccagcaa 240 ggcggtgaca gaagtgctgg ccaggaccat cgagtacctg cagcccaacc cagcctcgcg 300 ggctaagctg accatgctoa acacggtgtc caagatccgg ggccaggtga agaaccccgg 360 ctacccgcag tcggaggggc ttctgggcga gtgcatgatc cgccacggga aggagctggg 420 cggcgagtcc aactttggtg acgcattgct ggatgccggc gagtccatga agcgcctggc 480 agaggtgaag gactccctgg acatcgaggt caagcagaac ttcattgacc ccctccagaa 540 cctgtgcgag aaagacctga aggagatcca gcaccacctg aagaaactgg agggccgccg 600 cctggacttt gactacaaga agaagcggca gggcaagatc cccgatgagg agctacgcca 660 ggcgctggag aagttcgagg agtccaagga ggtggcagaa accagcatgc aoaacctoct 720 ggagactgac atcgagcagg tgagtcagct ctoggccctg gtggatgcac agctggacta 780 ccaccggoag gccgtgcaga tcctggacga gctggcggag aagctcaagc gcaggatgcg 840 ggaagcttcc tcacgcccta agcgggagta taagccgaag ccccgggagc cctttgacct 900 tggagagoct gagcagtcca acgggggctt cccctgcacc acagccccca agatcgcagc 960 ttcatcgtct ttccgatctt ccgacaagcc catccggacc cctagccgga gcatgccgcc 1020 cctggaccag ccgagctgca aggcgctgta cgacttcgag cccgagaacg acggggagct 1080 gggcttccat gagggcgacg tcatcacgct gaccaaccag atcgatgaga actggtacga 1140 gggcatgctg gacggccagt cgggcttctt cccgctcagc tacgtggagg tgcttgtgcc 1200 cctgccgcag tgactcaccc gtgtccccgc cccgcccctc cgtccacact ggccggcacc 1260 ccctgctggg tctcctgcat tccacggagc ccctgctgcc agggoggtgt ctgagcctgc 1320 cggcgccacc tgggccccgg cccttgaggt actccctgag caggacccca cacttgggtg 1380 ggggggctta tctgggtggg tggggatgcc tgtttacact agcgctgact cccaacggtg 1440 acggctccct tccccactcc atggcgccag cctcctoccc cgctccccaa cttctcgccc 1500 agctggccga ggcggggcaa cactaaggtg ctcttagaaa cactaatgtt cctctggggc 1560 agcccccacc tccgtcctga cocgacgggg gcccggccca ctgcctaccc tcgagtcccg 1620 cagccttaac aggatgggat cgagggtccc catggggtgg ctcagagata ggaccctggt 1680 tttaaatccc tocoagcctg gtgctggtga tgggccctgg ccctactcca gggccaatgc 1740 acccccgcct cacacacgca ctccttctcc tcaaggccag ggcagagggc ctcaccgcct 1800 cccgggcctg ctgtcagctt gcagcccggg gacagaggcc agctgggatc tgcctgagga 1860 cagagaacat ggtctcctgc agggccctgc ctcccaagcc ccgccctcag aaagccaagt 1920 accttttcag ctttttaact gcccccatcc caacccaggg aggcctgtgt cactctggca 1980 oaagctgoca ccaccagcca cccacaccca ccccagcaoa cctcacacgg gaccacagcc 2040 gcgctgccga gggccaagca caaaggttcc agtgagcgca tgtcccagcc cctggtggcc 2100 aggotoccct tgctgagccg ctgccacttc accctgtggg aagtggcccc agccatctcc 2160 tctagaccaa ggcaggcagc cccgacatct gcttcctcta tcgcccaatg caaaatcgat 2220 gaaatgggga gttctctggg ccaggocaca ttcacattcc cctccccctg tggtccagtg 2280 aagcctccgg accccaggct ctgctctgcc ctgccctgca cccccctcgt cagaagtaca 2340 tgaggggcgc agagatgagc acacagcttt gggcacggtc cagggcaaac tgaaatgtac 2400 gcctgaattt tgtaaacaga agtattaaat gtctctttct acaaaaaaaa aaaaaaaaaa 2460 <210> 8 <211> 1112

<212> DNA <213> Homo sapiens <400>8 ggcacgaggg aggtgcagag ctgagaatga ggcgatttcg gaggatggag aaatagcccc 60 gagtcccgtg gaaaatgagg ccggcggact tgotgcagct ggtgctgctg ctcgacctgc 120 ccagggacot gggcggaatg gggtgttcgt ctccaccctg cgagtgcoat oaggaggagg 180 acttcagagt cacctgcaag gatattoaac goatocccag cttaccgooc agtacgcaga 240 ctctgaagct tattgagact cacctgagaa ctattccaag tcatgcattt tciaatctgc 300 ccaatatttc cagaatctac gtatctatag atgtgaotct goagoagctg gaatcaoaot 360 ccttctacaa tttgagtaaa gtgactcaca tagaaattcg gaataccagg aacttaactt 420 acatagaccc tgatgcccto aaagagctcc ooctcctaaa gttccttggc attttcaaca 480 ctggacttaa aatgttccct gacctgacca aagtttattc cactgatata ttctttatac 540 ttgaaattac agacaaccct tacatgacgt caatccctgt gaatgctttt cagggactat 600 gcaatgaaao cttgacactg aagctgtaca acaatggctt tacttcagtc oaaggatatg 660 cttteaatgg gacaaagctg gatgctgttt acctaaacaa gaataaatac ctgacagtta 720 ttgacaaaga tgcatttgga ggagtataca gtggacoaag cttgctgctg cctcttggaa 780 gaaagtcctt gtoctttgag aotoagaagg ccccaagctc cagtatgcca tcatgatgcc 840 tgctaaggca gccaccttgg tgtacatgct cacagaggct ctgttcatgg agcagctgct 900 gtttgaaaaa ttttgaaatg caagatccac aactagatgg aaggcactct agtctttgca 960 gaaaaaaatg taectgaatg tacattgcac aatgcctggc acaaagaagg aagaatataa 1020 atgatagttc gactcgtctg tggaagaact tacaatcatg gggaaagatg gaataaaaac 1080 attttttaaa cagcaaaaaa aaaaaaaaaa aa 1112 <210>9 <211 >478

<212> DNA <213> Homo sapiens <400>9 ccccagcccc actcacccac cctccttccc accagcctgc tctccgcagg cccactgtct 60 ttgggtttaa tgacgtctct tctctgtgga acttcacgat tccttcccac ggtcaactcg 120 ggacctccca gcgaccactg cagcctgcgg acgaggccgg gacttggccg agcggatcct 180 aataagggga aaatggtaaa tgcaaacgtc ccgttacaat tttaccgcca gtgtgctgtc 240 gttccccctc cccctctccg agtcctcgtg gggacacggc ggggtctgta ggaagttggg 300 ccgggttggg ggttgctaga aggcgctggt gttttgctct gagttttaag agatcccttc 3 60 cttcctcttc ggtgaatgca ggttatttaa actttgggaa atgtactttt agtctgtcat 420 atcaaggcat gagtcactgt ctttttttgt gtgaataaat ggtttctagt acaatgga 478 <210> 10 <211 > 845

<212> DNA <213> Homo sapiens <400> 10 gcggccgccc gcacgtcogc gggtcccggc cgcgccgccg ccgcgcgccc ctgcccgaga 60 gagctctggc cccgctagcg gggccaggag ocgggcctcc caccgcagcg tcccccgccg 120 cgccagtccc cgctagtggt agtatctcgt aatagcttct gtgtgtgagc taccgtggat 180 ctcottccct tctcttgggg gccgggggga aagaaaagga tttaagcaaa ggctccctcg 240 ccctgtgagg gcgagcggca aaggcccggc tgagcccccc atgcccctcc cctccccgtg 300 taaaaagcct ccttgtgcaa ttgtcttttt tttoctttga acgtgcttct ttgtaatgac 360 caaggtaccg atttctgcta agttctccca acaacatgaa actgcctatt oacgccgtaa 420 ttctttctgt ctcccttctc tctctctctc tcgctcgctc gctctcgctc tcgctctctc 480 tcgctgcgtc ctcatttccc ctcccaatcc tctctcccct ctgcaacccc ccagctcgct 540 ggctttctct ctggcttctc tcttttcctc ctooaccoac cccotttggt ttgacaattt 600 tgtcttaagt gtttctcaaa agaggttact ttagttagca tgcgcgctgt gggcaattgt 660 tacaagtgtt cttaggttta ctgtgaagag aatgtattct gtatccgtga attgctttat 720 gggggggagg gagggctaat tatatatttt gttgttcctc tatactttgt totgttgtct 780 gcgcctgaaa agggcggaag agttacaata aagtttacaa gcgagaaccc gaaaaaaaaa 840 aaaaa 845 <210> 11 <211 > 1721

<212> DNA <213> Homo sapiens <400> 11 caccagcaca gcaaacccgc cgggatcaaa gtgtaccagt cggcagcatg gctacgaaat 60 gtgggaattg tggacccggc tactccaccc ctctggaggc catgaaagga cccagggaag 120 agatcgtcta cctgccctgc atttaccgaa acaoaggcac tgaggcccca gattatctgg 180 ccactgtgga tgttgacccc aagtctcccc agtattgcca ggtcatccac cggctgccca 240 tgccoaacct gaaggaogag ctgcatcact caggatggaa cacctgcagc agctgcttcg 300 gtgatagcac caagtcgcgc accaagctgg tgctgcccag tctcatctcc tctcgcatct 360 atgtggtgga.cgtgggctct gagccccggg.ccccaaagct gcacaaggtc attgagccca 420 aggacatcca tgccaagtgc gaactggcct ttctccacac cagccactgc ctggccagcg 480 gggaagtgat gatcagctcc ctgggagacg tcaagggcaa tggcaaaggg ggttttgtgc 540 tgctggatgg ggagacgttc gaggtgaagg ggacatggga gagacctggg ggtgctgcac 600 cgttgggcta tgacttctgg taocagcctc gacacaatgt catgatoagc actgagtggg 660 cagctcccaa tgtcttacga gatggcttca accccgctga tgtggaggct ggactgtacg 720 ggagccactt atatgtatgg gactggcagc gccatgagat tgtgcagacc ctgtctctaa 780 aagatgggct tattcccttg gagatccgct tcctgcacaa cccagacgct gcccaaggct 840 ttgtgggctg cgcactcagc tccacoatcc agcgcttcta oaagaacgag ggaggtacat 900 ggtcagtgga gaaggtgatc caggtgcccc ccaagaaagt gaagggctgg ctgctgcccg 960 aaatgccagg cctgatcacc gacatcctgc tctccctgga cgaccgcttc ctctacttca 1020 gcaactggct gcatggggac ctgaggcagt atgacatctc tgacccacag agaccccgcc 1080 tcacaggaca gctcttcctc ggaggcagca ttgttaaggg aggccctgtg caagtgctgg 1140 aggacgagga actaaagtcc cagccagagc ccctagtggt caagggaaaa cgggtggctg 1200 gaggccctca gatgatccag ctcagcctgg atgggaagcg cctctacatc accacgtcgc 1260 tgtacagtgc otgggacaag cagttttacc ctgatctcat cagggaaggc tctgtgatgc 1320 tgcaggttga tgtagacaca gtaaaaggag ggctgaagtt gaaccccaao ttcctggtgg 1380 acttcgggaa ggagcccctt ggcccagccc ttgcccatga gctcogctac cctgggggog 1440 attgtagctc tgacatctgg atttgaactc oaccctcatc acccacactc cctattttgg 1500 gccctcactt ccttggggac ctggcttcat tctgctctct cttggcaccc gacccttggc 1560 agcatgtacc acacagccaa gctgagactg tggcaatgtg ttgagtcata tacatttact 1620 gaccactgtt gcttgttgct cactgtgctg cttttccatg agctcttgga ggcaccaaga 1680 aataaactcg taaccctgtc cttcaaaaaa aaaaaaaaaa a 1721 <210> 12 <211 > 1061

<212> DNA <213> Homo sapiens <400> 12 ccggagataa cttgagggct atagaggacc ggctaatact ggtcctgaat ttggcttcag 60 gcctcaccaa ccaagtggcc gtggccttgc cgtcttgccc gtcggccccc ggtgaggcct 120 ggacccctgg ggtcccggca ccaggccccg gcttcogacc ctggcagaag cccaagatct 180 ggtccctcgc ggagactgcc acaagccccg gacacccgcg ccggctcgcc tcocggcgcg 240 ggggggtctc caccgggggg caacggtcgc gcctttccgc cctgcagctc tctccgggcc 300 gccgccgccg ccgccgctca cagactggtc tcagcgccgc tgggcaagtt cccggcttgg 360 -accaacoggc cgtttccagg cccaccgccc ggcccccgcc cgcacccgct ctccctgctg 420 ggctctgccc ctccgcaoct gctgggactt cocggagccg cgggccaccc ggctgccgcc 480 gccgocttcg ctcggccagc ggagcccgaa ggcggaacag atcgctgtag tgecttggaa 540 gtggagaaaa agttactcaa gacagctttc catcccgtgc ccaggcggcc ccagaaccat 600 ctggacgccg ccctggtctt atcggctcto tcctcatcct agttctttaa aaaaaaaoaa 660 aaaaacaaaa aaaacttttt ttaatcgttg taataattgt ataaaaaaaa tcgctctgta 720 tagttacaac ttgtaagcat gtccgtgtat aaatacctaa aagcaaaact aaacaaagaa 780 agtaagaaaa agaaataaaa ccagtcctcc tcagccotoc coaagtcgot tctgtggcac 840 cccgcattcg ctgtgaggtt tgtttgtecg gttgattttg gggggtggag tttoagtgag 900 aataaacgtg tctgcotttg tgtgtgtgta tatatacaga gaaatgtaoa tatgtgtgaa 960 ccaaattgta cgagaaagta tctatttttg gotaaataaa tgagctgctg ccactttgao 1020 tataaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a 1061 <210> 13 <211>577

<212> DNA <213> Homo sapiens <400> 13 tatgagcacc ttcacatgga tccacttgag. gaaagåaggt ggaccgaatt tgtaaacggt 60 gtgcagcaat atatatcaat tcgttctgag ataatcgcca cttaegctct ctgtggtttt 120 gccaatatcg ggtccctagg aatcgtgatc ggcggactca catccatggo tccttccaga 180 aagcgtgata tcgcctcggg ggcagtgaga gctctgattg cggggaccgt ggcctgcttc 240 atgacagcct gcatcgcagg catactctcc agcactcctg tggacatcaa ctgccatcac 300 gttttagaga atgccttcaa ctccactttc cctggaaccc caaccaaggg tgatagcttg 360 ttgccaaagt ctgttgagca gccctgttgc ccagggtcct ggtgaagtca tcccaggagg 420 aaaccccagt ctgtattctt tgaagggctg ctgcacattg ttgaatccat cgaoctttag 480 ctgcaatggg atctctaata cattttgagg tcagccactt ctccagtgga actotgaagt 540 acagatgctg aattttctgc tttggaaaga aaaaaaa 577 <210> 14 <211 >456

<212> DNA <213> Homo sapiens <400> 14 actoggcatg tgatgaacac ccatagttaa gaaaccatgg agcaagaaag cttgtggaaa 60 gtctctctcc ttcctcataa gacatgcaca ctaatacaca tacacaccaa aaaattacac 120 attttaaaac tgctaagctt ggatttaact gaatcatata tcttttatca tgttatccta 180 aaagtgagaa gacataacca agacatggaa ataaatgtga aagctggagc cgaagagtca 240 aagagctaaa aaattaagtc tagaacattc tatgaggata gtataaataa aaagaaatac 300 agtctagaca tgctgcaagg aaagaagatt ctaaagtccg tttatggagg caattocata 360 tcctttcttg aacgcacatt cagcttaccc cagagagcaa gtgaggcaat ctggcaaaag 420 attaataaag atgtaaaccc ctggaaaaaa aaaaaa 456 <210> 15 <211 >3628

<212> DNA <213> Homo sapiens <400> 15 gaattcggca cgagatagtt ttcaggttaa gaaagccaga atctttgttc agccacactg 60 aotgaacaga cttttagtgg ggttacctgg ctaacagcag cagcggcaac ggcagoagca 120 gcagcagcag cagcagcagc agcagcaggg ctcctgggat aactoaggca tagttcaaca 180 ctatgggtcc tcctctgaag ctcttcaaaa accagaaata ccaggaactg aagcaggaat 240 gcatcaaaga cagcagactt ttctgtgatc caacatttct gcctgagaat gattctcttt 300 tctacttccg actgcttcct ggaaaggtgg tgtggaaacg tccocaggac atotgtgatg 360 acccccatct gattgtgggc aacattagca accaccagct gacccaaggg agactggggc 420 acaagccaat ggtttctgca ttttcctgtt tggctgttca ggagtctcat tggacaaaga 480 caattcccaa ccataaggaa caggaatggg accctcaaaa aacagaaaaa tacgctggga 540 tatttcactt tcgtttctgg cattttggag aatggaotga agtggtgatt gatgacttgt 600 tgcccaccat taacggagat ctggtcttct ctttctccac ttccatgaat gagttttgga 660 atgctctgct ggaaaaagct tatgcaaagc tgctaggctg ttatgaggcc ctggatggtt 720 tgaccatcac tgatattatt gtggacttca cgggcacatt ggotgaaact gttgacatgc 780 agaaaggaag atacactgag cttgttgagg agaagtacaa gctattcgga gaactgtaca 840 aaacatttac caaaggtggt ctgatctgct gttcoattga gtctcccaat oaggaggago 900 aagaagttga aactgattgg ggtotgctga agggcoatac ctataocatg actgatattc 960 gcaaaattcg tcttggagag agaottgtgg aagtcttcag tgotgagaag gtgtatatgg 1020 ttcgcotgag aaaccccttg ggaagacagg aatggagtgg cccctggagt gaaatttctg 1080 aagagtggca gcaactgact gcatcagatc gcaagaacct ggggcttgtt atgtotgatg 1140 atggagagtt ttggatgagc ttggaggact tttgccgcaa ctttcacaaa ctgaatgtct 1200 gccgcaatgt gaacaaccct atttttggcc gaaaggagct ggaatcggtg ttgggatgct 1260 ggactgtgga tgatgatccc ctgatgaacc gctcaggagg ctgctataac aaccgtgata 1320 ccttcctgca gaatccccag tacatcttca ctgtgcctga ggatgggcac aaggtcatta 1380 tgtcactgca gcagaaggac ctgcgcactt accgcegaat gggaagacct gacaattaca 1440 tcattggctt tgagctcttc aaggtggaga tgaaccgcaa attccgcotc caccacctct 1500 acatccagga gcgtgctggg acttccacct atattgacac ccgcacagtg tttctgagca 1560 agtacctgaa gaagggcaac tatgtgcttg tcccaaccat gttccagcat ggtcgcacca 1620 gcgagtttct cctgagaatc ttctctgaag tgcctgtcca gctcagggaa otgactctgg 1680 acatgcccaa aatgtcctgc tggaacctgg ctcgtggcta cccgaaagta gttactcaga 1740 tcactgttca cagtgctgag gacctggaga agaagtatgc caatgaaact gtaaacccat 1800 atttggtcat caaatgtgga aaggaggaag tccgttctcc tgtccagaag aatacagttc 1860 atgccatttt tgacacccag gccattttct acagaaggac cactgacatt cctattatag 1920 tacaggtctg gaacagccga aaattctgtg atcagttctt ggggcaggtt actctggatg 1980 ctgacoccag cgactgccgt gatctgaagt ctctgtacct gcgtaagaag ggtggtccaa 2040 ctgccaaagt caagcaaggc cacatcagct tcaaggttat ttccagcgat gatctcactg 2100 agctctaaat ctgcaatccc agagaatcct gacaaagcgt gccacccttt tattttccgt 2160 caggtgccag gtottagtta agattcacaa tctttagaaa gaatgagatt cacaataatt 2220 aactcttcct ctcttctgat aaattcccca tacctcccaa tccaagtagc atctgtagct 2280 acataaccta tatacctcca gcagctggac atggggagcg acagtcctat ctagacatca 2340 tacacatttg ccaagaaagg atctctgggg cttccggggg tgagattcaa gcaggacaat 2400 aacaagaggc tggacaccct acagatgtct ttgatgtttt cagttgtttg atatatctcc 2460 cctgtagggc atgttgagga aggaggaggg ctgatcaagg ccaagctggt ctagcctgac 2520 atoctagctc ctgactgaao actatagact tcccagcagc attttcaccc agcagccaga 2580 gccggcttta agtccccaac ccttacagac accactgcca ccaocaccaa ccacgaccac 2640 caccaccacc accactcaoo accatcatca cctccggaaa gtgtagtcct gocctaaccc 2700 taaccccaag toacccccca cagtaaattt taccttcatg ttgagaaagc ttcctggtgc 2760 ttaatcaaga gctggagttc aatgagtcct agacagtgag aggggcctga gcttcagctc 2820 aatggaagcc tgctgtgtgc tcacaagacg gaaaagtgga agaagctgca gtgggagaca 2880 aagcctcggt cccccaccca tccacacaca cctacactca cacacgcgca catgggcgcg 2940 caacggaact accatttcag gcagtcagtg ggcaagagga aagataagta agtaccatac 3000 acaccttaaa agatgaggag aattcatcoa gacatattao agccagtttg gggcocctga 3060 cttgcaatgt gaaacctctt cgottgctgo taggtttaca aacaagccca ttgttcctgt 3120 gcctcctaat attcatttgt tactgaagga ccccatctgg ggacttgaga otttggtccc 3180 agcccagacg cctcagactg gtctcaaagt caagcaaggc ttcacatcag ctgcaagtgt 3240 tagtttgcca gcgcatgatc tcactgagct tctacagaat ctgcaatccc agagtcaatc 3300 atgacgaaat gtacgtccca ccatcttaac ctateaactt totgcccctc cttcaaggcc 3360 cagtataaat gccacctcct ccatgaagcc ttccctaatt ccaccccaaa cccccacctt 3420 caacaatatt tcaacgcttc tgcaatgatg aaaaagaaac atagttgtag tacttagcct 3480 acctagacca gcaagcatte atttttagct cgctcatttt ttaccatgtt ttccagtctg 3540 tttaacttct gcagtgcctt cactacactg ccttacataa accaaatcac aataaagttc 3600 atattcagta caattaaaaa aaaaaaaa 3628 <210> 16 <211>1580

<212> DNA <213> Homo sapiens <400> 16 tatgcaagtg tttaacagat gcttcactat taaaatattt tccccccaag tctcaaatat 60 tgaagaatct ctaaccaggg acaccagtcc ctacgaagac cttgggcgat tttgaagtgc 120 gggcacctcg attccccgaa tctgtagtgt ggctggtatc ggtgttcccc tggtttaact 180 agcctgtttg aaggcacaga tcattcatgg ggaagtataa ccgaatccag tcctctccac 240 cgcctgggga tcttcacttt cgcagtctac gactgcctgt gactccagaa agacaaactg 300 cagattggcc aagatgggga aattgaggca gagaagccaa gacatgtgct aaaggtcatg 360 caggctatga atggagctgg aatgtgaacg caggccatat gaccccagag cccatgttct 420 tgaaccctta gaaagacagc agcaacacac ctggtgcagc agctgcttag ttggagtggc 480 tgacaaggag agaatgattt ccaggaagag cggaacacat atggaaggcc ttagcttatc 540 tttagcgcct catacacccg ttctggactt cagaaaggcc agtgagtggg attaggcctc 600 agagatagga tgtcagtccc agtgagggåt ggcctagagc attctttaat tctttccttt 660 gggtcacaoa taagaaacaa ttttccagca ctgatgagtg ttattaacaa tgagatggga 720 tagaatttag ttttecctat ggctgtgctt caaaaataga aaagctgtct tttctctgga 780 atgattgaat gaagctctgg ggaggaaaag gtggattggc agatctctta aaggaagctt 840 ctcottctag gcactattct aaggcttaat attttaactc cctatattaa cctagttcaa 900 ctaaacagtg atctgagtaa ttttattttt attaaagctc agatcaaaat gccattaaca 960 ttgattgaga aaatcaaagg aatctttgat gtgagtggtt aaattgctga attatttcag 1020 tcccatacco tcacagcatg agtacctgat ctgatagact tctttggaat tccttttttg 1080 tttgagacag agtcttgctc tgtcgcccag gctggagtgc agcggtgtga tctcaaccat 1140 tgcaacotcc acctcccagg ttcaggtgat tctcatgcct cagcctoctg agtagctggg 1200 attacagatg tgcaccacca tgcccggcta attattttgt atctttagta gagatgaagt 1260 tttgccatgt gggccaggct gttctcaaac tactggcctc aagtgatctg ccogcctcgg 1320 cctcccagac tgctgggatt acaggcgtga ggcaccgtgc ctggctggga ttccataata 1380 aatccctctg tgtctatttc ttttttcaaa tataattttc ttoatttcca aacatcatct 1440 ttaagactcc aaggattttt ccaggcacag tggctcatac ctgtaatccc attgcttgga 1500 gaggccaagg tggaagttca tttgaggcca ggagttcgag accaggtggg caacatagtg 1560 aaaccttgtc tctacaacat 1580 <210> 17 <211 > 809

<212> DNA <213> Homo sapiens <400> 17 tgtttatata actgtgttcg ttttlgttgt tccgtcccgt cgtccttgta gactctcatc 60 ctcgtgtgtt ttggaccctc caggggtgac atcgggtctt gtgttcagct ctcctggact 120 gttattcctt gtccgcgtgt tcgtgttaga cattgtccac gatctgtatc atgcctatgt 180 ctcactttgg tctcttattt cagcgtgaac actatagttc caagtttgtt cggataattc 240 tgattcttgt caccagcgtg agatttcaac agaacttgtt tggaacaaat actcacttaa 300 aacttcagca gaagaaaaat tacttagtcc ttaggccaac caatttaact gcagtgtcat 360 gtttcacagg ccttcctaca tttagaaatc gtcacacagc tgtgataaga gtagattatt 420 ttactatgaa ataattctga atagatgaaa gcataaaatg tgagaaactg aatgtattat 480 toaggaagaa tactgagtgc cttcatttaa ctaaagttga atgtaaaagt caatttgcac 540 ttotttataa tcctctggtt tagaattata aattgttaaa accttgataa ttgtcattta 600 attatatttc aggtgtcctg aacaggtoac tagactctac attgggcagc ctttaaatat 660 gattctttgt aatgctaaat agoctttttt tctcttttta ctgcaactta atatttctat 720 ttagaacaca gaaaatgaaa atatttagaa taagttgtac atttgatgac aaataaatca 780 ctattaaaat aaaaaaaaaa aaaaaaaaa 809 <210> 18 <211 > 488

<212> DNA <213> Homo sapiens <220> <221 > misc_feature <222> (95)..(95) <223> a or g or c or t/u <400> 18 aggaacccct gtgggaaagg tttaaaccta aaaoagtgcc ccctttggct cctcctccct 60 tggcggaatg ggttcotgga ccatgtgcat ttcantgggc catgggattt acatttoctt 120 gcatccccag gtggtttgat ccctgccagg gccccttcct tcctgctcat ggttttcagg 180 gggcctgatc atggaaagta agggggttgg gccttccctt ttgggggtga accctgactc 240 catcccccta ttgcccccct aaccaatcat gcaaactttt ccocccotgg ggtaattcac 300 cagttaaaaa aagctttttt taaatgtttt gttttggggg gggggcaggg cccccttttt 360 gtttttttaa ggagttggtt ttggtttttg gctgatgttt tgttttttaa catgccccca 420 gtttgtaagg ccaaaggtaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 480 aaaaaaaa 488 <210> 19 <211 > 463

<212> DNA <213> Homo sapiens <400> 19 taagctttaa aggctctgtg ttagggcata gtctagaaac atggggccca agggcaccgg 60 gaaaacttac aaagggaaga gatggaactg ggagggttca agctaccagt tccatctctc 120 catgttttag agaattgggg cactaagtca gccaggtaag gtcaggtoag aggagggccc 180 ggatgaagca tgagatgcag agggacagtg cgtgaatgga gaccttgggt agcaccaacg 240 tgtagcggca gaggtggggt ggatgtggct gatgtcaggg agagaatggg gagcatgcac 300 agggctcagt cttatacata cattgaaaat cctttagcct ttcaaagatt attaacccaa 360 atcacctttc ttgcttactc cagatgcctc agcctctgat ataattgcta agtatctgcc 420 gtgttaaaaa taaacatttg agaatcaaaa aaaaaaaaaa aaa 463 <210> 20 <211> 2148

<212> DNA <213> Homo sapiens <400> 20 gcttcagggt acagctcccc ogcagccaga agccgggcct gcagcgcctc agcaccgctc 60 cgggacaccc cacccgcttc ccaggcgtga cctgtcaaca gcaacttcgo ggtgtggtga 120 actctctgag gaaaaaccat tttgattatt actctcagac gtgogtggca acaagtgact 180 gagacctaga aatccaagcg ttggaggtcc tgaggccagc ctaagtcgct tcaaaatgga 240 acgaaggcgt ttgtggggtt ccattoagag ccgatacatc agcatgagtg tgtggacaag 300 cccacggaga cttgtggagc tggoagggca gagcctgctg aaggatgagg ccctggccat 360 tgccgccctg gagttgctgc ccagggagct cttcccgcca otcttoatgg cagcctttga 420 cgggagacac agccagaccc tgaaggcaat ggtgcaggcc tggoccttca cctgcctccc 480 tctgggagtg ctgatgaagg gacaacatct tcacctggag accttcaaag ctgtgcttga 540 tggaottgat gtgctccttg occaggaggt tcgccccagg aggtggaaac ttcaagtgct 600 ggatttacgg aagaactctc atcaggactt ctggactgta tggtctggaa acagggccag 660 tctgtactoa tttccagagc cagaagcagc tcagcccatg acaaagaagc gaaaagtaga 720 tggtttgagc acagaggcag agcagccctt cattcoagta gaggtgctcg tagacctgtt 780 cctcaaggaa ggtgcctgtg atgaattgtt ctcctacctc attgagaaag tgaagcgaaa 840 gaaaaatgta ctacgcctgt gctgtaagaa gctgaagatt tttgcaatgc ccatgcagga 900 tatcaagatg atcctgaaaa tggtgcagct ggactctatt gaagatttgg aagtgacttg 960 tacctggaag ctacccacct tggcgaaatt ttctcottao ctgggocaga tgattaatct 1020 gcgtagactc ctcctctccc acatccatgc atcttcctac atttccccgg agaaggaaga 1080 gcagtatatc goccagttca cctctcagtt cctcagtctg cagtgcctgc aggotctcta 1140 tgtggactct ttatttttoo ttagaggccg cctggatcag ttgctcaggc acgtgatgaa 1200 ccccttggaa accctctcaa taactaactg ccggctttcg gaaggggatg tgatgcatot 1260 gtoccagagt cccagcgtca gtcagctaag tgtootgagt ctaagtgggg tcatgotgao 1320 cgatgtaagt cccgagccco tccaagctct gctggagaga gcctctgcoa ccctccagga 13 80 cctggtcttt gatgagtgtg ggatcacgga tgatcagcto cttgccctcc tgccttccct 1440 gagccactgc tcccagctta caaccttaag cttctacggg aattccatct ccatatctgc 1500 cttgcagagt ctcctgcagc acctoatcgg gctgagoaat ctgaoocacg tgctgtatcc 1560 •tgtccccctg gagagttatg aggacatcca tggtaccctc cacctggaga ggottgccta 1620 tctgcatgcc aggctcaggg agttgctgtg tgagttgggg cggcccagca tggtctggct 1680 tagtgccaac ccctgtcctc actgtgggga cagaaccttc tatgaoocgg agoccatcct 1740 gtgcccctgt ttcatgccta actagctggg tgcacatatc aaatgcttca ttctgcatac 1800 ttggacacta aagccaggat gtgcatgcat cttgaagcaa caaagcagcc acagtttcag 1860 acaaatgttc agtgtgagtg aggaaaacat gttoagtgag gaaaaaacat tcagacaaat 1920 gttcagtgag gaaaaaaagg ggaagttggg gataggcaga tgttgacttg aggagttaat 1980 gtgatotttg gggagataca tcttatagag ttagaaatag aatctgaatt tctaaaggga 2040 gattctggct tgggaagtac atgtaggagt taatccctgt gtagactgtt gtaaagaaac 2100 tgttgaaaat aaagagaagc aatgtgaagc aaaaaaaaaa aaaaaaaa 2148 <210>21 <211> 707

<212> DNA <213> Homo sapiens <220> <221 > misc_feature <222> (17)..(17) <223> a or g or c or t/u <220> <221 > misc_feature <222> (83)..(83) <223> a or g or c or t/u <400> 21 aacacagccc taccaancaa tgatgaccag tggaaaacaa tgaagtcacc aaaccctgga 60 cagggctcat gctccaggac aanttgctgt ggcgtaaatg gtccatcaga ctggcaaaaa 120 tacacatctg ccttccggac tgagaataat gatgctgact atccctggcc tcgtcaatgc 180 tgtgttatga acaatcttaa agaacctctc aacctggagg cttgtaaact aggcgtgcct 240 ggtttttatc acaatcaggg ctgctatgaa ctgatctctg gtccaatgaa ccgacacgcc 300 tggggggttg cctggtttgg atttgccatt ctctgctgga ctttttgggt tctcctgggt 3 60 accatgttct actggagcag aattgaatat taagcataaa gtgttgccac catacctcct 420 tccccgagtg actctggatt tggtgctgga accagctctc tcctaatatt ccacgtttgt 480 gccccacact aacgtgtgtg tcttacattg ccaagtcaga tggtacggac ttcctttagg 540 atctcaggct tctgcagttc tcatgactcc tacttttcat cctagtctag cattctgcaa 600 catttatata gactgttgaa aggagaattt gaaaaatgca taataactac ttccatccct 660 gcttattttt aatttgggaa aataaataca ttcgaaggaa aaaaaaa 707 <210> 22 <211 >2832

<212> DNA <213> Homo sapiens <400> 22 ggcacgaggg cgaaattgag gtttcttggt attgcgcgtt tctcttcctt gctgactctc 60 cgaatggcca tggactcgtc gcttcaggcc cgcctgtttc ccggtctcgc tatcaagatc 120 caacgcagta atggtttaat tcacagtgcc aatgtaagga ctgtgaactt ggagaaatcc 180 tgtgtttcag tggaatgggc agaaggaggt gccacaaagg gcaaagagat tgattttgat 240 gatgtggctg caataaaccc agaactctta cagcttcttc ccttacatcc gaaggacaat 300 ctgcccttgc aggaaaatgt aacaatccag aaacaaaaac ggagatccgt caactccaaa 360 attcctgctc caaaagaaag tcttcgaagc cgctccactc gcatgtccac tgtctcagag 420 cttcgcatca cggctcagga gaatgacatg gaggtggagc tgcctgcagc tgcaaactcc 480 cgcaagcagt tttcagttcc tcctgccccc actaggcctt cctgccctgc agtggctgaa 540 ataccattga ggatggtcag cgaggagatg gaagagcaag tccattccat ccgaggcagc 600 tcttctgcaa accctgtgaa ctcagttcgg aggaaatcat gtcttgtgaa ggaagtggaa 660 aaaatgaaga acaagcgaga agagaagaag gcccagaact ctgaaatgag aatgaagaga 720 gctcaggagt atgacagtag ttttccaaac tgggaatttg cccgaatgat taaagaattt 780 cgggctactt tggaatgtca tccacttact atgactgatc ctatcgaaga gcacagaata 840 tgtgtctgtg ttaggaaacg cccactgaat aagcaagaat tggccaagaa agaaattgat 900 gtgatttcca ttcctagcaa gtgtctcctc ttggtacatg aacccaagtt gaaagtggac 960 ttaacaaagt atctggagaa ccaagcattc tgctttgact ttgcatttga tgaaacagct 1020 tcgaatgaag ttgtctacag gttcacagca aggccactgg tacagacaat ctttgaaggt 1080 ggaaaagcaa cttgttttgc atatggccag acaggaagtg gcaagacaca tactatgggc 1140 ggagacctct ctgggaaagc ccagaatgca tccaaaggga tctatgccat ggcctcccgg 1200 gacgtcttcc tcctgaagaa tcaaccctgc taccggaagt tgggcctgga agtctatgtg 1260 acattcttcg agatctacaa tgggaagctg tttgacctgc tcaacaagaa ggccaagctg 1320 cgcgtgctgg aggacggcaa gcaacaggtg caagtggtgg ggctgcagga gcatctggtt 13S0 aactctgctg atgatgtcat caagatgatc gacatgggca gcgcctgcag aacctctggg 1440 cagacatttg ccaactccaa ttcctcccgc tcccacgcgt gcttccaaat tattcttcga 1500 gctaaaggga gaatgcatgg caagttctct ttggtagatc tggcagggaa tgagcgaggc 1560 gcggacactt ccagtgctga ccggcagacc cgcatggagg gcgcagaaat caacaagagt 1620 ctcttagccc tgaaggagtg catcagggcc ctgggacaga acaaggctca caccccgttc 1680 cgtgagagca agctgacaca ggtgctgagg gactccttca ttggggagaa ctctaggact 1740 tgcatgattg ccacgatctc accaggcata agctcctgtg aatatacttt aaacaccctg 1800 agatatgcag acagggtcaa ggagctgagc ccccacagtg ggcccagtgg agagcagttg 1860 attcaaatgg aaacagaaga gatggaagcc tgctctaacg gggcgctgat tccaggcaat 1920 ttatccaagg aagaggagga actgtcttcc cagatgtcca gctttaacga agccatgact 1980 cagatcaggg agctggagga gaaggctatg gaagagctca aggagatcat acagcaagga 2040 ccagactggc ttgagctctc tgagatgacc gagcagccag actatgacct ggagaccttt 2100 gtgaacaaag cggaatctgc tctggcccag caagccaagc atttctcagc cctgccagat 2160 gtcatcaagg ccttgcgcct ggccatgcag ctggaagagc aggctagcag acaaataagc 2220 agcaagaaac ggccccagtg acgactgcaa ataaaaatct gtttggtttg acacccagcc 2280 tcttccctgg ccctccccag agaactttgg gtacctggtg ggtctaggca gggtctgagc 2340 tgggacaggt tctggtaaat gccaagtatg ggggcatctg ggcccagggc agctggggag 2400 ggggtcagag tgacatggga cactcctttt ctgttcctca gttgtcgccc tcacgagagg 2460 aaggagctct tagttaccct tttgtgttgc ccttctttcc atcaagggga atgttctcag 2520 catagagctt tctccgcagc atcctgcctg cgtggactgg ctgctaatgg agagctccct 2580 ggggttgtcc tggctctggg gagagagacg gagcctttag tacagctatc tgctggctct 2640 aaaccttcta cgcctttggg ccgagcactg aatgtcttgt actttaaaaa aatgtttctg 2700 agacctcttt ctactttact gtctccctag agatcctaga ggatccctac tgttttctgt 2760 tttatgtgtt tatacattgt atgtaacaat aaagagaaaa aataaaaaaa aaaaaaaaaa 2820 aaaaaaaaaaaa 2832 <210> 23 <211 > 670

<212> DNA <213> Homo sapiens <220> <221 > misc_feature <222> (14)..(14) <223> a or g or c or t/u <220> <221 > misc_feature <222> (19)..(19) <223> a or g or c or t/u <220> <221 > misc_feature <222> (37)..(37) <223> a or g or c or t/u <220> <221 > misc_feature <222> (113)..(113) <223> a or g or c or t/u <400> 23 atcggacttc ggtnaactnt ggcaaggatt ggacagncta ggtaggctaa atgtgtgctc 60 tgtccctgtt tgcttcaaca gaggagcaag cctcagctga gaaggagggc acntggaaca 120 cctagctcct cccgtgattc cccaaaccca taacattctt ccatagggct ggaaccagtg 180 ccccgtcctg acagggatga aaagtgaacc cctcaggtca ggagaggcca gagttgaggt 240 tctgccactt cctgtccctg gggagccact caagttacca gggctaccgg ctgaaataaa 300 tcttttccgg gtagggtcaa gggcagtgtg ttcoaaggca actgatgtag gccagttgcg 360 tgactccagg tttgtcctgg tactcagtgg gtccaatcac ctggcattga tcacctggca 420 ttgatcagca cccaccccac ccctgaggct tgcccagccc ccaggccctc agatccctgc 480 tcttcctgcc tttcctgccc atgtgtcacc cagcacccaa ggttcagtga cacagggtgg 540 tttggagctg gtcactgtca tagcagctgt gatttcacaa ggaagggtgc tgcaggggga 600 cctggttgat ggggagtggg aaggggaagg aataaagaga tcttcctcag gtaaaaaaaa 660 aaaaaaaaaa 670 <210> 24 <211> 964

<212> DNA <213> Homo sapiens <400> 24 acctcgtttg ctcccagtta cttcttatct ggagcagtaa tgtagtccac ttcactcatg 60 cctaccocgc gtgtctcgtc tcctgacatg tctcacagac gctcctgaag ttaggtcatt 120 acctaaccca tagttattta ccttgaaaga tgggtctccg cacttggaaa ggtttcaaga 180 cttgatactg caataaatta tggctcttca cctgggogco aactgctgat oaacgaaatg 240 cttgttgaat caggggcaaa cggagtaoag acgtctcaag actgaaacgg ccccattgcc 300 tggtctagta gcggatctca ctcagccgca gacaagtaat cactaacccg ttttattcta 360 ttcctatctg tggatgtgta aatggctggg gggccagccc tggataggtt tttatgggaa 420 ttctttacaa taaacatagc ttgtaacttg agatetacaa atccattcat cctgattggg 480 catgaaatcc atggtcaaga ggacaagtgg aaagtgagag ggaaggtttg ctagacacct 540 tcgcttgtta tcttgtcaag atagaaaaga tagtatoatt tcacccttgc cagtaaaaac 600 ctttccatcc acccattctc agcagactcc agtattggca cagtcactca ctgccattct 660 cacactataa caagaaaaga aatgaagtgc ataagtctoc tgggaaaaga accttaaccc 720 cttctcgtgc oatgactggt gatttcatga ctcataagcc cctccgtagg catcattcaa 780 gatoaatggc ccatgcatgc tgtttgcagc agtcaattga gttgaattag aattccaacc 840 atacatttta aaggtatttg tgctgtgtgt atattttgat aaaatgttgt gacttcatgg 900 caaacaggtg gatgtgtaaa aatggaataa aaaaaaaaaa agagtcaaaa aaaaaaaaaa 960 aatt 964 <210> 25 <211> 1568

<212> DNA <213> Homo sapiens <400> 25 ggcgcccaag ccgccgccgc cagatcggtg ccgattcctg ccctgccccg accgccagcg 60 cgaccatgtc ccatcactgg gggtacggca aacacaacgg acctgagcac tggcataagg 120 acttccccat tgccaaggga gagcgccagt cccctgttga catcgacact catacagcca 180 agtatgaccc ttccctgaag occctgtctg tttcctatga tcaagcaact tccctgagga 240 tcctcaacaa tggtcatgct ttcaacgtgg agtttgatga ctctcaggac aaagcagtgc 300 tcaagggagg acccctggat ggcacttaca gattgattca gtttcacttt cactggggtt 360 cacttgatgg acaaggttca gagcatactg tggataaaaa gaaatatgct gcagaacttc 420 acttggttca ctggaacacc aaatatgggg attttgggaa agctgtgcag caacctgatg 480 gactggccgt tctaggtatt tttttgaagg ttggcagcgc taaaccgggc cttcagaaag 540 ttgttgatgt gctggattcc attaaaacaa agggcaagag tgctgacttc acaaactttg 600 cagctcgtgg cctccttcct gaatccctgg attactggac ctacccaggc tcactgacca 660 cccctcctct tctggaatgt gtgacctgga ttgtgctcaa ggaaoocatc agcgtcagca 720 gcgagcaggt gttgaaattc cgtaaactta acttcaatgg ggagggtgaa cccgaagaac 780 tgatggtgga oaactggcgc coagctcagc cactgaagaa caggcaaatc aaagcttcct 840 tcaaataaga tggtcccata gtctgtatcc aaataatgaa tcttegggtg tttcccttta 900 gctaagcaca gatctacctt ggtgatttgg acoctggttg ctttgtgtct agttttctag 960 acccttcatc tcttacttga tagacttact aataaaatgt gaagactaga ccaattgtca 1020 tgcttgacac aactgctgtg gctggttggt gctttgttta tggtagtagt ttttctgtaa 1080 cacagaatat aggataagaa ataagaataa agtaccttga ctttgttcac agcatgtagg 1140 gtgatgagca ctcacaattg ttgactaaaa tgctgccttt aaaacatagg aaagtagaat 1200 ggttgagtgc aaatccatag cacaagataa attgagctag ttaaggcaaa tcaggtaaaa 1260 tagtcatgat tctatgtaat gtaaaccaga aaaaataaat gttcatgatt tcaagatgtt 1320 atattaaaga aaaactttaa aaattattat atatttatag caaagttatc ttaaatatga 1380 attctgttgt aatttaatga cttttgaatt acagagatat aaatgaagta ttatctgtaa 1440 aaattgttat aattagagtt gtgatacaga gtatatttcc attcagacaa tatatcataa 1500 cttaataaat attgtatttt agatatattc tctaataaaa ttcagaattc taaaaaaaaa 1560 aaaaaaaa 1568 <210> 26 <211> 1964

<212> DNA <213> Homo sapiens <400> 26 ggcaogaggc atggaggcgo tgctgctggg cgoggggttg ctgctgggcg cttacgtgct 60 tgtctaotac aacctggtga aggoccogco gtgoggcggo atgggcaacc tgcggggccg 120 cacggccgtg gtcacgggtg agtgoggagg cgggtgagtg cgagotggcg gggcgcgcgg 180 agaggaggcc gggcoggcgg tagcagcggc ccgccgggct cagctcagct cggctcccgc 240 ccgcggtccg caggcgccaa cagcggcatc ggaaagatga cggcgctgga gctggcgcgc 300 cggggagcgc gcgtggtgct ggcctgccgc agccaggagc gcggggaggc ggctgccttc 360 gacctccgcc aggagagtgg gaacaatgag gtcatcttca tggccttgga cttggccagt 420 ctggcctcgg tgcgggcctt tgccactgcc tttctgagct ctgagooaog gttggacato 480 ctcatccaca atgccggtat cagttcctgt ggccggaccc gtgaggogtt taacctgctg 540 cttcgggtga accatatcgg tccctttctg ctgacaoatc tgctgctgcc ttgcctgaag 600 gcatgtgccc ctagccgcgt ggtggtggta goctcagotg cccactgtog gggaogtott 660 gacttcaaac gcctggaccg cccagtggtg ggotggcggc aggagctgcg ggcatatgct 720 gacactaagc tggctaatgt actgtttgcc cgggagctcg ccaaccagct tgaggccact 780 ggcgtcacct gctatgcagc ccacccaggg cctgtgaact cggagctgtt cctgcgccat 840 gttcctggat ggctgcgccc acttttgcgc ccattggctt ggctggtgct ccgggcacca 900 agagggggtg cccagacacc cctgtattgt gctctacaag agggcatcga gcccctcagt 960 gggagatatt ttgccaactg ccatgtggaa gaggtgcctc cagctgcccg agacgaccgg 1020 gcagcccatc ggctatggga ggccagoaag aggotggcag ggcttgggoc tggggaggat 1080 gctgaacccg atgaagaccc ccagtctgag gacteagagg ccccatctte tctaagcaoo 1140 ccccaccctg aggagcccac agtttctcaa ccttacccca gccctcagag ctcaccagat 1200 ttgtctaaga tgacgcaccg aattcaggct aaagttgagc ctgagatcca gctctcctaa 1260 ccctcaggcc aggatgcttg ccatggcact toatggtcct tgaaaacctc ggatgtgtgc 1320 gaggcoatgc cctggacact gacgggtttg tgatcttgac ctccgtggtt actttctggg 1380 gccccaagct gtgccctgga catctctttt cctggttgaa ggaataatgg gtgattattt 1440 cttcctgaga gtgacagtaa ccccagatgg agagataggg gtatgctaga cactgtgctt 1500 ctcggaaatt tggatgtagt attttcaggc cccaccctta ttgattctga tcagctotgg 1560 agcagaggca gggagtttgc aatgtgatgc actgccaaca ttgagaatta gtgaactgat 1620 ccctttgcaa ccgtctagct aggtagttaa attaccccca tgttaatgaa goggaattag 1680 gctcccgagc taagggactc gcctagggtc tcacagtgag taggaggagg gcctgggatc 1740 tgaacccaag ggtctgaggc cagggccgac tgccgtaaga tgggtgctga gaagtgagtc 1800 agggcagggc agctggtatc gaggtgoccc atgggagtaa ggggaogcct tocgggcgga 1860 tgcagggctg gggtcatotg tatctgaagc ccctcggaat aaagcgogtt gaccgccaaa 1920 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa 1964 <210> 27 <211> 953

<212> DNA <213> Homo sapiens <400> 27 agcggtggag aaaaggcaga accagagtag agattgacag tgagctgagc oaatcaggct 60 gtgaatctgc agcagtgatc ccaggtcctc caattaatac taagagagtg gaccagggcc 120 cctgaggaag acagatggca gggacagcgc gccatgaccg agagatggcg atccaggcca 180 agaaaaagct caccacggcc accaacccca ttgaaagact ccgactgcag tgcctggcca 240 ggggctctgc tgggatcaaa ggacttggca gagtgtttag aattatggat gacgataata 300 atcgaaccct tgattttaaa gaatttatga aagggttaaa tgattatgct gtggtcatgg 360 aaaaagaaga ggtggaagaa cttttccgga ggtttgataa agatggaaat ggaacaatag 420 acttcaatga atttcttcto acattaagac ctccaatgtc cagagccaga aaagaggtaa 480 tcatgcaagc ttttagaaag ttagacaaga ctggagatgg tgttataaca atcgaagacc 540 ttcgtgaagt atataatgca aaacaccacc caaagtacca gaatggggaa tggagtgagg 600 aacaagtatt taggaaattt ctggataact ttgattcacc ctatgacaaa gatggattgg 660 tgacccctga ggagttcatg aactactatg caggtgtgag cgcatccatt gacactgatg 720 tgtacttcat catcatgatg agaaccgcct ggaagcttta agcacatgac ctggggacca 780 ggccctggga cagccatgtg gctccaaatg actaaatgtc agctcaaaaa ccagaatcgt 840 atttgatttc acactcatcc taatgttttt ttctgtgtca aaatattgca ttttctgggg 900 ccaaaaaaca ggcagaaata aaagacattg agtagtcaaa aaaaaaaaaa aaa 953 <210> 28 <211 > 850

<212> DNA <213> Homo sapiens <400> 28 tagagcatta aaataactat caggcagaag aatctttctt ctcgcctagg atttcagcca 60 tgcgcgcgct ctctctcttt ctctctcttt tcctctctct ccctctttct agcctggggc 120 ttgaatttgc atgtctaatt catttactca ocatatttga attggcotga acagatgtaa 180 atcgggaagg atgggaaaaa ctgcagtcat caacaatgat taatcagctg ttgcaggoag 240 tgtcttaagg agactggtag gaggaggcat ggaaaccaaa aggccgtgtg tttagaagcc 300 taattgtcac atcaagcatc attgtcccca tgcaacaacc accaccttat acatcactto 360 ctgttttaag cagctctaaa acalagactg aagatttatt tttaatatgt tgactttatt 420 tctgagcaaa gcatcggtca tgtgtgtatt ttttcatagt cccaccttgg agcatttatg 480 tagacattgt aaataaattt tgtgcaaaaa ggactggaaa aatgaactgt attattgcaa 540 tttttttttg taaaagtagc agtttggtat gagttggcat gcatacaaga tttactaagt 600 gggataagct aattataott tttgttgtgg ataaaoaaat gcttgttgat agcctttttc 660 tatcaagaaa ccaaggagct aattattaat aacaatcatt gcacactgag tcttagcgtt 720 tctgatggaa acagtttgga ttgtataata acgccaagcc cagttgtagt cgtttgagtg 780 cagtaatgaa atotgaatct aaaataaaaa caagattatt tttgtcaaaa aaaaaaaaaa 840 aaaaaaaaaa 850 <210> 29 <211 >4670

