DK173684A - Bicylooxyarylthiourinstoffer og fremgangsmaade til fremstilling heraf - Google Patents

Bicylooxyarylthiourinstoffer og fremgangsmaade til fremstilling heraf Download PDF

Info

Publication number
DK173684A
DK173684A DK173684A DK173684A DK173684A DK 173684 A DK173684 A DK 173684A DK 173684 A DK173684 A DK 173684A DK 173684 A DK173684 A DK 173684A DK 173684 A DK173684 A DK 173684A
Authority
DK
Denmark
Prior art keywords
ring
carbocyclic
membered
substituents
alkyl
Prior art date
Application number
DK173684A
Other languages
English (en)
Other versions
DK173684D0 (da
Inventor
Paul Alfred Cain
Original Assignee
Union Carbide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Carbide Corp filed Critical Union Carbide Corp
Publication of DK173684D0 publication Critical patent/DK173684D0/da
Publication of DK173684A publication Critical patent/DK173684A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/38—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. nitrodiphenyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
    • C07C335/26—Y being a hydrogen or a carbon atom, e.g. benzoylthioureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)

Description

ring med op til to oxygen-, svovl- eller nitrogenatomer eller en kombination deraf, og hvor denne ring kan indeholde op til fire Y-substituenter, hvor Y hver er halogen, cyano eller alkyl, poly-halogenalkyl, alkoxv, polyhalogenalkyloxv, alkylsulfenvl eller nolyhalogenalkvlsulfenyl med 1-6 carbonatomer, B er et bicvclisk annelleret ringsystem, der er knyttet til oxygenet via en carbocyclisk ring, og hvor (a) mindst én ring er 6-leddet, umættet og carbocyclisk og indeholder sub-1 2 stituenterne R og R , (b) den anden ring, herefter også omtalt som A, når den ikke er en 5- eller 6-leddet mættet eller umættet carbocyclisk ring, kan være en 5- eller 6--leddet mættet eller umættet heterocvclisk ring, der i en hvilken som helst kombination kan indeholde en carbonvlgruppe eller et eller to oxygen- eller svovlatomer og sub- η i* stituenterne R-3 og Rfl bundet til umættede ringcarbonatomer eller substituenterne R^ og R6 bundet til mættede ringcarbonatomer, 1 2 R og R hver kan være hydrogen, halogen, nitro, cyano, amino, formamido, formamidino, phenyl-sulfenyl, phenvlsulfinyl, phenvlsulfonyl, phe-nylsulfamido eller phenoxysulfonyl, hvor phenylringen eventuelt indeholder 1 eller flere substituenter, der er halogen, nitro eller alkyl, polyhalogenalky1, alkoxy eller polvhalogenalkoxy med 1-3 carbonatomer, eller R1 og R2 er hver alkyl, alkoxy, polvhalogenalky1, polyhalogenalkoxv, alkenyloxv, polvhalogen-alkenyloxv, alkvnyloxy, polyhalogenalkynyl-oxy, alkylsulfenyl, alkylsulfonyl, polvhalo-genalkylsulfenyl, alkylsulfinyl, mono- eller di-alkvlsulfamido, mono- eller di-alkylamino, alkylcarbonylamino, alkoxvcarbonylamino, mono- eller di-alkylaminocarbonvloxy, alkoxy-sulfonvl, polvhalogenalkyloxysulfonyl med op til 6 carbonatomer i hver alkylkæde, morphi-linosulfonyl eller gruppen SO^Na, R3 og R4 hver er hydrogen, halogen, nitro, cyano eller alkyl, polyhalogenalkyl, alkoxy, poly-halogenalkoxy, alkylsulfinvl, alkylsulfenyl, alkvlsulfonyl, alkoxvcarbonylamino eller alkylcarbonylamino med 1-8 carbonatomer, og r^ og R^ hver er hydrogen, alkyl eller polyhalogenalkyl med 1-6 carbonatomer eller phenyl, der eventuelt er substitueret med op til tre halogen,.cyano, nitro eller alkyl, polyhalogenalkyl, alkoxy eller polyhalogenalkoxy med op til tre carbonatomer, fremstilles ved forskellige fremgangsmåder.
Forbindelserne med formlen I anvendes som det aktive toksiske middel i pesticider.
DK173684A 1983-03-31 1984-03-30 Bicylooxyarylthiourinstoffer og fremgangsmaade til fremstilling heraf DK173684A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/480,697 US4665097A (en) 1983-03-31 1983-03-31 Novel bicyclooxyaryl thioureas and process for preparation

