DK166884A - Pyrimidinderivater - Google Patents
Pyrimidinderivater Download PDFInfo
- Publication number
- DK166884A DK166884A DK166884A DK166884A DK166884A DK 166884 A DK166884 A DK 166884A DK 166884 A DK166884 A DK 166884A DK 166884 A DK166884 A DK 166884A DK 166884 A DK166884 A DK 166884A
- Authority
- DK
- Denmark
- Prior art keywords
- pyrimidine
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838308290A GB8308290D0 (en) | 1983-03-25 | 1983-03-25 | Pyrimidinone derivatives |
| GB8308290 | 1983-03-25 | ||
| GB8315542 | 1983-06-07 | ||
| GB838315542A GB8315542D0 (en) | 1983-06-07 | 1983-06-07 | Pyrimidinone derivatives |
| GB838327859A GB8327859D0 (en) | 1983-10-18 | 1983-10-18 | Pyrimidine derivatives |
| GB8327859 | 1983-10-18 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK166884D0 DK166884D0 (da) | 1984-03-23 |
| DK166884A true DK166884A (da) | 1984-09-26 |
| DK160492B DK160492B (da) | 1991-03-18 |
| DK160492C DK160492C (da) | 1991-08-26 |
Family
ID=27262023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK166884A DK160492C (da) | 1983-03-25 | 1984-03-23 | Pyrimidinderivater, fremgangsmaader til fremstilling heraf samt farmaceutiske praeparater indeholdende disse derivater |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US4612376A (da) |
| EP (1) | EP0123402B1 (da) |
| KR (1) | KR840008333A (da) |
| CA (1) | CA1256107A (da) |
| DE (1) | DE3473875D1 (da) |
| DK (1) | DK160492C (da) |
| ES (2) | ES530916A0 (da) |
| FI (1) | FI841128A7 (da) |
| GR (1) | GR81758B (da) |
| HU (1) | HU195195B (da) |
| NO (1) | NO841168L (da) |
| PH (1) | PH22022A (da) |
| SU (2) | SU1349698A3 (da) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4612376A (en) * | 1983-03-25 | 1986-09-16 | Fujisawa Pharmaceutical Co., Ltd. | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent |
| US4598149A (en) * | 1984-03-02 | 1986-07-01 | Merck & Co., Inc. | 3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihypertensive, cardioprotective, antiarrythmic, and antianginal agents |
| US4649142A (en) * | 1984-06-25 | 1987-03-10 | Fujisawa Pharmaceutical Co., Ltd. | 3,4-dihydro-1,3-disubstituted-6-(substituted phenylimino)-2(1H)-pyrimidinone useful as cardiotonic agent and anti-allergic agent |
| US4708958A (en) * | 1986-09-24 | 1987-11-24 | G. D. Searle & Co. | 6-(imidazolyphenyl)-4-iminopyrimidinones useful as hypotensive agents |
| US5521315A (en) * | 1993-01-12 | 1996-05-28 | Cell Therapeutics, Inc. | Olefin substituted long chain compounds |
| IT1270122B (it) * | 1994-10-04 | 1997-04-28 | Ist Superiore Sanita | 6-benzil-4-ossopirimidine sostituite, processo per la loro preparazione e composizioni farmaceutiche che le contengono |
| DE69630799T2 (de) * | 1995-09-06 | 2004-08-12 | Kowa Co., Ltd., Nagoya | Pyrimidinderivate |
| US6244121B1 (en) * | 1998-03-06 | 2001-06-12 | Applied Materials, Inc. | Sensor device for non-intrusive diagnosis of a semiconductor processing system |
| KR101078098B1 (ko) | 2003-01-14 | 2011-10-28 | 아레나 파마슈티칼스, 인크. | 대사 조절제로서의 １,２,３-삼치환된 아릴 및 헤테로아릴유도체, 및 당뇨병 및 고혈당증을 비롯한 이에 관련된장애의 예방 및 치료 |