<212> DNA <213> Homo sapiens <400> 29 gcggcgcgca cactgctcgc tgggccgcgg ctcccgggtg tcccaggccc ggccggtgcg 60 cagagoatgg cgggtgcggg occgaagcgg cgcgcgctag cggcgccggc ggccgaggag 120 aaggaagagg cgcgggagaa gatgctggcc gccaagagcg cggacggctc ggcgccggca 180 ggcgagggcg agggcgtgac cctgcagcgg aacatcacgc tgctcaacgg cgtggccatc 240 atcgtgggga ccattatcgg ctcgggcatc ttcgtgacgc ccacgggcgt gctcaaggag 300 gcaggctcgc cggggctggc gctggtggtg tgggccgcgt gcggcgtctt ctccatogtg 360 ggcgcgctct gctacgcgga gctcggoacc accatctcca aatcgggcgg ogactacgcc 420 tacatgctgg aggtctacgg ctcgctgcco gccttcctca agctctggat cgagotgctc 480 atcatccggc cttcatcgca gtacatcgtg gccctggtct tcgccaocta cctgctcaag 540 ccgctcttcc ccacctgccc ggtgcccgag gaggcagcca agctcgtggc ctgcctctgc 600 gtgctgctgc tcacggccgt gaactgctac agcgtgaagg ccgccacccg ggtccaggat 660 gcctttgccg ccgccaagct cctggocctg gccctgatca tcctgctggg cttcgtccag 720 atcgggaagg gtgatgtgtc oaatotagat cccaacttct catttgaagg caccaaactg 780 gatgtgggga aoattgtgct ggcattatac agcggcctct ttgcctatgg aggatggaat 840 taottgaatt tegtcacaga ggaaatgato aacccctaca gaaacctgcc cctggccatc 900 atcatctccc tgcccatcgt gacgctggtg tacgtgctga ccaacctggc ctacttcacc 960 accctgtcca ccgagcagat gctgtcgtcc gaggccgtgg ccgtggactt cgggaactat 1020 cacctgggcg tcatgtcctg gatcatcccc gtcttcgtgg gcctgtoctg cttcggctcc 1080 gtcaatgggt ccctgttcac atcctccagg ctcttcttcg tggggtcccg ggaaggccac 1140 ctgccctcca toctctccat gatccaccca cagctcctca cccccgtgcc gtccctcgtg 1200 ttcacgtgtg tgatgacgct gctctacgcc ttctccaagg acatcttctc cgtcatcaac 1260 ttcttcagct tcttcaactg gctctgcgtg gccctggcca tcatcggcat gatctggctg 1320 cgccacagaa agcctgagct tgagcggccc atcaaggtga acctggccct gcctgtgttc 1380 ttcatcctgg cctgcctctt cctgatcgcc gtctccttct ggaagaoacc cgtggagtgt 1440 ggcatcggct tcaccatcat cctcagcggg ctgcccgtct acttcttcgg ggtctggtgg 1500 aaaaacaagc ccaagtggct cctccagggc atcttctcca cgaccgtcct gtgtcagaag 1560 ctcatgcagg tggtccccca ggagacatag ccaggaggco gagtggctgc cggaggagca 1620 tgogcagagg ccagttaaag tagatcacct cctcgaaccc actccggttc ccogcaacco 1680 acagctcagc tgcccatccc agtccctcgc cgtccctccc aggtcgggca gtggaggctg 1740 ctgtgaaaac tctggtacga atctcalccc tcaactgagg gccagggacc caggtgtgcc 1800 tgtgctoctg cccaggagca gcttttggtc tccttgggcc ctttttccct tccctccttt 1860 gtttacttat atatatattt tttttaaact taaattttgg gtcaacttga caccactaag 1920 atgatttttt aaggagctgg gggaaggcag gagccttcct ttotoctgcc ccaagggccc 1980 agaccctggg caaacagagc tactgagact tggaacctca ttgctacgac agacttgcac 2040 tgaagccgga cagctgccca gacacatggg cttgtgacat tcgtgaaaac caaccctgtg 2100 ggcttatgtc tctgccttag ggtttgcaga gtggaaactc agccgtaggg tggcactggg 2160 agggggtggg ggatctgggc aaggtgggtg attcctctca ggaggtgctt gaggccccga 2220 tggactcctg accataatcc tagccotgag acaccatcct gagccaggga acagccccag 2280 ggttgggggg tgccggcatc tcccctagct caccaggcct ggcotctggg cagtgtggcc 2340 tcttggctat ttctgtgtcc agttttggag gctgagttct ggttcatgca gaoaaagccc 2400 tgtccttcag tcttctagaa acagagacaa gaaaggcaga cacaccgcgg ocaggcaccc 2460 atgtgggcgc ccaccctggg ctccacacag cagtgtcccc tgccccagag gtcgcagcta 2520 ccctcagcot ccaatgcatt ggcctctgta ccgcccggca gccccttctg gccggtgotg 2580 ggttcccact cccggcctag gcacctcccc gctctccctg tcacgctcat gtcctgtcct 2640 ggtcctgatg cccgttgtct aggagacaga gccaagcact gctcacgtct ctgccgcctg 2700 cgtttggagg ocætgggct ctcacccagt ccocacccgc ctgcagagag ggaactaggg 2760 caccocttgt ttctgttgtt ccogtgaatt tttttcgcta tgggaggcag ccgaggcctg 2820 gccaatgcgg cccactttcc tgagctgtcg ctgcctccat ggcagcagoc aaggaccccc 2880 agaacaagaa gacccccccg caggatccct cctgagctcg gggggctctg ccttctcagg 2940 ccccgggctt cccttctcoc cagccagagg tggagccaag tggtccagcg tcactccagt 3000 gctcagotgt ggotggagga gctggcctgt ggcacagccc tgagtgtccc aagccgggag 3060 ccaacgaagc cggacacggc ttcactgacc agcggctgct caagccgcaa gctctcagca 3120 agtgcccagc ggagcctgcc gcccccacct gggcaccggg accccctcac catccagtgg 3180 gcccggagaa acctgatgaa cagtttgggg actcaggacc agatgtccgt ctctcttgct 3240 tgaggaatga agacctttat toaoccctgc cccgttgctt ccogctgoac atggacagac 3300 ttcaeagcgt ctgctcatag gacctgcatc cttcctgggg acgaattcca ctcgtccaag 3360 ggacagccca cggtctggag gccgaggacc accagcaggc aggtggactg actgtgttgg 3420 gcaagacctc ttccctctgg gcotgttctc ttggctgcaa ataaggaoag cagctggtgc 3480 cccacctgcc tggtgcattg ctgtgtgaat ocaggaggca gtggacatcg taggcagcca 3540 cggccccggg tccaggagaa gtgctccctg gaggcacgca ccactgcttc ccactggggc 3600 cggcggggcc cacgcacgac gtcagcctct taccttcccg cctcggctag gggtcctcgg 3660 gatgccgttc tgttccaacc tcctgctctg ggacgtggac atgcctcaag gatacaggga 3720 gccggcggcc tctcgacggc acgcacttgc ctgttggctg ctgcggctgt gggcgagcat 3780 gggggctgcc agogtctgtt gtggaaagta gctgctagtg aaatggctgg ggocgctggg 3840 gtccgtcttc acactgcgca ggtctcttct gggcgtctga gctggggtgg gagctcctcc 3900 gcagaaggtt ggtggggggt ccagtctgtg atccttggtg ctgtgtgccc cactccagcc 3960 tggggacccc acttcagaag gtaggggccg tgtcccgcgg tgotgactga ggcctgcttc 4020 cccctccccc tcctgctgtg ctggaattcc acagggacca gggccaccgc aggggactgt 4080 ctcagaagac ttgatttttc cgtccctttt tctccacact ccactgacaa acgtccccag 4140 cggtttccac ttgtgggctt caggtgtttt caagcacaac ccacoacaac aagcaagtgc 4200 attttcagtc gttgtgcttt tttgttttgt gctaacgtct taotaattta aagatgctgt 4260 cggcaccatg tttatttatt tccagtggtc atgctcagcc ttgctgctct gcgtggcgoa 4320 ggtgccatgc ctgctccctg tctgtgtccc agccacgcag ggccatccac tgtgacgtcg 4380 gccgaccagg ctggacaccc tctgccgagt aatgacgtgt gtggctggga ccttctttat 4440 tctgtgttaa tggctaacct gttacactgg gctgggttgg gtagggtgtt ctggcttttt 4500 tgtggggttt ttatttttaa agaaacactc aatcatccta aaaaaaaaaa aaaaaaaaaa 4560 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 4620 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 4670 <210> 30 <211 > 176

<212> DNA <213> Homo sapiens <400> 30 gggacttgga aaggggaact gggatttggg gaggggctgg aggacttccg cacgcttcca 60 cctcottcga ootccaotgo gccccacctc cctgcctgtg tgtgttattt caaaggaaaa 120 gaacaaaagg aataaatttt ctaagctctt taaaaaaaaa aaaaaaaaaa aaaaaa 176 <210>31 <211 >2255

<212> DNA <213> Homo sapiens <400> 31 gcaggctctg cctgtggcca ctagcagaga agctgctgtc cttocaccac oagcaocgga 60 ccacctgctc caagaccagc ctcctggggg gaccaggcao ccggccttca ctggcaccca 120 gggagccgtc ctcagcagcg tcaacatgtc aaggcccagc agcagagcca tttacttgca 180 coggaaggag tactcccaga acctcacctc agagcccacc otcctgcagc acagggtgga 240 gcacttgatg acatgcaagc aggggagtca gagagtccag gggcccgagg atgccttgca 300 gaagctgttc gagatggatg cacagggocg ggtgtggagc caagacttga tcctgcaggt 360 . cagggacggc tggctgcagc tgctggacat tgagaccaag gaggagctgg actcttaccg 420 cctagacagc atccaggcca tgaatgtggc gctcaacaca tgttcctaca actccatcct 480 gtccatcacc gtgcaggagc cgggcotgcc aggcaotagc actctgctct tccagtgcca 540 ggaagtgggg gcagagcgac tgaagaccag cctgcagaag gctctggagg aagagctgga 600 gcaaagcaga cctcgacttg gaggccttca gccaggccag gacagatgga gggggcctgc 660 tatggaaagg ccgctcccta tggagcaggc acgctatctg gagccgggga tccctccaga 720 acagccccac cagaggaccc tagagcacag cctcccacca tccccaaggc ccctgccacg 780 ccacaccagt gcccgagaac caagtgcctt tactctgcct cctocaaggc ggtcctcttc 840 occcgaggac ccagagaggg acgaggaagt gctgaaccat gtcctaaggg acattgagct 900 gttcatggga aagctggaga aggcccaggo aaagaccagc aggaagaaga aatttgggaa 960 aaaaaaoaag gaccagggag gtctcaccca ggcaoagtac attgactgct tccagaagat 1020 caagtacagc ttcaacctcc tgggaaggct ggccacctgg ctgaaggaga caagtgcccc 1080 tgagctcgta cacatcctct tcaagtccct gaacttcatc ctggccaggt gccctgaggo 1140 tggcctagca gcccaagtga tctcacccct cctcacccct aaagctatca acctgctaca 1200 gtoctgtcta agcccacctg agagtaacct ttggatgggg ttgggcocag cctggaccac 1260 tagccgggcc gactggacag gcgatgagcc cctgccctac caacccacat tctcggatga 1320 otggcaactt ccagagccct ccagccaagc acccttagga taccaggacc ctgtttccct 1380 tcggcgggga agtcataggt tagggagcac ctcacacttt cctcaggaga agacacacaa 1440 ccatgaccct cagcctgggg accccaactc caggccctcc agccccåaac ctgcccagcc 1500 agccctgaaa atgcaagtct tgtacgagtt tgaagctagg aacccacggg aactgactgt 1560 ggtccaggga gagaagctgg aggttctgga ccacagoaag cggtggtggc tggtgaagaa 1620 tgaggcggga cggagcggct acattccaag caacatcctg gagccoctac agccggggac 1680 ccotgggaco cagggccagt caccctctcg ggttccaatg cttcgactta gctcgaggcc 1740 tgaagaggto acagactggc tgcaggcaga gaacttctcc actgccacgg tgaggacact 1800 tgggtcoctg acggggagcc agctacttcg cataagacct ggggagctac agatgctatg 1860 tccacaggag gccccacgaa tcctgtcccg gctggaggct gtcagaagga tgctggggat 1920 aagcccttag gcaccagctt agacaootcc aagaaccagg ccccgctgat gcaagatggc 1980 agatctgata cccattagag ccccgagaat tcctcttctg gatcccagtt tgcagcaaac 2040 cccaoacccc agctcacaca gcaaaaacaa tggacaggcc cagagggtga agcaaacagt 2100 gtcccttctg gctgtgttgg agcctoccoa gtaaccacct atttatttta cctctttccc 2160 aaacctggag catttatgcc taggcttgtc aagaatctgt tcagtccctc tccttctcaa 2220 taaaagoatc ttcaagcttg aaaaaaaaaa aaaaa 2255 <210> 32 <211> 945

<212> DNA <213> Homo sapiens <220> <221 > misc_feature <222> (36)..(36) <223> a or g or c or t/u <400> 32 ccttccattg aattccacca gacacattca ggttancttc gtaatgtctt catatgagta 60 tcaatoaaoa octtccccaa ctcaattgta ctaggttgta gagcacaagg atggtctcgt 120 gctgctctgt ggcacctgtg cctacactgc tctgagcttt gaggaggctg ctctctttgc 180 tgaccccatg atcttttctg cccttctgtt aagggcattg gccacagcaa cggggcaaat 240 gccccaagct ggctgtaagt gacccatccc tttggctocc atgattagac caaggagagg 300 catggggtcc agctgagcca ttcagaacca ttccttagca ttttccactc aaaggttaga 360 gatgagattt tctottccca aggotacotc tggccatggt tccagottca tgggggoaat 420 gggattagga aaatgaggtc aacctgcaaa ggaaagcaga tgcaagagat ggagaoagaa 480 tgggggtgtc ctggggatct tggagcctga attcattggc acaaaaggca gcagcatcct 540 cactgtatct gcagtccatt tggactcaat aaaaactttg aaagtoacat gtgttatgga 600 attccttctc agtgacacat tcatctgtgc tcagttgtcc cagcaagggt cagcccctca 660 tacccctgca gcatccgctg ctatgaagca gagctgtaaa cgccctcoct gtgtatagga 720 aaagctaoat ggagcaaatc ctcotgcctg aagaagtgca tctcagoatc acttcagctg 780 tcggggcatt tgtggggaga accagaccac ctctgcggaa ggcagoagac cctcttccag 840 ccatggatgg agttgaattc tctataaacg gttcaccagc aaaccaccaa tacattccat 900 tgtttgccta gagagaaatt taaaaataaa taaatgttca cttat 945 <210> 33 <211> 736

<212> DNA <213> Homo sapiens <400> 33 tgcggccgcg gcatgaaagg cggcgaggag aggcagoact gctgctottg acttctgagc 60 agggcttaga gagcctgccc cggcttaagc cgagctgctg gtgctgaccc tgagcgccga 120 gtccgcgagc tctgagtccg gagcctccca gccgtggagc cgtgggatga ggggggcgtt 180 gggggacagg gcaaagtcga tottggttgt acagccgccc gatcctagcg cggagctgcg 240 agcctgaccg gccgcgtctg gcatggtcag agaaagaatt ttcttttccc aactocggct 300 tttggttttg tgtgtccacc ttgcgcaaot ccggagccag ccgaccccac atggattctc 360 aacaggtggc cggcacatct tctgagcctc gctctctoat ctgaaagtgg agtgtaagtc 420 caagaagatt catttagaca aagaaggtgg aaaaaaagga ctttctgggc cagoaagtcg 480 gatgaccacc ctccaagggg cagaggaggg cccattttgt gaagaagaaa tcaactaccc 540 ggaaaacgcc acaggaggac atgtttctgc agatgtagtt gccctagaaa cagaagagta 600 tgggggtgtg aatgtcttct cttttggggg caaacactat gtccttttot ttttctagat 660 acagttaatt cotggaaatt ttagcgagtt tgttcttgtg gatattttga acaataaaga 720 gtgaaaatca aaaaaa 736 <210> 34 <211 > 2104

<212> DNA <213> Homo sapiens <400> 34 cccaatcact cctggaatac acagagagag gcagcagctt gctcagcgga caaggatgct 60 gggcgtgagg gaccaaggoc tgccotgcac tcgggcctcc tccagccagt gctgaccagg 120 gacttctgac ctgctggcca gccaggacct gtgtggggag gccctcctgc tgccttgggg 180 tgacaatctc agctccaggc taoagggaga ccgggaggat caoagagcca gcatgttaca 240 ggatcctgac agtgatcaac ctctgaacag octcgatgtc aaacccotgc gcaaaccccg 300 tatccccatg gagaccttca gaaaggtggg gatccccato atcatagcac tactgagcct 360 ggcgagtatc atcattgtgg ttgtcctcat caaggtgatt ctggataaat actacttcct 420 ctgcgggcag cctctccact tcatcccgag gaagcagctg tgtgacggag agctggactg 480 tcccttgggg gaggacgagg agcactgtgt caagagcttc cccgaagggc ctgoagtggc 540 agtccgcctc tccaaggacc gatccacact gcaggtgctg gactcggcca cagggaactg 600 gttctctgcc tgtttcgaca acttcacaga agctctcgot gagacagcct gtaggcagat 660 gggctacagc agcaaaccca ctttoagagc tgtggagatt ggccoagacc aggatotgga 720 tgttgttgaa atcacagaaa acagccagga gcttcgcatg oggaaotcaa gtgggccotg 780 tctctcaggc tccctggtct ccctgcactg tcttgcctgt gggaagagcc tgaagacccc 840 cogtgtggtg ggtggggagg aggcctctgt ggattcttgg ccttggcagg tcagcatcca 900 gtacgacaaa cagcacgtct gtggagggag catcctggac ccccactggg tcctcacggc 960 agcccactgc ttcaggaaac ataccgatgt gttcaactgg aaggtgcggg oaggctcaga 1020 caaactgggc agcttcccat ccctggctgt ggccaagatc atcatcattg aattcaaccc 1080 catgtacccc aaagacaatg acatcgccct catgaagctg cagttcccac tcactttctc 1140 aggoacagtc aggcccatct gtctgccctt ctttgatgag gagctcactc cagccacccc 1200 actctggatc attggatggg gotttacgaa gcagaatgga gggaagatgt ctgacatact 1260 gctgcaggcg tcagtccagg tcattgacag oacacggtgc aatgoagaog atgcgtacca 1320 gggggaagtc accgagaaga tgatgtgtgc aggcatcccg gaagggggtg tggacacctg 1380 ccagggtgac agtggtgggc coctgatgta coaatctgac cagtggcatg tggtgggcat 1440 cgttagctgg ggctatggct gcgggggccc gagcacccca ggagtataca ccaaggtctc 1500 agcotatotc aactggatct acaatgtctg gaaggctgag ctgtaatgct gctgcccctt 1560 tgcagtgctg ggagccgctt ccttcctgcc ctgcccacct ggggatcccc caaagtcaga 1620 cacagagcaa gagtcccctt gggtacaccc ctctgcccac agcctcagca tttcttggag 1680 cagcaaaggg cctcaattcc tgtaagagac cctcgcagcc cagaggcgcc cagaggaagt 1740 cagcagccct agctcggcca cacttggtgc tcccagcatc ccagggagag acacagccca 1800 ctgaacaagg tctcaggggt attgctaagc caagaaggaa ctttcccaca ctactgaatg 1860 gaagcaggct gtcttgtaaa agcccagatc actgtgggct ggagaggaga aggaaagggt 1920 ctgcgccagc cctgtccgtc ttcacccatc cccaagccta ctagagcaag aaaccagttg 1980 taatataaaa tgcactgccc tactgttggt atgactaccg ttacctactg ttgtcattgt 2040 tattacagct atggccacta ttattaaaga gctgtgtaac atcaaaaaaa aaaaaaaaaa 2100 aaaa 2104 <210> 35 <211 >3865

<212> DNA <213> Homo sapiens <400> 35 tttttcaatt ttgaacattt tgcaaaacga ggggttcgag gcaggtgaga gcatcctgca 60 cgtcgccggg gagcccgcgg gcacttggcg cgctctcctg ggaccgtctg cactggaaac 120 ccgaaagttt ttttttaata tatattttta tgcagatgta tttataaaga tataagtaat 180 ttttttcttc ccttttctcc accgccttga gagcgagtac ttttggcaaa ggacggagga 240 aaagctcagc aacattttag ggggcggttg tttctttctt tcttatttct tttttaaggg 300 gaaaaaattt gagtgcatcg cgatggagaa aatgtcccga ccgctccccc tgaatcccac 360 ctttatcccg cctccctacg gcgtgctcag gtccctgctg gagaacccgc tgaagctccc 420 ccttcaccac gaagacgcat ttagtaaaga taaagacaaa gaaaagaagc tggatgatga 480 gagtaacagc ccgacggtcc cccagtcgge attcctgggg cctaccttat gggacaaaac 540 ccttccctat gacggagata ctttccagtt ggaatacatg gacctggagg agtttttgtc 600 agaaaatggc attcccccca gcccatctca gcatgaccac agccctcacc ctcctgggct 660 gcagccagct tcctcggctg ccccctcggt catggacctc agcagccggg cctctgcacc 720 ccttcaccct ggcatcccat ctccgaactg tatgcagagc cccatcagac caggtcagct 780 gttgccagca aaccgcaata caccaagtcc cattgatcct gacaccatcc aggtcccagt 840 gggttatgag ccagacccag cagatcttgc cctttccagc atccctggcc aggaaatgtt 900 tgaccctcgc aaacgcaagt tctctgagga agaactgaag ccacagccca tgatcaagaa 960 agctcgcaaa gtcttcatcc ctgatgacct gaaggatgac aagtactggg caaggcgcag 1020 aaagaacaac atggcagcca agcgctcccg cgacgcccgg aggctgaaag agaaccagat 1080 cgccatccgg gcctcgttcc tggagaagga gaactcggcc ctccgccagg aggtggctga 1140 cttgaggaag gagctgggca aatgcaagaa catacttgcc aagtatgagg ccaggcacgg 1200 gcccctgtag gatggcattt ttgcaggctg gctttggaat agatggacag tttgtttcct 1260 gtctgatagc accacacgca aaccaacptt tctgacatca gcactttacc agaggcataa 1320 acacaactga ctcccatttt ggtgtgcatc tgtgtgtgtg tgcgtgtata tgtgcttgtg 1380 ctcatgtgtg tggtcagcgg tatgtgcgtg tgcgtgttcc tttgctcttg ccattttaag 1440 gtagccctct catcgtcttt tagttccaac aaagaaaggt gccatgtctt tactagactg 1500 aggagccctc tcgcgggtct cccatcccct ccctccttca ctcctgcctc ctcagctttg 1560 cttcatgttc gagcttacct actcttccag gactctctgc ttggattcac taaaaagggc 1620 cctggtaaaa tagtggatct cagtttttaa gagtacaagc tcttgtttct gtttagtccg 1680 taagttacca tgctaatgag gtgcacacaa taacttagca ctactccgca gctctagtcc 1740 tttataagtt gctttcctct tactttcagt tttggtgata atcgtcttca aattaaagtg 1800 ctgtttagat ttattagatc ccatatttac ttactgctat ctactaagtt tccttttaat 1860 tctaccaacc ccagataagt aagagtacta ttaatagaac acagagtgtg tttttgcact 1920 gtctgtacct aaagcaataa tcctattgta cgctagagca tgctgcctga gtattactag 1980 tggacgtagg atattttccc tacctaagaa tttcactgtc ttttaaaaaa caaaaagtaa 2040 agtaatgcat ttgagcatgg ccagactatt ccctaggaca aggaagcaga gggaaatggg 2100 aggtctaagg atgaggggtt aatttatcag tacatgagcc aaaaactgcg tcttggatta 2160 gcctttgaca ttgatgtgtt cggttttgtt gttccccttc cctcacaccc tgcctcgccc 2220 ccacttttct agttaacttt ttccatatcc ctcttgacat tcaaaacagt tacttaagat 2280 tcagttttcc cactttttgg taatatatat atttttgtga attatacttt gttgttttta 2340 aaaagaaaat cagttgatta agttaataag ttgatgtttt ctaaggccct ttttcctagt 2400 ggtgtcattt ttgaatgcct cataaattaa tgattctgaa gcttatgttt cttattctct 2460 gtttgctttt gaacgtatgt gctottataa agtggacttc tgaaaaatga atgtaaaaga 2520 cactggtgta tctcagaagg ggatggtgtt gtcacaaact gtggttaatc caatcaattt 2580 aaatgtttac tatagaccaa aaggagagat tattaaatcg tttaatgttt atacagagta 2640 attataggaa gttctttttt gtacagtatt tttcagatat aaatactgac aatgtatttt 2700 ggaagacata tattatatat agaaaagagg agaggaaaac tattccatgt tttaaaatta 2760 tatagcaaag atatatatto accaatgttg tacagagaag aagtgcttgg gggtttttga 2820 agtctttaat attttaagcc otatoactga cacatcagca tgttttctgc tttaaattaa 2880 aattttatga cagtatcgag gcttgtgatg acgaatcctg ctctaaaata cacaaggagc 2940 tttcttgttt cttattaggc ctcagaaaga agtcagttaa cgtcaocoaa aagcacaaaa 3000 tggattttag tcaaatattt attggatgat acagtgtttt ttaggaaaag catctgocac 3060 aaaaatgttc acttcgaaat tctgagttcc tggaatggca cgttgctgcc agtgccccag 3120 acagttcttt tctaccctgc gggcccgcac gttttatgag gttgatatcg gtgctatgtg 3180 tttggtttat aatttgatag atgtttgact ttaaagatga ttgttctttt gtttcattaa 3240 gttgtaaaat gtcaagaaat tctgotgtta cgacaaagaa acattttacg ctagattaaa 3300 atatcctttc atcaatggga ttttctagtt tcctgccttc agagtatcta atcctttaat 3360 gatctggtgg tctcotcgtc aatocatcag caatgcttct ctcatagtgt catagacttg 3420 ggaaacccaa ccagtaggat atttctacaa ggtgttcatt ttgtcacaag ctgtagataa 3480 cagcaagaga tgggggtgta ttggaattgc aatacattgt tcaggtgaat aataaaatca 3540 aaaacttttg caatcttaag cagagataaa taaaagatag caatatgaga cacaggtgga 3600 cgtagagttg gcctttttac aggcaaagag gcgaattgta gaattgttag atggcaatag 3660 tcattaaaaa catagaaaaa tgatgtcttt aagtggagaa ttgtggaagg attgtaacat 3720 ggaccatcca aatttatggc cgtatcaaat ggtagctgaa aaaactatat ttgagcactg 3780 gtctctcttg gaattagatg tttatatcaa atgagcatct caaatgtttt ctgcagaaaa 3840 aaataaaaag attctaataa aaaaa 3865 <210> 36 <211> 359

<212> DNA <213> Homo sapiens <220> <221 > misc_feature <222> (17)..(17) <223> a or g or c or t/u <400> 36 ttccttccct ccctccnttc ctcaggagcc gccagtcccc aagttggctg tggttgggca 60 cctggtttgg gtcctgcaga gotgggctca ggocotgggc tctgaacctg tgaaoccttg 120 ctgtgttacg aaactttcct tcctctgagg gccttgaacc ctctcctttt cttottttgg 180 gggtgggggt taactttatt ttctottccc tgtatctgcc tctcccttcc ctcaatttcc 240 tgttttaaaa ctgaatggca cgaaattgtt ttcctcaact cggagattco tgtatggaga 300 gaatcaattt ctatatttgc aataaatttc ttatttaaag ctaaaaaaaa aaaaaaaaa 359 <210> 37 <211> 1848

<212> DNA <213> Homo sapiens <400> 37 ggcacgaggg ccatctgtgg gggctttggg ccaggggtct ccggacagca tgagcgtggg 60 cttcatcggc gctggccagc tggcttttgc cctggccaag ggcttcacag cagcaggcgt 120 cttggctgcc cacaagataa tggctagcto cccagacatg gacctggcca cagtttctgc 180 tctcaggaag atgggggtga agttgacacc ccacaaeaag gagacggtgc agcacagtga 240 tgtgctcttc ctggctgtga agccacacat catccccttc atcctggatg aaataggcgc 300 cgacattgag gacagacaca ttgtggtgtc ctgcgcggcc ggcgtcacoa tcagctccat 360 tgagaagaag ctgtcagcgt ttcggccagc ccccagggtc atccgctgca tgaccaacac 420 tccagtcgtg gtgcgggagg gggccaccgt gtatgccaoa ggcaogcacg cccaggtgga 480 ggacgggagg ctcatggagc agctgctgag cagcgtgggc ttotgcacgg aggtggaaga 540 ggacctgatt gatgccgtca cggggctcag tggcagcggc cccgcctacg cattcacagc 600 cctggatgcc ctggctgatg ggggcgtgaa gatgggactt ccaaggcgcc tggcagtccg 660 cctcggggcc caggccctcc tgggggctgc caagatgotg ctgcactcag aacagcacco 720 aggccagctc aaggacaacg tcagctctcc tggtggggcc accatccatg ccttgcatgt 780 gctggagagt gggggcttcc gctccctgct catoaacgct gtggaggcct cctgcatccg 840 cacacgggag ctgcagtcca tggctgacca ggagcaggtg tcaceagccg ccatcaagaa 900 gaccatcctg gacaaggtga agctggactc ccctgcaggg accgctctgt cgccttctgg 960 ccacacoaag ctgctccccc gcagcctggc cccagcgggc aaggattgac acgtcctgcc 1020 tgaccaccat cctgccacca ccttctcttc tcttgtcact agggggacta gggggtcccc 1080 aaagtggccc actttctgtg gctctgatca gcgcaggggc cagccaggga catagccagg 1140 gaggggccac atcacttccc actggaaatc tctgtggtct gcaagtgctt cccagcccag 1200 aacaggggtg gattccccaa cctcaacctc ctttcttcto tgotcccaaa ccatgtcagg 1260 accaccttcc tctagagctc gggagcccgg agggtcttca cccactccta ctccagtatc 1320 agctggcacg ggctccttcc tgagagcaaa ggtcaaggac cccctctgtg aaggctcagc 1380 agaggtggga tcccacgcco cctoccggcc cctccctgcc ctccattcag ggagaaacct 1440 ctccttcccg tgtgagaagg gccagagggt ccaggcatec caagtccagc gtgaagggcc 1500 acagcccctc ttggctgcca agcacgcaga tcccatggac atttggggaa agggotcctt 1560 gggctgctgg tgaacttctg tggccaccac ctcctgctcc tgacctccct gggagggtgc 1620 tatcagttot gtcctggccc tttcagtttt ataagttggt ttccagcccc cagtgtcctg 1680 acttctgtct gccacatgag gagggaggcc ctgcctgtgt gggagggtgg ttactgtggg 1740 tggaatagtg gaggccttca actgattaga caaggcccgc ccacatcttg gagggcatct 1800 gccttactga ttaaaatgto aatgtaatct aaaaaaaaaa aaaaaaaa 1848 <210> 38 <211 >3003

<212> DNA <213> Homo sapiens <400> 38 gataaatgcg gagggacggt ccagctttag ctctctgclc gccgccgccg ctgtcgccgc 60 cacctcctct gatctacgaa agtcatgtta cccaacaccg ggaggctggc aggatgtaca 120 gtttttatca caggtgcaag ocgtggcatt ggcaaagcta ttgcattgaa agcagcaaag 180 gatggagcaa atattgttat tgctgcaaag accgcccagc cacatccaaa acttctaggc 240 acaatctata ctgctgctga agaaattgaa gcagttggag gaaaggcctt gccatgtatt 300 gttgatgtga gagatgaaca gcagatcagt gctgcagtgg agaaagcoat caagaaattt 360 ggagcttata ocattgctaa gtatggtatg tctatgtatg tgcttggaat ggcagaagaa 420 tttaaaggtg aaattgcagt caatgcatta tggcctaaaa cagccataca cactgctgct 480 atggatatgc tgggaggacc tggtatcgaa agccagtgta gaaaagttga tatcattgca 540 gatgcagcat attccatttt ccaaaagooa aaaagtttta ctggcaactt tgtoattgat 600 gaaaatatct taaaagaaga aggaatagaa aattttgacg tttatgoaat taaaccaggt 660 catcctttgc aacoagattt cttcttagat gaatacccag aagcagttag caagaaagtg 720 gaatcaactg gtgctgttcc agaattcaaa gaagagaaac tgcagctgca accaaaacca 780 cgttctggag ctgtggaaga aacatttaga attgttaagg actctctoag tgatgatgtt 840 gttaaagcca ctcaagcaat ctatctgttt gaactctecg gtgaagatgg tggcacgtgg 900 tttcttgatc tgaaaagcaa gggtgggaat gtcggatatg gagagccttc tgatcaggca 960 gatgtggtga tgagtatgac tactgatgac tttgtaaaaa tgttttcagg gaaactaaaa 1020 ccaacaatgg cattcatgtc agggaaattg aagattaaag gtaacatggc cctagcaate 1080 aaattggaga agctaatgaa tcagatgaat gccagactgt gaaggaaaat ataaaaaaaa 1140 agtcgactgc tatgctcaaa aagtaaaaaa agotcaaoag ttaaaatcta atgtttgttt 1200 tctttcctgt tatattataa ggatatgoac gtttgttctg gaaaagatag aatttgtctc 1260 taaaagactt gaaattgtaa ttaaaatggc aagctaatca aacataagct tcattaagtg 1320 ggattctaag acagtctgtg tttttatatt tcaagggttt aaccctttga gccttacatc 1380 tcattcactg totttctcca agaaaagtat tttgggogga cagtcagatc aagcagtaaa 1440 attagctctt tcaaatcttc ttgtcatgta aaatgaagct agtctgtttt aaaattttta 1500 gttttggatt gtatactaat gaaaatctta atgatgtttt tgatttttat atacttattt 1560 taaagaaaat cttatatagt acattttaca aaaattataa aaaatgaatt agtactggcg 1620 aggactaaat gaaacaataa tttttcattt tgataaotag ctttccaggt ggacttagcc 1680 ataggaaaat attactaatg taatttaaca aattgctgca tgtattccat ttaaaaatat 1740 gttfaaattg tcctaaaaca aaataatttt ctccctagga gtatgcattt ggctacagtg 1800 ttttgaaaca gaaaccttag aataggtcat tggtatgggc tgaactgtgt atcccccaat 1860 tcatttgttg aggtcctaac tcccatttct tttgaatgtg actgttcgga gatgaggcct 1920 ttaaagaggt gacttaagtt caaaggaggc tgttagtcta atocaacatg gtgtcctttg 1980 gacataagag ataccagcaa tgtgtgcaca gaacaaagac caggagagga cacagtgaga 2040 aggcagttat ctgcaagcaa agagagaggc ttcagaagaa acaaaateac cagcaccttg 2100 atctttgact tctaatctcc agaatagtga gaaataaatt tctgttgtta agccgtccac 2160 tgtgggaggc cgacgcagga ggattgcttg aggccaggag ttcaaggcca gcctggacaa 2220 catagtaaga ccctatctct acccccctaa taaattaatt taaaaagccc cccaatctgt 2280 ggtattttat tatggcagcc ctagcaagct aatacagtgg tttgagaggc tgggagggtt 2340 gaggggaaga taaaotttta aaaagctctt atctttcatt tcaatcagtt aaaaatactt 2400 gctcagtgta acaattttgc ttctcagctt ccactctaat attgttgtgc cattaagcaa 2460 tttagctaat cctgacattt cttagattca taatgttagg agcatttaat ctgtatttta 2520 caagttagga agcagaggat cagagatggg aaaggactag cccaaggcca acattaacaa 2580 gccctctaac aaaaacttta caatacattt atgttgaatg gaactccaag atctcacctc 2640 tccatccagg aatggagtcc atgtaatcaa agtgaactta aaaataggac agtttcaaca 2700 agtcaggaga ttcacagcaa ctgatcaaag ggagtccagt caacgtgagc aagcgtgatt 2760 atgatgagga agccccctct gctttaatcc acacaaggaa cgtaacctga agtaacctga 2820 tgttaaccaa tctgctgtgt ctactatgct gtttccttgt tcctgctagt gctgctttac 2880 aaatgcagac cattctatca tacctggoag ggcttctgtt ttattttgta ggctggatgc 2940 tacccagttc atgaatcgct aataaaagcc aattagatct ttaaaaaaaa aaaaaaaaaa 3000 aaa 3003 <210> 39 <211> 1824

<212> DNA <213> Homo sapiens <400> 39 tattaaaagt aooccatgga tggacctcca aatgagttta gggtaattgc gcttaaaata 60 ttaggaccaa agtacattta ttttatagat ggaggagggg aggagacgag tggggaccag 120 cttgacatcc agtcttcacc tggacatatg gaaagaacaa atgtgcgatc tgctcgttcc 180 ctctgaaggt ctctgttacg tatttcctcc totcctccag agcataataa ccaatgactg 240 ctctcagaaa ggtactgtga ccaccacttg cttggctctc caacttcctc ccccatttcc 300 ctcttgactc ctgtttgcca taacaccttc tgtcccctag octtgcotca ggtccccgac 360 gaatcctgcc cttaatctgt gggggtggta ggtggcactg gtttgaagag cttactggat 420 ctccctcagt gagtcagcct ggagttgtgt ttgaaaacca caggccctga ctgtggctgt 480 aagacctccc agacaccacc tgctgctgcc tatcatcatc ttcaggtgct gggctcccct 540 gtgggcctcg tctgcccgcc otctgctgca gctgtcccat gggcgcccgc cotctctgao 600 accacaagag agoccatcta gattccagga aaaaactcat ctttatttgc cttcttccca 660 ctgaaggtaa aagcaacatt aataaccaca aoaaatactt agtgagtgct tactattatt 720 catttaattg taggccottc catccctggc catgatgaga gacatgccat agcttactcc 780 taaagagacc tgaggacaca cgtgcacaaa catattgggc atatcatcaa tggcatcaaa 840 actgattttc cctgtctacc cagaacaggc ctgagggaga gggaaaagcg gatacccacc 900 tgtgtcgctg tttgcgtgcc aagtccagga acagtccata cagccctgct gcatcccacg 960 acgctgtcac aaagcaggag ttcatccgag gccaaggtat ggagaaactg aggcccagaa 1020 attgatgtcc agaatgcttt gctcttagcc actgtactat tatggcatat tttatcttta 1080 tgtattgcat catttcatgg attcaagttt atcaatgtcc tttgacaagt ttaaaaatct 1140 gtctgctaaa atctatcaaa tacattaagg aaaagtccca cttggcacat cteccacacc 1200 agatgttaat tattcatact gcatgactga ggattttgga ggcagagaga gattcatctg 1260 caatatttgg aacaccaatg gaggtotatg tcaacacaga atttatacag cagctggtgc 1320 tagtcagagc taatgacaga atttcagttt aataaaaaga cccccaactg agcacaccat 1380 cttgaaaaaa gtatacttat caaacagctt tcaatcagtt caagagagac accttaattg 1440 gggagaggaa gaattgcaga gtagtttgta atcatgccaa ttccagatca ataactgcat 1500 gtctgttctt tggtagaaat agcttttgct ttatattaag taatcacata tatattctct 1560 ctatttggat aaggaaacct tcgctttatt tgacaatgta taatgatata ctcttctaat 1620 tcacctctgt gtcttcacaa taaacatgag taaaatttag acaagtgatg gtaaaggtca 1680 atataattat ttatttttaa aataaatttt gtatctaaca ggaaagcagt tcttatgaaa 1740 tttttatatt ttcaaaaatt gttttgttca aataaaattt tatgagtaaa gttaaaaaaa 1800 aaaaaaaaaa aaaaaaaaaa aaaa 1824 <210>40 <211 > 630

<212> DNA <213> Homo sapiens <400 40 gggtacctgg tggggccaat caccgagcca tgaacatcag taacgtactc taaagaccaa 60 ggotacgatg gctatgatgg tcagaattac taccaccacc agtgaagctc cagcctggga 120 tgaattcatc cattctggct ttgcatccgg ctaccatttt cgaagttcaa ctcaggaagg 180 tgcaatataa caaatgtgca tattataatg aggaatggta ctaccgttcc agattttctg 240 taattgcttc tgcaaagtaa taggcttctt gtcccttttt tttctggcat gttatggaat 300 gatcattgta aatcaggaoc atttatcaag cagtaoacca actcataaga tcaaatttca 360 ttgaatggtt tgaggttgta gctctataaa tagtagtttt taacatgcct gtagtattgc 420 taactgcaaa aacatactct ttgtacaaga agtgcttcta agaatttcat tgacattaat 480 gacactgtat acaataaatg tgtagtttct taatcgcact acctatgcaa cactgtgtat 540 taggtttatc atcctcatgt atttttatgt gacctgtatg tatattctaa tctacgagtt 600 ttatcacaaa taaaaatgca atcottcaaa 630 <210>41 <211> 970

<212> DNA <213> Homo sapiens <400> 41 aaggtgggct ttcattgtga tttttgttct gttgcagtaa tataggagca cattttggcc 60 attgtaatta cagggaacaa agggattgcg gacacatatc tggacttctt ttcctccctt 120 attgttgtgg aagagacact agaaatgctc aaacacctgc aatatacaga atatacacaa 180 ttttattcca gtatttccct aacatatggt ttaaaattat tccaggtata cagtgtatgc 240 aattctgcat tatcacagag gaacaacttc ttttttaaaa aataaatagg toagccattt 300 ttattaacgt gcaaaaactt tatcactcta acatgctcta ggtagttgag gaaaagaggt 360 ctgatcactg tttgtatttt attttctttg tgggaacatt tcacctgctg agtgtacatg 420 aatttgcttt ctataaaagg cttttatgag tttacagtag aatoagtgga aggaagagtt 480 aataagggct gtttttaaaa aaaoaaaoaa acaaacaaaa caaataatta aaaaaaaatt 540 ttaoattcct tcctattotc taactacact tgggaagtgo acttoagata agtttgcagt 600 gtgactgaga gatgaaggaa atccatagaa aaggtcotot tagtgaacaa aatttagtta 660 ttaactttat agctatgaaa tttccccggg catttgtttt tgttcaaaca gactttaacc 720 tctgcatcat acttaaccct gcgacatgcg tacagtatgc atattttgtt ttgaaaaaaa 780 atgtttcgtt ccagtctgtt aagaatattc aaaaataata aaggtattgc ttaataaaat 840 tgotagaatt gtttagcagt aoatgcacaa tattttacta gattctttgt tttaatagtg 900 ttttgttgag actgaaaatc ttaaaatggt ctgcgcaaat acaaaaaaaa agaaaacacc 960 aaaaaaaaaa . 970 <210> 42 <211> 1743

<212> DNA <213> Homo sapiens <400> 42 ggtgttgttc cggacacata gaaagataac gacgggaaga gcggggcccg ctttggggtc 60 caggcaggtt ttggggcctc ctgtctggtg ggaggaggcc gcagcgcagc accctgctcg 120 tcacttggga tggagaccgg ctttcocgca atcatgtacc ctggatcttt tattgggggc 180 tggggagaag agtatctcag ctgggaagga ccggggctcc cagatttcgt cttccagcag 240 cagcccgtgg agtctgaagc aatgcactgc agcaacccca agagtggagt tgtgctggct 300 acagtggccc gaggtcccga tgcttgtcag atactcacca gagcccogct gggooaggat 360 cccccgcaga ggacagtgct agggctgcta actgcaaatg ggcagtacag gaggacctgt 420 ggooagggga tcacaagaat caggtgttat tctggatcag aaaatgcctt ccctccagct 480 ggaaagaaag cactccctga ctgtggggtc caagagcccc ccaagcaagg gtttgacatc 540 tacatggatg aactagagca gggggacaga gacagctgct cggtcagaga ggggatggca 600 tttgaggatg tgtatgaagt agacaccggc acactcaagt cagacctgca cttcctgctg 660 gatttcaaca cagtttcccc tatgctggta gattcatctc tcctctccca gtctgaagat 720 atatccagtc ttggcacaga tgtgataaat gtgactgaat atgctgaaga aatttatcag 780 taccttaggg aagctgaaat aaggcacaga cccaaagcac actacatgaa gaagcagcca S40 gacatcacgg aaggcatgcg cacgattctg gtggactggc tggtggaggt tggggaagaa 900 tataaacttc gagcagagac cctgtatctg gctgtcaact tcctggacag gttcctttca 960 tgtatgtctg ttctgagagg gaaactgcag ctcgtaggaa cagcagctat gcttttggct 1020 tcgaaatatg aagagatata tcctcctgaa gtagacgagt ttgtctatat caccgatgat 1080 acatacacaa aacgacaact gttaaaaatg gaacacttgo ttctgaaagt tctagctttt 1140 gatctgacag taccaaccac caaccagttt ctccttcagt acttgaggcg acaaggagtg 1200 tgcgtcagga ctgagaacct ggctaagtac gtagcagagc tgagtctact tgaagcagat 1260 ccattcttga aatatcttcc ttcactgata gctgcagcag ctttttgcct ggcaaactat 1320 aotgtgaaca agcacttttg gccagaaacc cttgctgcat ttacagggta ttcattaagt 1380 gaaattgtgc cttgcctgag tgagcttcat aaagcgtacc ttgatatacc ocatcgacct 1440 cagcaagcaa ttagggagaa gtacaaggct tcaaagtacc tgtgtgtgtc cctcatggag 1500 ccacctgcag ttcttcttct acaataagtt tctgaatgga agcacttcca gaacttcacc 1560 tccatatcag aagtgccaat aatcgtcata ggcttctgca cgttggatca actaatgttg 1620 tttacaatat agatgacatt ttaaaaatgt aaatgaattt agtttccctt agactttagt 1680 agtttgtaat atagtocaac attttttaaa caataaactg cttgtcttat gacaaaaaaa 1740 aaa 1743

<210> 43 <211 > 697 <212> DNA <213> Homo sapiens <400> 43 tccaagccat taaggactgt ggaacttgot atgatcatgg acgtgctgta tggtggcgtt 60 tgttatgcag gaattgatac agatoctgag ctaaaatacc oaaaaggtgc tgggcgagtt 120 gctttctcca atcagcagag ctatattgct gcoattagtg ctcggtttgt tcagcttcag 180 catggtgata ttgataaacg tgtggaggta aagccatatg tgctagatga ooagatgtgt 240 gatgaatgcc agggcgcacg ctgtggtgga aaatttgctc cctttttttg tgcoaatgtc 300 acttgcctgc agtattactg tgagttttgt tgggcaaata tccactctcg tgctggacgt 360 gagttccata agccattggt aaaggaaggt gctgatcgcc cacgtcagat ccacttccgc 420 tggaactaag aatagcaaac tggcctotgt ttaacaagga aagaaagggt gcatgtggct 480 tactgtgtot gaagataotg acatgcagaa gaaataagtg cattcttctg cttttcaccc 540 cagctatcaa tacatgcatc tttatcagca gcoaaaacac tacaagcctc ttgtttttoa 600 ccaaaaccpt acatctcagg cttactaatt tttgtgatat tttcatgttc aaataaaatg 660 tttttttgta ttttcaaaaa aaaaaaaaaa aaaaaaa 697 <210> 44 <211 >2227

<212> DNA <213> Homo sapiens <400> 44 otcgatgtag aggggttggt agcagacagg tggttacatt agaatagtca cacaaactgt 60 tcagtgttgc aggaaccttt tcttgggggt gggggagttt occttttcta aaaatgcaat 120 gcactaaaac tattttaaga atgtagttaa ttctgcttat tcataaagtg ggcatcttct 180 gtgttttagg tgtaatatcg aagtcctggc ttttctcgtt ttctcacttg ctctcttgtt 240 ctctgttttt ttaaaccaat tttactttat gaatatattc atgacatttg taataaatgt 300 cttgagaaag aatttgtttc atggcttcat ggtcatcact caagctcccg taaggatatt 360 aocgtctoag gaaaggatea ggactceatg tcacagtcct gccatcttac tttcctcttg 420 tcgagttctg agtggaaata actgcattat ggctgcttta acctcagtca tcaaaagaaa 480 cttgctgttt tttaggcttg atctttttcc tttgtggtta attttcctgt atattgtgaa 540 aatgggggat tttccctctg ctccoaccca cctaaacaca gcagcoattt gtacctgttt 600 gcttcccatc ccacLtggca cccactctga cctcttgtca gtttcctgtt cctggttcca 660 totttttgaa aaaggccctc ctttgagcta caaacatctg gtaagacaag tacatccact 720 catgaatgca gacacagcag ctggtggttt tgtgtatacc tgtaaagaca agctgagagg 780 cttacttttt ggggaagtaa aagaagatgg aaatggatgt ttcatttgta tgagtttgga 840 gcagtgctga aggccaaagc cgcctaotgg tttgtagtta acctagagaa ggttgaaaaa 900 ttaatcctac ctttaaaggg atttgaggta ggctggattc oatcgccaoa ggactttagt 960 tagaattaaa ttcctgcttg taatttatat ccatgtttag gcttttcata agatgaaaoa 1020 tgccacagtg aacacaotcg tgtacatatc aagagaagaa ggaaaggcac aggtggagaa 1080 cagtaaaagg tgggcagatg tctttgaaga aatgctcaat gtctgatgct aagtgggaga 1140 aggcagagaa caaaggatgt ggcataatgg tcttaacatt atccaaagac ttgaagctcc 1200 atgtctgtaa gtcaaatgtt acacaaaaaa aaatgcaaat ggtgtttcat tggaattacc 1260 aagtgcttag aacttgotgg ctttcccata ggtggtaaag gggtctgagc tcacaccgag 1320 ttgtgcttgg cttgcttgtg cagctccagg cacccggtgg gcactctggt ggtgtttgtg 1380 gtgaactgaa ttgaatccat tgttgggctt aagttactga aattggaaca ccctttgtcc 1440 ttotcggcgg gggcttcctg gtctgtgctt tacttggctt ttttccttcc cgtcttagco 1500 tcaccccctt gtcaaccaga ttgagttgct atagcttgat gcagggaccc agtgaagttt 1560 ctccgttaaa gattgggagt cgtcgaaatg tttagattct tttaggaaag gaattatttt 1620 cccccctttt acagggtagt aacttctcca cagaagtgcc aatatggcaa aattacacaa 1680 gaaaacagta ttgoaatgao accattacataaggaacatt gaactgttag aggagtgctc 1740 ttccaaacaa aacaaaaatg tctctaggtt tagtcagagc tttoaoaagt aataacottt 1800 ctgtattaaa atcagagtaa ccctttctgt attgagtgca gtgtttttta ctcttttctc 1860 atgcacatgt tacgttggag aaaatgttta caaaaatggt tttgttacac taatgcgcac 1920 cacatattta tggtatattt taagtgactt tttatgggtt atttaggttt tcgtottagt 1980 tgtagcacac ttaccctaat tttgccaatt attaatttgc taaatagtaa tacaaatgac 2040 aactgoatta aatttaotaa ttataaaagc tgcaagcaga ctggtggcaa gtacacagcc 2100 cttttttttg cagtgctaac ttgtctactg tgtattatga aaattactgt tgtcoccoca 2160 cccttttttc cttaaataaa gtaaaaatga caccctaaaa aaaaaaaaaa aaaaaaaaaa 2220 aaaaaaa 2227 <210> 45 <211 > 267

<212> DNA <213> Homo sapiens <400> 45 tatacggctg ctagaagacg acagaaggtg gcttgggggt ggatatcttt gggttgctgg 60 aaaaggtgtg ggaaggttca ggatggtggg agggactgag gtccctgagg tgaagaggcc 120 cttggtcctg acgggtttga cccgtgcctg gacccttgga gcagtgttgt gtgaacttgc 180 ctagaactct gccttctccg ttgtcaataa agcctccccc tcatgaccta aaaaaaaaaa 240 aaaaaaaaaa aaaaaaagtc gtatcga 267 <210> 46 <211 > 4415 <212> DNA <213> Homo sapiens <400> 46 gagcaggaaa atatataccc taaaoagaaa ctcttacttg ttttatgagc aagtctgagt 60 gagtcctaaa atggctggcg aagagctaoo aatactgact gacaggtcac cttaaagcct 120 ctaggtgtgc caagtttgat ttatcttagg gactagaacc tagtottcta aatgtgattt 180 tgccttgctg tttogtcctg atgtgaaggt aaccacaoag agagattggg ctgcatcagt 240 aatgatatgc atacctttog tgcatcagtg agcttcttoc ctgttaactg tatgaccaca 300 aaatttagct ggagtaaata aatatgogac agaaatcctg gaacaagatg gtgaaattgc 360 ttaagaatcg agacttcagg gctcaatgac ctctgagcat gtttcccaaa gtgtgaccca 420 catgaccatc tgtctctcag tctcctggtc cctocgtaga gcttctgaaa ctgaatcttt 480 gtggggtggg ggtagcgttc aagaatcaaa agttgaacca agctctttgg gtgatactta 540 tgtatactga ggttcaggaa ctgctggaga gatgactggg caccaagagg atgacagtga 600 ctcagctggc atcccttagc tggttcatgg cagagctgag tgggcactcc tgtctctgac 660 cccagottca gtgctottta tctcctccat gcctcctcag tcgtgctgct ctaagactgc 720 ttactggctt tccttcatgt cotgggcaoa gagcagttct tttggtagca gatttgagtc 780 cacttccccc gtgoaoagat cactgctcag gacccagaga ggagcagctc tgctccagca 840 gggttttcca ttgoatcaca cacccaaacg gtaggatcca acagtcacac ttgaaagcaa 900 ccataattgt gaggtttctg atgctgtaga cttocttaca tttctcacaa cctagttaga 960 gagtcacatg ggggtgaagt gtggctogcg acctgcccca acaagtgcgt gcagaagcca 1020 ggaaacaaag gagtaaattc acttoaaatg ggatgcacat ggtgtcogtg atgaagagac 1080 acattcagaa ttgoccaagg acaggaaaat gaccagagag agccagagct gagctggtaa 1140 taaagagact ccgagactga gtggagttaa tgagggaagc atgcaaogag tggggcaatt 1200 tcagttggtt tctctcattg ctttaagcga aatgaactat acggacagga gaacagcctg 1260 cttgccccag tctctccttg gccgocctct gttgtccctg tcaactcagg tgcocacggt 1320 gctcagagga ggtgctggca aagcocotgg agoottatgt aggccatggg ggotcctaaa 1380 aggaacctga atgaatcatt tacagcaggt ctctcttgta aagcccagcc acagtaactc 1440 gtacactgac tgtttcaaaa gacagccttt cttaatoatt taattgttto atattcaaat 1500 atatctccta attgttttta ttttttcctg atotagaaga tatgacaaca gggtagaact 1560 tgggaagagg gaataggaag ctcgccottc ctccttccct octcccctct ctactttcot 1620 tccttccttg gtcatcaggt accttctttg tgcctgctgt tgtaggctac accctatgtt 1680 tggtggaagg caaaaagaaa aatcagtagg atacaactca gtagggaaga cagagatatt 1740 caagcccctt gtcctcccag tgtgataagt gtggtggttg aggtgtgaac aaggggctct 1800 gtgaacagag aggacgaaag aggagctcct cctgaggctg ttgggaaaag catcactgaa 1860 gagtgacttt cagaagaaga gaagaaaaag aggagaacat gcgtgatttt ataatgaaat 1920 agattagata aggggaaaaa aggcatttaa acaaggcaaa aagaacagga gaatagagaa 1980 gagatgtgga ggagaaggag cactgtagta aacacgcaga aggacaggaa cacttagaca 2040 tgcaacccao tcccaccctc cgtcttgggg gaggaaagca cactactgtc ccaaagaact 2100 aatactgaac cagtgctgcc ttgtggagag aggcatggoc aaggcgttca gagacctggg 2160 ootggtccca ccgotgccoa cagcactcag cctctgagca cagcctgggg tcatotgtgt 2220 gccctctggc caaggctgat ggtagttctc tgagtaattg agagtcattg cctgtctgtg 2280 cagtattgtg aaaacaagto accttttaac tttaaaacta ctttaaaaaa ctttaaagtt 2340 ttaaaaaaac ttatttaaaa actaotcatg agatgacagt ttctctgacc ctcagaggaa 2400 ggctgggotg cgcatacgtg aggaattttt acatgaacat cccaggactt gctgttcgoa 2460 ggtgataaac tgcacctccc caggactccc gctgoactca catgcagctc cctggacttc 2520 tggtatctga cccggcccat ttctgtgttt oaggggagaa tttggcttgc gggagtactc 2580 agaagttaag aoggtgacag taaagatccc ccagaagaac tcctaagaag gccaagaagg 2640 aggatgaagc ccagcctgca cgtctgtccc tctctgcttt ctctgtaggg cccagctctc 2700 aggaatacaa agttgagcca cggtccttac tlaaagattg aaaagataac atgtaggcca 2760 ggcaggtcac tgoacaacta aagcaaacca gctgggtaca gtttcttggc actctgtaag 2820 gggccacctt aatcataoca aatattgggg aaagtgggat aaagggagga ggaggagcta 2880 gcagacacat ccagtatctc cttctggagc acaggatgaa ataagggagc tgtattattt 2940 catgtctttg tcacaaagaa ctttcctctc aaggaaaggt gacctttctc otgtcttcat 3000 tttcctcctt ccaggccctc ctcgctcacc cacccctccc tctcttccaa ggagatgtca 3060 gctgagctca ttctggggca gatgtttggg ccgggaacaa tttttcaagg ttgtaaagcc 3120 aaattatcat ttcatgttat ccatttcttc aaagcaaaac atgaaatggt tttagctaga 3180 gtcagaccag aatgaaaatg ccaggagctg gtacactaca gatgtagtaa gaacctggga 3240 tattcctgac ccaatctggt tttcttttac ccataaataa catgaatgaa aaaagattgg 3300 gacaatagag actggaagtc atcatgtgca gttcaccgct tctgagcttg ctgcagtttt 3360 ggggtgtgtg tgtattagat tccttctcag ttattctgga ataaggcaag gagtgggttg 3420 tttttcatag ctagataaga tcttttccaa agtttttctt agaaccaacc aaaaaacaat 3480 ccgagtaggc ccgagaattt gataatgctg gatgccttgc agacatcatt cagtttctaa 3540 tattgggcaa caattattat taaatgaatt atttctgtag ttggaatctg taccttctga 3600 acctctacac caataactgc tgcaggtgtg attttggtct gtcacactgt acatctatca 3660 taatgtgccc tgtatctatt ggcagtgacc ttggaaaato tggocaagcc taggggtttc 3720 cttttccatt tgccaagttc cattgtgcca ggactgccgt gctccactga gctcctctgt 3780 cacacoccat tcttgcccct cactgggcag gccatggcct acagcttgca gggagtaaag 3840 caggcccgcc tccctttctt cccatccaca tactcctctt ctgctttcca gtgactooac 3900 cagtttgatg tgggaagtgt tagcttcctt tccttcttco atcccttctt ccatotttcc 3960 agctgtcaaa tccaatccag tctctaacct aaatgcagat catttattta aaagtaccaa 4020 acataaccca gagtatgtgg aatatgggca acatatatat agccttctgt atttaacgat 4080 cttctgcttc ttaaccgtac cagttttcta tttataactc ttatctatcc atgatgtttt 4140 aaagtctcca cttgctgtta tttacaaacg acagtgcatt cagoagccca gtgccgtgag 4200 ccctgacaga tgccgtattt ctgagtgctt ccatgtgaat gctgccctcc tgtagcatgt 4260 gtccaagtgg acatagccac taaccaacta gttacctttg gactgcaaca aaaaatgtga 4320 aaatgaagat ttatttcttt taatttactt aaaaagaaac ctctgtgcta gcaataaagc 4380 atttatattg tgcaaaaaaa aaaaaaaaaa aaaac 4415 <210> 47 <211 >453

<212> DNA <213> Homo sapiens <400> 47 tgaaaattta tataactgtt gttgataagg aacattatcc aggaattgat acgtttatta 60 ggaaaagata tttttatagg cttggatgtt tttagttctg actttgaatt tatataaagt 120 atttttataa tgactggtct tccttacotg gaaaaacatg cgatgttagt tttagaatta 180 caccacaagt atctaaattt ggaacttaca aagggtctat cttgtaaata ttgttttgca 240 ttgtctgttg goaaatttgt gaactgtcat gatacgctta aggtggaaag tgttcattgc 300 acaatatatt tttactgctt totgaatgta gacggaacag tgtggaagca gaaggctttt 360 ttaactcatc cgtttgccaa tcattgcaaa caactgaaat gtggatgtga ttgcotcaat 420 aaagctcgtc cccattgctt aagccttcaa aaa 453 <210> 48 <211> 1587