Publications (2)

Publication Number Publication Date
DK173684D0 DK173684D0 (da) 1984-03-30
DK173684A true DK173684A (da) 1984-10-01

Family

ID=23908972

Family Applications (1)

Application Number Title Priority Date Filing Date
DK173684A DK173684A (da) 1983-03-31 1984-03-30 Bicylooxyarylthiourinstoffer og fremgangsmaade til fremstilling heraf

Country Status (6)

Country Link
US (1) US4665097A (da)
EP (1) EP0124282B1 (da)
JP (1) JPS59184155A (da)
AT (1) ATE30019T1 (da)
DE (1) DE3466532D1 (da)
DK (1) DK173684A (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342958A (en) * 1970-05-15 1994-08-30 Solvay Duphar International Research B.V. Organic compounds derived from urea or thiourea
US5245071A (en) * 1970-05-15 1993-09-14 Duphar International Research B.V. Organic compounds derived from urea or thiourea
US5135953A (en) * 1984-12-28 1992-08-04 Ciba-Geigy Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals
OA12961A (en) 2002-11-19 2006-10-13 Achillion Pharmaceuticals Inc Substituted aryl thioureas and related compounds, inhibitors of viral replication.
TW200600492A (en) * 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
CN105530923B (zh) * 2013-09-09 2019-07-23 佩洛通治疗公司 芳基醚及其用途
US9884843B2 (en) 2013-12-16 2018-02-06 Peloton Therapeutics, Inc. Cyclic sulfone and sulfoximine analogs and uses thereof
WO2016144826A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Substituted pyridines and uses thereof
WO2016145032A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Compositions for use in treating pulmonary arterial hypertension
WO2016144825A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Aromatic compounds and uses thereof
US10512626B2 (en) 2015-03-11 2019-12-24 Peloton Therapeautics, Inc. Compositions for use in treating glioblastoma
US10335388B2 (en) 2015-04-17 2019-07-02 Peloton Therapeutics, Inc. Combination therapy of a HIF-2-alpha inhibitor and an immunotherapeutic agent and uses thereof
US9796697B2 (en) 2015-06-12 2017-10-24 Peloton Therapeutics, Inc. Tricyclic inhibitors of HIF-2-alpha and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL160809C (nl) * 1970-05-15 1979-12-17 Duphar Int Res Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen.
DE2059872A1 (de) * 1970-12-05 1972-06-15 Merck Patent Gmbh Thioharnstoffe,Verfahren zu ihrer Herstellung und ihre Verwendung zur Schaedlingsbekaempfung
US4160037A (en) * 1977-09-30 1979-07-03 The Upjohn Company Compounds, compositions and methods of combatting pest employing thioureas
ZA793186B (en) * 1978-07-06 1981-02-25 Duphar Int Res New urea and thiourea compounds, method of preparing the new compounds, as well as insecticidal compositions on the basis of these compounds
DE2837086A1 (de) * 1978-08-24 1980-03-06 Bayer Ag Substituierte n-phenyl-n'-benzoyl- thioharnstoffe, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
US4264605A (en) * 1978-08-31 1981-04-28 Eli Lilly And Company 1-Benzoyl-3-(aryloxy- or arylthiopyridinyl) urea compounds
GR73690B (da) * 1979-01-15 1984-04-02 Celamerck Gmbh & Co Kg
ZA801680B (en) * 1979-04-03 1981-03-25 Fujisawa Pharmaceutical Co 2-imidazoline derivatives,process for the preparation thereof and the pharmaceutical composition of the same
AU532156B2 (en) * 1979-09-07 1983-09-22 Ishihara Sangyo Kaisha Ltd. N-benzoyl-n'-pyridyloxy phenyl urea
US4426385A (en) * 1980-10-16 1984-01-17 Union Carbide Corporation Insecticidal bicyclooxyphenyl ureas
EP0052833B1 (de) * 1980-11-22 1983-12-14 CELAMERCK GmbH &amp; Co. KG Harnstoffderivate, ihre Herstellung und Verwendung
US4468405A (en) * 1981-07-30 1984-08-28 The Dow Chemical Company Substituted N-aroyl N'-phenyl urea compounds
DE3217620A1 (de) * 1982-05-11 1983-11-17 Bayer Ag, 5090 Leverkusen 2,5-dihalogenbenzoyl-(thio)harnstoffe, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel

Also Published As

Publication number Publication date
EP0124282B1 (en) 1987-09-30
DK173684D0 (da) 1984-03-30
EP0124282A1 (en) 1984-11-07
ATE30019T1 (de) 1987-10-15
DE3466532D1 (en) 1987-11-05
US4665097A (en) 1987-05-12
JPS59184155A (ja) 1984-10-19

Similar Documents

Publication Publication Date Title
DK173684A (da) Bicylooxyarylthiourinstoffer og fremgangsmaade til fremstilling heraf
CO5070570A1 (es) DERIVADOS DE TIROSINA COMO ACTIVADORES DE hPPAR Y hPPARalfa Y UNA COMPOSICION FARMACEUTICA QUE LOS CONTIENE
DK51986A (da) Heterocycliske forbindelser, deres fremstilling og anvendelse som insecticide midler
NO865303L (no) Nitrogenholdige heterocykliske forbindelser.
SE8201145L (sv) Nya aminometyl-5 oxazolidiniska derivat, deras framstellningssett och derasterapeutiska anvendning
ES525122A0 (es) Procedimiento para preparar derivados de piridina
AR247070A1 (es) Composicion biocida que contiene una isotiazolinona y una urea
BR9303993A (pt) Composto, processo para preparar o mesmo e composição farmacêutica
NO155243C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive kinazolinderivater.
DK502781A (da) Fremgangsmaade til fremstilling af 3-aryloxy-3-phenylpropylaminer
ES2096560T3 (es) Compuestos de benzocicloheptapiridina sustituida con fluor, composiciones y metodos para uso como compuestos antihistaminicos.
MX9203249A (es) Derivados del acido bencimidazolin-2-oxo-1-carboxilico y composiciones farmaceuticas que los contienen.
AR014868A1 (es) UN COMPUESTO DERIVADO DE N,N ( SUSTITUIDO) FENIL (ARILO O HETEROARILO) PROPANAMINA, UNA COMPOSICIoN FARMACÉUTICA, USO DE DICHO COMPUESTO Y UN MÉTODO PARA PREPARARLO.
DK158469C (da) Substituerede 1-hydroxyethyl-triazolyl-derivater, deres anvendelse som plantebeskyttelsesmidler og fungicider, fremgangsmaade til fremstilling af de fungicide midler samt oxiraner til anvendelse som mellemprodukter ved fremstilling af de naevnte forbindelser
DK448080A (da) Substituerede urinstoffer fremgangsmaade til fremstilling deraf anvendelse deraf som herbicider og herbicider til brug herved
MA21781A1 (fr) Esters ((1,3,5,-triazine-2-yl) aminocarboxyl)-aminosulfonyl) benzoiques herbicides, procedes pour leur preparation et leur utilisation .
CO4650018A1 (es) Nuevas composiciones herbicidas que comprenden una mezcla de 4-benzoilisoxazoles y compuestos herbicidas de 2,6-dinitro- anilina
DK452784A (da) N-(thio)carbamoylaryl(thio)carboximidsyreestere, fremgangsmaade tilderes fremstilling, midler indeholdende dem og deres anvendelse som skadedyrsbekaempelsesmidler
ES555820A0 (es) Procedimiento para la obtencion de 1-aril-5-alcoxiiminoalquilamino-pirazoles
FI854171A0 (fi) 1,4-dihydropyridin-hydroxiaminer, foerfarande foer deras framstaellning saovael som deras anvaendning som laekemedel.
FI915980A (fi) Alkylaminoalkylamin- och eter- foereningar samt foerfaranden och mellanprodukter foer deras framstaellning och laekemedel som innehaoller dessa foereningar.
ATE20062T1 (de) Benzamide, ihre salze, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
GB2010824A (en) 4-amino-6,7-dialkoxy-2- substituted quinazolines
SE8405450L (sv) 1,4-dihydropyridinderivat, framstellning derav och farmaceutiska beredningar innehallande dessa
ES2143453T3 (es) Uso de derivados de dihidropiridina para la profilaxis o el tratamiento de trastornos de la circulacion cerebral.

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment
B1 Patent granted (law 1993)