| AR045697A1 (es) | 2003-07-14 | 2005-11-09 | Arena Pharm Inc | Aril y heteroaril derivados fusionados como moduladores del metabolismo y la prevencion y tratamiento de trastornos relacionados con el mismo |
| DOP2006000009A (es) | 2005-01-13 | 2006-08-15 | Arena Pharm Inc | Procedimiento para preparar eteres de pirazolo [3,4-d] pirimidina |
| KR101577554B1 (ko) | 2005-08-22 | 2015-12-14 | 멜리어 파마슈티칼스 아이, 인코포레이티드 | Ｌｙｎ 키나제 활성의 조절 및 관련된 장애의 치료를 위한 방법 및 제제 |
| CN101686686A (zh) * | 2007-02-20 | 2010-03-31 | 梅里奥尔医药I公司 | 鉴别Lyn激酶激活剂的方法 |
| JP2010534668A (ja) * | 2007-07-23 | 2010-11-11 | メリオール・ディスカヴァリー・インコーポレイテッド | Ｉｒｓ−１及びａｋｔを活性化する方法 |
| US8552184B2 (en) * | 2008-07-03 | 2013-10-08 | Melior Pharmaceuticals I, Inc. | Compounds and methods for treating disorders related to glucose metabolism |
| EP2462123B1 (en) * | 2009-08-04 | 2013-10-02 | Merck Sharp & Dohme Corp. | 4,5,6-trisubstituted pyrimidine derivatives as factor ixa inhibitors |
| CN108558740B (zh) | 2010-01-27 | 2021-10-19 | 艾尼纳制药公司 | S1p1受体调节剂及其盐的制备方法 |
| WO2011150300A1 (en) | 2010-05-28 | 2011-12-01 | Melior Pharmaceuticals I, Inc. | Prevention of pancreatic beta cell degeneration |
| SG188548A1 (en) | 2010-09-22 | 2013-04-30 | Arena Pharm Inc | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| US10183949B2 (en) | 2014-08-29 | 2019-01-22 | The University Of Tokyo | Pyrimidinone derivative having autotaxin-inhibitory activity |
| EP3187492A4 (en) * | 2014-08-29 | 2018-05-09 | The University of Tokyo | Pyrimidinone derivative having autotaxin-inhibitory activity |
| PL3242666T3 (pl) | 2015-01-06 | 2025-02-17 | Arena Pharmaceuticals, Inc. | Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1 |
| HUE060476T2 (hu) | 2015-06-22 | 2023-03-28 | Arena Pharm Inc | (R)-2-(7-(4-ciklopentil-3-(trifluormetil)benziloxi)-1,2,3,4- tetrahidrociklopenta[B]indol-3-il)ecetsav kristályos L-arginin-sója S1P1 receptorral kapcsolatos rendellenességek esetén való alkalmazásra |
| WO2018151873A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
| MX387305B (es) | 2017-04-10 | 2025-03-18 | Melior Pharmaceuticals I Inc | Tratamiento de adipocitos |
| US12156866B2 (en) | 2018-06-06 | 2024-12-03 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
| CN109053589A (zh) * | 2018-09-30 | 2018-12-21 | 浙江师范大学 | 4-亚胺基四氢嘧啶-2-酮类化合物的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1296371A (da) * | 1969-02-26 | 1972-11-15 | ||
| AU1108070A (en) * | 1969-03-06 | 1971-08-12 | Imperial Chemical Industries Limited | Pyrimidine derivatives |
| GB1336138A (en) * | 1969-12-10 | 1973-11-07 | Ici Ltd | Process for the production of pyrimidine derivatives |
| US3923807A (en) * | 1973-09-10 | 1975-12-02 | Takeda Chemical Industries Ltd | 6-Aminouracil derivatives |
| US4208366A (en) * | 1978-10-31 | 1980-06-17 | E. I. Du Pont De Nemours And Company | Process for preparing a nonwoven web |
| DE2847693A1 (de) * | 1978-11-03 | 1980-05-22 | Hoechst Ag | Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen |
| US4612376A (en) * | 1983-03-25 | 1986-09-16 | Fujisawa Pharmaceutical Co., Ltd. | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent |
-
1984
- 1984-03-12 US US06/588,902 patent/US4612376A/en not_active Expired - Fee Related