<212> DNA <213> Homo sapiens <400> 48 cttttagctg coagocctgg cccatcatgt agctgcagca cagccttccc taacgttgca 60 actgggggaa aaatcacttt ccagtctgtt ttgcaaggtg tgcatttcca tcttgattcc 120 ctgaaagtcc atctgctgca tcggtcaaga gaaaotcoac ttgcatgaag attgcacgcc 180 tgcagcttgc atctttgttg caaaactagc tacagaagag aagcaaggca aagtcttttg 240 tgctcccctc ccccatcaaa ggaaagggga aaatgtctca gtcgaaaggc aagaagcgaa 300 accctggcct taaaattcca aaagaagcat ttgaacaacc tcagaccagt tccacaccac 360 ctagagattt agactccaag gcttgcattt ctattggaaa tcagaacttt gaggtgaagg 420 cagatgacct ggagectata atggaactgg gacgaggtgc gtacggggtg gtggagaaga 480 tgcggcacgt gcccagcggg cagatcatgg cagtgaagcg gatccgagcc acagtaaata 540 gccaggaaoa gaaacggcta ctgatggatt tggatatttc catgaggacg gtggactgtc 600 cattcactgt caccttttat ggcgcactgt ttcgggaggg tgatgtgtgg atctgcatgg 660 agctcatgga tacatcacta gataaattct acaaacaagt tattgataaa ggccagaoaa 720 ttccagagga oatcttaggg aaaatagcag tttctattgt aaaagcatta gaacatttac 780 atagtaagct gtctgtcatt cacagagacg tcaagccttc taatgtactc atcaatgctc 840 tcggtcaagt gaagatgtgc gattttggaa tcagtggcta cttggtggac tctgttgcta 900 aaacaattga tgcaggttgc aaaccataca tggcccctga aagaataaac ccagagctca 960 acoagaaggg atacagtgtg aagtctgaca tttggagtct gggcatcacg atgattgagt 1020 tggccatcot tcgatttccc tatgattcat ggggaactcc atttcagcag ctcaaaoagg 1080 tggtagagga gccatcgcca caactcccag cagacaagtt ctctgoagag tttgttgact 1140 ttacctcaca gtgcttaaag aagaattcca aagaacggcc tacataccca gagctaatgc 1200 aacatccatt tttcacccta catgaatcca aaggaacaga tgtggcatct tttgtaaaao 1260 tgattcttgg agactaaaaa gcagtggact taatcggttg accctactgt ggattggtgg 1320 gtttcggggt gaagcaagtt cactacagca tcaatagaaa gtcatctttg agataattta 1380 accctgcctc tcagagggtt ttctctccoa attttctttt tactccccct cttaaggggg 1440 ccttggaatc tatagtatag aatgaaotgt ctagatggat gaattatgat aaaggcttag 1500 gacttcaaaa ggtgattaaa tatttaatga tgtgtcatat gaaaaaaaaa aaaaaaaaaa 1560 aaaaaaaaaa aaaaaaaaaa aaaaaaa 1587 <210> 49 <211> 558

<212> DNA <213> Homo sapiens <400> 49 cagtcocacc atgtattttg ctttgtttct aaaaagcttt ttaaaaactg ttatttaata 60 ccaaagggag gaatcgtatg ggttcttctg cccaccgttg tgactaagaa tgcacaggga 120 cttggttctc gttgcacctt tttttagtaa catgtttcat ggggacccac tgtacagccc 180 ttcattctgc tgtgtcagtt tggootggcc tgacaotggo tgccccagcg gggaccacgg 240 aagcagagtg agagcottcg ctgagtcaat gctaccttca gccccagacg catcccattt 300 ccatgtcttc catgctcact gctcatgcac tttttacacg gtttcttcca aacagcccgg 360 tcttgatgca ggagagtctg gaaaaggaag aaaatggttt cagtttcaaa attcaaagga 420 aaaagttgag gacttatttt gtcctgtcaa gattgcaaga acatgtaaaa tgtacggagc 480 ttcataatac gttatattgt tccgaagcag ctcgttgaga aacatttgtt ttoaataaca 540 ttttagctta aaaaaaaa 558 <210> 50 <211 > 841

<212> DNA <213> Homo sapiens <220> <221 > misc_feature <222> (54)..(54) <223> a or g or c or t/u <400> 50 tcacctcgtg gcgtagggga gaggtaacac cgagaagagg cagcggcggt ggcncagaga 60 cgattggtgc caaacagggc agaacgcaac tcagctctgg gtttgtgaat agcacaatgg 120 aagaagctgg actttgtggg ttaagagaga aagcagatat gttgtgtaac tctgaatcao 180 atgatattct tcaacatcaa gactcaaatt gcagtgccac aagtaataaa catttattgg 240 aagatgaaga aggccgtgac tttataacaa agaacaggag ttgggtgagc ccagtgcact 300 gcacacaaga gtcaagaagg gagcttcctg agcaagaagt agcccctccg tctggtcagc 360 aagctttaca attgcaacag gaacaaagaa aaagtcttag gaaaagaagt tttattattg 420 atgcaagccc taaacaotct ttccgactcc agaggagaag ctggcagctc tctgtaagaa 480 atatgctgat cttggaaatt cacctcttct atagaagagt ttgttttgaa ctatacgatt 540 tgaaacaaaa ttcttttttt ggagactatg gaaacattct caacagggaa accctactag 600 actttgtaaa gcaaataatg gaaaagatac agaacttttt gaagaatcat gggaaatttt 660 tataattaaa taaatgctaa aattctgttt tgtgaaacat ttatgggaat tatcactgac 720 agtttttgta cactttcaaa tagtgttaaa gcagcaactc catgttgtaa atgcacaaaa 780 caaatattta gttaataatc aactccaaga ataaagctgt aacaataata gttaaaaaaa 840 a 841 <210>51 <211 >2384

<212> DNA <213> Homo sapiens <400> 51 ggcacgaggg tcagcagccg ccagacttco tgocgaagtc cgagccccct cccggggctg 60 gaggggggca agcgggttcc gaggtgcaaa gcctggtgcc ocgagccctg cggagctcgg 120 ggccagcatg gcccccacgc tgcaacaggc gtaocggagg cgctggtgga tggoctgcac 180 ggctgtgctg gagaacctct tcttctctgc tgtactcctg ggctggggct ccctgttgat 240 cattctgaag aacgagggct tctattccag cacgtgccca gctgagagca gcaccaacac 300 cacccaggat gagcagcgca ggtggccagg ctgtgaccag caggacgaga tgctcaacct 360 gggcttcacc attggttoct tcgtgctcag cgcoaccacc ctgccactgg ggatcctcat 420 ggaccgcttt ggcccccgac ccgtgcggct ggttggoagt gcctgcttca ctgcgtcctg 480 caccctcatg gccctggcct cccgggacgt ggaagctctg tctccgttga tattcctggc 540 gctgtccctg aatggctttg gtggcatctg cctaacgttc actteactca cgctgcccaa 600 catgtttggg aacctgcgct ccacgttaat ggccctcatg attggctctt aogcctcttc 660 tgccattacg ttcccaggaa tcaagctgat ctacgatgcc ggtgtggcct tcgtggtcat 720 catgttcacc tggtctggcc tggcctgcct tatctttctg aactgcaccc tcaactggcc 780 catcgaagcc tttcctgccc ctgaggaagt caattacacg aagaagatca agctgagtgg 840 gctggocctg gaccacaagg tgacaggtga cctcttctac accoatgtga ccaocatggg 900 ccagaggctc agccagaagg cccccagcct ggaggacggt tcggatgcct tcatgtcacc 960 ccaggatgtt cggggcacct cagaaaacct tcctgagagg tctgtcccct tacgcaagag 1020 cctctgctcc cccactttcc tgtggagcct cctcaccatg ggcatgaccc agctgcggat 1080 catcttctac atggctgctg tgaacaagat gctggagtac cttgtgactg gtggccagga 1140 gcatgagaca aatgaacagc aacaaaaggt ggcagagaca gttgggttct actcctccgt 1200 cttcggggcc atgcagctgt tgtgccttot cacctgcccc ctcattggct acatcatgga 1260 ctggoggatc aaggactgcg tggacgcccc aactcagggc actgtcctcg gagatgccag 1320 ggacggggtt gctaccaaat ccatcagacc acgctactgc aagatccaaa agctcaccaa 1380 tgccatcagt gccttcaccc tgaccaacct gctgcttgtg ggttttggca tcacctgtct 1440 catcaacaac ttacacctcc agtttgtgac otttgtcctg cacaccattg ttcgaggttt 1500 cttccactca gcctgtggga gtctctatgc tgcagtgttc ccatccaacc actttgggac 1560 gctgacaggc ctgcagtccc tcatcagtgc tgtgttcgcc ttgcttcagc agccactttt 1620 catggcgatg gtgggacccc tgaaaggaga gcccttctgg gtgaatctgg gcctoctgct 1680 attctcactc ctgggattco tgttgccttc ctacctcttc tattaccgtg cccggctcca 1740 gcaggagtac gocgccaatg ggatgggccc actgaaggtg cttagcggct ctgaggtgac 1800 cgcatagact tctoagaoca agggacctgg atgacaggca atcaaggcct gagoaaccaa 1860 aaggagtgcc ccatatggct tttctacctg taacatgoac atagagccat ggccgtagat 1920 ttataaatac caagagaagt tctatttttg taaagaotgc aaaaaggagg aaaaaaaacc 1980 ttcaaaaacg ccccctaagt caacgotcca ttgactgaag aoagtoccta tcctagaggg 2040 gttgagcttt cttcctcctt gggttggagg agaccagggt gcctcttatc tccttctagc 2100 ggtctgcctc ctggtacctc ttggggggat cggcaaacag gotacccctg aggtcccatg 2160 tgccatgagt gtgcacacat gcatgtgtct gtgtatgtgt gaatgtgaga gagacacagc 2220 cctcotttca gaaggaaagg ggcctgaggt gccagctgtg tcctgggtta ggggttgggg 2280 gtcggcccct tccagggcca ggagggcagg ttccctctct ggtgctgctg cttgcaagtc 2340 ttagaggaaa taaaaaggga agtgagaaaa aaaaaaaaaa aaaa 2384 <210> 52 <211> 1923

<212> DNA <213> Homo sapiens <400> 52 ggcacgaggg aggcggcggc tccagccggc gcggcgcgag gctcggcggt gggatccggc 60 gggcggtgct agctccgcgc tccctgcctc gctcgctgcc gggggcggtc ggaaggcgcg 120 gcgcgaagcc cgggtggccc gagggcgcga tggctgctcc tgtcccgtgg gcctgctgtg 1 SO ctgtgcttgc cgccgccgcc goagttgtct acgcccagag acacagtcca caggaggcac 240 cccatgtgca gtacgagcgc ctgggctctg acgtgacact gccatgtggg acagcaaact 300 gggatgctgc ggtgacgtgg cgggtaaatg ggacagacot ggcccctgac ctgctcaacg 360 gctctcagct ggtgctccat ggcctggaac tgggccacag tggcctctac gcctgcttcc 420 accgtgactc ctggoacctg cgccaccaag tcotgctgca tgtgggottg ccgcogcggg 480 agcctgtgct cagctgccgc tcoaacactt accccaaggg cttctactgc agctggoatc 540 tgcccacccc cacctacatt cccaacacct tcaatgtgac tgtgctgcat ggctccaaaa 600 ttatggtctg tgagaaggac ccagccctca agaaccgctg ccacattcgc tacatgcacc 660 tgttctccac catcaagtac aaggtctcca taagtgtcag caatgccctg ggccacaatg 720 ccacagctat cacctttgac gagttcacca ttgtgaagcc tgatcctcca gaaaatgtgg 780 tagcccggcc agtgcccagc aaccctcgcc ggctggaggt gacgtggcag accccctcga 840 cctggcctga ccctgagtct tttcctctca agttctttct gogctaccga cocctcatcc 900 tggaccagtg gcagcatgtg gagctgtcog acggcacagc acacaccatc acagatgoot 960 acgccgggaa ggagtacatt atccaggtgg cagccaagga caatgagatt gggacatgga 1020 gtgactggag cgtagccgcc caogotacgc cctggactga ggaaccgcga cacctcacca 1080 cggaggccca ggctgcggag accacgacca gcaooaocag ctccctggca cocccaoota 1140 ccacgaagat ctgtgaccct ggggagctgg gcagcggcgg gggaccctcg gcacccttct 1200 tggtcagcgt ccccatcact ctggccctgg ctgccgctgc cgccactgcc agcagtctct 1260 tgatctgagc ccggcacccc atgaggacat gcagagcacc tgcagaggag caggaggccg 1320 gagctgagcc tgcagacccc ggtttctatt ttgcacacgg gcaggaggac cttttgcatt 1380 ctcttcagac acaatttgtg gagaccccgg cgggcocggg Gctgccgccc cccagooctg 1440 ccgcaccaag ctggccctcc ttcctccctc aggggaggtg ggccatgcag ctaacccaoc 1500 caccaaagac cccctcaccc tggccccttg ggctggaccc tccaatgcca gcgactccca 1560 ggagcccttg ggggacgtga ggggagcctc tcacatocga tttctcctco tgcocoagco 1620 tcctgtctat cccagggtct ctgttgccac catcagatta taagotcctg atgctggggg 1680 ggcccagcca tccccctccc cccagcaccc acaattttca gtoccotccc ctotgccotg 1740 ttttgtatac ccctcccctg accctgctcc tatcccaoag tatttaatgc cctgtcagtc 1800 ccttctagtc tgactcaatg gtaacttgctgtatttgaattttttataga tgtatataca I860 gggtgggggg agtgggcggt tctcattaaa cgtcaocatt tcatgaaaaa aaaaaaaaaa 1920 aaa 1923 <210> 53 <211 >2065

<212> DNA <213> Homo sapiens <400> 53 .ggcacgagga gtttcataat ttocgtgggt cgggccgggc gggccaggcg ctgggcacgg 60 tgatggceac caotggggcc ctgggcaact actacgtgga ctogttootg ctgggcgcog 120 aogccgcgga tgagctgagc gttggccgct atgcgccggg gacoctgggc cagcctcccc 180 ggcaggcggc gacgctggcc gagcaccccg acttcagccc gtgcagcttc cagtccaagg 240 cgacggtgtt tggcgcctcg tggaacccag tgcacgcggc gggcgecaac gctgtacccg 300 ctgcggtgta ccaccacoat caccaccacc cotacgtgca cccccaggcg cccgtggcgg 360 cggcggcgcc ggacggcagg tacatgcgct cctggctgga gcccacgccc ggtgcgctct 420 ccttcgcggg cttgccctcc agccggcctt atggcattaa acctgaaccg ctgtcggcca 480 gaaggggtga ctgtcccacg cttgacactc acactttgtc cctgactgac tatgcttgtg 540 gttctcctcc agttgataga gaaaaacaac ccagcgaagg cgccttctct gaaaacaatg 600 ctgagaatga gagcggcgga gacaagcccc ccatcgatcc caataaccca gcagccaact 660 ggcttcatgc gcgctccact cggaaaaagc ggtgccccta tacaaaacac cagaccctgg 720 aaotggagaa agagtttctg ttcaacatgt acctcaccag ggaccgeagg tacgaggtgg 780 ctcgactgct caaoctoacc gagaggcagg tcaagatctg gttccagaac cgcaggatga 840 aaatgaagaa aatcaacaaa gaccgagcaa aagacgagtg atgccatttg ggcttattta 900 gaaaaaaggg taagctagag agaaaaagaa agaactgtcc gtcccccttc cgccttctcc 960 ottttctcac ccccacccta gcctccacca tccccgcaoa aagcggctct aaacctcagg 1020 ccacatcttt tccaaggcaa aocotgttca ggotggctog taggcctgcc gctttgatgg 1080 aggaggtatt gtaagctttc cattttctat aagaaaaagg aaaagttgag gggggggcat 1140 tagtgctgat agctgtgtgt gttagcttgt atatatattt ttaaaaatct aoctgttoct 1200 gacttaaaac aaaaggaaag aaactacctt tttataatgc acaactgttg atggtaggct 1260 gtatagtttt tagtctgtgt agttaattta atttgcagtt tgtgcggcag attgctctgc 1320 caagatactt gaacactgtg ttttattgtg gtaattatgt tttgtgattc aaacttctgt 1380 gtactgggtg atgcacccat tgtgattgtg gaagatagaa ttcaatttga actcaggttg 1440 tttatgaggg gaaaaaaaca gttgcataga gtatagctct gtagtggaat atgtottctg 1500 tataactagg ctgttaacot atgattgtaa agtagctgta agaatttcco agtgaaataa 1560 aaaaaaattt taagtgttct cggggatgoa tagattcatc attttctcca ccttaaaaat 1620 gcgggcattt aagtctgtcc attatctata tagtcctgtc ttgtctattg tatatataat 1680 ctatatgatt aaagaaaata tgcataatoa gacaagcttg aatattgttt ttgcaccaga 1740 cgaacagtga ggaaattcgg agctatacat atgtgcagaa ggttactacc tagggtttat 1800 gcttaatttt aatcggagga aatgaatgct gattgtaacg gagttaattt tattgataat 1860 aaattataca ctatgaaacc gccattgggc tactgtagat ttgtatcctt gatgaatctg 1920 gggtttccat cagactgaac ttacactgta tattttgcaa tagttacctc aaggcctact 1980 gaccaaattg ttgtgttgag atgatattta actttttgcc aaataaaata tattgattct 2040 tttctaaaaa aaaaaaaaaa aaaaa 2065 <210> 54 <211 > 1045

<212> DNA <213> Homo sapiens <400> 54 aaaccagtgt atccagtcat ggaaaagaag gaggaagatg gcaccctgga gcgggggcac 60 tggaacaaca agatggagtt tgtgctgtca gtggctgggg agatcattgg cttaggcaac 120 gtctggaggt ttccctatct ctgctaoaaa aatgggggag gtgagatgag agcccttgtg 180 ccaccccacc cactcctgga aggaggatac ttccatctcc tgcacttacg gcccctctgg 240 ggagtcocat agatgtatag aattctggag gtaggaggac gcttggaggt cattaaggac 300 actctgtaag agactaagac ctagaaaggt tacgtgaota tcccagggct ctttctatta 360 taacgtggca tcgtagaaat atgagcacaa gctggaacca ggtggatgag agtttggatt 420 ctggctctgc tacttaacac tctgtgtgat cttggacaag ttacttaagc tctcagagca 480 tcaattgccg ctcctgcaaa ttgagataat aatgcctgcc tttcaaggtc attgtaagga 540 ttagagacaa tgtgtgtaaa gcacttaata aatagtagot otgctgatga tgacgttgat 600 aaccaaactg ttctgtggtc ttaagtaata aatagtagct otgctgatga tgacgttgat 660 aaccaaactg ttctgtggtc ttaagtaata agtagtagct ctgttgatga tgacgttgat 720 aaccaaactg ttctgtggtc ttaagtaata agtagtagct otgctgatga tgacgttgat 780 aaccaaactg ttctgtggtc ttaagtaata aatagtagct otgctgatga tgatgttgat 840 aaccaaactg ttctgtggtc ttaagtaata aatagtagct otgctgatga tgacgttgat 900 aaccaaactg ttctgtggtc ttaagtaata aatagtagct otgctgatga tgacgttgat 960 aaccaaactg ttctgtggtc .ttaagtaata aatagtagct ctgctgatga tgacgttgat 1020 aaaaaaaaaa aaaaaaaaaa aaaaa 1045 <210> 55 <211 >2024

<212> DNA <213> Homo sapiens <400> 55 ggaagacatc aggatgtacc atctgccctt ctgtcggacc ccagggtacg tcccatgagc 60 gcggccgagc tgcgtcgagg gcagcagagc gtgctgcact gctcagggac ccggactctg 120 cagtttctcc tgcactgttt tcacctttgg ccagacgggc tctgggaaga cctacaccct 180 gactggaccc cctccccagg gggagggggt gcctgtaccc cccagcctgg ctggcatcat 240 gcagaggacc ttcgcctggc tgttggaccg cgtgcagcac ctgggtgccc ctgtcaccct 300 tcgcgcctct tatctggaga tctacaatga gcaggttcgg gacttgctga gcctggggtc 360 tccccggccc ctccctgttc gctggaacaa gactcggggc ttctatgtgg agcagctgcg 420 ggtggtggaa tttgggagtc tggaggccct gatggaactt ttgcaaacgg gtctcagccg 480 tcgaaggaac tcagcccaca ccctgaacca ggcctccagc cgaagccatg ccctgctcac 540 cctttacatc agccgtcaaa ctgcccagca gatgccttct gtggaccctg gggagccccc 600 tgttggtggg aagctgtgct ttgtggacct ggcaggcagt gagaaggtag cagccacggg 660 atcccgtggg gagctgatgc ttgaggctaa cagcatcaac cgaagcctgc tggccctggg 720 tcactgcatc tccctgctgc tggacccaca gcggaagcag agccacatcc ctttccggga 780 cagcaagctc accaagttgc tggcagactc actgggaggg cgcggggtca ccctcatggt 840 ggcctgcgtg tccccctcag cccagtgcct tcctgagact ctcagcaccc tgcgatatgc 900 aagccgagct cagcgggtca ccacccgacc acaggccccc aagtctcctg tggcaaagca 960 gccccagcgt ttggagacag agatgctgca gctccaggag gagaaccgtc gcctgcagtt 1020 ccagctggac caaatggact gcaaggcctc agggctcagt ggagcccggg tggcctgggc 1080 ccagcggaac ctgtacggga tgctacagga gttcatgcta gagaatgaga ggctcaggaa 1140 agaaaagagc cagctgcaga atagccgaga cctggcccag aatgagcagc gcatcctggc 1200 ccagcaggtc catgcactag agaggcgtct cctctctgcc tgctaccatc accagcaggg 1260 tcctggcctg accccaccgt gtccctgctt gatggcccca gctccccctt gccatgcact 1320 gccacccctc tactcctgcc cctgctgcca catctgccca ctgtgtcgag tgcccctggc 1380 ccactgggcc tgcctgccag gggagcacca cctgccccag gtgttggacc ctgaggcctc 1440 aggtggcagg cccccatctg cccggccccc accctgggca cccccatgca gccctggctc 1500 tgccaagtgc ccaagagaga ggagtcacag tgactggact cagacccgag tcctggcaga 1560 gatgttgacg gaggaggagg tggtaccttc tgcacctccc ctgcctgtga ggcccccgaa 1620 gacatcacca gggctcagag gtggggccgg ggttccaaac ctggcccaga gactggaggc 1680 cctcagagac cagattggca gctccctgcg acgtggccgc agccagccac cctgcagtga 1740 gggcgcacgg agcccaggcc aagtcctccc tccccattga aggccaagtg ggaacccagg 1800 agactgctgt gtgacctcag actgggctcc acactcttgg gcttcagtct gcccatctgc 1860 tgaatggaga cagcagctgc tactccacct gcagctgggc taggggcggg gactgggggt 1920 gctatttagg ggaacaaggg gattcaggag aaaccaggca gcaggggatg aaatacatga 1980 ataaagagag gcatcagctc caaaaaaaaa aaaaaaaaaa aaaa 2024 <210> 56 <211 >3334

<212> DNA <213> Homo sapiens <400> 56 ctccccctga gagaggctgg gcagcacccc ccttctgcca ggagtgccag ccaaggtgcc 60 agacccctgt ccagtggcaa gctggaaggc tttcagagca tcgatgaagc tatagcctgg 120 ctcaggaagg aactgacgga gatgcggctg caggaccagc aactggccag acagctcatg 180 cgcctgcgtg gcgacatcaa caagctgaaa atcgaacaca cctgccgcct ccacaggagg 240 atgctcaacg atgccaccta cgagctggag gagcgggatg agctggccga cctcttctgt 300 gactcccctc ttgcctccte. cttcagcctc tcpacaccac tcaagcttat tggcgtgacc 360 aagatgaaca tcaactctcg gaggttctct ctctgctgag gagccctcag actgggcgga 420 ggggctggag cggagggctt gggctggagg ggtgtcagag gaagctgagg ccaagttact 480 ccagtgggtc tcccggaggc aggggtccct gggactggcg actcaagggc cccaggacct 540 attcagtggt gctctccoac ccaggggccc tgggtgtgga tgccagtgtc tctgtgactg 600 gctcttgctt actaoccaaa gagctctgca gaagggccgc tccaaccaag atgttaaagg 660 agacctgggt tcccaccata atccatccct ccacggtcac gttcctgttt cctggaatca 720 ctggtgctat gaactgggat tcccaaaggg aggcccccca acaaagctgt catttttgca 780 gaaggctgtc ccgcaagggc cttgggggaa attaggcatg tcagatgtgc ctgtctoaog 840 tgctgttgct gtcctctaag tattgtctca aattcaccot aagtacatga ctcagcaaoa 900 ttgacaggga gctactagga agggaaaatc gaaaggcatg acaaatgggc acttggggac 960 gcagcoccag tggctggcag ccagtgtctc tggtgagcct gacactacaa ggctgtgtaa 1020 attgtaaatt ctggcgtgtg ctgggacatg tgatgggggc actagcgtag cttgggtgca 1080 acaagcaoag atgtccccat tgtctccoct ggccacatgc atctccaaag agcctcttca 1140 ctgccaccca caccccaggg tgacagcctg ggagaccact ggtgactgaa ccaggcaggt 1200 cctgaaagca ttttccataa ctgaattctc otgcaggggc gtgaccgggg cctcctggtg 1260 gattotggtg gtgtcacott actgccctct ctggaaagac aatctaggga gcccagaggc 1320 ccatcctgag cctcctctga gattttgtgc ctgacctaaa caactagttt taataagact 1380 gttactgatg tgttgttcac ttgttagtaa ctgatttttg tccaaatgcg gaagccactt 1440 gtgtaggtoa actacagtgc gtaggatttg attttaagag tttctccctc ooaacaggct 1500 tgaggatcag caagttaaga occcagcagg ttagggaggt cagtctgggg tcatacggca 1560 tggcaggggt ccctcggcca gacccgtaga atcctgagat aaggagtgtt tctgaccttt 1620 ggtgtcatet agtcgagtcc tctcattagt aaaggagcaa agtgaaacct gggggaggag 1680 aaggacttco ctcaggttgc acagctgttt aggctataga atattgatgt gtgaaaccat 1740 tattgataat gcotagtaga tcacatgtca atgaacttga accccaaaga tggtcgtgat 1800 gctttgooaa acccgcacao tgcoaacccc tctactctcc acctcagccc ccacccacat 1860 ctccoagagt attgcaattc agaacatttg ggtcaaggtg gagcaaggoa ctgacagtgg 1920 coocacaggg catgtgtcac taatcaotgt cccatggtct acgcacggca totggctgct 1980 ctgtctactg tgacttcttc ctgtgtaatc toagtggggc ccgtgtccac coaoacatog 2040 tgacccacat aggggagagg ttgcttttct tttgtgggct gagagtagga caatgcaaat 2100 gaatgatotc tagtagacag aaaagaactt ggtctctttt ttaaaattto aaagagccag 2160 aagttctatg cctccttcaa agtaggcaga acaacgcagc caagatctac tgtctgccat 2220 gctctgtgca atgaagtotg caggcctgag gaccatgtac tgctgtcctt cctcagagct 2280 otgcacaaac actgccaagt cctgaagacg cattcctttc ctgccaacct ctttccagat 2340 aagcccttga ggtctcgggc tgacctacac acacacacac acacacacac acacacacac 2400 acacccccac acacacacac acacgacaga gaacatgcca taaacatcct tgaacccatg 2460 caggaaagcc catcccatat tctgaaaaaa tgccaaatta ggtttttctt tctttttgga 2520 aatcagtcat tacagtaacc gaaaccattg ggttcagcga aaatggaaag atttagctga 2580 atgtagtcag tccaattaag ttggatgcaa ctgagtgatt tagttgcttg ggtaacccag 2640 tgcttgcttg ctttcttcat tctctgggtg gaaactaaga tcaagacaca tgtttgggga 2700 taagttaaat gtctgagcta ttttgctcgg tttatcctaa gagaacttta ttatgggatg 2760 aggaggtgac ccaagatgag aagtggaggg ggacagcgat gttttctaaa catcgtccag 2820 tgttgactgg cttccttact ttgcacagtg aacacaacta accacattaa ttcagctttg 2880 tgaagtccct gctctctgtg ggttctatga gtcagcagca acattggcct aacctccgtc 2940 ccagcctcct ggctcacca'c atgtgtacag tgctgtttgc agttgtactc attatccatc 3000 catctctctg ccatccccaa gcatcgctgg gtgtaaaacg caaactctcc accgacactg 3060 ccatgcgtgg tcatgtcttg atgccttcag gggctcagta gctatcaaag aggcctggag 3120 ggcctgggca ggcttgacga tgcctgaccg agttcaagac ccacaccctg tagcaatacc 3180 aagtgctatt acataatcaa tggacgattt atacttttat tttttatgat tatttgtttc 3240 tatattgctg ttagaaaaag tgaaataaaa atacttcaaa agaaaaaaaa aaaaaaaaaa 3300 aaaaaaaaaa aaaagaaaaa aaaaaaaaaa aaaa 3334 <210> 57 <211> 573

<212> DNA <213> Homo sapiens <220> <221 > misc_feature <222> (567)..(569) <223> a or g or c or t/u <400> 57 tgaaggaccg cgatcctaaa gagattgaat gggacgacct ggcccagctg cccttcctga 60 ccatgtgcgt gaaggagagc ctgaggttac atcccccagc tcccttcatc tcccgatgct 120 gcacccagga cattgttctc ccagatggcc gagtcatccc caagggcatt acctgcctca 180 tcgatattat aggggtccat cacaacccaa ctgtgtggcc ggatcctgag tctacgaccc 240 cttccgcttt gacccagaga acagcaaggg gaggtcacct ctggctttta attcccttct 300 ccgcagggcc caggaactgc atcgggccag cgtttcccat ggcggagatg aaagtggttc 360 ctggcgttga tgctgctgca cttccggttc ctgccagacc acactgagcc ccgcaggaag 420 ctggaactga tcattgcggc cgagggcggg ctttggctgc gggtggagcc cctgaatgta 480 ggcttgcagt gactttctga cccatccacc tgtttttttg cagattgtca tgaataaaac 540 ggtgctgtca cctcaaaaaa aaaaaannna aaa 573 <210> 58 <211 >2534

<212> DNA <213> Homo sapiens <400> 58 gagtcctctc gttggtcccg gaggtggggt tgcgctcaca aggggcgacc gtcgccacgg 60 tggcggccac tgcatcgcgt cccacctccg cggccctggg cgccgtggtg tcgacgggcc 120 ccgagcctat gacgggccag ggccagtcgg cgtccgggtc gtcggogtgg agoacggtat ISO tccgccacgt ccggtatgag aacctgatag cgggcgtgag cggcggcgtc ttatccaacc 240 ttgogctgca tecgctcgac ctcgtgaaga tccgcttcgc cgtgagtgat ggattggaac 300 tgagaccgaa atataatgga attttacatt gcttgactac catttggaaa cttgatggac 360 tacggggact ttatcaagga gtaaccccaa atatatgggg tgcaggttta tcctggggac 420 tctacttttt cttttacaat gccatcaagt catataaaac agaaggaaga gctgaacatt 480 tagaggcaac agaatacctt gtctcagctg ctgaagctgg agccatgacc ctctgcatta 540 caaacccatt atgggtaaca aaaactcgoc ttatgttaca gtatgatgct gttgttaact 600 ccccacaccg acaatataaa ggaatgtttg atacacttgt gaaaatatat aagtatgaag 660 gtgtgcgtgg attatataag ggatttgttc ctgggctgtt tggaacatcg catggtgccc 720 ttcagtttat ggcatatgaa ttgctgaagt tgaagtacaa ccagcatatc aatagattac 780 cagaagccca gttgagcaca gtagaatata tatctgttgc agcactatcc aaaatatttg 840 ctgtcgcagc aacataccca tatcaagtcg taagagctcg tottcaggat oaacacatgt 900 tttacagtgg tgtaatagat gtaatcacaa agacatggag gaaagaaggc gtcggtggat 960 tttacaaggg aattgctcct aatttgatta gagtgactcc agcctgctgt attacctttg 1020 tggtatatga aaacgtctca cattttttac ttgaccttag agaaaagaga aagtaagctc 1080 aaagaggaca attccagtat atctgcccaa ggcagcaaca agctcttttg tgtttaaggc 1140 ataaaagaag aattctgcat agaaacatgg ctcatattcg aaattgctct atagtcatta 1200 gaagccagag aactgctaag tctcctgcaa tgtttttctt gctttttgcc ttccccatat 1260 atatggaact tggctacctc tgcctgaaat ggctgccatc aacacaatgt taaaaotgac 1320 aogaaggata gagtttcaca gatttctacg ttttattggt ggaagctgat ttgcaacatt 1380 tgctaaatgg attagatgaa tgtaottctt tttgtgagct tacttgootg gattgcttta 1440 aaattaacct ttgtgcaata ccaagaaaat agctctttaa aagaatgtct ttgtatgtct 1500 oaaggtaaat taaggattta ctgaataagg tgttgacoaa atccagacca ttttatttta 1560 tttttttatt tatttatttt ttgagatgga gtcttgcttt gtcgcccagg ctggagtgca 1620 gtggcgtgat ctcagctcac tgcaacctcc acotcccggg ttcacgccat tctcctgcct 1680 cagcctcctg agtagctggg actacaggca cctgocacca cgcctggcta actttttttt 1740 atattttgag tagaaatggg gtttcaccat gttagccagg atggtctcaa tctcctgacc 1800 ttgtgatccg cctgccttgg cctcccaaag tgctgggatt acaggcgtga gccactgcgc 1860 ctggccagac cattttagaa ttgggaaatt ttagtgagaa aaaatgcact gtaaatatgc 1920 tttagtttta attcagttgg gatgcactac ctagcgaaaa ttgagaaact atatacttct 1980 cagagaaata tctgacatct attgtcattc cattgctatt ttttttcccc agagacttcc 2040 ataatttaaa ataaaatcct agatccagtt cttgtttttt ggcataaata cttaatctat 2100 tttaaattta taaaatctga gcttctagga tccagctgtg tcaaccttta tttagcatat 2160 ataactataa atcacttatt acagatgcta aatagatcac cttttacaga tgctgaaatg 2220 tttgggatat gtttgttgac aaggtaaatg gaaatgagaa actttatact tcagttttca 2280 gatatatgga tctagatccc aaataaatga ttaatcttca ttggtttctc aaattcaggt 2340 tgaaatacaa attaatagcc tttattgatt ttacttttat gagtcattgt agacatctat 2400 aaatataaaa gggcctgtac ccaaaggatg ccagaalaot agtattttta tttatogtaa 2460 acatccacga gtgctgttgc actaccatct atttgttgta aataaaagtg ttgttttcaa 2520 aaaaaaaaaa aaaa 2534 <210> 59 <211> 1232

<212> DNA <213> Homo sapiens <400> 59 ctagaggggc ggaaagtaac aaggaggtgg gggtacaaat cctcagctcc tgcttccgca 60 agcactaacc tgctctgaag tgagccaggc agctctggcc atcttttccc agccacagaa 120 tcaggtgatg gtccagaatt aagagctgtc acctgtgtca ttcactcaca atggaagaaa 180 tgaagaagac tgccatccgg ctgcccaaag gcaaacagaa gcctataaag acggaatgga 240 attcccggtg tgtcottttc acctacttco aaggggacat cagcagcgta gtggatgaac 300 acttctccag agctctgagc aatatcaaga gcccccagga attgaccccc tcgagtcaga 360 gtgaaggtgt gatgctgaaa aacgatgata gcatgtctcc aaatcagtgg cgttactcgt 420 ctccatggac aaagccacaa ccagaagtac ctgtcacaaa ccgtgccgcc aactgcaact 480 tgcatgtgcc tggtcccatg gctgtgaatc agttctcacc gtccotggct aggagggcct 540 ctgttcggcc tggggagctg tggcatttct octccotggc gggoaccagc tccttagagc 600 ctggctactc tcatcccttc cccgctcggc acctggttcc agagccccag cctgatggga 660 aacgtgagcc tctcctaagt ctcctooagc aagacagatg cotagcccgt cctcaggaat 720 ctgocgccag ggagaatggc aaccctggco agatagctgg aagcaoaggg ttgctcttca 780 acctgcctcc cggctcagtt cactataaga aactatatgt atotcgtgga tctgccagta 840 ccagccttcc aaatgaaact ctttcagagt tagagacacc tgggaaatac tcacttacac 900 caccaaacca ctggggccac ccacatcgat acctgcagca tctttagtca agttggagga 960 gaaagacaac acttggtcta agacacggoa gcaagacatc cctgcatatt gttccagata 1020 aaaatgaaag ctgctcacac ccacttgcct ccccaatctg ttaaacagct tcgtgtctag 1080 tatgagotca gtacttgccc tgtgaaaatc ccagaagccc ccgctgtcaa tgttccccat 1140 ccacaccctg cttgctcctg tgtaacagct cagatgatga ataataataa aactgtactt 1200 ttttggatgg tgaaaaaaaa aaaaaaaaaa aa 1232 <210> 60 <211 > 3551 <212> DNA <213> Homo sapiens <400> 60 ttgccttgtg ttagctagca ataagaaaag aagctttgtt tggattaaca tatataccct 60 cttcattctg catacctatt ttttccccaa taatttgcag cttaggtccg aggacaccac 120 aaactctgct taaagggcct ggaggctctc aaggcatggc cagacgctct gtcttgtact 180 tcatcctgct gaatgctctg atcaacaagg gccaagcctg cttctgtgat cactatgcat 240 ggactcagtg gaccagctgc tcaaaaactt gcaattctgg aacccagagc agacacagac 300 aaatagtagt agataagtac taccaggaaa acttttgtga acagatttgc agcaagcagg 360 agactagaga atgtaactgg caaagatgcc ccatcaactg cctcctggga gattttggac 420 catggtcaga ctgtgaccct tgtattgaaa aacagtctaa agttagatct gtcttgcgtc 480 ccagtcagtt tgggggacag ccatgcactg agcctctggt agcctttcaa ccatgcattc 540 catctaagct ctgcaaaatt gaagaggctg actgcaagaa taaatttcgc tgtgacagtg 600 gccgctgcat tgccagaaag ttagaatgca atggagaaaa tgactgtgga gacaattcag 660 atgaaaggga ctgtgggagg acaaaggcag tatgcacacg gaagtataat cccatcccta 720 gtgtacagtt gatgggcaat gggtttcatt ttctggcagg agagcccaga ggagaagtcc 780 ttgataactc tttcactgga ggaatatgta aaactgtcaa aagcagtagg acaagtaatc 840 cataccgtgt tccggccaat ctggaaaatg tcggctttga ggtacaaact gcagaagatg 900 acttgaaaac agatttctac aaggatttaa cttctcttgg acacaatgaa aatcaacaag 960 gctcattctc aagtcagggg gggagctctt tcagtgtacc aattttttat tcctcaaaga 1020 gaagtgaaaa tatcaaccat aattctgcct tcaaacaagc cattcaagcc tctcacaaaa 1080 aggattctag ttttattagg atccataaag tgatgaaagt cttaaacttc acaacgaaag 1140 ctaaagatct gcacctttct gatgtctttt tgaaagcact taaccatctg cctctagaat 1200 acaactctgc tttgtacagc cgaatattcg atgactttgg gactcattac ttcacctctg 1260 gctccctggg aggcgtgtat gaccttctct atcagtttag cagtgaggaa ctaaagaact 1320 caggtttaac cgaggaagaa gccaaacact gtgtcaggat tgaaacaaag aaacgcgttt 1380 tatttgctaa gaaaacaaaa gtggaacata ggtgcaccac caacaagctg tcagagaaac 1440 atgaaggttc atttatacag ggagcagaga aatccatatc cctgattcga ggtggaagga 1500 gtgaatatgg agcagctttg gcatgggaga aagggagctc tggtctggag gagaagacat 1560 tttctgagtg gttagaatca gtgaaggaaa atcctgctgt gattgacttt gagcttgccc 1620 ccatcgtgga cttggtaaga aacatcccct gtgcagtgac aaaacggaac aacctcagga 1680 aagctttgca agagtatgca gccaagttcg atccttgcca gtgtgctcca tgccctaata 1740 atggccgacc caccctctca gggactgaat gtctgtgtgt gtgtcagagt ggcacctatg 1800 gtgagaactg tgagaaacag tctccagatt ataaatccaa tgcagtagac ggacagtggg 1860 gttgttggtc ttcctggagt acctgtgatg ctacttataa gagatcgaga acccgagaat 1920 gcaataatcc tgccccccaa cgaggaggga aacgctgtga gggggagaag cgacaagagg 1980 aagactgcac attttcaatc atggaaaaca atggacaacc atgtatcaat gatgatgaag 2040 aaatgaaaga ggtcgatctt cctgagatag aagcagattc cgggtgtcct cagccagttc 2100 ctccagaaaa tggatttatc cggaatgaaa agcaaciata cttggttgga gaagatgttg 2160 aaatttcatg ccttactggc tttgaaactg ttggatacca gtacttcaga tgcttaccag 2220 acgggacctg gagacaaggg gatgtggaat gccaacggac ggagtgcatc aagccagttg 2280 tgcaggaagt cctgacaatt acaccatttc agagattgta tagaattggt gaatccattg 2340 agctaacttg ccccaaaggc tttgttgttg ctgggccatc aaggtacaca tgccagggga 2400 attcctggac accacccatt tcaaactctc tcacctgtga aaaagatact ctaacaaaat 2460 taaaaggcca ttgtcagctg ggacagaaac aatcaggatc tgaatgcatt tgtatgtctc 2520 cagaagaaga ctgtagccat cattcagaag atctctgtgt gtttgacaca gactccaacg 2580 attactttac ttcacccgct tgtaagttct tggctgagaa atgtttaaat aatcagcaac 2640 tccattttct acatattggt tcctgccaag acggccgcca gttagaatgg ggtcttgaaa 2700 ggacaagact ttcatccaac agcacaaaga aagaatcctg tggctatgac acctgctatg 2760 actgggaaaa atgttcagcc tccacttcca aatgtgtctg cctattgccc ccacagtgct 2820 tcaagggtgg aaaccaactc tactgtgtca aaatgggatc atcaacaagt gagaaaacat 2880 tgaacatctg tgaagtggga actataagat gtgcaaacag gaagatggaa atactgcatc 2940 ctggaaagtg tttggcctag cacaattact gctaggccca gcacaatgaa cagatttacc 3000 atcccgaaga accaactcct acaaatgaga attcttgcac aaacagcaga ctggcatgct 3060 caaagttact gacaaaaatt attttctgtt agtttgagat cattattctc ccctgactct 3120 cctgtttggg catgtcttat tcagttccag ctcatgacgc cctgtagcat acccctaggt 3180 accaacttcc acagcagtct cgtaaattct cctgttcaca ttgtacaaaa ataatgtgac 3240 ttctgaggcc cttatgtagc ctgtgacatt aagcattctc acaattagaa ataagaataa 3300 aacccataat tttcttcaat gagttaataa acagaaatct ccagaacctc tgaaacacat 3360 tcttgaagcc cagctttcat atcttcattc aacaaataat ttctgagtgt gtatacagga 3420 tgtcaagtac tgaccaaagt cctgagaact cggcagataa taaaacagac aaaagccttt 3480 gccttcatga agcatacatt cattcagggg tagacacaca aaaaatgaaa taaacaggta 3540 aaatatgtag c 3551 <210 61 <211 > 1673

<212> DNA <213> Homo sapiens <400 61 ctctcctcgc ccgctgggtg ctgaagttgg gcggatggca gcaaaccggc tccgctagag 60 gacogagccg cccagccccg ctcccccgga cccatcggcg cgctgcocac acctccaggc 120 gaccggccaa ctgggtcctg aagtagctga aatgcgaaaa aggcagcagt ccoaaaatga 180 aggaacacct gccgtgtctc aagotoctgg aaaccagagg cccaacaaca cctgttgctt 240 ttgttggtgo tgttgttgca gctgctcctg cctcactgtg aggaatgaag aaagagggga 300 aaatgcggga agacccacac acactacaaa aatggagagt atccaggtcc tagaggaatg 360 ccaaaacccc actgcagagg aagtcttgtc ctggtctcaa aattttgaca agatgatgaa 420 ggccooagca ggaagaaacc ttttcagaga gttcctccga acagaataca gtgaagagaa 480 cctacttttc tggcttgctt gtgaagactt aaagaaggag cagaacaaaa aagtaattga 540 agaaaaggot aggatgatat atgaagatta catttctafa ctatcaccaa aagaggtcag 600 tcttgattct cgagttagag aggtgatcaa tagaaatctg ttggatocca atcctcacat 660 gtatgaagat goccaacttc agatatatac tttaatgcac agagattctt ttccaaggtt 720 tttgaactct caaatttata agtcatttgt tgaaagtact gctggctctt cttctgaatc 780 ttaatgttca tttaaaaaca atcattttgg agggctgaga tgggaaataa aagtagttaa 840 ataacatcag aaactgagtt cctggagaac tacagtttag cattcctcag gctactgtga 900 aaacacaacc gttatggtct ttgtctccat ttttatcaag gttttccatg gttaagtttg 960 gagaaaatao cacacaaaac aatgaattgc caaattgttt gttttattca agactcattc 1020 tacttgcaag caaagtgtat ttgtagtcct atgaacagtc tcctcgtgta tctccagaga 1080 ctgcatgtgc aaagtaaaat gcttcatttg ccacatagtt gttgtaatat ttaatccagt 1140 agcataactt atatctgtat ttaaggactt ttgtgcaata tggtcttaag aaataattgc 1200 caaaaaaatc ggccatggtt ctgcattttt aacataatct aagacagaaa aaaagcaatt 1260 tttactatgt aacaatggta ttcaacattc tatatactgt gtttagtaca ctaattttga 1320 agccaatatt tctgtacatg aaaaagagct atttatctct gtttgttgga aaatcctaat 1380 ggggattcct ctggttgttc aotgccaaaa ctgtggcatt ttcattacag gagagtttao 1440 tatgctaaaa gcaaaaaaca aaaaaaaaaa aaaagggaag aaggaaaaaa gcaaaaaaca 1500 atttgaagat atcctatctc aatgacaaat caaaagagtg atattgcttt taactgtaat 1560 agaagaaaat gaatttatgt atatatoaga tgtccaatac tgtaattaat ttattaaaga 1620 otggctctoc agttttaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 1673 <210> 62 <211> 1867

<212> DNA <213> Homo sapiens <400> 62 aaaagaacca ggattgcatt tgaagttaag ctgcaaaaaa ccagtcgatc aacagatttt 60 cgagtcccac agtcaatatg caocatgttt aatgttatgg ttgatgccaa agctoaatca 120 acaaaacttt gcagcatgga aatgggccaa gagtttgcta aaatgtggca tcaataccat 180 toaaaaatag acgaactaat tgaagaaact gttaaagaaa tgataacact cttggttgca 240 aagttcgtta ctatcttgga aggagtgctg gcaaaattat ccagatatga cgaagggaot 300 ttgttttctt cttttctgtc atttacogtg aaggcagott ccaaatatgt ggatgtacct 360 aaacccggga tggacgtggc cgacgcctao gtgactttcg tocgocattc tcaggatgtc 420 ctgcgtgata aggtcaatga ggagatgtac atagaaaggt tatttgatca atggtacaac 480 agctcoatga acgtgatctg cacctggttg acggaccgga tggacttaca gottcatatt 540 tatcagttga aaacactaat taggatggta aagaaaacct acagagattt ccgattgoaa 600 ggggtcctgg actccacctt aaacagcaag acctatgaaa cgatcoggaa ccgtctcact 660 •gtggaggaag ccacagcatc agtgagtgaa ggtgggggac tgcagggoat cagcatgaag 720 gacagcgatg aggaagacga agaagacgat tagaccattt ggtcctagag tctgctggga 780 cagagtcctg taatcagtgc atgtccttag tctgttagtt aaacccatta ggaattttct 840 gtcaactacc atgcccatga gatgtttatc aatacaactg ccattttagc tatgtggtac 900 caagattagc aaatgacctt catatccact gatttcctga tgtccatgtc tatatgttta 960 caagcaatat ggagcaccat tctttaaata ctgttcatgg agaatacata gtctaaccac 1020 taggcgtgtc cctgttatca gcaaagatca atgatgcttc attcatgtac tatgtatgca 1080 ttggtggtaa atggatgtga gggcaagtac atcaagtaca ttcactctgt ttcacgtatg 1140 tggatgccag ttaattaaat gagtacgtaa ataaattaat taaaacaoat agatctgctt 1200 tgtgttttta tttttatttt ttgaaaaaca aaaggcaagt ctccaacaat taacttttga 1260 tgctttctgt toccctaaaa ccaaaaaatg aaccccttgt gtcgttgtta acccatoctt 1320 tcatttactc atataattag ccaaaaaaaa aaggatggct acataccaat ggattgattc 1380 tcttaattgc cacggcaagg gggcgatcct atcatgactt aacatcaagc gcgcagttca 1440 aaactactgt cttctgtcaa agttttctcc tcttaaatgt tattttgctt ttacgtctca 1500 actgtgtatg taaaaaaaac gaatatttaa attacaacoc tagactaaaa atgtgtttat 1560 aataagatgt ggatatttcc ttcagtagat tgtaaccata atttaaatta ttttgttcca 1620 cactgttttt tatatctgtc atgtacattg cattttgatc tgtaactgca caaccctggg 1680 gtttgctgca gagctatttc tttccatgta aagtagtgga tccatcttgc ttttgcctta 1740 tataaagcct acagttatgg aagtgtggaa aactgtggct tctcaataaa tattcagatg 1800 tcctaagaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1860 aaaaaaa 1867 <210> 63 <211> 601

<212> DNA <213> Homo sapiens <400> 63 acctgaactg tctaagatat tctaagcaaa gttgacaaag acaattctcc acttgagccc 60 ttaaaaatgt aaccactata aaggtttcac gcggtggttc ttattgattc gctgtgtcat 120 cacatcagct ccactgttgc caaactttgt cgcatgcata atgtatgatg gaggcttgga 180 tgggaatatg ctgattttgt tctgcactta aaggcttctc ctcctggagg gctgcctagg 240 gccacttgct tgatttatca tgagagaaga ggagagagag agagactgag cgctaggagt 300 gtgtgtatgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtat gtgtgtagcg ggagatgtgg 3 60 gcggagcgag agcaaaagga ctgcggcctg atgcatgctg gaaaaagaca cgcttttcat 420 ttctgatcag ttgtacttca tcctatatca gcaoagctgc catacttcga cttatcagga 480 ttotggctgg tggcctgcgo gagggtgcag tcttacttaa aagactttca gttaattctc 540 actggtatca tcgcagtgaa cttaaagcaa agacctctta gtaaaaaata aaaaaaataa 600 a 601 <210> 64 <211 > 367

<212> DNA <213> Homo sapiens <400> 64 gcttctcttt aaaattgacc caaggcatga gccactgcgc ctggccagca aatgcttttt 60 gtgcagaata cacttctttc aggcatlgtc aggtgctgtt ttgtttaagc tctaactoac 120 ccctggaata caggggaatg atgacaacca gcccagccag gcctgactca tcatggtcac 180 atccagcccc cacccccggc caactaacoa ctgcaggctc ctcttccaga ctcaccaggg 240 ggcctcgagg ccccggcatc tcccttggcc ctgggtgtgg gttttacaag actgtgtctt 300 tcatgacatc atagcccaac catgtgagaa gaaggagaag gccccccttt cttcattaat 360 ctgaaaa 367 <210> 65 <211 >2484

<212> DNA <213> Homo sapiens <400> 65 ggcacgagga agggoctgtg ggtttattat aaggcggagc tcggcgggag aggtgcgggc 60 cgaatccgag ccgagcggag aggaatccgg cagtagagag cggaotccag ccggcggacc 120 ctgcagccct cgcctgggac agcggcgcgc tgggcaggcg cccaagagag catcgagcag 180 cggaacccgc gaagccggcc cgcagccgcg acccgcgcag cctgccgctc tcccgccgcc 240 ggtccgggca gcatgaggcg cgcggcgctc tggctctggc tgtgcgcgct ggcgctgagc 300 ctgcagccgg ccctgccgoa aattgtggct actaatttgc cccctgaaga tcaagatggc 360 tctggggatg actctgacaa cttctccggc tcaggtgcag gtgctttgoa agatatcacc 420 ttgtcacagc agaccccctc cacttggaag gacacgcagc tcctgacggc tattcccacg 480 tctccagaac ccaccggcct ggaggctaca gctgcotcca cctccaccct gccggctgga 540 gaggggecca aggagggaga ggctgtagtc ctgccagaag tggagcctgg cctcaccgcc 600 cgggagcagg aggccacccc ccgacccagg gagaccacac agctcccgac cactcatcag 660 gcctcaacga ccacagccac cacggcccag gagcccgcca cctcccaccc ccacagggac 720 atgcagoctg gcoaccatga gacctcaacc cctgcaggac ccagccaagc tgaccttcac 780 actccccaca cagaggatgg aggtccttct gccaccgaga gggctgctga ggatggagcc 840 tccagtcagc tcccagcagc agagggctct ggggagcagg acttcacctt tgaaacctcg 900 ggggagaata cggctgtagt ggccgtggag cctgaccgcc ggaaccagtc cccagtggat 960 cagggggcca cgggggcctc acagggcctc ctggacagga aagaggtgct gggaggggtc 1020 attgccgtag gcctcgtggg gctcatcttt gctgtgtgcc tggtgggttt catgctgtac 1080 cgcatgaaga agaaggacga aggcagctac tccttggagg agcogaaaca agcoaacggc 1140 ggggcctacc agaagcccac caaacaggag gaattctatg cctgacgcgg gagccatgcg 1200 ccccctccgc cctgccactc actaggcccc cacttgcctc ttccttgaag aactgcaggc 1260 cctggcctcc cctgccacca ggccacotoc ccagcattco agcccctctg gtegctcctg 1320 cccaoggagt cgtggggtgt gctgggagct ccactctgct tctctgactt ctgcctggag 1380 acttagggca ccaggggttt ctcgcatagg acctttccac cacagccagc acctggcatc 1440 gcaccattct gaotcggttt ctccaaactg aagcagcctc tccccaggtc cagctctgga 1500 ggggaggggg atocgactgc tttggaccta aatggcctca tgtggctgga agatcctgcg 1560 ggtggggctt ggggctcaca cacctgtagc acttactggt aggaccaagc atcttggggg 1620 ggtggccgct gagtggcagg ggacaggagt ccactttgtt tcgtggggag gtctaatcta 1680 gatatcgact tgtttttgca catgtttcct ctagttcttt gttcatagcc cagtagacct 1740 tgttacttct gaggtaagtt aagtaagttg attcggtatc cccccatctt gcttccctaa 1800 tctatggtcg ggagacagca tcagggttaa gaagactttt tttttttttt tttttaaact 1860 aggagaacca aatctggaag ccaaaatgta ggcttagttt gtgtgttgtc tcttgagttt 1920 gtcgotoatg tgtgoaacag ggtatggact atotgtctgg tggccccgtt tctggtggtc 1980 tgttggcagg ctggccagtc caggctgccg tggggccgcc gcctctttca agcagtcgtg 2040 cctgtgtcca tgcgctcagg gccatgctga ggcctgggcc gctgccacgt tggagaagoc 2100 cgtgtgagaa gtgaatgctg ggactcagcc ttcagacaga gaggactgta gggagggcgg 2160 caggggcctg gagatcctco tgcagaccac gcccgtcctg cctgtggcgc cgtctccagg 2220 ggctgcttcc tcctggaaat tgacgagggg tgtottgggc agagctggct ctgagcgcct 2280 ccatccaagg ccaggttctc cgttagctcc tgtggcccca ccctgggccc tgggctggaa 2340 tcaggaatat tttccaaaga gtgatagtct tttgcttttg gcaaaactct acttaatcoa 2400 atgggttttt ccctgtacag tagattttcc aaatgtaata aactttaata taaagtaaaa 2460 aaaaaaaaaa aaaaaaaaaa aaaa 2484 <210> 66 <211> 1989

<212> DNA <213> Homo sapiens <400> 66 cggatgggga aaaaaaaaga tgtcagctcc tccgctgtag tattgctcct taaaaacccc 60 tctotctgaa aatgacatgc cctcgcaatg taactccgaa ctcgtacgcg gagcccttgg 120 ctgcgcccgg cggaggagag cgctatagcc ggagcgcagg catgtatatg cagtctggga 180 gtgacttcaa ttgcggggtg atgaggggct gcgggctcgc gccctcgctc tccaagaggg 240 acgagggcag cagccccagc ctcgccctca acacctatcc gtcctacctc tcgcagctgg 300 actcctgggg cgaccccaaa gccgcctatc gcctggaaca acctgttggc aggccgctgt 360 octcctgctc ctacccacct agtgtcaagg aggagaatgt ctgctgcatg tacagcgcag 420 agaagcgggc gaaaagtggc cccgaggoag ctctctactc ccaccccttg ccggagtcct 480 gccttgggga gcacgaggta cccgtgccca gctactaccg cgccagcccg agotactccg 540 cgctggacaa gacgccccac tgttctgggg ocaacgactt cgaagcccct ttcgagcagc 600 gggccagtct caacccgcgc gccgaacato tggaatcgcc tcagctgggg ggcaaagtga 660 gtttccctga gacccccaag tccgacagcc agacccccag ccccaatgaa atcaagacgg 720 agoagagcct ggcgggccct aaagggagoc cctcggagag cgaaaaggag agggccaaag 780 ctgccgactc cagcccagac acctcggata acgaagcgaa agaggagata aaggcagaaa 840 acaccacagg aaattggctg acagcaaaga gcggaaggaa gaagaggtgc ccctatacta 900 aacaccagac gctggaattg gagaaagaat ttctgttcaa tatgtatttg acgcgagagc 960 gccgcctgga gattagcaag accattaacc ttacagacag acaagtcaaa atctggtttc 1020 aaaatcgcag aatgaaactc aagaaaatga accgagagaa tcggatccgg gaactgacct 1080 ccaattttaa tttcacctga gagcgoggcc tctcctoctc ccttcccgct ccttcctctc 1140 cccgcccctc ctccctttgt gcctggtgat atattttttt ttcctccctg agtataaatg 1200 caatgcgact goaaaaaagg caaagacctc agactctcct tccaagggac ctgtggttcg 1260 tgctgcgaag atgcttccac ttaaagcatg agaaatgggg tgccgggatg tggggtgtgg 1320 tgtgtgocct catagatggg ggtgggagtg tggctggtgt gtgtgtcaaa ccctcactca 1380 cccacgcact cacacacagc attctgttct ccatgcaaag ttaagatcga atccatccgc 1440 ttgtagggga aaaaaaggaa aaaaattaac cagagagggt ctgtaatctc gcagagcaca 1500 ggcagaatog ttacttcctt gctgcatttc ctccttagao taatagacgt tttggaaagt 1560 tcggctagtg ttogtgtgtt tgtcgtagca cccagagcct ccaccaaacc ctctccatgt 1620 ctttacctcc cagtcgctct aagaatctgc ttgaagtctc gtatttgtac tgctttctgc 1680 ttttctcoca cccctcctag cacccccaca tcccccatct agtaacatct cagaaattto 1740 atccagagga acaaaaaaat taaaaataga acatagcaaa gcaaagacag aatgcccccc 1800 cccaaatatt gtcctgtccc tgtctgggag ttgtgttatt taaagatatt ctgtatgttg 1860 tatcttttgc atgtagcttc cttaatggag aaaaaaaaat cctaataaat ttccagaatc 1920 ataatcctca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1980 aaaaaaaaa 1989 <210> 67 <211> 2125

<212> DNA <213> Homo sapiens <400> 67 gcagtggcca cgagaggcag gctggctggg acatgaggtt ggcagagggc aggcaagctg 60 gcccttggtg ggcctcgtcc tgagcactcg gaggcactcc tatgcttgga aagctcgota 120 tgctgctgtg ggtccagcag gcgctgctcg ccttgctcct coccacactc ctggcacagg 180 gagaagccag gaggagccga aacaccacca ggcccgctct gctgaggctg tcggattacc 240 ttttgaccaa ctacaggaag ggtgtgcgcc ccgtgaggga ctggaggaag ccaaccaccg 300 tatccattga cgtcattgtc tatgccatcc tcaacgtgga tgagaagaat caggtgctga 360 ccacctacat ctggtaccgg cagtactgga ctgatgagtt tctcoagtgg aaccctgagg 420 actttgacaa catcaccaag ttgtocatoc ccacggacag catctgggtc coggacattc 480 tcatcaatga gttcgtggat gtggggaagt ctccaaatat cccgtacgtg tatattcggc 540 atoaaggcga agttcagaac tacaagcccc ttcaggtggt gactgcctgt agcotcgaca 600 tctaoaaott ooocttogat gtccagaact gctcgctgac cttcaccagt tggctgcaca 660 ccatocagga catcaacatc tctttgtggc gcttgccaga aaaggtgaaa tccgaoagga 720 gtgtcttcat gaaccaggga gagtgggagt tgctgggggt gctgccctac tttcgggagt 780 tcagcatgga aagcagtaac tactatgcag aaatgaagtt ctatgtggtc atccgccggc 840 ggcccctctt ctatgtggtc agcctgctac tgcccagcat cttcctcatg gtcatggaca 900 tcgtgggctt ctacctgccc cccaacagtg gcgagagggt ctctttcaag attacactcc 960 tcctgggcta ctcggtcttc ctgatcatcg tttctgacac gctgccggcc actgccatcg 1020 gcactcctct cattggtgtc tactttgtgg tgtgcatggc tctgctggtg ataagtttgg 1080 ccgagaccat cttcattgtg cggctggtgc acaagcaaga cctgcagcag cccgtgcctg 1140 cttggctgcg tcacctggtt ctggagagaa tcgcctggct actttgcctg agggagcagt 1200 caacttccca gaggccccca gccacctccc aagccaccaa gactgatgac tgctcagcca 1260 tgggaaacca ctgcagccac atgggaggac cccaggactt cgagaagagc ccgagggaca 1320 gatgtagccc tcccccacca cctcgggagg cctcgctggc ggtgtgtggg ctgctgcagg 1380 agctgtcctc catccggcaa ttcctggaaa agcgggatga gatccgagag gtggcccgag 1440 actggctgcg cgtgggctcc gtgctggaca agctgctatt ccacatttac ctgctggcgg 1500 tgctggccta cagcatcacc ctggttatgc totggtccat ctggcagtac gcttgagtgg 1560 gtacagccca gtggaggagg gggtacagtc ctggttaggt ggggacagag gatttctgct 1620 taggcccctc aggacccagg gaatgccagg gacattttca agacacagac aaagtcccgt 1680 gccctgtttc caatgccaat tcatctcagc aatcacaagc oaaggtctga acccttccac 1740 caaaaactgg gtgttcaagg cccttacacc cttgtcccac ccccagcagc tcaccatggc 1800 tttaaaacat gctctcttag atoaggagaa actcgggcac tccctaagtc cactctagtt 1860 gtggactttt ccccattgao cctcacctga ataagggaot ttggaattct gcttctcttt 1920 cacaactttg cttttaggtt gaaggcaaaa ccaactctct actacacagg cctgataact 1980 ctgtacgagg cttctctaac ccctagtgtc ttttttttct tcacctcact tgtggoagct 2040 tccctgaaca ctcatccccc atcagatgat gggagtggga agaataaaat gcagtgaaac 2100 cctaaaaaaa aaaaaaaaaa aaaaa 2125 <210> 68 <211> 574

<212> DNA <213> Homo sapiens <400> 68 tottcgotco tctaccccat aaaattccct acaaatgcaa aaattogaga tagaagaagc 60 cgtccctgaa attgctgtct aaoattcacc ggaaacctct ccataaaoaa ggagaaacga 120 atgcacacgc atttttgcta agaagcccgg gattaagatt taaggataca agctgaaaga 180 aaaaatgaaa aatgcttctc cgcgcgtcaa togaggggtg gatgcgocac gcagctgagc 240 coagctcaoa gccacgcgta agaccaaaag otgccatggg ttctgogcgo ggagaoctca 300 gagccgaaga gagaagtccc cgcgtcagaa acgctgcgga tgccaggtct tgaaaatgct 360 gacttotgag gctaagaatt atttcaaaga caaaaagaaa agactggtga ggaggccttc 420 cggtgcaagg gcgcctatcc gctaattttg gatggggaag tagggattat tcgtttaaat 480 tcaatcgcga gcaccaagtc ggactggccg gggatggaga agggcaaccc ccacctttag 540 aaaaataaaa gatctcgaag gccaaaaaaa aaaa 574 <210> 69 <211 >3697

<212> DNA <213> Homo sapiens <400> 69 agggagtgtt cccgggggag atactccagt cgtagcaaga gtctcgacca ctgaatggaa 60 gaaaaggaot tttaaccacc attttgtgac ttacagaaag gaatttgaat aaagaaaact 120 atgatacttc aggccoatct tcactccctg tgtcttctta tgctttattt ggcaactgga 180 tatggccaag aggggaagtt tagtggacoc ctgaaacoca tgacattttc tatttatgaa 240 ggccaagaac cgagtcaaat tatattccag tttaaggoca atcctcctgc tgtgactttt 300 gaactaactg gggagacaga caacatattt gtgatagaac gggagggact tctgtattac 360 aacagagcct tggacaggga aacaagatct actcacaatc tccaggttgc agccctggac 420 gctaatggaa ttatagtgga gggtocagtc cctatcacca tagaagtgaa ggacatcaac 480 gacaatcgac ccacgtttct ocagtcaaag tacgaaggct cagtaaggca gaactctcgc 540 coaggaaagc ccttcttgta tgtcaatgcc acagacctgg atgatccggc cactcccaat 600 ggccagcttt attaccagat tgtcatcoag cttccoatga tcaacaatgt oatgtacttt 660 cagatcaaca acaaaacggg agccatctct cttacccgag agggatctca ggaattgaat 720 cctgctaaga atccttccta taatctggtg atctcagtga aggacatggg aggccagagt 780 gagaattcct tcagtgatac cacatctgtg gatatcatag tgacagagaa tatttggaaa 840 gcaccaaaac ctgtggagat ggtggaaaac tcaactgatc ctcaccccat caaaatcact 900 caggtgcggt ggaatgatcc cggtgcacaa tattccttag ttgacaaaga gaagctgcca 960 agattcccat tttcaattga ccaggaagga gatatttacg tgactcagcc cttggaccga 1020 gaagaaaagg atgcatatgt tttttatgca gttgcaaagg atgagtacgg aaaaccactt 1080 tcatatccgc tggaaattca tgtaaaagtt aaagatatta atgataatcc acctacatgt 1140 ccgtcaccag taaccgtatt tgaggtccag gagaatgaac gactgggtaa cagtatcggg 1200 acccttactg cacatgacag ggatgaagaa aatactgcca acagttttct aaactacagg 1260 attgtggagc aaactcccaa acttcccatg gatggactct tcctaatcca aacctatgct 1320 ggaatgttac agttagctaa acagtccttg aagaagcaag atactcctca gtacaactta 1380 acgatagagg tgtctgacaa agatttcaag accctttgtt ttgtgcaaat caacgttatt 1440 gatatcaatg atcagatccc catctttgaa aaatcagatt atggaaacct gactcttgct 1500 gaagacacaa acattgggtc caccatctta accatccagg ccactgatgc tgatgagcca 1560 tttactggga gttctaaaat tctgtatcat atcataaagg gagacagtga gggacgcctg 1620 ggggttgaca cagatcccca taccaacacc ggatatgtca taattaaaaa gcctcttgat 1680 tttgaaacag cagctgtttc caacattgtg ttcaaagcag aaaatcctga gcctctagtg 1740 tttggtgtga agtacaatgc aagttctttt gccaagttca cgcttattgt gacagatgtg 1800 aatgaagcac ctcaattttc ccaacacgta ttccaagcga aagtcagtga ggatgtagct 1860 ataggcacta aagtgggcaa tgtgactgcc aaggatccag aaggtctgga cataagctat 1920 tcactgaggg gagacacaag aggttggctt aaaattgacc acgtgactgg tgagatcttt 1980 agtgtggctc cattggacag agaagccgga agtccatatc gggtacaagt ggtggccaca 2040 gaagtagggg ggtcttcctt gagctctgtg tcagagttcc acctgatcct tatggatgtg 2100 aatgacaacc ctcccaggct agccaaggac tacacgggct tgttcttctg ccatcccctc 2160 agtgcacctg gaagtctcat tttcgaggct actgatgatg atcagcactt atttcggggt 2220 ccccatttta cattttccct cggcagtgga agcttacaaa acgactggga agtttccaaa 2280 atcaatggta ctcatgcccg actgtctacc aggcacacag agtttgagga gagggagtat 2340 gtcgtcttga tccgcatcaa tgatgggggt cggccaccct tggaaggcat tgtttcttta 2400 ccagttacat tctgcagttg tgtggaagga agttgtttcc ggccagcagg tcaccagact 2460 gggataccca ctgtgggcat ggcagttggt atactgctga ccacccttct ggtgattggt 2520 ataattttag cagttgtgtt tatccgcata aagaaggata aaggcaaaga taatgttgaa 2580 agtgctcaag catctgaagt caaacctctg agaagctgaa tttgaaaagg aatgtttgaa 2640 tttatatagc aagtgctatt tcagcaacaa ccatctcatc ctattacttt tcatctaacg 2700 tgcattataa ttttttaaac agatattccc tcttgtcctt taatatttgc taaatatttc 2760 ttttttgagg tggagtcttg ctctgtcgcc caggctggag tacagtggtg tgatcccagc 2820 tcactgcaac ctccgcctcc tgggttcaca tgattctcct gcctcagctt cctaagtagc 2880 tgggtttaca ggcacccacc accatgccca gctaattttt gtatttttaa tagagacggg 2940 gtttcgccat ttggccaggc tggtcttgaa ctcctgacgt caagtgatct gcctgccttg 3000 gtctcccaat acaggcatga accactgcac ccacctactt agatatttca tgtgctatag 3060 acattagaga gatttttcat ttttccatga catttttcct ctctgcaaat ggcttagcta 3120 cttgtgtttt tcccttttgg ggcaagacag actcattaaa tattctgtac attttttctt 3180 tatcaaggag atatatcagt gttgtctcat agaactgcct ggattccatt tatgtttttt 3240 ctgattccat cctgtgtccc cttcatcctt gactcctttg gtatttcact gaatttcaaa 3300 catttgtcag agaagaaaaa cgtgaggact caggaaaaat aaataaataa aagaacagcc 3360 ttttccctta gtattaacag aaatgtttct gtgtcattaa ccatctttaa tcaatgtgac 3420 atgttgctct ttggctgaaa ttcttcaact tggaaatgac acagacccac agaaggtgtt 3480 caaacacaac ctactctgca aaccttggta aaggaaccag tcagctggcc agatttcctc 3540 actacctgcc atgcatacat gctgcgcatg ttttcttcat tcgtatgtta gtaaagtttt 3600 ggttattata tatttaacat gtggaagaaa acaagacatg aaaagagtgg tgacaaatca 3660 agaataaaca ctggttgtag tcagttttgt ttgttaa 3 697 <210> 70 <211 >2530

<212> DNA <213> Homo sapiens <400> 70 aaatccttct tccaatgttc ctcccctctc tgtatgaacc ctgtgttggg gggcagaaga 60 tggaagccct tggcaagotc gatcgaacca agctactaaa ttgctgagct cgttttaact 120 gaagtgtgag aaggaggttt aaggcaagta gacaacatcc tgttgttggg gtgcttctct 180 cttttttgca catctggctg aactgggagt caggtggttg acttgtgcct ggctgcagta 240 gcagcggcat ctcccttgca cagttctcct cctcggcctg occaagagtc caccaggcca 300 tggacgcagt ggctgtgtat catggcaaaa tcagcaggga aaccggcgag aagctcctgc 360 ttgccactgg gctggatggc agctatttgc tgagggacag cgagagcgtg ccaggcgtgt 420 actgcctatg tgtgctgtat cacggttaca tttatacata ccgagtgtcc cagacagaaa 480 caggttcttg gagtgctgag acagcacctg gggtacataa aagatatttc cggaaaataa 540 aaaatctcat ttcagoattt cagaagccag atcaaggcat tgtaatacct ctgoagtato 600 cagttgagaa gaagtcctca gctagaagta cacaaggtac tacagggata agagaagatc 660 ctgatgtctg cctgaaagcc ccatgaagaa aaataaaaca ccttgtactt tattttctat 720 aatttaaata tatgctaagt cttatatatt gtagataata cagttcggtg agctacaaat 780 gcatttctaa agccattgta gtcctgtaat ggaagcatct agcatgtcgt caaagctgaa 840 atggaotttt gtacatagtg aggagctttg aaacgaggat tgggaaaaag taattccgta 900 ggttattttc agttattata tttacaaatg ggaaacaaaa ggataatgaa tactttataa 960 aggattaatg tcaattcttg coaaatataa ataaaaataa tcctcagttt ttgtgaaaag 1020 ctccattttt agtgaaatat tattttatag ctactaattt taaaatgtct tgcttgattg 1080 tatggtggga agttggctgg tgtcccttgt ctttgccaag ttctccacta gctatggtgt 1140 cataggctot tttgggattt ttgaagctgt atactgtgtg otaaaacaag caotaaacaa 1200 agagtgaagg atttatgttt aattctgaaa gcaaccttct tgcctagtgt tctgatattg 1260 gacagtaaaa tccacagacc aacctggagt tgaaaatatt ataatttaaa atatgctcta 1320 aacatgttta tcgtatttga tgctacagga tttgaaattg tattacaaat ccaatgaaat 1380 gagtttttct tttcatttac ctctgcccca gttgtttcta otacatggaa gacctcattt 1440 tgaagggaaa tttcagcagc tgcagetcat gagtaactga tttgtaacaa gcctoctttt 1500 aaagtaaccc tacaaaacca ctggaaagtt tatggttgta ttatttttta aaaaaattcc 1560 aagtgattga aacctacacg agatacagaa ttttatgcgg cattttcttc tcacatttat 1620 atttttgtga ttttgtgatt gattatatgt cactttgcta cagggctcac agaattcatt 1680 cactcaacaa acataatagg gcgctgaggg catagaagta aaaacacctg gtccctgctc 1740 tcagttcact gtcttgttgg acgagaaaag aaacaataac gataaaagac agtgaaagaa 1800 aataacgata aaagacagtg aaagaaaata acaataaaag acaaggaaaa aataacaatg 1860 aaagttgata agtaoatgat aagcgaggtt ccccgtgtgt aggtagatot ggtctttaga 1920 ggcagataga taggtcagtg caaatactct ggtccatggg ccatatgaaa aggctaagct 1980 tcactgtaaa ataataactg ggaattctgg attgtgtatg ggtgttggtg aacttggttt 2040 taattagtga actgctgaga gacagagcta ttctccatgt actggcaaga cctgatttct 2100 gagcatttaa tatggatgcc gtgggagtac aaaagtggag tgtggcctga gtaatgcatt 2160 atgggtggtt taccatttct tgaggtaaaa gcatcacatg aaottgtaaa ggaatttaaa 2220 aatcctactt tcataataag ttgcataggt ttaataattt ttaattatat ggcttgagtt 2280 taaattgtaa taggcgtaac taattttaac tctataatgt gttcattctg gaataatcct 2340 aaacatatga attatgtttg catgttcact tccaagagcc tttttttgaa aaaaagcttt 2400 ttttgaatca tcaagtcttt cacatttaaa taaagtgttt gaaagcttta tttaaaaaaa 2460 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2520 aagaaaaaaa 2530 <210>71 <211> 601

<212> DNA <213> Homo sapiens <400> 71 aattgttttc taagtaattg ctgcctctat tatggcactt catttttgca ctgtcttttg 60 agattcaaga aaaatttcta ttcttttttt tgcatccaat tgtgcctgaa cttttaaaat 120 atgtaaatgc tgccatgttc caaacccatc gtcagtgtgt gtgtttagag ctgtgcaccc 180 tagaaacaac atattgtccc atgagcaggt gcctgagaca cagacooctt tgcattcaca 240 gagaggtcat tggttataga gacttgaatt aataagtgac attatgccag tttctgttct 300 ctcacaggtg ataaacaatg ctttttgtgc actacatact cttcagtgta gagctcttgt 360 tttatgggaa aaggctcaaa tgccaaattg tgtttgatgg attaatatgc ccttttgccg 420 atgcatacta ttactgatgt gactcggttt tgtcgcagct ttgctttgtt taatgaaaca 480 cacttgtaaa cctcttttgc actttgaaaa agaatccagc gggatgctcg agcacctgta 540 aacaattttc tcaacctatt tgatgttcaa ataaagaatt aaactaaaaa aaaaaaaaaa 600 a 601 <210> 72 <211> 1286

<212> DNA <213> Homo sapiens <400> 72 ggogccgcgg acgctgctgg agtcgcctgg caaogatgto gcotggcaac tgaataggtt 60 ggccagtggc gcgggotact ggaagcagaa agggctgcgg aggcagtgag tggtttctgc 120 agagottcat ttggaaaggc ctctgtagtt ggggaaagat ggcccattcc cagaactcct 180 tggagcttcc oattaacatc aatgocaocc agattaccac tgcctatggc catcgggcoc 240 tgcccaagct gaaggaggag ctgcagtcag aggacctoca gacgaggcag aaagccotca 300 tggccctgtg tgacctcatg catgaccccg agtgtatota caaggccatg aacataggct 360 gtatggagaa cctgaaagct ttgctgaagg atagcaaoag tatggtgcgo ataaagacca 420 ccgaggtgct ccacatcacg gcaagccata gcgtgggcag atacgccttt ctagagcacg 480 acatcgtcct tgccctgtcc ttcctgctga atgaccccag cccagtctgc cgggggaacc 540 tgtacaaggc atacatgcag ctggtccagg tgcctagagg ggcccaagag atcatcagca 600 aaggtctgat ttcctoactg gtatggaagc tgoaggtgga ggtggaggag gaggagttco 660 aggagttcat cctggacaca ctggtcctct gcotgcagga ggatgccaco gaggccctgg 720 gcagcaatgt ggtgcttgtc ctgaagcaga agctcctoag cgccaacoag aacatccgca 780 gcaaggccgc ccgtgcgctc cttaatgtca gcatatctcg agagggcaag aaacaggtgt 840 gtcattttga cgtcatcccc atcctggtcc atctgctgaa agacccagtg gagcatgtga 900 agtctaacgc tgccggtgcc ctgatgttcg ccacagtgat cactgaaggg aagtatgcgg 960 ccctggaggc acaagccatc ggcctgctcc tggagctgct gcactccccc atgaccatag 1020 cgcgcctgaa tgccaccaag gcccttacca tgctggcaga ggcccccgag ggccgcaagg 1080 ccctgcagac gcacgtgccc actttccgtg ccatggaggt ggagacttac gaaaagcctc 1140 aagtggccga agccttacag cgggcagccc ggatcgccat cagtgtcatc gagttcaaac 1200 cctgagccct tcattcacct ctgtgagtga ataaatgtgc taagtctctt taaaaaaaaa 1260 aaaaaaaaaa aaaaaaaaaa aaaaaa 1286 <210> 73 <211 >2651

<212> DNA <213> Homo sapiens <400> 73 agagcagtaa gcttgtgata aaggccaatt ocaggtagct cttgaaggtg atagccatct 60 actttccagt ggctgccaac caoagggagt gcoagttaao actggaagga ttaaggcaag 120 gtcccttctc ttgagactcc cctctgagat ctgaaaaatg aagtggctta ggaacatcag 180 cagtgaagaa ctgccaagag ttggtgaagg ttgtctcttc cgagggcctt ctgaagacag 240 ggctcttgaa cagacaagtg gaagggctgt accagggata aaggaaagaa gtgcctgtcc 300 agcagggagc ttgaatttaa gttccatgta tgaagtcatt ggctctatct gcatttttct 360 gtcattctct tcatttgttt taaggtggaa aattttctta cagttgatgo aaagtatcaa 420 ctactttacc ctaccttctc cccttttaga tgggttcttc ctgagttttg gagtcttgta 480 tgattatcag tattcccctg tcaaaatcaa atctattcag gtttcttcac tgttgagaac 540 acctaaatgt ttttattttt gagaagtggg gacagagtct cactatgtca cccaggctgg 600 agtgcaatgg catgatctca gctcactgca accttcgcct cctgggttca agcgattetc 660 ctgcctccgc ctcctgagta gctgggatta taggoacgca ccaccacgcc cagctaattt 720 tttgtatttt tagtagagac agagtttcac catgttggcc aggctggtct tgaactcctg 780 accttgtgat ccacccacct cggcctccca gagtgctggg attacaggca tgagccacca 840 cgcttggcta agaacaceta aatttttatg tttcttggct caaaaaccag ttccatttct 900 aatgttgtcc tcacaagaag gctaattggt ggtgagacag caggggagga ggaagagctg 960 tggtttgtaa cttgttcaac tcaggcaata agcgatttta gctttattta aagtcttctg 1020 tocagcttta agcactttgt aagacatggc tgaaagtagc ttttctatca gaattgcaga 1080 tagtcatgtt gggctaacag tcaattggat atattccttt acctcacatg accccagcaa 1140 ctgtggtggt atctagaggt gaaacaggca agtgaaatgg acacctctgc tgtgaatgtt 1200 ttagagaagg aaattcaaaa aatgttgtaa ctgaaagcac tgttgaatat gggtatcggc 1260 tttctttttc actttgactc ttaacattat cagtcaactt ccacattaat gaaagttgac 1320 catagttatt tccaaataaa aagaaaccaa ctcttaccag gtcttggact gtgatgtcat 1380 attattcagt tttatgcttg ttcotgagca gaactcataa gagtgacata gtcagctgct 1440 gacggcacct cagccacgcc actcttactc agttcagtgg gtgtgcttgc gtggtaggat 1500 gtggtgcagc cctctctacg ctcttctatt tttggtatat ttcctatcta accttoaaat 1560 agcttccaat tctttttttc ttggactggc ttcattctga atttgtgota aaataatctt 1620 tcataaagag acctcagttt atagcgtaac agactacaca atgcactgat gttttcataa 1680 tgtttaaggg accoaotgca agaagcttgc tgcctccttt taattgtatt catttagatt 1740 ttgattttcc atgttaagaa ggtgaggtcc atgttggtgc ccttcagagt agagaaccat 1800 gtaaacatta ggaatgaaca gaggccttag gaatgaatag agagtttgcc ttatacaatt 1860 tcctgttaca aagctctccc tctcatgcaa agtagggaac accttttgag catctttgaa 1920 tttgacaaat ggtgctgttg caaacaottt ttttttgaga tgaagtctcg cggttgtcac 1980 ccgggctgga gtgcagtggc gtgatctcgg ctcactgcaa cttccacctc ctgggttcca 2040 gcagttotcc tgcctcagcc tcccaagtag ctgagattac aggcgcctgc caccccacct 2100 ggctgatttt tgtaatttta gtagagacgg ggtttcacca tgttggccag gctgattaac 2160 tcctgacctc aggtgatcca cctttctcgg cctcccaaag tgctgggatt acgggtgtga 2220 gccaccgtgc ccggcctgca aacacatttt aattgacaac actagggctg ttgtacaaaa 2280 tagtaatgat agccatggaa gttttacctt attctgtgag aagtgttctt aaacttatta 2340 agtgtctaaa ctaaggttta gtgctttttt aaaggaaagt tgtcccagga ttcatcotaa 2400 agaaagcaaa agttaattca actgatccac caatggaatt agatgggtag agttgggttc 2460 ttgagtttta ccaccactta gttcccactg aattttgtaa cttcctgtgt ttgcatcctc 2520 tgttcctatt ctgcccttgc tctgtgfcat otoagtcatt tgacttagaa agtgocctto 2580 aaaaggaccc tgttcactgc tgcacttttc aatgaattaa aatttattto tgttctaaaa 2640 aaaaaaaaaaa 2651

<210> 74 <211 >3403 <212> DNA <213> Homo sapiens <400> 74 tgatcaacaa ctgtcagctc ccagtcagag agaaagggcc tcttcagtct gtctoaggag 60 actgggagaa acagcataaa ggaccccaca aggaagggag aggtaccctg ggtcaggcgo 120 ttgtggagag agggcttcgc atgtaaagtg acgtcaggga aaatagaaca gaaaaaaagc 180 cagggccago ccagaggcac ctgagaagaa tcagacccac agctcagccc agocctggca 240 cagagaagag acaggcctgg cagcaoccag ggaccccctt tcctcagcct ccacctgcag 300 gacagcagga gcactgatgc gctgaaggta cgttctggag tctggaagca gcagaactga 360 aggaagtaaa cacgggtgtc tgggaagaoc cctoaagctg cagtaaagcc caggactgaa 420 ttggccacct gaggccaagg gtggcactcc aacctcctcc taaaggctgg ctagagocao 480 aggaaagggc cagaagccag agaaagggca aaggtggacc cctgcctcca aacctcctct 540 ggagactgac ctcctctttc ctgtgcctta ttgtttctec ctcttctott tgttcgccac 600 tgggcggtga cctcagggat cctggcctaa cctggtgatt gtgcaggcaa ctgtgtcoga 660 gaagaccctt ctctggaaga ttgaacccca attcagccat ggtgactcct ttgatgtcaa 720 actggtaagg gctgagccgt gggcacagga taccactcct tcoagctott ctgctgtgac 780 ctgcccatgg aagtccctgt ggacacgaaa tcctgtttgg atcatctaac tggaggctct 840 ctgttcttca cctccacgcg ccctcttgac cccaggaggt tcaggggagg aagtacgcca 900 ctctccactg gcaocctcct tggcctacac agagtcacoo ctgagcccct caatgtgtgc 960 tgaggtgggc cctgctctct gcaggggtat ggagagaaat agcttggggt gctgtgaggc 1020 cccgaagaag ctgggcctgt ccttctocat cgaggcgatc ctaaagaggc ctgccaggag 1080 gagtgatatg gacagaccag aagggccagg tgaagagggc cccggagaag ctgcggcctc 1140 aggctctggg ctagaaaagc ctccaaagga ccagccccag gaaggaagga agagcaagcg 1200 gagggttcgt accaccttca ccactgagca gctgcatgag ctggagaaga tcttccactt 1260 tacccactac ccagacgttc acatccgcag ccagctggca gccaggatca acctcccaga 1320 agctcgggtg cagatctggt tccagaatoa gcgagccaag tggcggaagc aggagaagat 1380 tggcaacctg ggggctccac agcagctgag tgaagccagt gtggtcctgc ccacaaatct 1440 ggatgtggct gggcccacgt ggacatccac tgctctgcgc aggctggctc ctcccacgag 1500 ctgttgtcca tcggctoaag atcagctggc ctctgcctgg ttccctgcct ggatcaocct 1560 cctcccagcg caoccatggg aaacacagcc tgtcccaggt cttcccatcc atcaaacttg 1620 catccctgtg ctatgcatcc ttccacctcc acaccccaaa tggggcagca tctgtgctae 1680 ttcaacatag agattggaca tgctctoocc aaatgagcoa ctttcctctc oaggtgaagg 1740 caggtagcag atgtgccctg ggcctctggg gaaatcgatc tcacaatcca aaaatggccc 1800 acagoccagg aagctaccct gaacatgcca gttggaaggc tgcaccagac tcaaaagcaa 1860 actaaacaat aaaggacagc tctcttctct cctggctaaa gctgctctcc tggttcagaa 1920 gacaggctgg atgagatctc aggccgagct otgaaatagg gaggtaatcc tccagcacct 1980 gtgtttcctc taacttgctg tgtgacctcc agccggtcac toaocctctc tggacctcat 2040 ctgtaagagg agccagctgg ataagatgat ttctgaagac gcttccatgg tgggcactga 2100 ggcacagagg aggccaagga gaggttgttt gttcatgcat gcattcatcc gtgacacatg 2160 agtacctaot gaggactcoa taaacagaac gggatacaga gataaacaat ttgggttctg 2220 tccacgtttg toaaaaggtg gtgotggccc acotctgaaa gcagaacaot tgctcaacaa 2280 ccttgctgtt ggccoaagtc taaoacatto tttatgactg tgagcatctc agagtgagag 2340 aaaaatgtag aaagtttttt aaattctaaa caggatttag tgtctttagt tatcttgctg 2400 gatgggaaag ggatgttgtc atttctggca caaatgaaaa gtaggacgga aagctccttt 2460 cattcagttt atctttccag gatatatgaa aagggaccag ctggaagact agcctcactc 2520 tgtcctcgaa agcctgagct ttcattcaac tccctatttc catgoaaaga cgctgggcaa 2580 accacatgtt ctgtctgagc ctcagttttc ctatccataa aatgaaggta gccaggcctg 2640 cctcaaagag cattcaggag gctctgagag gacatgagag tattttgcaa agtgagggca 2700 aggcccagtg tggagtgata ttgttattec aagattccac tgcaaaagtg gctgctttgg 2760 atgccagccc aggatgagta gttcctgttc tcagggaggt catccgctga gcatcccttc 2820 tgcacagatg tctctgattc ttgtccttgc aggtggagga cagggoctgc tcccctaagc 2880 tgggaagcct ggaatgacct cttgcacaag cctaaattcc aggaatcttc cccaaatccc 2940 agatootctg caatctacct gcacccctga ccoacccagg agttggaccg ggagttggga 3000 agcctaggtc ttagtcctac actccttcta atttgctgtg taaccttacc attaatctct 3060 ctgggtctca gttttetcat ctgtattgga ggtagcagtg ctagctctgc cttcaggcat 3120 gcaatatgcc agaactacag acaacagccc acaggatgca aaagtgcttt gccatottaa 3180 aaatgccaga tcactcagag cctatgaatg tggatatcaa caccaggtct ctagcaccgc 3240 tggatgaaag gagaaggcta gaggotgagg gaggaaagag cagttaacaa acaaaggcag 3300 tagctcatca cttgggtagc aggtacccat tttaggaccc tacactcaaa tgtgcaaaat 3360 aaaatttcta tcattttgct ataaaaaaaa aaaaaaaaaa aaa 3403

<210> 75 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 75 cccggatcgc catcagtgtc atcgagttca aaccctgagc ccttcattca cctctgtgag 60

<210> 76 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 76 tgcccttgct ctgtgtcatc tcagtcattt gacttagaaa gtgcccttca aaaggaccct 60

<210> 77 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 77 ggagggaggg ctaattatat attttgttgt tcctctatac tttgttctgt tgtctgcgcc 60

<210> 78 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 78 cagtttggat tgtataataa cgccaagccc agttgtagtc gtttgagtgc agtaatgaaa 60

<210> 79 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 79 aaatcagagt aaccctttct gtattgagtg cagtgttttt tactcttttc tcatgcacat 60

<210> 80 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 80 tgcctggcac aaagaaggaa gaatataaat gatagttcga ctcgtctgtg gaagaactta 60

<210>81 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 81 agtcttttgc ttttggcaaa actctactta atccaatggg tttttccctg tacagtagat 60 <210> 82

<211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 82 ggttactgtg ggtggaatag tggaggcctt caactgatta gacaaggccc gcccacatct 60

<210> 83 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 83 taaaatgcac tgccctactg ttggtatgac taccgttacc tactgttgtc attgttatta 60

<210> 84 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 84 ttctcttttg ggggcaaaca ctatgtcctt ttctttttct agatacagtt aattcctgga 60

<210> 85 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 85 aagacccaca ccctgtagca ataccaagtg ctattacata atcaatggac gatttatact 60

<210> 86 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 86 agtgttgcaa gtttccttta aaaccaacaa agcccacaag tcctgaattt cccattctta 60

<210> 87 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 87 gtcactgtca tagcagctgt gatttcacaa ggaagggtgc tgcaggggga cctggttgat 60

<210> 88 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 88 tttcatccag tgttatgcac tttccacagt tggtgttagt atagccagag ggtttcatta 60

<210> 89 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 89 gggaagtagg gattattcgt ttaaattcaa tcgcgagcac caagtcggac tggccgggga 60

<210> 90 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 90 gggaccaggc cctgggacag ccatgtggct ccaaatgact aaatgtcagc tcaaaaacca 60

<210> 91 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 91 tccgtttatg gaggcaattc catatccttt cttgaacgca cattcagctt accccagaga 60

<210> 92 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 92 agagttaagc cacttcctgg gtctccttct tatgactgtc tatgggtgca ttgccttctg 60

<210> 93 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 93 gtggcctgag taatgcatta tgggtggttt accatttctt gaggtaaaag catcacatga 60

<210> 94 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 94 acacatgcat gtgtctgtgt atgtgtgaat gtgagagaga cacagccctc ctttcagaag 60

<210> 95 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 95 tctgtaactg cacaaccctg gggtttgctg cagagctatt tctttccatg taaagtagtg 60

<210> 96 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 96 aaacactctt tccgactcca gaggagaagc tggcagctct ctgtaagaaa tatgctgatc 60

<210> 97 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 97 gcttcctcta tcgcccaatg caaaatcgat gaaatgggga gttctctggg ccaggccaca 60

<210> 98 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 98 gtagaatcct ctgttcataa tgaacaagat gaaccaatgt ggattagaaa gaagtccgag 60

<210> 99 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 99 ctgttttaaa actgaatggc acgaaattgt tttcctcaac tcggagattc ctgtatggag 60

<210> 100 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400>100 aataaatagt agctctgctg atgatgacgt tgataaccaa actgttctgt ggtcttaagt 60

<210> 101 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 101 caaacagccc ggtcttgatg caggagagtc tggaaaagga agaaaatggt ttcagtttca 60

<210> 102 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 102 aacatggacc atccaaattt atggccgtat caaatggtag ctgaaaaaac tatatttgag 60

<210> 103 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 103 ttgtaatcat gccaattcca gatcaataac tgcatgtctg ttctttggta gaaatagctt 60

<210> 104 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 104 aaagattatt aacccaaatc acctttcttg cttactccag atgcctcagc ctctgatata 60 <210> 105

<211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400>105 gacttccttt aggatctcag gcttctgcag ttctcatgac tcctactttt catcctagtc 60

<210> 106 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400>106 ctgtatattt tgcaatagtt acctcaaggc ctactgacca aattgttgtg ttgagatgat 60

<210> 107 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400>107 tgttcaaaca gactttaacc tctgcatcat acttaaccct gcgacatgcg tacagtatgc 60

<210> 108 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400>108 tgagtcatat acatttactg accactgttg cttgttgctc actgtgctgc ttttccatga 60

<210> 109 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400>109 ctgaaatgtg gatgtgattg cctcaataaa gctcgtcccc attgcttaag ccttcaaaaa 60

<210> 110 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 110 atcaagaaaa cctaatcttc tgactcccag gccaggatgt tttatttctc acatcatgtc 60

<210> 111 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 111 ttcatttcca aacatcatct ttaagactcc aaggattttt ccaggcacag tggctcatac 60

<210> 112 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 112 agttagaaat agaatctgaa tttctaaagg gagattctgg cttgggaagt acatgtagga 60

<210> 113 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 113 caattttctt tttactcccc ctcttaaggg ggccttggaa tctatagtat agaatgaact 60

<210> 114 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 114 gggtggagtt tcagtgagaa taaacgtgtc tgcctttgtg tgtgtgtata tatacagaga 60

<210> 115 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 115 ctcgctcatt ttttaccatg ttttccagtc tgtttaactt ctgcagtgcc ttcactacac 60

<210> 116 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 116 ctttgggccg agcactgaat gtcttgtact ttaaaaaaat gtttctgaga cctctttcta 60

<210> 117 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 117 ctggaccctt ggagcagtgt tgtgtgaact tgcctagaac tctgccttct ccgttgtcaa 60

<210> 118 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 118 ccacctcctt cgacctccac tgcgccccac ctccctgcct gtgtgtgtta tttcaaagga 60

<210> 119 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 119 tctggctggt ggcctgcgcg agggtgcagt cttacttaaa agactttcag ttaattctca 60

<210> 120 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 120 agatgctgtc ggcaccatgt ttatttattt ccagtggtca tgctcagcct tgctgctctg 60

<210> 121 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 121 tccttcctct tcggtgaatg caggttattt aaactttggg aaatgtactt ttagtctgtc 60

<210> 122 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 122 gtcctgtccc tgtctgggag ttgtgttatt taaagatatt ctgtatgttg tatcttttgc 60

<210> 123 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 123 attatatttc aggtgtcctg aacaggtcac tagactctac attgggcagc ctttaaatat 60

<210> 124 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 124 aggaatggta ctaccgttcc agattttctg taattgcttc tgcaaagtaa taggcttctt 60

<210> 125 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400>125 ctgtacccaa aggatgccag aatactagta tttttattta tcgtaaacat ccacgagtgc 60

<210> 126 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 126 attgcccccc taaccaatca tgcaaacttt tccccccctg gggtaattca ccagttaaaa 60

<210> 127 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400>127 cccacagtat ttaatgccct gtcagtccct tctagtctga ctcaatggta acttgctgta 60 <210> 128

<211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 128 aaaaccaact ctctactaca caggcctgat aactctgtac gaggcttctc taacccctag 60

<210> 129 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 129 ctcagactgg gctccacact cttgggcttc agtctgccca tctgctgaat ggagacagca 60

<210> 130 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 130 cctaatgggg attcctctgg ttgttcactg ccaaaactgt ggcattttca ttacaggaga 60

<210> 131 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 131 cactcacaat tgttgactaa aatgctgcct ttaaaacata ggaaagtaga atggttgagt 60

<210> 132 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 132 ctttgaaggg ctgctgcaca ttgttgaatc catcgacctt tagctgcaat gggatctcta 60

<210> 133 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 133 tgcctcatcg atattatagg ggtccatcac aacccaactg tgtggccgga tcctgagtct 60

<210> 134 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 134 aaaacagaca aaagcctttg ccttcatgaa gcatacattc attcaggggt agacacacaa 60

<210> 135 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400>135 taacaaacaa aggcagtagc tcatcacttg ggtagcaggt acccatttta ggaccctaca 60

<210> 136 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 136 atatcagaag tgccaataat cgtcataggc ttctgcacgt tggatcaact aatgttgttt 60

<210> 137 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400>137 atcatagccc aaccatgtga gaagaaggag aaggcccccc tttcttcatt aatctgaaaa 60

<210> 138 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 138 gcagaccatt ctatcatacc tggcagggct tctgttttat tttgtaggct ggatgctacc 60

<210> 139 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 139 actacaagcc tcttgttttt caccaaaacc ctacatctca ggcttactaa tttttgtgat 60

<210> 140 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400>140 gccatgcata catgctgcgc atgttttctt cattcgtatg ttagtaaagt tttggttatt 60

<210> 141 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 141 cacctattta ttttacctct ttcccaaacc tggagcattt atgcctaggc ttgtcaagaa 60

<210> 142 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 142 gtggacatag ccactaacca actagttacc tttggactgc aacaaaaaat gtgaaaatga 60

<210> 143 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 143 acttgtaaac ctcttttgca ctttgaaaaa gaatccagcg ggatgctcga gcacctgtaa 60

<210> 144 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 144 aattctctat aaacggttca ccagcaaacc accaatacat tccattgttt gcctagagag 60

<210> 145 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400>145 aatggcccat gcatgctgtt tgcagcagtc aattgagttg aattagaatt ccaaccatac 60

<210> 146 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400>146 gagctcagta cttgccctgt gaaaatccca gaagcccccg ctgtcaatgt tccccatcca 60

<210> 147 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400>147 atgaagcgga attaggctcc cgagctaagg gactcgccta gggtctcaca gtgagtagga 60

<210> 148 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400>148 agtggctata tcaacatcag ggctagcaca tctttctcta ttatccttct attggaattc 60 <210> 149 <211> 1108

<212> DNA <213> Homo sapiens <400> 149 gagtgagtga gagggcagag gaaatactca atctgtgcca ctcactgoct tgagcctgct 60 tcctcactcc aggactgcca gaggctcact cccttgagcc tgcttcctca ctccaggact 120 gccagaggaa gcaatcacca aaatgaagac tgctttaatt ttgctcagca ttttgggaat 180 ggcctgtgct ttctcaatga aaaatttgca tcgaagagtc aaaatagagg attctgaaga 240 aaatggggtc tttaagtaca ggccacgata ttatctttac aagcatgcct aottttatoc 300 tcatttaaaa cgatttccag ttcagggcag tagtgactca tccgaagaaa atggagatga 360 cagttcagaa gaggaggagg aagaagagga gacttcaaat gaaggagaaa acaatgaaga 420 atcgaatgaa gatgaagact ctgaggctga gaataooaca ctttctgcta caacactggg 480 ctatggagag gacgccacgc ctggcacagg gtatacaggg ttagctgcaa tocagcttcc 540 caagaaggct ggggatataa caaacaaagc tacaaaagag aaggaaagtg atgaagaaga 600 agaggaggaa gaggaaggaa atgaaaaoga agaaagcgaa gcagaagtgg atgaaaacga 660 acaaggcata aacggcacca gtaccaacag cacagaggca gaaaacggca acggcagcag 720 cggaggagac aatggagaag aaggggaaga agaaagtgtc actggagcca atgcagaagg 780 caccacagag accggagggc agggoaaggg cacctcgaag acaacaacct ctccaaatgg 840 tgggtttgaa cctacaaccc caccacaagt ctatagaacc acttccccac cttttgggaa 900 åaccaccacc gttgaatacg agggggagta cgaatacacg ggcgtcaatg aatacgacaa 960 tggatatgaa atctatgaaa gtgagaacgg ggaacctcgt ggggacaatt accgagccta 1020 tgaagatgag tacagctact ttaaaggaca aggctacgat ggctatgatg gtcagaatta 1080 ctaccaccac cagtgaagct ccagcctg 1108 <210> 150 <211 >4767

<212> DNA <213> Homo sapiens <400> 150 gcctcccgcc gcctcccgcg cggccatgga ctgagcgccg ccggccaggc cgcggggatg 60 gggccgccgc tcccgctgct gctgctgcta ctgctgctgc tgccgccacg cgtcctgcct 120 gccgcccctt cgtccgtccc ccgcggccgg cagctcccgg ggcgtctggg ctgcctgctc 1 SO gaggagggcc tctgcggagc gtccgaggcc tgtgtgaacg atggagtgtt tggaaggtgc 240 cagaaggttc cggcaatgga cttttaccgc tacgaggtgt cgcccgtggc cctgcagcgc 300 ctgcgcgtgg cgttgcagaa gctttccggc acaggtttca cgtggcagga tgactatact 360 cagtatgtga tggaccagga acttgcagac ctcccgaaaa cctacctgag gcgtcctgaa 420 gcatccagcc cagccaggcc ctcaaaacac agcgttggca gcgagaggag gtacagtcgg 480 gagggoggtg ctgccctggc caacgccctc cgacgccacc tgcccttcct ggaggccctg 540 tcccaggccc cagcctcaga cgtgctcgcc aggacccata cggcgoagga cagacccccc 600 gctgagggtg atgaccgctt ctccgagagc atcctgacct atgtggccca cacgtctgcg 660 ctgacctacc ctcccgggcc ccggaoccag ctccgcgagg acctcctgcc gcggaccctc 720 ggccagctcc agccagatga gcteagccct aaggtggaca gtggtgtgga cagaoaccat 780 ctgatggcgg ccctcagtgc ctatgctgcc cagaggcccc cagctocccc cggggagggc 840 agoctggagc cacagtacct tctgcgtgca ccctcaagaa tgccoaggcc tttgctggca 900 ccagccgccc cccagaagtg gccttcacct ctgggagatt ocgaagaccc ctccagcaca 960 ggcgatggag cacggattca taccctcctg aaggacctgc agaggcagcc ggctgaggtg 1020 aggggcctga gtggcctgga gctggacggc atggctgagc tgatggctgg cctgatgcaa 1080 ggcgtggacc atggagtagc tcgaggoagc cctgggagag cggccctggg agagtctgga 1140 gaacaggcgg atggccccaa ggccaccctc cgtggagaca gctttccaga tgacggagtg 1200 caggaogacg atgatagaot ttaccaagag gtccatcgtc tgagtgccac actcgggggc 1260 ctcctgcagg accacgggtc tcgactctta cctggagccc tcccctttgc aaggcccctc 1320 gacatggaga ggaagaagtc cgagcaccct gagtcttccc tgtcttcaga agaggagact 1380 gccggagtgg agaacgtcaa gagocagacg tattccaaag atctgctggg gcagcagccg 1440 cattcggagc ccggggccgc tgcgtttggg gagctccaaa accagatgcc tgggccctcg 1500 aaggaggagc agagccttcc agcgggtgct oaggaggcco tcagcgacgg cctgcaattg 1560 gaggtccagc cttccgagga agaggcgcgg ggctacatog tgacagacag agaccccctg 1620 cgccccgagg aaggaaggcg gctggtggag gacgtcgccc gcctcctgca ggtgccoagc 1680 agtgcgttcg ctgacgtgga ggttctcgga ccagoagtga ccttcaaagt gagogccaat 1740 gtccaaaacg tgaccactga ggatgtggag aaggccacag ttgacaacaa agaoaaactg 1800 gaggaaaoct ctggactgaa aattcttcaa aocggagtcg ggtcgaaaag oaaactcaag 1860 ttcctgcctc ctcaggcgga gcaagaagac tccaccaagt tcatcgcgct caccctggtc 1920 tccctcgcct gcatcctggg cgtcctcctg gcctctggcc tcatctactg cctccgccat 1980 agctctoagc acaggctgaa ggagaagctc tcgggactag ggggcgaccc aggtgcagat 2040 gccactgccg cctaccagga gctgtgccgc cagcgtatgg ccacgcggcc accagaccga 2100 cctgagggcc cgcacacgtc acgcatcagc agcgtctcat cccagttcag cgacgggccg 2160 atccccagcc octccgcacg cagcagcgcc tcatcctggt ccgaggagoo tgtgcagtcc 2220 aacatggaca tctccaccgg ccacatgatc ctgtcctaca tggaggacca cctgaagaao 2280 aagaaccggc tggagaagga gtgggaagcg ctgtgcgcct accaggogga gcccaacagc 2340 tcgttcgtgg oooagaggga ggagaacgtg cccaagaacc gctccctggc tgtgctgacc 2400 tatgaccact cccgggtcct gctgaaggcg gagaacagcc acagccactc agactacatc 2460 aacgctagcc ccatcatgga tcacgacccg aggaaccccg cgtacatcgc cacccaggga 2520 ccgctgcccg ccaccgtggc tgacttttgg cagatggtgt gggagagcgg ctgcgtggtg 2580 atcgtcatgc tgacacccct cgcggagaac ggcgtccggc agtgctacca ctactggccg 2640 gatgaaggct ccaatctcta ccacatctat gaggtgaacc tggtctccga gcacatctgg 2700 tgtgaggact tcctggtgag gagcttctat ctgaagaacc tgcagaccaa cgagacgcgc 2760 accgtgacgc agttccactt cctgagttgg tatgaccgag gagtcccttc ctcctcaagg 2820 tccctcctgg acttccgcag aaaagtaaac aagtgctaca ggggccgttc ttgtccaata 2880 attgttcatt gcagtgacgg tgcaggccgg agcggcacct acgtcctgat cgacatggtt 2940 ctcaacaaga tggccaaagg tgctaaagag attgatatcg cagcgaccct ggagcacttg 3000 agggaccaga gacccggcat ggtccagacg aaggagcagt ttgagttcgc gctgacagcc 3060 gtggctgagg aggtgaacgc catcctcaag gcccttoccc agtgagcggc agcctoaggg 3120 gcctcagggg agcccccacc ccacggatgt tgtcaggaat catgatctga ctttaattgt 3180 gtgtcttcta ttataactgc atagtaatag ggcccttagc tctcccgtag tcagcgcagt 3240 ttagcagtta aaagtgtatt tttgtttaat caaacaataa taaagagaga tttgtggaaa 3300 aatccagtta cgggtggagg ggaatcggtt catcaatttt cacttgctta aaaaaaatac 3360 tttttcttaa agcacccgtt caccttcttg gttgaagttg tgttaacaat gcagtagcca 3420 gcaogttcga ggcggtttcc aggaagagtg tgcttgtcat otgccacttt ogggagggtg 3480 gatccactgt gcaggagtgg ccggggaagc tggcagcact cagtgaggcc gcccggcaca 3540 caaggcacgt ttggcatttc tctttgagag agtttatcat tgggagaagc cgcggggaca 3600 gaactgaacg tcctgcagct tcggggcaag tgagacaatc acagotcctc gctgcgtctc 3660 catcaacact gcgccgggta ccatggacgg ccccgtoagc cacacctgtc agcccaagca 3720 gagtgattca ggggctcocc gggggcagac acctgtgcac cccatgagta gtgcccaott 3780 gaggctggca ctcccctgac ctcacctttg caaagttaca gatgcacccc aacattgaga 3840 tgtgttttta atgttaaaat attgatttct acgttatgaa aacagatgcc cccgtgaatg 3900 cttaoctgtg agataaccac aaccaggaag aacaaatctg ggcattgagc aagctatgag 3960 ggtccccggg agcacacgaa ccctgccagg cccccgctgg ctcctccagg cacgtcccgg 4020 acctgtgggg ccccagagag gggacatttc cctcctggga gagaaggaga tcagggcaac 4080 tcggagaggg ctgcgagcat ttccctcccg ggagaggaga tcagggcgac ctgcacgcao 4140 tgcgtagagc ctggaaggga agtgagaaac cagccgaccg gocctgcccc tcttcccggg 4200 atcacttaat gaaccacgtg ttttgacatc atgtaaacct aagcacgtag agatgattcg 4260 gatttgacaa aataacattt gagtatccga ttcgccatca ccccctaccc cagaaatagg 4320 acaattcact tcattgacca ggatgatcac atggaaggcg gogcagaggc agctgtgtgg 4380 gctgcagatt tcctgtgtgg ggttcagcgt agaaaacgca cctccatccc gcccttccca 4440 cagcattcct ccatcttaga tagatggtac tctccaaagg ccctaccaga gggaacacgg 4500 cctactgagc ggacagaatg atgccaaaat attgcttatg tctctacatg gtattgtaat 4560 gaatatctgc tttaatatag ctatoattto ttttccaaaa ttacttctct ctatctggaa 4620 tttaattaat cgaaatgaat ttatctgaat ataggaagca tatgcctact tgtaatttct 4680 aactccttat gtttgaagag aaacctccgg tgtgagatat acaaatatat ttaattgtgt 4740 catattaaac ttctgattca aaaaaaa 4767 <210> 151 <211> 1148

<212> DNA <213> Homo sapiens <400> 151 ggcacgaggc caogagctgt tgtgcatcca gaggtggaat tggggcccgg cattccctcc 60 tcgtcccggg ctggcccttg cccccaccct gcaactcctg gttgagatgg gctcagccaa 120 gagcgtccca gtcacaccag cgcggcotcc gccgcacaac aagcatctgg ctcgagtggc 180 ggacocccgt tcacctagtg ctggcatcct gcgoactcoc atccaggtgg agagctotcc 240 aoagccaggo ctaccagcag gggagcaact ggagggtott aaacatgccc aggactcaga 300 tccccgctct cctactcttg gtattgcacg gacacctatg aagaccagca gtggagaccc 360 cccaagccca ctggtgaaac agctgagtga agtatttgaa actgaagact ctaaatcaaa 420 tottccccca gagcctgtto tgococcaga ggcaccttta tcttctgaat tggacttgcc 480 tctgggtacc cagttatctg ttgaggaaca gatgccacct tggaaccaga ctgagttccc 540 ctccaaacag gtgttttcoa aggaggaagc aagacagccc acagaaaccc ctgtggccag 600 ocagagctcc gacaagccot caagggaccc tgagactccc agatcttcag gttctatgcg 660 caatagatgg aaaccaaaca gcagcaaggt actagggaga tcccccctca ccatcctgca 720 ggatgacaac teccctggca ccctgacact acgacagggt aagcggcctt cacccctaag 780 tgaaaatgtt agtgaactaa aggaaggagc cattcttgga actggacgac ttctgaaaac 840 tggaggacga gcatgggagc aaggccagga ccatgacaag gaaaatcagc actttccctt 900 ggtggagagc taggccctgc atggccccag caatgcagtc acccagggcc tggtgatatc 960 tgtgtcctct caccccttct ttcccaggga tactgaggaa iggcttgttt tcttagactc 1020 ctcctcagct aocaaactgg gactcacagc tttattgggc tttctttgtg tcttgtgtgt 1080 ttcttttata ttaaaggaag taattttaaa tgttacttta aaaaggtaaa aaaaaaaaaa 1140 aaaaaaaa 1148 <210> 152 <211> 539