- 1984-03-14 EP EP84301741A patent/EP0123402B1/en not_active Expired
- 1984-03-14 PH PH30400A patent/PH22022A/en unknown
- 1984-03-14 GR GR74104A patent/GR81758B/el unknown
- 1984-03-14 DE DE8484301741T patent/DE3473875D1/de not_active Expired
- 1984-03-20 KR KR1019840001414A patent/KR840008333A/ko not_active Ceased
- 1984-03-21 CA CA000450076A patent/CA1256107A/en not_active Expired
- 1984-03-21 FI FI841128A patent/FI841128A7/fi not_active Application Discontinuation
- 1984-03-23 SU SU843718401A patent/SU1349698A3/ru active
- 1984-03-23 NO NO841168A patent/NO841168L/no unknown
- 1984-03-23 HU HU841170A patent/HU195195B/hu not_active IP Right Cessation
- 1984-03-23 DK DK166884A patent/DK160492C/da active IP Right Grant
- 1984-03-23 ES ES530916A patent/ES530916A0/es active Granted
- 1984-11-30 ES ES538190A patent/ES538190A0/es active Granted
-
1985
- 1985-03-28 SU SU853892541A patent/SU1436872A3/ru active
-
1986
- 1986-06-05 US US06/870,826 patent/US4746664A/en not_active Expired - Fee Related
-
1988
- 1988-03-25 US US07/173,584 patent/US4824851A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES8601922A1 (es) | 1985-11-01 |
| DK160492C (da) | 1991-08-26 |
| FI841128A7 (fi) | 1984-09-26 |
| ES8505972A1 (es) | 1985-06-16 |
| ES530916A0 (es) | 1985-06-16 |
| EP0123402A3 (en) | 1985-09-18 |
| NO841168L (no) | 1984-09-26 |
| FI841128A0 (fi) | 1984-03-21 |
| EP0123402A2 (en) | 1984-10-31 |
| SU1349698A3 (ru) | 1987-10-30 |
| DK160492B (da) | 1991-03-18 |
| KR840008333A (ko) | 1984-12-14 |
| CA1256107A (en) | 1989-06-20 |
| ES538190A0 (es) | 1985-11-01 |
| EP0123402B1 (en) | 1988-09-07 |
| DK166884D0 (da) | 1984-03-23 |
| US4824851A (en) | 1989-04-25 |
| DE3473875D1 (en) | 1988-10-13 |
| PH22022A (en) | 1988-05-13 |
| US4746664A (en) | 1988-05-24 |
| GR81758B (da) | 1984-12-12 |
| SU1436872A3 (ru) | 1988-11-07 |
| HU195195B (en) | 1988-04-28 |
| US4612376A (en) | 1986-09-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO845017L (no) | Hoeyspennings-koplingsstykke | |
| DK298784A (da) | Kobber-leder-praeparater | |
| DK158553C (da) | Vaeskecarboniseringsapparat | |
| DK166884D0 (da) | Pyrimidinderivater | |
| DK563483D0 (da) | Dampspaerre | |
| DK327985A (da) | Pyrimidinderivater | |
| DK309084A (da) | Aminopyrimidinderivater | |
| DK310184D0 (da) | Spirosuccinimider | |
| DK328385A (da) | Motorsavsvaerd | |
| DK328484D0 (da) | Depot-antiphlogistika | |
| DK48584A (da) | N-piperazinylalkanoylanilider | |
| DE3379173D1 (de) | Photoradiator | |
| ES278367Y (es) | Presentador-distribuidor | |
| DK198784D0 (da) | Pyrimidonderivater | |
| DK153567C (da) | Stabelbar petriskaal | |
| DK625084D0 (da) | Gonadoliberinderivater | |
| AT377349B (de) | Lusterbehang | |
| DK598683A (da) | Inertidaemper | |
| DK510484A (da) | Substituerede pyrimidiner | |
| DK171884A (da) | Gonadoliberinderivater | |
| AT386759B (de) | Schlagmuehle | |
| ATA160983A (de) | Beschlag | |
| DK572584D0 (da) | Boelgevirkningsgenerator | |
| DK5284D0 (da) | Penemestere | |
| DD219060A3 (de) | Absorptionswaermepumpe |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed | ||
| B1 | Patent granted (law 1993) |