<212> DNA <213> Homo sapiens <400> 152 gcattcgtag taaaggtgcc caagaaatta ttttggccat ttattgtttt gtccttttct 60 ttaaagaact gttttttttt cttttgttta cttttagacc aaagattggg ttctagaaaa 120 tgcacttggt atactaagta ttaaaacaaa caaaaaggaa agttgtttca gttggcaaca 180 ctgcccattc aattgaatca gaaggggaca aaattaacga ttgccttcag tttgtgttgt 240 gtatattttg atgtatgtgg tcactaacag gtcactttta ttttttetaa atgtagtgaa 300 atgttaatac ctattgtact tataggtaaa ccttgcaaat atgtaacctg tgttgcgcaa 360 atgccgcata aatttgagtg attgttaatg ttgtcttaaa atttcttgat tgtgatactg 420 tggtcatatg cccgtgtttg tcacttacaa aaatgtttac tatgaacaca oagaaataaa 480 aaataggcta aattcatata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 539 <210> 153 <211> 1673

<212> DNA <213> Homo sapiens <400> 153 gaggcagtaa ggacttggac tcctctgtcc agcttttaac aatctaagtt acggttaccc 60 tottctgggt cacgctagaa tcagatctgc tctccagcat cttctgtttc ctggcaagtg 120 tttcctgcta ctttggattg gccacgatgg gctggagctg ccttgtgaca ggagcaggag 180 ggcttctggg tcagaggatc gtccgcctgt tggtggaaga gaaggaactg aaggagatca 240 gggccttgga caaggccttc agaccagaat tgagagagga attttctaag ctccagaaca 300 ggaccaagct gactgtactt gaaggagaca ttctggatga gccattcctg aaaagagcct 360 gccaggacgt ctcggtcgtc atccacaccg cctgtatcat tgatgtcttt ggtgtcaotc 420 acagagagtc catcatgaat gtcaatgtga aaggtaccca gctactgttg gaggcctgtg 480 tccaagccag tgtgccagtc ttcatctaca ccagtagcat agaggtagcc gggcocaact 540 cctacaagga aatcatccag aacggccacg aagaagagcc tctggaaaac acatggccca 600 otccatacco gtacagcaaa aagcttgctg agaaggctgt gctggcggct aatgggtgga 660 atctaaaaaa tggtgatacc ttgtacactt gtgcgttaag acccacatat atctatgggg 720 aaggaggccc attcctttct gccagtataa atgaggccct gaacaacaat gggatcctgt 780 caagtgttgg aaagttotct acagtcaaco cagtctatgt tggcaacgtg goctgggccc 840 aoattctggc cttgagggct otgcgggaco ooaagaaggo ccoaagtgto ogaggtoaat 900 tctattacat ctcagatgac acgcctcacc aaagotatga taaccttaat tacatootga 960 gcaaagagtt tggoctocgc cttgattcca gatggagcct tcctttaacc ctgatgtaot 1020 ggattggctt cctgctggaa gtagtgagct tcctactcag cccaatttac tcctatcaac 1080 ccoccttoaa ocgccacaca gtcacattat caaatagtgt gttcaccttc tcttacaaga 1140 aggctcagcg agatctggcg tataagccac tctacagctg ggaggaagcc aagcagaaaa 1200 ccgtggagtg ggttggttcc cttgtggacc ggcacaagga gaccctgaag tccaagactc 1260 agtgatttaa ggatgaoaga gatgtgcatg tgggtattgt taggaaatgt oatcaaactc 1320 cacccacctg gcttcataca gaaggcaaca ggggcacaag cccaggtcct gctgcctctc 1380 tttcacaeaa tgcecaactt actgtcttct teatgtcatc aaaatctgca cagtcactgg 1440 cccaaccaga actttctgtc ctaatcatac accagaagao aaacaatatg atttgctgtt 1500 accaaatctc agtggctgat tctgaacaat tgtggtotot cttaacttga ggttctcttt 1560 tgactaatag agctccattt cccctcttaa atgagaaagc atttcttttc tctttaatct 1620 cctattcctt cacacagttc aacataaaga gcaataaatg ttttaatgct taa 1673 <210> 154 <211 > 518

<212> DNA <213> Homo sapiens <400> 154 aaattttgac cccatataaa gaaatgtgtt atgtatgttg tgcctcctta gagacataaa 60 tttagtgtca aaacatggga gatggcttac tcagaagoat actocactta acataccatg 120 gcctgagcta agtaccatgt cctgtttgtg tcttattttt aaatattttc tttgtecaca 180 tgggccgttg accttagagt taaggcggtt gcttttttga agaaatcacc aaagtttctg 240 ggaaactatg ttcaaggttg aaatggagag tagatttaat tttatttgtc ttgtagggaa 300 gaaatcttcc tttgaaccgc ttttcttgct ttttcccttt ttcccaaact aggttacagg 360 ttcttatctg caaggttcaa gttgcttaga cattgttttc oagtattctg cagggccagt 420 cagttgtaca gaagttggaa tattctgttc cagaattaaa gaagttttta gattatgaaa 480 tattatgata ataaagctat atttctgaaa aaaaaaaa 518 <210> 155 <211 >2833

<212> DNA <213> Homo sapiens <400> 155 gaaggagctc tcttcttgct tggcagctgg accaagggag ccagtcttgg gogctggagg 60 gcctgtcctg accatggtcc ctgcctggct gtggctgctt tgtgtotccg tcccccaggc 120 tctccccaag gcccagcctg cagagctgtc tgtggaagtt ccagaaaact atggtggaaa 180 tttcccttta tacctgacca agttgccgct gccccgtgag ggggctgaag gccagatcgt 240 gctgtcaggg gactcaggca aggcaactga gggcccattt gctatggatc cagattctgg 300 cttcctgctg gtgaocaggg occtggaccg agaggagcag gcagagtacc agctaoaggt 360 caccotggag atgcaggatg gacatgtctt gtggggtcca cagcctgtgc ttgtgcacgt 420 gaaggatgag aatgaccagg tgccccattt ctctcaagcc atctacagag ctcggctgag 480 ecggggtacc aggoctggca tccccttcct cttccttgag gcttcagacc gggatgagoc 540 aggcacagcc aactoggatc ttcgattcca catoctgagc caggctccag occagccttc 600 cccagacatg ttccagctgg agcctcggct gggggctctg gccctcagcc ccaaggggag 660 caccagcctt gaccacgccc tggagaggac ctaccagctg ttggtacagg tcaaggacat 720 gggtgaccag gcctcaggcc accaggccac tgccaccgtg gaagtctcca tcatagagag 780 cacctgggtg tccctagagc ctatccacct ggcagagaat ctcaaagtcc tatacccgca 840 ccacatggcc caggtacact ggagtggggg tgatgtgcac tatcacctgg agagccatcc 900 cccgggaccc tttgaagtga atgcagaggg aaacctotac gtgaccagag agctggacag 960 agaagcocag gctgagtacc tgctccaggt gcgggctcag aattcccatg gcgaggaota 1020 tgcggcocct otggagctgc acgtgctggt gatggatgag aatgacaacg tgcctatctg 1080 ccctccccgt gaccccacag tcagcatccc tgagctcagt ccaccaggta ctgaagtgac 1140 tagactgtca gcagaggatg cagatgcccc cggctccccc aattcccacg ttgtgtatoa 1200 gctcctgagc cctgagcctg aggatggggt agaggggaga gccttccagg tggaccccac 1260 ttcaggcagt gtgacgctgg gggtgctccc actccgagca ggccagaaca toctgottct 1320 ggtgctggcc atggacctgg caggcgcaga gggtggcttc agcagcacgt gtgaagtcga 1380 agtcgcagto acagatatca atgatcacgc ccctgagttc atcacttccc agattgggcc 1440 tataagcctc cctgaggatg tggagcccgg gactctggtg gccatgctaa cagccattga 1500 tgctgacctc gagcccgcct tccgcctcat ggattttgcc attgagaggg gagacacaga 1560 agggactttt ggoctggatt gggagccaga ctctgggcat gttagactca gactctgcaa 1620 gaacctcagt tatgaggcag ctccaagtca tgaggtggtg gtggtggtgc agagtgtggc 1680 gaagctggtg gggccaggcc caggccctgg agccaccgcc acggtgactg tgctagtgga 1740 gagagtgatg ccacccccca agttggacca ggagagctac gaggccagtg tccccatcag 1800 tgccccagcc ggctctttcc tgctgaccat ccagccctcc gaccccatca gccgaaccct 1860 caggttctcc ctagtcaatg actcagaggg ctggctctgc attgagaaat tctccgggga 1920 ggtgcacacc gcccagtccc tgcagggcgc ccagcctggg gacacctaca cggtgcttgt 1980 ggaggccoag gatacagatg agccgagact gagcgcttct gcacccctgg tgatccactt 2040 cctaaaggcc cctcctgccc cagccotgac tcttgcocct gtgccctccc aatacctctg 2100 cacaccccgc caagaccatg gcttgatcgt gagtggaccc agcaaggacc ccgatctggc 2160 cagtgggcac ggtccctaca gcttcacoct tggtcccaac cccacggtgc aacgggattg 2220 gcgoctccag actctcaatg gttcccatgo ctacctcacc ttggccctgc attgggtgga 2280 gccacgtgaa cacataatcc ccgtggtggt cagcoacaat gcccagatgt ggcagctoot 2340 ggttcgagtg atcgtgtgtc gctgcaacgt ggaggggcag tgcatgcgca aggtgggccg 2400 catgaagggc atgoccacga agctgtcggc agtgggcatc cttgtaggca ccctggtagc 2460 aataggaatc ttcctcatcc tcattttcac ccactggacc atgtcaagga agaaggaccc 2520 ggatcaacca gcagacagcg tgcccctgaa ggcgactgtc tgaatggccc aggcagctct 2580 agctgggagc ttggcctctg gctccatctg agtcccctgg gagagagccc agcacccaag 2640 atccagcagg ggaoaggaca gagtagaagc ccctccatct gccctggggt ggaggcacca 2700 tcaccatcac caggcatgtc tgcagagcct ggacaccaac tttatggact goccatggga 2760 gtgctccaaa tgtcagggtg tttgcccaat aataaagcoo oagagaaotg ggctgggccc 2820 tatgggattg gta 2833 <210> 156 <211> 592

<212> DNA <213> Homo sapiens <400> 156 tctttaccta tgtgaagcga ggtgacgtga tacgtcactg gcgccgtctt ataatttaga 60 tgtaaaaatc tttagaaaca aataaaactc tctatatatg tgtatgtctg tgtacaaaaa 120 aatgacagag ctgatggcca gtgtatacag agcgtggcec gcggtgtaca ataoccatat 180 aaggtacatt gtgcaggagg ggaattgctg gctgctttta cttcctgacc aagactgaaa 240 aattatttac tgaaatctgt aaaccttttt atgaaacttt taagcaccag gctgtttact 300 tacacaattt aggtctgcca gaaaattcta tctgtgatag atctgtaaag agggtcaggg 360 gttagagttt actatttttg aagtttacat tgttacatat gaaatggaaa cattattttg 420 aaacgttgtc ataacccaat ggtgcattct gtaaccatgg agtcttctgt ttcotggggg 480 aaaggggcat tcatgacctg aactttttag caaattatta ttctcagttt ocattacctg 540 tttggccaaa cagattaata aaatatttga aaaagaagca ataaaaaaaa aa 592 <210> 157 <211> 818

<212> DNA <213> Homo sapiens <220> <221 > misc_feature <222> (60)..(60) <223> a or g or c or t/u <220> <221 > misc_feature <222> (80)..(80) <223> a or g or c or t/u <220> <221 > misc_feature <222> (114)..(114) <223> a or g or c or t/u <220> <221 > misc_feature <222> (121)..(121) <223> a or g or c or t/u <400> 157 ctgagaaagt ccggtcccta taaggggaca tcagtgcgag acotgotccg tgctgtgagn 60 acaagaggca ccatacaagn aagctcccag ttgaggtgcg acaggcactc gccnaagtcc 120 ntgatggctt cgtccagtac tcacaaaacg gctccccccg gotggtcctt cacacgcacc 180 gagccatgag gagctggcgc ctctgagagc ctcttcctgc cctactaccc gccagactca 240 gaggccagga ggccatgccc tggggccaca gggaggtgag gtgggctgga tgccacaoag 300 atggtctocg tgctggctca ctgaagagct gagcctgtgg ctggcctcag aatcaggctg 360 ggtgcagtgg ctoaoacctg taatcocagc attttgggag gctgagtgag aggatcactt 420 gagctoagga gttcgagacc agcctggcca acatggcaac accccatttc tacaaaaaat 480 ttgtaaaatt agccaggcat ggtggcgcac gcctgtagtc ccagctgctt gggaggctga 540 ggtgggagaa tcacttgagc ccaggagttc gaggctgcag tgagccagga tcatgccact 600 gcactccagc ctggtccaca gagagacact gtcaccccct ttcccccaca agactggcag 660 aggotgggca gcctggggct gatgaagcag agatgttcgc tggatcccag gccctggcac 720 ccctcaggaa atacaagaaa aagaatattc acatctgttt aatgtgcata aagccaagga 780 aaggacagtt ccgaattcaa aaaaaaaaaa aaaaaaaa 818 <210> 158 <211> 753

<212> DNA <213> Homo sapiens <400> 158 tttttttttt tttttttaaa tatttaaott atttatttaa caaagtagaa gggaatccat 60 tgctagcttt tctgtgttgg tgtotaatat ttgggtaggg tgggggatcc ccaaoaatca 120 ggtcccctga gatagctggt cattgggctg atcattgcoa gaatettctt ctcctggggt 180 ctggoccccc aaaatgccta acccaggacc ttgggaattc tactcatccc aaatgataat 240 tecaaatgct gttacccaag gttagggtgt tgaaggaagg tagagggtgg ggcttcaggt 300 ctcaacggot tccctaacca occctcttot cttggcccag cctggttccc cccacttcca 360 ctcccctcta ctctctetag gactgggctg atgaaggcac tgcccaaaat ttcccctacc 420 cccaactttc ccctaccccc aactttcccc accagctcca caaccctgtt tggagctact 480 gcaggaccag aagcacaaag tgcggtttcc caagcctttg tccatctcag cccccagagt 540 atatctgtgc ttggggaatc tcacacagaa actcaggagc accccctgcc tgagctaagg 600 gaggtcttat ctctcagggg gggtttaagt gccgtttgca ataatgtcgt ottatttatt 660 tagcggggtg aatattttat actgtaagtg agcaatcaga gtataatgtt tatggtgaca 720 aaattaaagg otttcttata tgtttaaaaa aaa 753 <210> 159 <211> 516

<212> DNA <213> Homo sapiens <400> 159 gocttataaa gcaccaagag gctgccagtg ggacattttc tcggccctgc cagcccccag 60 gaggaaggtg ggtctgaatc tagcaccatg acggaactag agacagccat gggcatgatc 120 atagacgtct tttcccgata ttogggcagc gagggoagca cgcagaccct gaccaagggg 180 gagctcaagg tgctgatgga gaaggagcta ccaggcttcc tgcagagtgg aaaagacaag 240 gatgccgtgg ataaattgct caaggacctg gacgccaatg gagatgccca ggtggacttc 300 agtgagttca togtgttcgt ggctgcaatc acgtctgcct gtcacaagta ctttgagaag 360 gcaggactca aatgatgccc tggagatgtc acagattcct ggcagagcca tggtcccagg 420 cttcccaaaa gtgtttgtgg caattattcc cctaggctga gcctgctcat gtacctctga 480 ttaataaatg cttatgaaat gaaaaaaaaa aaaaaa 516

<210> 160 <211 > 354 <212> DNA <213> Homo sapiens <400> 160 ccagcaaagt ctcttttgac cacacgcttt atccgagatg cttagaagta tatttggctg 60 ttttatttgc atctttgatt aagatgtcta tcattgtaaa aaggtattca aaacaaaagt 120 gtactctttt attattatga atcacattgt actgagctgt gaagtcagtg ttttaaaaat 180 gtagagttta ttcatggagc atgccattga ggtttggatg gtggcaggta aaacagaaag 240 gcaagatgtc atctgacatt aggctactta taaataaatg tttatctagc ttttatttca 300 tgccctaatg aataaaacat gcttcgaaaa agaaagtaaa aaaaaaaaac aaaa 354 <210> 161 <211 >2904

<212> DNA <213> Homo sapiens <400> 161 ggcgagagag acgctcccgc tcgccgccag ctctgattgg cccagcggta ggaaaggtta 60 aaccaaaaat ttttttacag ccctagtgtg cgcctgtagc tcggaaaatt aattgtggct 120 atagccgcct cgatcgctgt ctccccagcc tcgccgcgga cgctccggga cgcgcccgcc 180 cgccgcccgg ttctcccccc ctttgggctg gtgctgctgc tgctgtgact gctgctgcga 240 aaggaggagg aggaggagga agcagcgggg gggggagcgg tgggtgtggg ggaaaocaag 300 agtacagtgg acgaggactc accccggcgt ggtgttcttt tttottcttc tttttottto 360 cttttttttt tttttttcta attcctgagg ggtggttgct gcttttgcta catgacttgc 420 cagcgcccga gcctgcggtc oaaotgogct gotgcoggag ogctoagtgc cgccgctgco 480 gcccgtgccc cccgogoccc gttcggcacc caccggtogc cgcocogocc gcgcgccgct 540 gtcccgctcc ogcgccgccg ccgocgtttc cccccgacga ctgggtgatg ctggacatgg 600 gagataggaa agaggtgaaa atgatcccca agtcctcgtt cagoatcaac agcctggtgc 660 ccgagggcct ccagaacgac aaccaecacg cgagccacgg ccaccacaac agccaccacc 720 cccagoaooa ccaccaccac caccaccatc accaccaccc gccgccgccc gccccgcaac 780 cgccgccgcc gccgcagcag cagcagccgc cgccgccgcc gagacgcggg gcccggcgcc 840 gacgacgacg aggccccagc agttgttgtt ccgccgcgca cgcacacggc gcgcctgagg 900 gccaacggca gctggcgcaa ggcgaccggo gcggccgggg gatctgcccc gtcgggccgg 960 acgagaagga gaaggcccgc gccggggggg aggagaagaa gggggcgggc gagggcggca 1020 aggacgggga ggggggcaag gagggcgaga agaagaacgg caagtacgag aagccgccgt 1080 tcagctacaa cgcgctcatc atgatggcca tgcggcagag ccccgagaag cggctcacgc 1140 tcaacggcat ctacgagttc atcatgaaga acttccctta ctaccgcgag aacaagcagg 1200 gotggcagaa ctccatccgc oacaatctgt ccctcaacaa gtgcttcgtg aaggtgccgc 1260 gccactacga cgacccgggc aagggcaact actggatgct ggacccgtcg agcgacgacg 1320 tgttcatcgg cggcaccacg ggcaagctgc ggcgctccac cacctcgccg gccaagccgg 1380 ccttcaagcg cggtgccgcg ctcacctcca ccggoctcac cttcatggac gcgccggctc 1440 cctctactgg cccatgtcgc ccttcctgtc octgcacoac ccccgccago agcactttga 1500 gttacaacgg gaccacgtcg gcctacccca gccacoccat gccctacagc tccgtgttga 1560 ctcaaaactc gctgggoaac aaccactcct cctccaccgc oaacgggctg agcgtggacc 1620 ggctggtcaa cgggggaatc ccgtacgcca cgcaccacct cacggccgcc gcgotaaccg 1680 cctcggtgcc ctgcggcctg ctggtgccct gctctgggac ctactccctc aacccctgct 1740 ccgtcaacct gctcgcgggc cagaccagtt actttttccc ccacgtcccg cacccgtcaa 1800 tgaottcgca gagcagcacg tccatgagcg ccagggccgc gtcctcctcc acgtcgccgg 1860 caggcccccc tcgacccclg coctgtgagt ctttaagacc ctctttgcca agttttacga 1920 cgggactgto tgggggactg tctgattatt tcacacatca aaatcagggg tcttcttcca 1980 accctttaat acattaacat ccctgggacc agaotgtaag tgaacgtttt acacacattt 2040 gcattgtaaa tgataattaa aaaaataagt ccaggtattt tttattaagc ccccccctoc 2100 catttctgta cgtttgttca gtctctaggg ttgtttatta ttctaacaag gtgtggagtg 2160 tcagcgaggt gcaatgtggg gagaatacat tgtagaatat aaggtttgga agtcaaatfa 2220 tagtagaatg tgtatctaaa tagtgactgc tttgccattt cattcaaacc tgacaagtct 2280 atctctaaga gccgccagat ttccatgtgt gcagtattat aagttatcat ggaactatat 2340 ggtggacgca gaccttgaga acaacctaaa ttatggggag aattttaaaa tgttaaactg 2400 taatttgtat ttaaaaagca ttcgtagtaa aggtgcccaa gaaattattt tggccattta 2460 ttgttttctc cttttcttta aagaactgtt tttttttctt ttgtttactt ttagaccaaa 2520 gattgggcgg ttctagaaaa tgcgccttgg tatactaagt attaaaacaa acaaaaagga 2580 aagttgtttc agttaacgct gcccattcaa ttgaatoaga aggggacaaa attaacgatt 2640 gccttcagtt tgtgttgtgt atattttgat gtatgtggtc actaacaggt caottttatt 2700 ttttotaaat gtagtgaaat gttaatacct attgtactta taggtaaacc ttgcaaatat 2760 gtaacctgtg ttgcgcaaat gccgcataaa tttgagtgat tgttaatgtt gtcttaaaat 2820 ttcttgattg tgactatgtg gtcatatgcc cgtgtttgtc acttacaaaa atgtttacta 2880 tgaacacaca taaataaaaa atag 2904 <210> 162 <211 >2327

<212> DNA <213> Homo sapiens <400> 162 aaaatgctta ctcttgtggg ctacttgttg tgtggaaaaa ggaaaacgga ttcattttcc 60 catcggcgac tttatgacga cagaaatgaa ccagttctgc gattagacaa tgcaccggaa 120 ccttatgatg tgagttttgg gaattctagc tactacaatc caactttgaa tgattcagcc 180 tgccagaaa gtgaagaaaa tgcacgtgat ggcattccta tggatgacat acctccactt 240 cgtacttctg tatagaacta acagcaaaaa ggcgttaaac agcaagtgtc atctacatcc 300 tagccttttg acaaattcat ctttcaaaag gttacacaaa attactgtca cgttggattt 360 tgtcaaggag aatcataaaa gcaggagacc agtagcagaa atgtagacag gatgtatoat 420 ccaaaggttt tctttcttac aatttttggc catcctgagg catttactaa gtagccttaa 480 tttgtatttt agtagtattt tcttagtaga aaatatttgt ggaatcagat aaaactaaaa 540 gatttcacca ttacagccct gcctcataac taaataataa aaattattcc accaaaaaat 600 tctaaaacaa tgaagatgac tctttactgc tctgcctgaa gccctagtac cataattcaa 660 gattgcattt tcttaaatga aaattgaaag ggtgcttttt aaagaaaatt tgacttaaag 720 otaaaaagag gaoatagccc agagtttctg ttattgggaa attgaggcaa tagaaatgac 780 agacctgtat tctagtacgt tataattttc tagatcagca cacacatgat cagcccactg 840 agttatgaag ctgacaatga ctgcattcaa cggggccatg gcaggaaagc tgaccctacc 900 caggaaagta atagcttctt taaaagtctt caaaggtttt gggaatttta acttgtctta 960 atatatctta ggottcaatt atttgggtgc cttaaaaact oaatgagaat catggtaaaa 1020 aaaaaaagtt aaccaaagaa tatacctgta cataatttgt acagttttaa gttgttagat 1080 aggaactgga tttettatgt attagacatt attgctcaat cataatggaa tagattctgc 1140 atccctaaat gtatgaacoa taaggttaaa aaagatgaat ggaaatatca aacaactttt 1200 cactgagcat cagtttcata atcaataata taagaagatt aatttggatt ctagtatgtt 1260 tcagtttgtt tttaattacc accttccttt ggtagaaaaa atatgttcct tgatgtagga 1320 aagtctaggt tttagagatt agaggatgag atcaagagtt aaattcctaa agaagcactg 1380 aatatatgaa gagagcaaac aaatcaagta ccaacctaga ggctttattt ttgaattgat 1440 tcatggtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtaacao agaaacagot 1500 ttcagaaaat aagggataga aagtaatgaa gaaagtaott accccatatt gccataaaaa 1560 tagcaaagaa gactgtccct ccattatcga acaaatatgt cacctgagta gaaaacaaac 1620 agaaatatta gtcatgcaaa ttgattataa taagccagtg aatactgttt gcactcaggt 1680 actatgattt tttctcaaat agaatcatat tattttatag tacagaaata ttatatatga 1740 attcctttca tgggtcttgo aacaatttca catgattttt ctcatgggga gaggtgaaga 1800 aacaacatta gccctcttct ctcctctctt gattcccttt ataccccacc atcatttctg 1860 attataaata attctaccat tctatggaag tatttgtggg tcacagattg tcaaactact 1920 taatgaaagt tgtatgaaat tagtttttca ggtgaggcat tcctagttgc aattcctgtt 1980 agcaaaactt ctaggagtgg ggaagttgga aaatgcagga ttcttccagt gagccagcat 2040 ttcccatagc taaccctatt ctcttagtct ttcaaaatgt agaatgggtc caataatggo 2100 tataagatgt aataaatccc atcttaattt gttttaaaag tttcataaat cactgaacac 2160 ttatgaaaca aagtgttttt taatcagata tcaactgaaa cttcataaag gatgcatagt 2220 tttataatgt tattgaatca aattttaagg cttgtattgt ttgattttaa taaagtataa 2280 tctccttttt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 2327 <210> 163 <211 > 1841

<212> DNA <213> Homo sapiens <400> 163 ggoacgaggc tgcctgcccc ccgggtgggg ctgcggctet ggcctcccag gcccatccto 60 aacagctacc ccagccaaca ocaaggccac aaggggaocc cggcctagga ggcaggaago 120 caaggtacag agagcagoct ggccctcaoc agtgcgcaag ctggggcagc aaggctgaca 180 gttgctgcat gccoagggca gggtgtggta ctggcaccca agttcagcat ggcagagctg 240 gccaacagct tgtccccgat ctgoctccag ccccaagatg cctacagccc ccaggcocct 300 tcggoagcac tgcctctgcc cacctgcctt taagagacto cagggctgct cctgtcatgc 360 agcgaaggtt ttgtctgttt caaagttcga gactoaactt gagggactgt ttttgacaat 420 ccccgctgac otccgctcct cgtggcgccc tggccctaca cccagcctgg cccagggccg 480 gctttgcctg gtgaggctgg agggagcacc aggacotgct gtctgctgtc agcccctcct 540 ggtgctggtg ccctgatgct gtgcottgto acccattgag ctgcaagagg gaccaagagg 600 gggcoacgoa gccagccaga tgcctggccc tgtgctgggg cagacaacgc tgoagagcoc 660 agggagcctg gcgctaggac gtgcgtcctt gtgacactgg cctgtctgaa ctcacctggc 720 ctgggaagoa ccgtctgccc gggcccaagc cctgccccto cagagtccag agccaggaag 780 gggctgctga gggcgagcat cctgctgggc tctctgcccg gcccacccct ccaaggggct 840 ggcctgtgag ccttgactgg gattcatgat gtggaggccc ccaacttcca gaagcagctg 900 gtactctgct cacacaagcg actgggccgg ccggccctgg acccctagac cccgagccgc 960 ctgccgactg cctgcacagg gagagcagtt gaggcccggg cagggccccc acaccagacc 1020 ccaacatagc ttccccaccc aggcaccccc tcccggggca gcaggcgtgg gagtcagggc 1080 tgcatgctcc tcccctccoa cctcacaggc ggccttaggc aagtcatttt ctgtoatcac 1140 aaggtcgcct ctgcctagtc aggtcctggc gtccagagta aggatgtgcg gcccccaggc 1200 ccccgcacac ctccctcagc accaagaccg ggaccccccc acccacgtgt ctcattgtgg 1260 ctgcctatgg actcccgggc cttgtgtgca ggooaggccc ttccactgat tttttaaagt 1320 gaaocattgc tggatctcag attctgtggc atctaaggcc tagcaggggt gggcacacgg 1380 gtcacccgag gcccatacca agactctgtt cctgccctag gcccagtctc aaaggaagco 1440 acaaggcgcg ggggccactg aggaaggaaa tgttcatttt catttgtcca aaaccacctt 1500 aagttttaag tatattaatc ttgatgcttt ttaactattg ctttttaact tgctgagatt 1560 tagaaatact gttataaaaa cttttttaat ttctgtattt tttttctgta ttgtatcttc 1620 atgggacatt aggggttttc tatggtaagc aoacctatgg ttttggtaaa aacattatca 1680 aatatatatc cagacggtto ttccotagaa gaaaaacaag tctttacacc tgataaaata 1740 ttttgcgaag agaggtgttc tttttcctta ctggtgctga aaggaaggat ggataacgag 1800 gagaaaataa aactgtgagg ctcaaaaaaa aaaaaaaaaa a 1841 . <210> 164 <211> 848

<212> DNA <213> Homo sapiens <400> 164 cctgcccttc tctatatgta ccatctccaa aaaccatgta catctccaaa aactggagta 60 gaaagttaga ttgctcaact acaactcctc tagaactcta tagotctgac atacagattc 120 acactctcct ctatttgcta agtatgtaaa gaatgttttc ttttaaaatg ttctcttttg 180 agaacaactg cttatttgtt ataaaagcat ttggttaaaa tgatgtcatc ataaagaaca 240 gtggctttgt ttcaatacat atttttgaga tgattatcta gaagccagat taataaaatc 300 agcttgtgac cttgctaagc atataaactg gaaattcaga tacattcaaa attatgggtt 360 catttaaaag tgttctacct tttgggtatg agactaatat cactaattcc tcaatagtta 420 tcatggctct atcttaatta attagaaaat atgtgtgttt aattctttga gaattaaaat 480 agagaatatt aacagagggt taaaaactgc ttcaactoca ataagataaa ggaagctcaa 540 aatctatgag ctgagtgttc aattagcttt gcctactgag ttcaatttta tgtcaataca 600 acagtggatc agacagtacg actttgaact ggtgaatgta aacaattgtt tttoacctaa 660 gctgctttgg aagaactgat gcttgctgct aactaaagtt ttggatgtat cgatttagag 720 aaccaattaa tacctgcaaa ataaagcata ctgtggtact tctgtttgat ctagtatgtg 780 tgattttaga ttgatggatt aaaaattaat aaagatoata cattccatac caaaaaaaaa 840 aaaaaaaa 848 <210> 165 <211> 1767

<212> DNA <213> Homo sapiens <400> 165 ccagaagcct gcatttctgc attctgctta attccctttc cttagatttg aaagaagcca 60 acactaaacc acaaatatac aacaaggcca ttttctcaaa cgagagtcag cctttaacga 120 aatgaccatg gttgacacag agatgccatt ctggcccace aactttggga tcagctccgt 180 ggatctctcc gtaatggaag accactccca ctcctttgat atcaagccct tcactactgt 240 tgacttctcc agcatttcta ctccacatta cgaagacatt ccattcacaa gaacagatcc 300 agtggttgca gattacaagt atgacctgaa acttcaagag taccaaagtg caatcaaagt 360 ggagcctgca tctccacctt attattctga gaagactcag ctotacaata agcctcatga 420 agagccttcc aactccctca tggcaattga atgtcgtgtc tgtggagata aagcttctgg 480 atttcactat ggagttcatg cttgtgaagg atgcaagggt ttcttccgga gaacaatcag 540 attgaagctt atctatgaca gatgtgatct taactgtcgg atccacaaaa aaagtagaaa 600 taaatgtcag tactgtcggt ttcagaaatg ccttgoagtg gggatgtctc ataatgccat 660 caggtttggg cggatgccac aggccgagaa ggagaagctg ttggcggaga tctccagtga 720 tatcgaccag ctgaatccag agtccgctga cctccgggcc ctggoaaaac atttgtatga 780 ctcatacata aagtccttcc cgctgaccaa agcaaaggcg agggcgatct tgaoaggaaa 840 gacaacagac aaatcaccat tcgttatcta tgacatgaat tccttaatga tgggagaaga 900 taaaatcaag ttcaaacaca tcacccccct gcaggagoag agcaaagagg tggcoatccg 960 catctttcag ggctgccagt ttcgctocgt ggaggctgtg caggagatca oagagtatgc 1020 caaaagcatt cctggttttg taaatottga cttgaacgac caagtaactc tcctcaaata 1080 tggagtccac gagatcattt acacaatgct ggcctccttg atgaataaag atggggttct 1140 catatccgag ggccaaggot tcatgacaag ggagtttcta aagagcctgo gaaagccttt 1200 tggtgacttt atggagocca agtttgagtt tgctgtgaag ttcaatgoao tggaattaga 1260 tgacagcgac ttggcaatat ttattgctgt cattattctc agtggagacc gcccaggttt 1320 gctgaatgtg aagcccattg aagacattea agacaaoctg ctacaagccc tggagctcca 1380 gctgaagctg aaccaccctg agtcctcaca gctgtttgcc aagctgotcc agaaaatgac 1440 agacctoaga cagattgtca cggaacaogt goagctactg caggtgatca agaagacgga 1500 gacagacatg agtcttcacc cgctcctgca ggagatctac aaggaottgt actagcagag 1560 agtcctgago cactgccaac atttcccttc ttcoagttgc actattctga gggaaaatot 1620 gacacctaag aaatttaotg tgaaaaagca ttttaaaaag aaaaggtttt agaatatgat 1680 ctattttatg catattgttt ataaagacac atttacaatt tacttttaat attaaaaatt 1740 accatattat gaaaaaaaaa aaaaaaa 1767 <210> 166 <211 >8448

<212> DNA <213> Homo sapiens <400> 166 gcagtggttt ctcctccttc ctcccaggaa gggocaggaa aatggccctg gtcctggaga 60 tcttcaccct gctggcctcc atctgctggg tgtcggccaa tatcttcgag taccaggttg 120 atgcccagcc ccttcgtccc tgtgagctgc agagggaaac ggcctttctg aagcaagcag 180 actacgtgcc ccagtgtgca gaggatggca gcttccagac tgtccagtgc cagaacgacg 240 gccgctcctg ctggtgtgtg ggtgccaacg gcagtgaagt gctgggcagc aggcagccag 300 gacggcctgt ggcttgtctg tcattttgtc agctacagaa acagcagatc ttactgagtg 360 gotacattaa cagcacagac acctcctaco tccctcagtg tcaggattca ggggactacg 420 cgcctgttca gtgtgatgtg cagoatgtcc agtgctggtg tgtggacgca gaggggatgg 480 aggtgtatgg gacccgcoag otggggaggc caaagcgatg tccaaggagc tgtgaaataa 540 gaaatcgtcg tcttctccac ggggtgggag ataagtcacc accccagtgt tctgcggagg 600 gagagtttat gcctgtccag tgoaaatttg tcaacaccac agacatgatg atttttgatc 660 tggtcoacag ctacaacagg tttccagatg catttgtgac cttcagttcc ttocagagga 720 ggttcoctga ggtatctggg tattgccact gtgctgaoag ooaagggcgg gaactggctg 780 agacaggttt ggagttgtta ctggatgaaa tttatgaoao catttttgct ggcctggacc 840 ttccttccac cttcaotgaa accaccctgt accggatact gcagagacgg ttcctcgcag 900 ttcaatcagt catctctggc agattccgat gccccacaaa atgtgaagtg gagcggttta 960 cagcaaccag ctttggtcac ccctatgttc caagctgccg ccgaaatggc gactatcagg 1020 oggtgcagtg ccagacggaa gggccctgct ggtgtgtgga cgcccagggg aaggaaatgc 1080 atggaacccg gcagcaaggg gagccgccat cttgtgctga aggccaatct tgtgcctccg 1140 aaaggcagca ggccttgtcc agactctact ttgggacctc aggctacttc agccagcacg 1200 acctgttctc ttccccagag aaaagatggg cctctccaag agtagccaga tttgccacat 1260 cctgcccacc cacgatcaag gagctctttg tggactctgg gcttctccgc ccaatggtgg 1320 agggacagag ccaacagttt tctgtctcag aaaatcttct caaagaagcc atccgagcaa 1380 tttttccctc ccgagggctg gctcgtcttg cccttcagtt taccaccaac ccaaagagac 1440 tccagcaaaa cctttttgga gggaaatttt tggtgaatgt tggccagttt aacttgtctg 1500 gagcccttgg cacaagaggc acatttaact tcagtcaatt tttccagcaa cttggtcttg 1560 caagcttctt gaatggaggg agacaagaag atttggccaa gccactctct gtgggattag 1620 attcaaattc ttccacagga acccctgaag ctgctaagaa ggatggtact atgaataagc 1680 caactgtggg cagctttggc tttgaaatta acctacaaga gaaccaaaat gccctcaaat 1740 tccttgcttc tctcctggag cttccagaat tccttctctt cttgcaacat gctatctctg 1800 tgccagaaga tgtggcaaga gatttaggtg atgtgatgga aacggtactc gactcccaga 1860 cctgtgagca gacacctgaa aggctatttg tcccatcatg cacgacagaa ggaagctatg 1920 aggatgtcca atgcttttcc ggagagtgct ggtgtgtgaa ttcctggggc aaagagcttc 1980 caggctcaag agtcagagat ggacagccaa ggtgccccac agactgtgaa aagcaaaggg 2040 ctcgcatgca aagcctcatg ggcagccagc ctgctggctc caccttgttt gtccctgctt 2100 gtactagtga gggacatttc ctgcctgtcc agtgcttcaa ctcagagtgc tactgtgttg 2160 atgctgaggg tcaggccatt cctggaactc gaagtgcaat agggaagccc aagaaatgcc 2220 ccacgccctg tcaattacag tctgagcaag ctttcctcag gacggtgcag gccctgctct 2280 ctaactccag catgctaccc accctttccg acacctacat cccacagtgc agcaccgatg 2340 ggcagtggag acaagtgcaa tgcaatgggc ctcctgagca ggtcttcgag ttgtaccaac 2400 gatgggaggc tcagaacaag ggccaggatc tgacgcctgc caagctgcta gtgaagatca 2460 tgagctacag agaagcagct tccggaaact tcagtctctt tattcaaagt ctgtatgagg 2520 ctggccagca agatgtcttc ccggtgctgt cacaataccc ttctctgcaa gatgtcccac 2580 tagcagcact ggaagggaaa cggccccagc ccagggagaa tatcctcctg gagccctacc 2640 tcttctggca gatcttaaat ggccaactca gccaataccc ggggtcctac tcagacttca 2700 gcactccttt ggcacatttt gatcttcgga actgctggtg tgtggatgag gctggccaag 2760 aactggaagg aatgcggtct gagccaagca agctcccaac gtgtcctggc tcctgtgagg 2820 aagcaaagct ccgtgtactg cagttcatta gggaaacgga agagattgtt tcagcttcca 2880 acagttctcg gttccctctg ggggagagtt tcctggtggc caagggaatc cggctgagga 2940 atgaggacct cggccttcct ccgctcttcc cgccccggga ggctttcgcg gagtttctgc 3000 gtgggagtga ttacgccatt cgcctggcgg ctcagtctac cttaagcttc tatcagagac 3060 gccgcttttc cccggacgac tcggctggag catccgccct tctgcggtcg ggcccctaca 3120 tgccacagtg tgatgcgttt ggaagttggg agcctgtgca gtgccacgct gggactgggc 3180 actgctggtg tgtagatgag aaaggagggt tcatccctgg ctcactgact gcccgctctc 3240 tgcagattcc acagtgcccg acaacctgcg agaaatctcg aaccagtggg ctgctttcca 3300 gttggaaaca ggctagatcc caagaaaacc catctccaaa agacctgttc gtcccagcct 3360 gcctagaaac aggagaatat gccaggctgc aggcatcggg ggctggcacc tggtgtgtgg 3420 accctgcatc aggagaagag ttgcggcctg gctcgagcag cagtgcccag tgcccaagcc 3480 tctgcaatgt gctcaagagt ggagtcctct ctaggagagt cagcccaggc tatgtcccag 3540 cctgcagggc agaggatggg ggcttttccc cagtgcaatg tgaccaggcc cagggcagct 3600 gctggtgtgt catggacagc ggagaagagg tgcctgggac gcgcgtgacc gggggccagc 3660 ccgcctgtga gagcccgcgg tgtccgctgc cattcaacgc gtcggaggtg gttggtggaa 3720 caatcctgtg tgagacaatc tcgggcccca caggctctgc catgcagcag tgccaattgc 3780 tgtgccgcca aggctcctgg agcgtgtttc caccagggcc attgatatgt agcctggaga 3840 gcggacgctg ggagtcacag ctgcctcagc cccgggcctg ccaacggccc cagctgtggc 3900 agaccatcca gacccaaggg cactttcagc tccagctccc gccgggcaag atgtgcagtg 3960 ctgactacgc gggtttgctg cagactttcc aggttttcat attggatgag ctgacagccc 4020 gcggcttctg ccagatccag gtgaagactt ttggcaccct ggtttccatt cctgtctgca 4080 acaactcctc tgtgcaggtg ggttgtctga ccagggagcg tttaggagtg aatgttacat 4140 ggaaatcacg gcttgaggac atcccagtgg cttctcttcc tgacttacat gacatlgaga 4200 gagccttggt gggcaaggat ctccttgggc gcttcacaga tctgatccag agtggctcat 4260 tccagcttca tctggactcc aagacgttcc cagcggaaac catccgcttc ctccaagggg 4320 accactttgg cacctctcct aggacacggt ttgggtgctc ggaaggattc taccaagtct 4380 tgacaagtga ggccagtcag gacggactgg gatgcgttaa gtgccatgaa ggaagctatt 4440 cccaagatga ggaatgcatt ccttgtcctg ttggattcta ccaagaacag gcagggagct 4500 tggcctgtgt cccatgtcct gtgggcagaa cgaccatttc tgccggagct ttcagccaga 4560 ctcactgtgt cactgactgt cagaggaacg aagcaggcct gcaalgtgac cagaatggcc 4620 agtatcgagc cagccagaag gacaggggca gtgggaaggc cttctgtgtg gacggcgagg 4680 ggcggaggct gccatggtgg gaaacagagg cccctcttga ggactcacag tgtttgatga 4740 tgcagaagtt tgagaaggtt ccagaatcaa aggtgatctt cgacgccaat gctcctgtgg 4800 ctgtcagatc caaagttcct gattctgagt tccccgtgat gcagtgcttg acagattgca 4860 cagaggacga ggcctgcagc ttcttoaccg tgtccacgac ggagccagag atttcctgtg 4920 atttctatgc ttggacaagt gacaatgttg cctgcatgac ttctgaccag aaacgagatg 4980 cactggggaa ctcaaaggcc accagctttg gaagtcttcg ctgccaggtg aaagtgagga 5040 gccatggtca agattctcca gctgtgtatt tgaaaaaggg ccaaggatcc accacaacac 5100 ttcagaaacg ctttgaaccc actggtttcc aaaacatgct ttctggattg tacaacccca 5160 ttgtgttctc agcctcagga gccaatctaa ccgatgctca cctcttctgt cttcttgcat 5220 gcgaccgtga tctgtgtlgc gatggcttcg tcctcacaca ggttcaagga ggtgccatca 5280 tctgtgggtc gctgagctca cccagtgtcc tgctttgtaa tgtcaaagac tggatggatc 5340 cctctgaagc ctgggctaat gctacatgtc ctggtgtgac atatgaccag gagagccacc 5400 aggtgatatt gcgtcttgga gaccaggagt tcatcaagag tctgacaccc ttagaaggaa 5460 ctcaagacac ctttaccaat tttcagcagg tttatctctg gaaagattct gacatggggt 5520 ctcggcctga gtctatggga tgtagaaaaa acacagtgcc aaggccagca tctccaacag 5580 aagcaggttt gacaaoagaa cttttctccc ctgtggacct caaccaggtc attgtcaatg 5640 gaaatcaatc actatccagc cagaagcact ggcttttcaa gcacctgttt tcagcccagc 5700 aggcaaacct atggtgcctt tctcgttgtg tgcaggagca ctctttctgt cagctcgcag 5760 agataacaga gagtgcatcc ttgtacttca cctgcaccct ctacccagag gcacaggtgt 5820 gtgatgacat catggagtcc aatacccagg gctgcagact gatcctgcct cagatgccaa 5880 aggccctgtt ccggaagaaa gttatactgg aagataaagt gaagaacttt tacactcgcc 5940 tgccgttcca aaaactgatg gggatatcca ttagaaataa agtgcccatg tctgaaaaat 6000 ctatttctaa tgggttcttt gaatgtgaac gacggtgcga tgcggaccca tgctgcactg 6060 gctttggatt tctaaatgtt tcccagttaa aaggaggaga ggtgacatgt ctcactctga 6120 acagcttggg aattcagatg tgcagtgagg agaatggagg agcctggcgc attttggact 6180 gtggctctcc tgacattgaa gtccacacct atcccttcgg atggtaccag aagcccattg 6240 ctcaaaataa tgctcccagt ttttgccctt tggttgttct gccttccctc acagagaaag 6300 tgtctctgga atcgtggcag tccctggccc tctcttcagt ggttgttgat ccatccatta 6360 ggcactttga tgttgcccat gtcagcactg ctgccaccag caatttctct gctgtccgag 6420 acctctgttt gtcggaatgt tcccaacatg aggcctgtct catcaccact ctgcaaaccc 6480 aactcggggc tgtgagatgt atgttotatg ctgatactca aagctgcaca catagtctgc 6540 agggtcggaa ctgccgactt ctgcttcgtg aagaggccac ccacatctac cggaagccag 6600 gaatctctct gctcagctat gaggcatctg taccttctgt gcccatttcc acccatggcc 6660 ggctgctggg caggtcccag gccatccagg tgggtacctc atggaagcaa gtggaccagt 6720 tccttggagt tccatatgct gccccgccco tggcagagag gcacttocag gcaccagagc 6780 ccttgaactg gacaggctcc tgggatgcca gcaagccaag ggccagctgc tggcagccag 6840 gcacoagaac atccacgtct cctggagtca gtgaagattg tttgtatctc aatgtgttca 6900 tccctcagaa tgtggcccct aacgcgtctg tgctggtgtt cttccacaac accatggaca 6960 gggaggagag tgaaggatgg ccggctatcg acggctcctt cttggotgct gttggcaacc 7020 tcatcgtggt cactgccagc taccgagtgg gtgtcttcgg cttcctgagt tctggatocg 7080 gagaggtgag tggcaactgg gggctgctgg accaggtggc ggctctgacc tgggtgcaga 7140 cccacatccg aggatttggc ggggaccctc ggcgcgtgtc cctggcagca gaccgtggog 7200 gggctgatgt ggccagcatc caccttctca cggccagggo caccaactcc caacttttcc 7260 ggagagctgt gctgatggga ggctccgcac tctcccoggc cgccgtcatc agccatgaga 7320 gggctcagca gcaggcaatt gctttggcaa aggaggtcag ttgccccatg tcatccagcc 7380 aagaagtggt gtoctgcctc cgccagaagc ctgccaatgt cctcaatgat gcccagacca 7440 agctcctggc cgtgagtggc cctttccact actggggtcc tgtgatcgat ggccacttcc 7500 tccgtgagcc tccagccaga gcactgaaga ggtctttatg ggtagaggtc gatctgctca 7560 ttgggagttc tcaggacgac gggctcatca acagagcaaa ggctgtgaag caatttgagg - 7620 ....... aaagtcgagg ccggaccagt agoaaaacag cottttacca ggcactgcag aattctctgg 7680 gtggcgagga ctoagatgcc cgcgtcgagg ctgctgctac atggtattac tctctggagc 7740 actccacgga tgaotatgoc tccttctccc gggctctgga gaatgccaoc cgggactaot 7800 ttatcatctg ccctataato gacatggcca gtgcctgggc aaagagggco cgaggaaaog 7860 tcttcatgta ccatgctcct gaaaactacg gccatggcag octggagctg otggcggatg 7920 ttcagtttgc cttggggctt cccttctacc cagcctacga ggggcagttt tctctggagg 7980 agaagagcct gtcgctgaaa atcatgcagt acttttccca cttcatcaga tcaggaaatc 8040 ccaactaccc ttatgagttc tcacggaaag tacccacatt tgcaaccccc tggcctgact 8100 ttgtaccccg tgctggtgga gagaactaca aggagttcag tgagctgctc cccaatcgac 8160 agggcctgaa gaaagcogac tgctocttct ggtccaagta catctogtct ctgaagacat 8220 ctgcagatgg agccaagggc gggcagtcag cagagagtga agaggaggag ttgacggctg 8280 gatctgggct aagagaagat ctcctaagcc tccaggaacc aggctctaag acotacagca 8340 agtgaccagc ccttgagctc cccaaaaacc tcacccgagg ctgcccacta tggtcatctt 8400 tttctctaaa atagttactt accttcaata aagtatctac atgoggtg 8448 <210> 167 <211 >4424

<212> DNA <213> Homo sapiens <400> 167 agatctctcc agatcacact gtcacgtgta cctagcacat ctcgagaact cctttgggcc 60 gtctggggcc cgggaaggaa gcctgagttc tcaagattcc aggactgaga gtgccagctt 120 gtctcaaagc caggtcaatg gtttctttgc cagccattta ggtgaccaaa cctggcagga 180 atcacagcat ggcagccctt ooccatctgt aatatccaaa gccaccgaga aagagacttt 240 oactgatagt aaccaaagca aaactaaaaa gccaggcatt tctgatgtaa ctgattactc 300 agaccgtgga gattcagaca tggatgaagc cacttactco agcagtoagg atoatcaaac 360 accaaaacag gaatcttcct cttcagtgaa tacatccaac aagatgaatt ttaaaacttt 420 tocttcatca cctcctaggt ctggagatat ctttgaggtt gaactggcta aaaatgataa 480 cagcttgggg ataagtgtca cgggaggtgt gaatacgagt gtoagacatg gtggcattta 540 tgtgaaagct gttattcoco agggagcagc agagtctgat ggtagaattc acaaaggtga 600 tcgcgtccta gctgtcaatg gagttagtct agaaggagcc acccataagc aagctgtgga 660 aacactgaga aatacaggac aggtggrtca tctgttarta gaaaagggac aatctccaac 720 atctaaagaa catgtcccgg taaccccaca gtgtaccctt tcagatcaga atgcccaagg 780 tcaaggccca gaaaaagtga agaaaacaac tcaggtcaaa gactacagct ttgtcactga 840 agaaaataca tttgaggtaa aattatttaa aaatagctca ggtctaggat tcagtttttc 900 tcgagaagat aatcttatac cggagcaaat taatgccagc atagtaaggg ttaaaaagct 960 ctttcctgga cagccagcag cagaaagtgg aaaaattgat gtaggagatg ttatcttgaa 1020 agtgaatgga gcctctttga aaggactatc tcagcaggaa gtcatatctg ctctcagggg 1080 aactgctcca gaagtattct tgcttctctg cagacctcca cctggtgtgc taccggaaat 1140 tgatactgcg cttttgaccc cacttcagtc tccagcacaa gtacttccaa acagcagtaa 1200 agactcttct cagccatcat gtgtggagca aagcaccagc tcagatgaaa atgaaatgtc 1260 agacaaaagc aaaaaacagt gcaagtcccc atccagaaaa gacagttaca gtgacagcag 1320 tgggagtgga gaagatgact tagtgacagc tccagcaaac atatcaaatt cgacctggag 1380 ttcagctttg catcagactc taagcaacat ggtatcacag gcacagagtc atcatgaagc 1440 accaagagtc aagaagatac catttgtacc atgttttact atcctcagga aaaggcccaa 1500 taaaccagag tttgaggaca gtaatccttc ccctctacca ccggatatgg ctcctgggca 1560 gagttatcaa ccccaatcag aatctgcttc ctctagttcg atggataagt atcatataca 1620 tcacatttct gaaccaacta gacaagaaaa ctggacacct ttgaaaaatg acttggaaaa 1680 tcaccttgaa gactttgaac tggaagtaga actcctcatt accctaatta aatcagaaaa 1740 aggaagcctg ggttttacag taaccaaagg caatcagaga attggttgtt atgttcatga 1800 tgtcatacag gatccagcca aaagtgatgg aaggctaaaa cctggggacc ggctcataaa 1860 ggttaatgat acagatgtta ctaatatgac tcatacagat gcagttaatc tgctccgggg 1920 atccaaaaca gtcagattag ttattggacg agttctagaa ttacccagaa taccaatgtt 1980 ’' gccica tifg c taccggåca faa’cactaåc' gtgcaacåaå gaggagttgg gtttttcctt~'2040 " atgtggaggt catgacagcc tttatcaagt ggtatatatt agtgatatta atccaaggtc 2100 cgtcgcagcc attgagggta atctccagct attagatgtc atccattatg tgaacggagt 2160 cagcacacaa ggaatgacct tggaggaagt taacagagca ttagacatgt cacttccttc 2220 attggtattg aaagcaacaa gaaatgatct tccagtggtc cccagctcaa agaggtctgc 2280 tgtttcagct ccaaagtcaa ccaaaggcaa tggttcctac agtgtggggt cttgcagcca 2340 gcctgccctc actcctaatg attcattctc cacggttgct ggggaagaaa taaatgaaat 2400 atcgtacccc aaaggaaaat gttctactta tcagataaag ggatcaccaa acttgactct 2460 gcccaaagaa tcttatatac aagaagatga catttatgat gattcccaag aagctgaagt 2520 tatccagtct ctgctggatg ttgtggatga ggagtcccag aatcttttaa acgaaaataa 2580 tgcagcagga tactcctgtg gtccaggtac attaaagatg aatgggaagt tatcagaaga 2640 gagaacagaa gatacagact gcgatggttc accttlacut gagtatttta ctgaggccac 2700 caaaatgaat ggctgtgaag aatattgtga agaaaaagta aaaagtgaaa gcttaattca 2760 gaagccacaa gaaaagaaga ctgatgatga tgaaataaca tggggaaatg atgagttgcc 2820 aatagagaga acaaaccatg aagattctga taaagatcat tcctttctga caaacgatga 2880 gctcgctgta ctccctgtcg tcaaagtgct tccctctggt aaatacacgg gcgccaactt 2940 aaaatcagtc attcgagtcc tgcgggttgc tagatcagga attccttcta aggagctgga 3000 gaatcttcaa gaattaaaac ctttggatca gtgtctaatt gggcaaacta aggaaaacag 3060 aaggaagaac agatataaaa atatacttcc ctatgatgct acaagagtgc ctcttggaga 3120 tgaaggtggc tatatcaatg ccagcttcat taagatacca gttgggaaag aagagttcgt 3180 ttacattgcc tgccaaggac cactgcctac aactgttgga gacttctggc agatgatttg 3240 ggagcaaaaa tccacagtga tagccatgat gactcaagaa gtagaaggag aaaaaatcaa 3300 atgccagcgc tattggccca acatcctagg caaaacaaca atggtcagca acagacttcg 3360 actggctctt gtgagaatgc agcagctgaa gggctttgtg gtgagggcaa tgacccttga 3420 agatattcag accagagagg tgcgccatat ttctcatctg aatttcactg cciggccaga 3480 ccatgataca ccttctcaac cagatgatct gcttactttt atctcctaca tgagacacat 3540 ccacagatca ggcccaatca ttacgcactg cagtgctggc attggacgtt cagggaccct 3600 gatttgcata gatgtggttc tgggattaat cagtcaggat cttgattttg acatctctga 3660 tttggtgcgc tgcatgagac tacaaagaca cggaatggtt cagacagagg atcaatatat 3720 tttctgctat caagtcatcc tttatgtcct gacacgtctt caagcagaag aagagcaaaa 3780 acagcagcct cagcttctga agtgacatga aaagagcctc tggatgcatt tccatttctc 3840 tccttaacct ccagcagact cctgctctct atccaaaata aagatcacag agcagcaagt 3900 tcatacaaca tgcatgttct cctctatctt agaggggtat tcttcttgaa aataaaaaat 3960 attgaaatgc tgtattttta cagctacttt aacctatgat aattatttac aaaattttaa 4020 cactaaccaa acaatgcaga tcttagggat gattaaaggc agcatttgat gatagcagac 4080 attgttacaa ggacatggtg agtctatttt taatgcacca atcttgttta tagcaaaaat 4140 gttttccaat attttaataa agtagttatt tataggcata cttgaaacca gtatttaagc 4200 tttaaatgac agtaatattg gcatagaaaa aagtagcaaa tgtttactgt atcaatttct 4260 aatgtttact atatagaatt tcctgtaata tatttatata ctttttcatg aaaatggagt 4320 tatcagttat ctgtttgtta ctgcatcatc tgtttgtaat cattatctca ctttgtaaat 4380 aaaaacacac cttaaaacat gaacaagcca aaaaaaaaaa aaaa 4424 <210> 168 <211 > 1450

<212> DNA <213> Homo sapiens <400> 168 ccaggcagca gttagcccgc cgcccgcctg tgtgtcccca gagccatgga gagagccagt 60 ctgatccaga aggccaagct ggcagagcag gccgaacgct atgaggacat ggcagccttc 120 ccaggcagca gttagcccgc cgcccgcctg tgtgtcccca gagccatgga gagagccagt 180 ctgatccaga aggccaagct ggcagagcag gccgaacgct atgaggacat ggcagccttc 240 atgaaaggcg ccgtggagaa gggcgaggag ctctcctgcg aagagcgaaa cctgctctca 300 gtagcctata agaacgtggt gggcggccag agggctgcct ggagggtgct gtccagtatt 3 60 gagcagaaaa gcaacgagga gggctcggag gagaaggggc ccgaggtgcg tgagtaccgg 420 — gagaaggtgg-agactgagct ccagggcgtg-tgcgacaccg-tgotgggcct- getggacagc - 480-............- cacctcatca aggaggccgg ggacgccgag agccgggtct tctacctgaa gatgaagggt 540 gactactacc gctacctggc cgaggtggcc accggtgacg acaagaagcg catcattgac 600 tcagcccggt cagcctacca ggaggccatg gacatcagca agaaggagat gccgcccacc 660 aaccccatcc gcctgggcct ggccctgaac ttttccgtct tccactacga gatcgccaac 720 agccccgagg aggccatctc tctggccaag accactttcg acgaggccat ggctgatctg 780 cacaccctca gcgaggactc ctacaaagac agcaccctca tcatgcagct gctgcgagac 840 aacctgacac tgtggacggc cgacaacgcc ggggaagagg ggggcgaggc tccccaggag 900 ccccagagct gagtgttgcc cgccaccgcc ccgccctgcc ccctccagtc cccgccctgc 960 cgagaggact agtatggggt gggaggcccc acccttctcc cctaggcgct gttcttgctc 1020 caaagggctc cgtggagagg gactggcaga gctgaggcca cctggggctg gggatcccac 1080 tcttcttgca gctgttgagc gcacctaacc actggtcatg cccccacccc tgctctccgc 1140 acccgcttcc tcccgacccc aggaccaggc tacttctccc ctcctcttgc ctccctcctg 1200 cccctgctgc ctcttgattc gtaggaattg aggagtgtct ccgccttgtg gctgagaact 1260 ggacagtggc aggggctgga gatgggtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgcgcg 1320 cgcgccagtg caagaccgag actgagggaa agcatgtctg ctgggtgtga ccatgtttcc 1380 tctcaataaa gttcccctgt gacactcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1440 aaaaaaaaaa 1450 <210> 169 <211> 798

<212> DNA <213> Homo sapiens <400> 169 cggccgcgag gccctgagat gaggctcoaa agaccccgac aggccccggc gggtgggagg 60 cgcgcgcccc ggggcgggcg gggctccccc taccggccag acccggggag aggcgcgcgg 120 aggctgcgaa ggttccagaa gggcggggag ggggcgccgc gogctgaccc tccctgggca 180 ccgctgggga cgatggogct gctcgccttg ctgctggtcg tggccctacc gcgggtgtgg 240 acagacgcca acctgaotgo gagacaacga gatccagagg actcccagcg aacggacgag 300 ggtgacaata gagtgtggtg tcatgtttgt gagagagaaa acactttcga gtgccagaac 360 ccaaggaggt gcaaatggac agagccatac tgcgttatag cggccgtgaa aatatttcca 420 cgttttttca tggttgcgaa gcagtgctcc gctggttgtg cagcgatgga gagacccaag 480 ccagaggaga agcggtttct cctggaagag cccatgccct tcttttacct caagtgttgt 540 aaaattcgct actgcaattt agaggggcca cctatcaact catcagtgtt caaagaatat 600 gctgggagca tgggtgagag ctgtggtggg ctgtggotgg ccatcctcct gctgctggcc 660 tccattgcag ccggcctcag cctgtcttga gccacgggac tgccacagac tgagccttcc 720 ggagcatgga ctcgctccag accgttgtca octgttgcat taaacttgtt ttctgttgat 780 taaaaaaaaa aaaaaaaa 798 <210> 170 <211 >3726

<212> DNA <213> Homo sapiens <400> 170 ttcagccgga acgttactcc gtgtccaccc ggatcgtgtg tgtgatcgag gctgcggaga 60 cgcctttcac ggggggtgtc gaggtggacg tcttcgggaa actgggccgt tcgcotccca 120 atgtocagtt caccttccaa oagcccaagc otctcagtgt ggagccgcag cagggaccgc 180 aggcgggcgg cacoacactg accatccacg gcacccacot ggacacgggc tcccaggagg 240 acgtgcgggt gaccctcaac ggcgtcccgt gtaaagtgac gaagtttggg gcgcagctcc 300 agtgtgtcac tggcccccag gcgacacggg gccagatgct tctggaggtc tcctacgggg 360 ggtcccccgt gcccaacccc ggcatcttct tcacctaccg cgaaaacccc gtactgcgag 420 ccttcgagoo gctacgaagc tttgccagtg gtggccgcag catcaacgtc acgggtcagg 480 gcttcagcct gatccagagg tttgcoatgg tggtcatcgc ggagcccctg cagtcctggc 540 „_agQc.gc.cgcg^ggaggo.tgaa-tccc.tgoagC-Ccatgacggtggtgggtaca-gactacgtgt--600----------- tccacaatga caccaaggtc gtcttcctgt ccccggctgt goctgaggag ccagaggtct 660 acaaoctcac ggtgctgatc gagatggaog ggcaccgtgc cctgctcaga acagaggccg 720 gggccttcga gtacgtgcct gaocccacco ttgagaaott cacaggtggc gtcaagaagc 780 aggtcaacaa gotcatccac gcccggggca ccaatctgaa caaggcgatg acgctgcagg 840 aggccgaggc cttcgtgggt gccgagcgct gcaccatgaa gacgctgacg gagaccgacc 900 tgtactgtga gcccccggag gtgcagcccc cgcccaagcg gcggcagaaa cgagacacoa 960 oacacaacct gcccgagttc attgtgaagt tcggctctcg cgagtgggtg otgggccgcg 1020 tggagtacga cacacgggtg agcgacgtgc cgctcagcct catcttgccg ctggtcatcg 1080 tgcccatggt ggtcgtcatc gcggtgtctg tctactgcta ctggaggaag agccagcagg 1140 ccgaacgaga gtatgagaag atcaagtccc agctggaggg cctggaggag agcgtgcggg 1200 accgctgcaa gaaggaattc acagacctga tgatcgagat ggaggaccag accaacgacg 1260 tgcacgaggc cggcatcccc gtgctggact acaagaccta caccgaccgc gtcttcttcc 1320 tgccctccaa ggacggcgac aaggacgtga tgatcaccgg caagctggac atccccgagc 1380 cgcggcggcc ggtggtggag caggccctct accagttctc caaoctgctg aacagcaagt 1440 ctttcctcat caatttcatc cacaccctgg agaaccagcg ggagttctcg gcccgcgcca 1500 aggtctactt cgcgtccctg ctgacggtgg cgctgoacgg gaaactggag tactacacgg 1560 acatcatgca cacgctcttc ctggagctcc tggagcagta cgtggtggcc aagaaoccca 1620 agctgatgct gcgcaggtct gagactgtgg tggagaggat gotgtccaao tggatgtcca 1680 tctgcctgta ccagtacctc aaggacagtg ccggggagcc cctgtacaag ctcttcaagg 1740 ccatcaaaoa tcaggtggaa aagggcocgg tggatgcggt acagaagaag gccaagtaca 1800 ctctcaacga oacggggctg ctgggggatg atgtggagta cgcacccctg acggtgagcg 1860 tgatcgtgca ggacgaggga gtggacgcca tcccggtgaa ggtcctcaac tgtgacacca 1920 tctcocaggt caaggagaag atcattgacc aggtgtacog tgggcagccc tgctcctgct 1980 ggcccaggcc agacagcgtg gtcctggagt ggcgtccggg ctccacagcg cagatcctgt 2040 cggacctgga cctgacgtca cagcgggagg gccggtggaa gogcgtcaac acccttatgc 2100 actacaatgt ccgggatgga gccaccctca tcctgtccaa ggtgggggtc tcccagcagc 2160 cggaggacag ccagcaggac ctgcctgggg agcgccatgc cctcctggag gaggagaacc 2220 gggtgtggca cctggtgcgg ccgaccgacg aggtggacga gggcaagtcc aagagaggca 2280 gcgtgaaaga gaaggagcgg acgaaggoca tcaccgagat ctacctgacg cggctgctct 2340 cagtcaaggg cacactgcag cagtttgtgg acaacttctt ccagagcgtg ctggcgcctg 2400 ggcåcgcggt gccacctgca gtcaagtact tcttcgactt cctggacgag caggcagaga 2460 agcacaacat ccaggatgaa gacaccatcc acatctggaa gacgaacagt ttaccgctcc 2520 ggttctgggt gaacatcctc aagaaccccc acttcatctt tgacgtgcat gtocacgagg 2580 tggtggacgc ctcgctgtca gtcatcgcgc agaccttcat ggatgcctgc acgcgcacgg 2640 agcataagct gagccgcgat tctcccagca acaagotgct gtacgccaag gagatctcca 2700 cctacaagaa gatggtggag gattactaca aggggatccg gcagatggtg caggtcagcg 2760 accaggacat gaacacacae ctggcagaga tttcccgggc gcacacggac tccttgaaca 2820 ccctogtggc actccaccag ctctaccaat acacgcagaa gtactatgac gagatcatca 2880 atgccttgga ggaggatoct gccgcccaga agacgcagct ggccttccgc ctgcagcaga 2940 ttgccgctgc actggagaac aaggtcactg acctctgacc tacaatctcc agtgctgcct 3000 tgggacatag gtacctgagg tacotgagag cocctcaggg gaggaggccg agtggctgtg 3060 gotgaggccc ccaccctccc ctggaaogcg ecccaagccg gagtgggtgc agccggaacc 3120 cgcccagcgt ctagactgta gcatcttcct otgagcaata ccgccgggca cogcaccagc 3180 accagcccca gccccagctc cctccggccg cagaaccagc atcgggtgtt cactgtcgag 3240 tctcgagtga tttgaaaatg tgccttacgc tgccacgctg ggggcagctg gcctccgcct 3300 ccgcccacgc acoagcagcc gcctccatgc cctaggttgg gcccctgggg gatctgaggg 3360 cctgtggccc coagggcaag ttcccagatc ctatgtctgt ctgtccacca cgagatggga 3420 ggaggagaaa aagcggtacg atgccttcct gacctcaccg gcctccccaa gggtgccggc 3480 actctgggtg gactcacggc tgctgggccc cacgtcaaag gtcaagtgag acgtaggtca 3540 agtcctacgt cggggcccag acatcotggg gtcctggtct gtcagacagg ctgccctaga 3600 gccccaccca gtccgggggg actgggagca gttccaagac caccccaccc ctttttgtaa 3660 atcttgttca ttgtaaatca aatacagcgt ctttttcact ccgaaaaaaa aaaaaaaaaa 3720 aaaaaa 3726 <270> 171 <211 >2255

<212> DNA <213> Homo sapiens <400> 171 gatgtgggca cgcctcagag ccagaagttt atggotcoca cctgctcaat ctgacaggaa 60 gcttctgctc cccagttctc cccagccact gtggtctaca gattccagga aacccatccc 120 cctgtgacct cagggtgtgc tctgttctcc accctaggga ccagaaggag ocaggagtaa 180 agaactggct tacttggccg ccactgggaa attctgggta attcgagacg occtggaatt 240 tggacccact ccgotgatag gtggtgggca gggttctagg gaacacaaga ggcggagcca 300 ggtggcttcc ctgtgctggc attcttggct otctototct ctctttctct ctctctgtct 360 ctototctot ctctgtctct cagccttgaa gccgtttccc tctgcgattc atgtaagtgt 420 gactcgattt cagggaaagg gaactcgcgt gggctgagga gaccggagtg gacgggctgg 480 ggaaggcacc gtgatgcccg caaccccgtc cctgaaggtg gtccatgagc tgcctgcctg 540 taccctctgt gcggggccgc tggaggatgc ggtgaccgtt occtgtggac acaccttctg 600 ccggctctgc ctccccgcgc tctcccagat gggggcccaa tcctcgggca agatcctgct 660 ctgcccgctc tgccaagagg aggagcaggc agagaotccc atggcccctg tgcccctggg 720 cccgctggga gaaacttact gcgaggagca cggcgagaag atctacttct tctgcgagaa 780 cgatgccgag ttcctctgtg tgttctgcag ggagggtccc acgcaccagg cgcacaccgt 840 ggggttcctg gacgaggcca ttcagcccta ccgggatcgt ctcaggagtc gactggaagc 900 tctgagcacg gagagagatg agattgagga tgtaaagtgt caagaagacc agaagcttca 960 agtgctgctg actcagatcg aaagcaagaa gcatcaggtg gaaacagctt ttgagaggct 1020 gcagcaggag ctggagcagc agcgatgtct cctgctggcc aggctgaggg agctggagca 1080 gcagatttgg aaggagaggg atgaatatat cacaaaggtc tctgaggaag tcacccggct 1140 tggagcccag gtcaaggagc tggaggagaa gtgtcagcag ccagcaagtg agctictaca 1200 agatgtcaga gtcaaccaga goaggtgtga gatgaagact tttgtgagtc ctgaggccat 1260 ttctcctgac cttgtcaaga agatccgtga tttocaoagg aaaatactca ccctcccaga 1320 gatgatgagg atgttctcag aaaacttggc gcatcatctg gaaatagatt caggggtcat 1380 caotctggao cctcagaccg coagccggag cctggttctc tcggaagaca ggaagtcagt 1440 gaggtacacc cggcagaaga agagcctgcc agacagcccc ctgcgcttcg acggcctccc 1500 ggcggttctg ggcttoccgg gcttctcotc cgggcgccac ogctggcagg ttgacctgca 1560 gctgggcgac ggcggcggct gcacggtggg ggtggccggg gagggggtga ggaggaaggg 1620 agagatggga ctoagcgccg aggacggcgt ctgggccgtg atcatctcgc accagcagtg 1680 ctgggccagc acctccccgg gcaccgacct gccgctgago gagatcccgc gcggcgtgag 1740 agtcgccctg gactacgagg cggggcaggt gaccctccac aacgcccaga cccaggagcc 1800 catcttcacc ttcactgcct ctttctccgg caaagtcttc cctttctttg ccgtctggaa 1860 aaaaggttcc tgccttacgc tgaaaggctg aagtggggcg cgcgaagggc ggcgaagcgg 1920 agacggcggc tctccgggat ccagctccgc ccctggccag tgtgcggccc gggggctccc 1980 tgtgcccgcg tgaggcgaga gaacagggga cttgagtctc gaacagcggt tgtttttact 2040 ttatttatct taggccctca gctccctgac gtcctgagcc tccctgtgac gctctggcct 2100 tctctgcacc tcagagtgca gaaccacaga cggcttoggc tgtgcctagg gcaacagcca 2160 acctaggagc cagcgggctt tcggggaaaa aaaagaaaaa gacatctaaa ataaaatgtt 2220 taaactgttt caaaataaaa aaaaaaaaaa aaaaa 2255 <210> 172 <211> 942

<212> DNA <213> Homo sapiens <400> 172 tttatacatt ctaaatctcc ccagtttctt tggggctgga agatgoaact tccatttaat 60 agaaactttg aaatcttggg gtaagggagc agtgggggga ctagggagaa ggataagaaa 120 tagaattatt gaaaagcccc caccagggac cttcctggcc agaatatgca gagtaattcc 180 tgctggcttc acctttgaaa gtccctcgaa actatgcaga tgaaactgag tctgtttttg 240 atattpca“g“atgtattcta‘ccttggaagt'cccaacacct'aaactggaat tcttgtattt 300 acatctcctc cactgtcccc cacacoaccc ctcaattcct gctgcccotg ctaatgttaa 360 gcatttttct cttgttatca tcaggttcac attaaaaaca gatacttaca aactgacttg 420 aagcacagat acttttacga atgtgataaa atattttctt aagaaaagga aagaggatgt 480 gggtcaaata aaacaccgca tggatgttga ttggtgaata ctggtgtaag aaaagggagc 540 tcaggaattt ttattactgt atttgtaaat gagtttgaag gaatttgtaa atgccactgg 600 tacattttta aggtgacaca tttgctcctt ataaagttat taaaaattac agggtaagct 660 taaatgacgt ttgcoagtag ttttaottta tataatcaat attgatattg ttgctgaact 720 atgtaaottt atgatgcatt tttcagtccc ttttcagagc aaatgctttt gcaatggtag 780 taatgtttag tttaaattga cttaataaat tattacctga gcaaaaaaaa aaaaaaaaaa 840 aaaaaaaaaa taaaaaaaaa aaaaaaaaaa aaaaaaaaaa taataaaaaa aaaaaaaaca 900 aacaaatcaa taaaacttaa acaaaaaaaa aataaaaaaa aa 942 <210> 173 <211 > 1070

<212> DNA <213> Homo sapiens <400> 173 gcagagatcg ccacatcgtc ggacaaggtc aaggacgggg gcggcgggaa cgagggctct 60 ccatgcccac cgtgtcccgg gcccatagcc gggcaagccc taggaggcag ccgggcgtcg 120 ccggocccgg cgccgtcacg ctcgccctog gogcagtgtc cttttccagg cgggacggtg 180 ctgtcccggc ctctctacta caccgcgccc ttctatcccg gctacacgaa ctatggctcc 240 ttcggacacc ttcatggcca cccggggcog gggccgggcc ccacacccgg tccggggtct 300 catttcaatg gattaaacca gaccgtgttg aacogagcgg acgctttggc taaagacccg 360 aaaatgttgc ggagccagtc tcagctagac ctgtgcaaag actctcccta tgaattgaag 420 aaaggtatgt ccgacattta acgcgggctg cgtcggtccc ggacttttot aatttattaa 480 aaaoatggcc ttggcagtta tttttccatc accgagagag agagacagag agagaaaata 540 aactacccct cctattcaga agtttatagt ttatggagat ggatgacata aaaatgtaaa 600 catctccaca cacacaaaaa aatgtcttaa ccaaccgaaa agaaaaatta aaaaaggatt 660 •tgtattaaat cttattctgt atatttaatg tagcattttt gtatttaaat tgataattca 720 atatctttga agtaaattat gaaatcaaga cacctgtaca ggcatttaat gtttttttgt 780 aatataaata tatacatttg tgtttccccc aaaactgttt catagttaaa aaatacaagt 840 ttaatttaat tttttacacc tattgattct gctgggtatg agctaaagta ttacggaaag 900 gaaacaggtt atactcttag atttaaaaag tgaaagaaac tgcaggcgcc tttgtaaaat 960 gcaaaatatt taattaaaag agattttaac ataatgagag ccactcatta ctttttagaa 1020 gcctcaataa actgtccatt gccttggtca aaaaaaaaaa aaaaaaaaaa 1070 <210> 174 <211 > 668

<212> DNA <213> Homo sapiens <220> <221 > misc_feature <222> (60)..(60) <223> a or g or c or t/u <400> 174 atatccaaga aatttggaca cctataccta cagaataatg aaatagaaaa gatgaatctn 60 acagtgatgt gtccttctat tgacccacta cattaccacc atttaacata cattcgtgtg 120 gaccaaaata aactaaaaga accaataagc tcatacatct tcttctgctt ccctcatata 180 cacactattt attatggtga acaacgaagc actaatggtc aaacaataoa actaaagacc 240 caagttttca ggagatttcc agatgatgat gatgaaagtg aagatoacga tgatcctgac 300 aatgctcatg agagcccaga acaagaagga gcagaagggc actttgacct tcattattat 360 gaaaatcaag aafagcaaga-aactatatag~gtatacactracgacttcaiTaaaacctata 420 cttaatatag taaatctaag taaacatgta ttaotcaaag taatatattt agaattatgt 480 attagtataa gatcagaatt gaatttaagt tgttggtgac atctgcatca tttcatagga 540 ttagaactta ctcaaaataa tgtaaatctt taaaaatata aattagaatg acaagtggga 600 atcataaatt aaacgttaat ggtttcttat gctcttttta aatatagaaa tatcatgtta 660 aaaaaaaa 668 <210> 175 <211 >2953

<212> DNA <213> Homo sapiens <400> 175 atgattgcaa cagtggattt aaaagtoaat gaatatgaga aaaaccaaaa atggcttgag 60 atcctaaata agattgaaaa caaaacatac acgaagctca aaaatggaca tgtgtttagg 120 aagcaggcac tgatgagtga agaaaggact ctgttatatg atggccttgt ttactggaaa 180 actgctacag gtcgtttcaa agatatccta gctctaottc taactgatgt gctgctcttt 240 ttacaagaaa aagaocagaa atacatcttt gcagccgttg atcagaagcc atcagttatt 300 tcccttcaaa agottattgc tagagaagtt gctaatgagg agagaggaat gtttctgatc 360 agtgcttcat ctgctggtcc tgagatgtat gaaattcaca ccaattccaa ggaggaacgc 420 aataactgga tgagacggat ccagcaggct gtagaaagtt gtcctgaaga aaaaggggga 480 aggacaagtg aatctgatga agacaagagg aaagctgaag ccagagtggc caaaattcag 540 caatgtcaag aaatactcac taaccaagac caacaaattt gtgcgtattt ggaggagaag 600 ctgcatatct atgctgaact tggagaactg agoggatttg aggacgtcca tctagagccc 660 cacctcctta ttaaacctga cccaggcgag cctccccagg cagcctcatt actggcagca 720 gcactgaaag aagcattagt cacaggaggg agagaaggaa gaggotgttc ggatgtggat 780 cccgggatcc agggtgtggt aaocgacttg gccgtotctg atgcagggga gaaggtggaa 840 tgtagaaatt ttccaggtto ttcacaatca gagattatao aagocataoa gaatttaacc 900 cgtctcttat acagcottoa ggccgccttg accattcagg acagcoacat tgagatccac 960 aggctggttc tocagcagca ggagggcctg tctctcggcc actctatcct ccgaggcggc 1020 cccttgcagg accagaagtc tcgcgacgcg gacaggcagc atgaggagct ggooaatgtg 1080 caccagcttc agcaocagot ccagcagggg cagcggcgct ggctgcgcag gtgtgagcag 1140 cagcagcggg cgcaggcgac oagggagagc tggctgoagg agcgggagcg ggagtgccag 1200 tcgcaggagg agctgctgct gcggagccgg ggcgagctgg acctccagct ccaggagtac 1260 cagcacagcc tggagcggct gagggagggo cagcgcctgg tggagaggga gcaggcgagg 1320 atgcgggccc agcagagcct gctgggccac tggaagcacg gccggcagag gagcctgtcc 1380 gcggtgctcc ttccgggtgg ccccgaggta atggaactta atcgatctga gagtttatgt 1440 catgaaaact cattcttoat caatgaagct ttagtacaaa tgtcatttaa cactttcaac 1500 aaactgaatc catcagttat ccatcaggat gccacttacc ctacaactca atctcattct 1560 gacttggtga ggactagtga acatcaagta gacctcaagg tggacccttc tcagccttcg 1620 aatgtcagtc acaaactgtg gacagccgct ggttccggcc atcagatact tcctttccat 1680 gaaagcagca aggattcttg taaaaatggc tccagtatga caaagtgcag ttgtacgttg 1740 acatctcccc cgggactgtg gactggaacc acatctactt tgaaggattt ggacacctcc 1800 cacactgagt ccocaaccoc ocatgactca aattcacacc gccctcaact gcaggcgttt 1860 ataacagaag caaagctaaa tctaccgaca aggacaatga ccagacaaga tggggaaact 1920 ggagatggag ccaaagaaaa tattgtttac ctctaattgt gttgtcattt ttccaaacaa 1980 aacaaaacac tggcactttt gggagaaact ttttgtctcc attccttatg tatgtgtgat 2040 tgtctgtgtc caaattgctt taagaataat atttaatatt tcctggaagc tcattttttt 2100 ggcatgagtc taattaaatt attgaaagcc accctgtttg tataatottt aacttatcaa 2160 atctaatttc agatttctgg aggagaaact aacttgaata agcaggacta ttttaaaagt 2220 tgttttgacg ctagagtaaa attccatgtc acattttcta cccaatcato tggatttcaa 2280 gattcctttt aagatctcaa tgaagcaatt tggatttaaa gagtggtatt cacaaggggt 2340 gaactttcac agtcagggoa gttgcctcag tgcccacata ggcagaggag gatgtgggaa 2400 agggottttc tcagctagtt tttgtgtgot catttcttct gggagcatta aaagtggtga 2460 tctgttacag tcactattca actgggcacg tgttgtgatt ggtcagtcac tgagocaggg 2520 aSc^tccg_gactt"gcttigtacctaa“gc“cta'atgcfgg~tggggtttc'a_agauatggtf-2580------------- cagcatcatc ttttaacaag gcccagaggc ccagagcccg catcaagtca ttttgatgta 2640 aatagtgaac tttgttagag ccctcactto tatcaatcag ctgtcctgtc cctgccagca 2700 cctggagcac caactaccac tccctggaaa gaacccttcc ctgcagtttt ttaaggacaa 2760 aactgcccac tcctcattaa gtttgctgcc tggatacact tttccaoaaa ggaaaactgg 2820 catatcctgc cttccgagta gtatgggtct ctgtgtgaga aaccaggaga tattttcatc 2880 ttgttcggaa atacttgtat gtattttggt gtcaataaat atcttgtacc tcattaaaaa 2940 aaaaaaaaaa aaa 2953 <210> 176 <211> 4157

<212> DNA <213> Homo sapiens <400> 176 ctgagccgca tctgcaatag cacacttgcc cggccacctg ctgccgtgag cctttgctgc 60 tgaagcccct ggggtcgcct ctacctgatg aggatgtgca cccccattag ggggctgctc 120 atggcccttg cagtgatgtt tgggacagcg atggcatttg cacccatacc ccggatcacc 180 tgggagcaca gagaggtgca cctggtgcag tttcatgagc cagacatcta caactactca 240 gccttgctgc tgagcgagga caaggacacc ttgtacatag gtgcccggga ggoggtcttc 300 gctgtgaacg cactoaacat ctccgagaag cagcatgagg tgtattggaa ggtctcagaa 360 gacaaaaaag caaaatgtgc agaaaagggg aaatcaaaac agacagagtg cctcaactac 420 atccgggtgc tgcagccact cagcgcoact tccctttacg tgtgtgggac caacgcattc 480 cagccggcct gtgaccacct gaacttaaoa tcctttaagt ttctggggaa aaatgaagat 540 ggcaaaggaa gatgtccott tgaccoagca cacagctaca catccgtcat ggttgatgga 600 gaactttatt cggggacgtc gtataatttt ttgggaagtg aacccatcat ctcccgaaat 660 tcttcccaca gtcctctgag gacagaatat gcaatccctt ggctgaacga gcctagtttc 720 gtgtttgctg acgtgatccg aaaaagccca gacagccccg acggcgagga tgacagggtc 780 tacttcttct tcacggaggt gtctgtggag tatgagtttg tgttcagggt gctgatcoca 840 cggatagcaa gagtgtgcaa gggggaccag ggcggcctga ggaccttgca gaagaaatgg 900 acctccttcc tgaaagcccg actcatctgc tcccggccag acagcggctt ggtcttcaat 960 gtgctgcggg atgtcttcgt gctcaggtcc ccgggcctga aggtgcctgt gttctatgca 1020 ctcttcaccc cacagctgaa caacgtgggg ctgtcggcag tgtgcgccta caacctgtcc 1080 aoagccgagg aggtcttctc ccacgggaag tacatgcaga gcaccacagt ggagcagtcc 1140 cacaccaagt gggtgcgcta taatggcccg gtacccaagc cgcggcctgg agcgtgcatc 1200 gacagcgagg cacgggccgc caactacacc agotccttga atttgccaga caagacgctg 1260 cagttcgtta aagaccaccc tttgatggat gactcggtaa ccccaataga caacaggccc 1320 aggttaatca agaaagatgt gaactacacc cagatcgtgg tggaccggac ccaggccctg 1380 gatgggactg tctatgatgt catgtttgtc agcacagacc ggggagctct gcacaaagcc 1440 atcagcctcg agcacgctgt tcacatcatc gaggagaccc agctcttcca ggactttgag 1500 ccagtccaga ccctgctgct gtcttcaaag aagggcaaoa ggtttgtcta tgctggctct 1560 aactcgggcg tggtccaggc cccgctggcc ttctgtggga agcacggcac ctgcgaggac 1620 tgtgtgctgg cgcgggaccc ctactgcgcc tggagcccgc ccacagcgac ctgcgtggct 1680 ctgcaccaga ccgagagccc cagcaggggt ttgattcagg agatgagcgg cgatgcttct 1740 gtgtgcccgg ataaaagtaa aggaagttac cggcagcatt ttttoaagca cggtggcaoa 1800 gcggaactga aatgctccca aaaatccaac ctggcccggg tcttttggaa gttccagaat 1860 ggcgtgttga aggccgagag ccccaagtac ggtcttatgg gcagaaaaaa cttgctcatc 1920 ttcaacttgt cagaaggaga cagtggggtg taooagtgcc tgtcagagga gagggttaag 1980 aacaaaacgg tottocaagt ggtcgccaag cacgtcctgg aagtgaaggt ggttocaaag 2040 cccgtagtgg cccccacctt gtcagttgtt cagacagaag gtagtaggat tgccaooaaa 2100 gtgttggtgg catccaccca agggtcttct cccccaaccc cagccgtgca ggccacctcc 2160 tccggggcoa tcacccttco tcccaagcct gcgcccaccg gcacatcctg cgaaccaaag 2220 atcgtcatca acacggtccc ccagctccac tcggagaaaa ccatgtatct taagtccagc 2280 gacaaccgcc tectcatgto cctcttcctc ttcttctttg ttctcttcct ctgcctcttt 2340 ttctacaact gctataaggg atacctgccc agacagtgct tgaaattccg ctcggcccta 2400 "ciaattggga agaagaagcc cFa^cagarftctgtgaciTgtpgcagag cctgaaggifg- 2460 acgttagtag agccagggag cttcteccag cagaatgggg agcaccccaa gecagccctg 2520 gacaccggct atgagaccga gcaagacacc atcaccagca aagtccccac ggatagggag 2580 gactcacaga ggatcgacga cctttctgcc agggacaagc cctttgacgt caagtgtgag 2640 ctgaagttcg ctgactcaga ogcagatgga gactgaggcc ggctgtgcat ccccgctggt 2700 gcctcggctg cgacgtgtcc aggcgtggag agttttgtgt ttctcctgtt cagtatccga 2760 gtctcgtgca gtgotgcgta ggttagcccg catcgtgcag acaacctcag tcctcttgto 2820 tattttctot tgggttgagc ctgtgacttg gtttctcttt gtccttttgg aaaaatgaca 2880 agcattgcat cccagtottg tgttccgaag tcagtcggag tacttgaaga aggcccacgg 2940 goggcacgga gttcctgagc cctttctgta gtgggggaaa ggtggctgga cctctgttgg 3000 otgagaagag catcccttca gcttcccctc ccogtagcag ccactaaaag attatttaat 3060 tccagattgg aaatgacatt ttagtttatc agattggtaa cttatcgcct gttgtccaga 3120 ttggcacgaa ccttttcttc cacttaatta tttttttagg attttgcttt gattgtgttt 3180 atgtcatggg tcattttttt ttagttacag aagcagttgt gttaatattt agaagaagat 3240 gtatatcttc cagattttgt tatatatttg gcataaaata cggcttacgt tgcttaagat 3300 tctcagggat aaacttcctt ttgctaaatg cattctttct gcttttagaa atgtagacat 3360 aaacactcco cggagcccac tcaccttttt tctttttctt tttttttttt taactttatt 3420 ccttgaggga agcattgttt ttggagagat tttctttctg tacttcgttt tacttttctt 3480 tttttttaac ttttactctc tcgaagaaga ggaocttccc acatccacga ggtgggtttt 3540 gagcaaggga aggtagcctg gatgagctga gtggagccag gctggcccag agctgagatg 3600 ggagtgcggt acaatctgga gcccacagct gtcggtcaga acctcctgtg agacagatgg 3660 aaccttcaca agggcgcctt tggttotctg aacatctoct ttctcttctt gcttoaattg 3720 cttacocact gcctgcocag actttctatc cagcctoact gagotgocca ctaotggaag 3780 ggaactgggc ctcggtggcc ggggccgoga gctgtgacca oagcaocctc aagcatacgg 3840 cgctgttcct gccactgtcc tgaagatgtg aatgggtggt acgatttoaa cactggttaa 3900 tttcacactc catctcoccg ctttgtaaat acccatcggg aagagacttt ttttccatgg 3960 tgaagagcaa taaaotctgg atgtttgtgc gcgtgtgtgg acagtcttat cttccagcat 4020 gataggattt gaccattttg gtgtaaacat ttgtgtttta taagatttac cttgttttta 4080 tttttctact ttgaattgta tacatttgga aagtacccaa ataaatgaga agcttctatc 4140 cttaaaaaaa aaaaaaa 4157 <210> 177 <211> 1023

<212> DNA <213> Homo sapiens <220> <221 > misc_feature <222> (4)..(4) <223> a or g or c or t/u <220> <221 > misc_feature <222> (23)..(23) <223> a or g or c or t/u <220> <221 > misc_feature <222> (28)..(28) <223> a or g or c or t/u <220> <221 > misc_feature <222> (47)..(47) <223> a or g or c or t/u <220> <221 > misc_feature <222> (53)..(53) <223> a or g or c or t/u <220> <221 > misc_feature <222> (69)..(69) <223> a or g or c or t/u <400> 177 cccntcccca gaggcaggaa aancagtntg ccgaaaggat agactgnggt gcngtctttc 60 cccaagttnt gaactagttt taaggtagct taggatgaaa aatggagaat gattgggggt 120 tccaaaccac tttcttotcc cttggcttat atctcttcac catttggtgg tcaactgtgg 180 gcctaccctg gacctcatct actoagcgag aattggacat gaagctagag gcagctgcct 240 tggaagggaa gtcaggctca cttggacagc ccaggccatg gcaggaagaa tcccttcctc 300 ttggggtcct tgatgggcat gtgtgatggg gaaggagcag tctoccagcc ctgggtctgc 360 tccccacatc tctcctaatt ccacttcacc ttttgccacc ccctccccac cagaggccta 420 gcccttttgt caccgaaggc ccccagagtg tttctgtgtg aaaccctctc atttacactg 480 tggcatcaaa atccaoaaaa gatggattaa ttgcactctg gttaatagca gcagcacaat 540 gattaaaatc tatattccta tcttctctag caccctggtg tggggatggg gcggaagggt 600 gtcttgaggg gcagggagga ccccataaaa caatccctcc tgcattctca ggctaaatag 660 ggcccccagt gactacctgt tcttggctgt cccctotgaa gagctctgcc ttctcacagc 720 caocaccagt tgcocoacto ocaggaaaac agcacatgtt ottcttctcc tgoottgaga 780 ctgcgtgtta gtcttccatt oataactoat cagcagotoa gtccttctta tgtetagtct 840 cagttcattc agccaaagot catttttgtc ctatccaaag tagaaagggt tcttttagaa 900 aacttgaaga atgtgcctcc tcttagcatc tgtttotgac tcccagttat ttttaaaata 960 aatgatgaat aaaatgcctg ccctgaaggg ttctggagga gtcaggtatc aaaaaaaaaa 1020 aaa 1023 <210> 178 <211> 550

<212> DNA <213> Homo sapiens <400> 178 tttttaagat gatcttgctc cgtcacccag gctggagtgc agtggcgtaa tcatggcttc 60 ctgcagcctc aaactcctgg gctcaatgag ttccttgaga tcttccatcc tcagcttccc 120 aagtagctag tagtagtagt ggcttgcacc aacgctcctg ccctaatttt caatattttt 180 tttgtagaga taggatctca ctgtgttacc caagotagac ttgaactcct ggcctcaagc 240 gatccttccg ccttggcctc ocaaagtgtt gggattacag gcattagcta ccacacctgg 300 ccaaggccca ggtttcgaca gaaagggaga gaaaacctgc cagagatgcc atttcggagc 360 cactctgctt ggcagggacc tgtgttcccc tcatgcaggt tcatccttag agggctgcgg 420 tcttatctgg ttgtgcaaaa gtcccacaac ctttctggat tgatagtttg tggtgaaata 480 aacaatttta gtttgtttgg agaatctttt gtatacaaaa tacaaataaa acctaaatca 540 aagaaacaga 550 <210> 179 <211 >2798

<212> DNA <213> Homo sapiens <400> 179 gaggggccgg aggcgtcccc gctoccgotc gctactagcc cgcgggccag cgccgcgtcc 60 —cgagccccgg-cgggagccatrggctctaaaa ggacaagaagattatattta~tcttttcaag—120---------- gattcaacac atccagtgga ttttctggat gcattcagaa cattttactt ggatggatta 180 tttactgata ttactcttca gtgtccttca ggoataattt tccattgtca oogagocgtt 240 ttagctgctt gcagcaatta ttttaaggca atgttcacag ctgaoatgaa agaaaaattt 300 aaaaataaaa taaaactcto tggcatcoac catgatattc tggaaggcct tgtaaattat 360 gcatacactt cccaaattga aataactaaa agaaatgttc aaagcctgct tgaggcagog 420 gatctgctac agttcctttc agtaaagaag gcttgtgagc ggtttttggt aaggcacttg 480 gatattgata attgtattgg aatgcactcc tttgcagaat ttoatgtgtg tocagaacta 540 gagaaggaat ctcgaagaat tctatgttca aagtttaagg aagtgtggca acaagaagaa 600 tttctggaaa tcagccttga aaagtttctc tttatcttgt ccagaaagaa tctcagtgtt 660 tggaaagaag aagctatcat agagccagtt attaagtgga ctgctcatga tgtagaaaat 720 cgaattgaat goctctataa tctactgagc tatatoaaca ttgatataga tccagtgtac 780 ttaaaaacag octtaggcct tcaaagaagc tgcctgctca ccgaaaataa gatccgctcc 840 ctaatataca atgccttgaa tcccatgcat aaagagattt cccagaggtc cacagccaca 900 atgtatataa ttggaggcta ttactggcat cctttatcag aggttcacat atgggatcct 960 ttgacaaatg tttggattca gggagcagaa ataccagatt ataccaggga gagctatggt 1020 gttacatgtt taggacccaa catttatgta actgggggct acaggacgga taacatagaa 1080 gctcttgaca cagtgtggat ctataacagt gaaagtgatg aatggacaga aggtttgcca 1140 atgctcaatg ccaggtatta ccactgtgca gtcaccttgg gtggctgtgt ctatgcttta 1200 ggtggttaca gaaaaggggc tccagcagaa gaggctgagt tctatgatcc tttaaaagag 1260 aaatggattc ctattgcaaa catgattaaa ggtgtgggaa atgctactgc ctgtgtctta 1320 catgatgtta tctacgtcat tggtggccac tgtggctaca gaggaagctg cacctatgac 1380 aaagttcaga gctacaattc cgatateaac gaatggagcc tcatcacctc cagtcoacat 1440 ccagaatatg gattgtgctc agttccgttt gaaaataagc tctatotagt cggtggacaa 1500 actacaatca cagaatgcta tgaccctgaa caaaatgaat ggagagagat agctcccatg 1560 atggaaagga ggatggagtg cggtgccgtc atcatgaatg gatgtattta tgtcaotgga 1620 ggatactcct actcaaaggg aacgtatctt cagagcattg agaaatatga tccagatctt 1680 aataagtggg aaatagtggg taatcttccc agtgccatgc ggtctcatgg gtgtgtttgt 1740 gtgtataatg tctaattgaa tctgcagaaa tgaccaagca atcacttttt tggagtatag 1800 ttttataaaa aaagaatgca gggtttgaag ttccttacct gataattgtg tctggcacat 1860 gataggggat cagtaaattg taattoctaa ccctactgta ctcccaaaca tggtgattca 1920 tggtoaagaa aaatcttata tatatatata cacacacata tatatgtgtt catatatatg 1980 tatacatata tgtgtatata tacgcatgta tgtatacata tatgtgtata tatacgcatg 2040 tatgtatgca tatgtgtgta tatatacgta tgtatgtata catatgtgta tatataogta 2100 tgtatgtata catatatgtg tatatatgcg tatgtatgta tacatatatg tgtatatata 2160 cgtatgtatg tatacatata tgtgtatata tacgtatgta tgtatacata tatgtgtata 2220 tatacgtatg tatgtataca tatatgtgtg tatatacgtg tgtatgtata catatatgtg 2280 tatatatacg tgtgtatgta tacatatatg tgtatatatg cgtgtgtatg tatacatata 2340 tgtgtatata tacgtgtgta tgtatacata tatgtgtata tatacgtgtg tatgtataca 2400 tatatgtgta tatatgcgtg tgtatatata tacacatata tacgtatata tgtatatata 2460 tatacacagt tgaatcagtg ggattaatac ctataatctc tggttttcaa aggtaatatg 2520 gaatatttga cacttggtaa aaggtgaact acctttgtag tgaatctttt cctcttggta 2580 gcatcaacac tggggataaa tcagaaccat tctgtggaat gaaatgtttc tcaagagcct 2640 ataatatagt agatagtgca tattaagatg tctggctggg catggtggct catgcctgta 2700 atcccagcac tttgggaggc tgaggcggga ggatcacttg agcctagaag ttggagacta 2760 acctggcgag accctgtctc aaaaaaaaaa aaaaaaaa 2798 <210> 180 <211 > 439

<212> DNA <213> Homo sapiens <400> 180 acccttttgt gaccagctgc ataccccaaa accttttgga atctgggcta actggctgtg 60 cctacatcaa cagcacccgt gaacccccgt gtgctatgct ctgtgcaaca aaacattcag 120 —aacccacttt-caagatgctg~ctgctgtgcc“agtgtgacaa-aaaaaagagg“cgcaagcagc—180——~ agtaccagca gagacagtcg gtcatttttc acaagcgcgc acccgagcag gccttgtaga 240 atgaggttgt atcaatagca gtgacaaaac gcacacatca acccacagac cttaggagga 300 ggaaggcgag ggcggggtga cttctggtga tgataaaaat ggttttatca cccagatgtg 360 aaagaagctg cctgtttact gatccattga ataaacccat tttaatagaa aaagtcaata 420 ccaattcagc aaaaaaaaa 439 <210> 181 <211 > 1309

<212> DNA <213> Homo sapiens <400> 181 tatctatgta acaaatcgca gcacaggagt cocctgggct ccctcaggct ctggtatgac 60 atatttgagc catataaatt cagcttctcc tctggcatct gttagccgac tcacttgcaa 120 ctccacctca gcagtggtct ctcagtcctc tcaaagcaag gaaagagtac tgtgtgctga 180 gagaccatgg caaagaatcc tcoagagaat tgtgaagact gtcacattct aaatgcagaa 240 gcttttaaat ccaagaaaat atgtaaatca cttaagattt gtggactggt gtttggtatc 300 ctgaccctaa ctctaattgt cctgttttgg gggagcaagc acttctggcc ggaggtaccc 360 aaaaaagoct atgacatgga goacaotttc tacagcagtg gagagaagaa gaagatttac 420 atggaaattg atcctgtgac cagaactgaa atattcagaa gcggaaatgg caotgatgaa 480 acattggaag tacacgactt taaaaacgga tacactggca tctacttcgt gggtcttcaa 540 aaatgtttta tcaaaactca gattaaagtg attoctgaat tttctgaacc agaagaggaa 600 atagatgaga atgaagaaat taccacaact ttctttgaac agtcagtgat ttgggtccca 660 gcagaaaagc otattgaaaa ccgagatttt cttaaaaatt ccaaaattct ggagatttgt 720 gataacgtga ccatgtattg gatcaatccc actctaatat cagtttctga gttacaagac 780 tttgaggagg agggagaaga tottcaottt cctgccaacg aaaaaaaagg gattgaacaa 840 aatgaacagt gggtggtccc tcaagtgaaa gtagagaaga cocgtcacgc cagacaagca 900 agtgaggaag aacttccaat aaatgactat actgaaaatg gaatagaatt tgatcccatg 960 ctggatgaga gaggttattg ttgtatttac tgccgtcgag gcaaccgcta ttgcogccgc 1020 gtetgtgaac ctttactagg ctactaccca tatccatact gctaccaagg aggacgagtc 1080 atctgtcgtg tcatcatgco ttgtaaotgg tgggtggccc gcatgctggg gagggtctaa .1140 taggaggttt gagctcaaat gcttaaactg ctggcaaoat ataataaatg catgctattc 1200 aatgaatttc tgcctatgag gcatctggcc cctggtagcc agctctccag aattacttgt 1260 aggtaattcc tctcttcatg ttctaataaa cttctacatt atcaaaaaa 1309 <210> 182 <211> 1477

<212> DNA <213> Homo sapiens <400> 182 gcggategct gctccctctc gccatggcgc aggtgctgat cgtgggcgcc gggatgacag 60 gaagcttgtg cgctgcgctg ctgaggagge agacgtccgg tcccttgtac cttgctgtgt 120 gggacaaggc tgacgactca gggggaagaa tgactacagc ctgcagtcct cataatcctc 180 agtgcacagc tgacttgggt gctcagtaca tcacctgcac tcctcattat gccaaaaaac 240 accaacgttt ttatgatgaa ctgttagcct atggcgtttt gaggcctcta agctcgccta 300 ttgaaggaat ggtgatgaaa gaaggagact gtaactttgt ggcacctcaa ggaatttctt 360 caattattaa gcattacttg aaagaatcag gtgcagaagt ctacttcaga oatogtgtga 420 cacagatcaa cclaagagat gacaaatggg aagtatccaa acaaacaggc tcccctgagc 480 agtttgatct tattgttctc acaatgccag ttcctgagat tctgcagctt caaggtgaca 540 toaccaoctt aattagtgaa tgccaaaggo agcaactgga ggotgtgagc tactcctctc 600 gatatgctct gggcctcttt tatgaagctg gtacgaagat tgatgtccct tgggctgggo 660 agtacatcac cagtaatccc tgcatacgct tcgtctccat tgataataag aagcgcaata 720 tagagtcatc agaaattggg ccttccctcg tgattcacac cactgtccca tttggagtta 780 catacttgp_a'cac"agcatt'gaggatgtgc“aa‘ga'gttagrcttccag"cag ctggaaaaca—840------ ttttgccggg tttgcctcag ccaattgcta ccaaatgcca aaaatggaga cattcacagg 900 ttacaaatgc tgctgccaac tgtcctggcc aaatgactct gcatcacaaa cctttccttg 960 catgtggagg ggatggattt actcagtcca actttgatgg ctgcatcact tctgccctat 1020 gtgttctgga agctttaaag aattatattt agtgcctata tccttattct ctatatgtgt 1080 attgggtttt tattttcaca attttctgtt attgattatt ttgttttcta ttttgctaag 1140 aaaaattact ggaaaattgt tcttcactta ttatoatttt tcatgtggag tataaaatca 1200 attttgtaat tttgatagtt acaacocatg ctagaatgga aattcctcac aocttgcacc 1260 ttccctactt ttctgaattg ctatgactac tocttgttgg aggaaaagtg gtacttaaaa 1320 aataacaaac gactctctca aaaaaattac attaaatcac aataacagtt tgtatgooaa 1380 aaacttgatt atccttatga aaatttcaat tctgaataaa gaataatcac attateaaag 1440 ccccatcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 1477 <210> 183 <211> 3100

<212> DNA <213> Homo sapiens <400> 183 actcgtctct ggtaaagtot gagcaggaca gggtggctga ctggcagatc cagaggttcc 60 cttggcagtc cacgccaggc cttcaccatg gatcagttcc ctgaatoagt gacagaaaac 120 tttgagtacg atgatttggc tgaggcctgt tatattgggg acatcgtggt ctttgggact 180 gtgttcctgt ccatattcta ctccgtcatc tttgccattg gcctggtggg aaatttgttg 240 gtagtgtttg ccctcaccaa cagcaagaag cccaagagtg tcaccgacat ttacctcctg 300 aacctggcct tgtctgatct gctgtttgta gccactttgc ccttctggac tcactatttg 360 ataaatgaaa agggcctcoa caatgccatg tgcaaattca ctaccgcctt cttcttoatc 420 ggcttttttg gaagcatatt cttcatcacc gtcatcagca ttgataggta cctggccatc 480 gtcctggccg ccaactccat gaacaaccgg accgtgcagc atggogtcac oatcagccta 540 ggcgtctggg cagcagccat tttggtggca gcacoocagt tcatgttcac aaagcagaaa 600 gaaaatgaat gccttggtga ctaccocgag gtcctccagg aaatctggcc cgtgctccgc 660 • aatgtggaaa caaattttct tggcttccta ctccccctgc tcattatgag ttattgctac 720 ttcagaatca tccagacgct gttttcctgc aagaaccaca agaaagccaa agccattaaa 780 ctgatccttc tggtggtcat cgtgtttttc ctcttctgga caccctacaa cgttatgatt 840 ttcctggaga cgcttaagct ctatgacttc tttcccagtt gtgacatgag gaaggatctg 900 aggctggccc tcagtgtgac tgagacggtt gcatttagcc attgttgcct gaatcctctc 960 atctatgcat ttgctgggga gaagttcaga agataccttt accacctgta tgggaaatgc 1020 ctggctgtcc tgtgtgggcg ctcagtccac gttgatttct cctcatctga atcacaaagg 1080 agcaggcatg gaagtgttct gagcagoaat tttacttacc acacgagtga tggagatgoa 1140 ttgctccttc tctgaaggga atcccaaagc cttgtgtcta cagagaacct ggagttcctg 1200 aacctgatgc tgactagtga ggaaagattt ttgttgttat ttcttacagg cacaaaatga 1260 tggacccaat gcacacaaaa caaccctaga gtgttgttga gaattgtgct caaaatttga 1320 agaatgaaca aattgaactc tttgaatgac aaagagtaga catttctctt actgcaaatg 1380 tcatcagaac tttttggttt gcagatgaca aaaattoaac tcagactagt ttagttaaat 1440 gagggtggtg aatattgttc atattgtggc acaagcaaaa gggtgtctga gccctcaaag 1500 tgaggggaaa ccagggcctg agccaagcta gaattccctc tctotgacto tcaaatcttt 1560 tagtcattat agatccccca gactttacat gacacagctt tatcaccaga gagggactga 1620 cacccatgtt tctctggccc caagggaaaa ttcccaggga agtgctctga taggccaagt 1680 ttgtatcagg tgcccatccc tggaaggtgc tgttatccat ggggaaggga tatataagat 1740 ggaagcttcc agtccaatct catggagaag cagaaataca tatttccaag aagttggatg 1800 ggtgggtact attctgatta cacaaaacaa atgccacaca tcacccttac catgtgcctg 1860 atccagcctc tcccctgatt acaccagcct cgtcttcatt aagccctctt ccatcatgtc 1920 cccaaacctg caagggotcc ccactgccta ctgcatcgag tcaaaactca aatgcttggc 1980 ttctcatacg tccaccatgg ggtcctacca atagattccc cattgcctcc tccttcccaa 2040 aggactccac ccatcctatc agcctgtctc ttccatatga cctcatgcat otccacctgc 2100 tcccaggcca gtaagggaaa tagaaaaaco ctgcccccaa ataagaaggg atggattcca 2160 åccccaac'tcTTagtagctt'g'^gacaaatca agcttcagtttcctggtctg-tagaagaggg—2220- ataaggtacc tttcacatag agatcatcct ttccagcatg aggaactagc oacoaactot 2280 tgcaggtctc aacccttttg tctgcctctt agacttctgc tttccacacc tgcactgctg 2340 tgctgtgccc aagttgtggt gctgacaaag cttggaagag cctgcaggtg ccttggccgc 2400 gtgcatagcc cagacacaga agaggctggt tcttacgatg gcacccagtg agcactccca 2460 agtctacaga gtgatagcct tccgtaaccc aactctcctg gactgccttg aatatcccct 2520 cccagtcacc ttgtgcaagc ccctgcccat ctgggaaaat accccatcat tcatgctact 2580 gccaacetgg ggagccaggg ctatgggagc agcttttttt tcccccctag aaacgtttgg 2640 aacaatgtaa aactttaaag ctcgaaaaca attgtaataa tgctaaagaa aaagtcatcc 2700 aatctaacca catcaatatt gtcattcctg tattcacccg tccagacctt gttcacacto 2760 tcacatgttt agagttgcaa tcgtaatgta cagatggttt tataatctga tttgttttcc 2820 tcnaacgtt agaccacaaa tagtgctcgc tttctatgta gtttggtaat tatcatttta 2880 gaagactcta ccagactgtg tattcattga agtcagatgt ggtaactgtt aaattgctgt 2940 gtatctgata gctctttggc agtctatatg tttgtataat gaatgagaga ataagtcatg 3000 ttccttcaag atcatgtacc ccaatttaot tgccattact caattgataa acatttaact 3060 tgtttccaat gtttagoaaa tacatatttt atagaacttc 3100 <210> 184 <211 > 662

<212> DNA <213> Homo sapiens <400> 184 tgaacatatt caggctgatt ggggacgtgt ccoacctggc ggccatcgtc atottgatgg 60 tagagatctg gaagacgcgc tcctgcgccg gtatttetgg gaaaagccag cttctgtctg 120 cactggtctt cacaactcgt gacotggatc ttttcacttc atttatttca gtgtatcaca 180 catctatcaa ggttatctac gttgoctgct cgtatgccac agtgtacctg atctacctta 240 aatttaaggc aacatcggat ggaaatcatg ataccttccg agtggagttt ctggtggtcc 300 ctgtgggagg cctcctcatt tttagttaat cacgatttct ctcctcttga gtactoaagg 360 gaaagaagct cagtttgcca gcataagtgc caaagaccat cgccagcatc tgtccttcag 420 ggtgttcgga cagaattctt accacagcaa aggcataaga tgcttgatac ggaaaatcaa 480 gaacttaact tttttgttgc agatagtcat cagtggttct gtaaaaaogc agaggaaaag 540 agccagaagg tttctgttta atgcatcttg ccttatcttt ttttattact gtgcacaaag 600 atttttttac acaaacatcc tfaatgctgt tttaataaat tcagtgtgta gcttcaaaaa 660 aa 662 <210> 185 <211>5920

<212> DNA <213> Homo sapiens <400> 185 ggcaggtctc gctctcggca ccctcccggc gcccgcgttc tcctggccct gcccggcatc 60 ccgatggccg ccgctgggcc ccggcgctcc gtgcgcggag ccgtctgcct gcatctgctg 120 ctgaccctcg tgatcttcag tcgtgatggt gaagcctgca aaaaggtgat acttaatgta 180 ccttctaaac tagaggcaga caaaataatt ggcagagtta atttggaaga gtgcttcagg 240 tctgcagacc tcatccggtc aagtgatcct gatttcagag ttctaaatga tgggtcagtg 300 tacacagcca gggctgttgc gctgtctgat aagaaaagat catttaccat atggctttct 360 gacaaaagga aacagacaca gaaagaggtt actgtgctgc tagaacatca gaagaaggta 420 tcgaagacaa gacacactag agaaactgtt ctcaggcgtg ccaagaggag atgggcacct 480 attccttgct ctatgcaaga gaattccttg ggccctttcc cattgtttct tcaacaagtt 540 gaatctgatg cagcacagaa ctatactgtc ttctactcaa taagtggacg tggagttgat 600 aaagaacctt taaatttgtt ttatatagaa agagacactg gaaatctatt ttgcactcgg 660 cctgtggatc gtgaagaata tgatgttttt gatttgattg cttatgcgtc aactgcagat 720 ggatattcag cagatctgcc cctcccacta cccatcaggg tagaggatga aaatgacaac 780 cacwtgttirtca:cag'aag'c_aatttataattttga'agtt1rtggaaagtag-tagacctggt—840--- actacagtgg gggtggtttg tgccacagac agagatgaac cggacacaat gcatacgcgc 900 ctgaaataca gcattttgca gcagacacca aggtcacctg ggctcttttc tgtgcatccc 960 agcacaggcg taatcaccac agtctctcat tatttggaca gagaggttgt agacaagtac 1020 tcattgataa tgaaagtaca agacatggat ggccagtttt ttggattgat aggcacatca 1080 acttgtatca taacagtaac agattcaaat gataatgcac ccactttcag acaaaatgct 1140 tatgaagcat ttgtagagga aaatgcattc aatgtggaaa tcttacgaat acctatagaa 1200 gataaggatt taattaacac tgccaattgg agagtcaatt ttaccatttt aaagggaaat 1260 gaaaatggac atttcaaaat cagcacagac aaagaaacta atgaaggtgt tctttctgtt 1320 gtaaagccac tgaattatga agaaaaccgt caagtgaacc tggaaattgg agtaaacaat 1380 gaagcgccat ttgctagaga tattcccaga gtgacagcct tgaacagagc cttggttaca 1440 gttcatgtga gggatctgga tgaggggcct gaatgcactc ctgcagccca atatgtgcgg 1500 attaaagaaa acttagcagt ggggtcaaag atcaacggct ataaggcata tgaccccgaa 1560 aatagaaatg gcaatggttt aaggtacaaa aaattgcatg atcctaaagg ttggatcacc 1620 attgatgaaa tttcagggtc aatcataact tccaaaatcc tggataggga ggttgaaact 1680 cccaaaaatg agttgtataa tattacagtc ctggcaatag acaaagatga tagatcatgt 1740 actggaacac ttgctgtgaa cattgaagat gtaaatgata atccaccaga aatacttcaa 1800 gaatatgtag tcatttgcaa accaaaaatg gggtataccg acattttagc tgttgatcct 1860 gatgaacctg tccatggagc tccattttat ttcagtttgc ccaatacttc tccagaaatc 1920 agtagactgt ggagcctcac caaagttaat gatacagctg cccgtctttc atatcagaaa 1980 aatgctggat ttcaagaata taccattcct attactgtaa aagacagggc cggccaagct 2040 gcaacaaaat tattgagagt taatctgtgt gaatgtactc atccaactca gtgtcgtgcg 2100 acttcaagga gtacaggagt aatacttgga aaatgggcaa tccttgcaat attactgggt 2160 atagcactgc tcttttctgt attgctaact ttagtatgtg gagtttttgg tgcaactaaa 2220 gggaaacgtt ttcctgaaga tttagcacag caaaacttaa ttatatcaaa cacagaagca 2280 cctggagacg atagagtgtg ctctgccaat ggatttatga cccaaactac caacaactct 2340 agccaaggtt tttgtggtac tatgggatca ggaatgaaaa atggagggca ggaaaccatt 2400 gaaatgatga aaggaggaaa ccagaccttg gaatcctgcc ggggggctgg gcatcatcat 2460 accctggact cctgcagggg aggacacacg gaggtggaca actgcagata cacttactcg 2520 gagtggcaea gttttactca accccgtctc ggtgaagaat ccattagagg acacactggt 2580 taaaaattaa acataaaaga aattgcatcg atgtaatcag aatgaagacc gcatgccatc 2640 ccaagattat gtcctcactt ataactatga gggaagagga tctccagctg gttctgtggg 2700 ctgctgcagt gaaaagcagg aagaagatgg ccttgacttt ttaaataatt tggaacccaa 2760 atitattaca ttagcagaag catgcacaaa gagataatgt cacagtgcta caattaggtc 2S20 tttgtcagac attctggagg tttccaaaaa taatattgta aagttcaatt tcaacatgta 2880 tgtatatgat gatttttttc tcaattttga attatgctac tcaccaattt atatttttaa 2940 agccagttgt tgcttatctt ttccaaaaag tgaaaaatgt taaaacagac aactggtaaa 3000 tctcaaactc cagcactgga attaaggtct ctaaagcatc tgctcttttt tttttttacg 3060 gatattttag taataaatat gctggataaa tattagtcca acaatagcta agttatgcta 3120 atatcacatt attatgtatt cactttaagt gatagtttaa aaaaraaaca agaaatattg 3180 agtatcacta tgtgaagaaa gttttggaaa agaaacaatg aagactgaat taaattaaaa 3240 atgttgcagc tcataaagaa ttgggactca cccctactgc actaccaaat tcatttgact 3300 ttggaggcaa aatgtgttga agtgccctat gaagtagcaa ttttctatag gaatatagtt 3360 ggaaataaat gtgtgtgtgt atattattat taatcaatgc aatatttaaa atgaaatgag 3420 aacaaagagg aaaatggtaa aaacttgaaa tgaggctggg gtatagtttg tcctacaata 3480 gaaaaaagag agagcttcct aggcctgggc tcttaaatgc tgcattataa ctgagtctat 3540 gaggaaatag ttcctgtcca atttgtgtaa tttgtttaaa attgtaaata aattaaactt 3600 ttctggtttc tgtgggaagg aaatagggaa tccaatggaa cagtagcttt gctttgcagt 3660 ctgtttcaag atttctgcat ccacaagtta gtagcaaact ggggaatact cgctgcagct 3720 ggggttccct gctttttggt agcaagggtc cagagatgag gtgttttttt cggggagcta 3780 ataacaaaaa cattttaaaa cttaccttta ctgaagttaa atcctctatt gctgtttcta 3840 ttctctctta tagtgaccaa catcttttta atttagatcc aaataaccat gtcctcctag 3900 agtttagagg ctagagggag ctgaggggag gatcttactg aaagcaccct ggggagattg 3960 attgtcctta aacctaagcc ccacaaactt gacacctgat caggtctggg agctacaaaa 4020 tttcattttt ctcctcactg cccttcttct gagtggcatt ggcctgaatc aaggaaagcc 4080 aggccttpg^ccc^citc'ttt'c^gcttt^t^taaagc aacåcÆt'ciF^Cagagatirc 4140 “ ccttaagtga ctccaggttt tccaccatcc ttcagcgtga attaattttt aatcagtttg 4200 ctttctccag agaaatttta aaataataga agaaatagaa attttgaatg tataaaagaa 4260 aaagatcaag ttgtcatttt agaacagagg gaactttggg agaaagcagc ccaagtaggt 4320 tatttgtaca gtcagagggc aacaggaaga tgcaggcctt caagggcaag gagaggccac 4380 aaggaatatg ggtgggagta aaagcaacat cgtctgcttc atactttttc ctaggcttgg 4440 cactgccttt tcctttctca ggccaatggc aactgccatt tgagtccggt gagggatcag 4500 ccaacctctt ctctatggct caccttattt ggagtgagaa atcaaggaga cagagctgac 4560 tgcatgatga gtctgaaggc atttgcagga tgagcctgaa ctggttgtgc agaacaaaca 4620 aggcattcat gggaattgtt gtattccttc tgcagccctc cttctgggca ctaagaaggt 4680 ctatgaatta aatgcctatc taaaattctg atttattcct acattttctg ttttctaatt 4740 tgaccctaaa atctatgtgt tttagactta gactttttat tgcccccccc cccttttttt 4800 ttgagacgga gtctcgctct gacgcacagg ctggagtgca gtggctccga tctctgctca 4860 ctgaaagctc cgcctcccgg gttcatgcca ttctcctgcc tcagcctcct gagtagctgg 4920 gactacaggc gcccaccacc acgcccggct aattttttgt atttttaata gagacggggt 4980 ttcactgtgt tagccaggat ggtctcgatc tcctgacctc gtgatccgcc tgcctcggcc 5040 tcccaaagtg ctgggattac aggcatgacc caccgctccc ggccttgttt tccgtttaaa 5100 gtcgtcttct tctaatgtaa tcattttgaa catgtgtgaa agttgatcat acgaattgga 5160 tcaatcttga aatactcaac caaaagacag tcgagaagcc agggggagaa agaactcagg 5220 gcacaaaata ttggtctgag aatggaattc tctgtaagcc tagttgctga aatttcctgc 5280 tgtaaccaga agccagtttt atctaacggc tactgaaaca cccactgtgt tttgctcact 5340 cccactcacc gatcaaaacc tgctacctcc ccaagacttt actagtgccg ataaactttc 5400 tcaaagagca accagtatca cttccctgtt tataaaacct ctaaccatct ctttgttctt 5460 tgaacatgct gaaaaccacc tggtctgcat gtatgcccga atttgtaatt cttttctctc 5520 aaatgaaaat ttaattttag ggattcattt ctatattttc acatatgtag tattattatt 5580 tccttatatg tgtaaggtga aatttatggt atttgagtgt gcaagaaaat atatttttaa 5640 agctttcatt tttcccccag tgaatgattt agaatttttt atgtaaatat acagaatgtt 5700 ttttcttact tttataagga agcagctgtc taaaatgcag tggggtttgt tttgcaatgt 5760 tttaaacaga gttttagtat tgctattaaa agaagttact ttgcttttaa agaaacttgg 5 820 ctgcttaaaa taagcaaaaa ttggatgcat aaagtaatat ttacagatgt ggggagatgt 5880 aataaaacaa tattaacttg gaaaaaaaaa aaaaaaaaaa 5920 <210> 186 <211 > 696

<212> DNA <213> Homo sapiens <220> <221 > misc_feature <222> (8)..(8) <223> a or g or c or t/u <400> 186 gactcagnct tcagocgctc tcctccccct gggcaaacag gactcatctg atgatgtgag 60 aagagttcag aggagggaga aaaatcgtat tgccgcccag aagagccgac agaggcagao 120 acagaaggcc gacaccctgc acctggagag cgaagacotg gagaaacaga acgcggctct 180 acgcaaggag atcaagcagc tcacagagga actgaagtac ttcacgtcgg tgctgaacag 240 ccacgagccc ctgtgctcgg tgctggccgc cagcacgccc tcgccccccg aggtggtgta 300 cagogcccac gcattocacc aacctcatgt cagctccccg cgcttccagc cctgagcttc 360 cgatgogggg agagcagagc ctcgggaggg gcacacagac tgtggcagag ctgcgcccat 420 cccgcagagg cccctgtcca cctggagacc cggagacaga ggcctggaca aggagtgaac 480 acgggaactg tcacgactgg aagggcgtga ggcctcccag cagtgccgca gcgtttcgag 540 gggcgtgtgc tggacoccao cactgtgggt tgcaggccca atgcagaaga gtattaagaa 600 agatgctcaa gtcccatggc acagagcaag gcgggcaggg aacggttatt tttctaaata 660 ' aatgctttaa aagaaaaaaa~aaaaamaaa~aaaaaa ---------696— <210> 187 <211 > 586

<212> DNA <213> Homo sapiens <220> <221 > misc_feature <222> (9)..(10) <223> a or g or c or t/u <220> <221 > misc_feature <222> (31)..(31) <223> a or g or c or t/u <220> <221 > misc_feature <222> (44)..(45) <223> a or g or c or t/u <220> <221 > misc_feature <222> (116)..(116) <223> a or g or c or t/u <220> <221 > misc_feature <222> (130)..(130) <223> a or g or c or t/u <400> 187 atgcaaggnn taggcaaaga ttgttgaccc nggagataga ggtnncaatg agccagatca 60 ttccattgca ttccagcttg ggcgacagaa tgagactctg tctcaaaatt aaaaancaaa 120 aaaccaaaan caaatagatg aaaaagtaga ctggagacaa ataaaagtga gtttctaaag 180 gaaattcaca gtaatgctgc attaaacact aagctcactt aggtcacttt ctagtgagct 240 aaccgtaaca gagagcctac aggatacacg tgagataatg tcacgtgtag aagatcgttg 300 tgaattaaag ttcaaaatta agacttctta gattatgatg tagattttag agctccttaa 360 aacataaagc gaatcttata aatgttcaat tctaaagtta ttccacttgg aaaaattagc 420 ttttgggaca atttttaaga acttttgtgt aaaatgcagc tccatgttta gcataatcta 480 aaaataattt caagcaatcc agaatcttcc aagaatgtta ttaaagcttt aaaacaaagc 540 aaaacaaaaa gacccttttg tgccttatat gggaagacta aaaaaa 586 <210> 188 <211 > 1359

<212> DNA <213> Homo sapiens <400> 188 accgggcacc ggacggctcg ggtactttcg ttcttaatta ggtcatgccc gtgtgagcca 60 ggaaagggct gtgtttatgg gaagccagta acactgtggc ctactatctc ttccgtggtg 120 ccatctacat ttttgggact cgggaattat gaggtagagg tggaggcgga gccggatgtc 180 agaggtcctg aaatagtcac catgggggaa aatgatccgc ctgctgttga agcccccttc 240 tcattccgat cgctttttgg ccttgatgat ttgaaaataa gtcctgttgc acoagatgca 300 gatgctgftg'ctgcacagat ccfgtcactg otgccaftga agfttCHoo aalcatcgtc 360' attgggatca ttgcattgat attagcactg gccattggtc tgggcatcca cttcgactgc 420 tcagggaagt acagatgtcg ctcatoottt aagtgtatcg agctgatago tcgatgtgac 480 ggagtctcgg attgcaaaga cggggaggac gagtaccgct gtgtccgggt gggtggtcag 540 aatgccgtgc tcoaggtgtt cacagctgct tcgtggaaga ccatgtgctc cgatgactgg 600 aagggtcact acgcaaatgt tgcctgtgcc caactgggtt tcccaagcta tgtgagttca 660 gataacctca gagtgagctc gctggagggg cagttccggg aggagtttgt gtccatcgat 720 cacctcttgc cagatgacaa ggtgactgca ttacaccact cagtatatgt gagggaggga 780 tgtgcctctg gccacgtggt taccttgcag tgcacagcct gtggtcatag aaggggctac 840 agctcacgca tcgtgggtgg aaacatgtcc ttgctotcgc agtggccctg gcaggccagc 900 cttcagttcc agggctacca cctgtgcggg ggctotgtca tcacgcccct gtggatcatc 960 actgctgcac actgtgttta tgacttgtac ctccccaagt catggaccat ccaggtgggt 1020 ctagtttccc tgttggacaa tccagcccca tcccacttgg tggagaagat tgtctaccac 1080 agoaagtaca agccaaagag gctgggcaat gacatcgccc ttatgaagct ggccgggcca 1140 ctcacgttca atggtacatc tgggtctcta tgtggttctg cagctcttcc tttgtttcaa 1200 gaggatttgc aattgctcat tgaagcattc ttatgatggc tgctttataa tccttgtcag 1260 atattaataa ttccaactcc tgattcatgt tggtgttggc atcagttgat tatcttttct 1320 cattaaaatt gtgatgctcc taaaaaaaaa aaaaaaaaa 1359 <210> 189 <211> 2711

<212> DNA <213> Homo sapiens <400> 189 ttcagaagga ggagagacac cgggocoagg goaocotcgc gggcgggcgg acccaagcag 60 tgagggcctg cagcoggccg gccagggcag cggcaggcgo ggcccggacc tacgggagga 120 agccccgagc cctcggcggg ctgcgagcga ctccccggcg atgcctoaca actooatcag 180 atctggccat ggagggctga accagctggg aggggccttt gtgaatggca gacctctgcc 240 ggaagtggtc cgccagcgca tcgtagacct ggcccaccag ggtgtaaggc cctgcgacat 300 ctctcgccag ctccgcgtca gccatggctg cgtcagcaag atccttggca ggtactacga 360 gactggcagc atccggcctg gagtgatagg gggctocaag cccaaggtgg ccacccccaa 420 ggtggtggag aagattgggg actacaaacg ccagaaccct accatgtttg cctgggagat 480 ccgagaccgg ctcctggctg agggcgtctg tgacaatgao actgtgccca gtgtcagctc 540 cattaataga atcatccgga ccaaagtgca gcaaccattc aacctcccta tggacagctg 600 cgtggccacc aagtccctga gtcccggaca cacgctgatc cccagctcag ctgtaactcc 660 cccggagtca ccccagtcgg attccctggg ctccacctac tccatcaatg ggctcctggg 720 catcgctcag cctggcagcg acaagaggaa aatggatgac agtgatcagg atagctgccg 780 actaagcatt gactcacaga gcagcagcag cggaccccga aagcaccttc gcacggatgc 840 cttcagccag caccacctcg agccgctoga gtgcccattt gagcggcagc actacccaga 900 ggcctatgcc tcccccagcc acaccaaagg cgagcagggc ctctacccgc tgcccttgct 960 caacagcacc ctggacgacg ggaaggccac cctgacccct tccaacacgc cactggggcg 1020 caacctctcg actcaccaga cctaccccgt ggtggcagat cctcactcac ccttggccat 1080 aaagcaggaa acccccgagg tgtccagttc tagctccacc ccttgctctt tatctagcto 1140 cgcccttttg gatctgcagc aagtcggctc cggggtcccg cccttcaatg cotttcccca 1200 tgctgcctoc gtgtacgggc agttcacggg ccaggccctc ctctcagggc gagagatggt 1260 ggggcccacg otgcccggat acccacccca catccccacc agcggacagg gcagctatgc 1320 ctccfctgcc atcgcaggca tggtggcagg aagtgaatac totggcaatg cctatggcca 1380 caccccctac tcctcctaca gcgaggcctg gggcttcccc aactccagct tgctgagttc 1440 occatattat tacagttcca catcaaggcc gagtgcaccg cccaccactg ccacggcctt 1500 tgaccatctg tagttgccat ggggacagtg ggagcgactg agcaacagga ggactcagcc 1560 tgggacaggc cccagagagt cacacaaagg aatctttatt attacatgaa aaataaccac 1620 aagtccagca ttgcggcaca ctccctgtgt ggttaattta atgaaocatg aaagacagga 1680 tgaccttgga caaggccaaa ctgtcctoca agactcctta atgaggggca ggagtcccag 1740 ggaaagagaa ccatgccatg ctgaaaaaga caaaattgaa gaagaaatgt agcccoagcc 1800 ggtaccctcc aaagga’gagaagaagcaats^cegaggaacrttggggggat'ggcgaatggt—Ί-860-tcctgcccgg gcccaagggt gcacagggca cctccatggc tccattatta acacaactct 1920 agcaattatg gaccataagc acttccctcc agcccacaag tcacagcctg gtgccgaggc 1980 tctgctcacc agccacccag ggagtcacct ccctcagcct cccgcotgcc ccacacggag 2040 gctctggctg tcctctttcc tccactccat ttgcttggct ctttctacac ctccctcttg 2100 gatgggotga gggctggagc gagtccctca gaaattccac caggctgtca gctgacctct 2160 ttttcctgct gotgtgaagg tatagcacca cocaggtcct cctgcagtgo ggcatcccct 2220 tggcagctgc cgtcagccag gccagcccca gggagcttaa aacagacatt ccacagggcc 2280 tgggcccctg ggaggtgagg tgtggtgtgc ggcttcaccc agggcagaac aaggcagaat 2340 cgcaggaaac ccgcttcccc ttcctgacag ctcotgccaa gccaaatgtg cttcctgoag 2400 otcacgccca ccagctactg aagggaccca aggcaccccc tgaagccagc gatagagggt 2460 ccctctctgc tccccagcag ctcctgcccc oaaggcctga ctgtatatac tgtaaatgaa 2520 actttgtttg ggtcaagctt ccttctttot aacccccaga ctttggcctc tgagtgaaat 2580 gtctctcttt gccctgtggg gcttctctcc ttgatgcttc tttctttttt taaagacaac 2640 ctgccattac cacatgactc aataaaccat tgctcttcaa aaaaaaaaaa aaaaaaaaaa 2700 aaaaaaaaaaa 2711 <210> 190 <211 >3323

<212> DNA <213> Homo sapiens <400>190 tgcttcataa aatttaoota agoaagtggt cttgcttgoo tcaaatccaa gcagtcttga 60 acacttggag gcaattaatg agtatatctt agtcaaaaga attgttggag ctttttatta 120 aagctgcagt ttcagttctg cttttgggga attgtgctat gaaagcagct gccaaaataa 180 gctcatttat tttcttoaat cccactcagt gctoagtcac tatattctgt ttcctttttt 240 tttttcaagt tgcatatttg gtttcccctt atgattggga aagatgaatt ttcagcagaa 300 aacagtgttt gttcacttto aaagagtgat agtttctaaa aoatttagag caataaatat 360 tcatoagagg taccaagtaa gccagcagaa gagttaaggg ttagagaaat cccttattto 420 atgtcttgac tctaaaatga tcaaagtact tttccttgta atgtggattt cttcttatgc 480 ggatatgcaa aaacttcagt tatacgtagt aatgctagca ggtaatttta gtggacattt 540 tataacaact gtcactttgt tttgccacat gtagagtttg ttcagctatt ttccagatat 600 ctccecacaa aaggaggcaa agggtaccag cttttcaatg agcattacct attacttggc 660 aaagatgatg aagactctat taatagttca tttgataaat gttgacataa ccaacaatag 720 agattaggaa gttagtttta agaaatcaat agcatataga cattaccctc atggagtttg 780 tattctacta cttgaactga ttgtagctat aaaagcatag ttagatagct gaatagttag 840 atcataagca aagaaggcca gaacacatct cttatcaaga aatcaatgaa tagtttatct 900 catttttaaa gcaactttat ccttctttaa ttccttcctt tcttctagtg caaaactact 960 taataaggtt ggtgtttagg ttagtgttca caccattcct catctggtgt gaattacctt 1020 ctctttcttt actatttact aocaacctag tacatgtgtt gaotgaattc ttttcaaaca 1080 atgttgagtt atcatggtgc acctaataaa ttaacaccac agattacagc atccttgctg 1140 attttctcag caaagccaga ttagatggaa ataaacaaag aaaatgatcc tagagtgaat 1200 ttttctagaa aatatctatt atgaaccatg ctgtttaaag tattagcttg aaggtgatgg 1260 atccagctat tcagaaaata actttcatat aaocatgatt ttgcaoagta tgaggtctta 1320 aatgtgtgga aagagataaa ttttttatca ttacoacaaa ccccttttaa agattcaaag 1380 gtggaagaaa gtgatttatt ttttctcttc agcatacata tataaaagac ttgtcagatg 1440 tttaatttgg ggaggttgat aatgaaaoat atcaacagag tatagtagtt atagtagtgt 1500 ttgtgggtaa ataatttcct ggggtcagac atatataaac atatttgctt caaaatgata 1560 aaggcatgaa atcagtctta aaaattgaaa tgggggtgat gggggagaaa aagaagaaca 1620 aatttgaagt gccctttcaa atctgctgga tacaagtatt gaagttttaa gtcatcttat 1680 tctgtctgaa agtgtatttt tcattctaca atagacccaa tcaacaagac gtataacttg 1740 agttgcatga tgttcagttt atgtaatcta ctgttgggat ggtaagaatt gatgtaggct 1800 gtggtgtaag aatgaattaa aatatagttt cactggcttt tctctacata tccactatca 1860 caatggctag gtttcctgtt gctcactgtt ggattctgga gaaaaattta atgaaagatg 1920 atatcagagg-lagaataagt^pggtagag aagaaaggag‘tptapggagggpaaaaa"_1980_ acaaaacata tttttgtgtt atccaaagga gctttttcct tattctgtca agcattgaga 2040 tcttcttcag ctttcaatgt agttgctaaa tacaaataat gctactaggt agtgactaaa 2100 tatagcaaac acttcatcag atattagaat taggtcacac tattgaggtt ataatctgaa 2160 ggttgtgtta catagaaacc actttagatt attatcaact tgggctaggc tttattttat 2220 aatagcatag taagtaatat ctattgtgtc atttcttcaa ccattttatt ctaagatcca 2280 tgaagcttct tgaggccaaa taaaataata agtttagaca agaagtagat tgtgactttt 2340 tttccottag agatactatt tactatctcc tatcctgata ggtggaaggt ttactgaatt 2400 ggaaattggt tgactattag tttttaaota aaatgtgcaa taacacattg cagtttcctc 2460 aaactagttt cctatgatca ttaaactcat tctcagggtt aagaaaggaa tgtaaatttc 2520 tgcctcaatt tgtacttcat caataagttt ttgaagagtg cagattttta gtcaggtctt 2580 aaaaataaac tcacaaatct ggatgcattt ctaaattctg caaatgtttc ctggggtgac 2640 ttaacaagga ataatcccac aatataccta gctacctaat acatggagct ggggctcaac 2700 ccactgtttt taaggatttg cgcttaottg tggctgagga aaaataagta gttcgaggaa 2760 gtagttttta aatgtgagct tatagataga aacagaatat caacttaatt atgaaattgt 2820 tagaacctgt tctettgtat ctgaatctga ttgcaattac tattgtactg atagactcca 2880 gccattgcaa gtctcagata tcttagctgt gtagtgattc ttgaaattct ttttaagaaa 2940 aattgagtag aaagaaataa accctttgta aatgaggctt ggcttttgtg aaagatcatc 3000 cgcaggctat gttaaaagga ttttagctca ctaaaagtgt aataatggaa atgtggaaaa 3060 tatcgtaggt aaaggaaact acctcatgct ctgaaggttt tgtagaagca caattaaaca 3120 tctaaaatgg ctttgttaoa ccagagocat ctggtgtgaa gaactctata tttgtatgtt 3180 gagagggcat ggaataattg tattttgotg gcaatagaca cattctttat tatttgcaga 3240 ttcctcatca aatctgtaat tatgcacagt ttctgttatc aataaaacaa aagaatcctg 3300 ttaaaaaaaa aaaaaaaaaa aaa 3323 <210> 191 <211> 671

<212> DNA <213> Homo sapiens <220> <221 > misc_feature <222> (21)..(21) <223> a or g or c or t/u <220> <221 > misc_feature <222> (49)..(49) <223> a or g or c or t/u <400> 191 tggctctctc ottcaaaagg nccaggccct gtcccocttt otcccogant ccaaccccag 60 ctcccctgtg aagaaaaaag ttaaaaaatt tgttatttat ttgctttttg cgttgggatg 120 ggttcgtgtc cagtcccggg ggtctgatat ggccatcaca ggctgggtgt tcccagcagc 180 cctggcttgg gggcttgacg cccttcccct tgccccaggc catcatctcc ccacctctcc 240 tcccctctcc tcagttttgc cgactgcttt tcatctgagt caccatttac tccaagcatg 300 tattccagac ttgtcactga ctttccttct ggagcaggtg gctagaaaaa gaggctgtgg 360 gcaggaaaga aaggctcctg tttctcattt gtgaggccag cotctggctt ttctgccgtg 420 gattctcccc ctgtcttctc ccctcagcaa ttcctgcaaa gggttaaaaa tttaactggt 480 ttttactact gatgacttga tttaaaaaaa atacaaagat gctggatgot aacttgatac 540 taaccatcag attgtacagt ttggttgttg ctgtaaatat ggtagcgttt tgttgttgtt 600 gttttttcat gccccatact actgaataaa ctagttctgt gcgggtaaaa aaaaaaaaaa 660 aaaaaaaaaaa 671 <210> 192 <211 >3485 <212> DNA <213> Homo sapiens <400> 192 cacaaagaaa aaagaaatac cjgtagaagc gcatcgaaag ctcctggaac agagttgtgt 60 ctcatatttg caaagatgca gaaaaaataa acccgggaca tccagcttto ttttccttto 120 ttctttgact attctgagaa gctatgcgac taggagcaca ttttaggtaa acacgtggct 180 tgagtagcca taaggccact cttccctgtc gtgtgaccog cgcctgggoc tttaagagat 240 attggtgttt gaaaagggag gaatctgttt gccctcagat atttagttca actgcctgca 300 ttgcttccta ttttgttgtc caactctgta gtagttagca ctggccttac caacatgtaa 360 agaaattttc tttactgccc catgagtagt tggaggcaaa gagaaatttt taaagogcag 420 aaaaaggcct gcagggagat ggaatttgtt ctgooagaga aacgagatga tagctgtatt 480 taataaagtt actgacctct tgtcaaaatt taaaacgcaa aagaagatgt ttcaaaatgc 540 agagaatgtc agaaaacaaa aactacaggg accagaccag tataatgttt agttttcatt 600 atactaaott ttgtctagac tggagttgat tcactatttt ttctttaact cctcaggaag 660 caaaccttcc cgatgatgaa gacttcttga aggatttcat gggtgatttg ggatoccagg 720 accatttggc tagtgtgcct aggtgaccao atgattgctg ttttaccagg aatgcagcat 780 cccattgaca aaacaagtgc tctgagaagg tttaaaatac tacagagaat atgggaacac 840 agaccttgaa atttagctga gttgtaacag ctgaaactcc aagaggtgtc ttccttgttt 900 gaggtgaaac tagtgttgct tccagagggc agctggaaac cgtaaagctg tttggaaatc 960 tttttgactg acttgctgac aaagaggtac tgtgatgcat tttaacaata tctaagttga 1020 ttttttttta aatoaaggaa aataaaaacc aagcatgaat gctatggtat gtgccccttt 1080 tgaccatcct gggctgatta acatcattta aatcaaagta atcataaaaa ggcatattct 1140 acttcaatta tgtggtcaaa taagagtaaa oacacacact cacacatgct gaccccaatt 1200 gccagagcat tactgcaota taaattacgg ttaattocoa aattatacta ctgtttatct 1260 tatttaacaa gtcagaaagc acttttaaaa taacttgagg gctacaaggt cattctatta 1320 atgtcattat ccattcgggt tgtaggcatg tggaagtacc cattaaaaga taagttagag 1380 tttaaatact gataaacaaa accttttatt gcaactggac agtttctgga gagttagcgg 1440 aagaatcttg gagtttcctt tggtoagatg aatacaacat ttcacttttg cagcactatt 1500 tagaatgtac tccatggttc tcttgttccc aacttccaaa aagaacagaa aactttggtt 1560 tacacagaao acgggcatct gaggcaggac ctcttccctg ccctttgatc tgactcacac 1620 ctccacatat gacgtaatca acccaaattt gacaccaatt cactcttttc tgcaaagggc 1680 atattttgaa acaagggaca gcctgagggc ggctataatg agaatgttca tgggggttac 1740 tgggtcccta attctgaact tgcttatgac acccagagtg aatagattca gattcagaac 1800 cttctgagaa ataacccaaa gaaaatttgt tacccagcca attcttcgaa agcttaatat 1860 caaaatatat cttttcaaga agaaaatcgt tagagagaag aatgtggagg ggagagaaat 1920 gggtttctca ttgatatgat attttgttaa ccatttcatt ttgaattatt caagttttgg 1980 ttaatattgt attctttttt cgtaactatt ttaccgtgag agtaggtcat tgggttactt 2040 agatatttat ttttacacag ttattagtct tcagatagtt ttattttact tcatatgatt 2100 ttagtttttg tcagtataat tttaaatcat gtttttcttg gtcatctctt tgtgtatatt 2160 gtgtaattgg attttcattg actgcaagtg gagtgtttgc cacteaattc agtactcagt 2220 actatggtga cttgttttca aataagtctc agatacacat ttagggagcc tttgctggcc 2280 gaatatagac tctgtcagga cagcaggtcc cctgatctaa gaattttccc caatggttgc 2340 tctaaaaatg ctgctatttt gctgttcact gtattgcact tagttaaaaa gaagataatg 2400 tgaaagatga gagcagtttt ttaaaggatc ttttcatata ccoaattccc ttattttcag 2460 atgtcccatc aattttagat atgaaagctt taagtaaaag tgtgtatgcc tttctactgt 2520 cagaacagga tggatgoagc ctgggtcaga tttatttaag ataaaaatca tgcagactca 2580 tcattcatat cataggtgaa aaatgtaaaa accaaatggt ttccactaaa gccaccaaga 2640 tcttttagaa atgtttgcac ctttggtggt ggcacaggaa aagagaagaa ttcagctgga 2700 gtgaattcta gaagtagata teagaaacgg ggcatgaaga aoaggggaac tgggtggcat 2760 cagactccta aagaagtgag ttaattttoc ttcccttcca ttcagattca tgccacagct 2820 ccatatcttg agtatgtgta agaggtgagt tccttcttca gccaggggcg gtggctcatg 2880 cctttaatcc caatgctttg ggaggccaag gtgggaggat cacttgtgcc ttggggttca 2940 aggftgcagt gaaccatgartgcaccactg_cactccagcc4gagtgacag agcaagaeGG—3000- tgtctctaaa aatatatata aaaagtaaaa ctaaagaact tcttgcctaa acctgaatta 3060 cogoaatttg ctgagtgact ttgagaaaaa tcagactgtt tagttcagtc gggatgaaaa 3120 gcttgcgatt gcttcccaca agaatgggoa atagtgaogg ctgcaaggta cttttatttg 3180 ttcatgaaag aacgacaatt tttcaaaatg taattaaaca taatagaatg ttttaaacta 3240 ctgggcactg aaaotggaag aaaaaggagg ctttattgaa cattcccctt tttcagttgg 3300 ttcaaagtto agoactgtgg ttatcattgg tgatgccaga aaacattagt agacttagac 3360 aattgctatg gcagtttcta aacagagctt tttotataca ctatttgoaa ctggagtgca 3420 atattgtata ttctgtgtta aagaaataaa gtatttttat catttattaa aaaaaaaaaa 3480 aaaaa 3485 <210> 193 <211 > 1915

<212> DNA <213> Homo sapiens <400> 193 ccatccagaa cgatgaggoc gtggccccgc tcatgaagta cctggatgag aagctggccc 60 tgctgaacgc ctcgctggtg aaggggaacc tgagcagggt gctggaggcc ctgtgggagc 120 tactcctcca ggccattctg caggcgctgg gtgcaaaccg tgacgtctct gctgatttct 180 acagccgctt ccatttcacg ctggaggccc tggtcagttt tttcoacgca gagggtcagg 240 gtttgcccct ggagagcctg agggatggaa gctacaagag gctgaaggag gagctgcggo 300 tgcacaaatg ttccacccgc gagtgcatcg agcagttcta cctggacaag otcaaacaga 360 ggaccctgga gcagaaccgg tttggacgcc tgagcgtccg ttgocattac gaggcggctg 420 agcagcggot ggccgtggag gtgctgcacg ccgcggacct gctccccctg gatgccaacg 480 gcttaagtga ccootttgtg attgtggagc tgggcccacc gcatctcttt ccactggtec 540 gcagccagag gacccaggtg aagacccgga cgctgcaccc tgtatacgac gaactcttct 600 acttttccgt gcctgccgag gcgtgccgcc gccgcgcggc ctgtgtgttg ttcaccgtca 660 tggaccaoga otggctgtcc accaacgact tcgctgggga ggcggccctc ggcctaggtg 720 gcgtcactgg tgtcgcocgg ccccaggtgg gcgggggtgc aagggctggg oagcctgtoa 780 ccctgcacct gtgccggcco agagcccagg tgagatctgc gctgaggagg ctggaaggcc 840 gcaccagcaa ggaggcgcag gagttcgtga agaaactcaa ggagctggag aagtgcatgg 900 aggcggaccc ctgagtccat cagctgccag ccccggccct ggcccccacc ccaagttccc 960 tgaagcatcc tccagctcac tgtggocagc tttgtgcaac cagggcccac ggcgcccctc 1020 ctgtgctgtg acgtgtgtgt cgtggctggc cccgcggcgc ctaccgccct ggccgtgtct 1080 gtctggtgtg tgctgtgaac ccctgcaccc aaccocacat ctgggtggcc aacttggcag 1140 gacttggcca gcagctgccc aggacacagt gcaggccaga gcgggcttga ccacctggtg 1200 ggcctccctg cccgcttcct tgggctcccc ggccctgggt gggcggtgcg cagctggtct 1260 ccagggactc agtgagtggc tgtgctctct gcacaacggg caatgtgcag acgcattttt 1320 ggtaatcaca gctggggagt gaaaagggtg coactggcac cactgggtgg atggtccaga 13 80 gcctccaccc acagagggga tgcaaagggc aggtgagtca agaaccgcat aggtctccag 1440 tccccacggg gctcccaggc cggggaaagg ttcccctgag gtcaotctga ggccagggac 1500 gtcacccaag gctggtggtc agtgtgaagg gctcogtgcc aactggtcag otgtccttca 1560 cgcacatatc cgtggccacc tgagacctgc tccacgaccc ttccaggcag agccgagagt 1620 tcgccccaac ccttccocag gcccagtgtg aaaaacagac tcacaagggg cttottggcc 1680 tgcagcttca tttgcgagag cgccgaggca ggacaoagag cacagctgtg ctggaagtgt 1740 ggggagaacc cggacagctc agtcctgcca gcagccgcaa agagccgagg ctgccaggcc 1800 catttatgtc cctcatgtct ctagattttc tcgtcaccca gcctcaaaaa tatatgtgtc 1860 tgcaaccctc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 1915 <210> 194 <211 >2681

<212> DNA <213> Homo sapiens <400> 194 gggggggctc cgtgacagcc aacgcagtga ccctcgcccc ttccttggca gcacatcatg 60 cttgtgcagc ggcagatgtc tgtgatggaa gaggacctgg aagaattcca gctcgctctg 120 aaacactacg tggagagtgc ttoctcccaa agtggatgct tgcgtatttc tatacagaag 180 ctttcaaatg aatctcgcta catgatctat gagttctggg agaatagtag tgtatggaat 240 agccaccttc agacaaatta tagcaagaca ttccaaagaa gtaatgtgga tttcttggaa 300 actccagaac tcacatctac aatgctagtt cctgcttcgt ggtggatcct gaacaactag 360 atgttcctag acattttctt tatggttcca agtgcaaaao aggtgttctt atctaaaacg 420 tcaattagaa aattatctgc ggttgttaat ctactgtata tttttgtttg gtatatttac 480 taagtgcact ctttcaaaac ttattctata actttatcaa ttcatgtgaa ttttagctca 540 atttteaaag ttcactaata ttctcaatat ttaatgctaa atgctttgct acattgtaac 600 tcacctaaaa ccttttagtg acaaaatcct aatatgtgga aaaaagcata tgcataaagg 660 aataatattg tgaaaatgaa tctgttatga taaagaaaaa ataaagtgga aacttttaga 720 gtattacttc atagggcaga ttttgtaaac tgtcgtatac tgtaaagggt taaatcagcg 780 ttttgtgatt tttaagtaac tgtgagtgaa gtttattctt caacaatgtc tactcoatco 840 ccaacccaac tcacagccct atgactacta tctttgcatt agttaaaaag ttagtatata 900 ggcatcaaac aaccttggct gtaacotata gaatctctat ccatgtatca ggttatagac 960 tggtttttca aaagtgaaca atcctgtgat aagttggagt accatttagt aatacagcaa 1020 cattgtgtca tttattagca tcataattct ttgttatgta agttaaatat atcaagaaag 1080 aagagactgt ttggaaaaat gtggttcaag ttttatgcta tatagttttg gtatgcgata 1140 cagacagcta acttttctta tgaaaaatao atatttgcat gtaaacaatg atttcaaaat 1200 acttgaaaaa taaaatttta acccaaatga ataactaaga aatataaaac aagcacaaaa 1260 tcttagggaa gtcataaaat agtagtgaaa gtattagaca gaagacatct gttttcgaat 1320 ttcaacacta gaatgactaa aactatctac ctatagaact atctgtagat agtatactat 1380 ctacactctg ctcaacaagc tcagaaatta aatattttta gtaataaaaa totgttctgg 1440 ttataaacct tgctaatgaa aatacaatac atataaaaat gtatagccat gttattttct 1500 agtataaatt cctttgaaac tataagtctt tgaggaaaat tataaggtaa aattttcotg 1560 tttttccccc tttgaaaaac tcaggaaaaa aggaagattg aaotaataaa attttatttc 1620 ttaaatataa atttgaccta aaatatttto toaaactaat tcatgaaaca gcaactttta 1680 ccaatacctt tgtatactct cagttctcat tcagtataaa taaaatttta aaatcctttc 1740 atagttctat tagaaataag tagtaaattt tgatatattg tacatacaca cgtgtgtgtg 1800 tgtgtgtgtg tgtgtgtgta tttgtgtgcc tctggtcaao totaaggatg acagacactg 1860 tgtaacaaca cctgggtcaa ctcttttaat ttatatacaa agoaaagaac aacattaatg 1920 gagatgcaca atgattattc aaacaagcta tatatatgta caaaggcaaa cagacacata 1980 acagtctctg cagactgatt gtatatagta agaaaagatc aaaagacttt aaaacctaaa 2040 tgacttttga catacaaact cttcttgaga atgtttgttg taaatggttt caaaaataca 2100 aattatagcc aatcaaaaca ttgctttggt tggtgcattt aagtatccaa ctcaaaaagc 2160 atatcaaata ttttgggtac taggcagttt ccaaagtagc atggtagtat tacttgttaa 2220 aagggttctg ttttcattaa cagtaotaag tggaagggat ctgcagattc caaattggaa 2280 taagctctat catattctga aacaagaatt agaatgactt gagaacgggc aaataacaaa 2340 gcaaaocaat ataattatat ggtcattctg accocagctc ttatacaaat tatacatgta 2400 tttttgtgta tgtttgtgag agttgtatgt atgtgaatgt gtgtgagtgt gtattcacat 2460 acacatatat actggaacot atagtagaaa aggaaaotag tagggcoaaa aaaaaaaaga 2520 aaaagaaaaa gaaaaaagaa aaaaaaagaa aaaactggga cctaagtata aatatctcat 2580 cctaaagtaa acaataagtt tatagttaac gaagattttt ttctatttaa aaccccattt 2640 tcctaaagaa caaaaaaaaa aaaaaaaaaa aaaaaaaaaa a 2681 <210> 195 <211 >2805

<212> DNA <213> Homo sapiens <400> 195 ggcacgaggg cagggggaag ggaagtgogg ctoggtcggc gogggtggag ggggcgtgag 60 gccgccctac ggtggccgtc gagggacggo getacggctc ccacgctagg ccaaacgcct 120 ccggcggccg cgcccgagag ccccttcacc tgcagggcga ccccagccgg cgacgcgtga 180 accacgccct cagccgcctt gcoagcgcoc ccagccgcgc gccocagcac catgcggcog 240 ccctgcgcac ggagcccoga gggacagggg cacccgcagg cccggcccct agcaccgccg 300 gccggccccg aggtccggga cgocggcgcc gocgcggaga gggcaccggg ccgacgcctc 360 cccccagggt cagctgcggg ctcccaggcc taggcgccca tgacccctac gccaaccgcc 420 gcctggacac cgccgccgcc aotgcgacct agcgccgccg ccgccggggo ccaatgcogg 480 tcatgcccat tccgcggcgg gtgcgctcct tccacggccc gcacaccacc tgcctgcatg 540 cggcctgcgg gcccgtgcgc gcctcccacc tggcccgcac caagtacaac aacttcgacg 600 tgtacatcaa gacgcgctgg ctgtacggct tcatccgctt cctactctac tttagctgca 660 gcctgttcac tgcggcgctc tggggtgcgc tggccgccct cttctgccta cagtacctgg 720 gcgttcgcgt cctgctgcgc ttecagcgca agctgtcggt gctgctgctg ctgctgggcc 780 gccggcgcgt ggacttccgc ctggtgaacg agctgctcgt ctatggcatc cacgtcacca 840 tgctgctggt cgggggcctg ggctggtgot tcatggtctt cgtggacatg tgagggccgt 900 gggtgcgagc ttgatgtatc gtcccggcct gtggctgtgt tctctccatg ggtggggtcg 960 gccagcgcct tcccttcgcc catcccccag gcagtcgctg ctgcocggcg cccacggaga 1020 gaaaagaaag ggctgagact tctgtgatgg gggcgcggac accaccccta ggctggcttc 1080 ctggacccac cctccccgta tgcactctca ggggcagcgc ccacctgccg gtggctcctg 1140 ctcacatgtc ttcgggtcgt actgcggggt gggccctccg ttccgcctct ctgtgggcct 1200 ctotccagga ccacagctgc cagggacttt agacatcacc ctgggaggcc cctggacaca 1260 gagggctgtg tgcccaggag caattccgga ggggggccct cctggctgca cagccccttc 1320 tgcgtgccct ggccccagcc ccagccaacg ggacacggaa ggctcccctc gctgacacac 1380 cacactgcca caaagctgct tactctgccc tgggccgcct gaggcctggc actgcccgcg 1440 gaccaccctg tgtgtgtcat cctgaggggc tgtgtgggtc ctgagtcccc agccagcctt 1500 cagggtcccc ttggattgtg tagatgcagt ctagcggggg gccggagaag ggotcaggtg 1560 ggaggggcct cagcaggctc ccagctcagg ggctggcctg gggggaaccc tgggagccag 1620 gggctgactc cagcaacaot ggcctgtctg cctgttctgg gagggctgtg aggatgtctt 1680 gcagatgctc tggatttctg cggaggcacc tccattcctt tctggctttt tttgcggggg 1740 agggctttgg gcctctttct ttgagggaac accgtcaaag aaagcctggg agatcgaggc 1800 ttcagtgagc caggatggaa acgcgtgtcc caagtgtccg gagcaggcgg cagaggcctc 1860 agtgcggcaa acacagcccc agagcctgtg tggcaccagc agcatcttag agccccaggt 1920 atatgctgag atcttatctc acgctgtcct ccagtgtctg gggggcccaa atgatggcac 1980 agggtcaggt gggctggagg ggcgcagatg cctgtgttca gggagggtgg ccaccatggg 2040 ccgaggtctc acccaggacc ccttgctetg ctcctcagcc ttgcagtcac ggcagcacta 2100 tggtggactg cccatggceg tgtgactttg ggggcaagtg ggagggcgcc ctgaataatg 2160 attgcaagga caacaggcag aggctaccct agagcaggac acagggtgtg gtactgacaa 2220 ccctagtgtc acctcaaatc catgtcccca cactctgggc atgggtggga cttgtgaccc 2280 taccctgtca ggcggaccag tggcccagga gccatgagga cagttgtgtg ccactggaag 2340 agaaactttt tgaaaaaccc taaatcaggt agagaaagca aaaaatctct ggccgtaaac 2400 cgtgctctct aatttatcgg cagcttctgt ggatgacctc tgatgagccc gggctgcgtc 2460 cacgccctgg gcaggtaggc gggagcttcc ctgcgtgggc ctcatttctt gctgcagaga 2520 atcttttgca ctaagtcatg ctgtttcctc aaagaagctt tgttttttgt taacgtatta 2580 ctcagagtca cccaagcctc ttggctgagg gtgaaggtgg gacgggaggc gggagggggc 2640 tggtggtgcc gctcgtgcgg tgtcaacgct gcagggagtt gtggcacctt ggtgccctct 2700 gagcacctgg ccgcctgctg tccccggtgc ctgtgaaatt cgtcatgcca tgacccacct 2760 gcattaaacc tattttttta atgtgttaaa aaaaaaaaaa aaaaa 2805 <210> 196 <211 >496

<212> DNA <213> Homo sapiens <220> <221 > misc_feature <222> (2)..(2) <223> a or g or c or t/u <220> <221 > misc_feature <222> (26)..(26) <223> a or g or c or t/u <220> <221 > misc_feature <222> (49)..(49) <223> a or g or c or t/u <220> <221 > misc_feature <222> (60)..(60) <223> a or g or c or t/u <220> <221 > misc_feature <222> (88)..(88) <223> a or g or c or t/u <220> <221 > misc_feature <222> (115)..(115) <223> a or g or c or t/u <220> <221 > misc_feature <222> (124)..(124) <223> a or g or c or t/u <220> <221 > misc_feature <222> (159)..(159) <223> a or g or c or t/u <220> <221 > misc_feature <222> (207)..(207) <223> a or g or c or t/u <400>196 gnggaaacac gggccaaacc cgtgantttg gtgccccttg taaactcanc ccotgcaaan 60 ccaaagaccc caatggattt aaagttgntt ggcatttgta ctggcaaggc aaaanatttt 120 taantacctt ttcctaatac ttattgtatg agcttttgnt gtttacttgg aggttttgtc 180 ttttactaca agtttggaao tatttantat tgccttggta tttgtgctct gtttaagaaa 240 caggcacttt tttttattat ggataaaatg ttgagatgac aggaggtcat ttcaatatgg 300 cttagtaaaa tatttattgt tcctttattc tctgtacaag attttgggcc tcttttttto 360 cttaatgtca caatgttgag ttcagcatgt gtctgtccat ttcatttgta cgcttgttca 420 aaaccaagtt tgttctggtt tcaagttata aaaataaatt ggacatttaa cttgatctcc 480 aaaaaaaaaa aaaaaa 496 <210> 197 <211 >2802

<212> DNA <213> Homo sapiens <400>197 ggcacgaggc aatotgagga gcaggaggac cggggcgccg gtgtcctgcc gcctocttct 60 ccttgctctc acctgogcct attagtccac gcgccttcaa ggccaggggc tacagcccag 120 acagagaggg gacagcagag ggagagagag cacctgagga tacagagctg gcactggact 180 gccttttaac cccccaggtg atgagtgagg ttogaagaac ggaagattta aaaagcagco 240 ggggcctccg tattgaatga aagacccagt gcaaagacat cacoatgaac actagcattc 300 cttatcagca gaatccttac aatccacggg goagctccaa tgtoatccag tgctaccgct 360 gtggagacac ctgcaaaggg gaagtggtcc gcgtgcacaa caaccacttc cacatcagat 420 gcttcacctg tcaagtatgt ggctgtggcc tggcccagtc aggcttcttc ttcaagaacc 480 aggagtaeat ctgcacccag gactaccagc aactctatgg cacccgctgt gacagctgcc 540 gggacttcat cacaggcgaa gtcatctcgg ccctgggccg cacttaccac cccaagtgct 600 tcgtgtgcag cttgtgcagg aagcctttcc ccattggaga caaggtgacc ttcagcggta 660 aagaatgtgt gtgccaaacg tgctoccagt ccatggccag cagtaagccc atcaagattc 720 gtggaccaag ccactgtgcc gggtgcaagg aggagatcaa gcacggccag tcactcctgg 780 ctctggacaa gcagtggcac gtcagctgct tcaagtgcca gacctgcagc gtcatcctca 840 ccggggagta tatcagoaag gatggtgttc catactgtga gtccgactac catgcccagt 900 ttggcattaa atgtgagact tgtgaccgat acatcagtgg cagagtcttg gaggcaggag 960 ggaagcacta ccacccaacc tgtgccaggt gtgtacgctg ccaocagatg ttoaocgaag 1020 gagaggaaat gtacctcaca ggttccgagg tttggoaccc catctgcaaa caggoagcco 1080 gggcagagaa gaagttaaag catagacgga catctgaaac ctccatctca ccccctggat 1140 ccagcattgg gtcacccaao cgagtcatct gcgacatcta cgagaacctg gacctccggc 1200 agagacgggc ctccagcccg gggtacatag actcccccac ctacagccgg cagggcatgt 1260 cccccacctt ctcccgctca cctcaooact actaccgctc tggtgatttg tctacagcaa 1320 ccaagagcaa aacaagtgaa gacatcagcc agacctccaa gtacagtccc atctactcgc 1380 cagaccccta ctatgcttcg gagtctgagt actggaccta ccatgggtcc cccaaagtgc 1440 cccgagccag aaggttctcg tctggaggag aggaggatga ttttgaccgc agcatgcaca 1500 agctccaaag tggaattggc cggctgattc tgaaggaaga aatgaaggcc cggtcgagct 1560 cotatgcaga tccctggacc octocccgga gctcoaccag cagccgggaa gcoctgcaca 1620 cagctggcta tgagatgtcc ctcaatggct cccotoggto gcactacctg gctgacagtg 1680 atcctctcat ctccaaatct gcctccctgc ctgcctaccg aagaaatggg ctgoacagga 1740 caoccagcgc agacctcttc cactacgaca gcatgaacgc agtcaactgg ggcatgcgag 1800 agtacaagat ctacccttat gaactgotgc tggtgactac aagaggaaga aaccgactgc 1860 ccaaggatgt agacaggacc cgtttagagg gaaacttttg gaagagtggc tgcttatgag 1920 attccaaaat gaagtgttgg ccaacaccgc tcatggccat cctggatttt cccagtggct 1980 tcccttcctg ctcgcctccc tgaacagggg agaaagctta acctctctto tcotctccaa 2040 acctttcacc ttgaatgggt aatgtttggt gggggctgtt ccttcttgga gaagccttga 2100 gtcggaccat tttgagatca tggaggaagg atgaagaagt gaaaatgaca ataatgactc 2160 tcaagaggct ggcgatgtga catggcaaat gtagaactga cttaaattga acaaaccctc 2220 actgagcaoc tctgatgttg agcaoctgct gaatactgag cactgaatgg gggaggggga 2280 ggggagcacg gggtgagtca acctgggact cggtctcagg gatatgccta ccaatagcgg 2340 gtatcgtaag gcatgtaccc aaacataacg gatgtaaggc agaaagtgat cggagaagga 2400 atgagaaagt gtgcgtgatg ttaatgaaaa gtcatatgca gctagagcag acccaggaaa 2460 gctttctgga agagattgca tctgaggaaa ttcaggaagg atctttgtag attgggggga 2520 gattctaaat tgaaggggtg atggggtgag gggccagagg gaagtctgct gtgttctaat 2580 gtaggatgtc agccctccct gcaacttctc tttttggcca atgtcttttc actttcctga 2640 occtttagaa tcatccccag ccagacgcaa tcatggaagt tgoottattg toactggtta 2700 agaacttggc gagattgaag ggcttttgtt attgttgttg gatatttttg tttocoataa 2760 aagcacatca tttcaaccct aaaaaaaaaa aaaaaaaaaa aa 2802 <210> 198 <211 >3278

<212> DNA <213> Homo sapiens <400> 198 gaagaattag atacttttga gtgggctttg aagagctggt ctcagtgttc caaaccctgt 60 ggtggaggtt tccagtacac taaatatgga tgccgtagga aaagtgataa taaaatggtc 120 catcgcagct tctgtgaggc caacaaaaag ccgaaaocta ttagacgaat gtgcaatatt 180 caagagtgta cacatccact ctgggtagca gaagaatggg aaoactgcac caaaacctgt 240 ggaagttctg gctatcagct tcgcactgta cgctgocttc agccactcct tgatggcacc 300 aaccgctctg tgoacagcaa atactgcatg ggtgaccgtc ccgagagccg ccggccctgt 360 aacagagtgc cctgocctgo acagtggaaa acaggaccct ggagtgagtg ttcagtgacc 420 tgcggtgaag gaacggaggt gaggcaggto ctctgcaggg ctggggacca ctgtgatggt 480 gaaaagcctg agtcggtcag agoctgtcaa ctgcctcctt gtaatgatga aocatgtttg 540 ggagacaagt ccatattctg tcaaatggaa gtgttggcao gatactgcto catacoaggt 600 tataacaagt tatgttgtga gtcctgcagc aagcgcagta gcaccctgcc aecaccatac 660 cttctagaag ctgctgaaac tcatgatgat gtcatctcta accctagtga cctooctaga 720 tctctagtga tgcctacatc tttggttcct tatcattcag agacccctgc aaagaagatg 780 tctttgagta gcatctcttc agtgggaggt ccaaatgcat atgctgcttt caggccaaac 840 agtaaacctg atggtgctaa tttaogccag aggagtgctc agcaagcagg aagtaagact 900 gtgagactgg tcaccgtaoc atcctcccca cccaccaaga gggtccacct cagttcagot 960 tcacaaatgg ctgctgcttc cttctttgca gccagtgatt caataggtgc ttcttctcag 1020 gcaagaacct caaagaaaga tggaaagatc attgacaaca gacgtccgac aagatcatcc 1080 accttagaaa gatgagaaag tgaaccaaaa aggctagaaa ocagaggaaa acctggaoaa 1140 cctctotott occatggtgc atatgcttgt ttaaagtgga aatctctata gatcgtcagc 1200 tcattttatc tgtaattgga agaacagaaa gtgctggctc actttctagt tgctttcatc 1260 ctccttttgt tctgcattga ctcatttacc agaattcatt ggaagaaato accaaagatt 1320 attacaaaag aaaaatatgt tgctaagatt gtgttggtcg ctctctgaag cagaaaaggg 1380 actggaacca attgtgoata tcagctgact ttttgtttgt tttagaaaag ttacagtaaa 1440 aattaaaaag agataccaat ggtttacact ttaacaagaa attttggata tggaacaaag 1500 aattcttaga ottgtattcc tatttatcta tattagaaat attgtatgag caaatttgca 1560 gctgttgtgt aaatactgta tattgcaaaa atcagtatta ttttaagaga tgtgttctca 1620 aatgattgtt tactatatta catttctgga tgttctaggt gcctgtcgtt gagtattgcc 1680 ttgtttgaca ttctataggt taattttcaa agcagagtat tacaaaagag aagttagaat 1740 tacagotact gacaatataa agggttttgt tgaatcaaca atgtgatacg taaattatag 1800 aaaaagaaaa gaaacacaaa agctatagat atacagatat cagcttacct attgccttct 1860 atacttataa tttaaaggat tggtgtctta gtacacttgt ggtcacaggg atcaacgaat 1920 agtaaataat gaactcgtgc aagacaaaac tgaaaccctc tttccaggac ctcagtaggc 1980 accgttgagg tgtcctttgt ttttgtgtgt gtgtgttctt ttttaatttt cgcattgttg 2040 acagatacaa acagttatac tcaatgtact gtaataatog caaaggaaaa agttttggga 2100 taacttattt gtatgttggt agctgagaaa aatatcatca gtctagaatt gatatttgag 2160 tatagtagag ctttggggct ttgaaggcag gttcaagaaa gcatatgtcg atggttgaga 2220 tatttatttt ccatatggtt catgttcaaa tgttcacaac cacaatgcat ctgactgcaa 2280 taatgtgcta ataatttatg tcagtagtca ccttgctcac agcaaagcca gaaatgctct 2340 ctccagggag tagatgtaaa gtacttgtac atagaattca gaactgaaga tatttattaa 2400 aagttgattt ttttttcttg atagtatttt tatgtactaa atatttacac taatatcaat 2460 tacatatttt ggtaaactag agagacataa ttagagatgc atgctttgtt ctgtgcatag 2520 agacctttaa gcaaactact acagccaact caaaagctaa aactgaacaa atttgatgtt 2580 atgcaaacat cttgcatttt tagtagttga tattaagttg atgacttgtt tcccttcaag 2640 gaaacattaa attgtatgga ctcagctagc tgttcaatga aattgtgaat tagaaacatt 2700 tttaaaagtt tttgaaagag ataagtgcat catgaattac atgtacatga gaggagatag 2760 tgatatcagc ataatgattt tgaggtcagt acctgagctg tctaaaaata tattatacaa 2820 actaaaatgt agatgaatta acctctcaaa gcacagaatg tgcaagaact tttgcatttt 2880 aatcgttgta aactaacago ttaaactatt gactctatac ctctaaagaa ttgctgctac 2940 tttgtgcaag aactttgaag gtcaaattag gcaaaltcca gatagtaaaa caatccctaa 3000 gccttaagtc tttttttttt tcctaaaaat tcccatagaa taaaattctc tctagtttac 3060 ttgtgtgtgc atacatctca tccacagggg aagataaaga tggtcacaca aacagtttcc 3120 ataaagatgt acatattcat tatacttctg acctttgggc tttcttttct actaagctaa 3180 aaattccttt ttatcaaagt gtacactact gatgctgttt gttgtactga gagcacgtac 3240 caataaaaat gttaacaaaa tataaaaaaa aaaaaaaa 3278 <210> 199 <211> 567

<212> DNA <213> Homo sapiens <400> 199 tcctgtgttc tagacctctg gaggctgctg tggggaccac actgatcctg gagaaaaggg 60 atggagctga aaaagatgga atgcttgcag agcatgacct gaggagggag gaacgtggtc 120 aactoacacc tgcctcttcc tgcagcctca cctctacctg cccccatcat aagggcactg 180 agcccttccc aggctggata ctaagcacaa agcccatagc actgggctct gatggctgot 240 ccactgggtt acagaatcac agccctcatg atcattctca gtgagggctc tggattgaga 300 gggaggccct gggaggagag aagggggcag agtcttccct aocaggttto tacacccccg 360 ccaggctgcc catcagggcc cagggagccc ccagaggact ttattcggac caagcagagc 420 tcaoagctgg acaggtgttg tatatagagt ggaatctctt ggatgcagct tcaagaataa 480 atttttcttc tcttttcaaa aatgtataaa aatcattata catagcatta aagaaacatt 540 tttgagaagt acaaaaoaaa aaaaaaa 567 <210> 200 <211 >2907

<212> DNA <213> Homo sapiens <400> 200 cgggogoogc aggagogagt gagotgggag cgaggggcga aggcgcggag aagcccggcc 60 gcccggtggg cggcagaagg ctcagccgag gcggcggcgc cgactccgtt ccactctcgg 120 cccggatcca ggcctccggg ttcccaggcg ctcacotccc tctgacgcac tttaaagagt 180 ctcccccctt ccacctcagg gcgagtaata gcgaccaatc atcaagocat ttaccaggct 240 tcggaggaag ctgtttatgt gatccccgca ctaattaggc tcatgaaota acaaatcgtt 300 tgcacaactt gtgaagaagc gaacaottcc atggattgtc cttggactta gggcgcoctg 360 cccgcctttt gcagaggaga aaaaactttt tttttttttt gcctcccccg agaactttcc 420 ccccttctcc tocctgcctc taactccgat ccccccacgc catctcgcca aaaaaaaaaa 480 aaaaaaaaaa aaagaaaaaa aaagaaaaaa aaagaaaaaa aattacccca atccacgcct 540 gcaaattctt ctggaaggat tttcccccct ctcttcaggt tgggcgcgtt tggtgcaaga 600 ttctegggat cctcggcttt gcctctccct ctccctcccc cctcctttcc tttttccttt 660 cctttccttt ctttcttcct ttccttcccc ccacccccac ccccacccca aacaaacgag 720 tccccaattc tcgtccgtcc tcgccgcggg cagcgggcgg cggaggcagc gtgcggcggt 780 cgccaggagc tgggagccca gggcgcccgc tcctcggcgc agcatgttcc agccggcgcc 840 caagcgctgc ttcaccatcg agtcgctggt ggcoaaggac agtcccctgc ccgcctogcg 900 ctccgaggac cccatccgtc cogcggcact cagctacgct aactccagcc ocataaatoo 960 gttcctcaac ggcttccact cggccgccgc cgcogccgcc ggtaggggcg tctactccaa 1020 cccggacttg gtgttcgocg aggcggtcto gcaeccgccc aaccccgccg tgccagtgca 1080 cccggtgccg ccgccgcacg ccctggccgc ccacccccta ccctcctcgc actcgccaca 1140 occcctattc gcctcgcagc agcgggatcc gtccaccttc tacccctggc tcatccaccg 1200 ctaccgatat ctgggtcatc gcttccaagg gaacgacact agccccgaga gtttcctttt 1260 gcacaacgcg ctggcccgaa agcccaagcg gatccgaacc gccttctccc cgtcccagct 1320 tctaaggctg gaacacgcct ttgagaagaa tcactacgtg gtgggcgccg aaaggaagca 1380 gotggcacac agcctcagcc tcacggaaac tcaggtaaaa gtatggtttc agaacogaag 1440 aacaaagttc aaaaggcaga agctggagga agaaggctca gattcgcaac aaaagaaaaa 1500 agggacgcac catattaaco ggtggagaat cgccaccaag caggcgagtc cggaggaaat 1560 agacgtgacc tcagatgatt aaaaacataa acctaacccc acagaaacgg aoaacatgga 1620 gcaaaagaga cagggagagg tggagaagga aaaaacccta caaaacaaaa acaaaccgca 1680 tacacgttca ccgagaaagg gagagggaat cggagggagc agcggaatgc ggcgaagact 1740 ctggacagcg agggcacagg gtcccaaacc gaggccgcgc caagatggca gaggatggag 1800 gctccttcat caacaagoga ccctcgtcta aagaggcago tgagtgagag aoacagagag 1860 aaggagaaag agggagggag agagagaaag agagagaaag agagagagag agagagagag 1920 agaaagctga acgtgcactc tgacaagggg agctgtcaat caaacaccaa accggggaga 1980 caagatgatt ggcaggtatt ccgtttatca cagtccactt aaaaaatgat gatgatgata 2040 aaaaccacga cccaaccagg cacaggactt ttttgttttt tgcacttcgc tgtgtttccc 2100 ccccatcttt aaaaataatt agtaataaaa aacaaaaatt ccatatctag ccccatccca 2160 cacctgtttc aaatocttga aatgcatgta gcagttgttg ggcgaatggt gtttaaagac 2220 cgaaaatgaa ttgtaatttt cttttccttt taaagacagg ttctgtgtgc tttttatttt 2280 gatttttttt cccaagaaat gtgcagtctg taaacacttt ttgatacctt ctgatgtcaa 2340 agtgattgtg oaagctaaat gaagtaggct cagcgatagt ggtcctctta cagagaaacg 2400 gggagcagga cgacgggggg gctgggggtg gcgggggagg gtgoccacaa aaagaatcag 2460 gacttgtact gggaaaaaaa cccctaaatt aattatattt cttggacatt ccctttccta 2520 acatcctgag gcttaaaacc ctgatgcaaa cttctcottt cagtggttgg agaaattggc 2580 cgagttcaac cattcaotgc aatgcctatt ccaaacttta aatctatcta ttgcaaaacc 2640 tgaaggactg tagttagcgg ggatgatgtt aagtgtggcc aagcgcacgg cggcaagttt 2700 tcaagcactg agtttctatt ccaagatcat agacttacta aagagagtga caaatgcttc 2760 cttaatgtct tctataccag aatgtaaata tttttgtgtt ttgtgttaat ttgttagaat 2820 totaaoaoac tatatacttc caagaagtat gtcaatgtca atattttgtc aataaagatt 2880 tatcaatatg ccaaaaaaaa aaaaaaa 2907

<210> 201 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 201 acttctggtg atgataaaaa tggttttatc acccagatgt gaaagaagct gcctgtttac 60

<210> 202 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 202 gtggttctgt aaaaacgcag aggaaaagag ccagaaggtt tctgtttaat gcatcttgcc 60 <210> 203

<211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 203 tttataagga agcagctgtc taaaatgcag tggggtttgt tttgcaatgt tttaaacaga 60

<210> 204 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 204 cttatgaagc tggccgggcc actcacgttc aatggtacat ctgggtctct atgtggttct 60

<210> 205 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 205 gtgagccagc atttcccata gctaacccta ttctcttagt ctttcaaaat gtagaatggg 60

<210> 206 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 206 ctttacacct gataaaatat tttgcgaaga gaggtgttct ttttccttac tggtgctgaa 60

<210> 207 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 207 gcatacatct catccacagg ggaagataaa gatggtcaca caaacagttt ccataaagat 60

<210> 208 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 208 tgagttcagc atgtgtctgt ccatttcatt tgtacgcttg ttcaaaacca agtttgttct 60

<210> 209 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 209 aagaccgaga ctgagggaaa gcatgtctgc tgggtgtgac catgtttcct ctcaataaag 60

<210> 210 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400>210 ggcatctggc ccctggtagc cagctctcca gaattacttg taggtaattc ctctcttcat 60

<210 211 <211> 60 <212> DNA <213> Artificial Sequence <220 <223> Synthetic construct - oligonucleotide <400 211 tggatgtttg tgcgcgtgtg tggacagtct tatcttccag catgatagga tttgaccatt 60

<210 212 <211> 60 <212> DNA <213> Artificial Sequence <220 <223> Synthetic construct - oligonucleotide <400 212 tcctggcaga gccatggtcc caggcttccc aaaagtgttt gtggcaatta ttcccctagg 60

<210 213 <211> 60 <212> DNA <213> Artificial Sequence <220 <223> Synthetic construct - oligonucleotide <400> 213 tttgatgata gcagacattg ttacaaggac atggtgagtc tatttttaat gcaccaatct 60

<210> 214 <211 > 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400 214 ttcttccagt tgcactattc tgagggaaaa tctgacacct aagaaattta ctgtgaaaaa 60

<210> 215 <211> 60 <212> DNA <213> Artificial Sequence <220 <223> Synthetic construct - oligonucleotide <400> 215 gaacaattgt ggtctctctt aacttgaggt tctcttttga ctaatagagc tccatttccc 60

<210 216 <211> 60 <212> DNA <213> Artificial Sequence <220 <223> Synthetic construct - oligonucleotide <400 216 gttaagtgtg gccaagcgca cggcggcaag ttttcaagca ctgagtttct attccaagat 60

<210> 217 <211> 60 <212> DNA <213> Artificial Sequence <220 <223> Synthetic construct - oligonucleotide <400> 217 cggcctactg agcggacaga atgatgccaa aatattgctt atgtctctac atggtattgt 60

<210 218 <211> 60 <212> DNA <213> Artificial Sequence <220 <223> Synthetic construct - oligonucleotide <400 218 cagggtgttt gcccaataat aaagccccag agaactgggc tgggccctat gggattggta 60

<210> 219 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 219 tgtacagttt ggttgttgct gtaaatatgg tagcgttttg ttgttgttgt tttttcatgc 60

<210 220 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 220 taccaaactg ggactcacag ctttattggg ctttctttgt gtcttgtgtg tttcttttat 60

<210> 221 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 221 cattgaggtt tggatggtgg caggtaaaac agaaaggcaa gatgtcatct gacattaggc 60

<210> 222 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 222 agttcagcac tgtggttatc attggtgatg ccagaaaaca ttagtagact tagacaattg 60

<210> 223 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 223 taaaatttct tgattgtgac tatgtggtca tatgcccgtg tttgtcactt acaaaaatgt 60

<210> 224 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 224 agccatctgg tgtgaagaac tctatatttg tatgttgaga gggcatggaa taattgtatt 60

<210> 225 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 225 cttattgtca ctggttaaga acttggcgag attgaagggc ttttgttatt gttgttggat 60 <210> 226

<211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 226 ctttctagtg agctaaccgt aacagagagc ctacaggata cacgtgagat aatgtcacgt 60

<210> 227 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 227 ttgtcttaaa atttcttgat tgtgatactg tggtcatatg cccgtgtttg tcacttacaa 60

<210> 228 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 228 cctgggggaa aggggcattc atgacctgaa ctttttagca aattattatt ctcagtttcc 60

<210> 229 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 229 ttcattaaca gtactaagtg gaagggatct gcagattcca aattggaata agctctatca 60

<210> 230 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 230 ccaatgcaga agagtattaa gaaagatgct caagtcccat ggcacagagc aaggcgggca 60

<210> 231 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 231 caaggctacg atggctatga tggtcagaat tactaccacc accagtgaag ctccagcctg 60

<210> 232 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 232 agctcacagc tggacaggtg ttgtatatag agtggaatct cttggatgca gcttcaagaa 60

<210> 233 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 233 tccaaagtag aaagggttct tttagaaaac ttgaagaatg tgcctcctct tagcatctgt 60

<210> 234 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 234 gatgcatttt tcagtccctt ttcagagcaa atgcttttgc aatggtagta atgtttagtt 60

<210> 235 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 235 cctgtggggc ttctctcctt gatgcttctt tcttttttta aagacaacct gccattacca 60

<210> 236 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 236 ttgcactaag tcatgctgtt tcctcaaaga agctttgttt tttgttaacg tattactcag 60

<210> 237 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 237 ctggatccca ggccctggca cccctcagga aatacaagaa aaagaatatt cacatctgtt 60

<210> 238 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 238 ttagaggggc cacctatcaa ctcatcagtg ttcaaagaat atgctgggag catgggtgag 60

<210> 239 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 239 ggcccattta tgtccctcat gtctctagat tttctcgtca cccagcctca aaaatatatg 60

<210> 240 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 240 tccccaaaaa cctcacccga ggctgcccac tatggtcatc tttttctcta aaatagttac 60

<210> 241 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 241 gaaattcctc acaccttgca ccttccctac ttttctgaat tgctatgact actccttgtt 60

<210> 242 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 242 tgtctgtcca ccacgagatg ggaggaggag aaaaagcggt acgatgcctt cctgacctca 60

<210> 243 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 243 gtcttatctc tcaggggggg tttaagtgcc gtttgcaata atgtcgtctt atttatttag 60

<210> 244 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 244 ccgagtagta tgggtctctg tgtgagaaac caggagatat tttcatcttg ttcggaaata 60

<210> 245 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 245 ttgtgcaaaa gtcccacaac ctttctggat tgatagtttg tggtgaaata aacaatttta 60

<210> 246 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 246 tccagtattc tgcagggcca gtcagttgta cagaagttgg aatattctgt tccagaatta 60

<210> 247 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 247 gtctcgaaca gcggttgttt ttactttatt tatcttaggc cctcagctcc ctgacgtcct 60

<210> 248 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 248 agtgaatctt ttcctcttgg tagcatcaac actggggata aatcagaacc attctgtgga 60 <210> 249

<211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 249 tgagagccca gaacaagaag gagcagaagg gcactttgac cttcattatt atgaaaatca 60

<210> 250 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 250 ggaagaactg atgcttgctg ctaactaaag ttttggatgt atcgatttag agaaccaatt 60

<210> 251 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 251 gaatgagaga ataagtcatg ttccttcaag atcatgtacc ccaatttact tgccattact 60

<210> 252 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 252 tacggaaagg aaacaggtta tactcttaga tttaaaaagt gaaagaaact gcaggcgcct 60 <210> 253 <211 >2888

<212> DNA <213> Homo sapiens <400> 253 gtggcggcgg aggcggcgga ggccagggag gaagatgtcg taatgagcga tccacagacc 60 agcatggctg ccactgctgc tgtgagtccc agtgactacc tgcagcctgc cgcctccacc 120 acccaggact cccagccatc tcccttagcc ctgcttgctg caacatgtag caaaattggc 180 cctccagcag ttgaagctgc tgtgacacct octgctcccc cacagcccac accgcggaaa 240 cttgtcccta tcaaacctgc occtctccct ctcagccccg gcaagaatag ctttggaatc 300 ttgtcctcca aaggaaatat acttcagatt caggggtcac aactgagcgc ctcctatcct 360 ggagggcagc tggtgttcgc tatccagaat cccaccatga tcaacaaagg gacccgatca 420 aatgccaata tccagtacca ggcggtcoct cagattcagg caagcaattc ccaaaccatc 480 caagtacagc ccaatctcac caaccagatc cagatcatcc ctggoaccaa ccaagccatc 540 ' atcaccccct caccgtecag tcacaagcct gtccccatca agccagcccc catccagaag 600 tcgagtacga ccaccacccc cgtgcagagc ggggccaatg tggtgaagtt gacaggtggg 660 ggoggcaatg tgacgctoac tctgcccgtc aacaacctcg tgaacgccag tgaoaccggg 720 gcccctacto agctcctcac tgaaagcocc ccaaccccgc tgtctaagac taacaagaaa 780 gcaaggaaga agagccttcc tgcctcccag ccccctgtgg ctgtggctga gcaggtggag 840 acggtgctga tcgagaccac cgcggacaac atcatccagg caggaaataa cctgctcatt 900 gttcagagcc ctggtggggg ccagccagct gtggtccagc aggtccaggt ggtgcccccc 960 aaggccgagc agcagcaggt ggtacagatc ccccagcagg ctctgcgggt ggtgcaggcg 1020 gcatctgcca ccctccccac tgtaccccag aagccctccc agaactttca gatccaggca 1080 gctgagccga cacctactca ggtctacatc cgcacgcctt ccggtgaggt gcagacagtc 1140 cttgtccagg acagcccccc agcaacagct gcagccacct ctaacaccac ctgtagcagc 1200 cctgcatccc gtgctcccca tctgagtggg accagcaaaa agcactcagc tgcaattctc 1260 cgaaaagagc gtcccctgcc aaagattgcc ccagccggga gcatcatcag cctgaatgca 1320 gcccagttgg cggcagctgc ccaggcaatg cagacoatca acatcaatgg tgtccaggtc 1380 oagggcgtgc ctgtcaocat caccaacaca ggcgggcagc agcagctgac agtgcagaat 1440 gtttctggga aoaacctgac catcagtggg ctgagcccca cccagatcca gctgcaaatg 1500 gaacaagccc tggccggaga gacccagccc ggggagaagc ggcgccgcat ggcctgcacg 1560 tgtcccaact gcaaggatgg ggagaagagg tctggagago agggcaagaa gaagcacgtg 1620 tgccacatcc ccgactgtgg caagacgttc cgtaagacgt ccttgctgcg tgcccatgtg 1680 cgcctgcaca ctggcgagcg gccctttgtc tgcaactggt tcttctgtgg gaagaggttc 1740 acacggagtg acgagotooa aoggcatgot cgcaoccaca caggggacaa acgcttcgag 1800 tgcgcccagt gtcagaagcg cttcatgagg agtgaccacc tcaccaagca ttaoaagacc 1860 cacctggtca cgaagaactt gtaaggccaa ctgcggcggg aggccctgaa gatgcagtcc 1920 cccaoctgtg tcctocctgg gcccctggtg gaaaggagoc ctgtggctgc ottgggcctg 1980 coctcagccc cactcctgtt ctgcaactgt coooacagga aggggototg ttccctgtat 2040 tgtcctoott ctgaagcccc ttggctotgo cttggccctt cccctcaoca ogagctoccg 2100 gcctgcooag actgtggaca ctggcogtgc ccaatgagac gttctaaacc aggacgcgtg 2160 ggaaccctta tttccaaagg aaaaacatgc atttoactcc gtcgaggagc aaagtgagcc 2220 cctacccccc accccgatcc ccgctcccaa cactgccgga gtcgcgtcat gccatgcccc 2280 ctctcctgca cctccctggc cctgccggcc actgtggacg ccctggggct tggcacccac 2340 ctctggagaa actcggggcc acctccactc catgtgccca gccccgccac aacctctcct 2400 ccagcacatt ccagctctat ttaaaaagta aagacaccca ccgactcctg atccccctct 2460 ttttctatgg agaacgttgc cttatactct ctacttcaga tgatgaacac tgtgtactgt 2520 gtgtgcttta aagaagtttt atttaattgc tcccttcttc ctttccttgt tattcacctc 2580 cctgatgcct gctttcagtt gagggttggg ggcaatgatg agcatatgaa ttttttctca 2640 ctctagcaat tcocttttct aaatgacaca gcatttaaac tcaaatctgg attcagataa 2700 cagcacotgc acatcctgca cctcctccct ctcccttcac ctcacccctg cccggcccaa 2760 gctctacttg tgtacagtgt atattgtata atagacaatt gtgtctacta catgtttaaa 2820 aacacattgc ttgttatttt tgaggctttt aaattaaaca aaaatocaac tttaaaaaaa 2880 aaaaaaaa 2888 <210> 254 <211> 999

<212> DNA <213> Homo sapiens <400> 254 cccgcgtcgg tgcccgcgcc cctccccggg ccccgccatg ggcctcaccg tgtccgcgct 60 cttttcgcgg atcttcggga agaagcagat gcggattctc atggttggct tggatgcggc 120 tggcaagacc acaatcctgt acaaactgaa gttgggggag attgtoacoa ccatcccaac 180 cataggcttc aatgtagaaa cagtggaata taagaacato tgtttcacag tctgggaogt 240 gggaggccag gacaagattc ggcctctgtg gcggcactac ttccagaaca ctcagggcct 300 catctttgtg gtggacagta atgaccggga gcgggtccaa gaatctgctg atgaactcca 360 gaagatgctg caggaggacg agctgcggga tgcagtgctg ctggtatttg ccaaoaagca 420 ggacatgccc aacgccatgc ccgtgagcga gctgactgac aagotggggc tacagcactt 480 acgcagccgc acgtggtatg tccaggccac ctgtgccacc caaggcacag gtctgtacga 540 tggtctggac tggctgtccc acgagctgtc aaagcgctaa ccagocaggg goaggcocct 600 gatgcccgga agctcctgcg tgcatccccg gatgaocata ctcccggact ootoaggcag 660 tgccctttcc tcccactttt octcccocat agcoacaggc ctctgctcct gctcctgcct 720 gcatgttctc tctgttgttg gagcotggag ccttgctctc tgggcaoaga ggggtccact 780 ctoctgcctg ctgggaccta tggaaggggc ttcctggcca aggccccctc ttccagagga 840 ggagcaggga tctgggtttc cttttttttt tctgttttgg gtgtactcta ggggocaggt 900 tgggaggggg aaggtgaggg cttcgggtgg tgctataatg tggcaotgga tcttgagtaa 960 taaatttgct gtggtttgaa aaaaaaaaaa aaaaaaaaa 999

<210> 255 <211 >3487 <212> DNA <213> Homo sapiens <400> 255 gtggcggtgg ctgcggcgac ggcagaggcg aagggagcog gatcgccgac ctgagcggga 60 ggcggcggtg gcggccatgg cggcagatgg agagcgttcc ccgctgctgt ctgagcccat 120 cgacggtggc gcgggcggca acggtttagt ggggcccggc gggagtgggg ctgggcccgg 180 gggaggcctg accccctccg caccaccgta cggagccggt aaacatgccc cgccccaggg 240 taagccgggg ogggtcogag gtgctccccg gggtactctg aaagccgggg agggggcggg 300 accgagggcg gaggcgggtc ccagtcgoca ggtgcgggao tgctgcaoct gtgactgggc 360 gaggcttcct tccctcogfa atcgcgacoa cagcctaggg acggaagggg gttctgagca 420 acctgataga agtgccaatt atgagaagco ctccgagctt ggtcagaggg ttgaagatca 480 gaaggacttc cctaccaccg tggagcatca gtgggggtgt aagtgatccc agcccttota 540 tttgcttcct ctccagcatt tcccccgttt occgaggggc atccagccgt gttgcotggg 600 gaggacccao ccccctattc acccttaact agcccggaca gtgggagtgc ccctatgatc 660 acctgcogag tctgccaatc tctcatcaac gtggaaggca agatgcatca gcatgtagtc 720 aaatgtggtg tctgcaatga agccaccgtg agttacacat atctatgaaa tgggccctgt 780 ttcctggatc ctctttctga tgtcttggtt ctagaccctg accttccggc tattagccaa 840 gtgcttttga tgatacccag gtttcagttc caggtgtctc acacagccat ttccccagaa 900 gccactcacc aaagctaatg ttcactttct ctcactttta cacetagcct agttcctatt 960 tgcaaatctc atgatatagt otttctttta tttctccttc ctggttagca ccttattttt 1020 ctgatctcat aaagtgtttt tggagggaag tggaggggat tgggattaga ggtttgcttg 1080 ctgatgacco tattattctc tagccaatca agaatgcacc ccoagggaaa aaatatgtto 1140 gatgcccctg taactgtctc cttatctgca aagtgacatc ccaacggatt gcatgcccto 1200 gtccotactg gtaagaggca taaggtgggg aagggcctaa gtggggaact ggaaagtcaa 1260 aaaaggatga gcgtatacag agaatgtaaa ggtgagagag cctagtgttt atttaggaga 1320 aaaggctttg aagcatgtgc otcaggaatg ttatagctgt ctttctcgtt tctcaataaa 1380 aatattgaga tgaaatgatg tcgtttcgga gaatagagag ccttggggac tgggtgtgtt 1440 atcotgaggt cggaggggaa ttggggacct gaagtttaaa cagtgctctt tctttctcaa 1500 ggattcttga gggtatacag ttgggggaca gagtatctta agtacagaga agtcgagtga 1560 cttaatagac agggagtggg ggatgtggaa cagggaotgt gaagattttt aggattaaaa 1620 atttttcaaa cacaagtttg aaaatacaag tcttttfctt ttgtatagca aaagaatcat 1680 caacctgggg cctgtgcatc ccggacctct gagtccagaa ccccaaccca tgggtgtcag 1740 ggttatotgt ggacattgca agaatacttt tctggtgagg aaggggtatt gggaagggga 1800 ggggaaagga gactaagagt catttcgagt atatttctta gagtaatggt aatgaoccct 1860 gaaaggtctg tcctatggga acatgttctg catccccacc ccaaggttct cattgaggga 1920 gaccctgctt gtgctattat ttttgttttc tttctccata gtggacagag ttcacagacc 1980 gcactttggc acgttgtcct cactgcagga aagtgtcatc tattgggcgc agatacccac 2040 gtaagagatg tatctgctgc ttcttgcttg gcttgctttt ggcagtcact gccactggcc 2100 ttgccgtgag tacccttgcc ccaacctctt tcattctgca gcctcatctc cataggctaa 2160 gatttgggaa actgctaccc taaaaaaaag tggaagaaac ttaggggact agtttgtttt 2220 gttttaagat atggatgagc taaagtgcaa agtggotgat caaacagact ttattactac 2280 tacaagagtg aaaaaoagcc ttcctttcto tgtaggatga ggataggaca gtgaaattct 2340 taatttaaga gttgctattt ttcaaacctg gctcagttgt cagatattaa gaaaaactga 2400 gatacagtgt gggatgggat gagtatgtta cgcctaaggg aaggaagctg atcagctctg 2460 cctttaagaa ggtccctgag ggtggctaca tgtggataag gaacaaggac tgaagcgtga 2520 gttattactg ttcttagaac taataggagg tagtggagac caacattaac cccatctttc 2580 ttttcttctc octccttatc ttcatoagtt tggcacatgg aagcatgcac ggcgatatgg 2640 aggcatctat gcagootggg catttgtcat cctgttggct gtgctgtgtt tgggccgggc 2700 tctttattgg gcctgtatga aggtcagcca ccctgtccag aacttctcct gagcctgatg 2760 acccacagac tgtgcctggc ccctccctgg tggggacagt gacactacga agggagctgg 2820 ggtagttaaa ggctcccggg gcttctagaa ggaagccaag cagctgcctt cottttccct 2880 ggggagaggt aggaaggaac caggccctca cttaggtttg gaggggcaga taagagcact 2940 gctgaccatc tgctttcctc caagggttgc tgtgtctagg gtgaagtagg caaaacgttg 3000 cccttaaaac tgggccctga agacggttcc agccttgtcc ttcctgtgtg ctccotgaga 3060 gccattcctg tcccttacac attcoagggc agggtggggg tgggtagccc tgggggttcc 3120 cctccctctt gtgcaccatt aggactttgc tgotgctatt gcacttcaco agaggttggo 3180 tctggcctca gtaccctcag tctcctctcc coaoattgtg toctgtgggg gtggggtcag 3240 ccgctgctct gtacagaacc acaggaaotg atgtgtatat aactatttaa tgtgggatat 3300 gttcccctat tcctgtattt cccttaattc ctcctcecga ccttttttac ccccccagtt 3360 gcagtattta aotgggctgg gtagggttgc tcagtctttg ggggaggtta gggacttatc 3420 ctgtgcttgt aaataaataa ggtcatgact ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3480 aaaaaaa 3487 <210> 256 <211 > 1651

<212> DNA <213> Homo sapiens <400> 256 ctgtcagcac ggggcctggc atgtaattgg tctgcaccca ctggtgcact gaactgccat 60 aacctcaggt tttctttctt gctgataccc ctgggtcatg ttctttggca aataacatga 120 ttcattatga agtagagttc agcaaaggac aaggatgaaa gttgtcattt agagaactgc 180 cattcagact ttcttgtcta ggtaaagagc aaggtcttct ctcttttcaa ctcattttct 240 aaatttaaac tgacgatgag aatatggatg atgtgtagct tccttctccc ccactgattt 300 ttggttcagg ctctgggttt ttggcaagaa cttacagato tcacttatta ttggccaccc 360 ttctgcttta agacctgtca gggcttgtct gaaataaaac tggaagcact tctgattcca 420 tcctcactgc tttcctcctt caccgtcaga cagcattact gtatagcact gagtgagggg 480 ccctgaoact ggaaggtggc aggtggggcc tggccgocag tgaggtatca tcatttgtgt 540 gtgctcatgt gtgcgttggg cttgttgtat ctgaggcatg aacattcoat atacacggct 600 taaagagttt tcttcccata ccgaaagcat atattcggag aggacccaac ttattcagca 660 tagccttgtt cccatagtag ocatcctatt cccccacagc ctctacttta ggaaagctcc 720 ccgtccccat atgaaatcca aaccaaaaaa gatatatcac tttcagctca attattccat 780 aattacaaga tattaggcta gtgggctctt tattggttgg gtcttatatt aatgttatat 840 gctagccttg taattttgag ctcctctatg gatgttaatt ttagtgaaac tctatattga 900 agaaaagatg ggactaaggg ggagacagga ggaggaaaga aagcagagac aggcaaagaa 960 tcatagcctg aaattcaaca gcaagcatgg cttatgaaga tcaagttata tttttgcttc 1020 atgaatcatt gtcagacaaa ttaagaacat attgtttctt atttatctat tgtcaaggat 1080 tcactatcag acactaagaa tgaatcttga ttttoataag ctctgttgac accatggagc 1140 cacagagcat aaaacttgca tctaataaag aaagtgcaac atggaacagc agggagtgga 1200 ataccagcac aactcacagc tgcttcctgt tcctcgtccc tgttttcagg aatgtttctt 1260 agcaggaagt tttttaatag accgagaatt tgttatatgt attctaagaa aagttgtagt 1320 tgtagatgca ttactctccc aaatcttaga gatoagggat gattatgttc oatttttgtt 1380 tggtgagttc ccatctttgt atgtacctcc ttgctcccgg ctgtcctcct ctcctcttcc 1440 ctagtgagtg gttaatgagt gttaatgcct aaaccatact tgttttatgg acacttctat 1500 aatggattcg ttgcataatt ttcatgcagt gtatagtgtt actagttgga aattcttgga 1560 ggactcttag ctgtctgatg aaattcctag tagaaatttt tgttttgaat tcctaaagtt 1620 gaaatatgaa aattatattt taatttgatt c 1651 <210> 257 <211 > 2511

<212> DNA <213> Homo sapiens <400> 257 agtttttctg gtagaaggcg gggttctcct cgtacgctgc ggagtctctg cggggtgtag 60 accggaatcc tgctgacggg cagagtggat cagggaggga gggtcgagac acggtggctg 120 caggtctgag acaaggctgc tccgaggtag tagctctctt goctggaggt ggocattcat 180 tcctggagtg ctgctgagga gcgagggccc atctggggtc tctggaagtc ggtgcccagg 240 cctgaaggat agcccccctt gcgcttccct gggctgcggc cggccttctc agaacgaagg 300 gcgtccttcc accccgcggc gcaggtgacc gctgocatgg cttttcccca tcggccggac 360 gcccctgagc tgcctgactt ctccatgctg aagaggctgg ctcgagacca gctcatctat 420 ctgctggagc agcttcctgg aaaaaaggat ttattcattg aggcagatct catgagccct 480 ttggatcgaa ttgccaatgt ctccatcctg aagcaacacg aagtagacaa gctatacaag 540 gtggagaaca agccagccct cagotccaat gaacaattgt gcttcttggt cagaccccgc 600 atcaagaata tgcgataoat tgccagtctt gtcaatgctg acaaattggc tggccgaaot 660 cgcaaataca aagtgatctt cagccctcaa aagttctatg cgtgtgagat ggtgcttgag 720 gaagagggaa tctatggaga tgtgagctgt gatgaatggg ccttctcttt gctgcctctt 780 gatgtggatc tgctgagcat ggaactacca gaatttttoa gggattaott tctggaagga 840 gatcagcgtt ggatcaacac tgtagctcag gccttacacc ttctcagcac tctctatgga 900 ccotttooaa actgctatgg aattggcagg tgcgccaaga tggcatatga attgtggagg 960 aacctggagg aggaggagga tggcgaaacc aagggccgaa ggccagagat tggacatatc 1020 tttctcttgg acagagatgt ggactttgtg acagcacttt gctcccaagt ggtttatgag 1080 ggcctagtag atgaoacctt ccgcatcaag tgtgggagtg tcgactttgg cccagaagtc 1140 aoatcctctg acaagagcct gaaggtgcta ctcaatgccg aggacaaggt gtttaatgag 1200 attoggaacg agcacttctc caatgtcttt ggcttcttga gccagaaggc ccggaacttg 1260 caggcccagt atgatcgccg gagaggoatg gacattaagc agatgaagaa tttcgtgtcc 1320 caggagctca agggcctgaa acaggagcac cgcctgctga gtctccatat tggggcctgt 1380 gaatccatca tgaagaagaa aaccaagcag gatttccagg agctaatcaa gactgagcat 1440 gcactgctag aggggttcaa catccgggag agcaccagct acattgagga acacatagac 1500 cggcaggtgt cgcctataga aagcctgcgc ctoatgtgcc ttttgtocat cactgagaat 1560 ggtttgatcc ccaaggatta ccgatctctg aaaacacagt atctgcagag ctatggccct 1620 gagcacctgc taaccttctc caatctgcga agagctgggc tcctaacgga gcaggccccc 1680 ggggacaccc tcacagccgt ggagagtaaa gtgagcaagc tggtgaccga caaggctgca 1740 ggaaagatta ctgatgcctt cagttctctg gccaagagga gcaattttcg tgccatcagc 1800 aaaaagctga atttgatccc acgtgtggac ggcgagtatg atotgaaagt gccccgagac 1860 atggcttacg tcttoagtgg tgcttatgtg cccctgagct gccgaatcat tgagcaggtg 1920 ctagagcggc gaagctggca gggccttgat gaggtggtac ggctgctcaa ctgcagtgac 1980 tttgcattca cagatatgac taaggaagac aaggcttcca gtgagtccct gcgcotcatc 2040 ttggtggtgt tcttgggtgg ttgtacattc tctgagatct cagccctccg gttcctgggc 2100 agagagaaag gctacaggtt cattttcctg acgacagcag tcacaaacag cgctcgcctt 2160 atggaggcca tgagtgaggt gaaagcctga tgtttttccc ggccagtgtt gacatcttcc 2220 ctgaacacat tcctcagtga gatgcaggca totggcaccc agotgctata accaagtgtc 2280 caccaactac ctgctaagag ccgggagcat ggaacgtgtt gggatttaga gaacattatc 2340 tgagaaaaga gttcacttcc tgctcccagg atatttctct tttotgttta tgaagtacaa 2400 cocatgctgc taagatgcga gcaggaagag gcatcctttg ctaaatcctg tttgaatgte 2460 attgtaaata aagcctctgc tctcagatgt aaaaaaaaaa aaaaaaaaaa a 2511 <210> 258 <211> 2401

<212> DNA <213> Homo sapiens <400> 258 ggcacgaggg gtcgogotgc cgccgtttta tttgaagaca tcgtccagtt otgaccatgg 60 actcgcagcc atcggocctt agtttccatc ccctctagtg ggccttcggg ggctctactg 120 acgtccctcc ttcccttggt accgggccgg ggaagtgttc tcgggcgcgg gaggttccgc 180 atgcccaggc ctggccaggg gagatgaccg atccgtcgct ggggctgaca gtccccatgg 240 cgccgcctct ggccccgctc cctccccggg acccaaacgg ggcgggatcc gagtggagaa 300 agcccggggc cgtgagcttc gccgacgtgg ccgtgtactt otcccgggag gagtggggct 360 gcctgcggcc cgcgcagagg gccctgtacc gggacgtgat gcgggagacc tacggccacc 420 tgggcgcgct cggtgagagc cccacctgct tgcctgggcc ctgcgcctcc acaggccctg 480 ccgcgcctct gggagctgcg tgtggagttg ggggooccgg ggccgggcag gcggcctcct 540 cgcagcgtgg ggtttgcgtt cttctccccc aggagtcgga ggcagcaagc cggcgotcat 600 ctcctgggtg gaggagaagg ccgaactgtg ggatocggct gcccaggatc cggaggtggc 660 gaagtgtccg acagaagcgg acccagcaga ttccagaaac aaggaagagg aaagacaaag 720 ggaagggaog ggagccotgg agaagcccga ccctgtggcc gccgggtctc ctgggctgaa 780 ggotcccoaa gccocctttg ccgggttgga gcagctgtcc aaggcccggo gccggagtcg 840 cccccgcttt tttgcccacc cccctgtccc ccgagotgac cagcgtoacg gctgctacgt 900 gtgcgggaag agcttcgcct ggcgctccac actggtggag cacatttaca gccacagggg 960 cgagaagccc ttccactgcg cagactgcgg caagggcttc ggccacgctt cctocctgag 1020 caaacaccgg gccatccatc gtggggagcg gccccaccgc tgtcccgagt gtggtcgggc 1080 cttcatgcgc cgcacggcgc tgacttctca cctgcgcgtt cacactggcg agaagccota 1140 ccgctgcccg cagtgtggcc gctgottogg cctgaagacc ggoatggcca agcaccaatg 1200 ggtccatcgg ccogggggcg aggggcgtag gggccggcgc cctggggggc tgtotgtgac 1260 cctgactcct gtccgcgggg acctggaccc gcctgtgggc ttccagctgt atccagagat 1320 attccaggaa tgtgggtgac ggcctaaaaa gtgaccatct agacattgtg ggcggcccga 1380 gatgggctca ggggcccgaa cctctgcagc ggcctgcagg gaggtcccag aatccaccgc 1440 aagagctggc ctggggtgcg gacagtctga tcttgggctc tcagcagcct cttctgccag 1500 caccttgcto ccogctgccc tgggctctcc aaggccccct ttgctgaggc agggctgagg 1560 tgagaacccc ccagacctcc atacagggaa gcaaaagctg tttctcotcc cagagatgct 1620 aagaggattg aggtagagaa gaaccttgtt ttctctgttg tctttttctt tttacttttt 1680 taattttttg agacggagtt ttgctcttgt tgcccaggct ggagtgcaat ggtgcgatct 1740 cgactcactg caacttccac ctcctggagt caagcgattc tcctgcctca gccacccaag 1800 tagctggaat taoaggcacc tgccactatg cccggctaac tttttgtatt tttagtagag 1860 atggggtttc accatgttgg ctaggctggt ctcgaactco tgccctcagg tgatccaccc 1920 acctctgcct cccaaagtgc tgggattaca ggcgtgagoo acctoaootg gccttttctt 1980 ttttattctt tgaccttccc acaagacaat acccattgtc tgtttttttt gtttatttat 2040 ttacttatta agacagcatc ttgctcctca cccaggctgg aatgcagtgg tgtgaactgg 2100 gctcactgca gcctagacct gctgggctca aggaatcctc ctgccccago ctctcagatg 2160 gctgtgacta caggtgggca acactatgcc tggttaattt ttaaattttt ttgoagagat 2220 ggggttccca ctatgttgat caggctggtc tcaaactcct cggttcaagc aattcgccca 2280 ccttggcctc ccaaagtgct gggattacag gggagccact gcactggcct tcattgtctt 2340 tttgctgcac aacctaaaaa accagtgacc ctgtattgga aaaaaaaaaa aaaaaaaaaa 2400 a 2401 <210> 259 <211 >2384

<212> DNA <213> Homo sapiens <400> 259 gccatggccg ccggccccgc gccgcccccc ggccgccccc gggcgcagat gccgcatctg 60 aggaaggtgc gaggcggatg gagcgggtgg tcgtgagcat gcaggacocc gaccagggcg 120 tgaagatgcg gagccagcgc ctgctggtca ccgtcattcc ccacgcggtg acaggcagcg 180 acgtcgtgca gtggttggcc cagaagttct gcgtctcgga ggaggaggcc ctgcacctgg 240 gcgccgtoct ggtgoagcat ggctacatct acccgctgcg cgacccocgt agcctcatgc 300 tccggccaga cgagacgccc tacaggttcc agaccccgta cttctggaoa agtaccctga 360 ggccggctgc agagctggac tatgccatct acctggccaa gaagaacatc cgaaaaoggg 420 ggaccctggt ggattatgag aaggactgct atgaccggct acacaagaag atcaaocaog 480 catgggacct ggtgctgatg caggcgaggg agoagctgag ggcagccaag cagcgcagoa 540 agggggacag gctggtcatt gcgtgccagg agcagaccta ctggctggtg aacaggcccc 600 cgcccggggc ccccgatgtg ctggagcagg gtccagggcg gggatcctgc gctgccagcc 660 gtgtgctcat gaccaagagt gcagatttcc ataagcggga gatcgagtac ttoaggaaag 720 cgetgggcag gacccgagtg aagtcctccg tctgccttga ggcgtacctg agtttctgcg 780 gccagcgtgg aocccacgat cccctcgtgt cggggtgcct gcccagcaat ccctggatct 840 oagacaatga cgcctactgg gtcatgaatg cccccacggt ggctgccccc acgaagctcc 900 gtgtggagag atggggcttc agcttccggg agctcotgga ggaccccgtg gggcgggccc 960 acttcatgga ctttctggga aaggagttca gtggagaaaa cctcagcttc tgggaggcat 1020 gtgaggagct tcgatatgga gcgcaggccc aggtccccac cctggtggat gccgtgtacg 1080 agcagttcct ggcccccgga gctgccoact gggtcaacat cgacagccgg accatggago 1140 agaccctgga ggggctgcgc cagccccacc gctatgtcct ggatgacgcc cagctgcaca 1200 tatacatgct catgaagaag gactcctacc caaggttcot gaagtctgac atgtacaagg 1260 ccctcctggc agaggctggg atcccgctgg agatgaagag acgcgtgttc ccgtttacgt 1320 ggaggccacg gcactcgagc cccagccctg cactccttcc cacccotgtg gagccoacag 1380 cggcttgtgg occtgggggt ggagatgggg tggcctagtg gacctggccc atotgccact 1440 ctagtccctg cagctcaacg tcctgcgtga atgcagoagc cacccccgtc ttggcccagg 1500 tcctgggggc tgctgaaccc agcaccagtg tccccttgtg ccoagggggc ccagtcttct 1560 gtggggtgca oagoctcoct ccctccagca agccctccct gcocagaagg aatgggtcca 1620 ggtgtggatt cooagggagg gggttcattg gctcagcttg ggtcagggca gagcctgtta 1680 cotgaagaga ggtgagacca aggccaoagg gagctccacc ttctctggtc ttcagtccag 1740 oactgggtgc ccatccccat ctctaaaacc agtaaatcag ccagcgaata cccggaagca 1800 agatgcacag gcgggcggct tcccacacac ccgtcaoaag acgcggacat gcaggtctcg 1860 gogcgagctc tgccccgtcc aagagcctct ccgctgtcgc coagtgtgag cotggaagag 1920 gacccaagag agtgccgtgc tgaggctgcc togaggtcac tgccttccgg agctgcgcot 1980 attcctccct cgccaaacgc gttccagaat ttgtccacag gtgcgccggc acctgctttc 2040 ccacctcgag gccgcggoct cccccccgat ttatagacaa ctctgacatt gtcaccccac 2100 tgacgaggcc cgattccata gggtggatcc ttgccaggcg tccctgatcc tccctgccca 2160 agtcttcctt cgtgagctgg ccttgctccc catcccccaa gtgcctoaoc agtcccccag 2220 actgggtgaa ggtacagctg gctcotttcg ggggtgcagc ttcaactctc tcggcggtag 2280 ggcggtgcca tccccaccca tagggctggc tcacatccag tcactcccaa cagcgtccag 2340 cacacaaata aaagaccctt gggccotggc tctgagaaaa aaaa 2384 <210> 260 <211> 1500

<212> DNA <213> Homo sapiens <400> 260 agaotgccga gcagccttga gccgttgago agctgaacag aggccatgcc ggggcactcc 60 gaggcctgag acgaccacgc ctgtgccgct gaggaocttc atcagggctc cgtccacttg 120 goccgcttgg ctgtccaatc acactccagt gtcaaccact ggcaccoago agccaagaga 180 ggtgtggcgt ggccctgggg acgcatggct gaggcaggaa caggtgagcc gtcccccagc 240 gtggagggcg aacaogggac ggagtatgac acgctgcctt ccgacacagt ctccctcagt 300 gactcggact ctgacctcag cttgcccggt ggtgctgaag tggaagcact gtcoccgatg 360 gggctgcctg gggaggagga ttcaggtcct gatgagccgc cctcaccccc gtcaggcctc 420 ctcccagcca cggtgcagcc attccatctg agaggcatga gctccacctt ctoccagcgc 480 agccgtgaca tctttgactg cctggagggg gcggccagac gggctccatc ctctgtggcc 540 cacaccagca tgagtgacaa cggaggcttc aagcggcccc tagcgccctc aggccggtct 600 ccagtggaag gcctgggcag ggcccatcgg agccctgcct caccaagggt gcctccggtc 660 cccgactacg tggcacaccc cgagcgctgg accaagtaca gcctggaaga tgtgaccgag 720 gtcagcgagc agagcaatca ggccaccgcc ctggccttcc tgggctccca gagcctggct 780 gcccccactg actgcgtgtc ctccttcaac caggatccct ccagctgtgg ggaggggagg 840 gtcatcttca coaaacoagt ccgaggggtc gaagccagac acgagaggaa gagggtccrg 900 gggaaggtgg gagagcoagg caggggcggc cttgggaatc ctgccacaga caggggcgag 960 ggccctgtgg agctggcoca tctggccggg cccgggagcc cagaggctga ggagtggggc 1020 agcccccatg gaggcctgca ggaggtggag gcactgtcag ggtctgtcca cagtgggtct 1080 gtgccaggtc toccgccggt ggaaactgtt ggcttccatg gcagcaggaa gcggagtcga 1140 gaccacttcc ggaacaagag cagcagcccc gaggacccag gtgctgaggt ctgagaggga 1200 gatggcccag cctgacocca ctggccaotg ccatcctgct gccttcocag tggggctggt 1260 cagggggcag cctggccact gcctagctgg aatgggagga agcctgcagg tggcaccggt 1320 ggccctggct gcagttctgg gcagcatcet cccaagcaga gaccttgctg aagctcctgg 1380 ggtgtggggt gtgggotgga agcactggct ccotggtagg gacaataaag gttttgggtc 1440 tttcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaac 1500

<210> 261 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 261 tcatcttcac caaaccagtc cgaggggtcg aagccagaca cgagaggaag agggtcctgg 60

<210> 262 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 262 ctctgctcct gctcctgcct gcatgttctc tctgttgttg gagcctggag ccttgctctc 60

<210> 263 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 263 tgctcccggc tgtcctcctc tcctcttccc tagtgagtgg ttaatgagtg ttaatgccta 60

<210> 264 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 264 ccccatctct aaaaccagta aatcagccag cgaatacccg gaagcaagat gcacaggcgg 60

<210> 265 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 265 ccagaaacaa ggaagaggaa agacaaaggg aagggacggg agccctggag aagcccgacc 60

<210> 266 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 266 aagtacaacc catgctgcta agatgcgagc aggaagaggc atcctttgct aaatcctgtt 60 <210> 267 <211> 60

<212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 267 acctcacccc tgcccggccc aagctctact tgtgtacagt gtatattgta taatagacaa 60

<210> 268 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> Synthetic construct - oligonucleotide <400> 268 ttcccttaat tcctcctccc gacctttttt acccccccag ttgcagtatt taactgggct 60 60506771v1

REFERENCES CITED IN THE DESCRIPTION

This list of references cited by the applicant is for the reader's convenience only. It does not form part of the European patent document. Even though great care has been taken in compiling the references, errors or omissions cannot be excluded and the EPO disclaims all liability in this regard.

Patent documents cited in the description • US577084Q4P fOG391 • US50408703P [00841 • US10727.10QB [0084] . US10773761B [00841 • US062857A [00341 • US29884701P [0084] • US60257801P [0084] • US60577084 B [0171]

Non-patent literature cited in the description • ALTSCHUL et al.J. Mol. Biol., 1990, vol. 215, 403-410100231 • DEVITOHELLMANROSENBERGCancer, Principles and Practice of Oncology [00361

Claims (14)

1. Fremgangsmåde til klassificering af en celleholdig prøve som indeholdende tumorceller af en vævstype, hvilken fremgangsmåde omfatter bestemmelse af ekspressionsniveauerne for 50 eller flere transskriberede sekvenser i celler af en celleholdig prøve opnået fra et humant individ, og klassificering af prøven som indeholdende tumorceller af én eller flere af en flerhed af kendte tumortyper ved sammenligning af ekspressionsniveauerne af sekvenserne i cellerne med ekspressionsniveauerne af sekvenserne i flerheden af kendte tumortyper, hvor de 50 eller flere transskriberede sekvenser er vilkårligt udvalgt, hvor klassificeringen sker ved anvendelse af en afstandsbaseret klassifikationsalgoritme, og hvor flerheden af kendte tumortyper er udvalgt fra epithel, ikke-epithel, kimcelle, sarkom, binyre, hjerne, bryst, tyndtarmscancer, cervix (pladeepitelcelle), kolan-giokarcinom, endometrium, GIST (gastrointestinal stromatumor), nyre, leiomyo-sarkom, lever, lunge (adenokarcinom, storcellet), lunge (småcellet), lunge (pladeepitel), lymfom (B-celle), lymfom (Hodgkins), meningiom, mesotheliom, oste-osarkom, ovarie (clear cell), ovarie (serøs celle), pancreas, prostata, hud (basalcelle), hud (melanom), tynd- og tyktarm; blødt væv (liposarkom); blødt væv (MFH eller malignt fibrøst histiocytom), blødt væv (sarkom-synovial), skjoldbruskkirtel (follikulær-papillær), skjoldbruskkirtel (medullært karcinom) og urinblære.

2. Fremgangsmåde ifølge krav 1, hvilken fremgangsmåde endvidere omfatter bestemmelse af ekspressionsniveauerne af et supplerende antal transskriberede sekvenser, hvilke ekspressionsniveauer ikke anvendes i klassificeringen.

3. Fremgangsmåde ifølge krav 2, hvor ekspressionsniveauerne bestemmes ved anvendelse af et mikroarray.

4. Fremgangsmåde ifølge krav 1, 2 eller 3, hvor de 50 eller flere transskriberede sekvenser omfatter én eller flere udvalgt fra sættet af 74 gensekvenser identificeret i tabel 1; eller sættet af 90 gensekvenser identificeret i tabel 1 og ved SEQ ID NO: 149-200; eller sættet af 126 gensekvenser i en kombination af de 74 gensekvenser og de 90 gensekvenser.

5. Fremgangsmåde ifølge krav 4, hvor de 50 eller flere transskriberede sekvenser omfatter fem eller flere udvalgt fra sættet af 74 gensekvenser eller sættet af 90 gensekvenser eller sættet af 126 gensekvenser.

6. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 6, hvor bestemmelsen omfatter måling af ekspressionen af samtlige eller en del af de transskriberede sekvenser som et mRNA-molekyle.

7. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 7, hvor bestemmelsen omfatter amplifikation af samtlige eller en del af de transskriberede sekvenser, eller reverse transskription og markerende RNA svarende til de transskriberede sekvenser.

8. Fremgangsmåde ifølge krav 7, hvor amplifikationen omfatter lineær RNA-amplifikation eller kvantitativ PCR.

9. Fremgangsmåde ifølge krav 7, hvor amplifikationen er af sekvenser til stede i 600 nukleotider af polyadenyleringsstederne af de transskriberede sekvenser.

10. Fremgangsmåde ifølge krav 7, hvor amplifikationen er kvantitativ PCR-am-plifikation af mindst 50 nukleotider af de transskriberede sekvenser.

11. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 6, hvor prøven er en klinisk prøve fra en human patient.

12. Fremgangsmåde ifølge krav 11, hvor prøven er en formalinfikseret, paraffin-indlejret (FFPE) prøve.

13. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 6, hvor den cel-leholdige prøve er opnået fra et humant individ mistænkt for at være ramt af, eller med risiko for at udvikle, cancer; eller er en sektion af en celleholdig prøve; eller celler isoleret fra en celleholdig prøve; eller en frisk prøve; eller en frossen prøve; eller et aspirat; eller en cytologisk prøve; eller en prøve fremstillet ved duktal vask; eller en kanylebiopsi.

14. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 6, hvor den afstandsbaserede klassifikationsalgoritme er k-nearest neighbor- (KNN) algoritmen eller support vector machine- (SVM) algoritmen.