DK166654B1 - THE CONTACT LENS CLEANING SITE WITH TWO TREATMENTS - Google Patents

Description

DK 166654 B1

The invention relates to a contact lens cleaning kit with two treatment agents, one of which is a sterilizing hydrogen peroxide and the other an enzyme catalyst-containing neutralizing agent for neutralizing and decomposing the hydrogen peroxide after sterilizing a contact lens.

Cleansing kits for soft and hard contact lenses serve to cleanse and disinfect, as well as to stabilize the optical properties and to enhance user convenience. Hydr-10 ogen peroxide has become important as an antimicrobial agent for disinfecting and cleaning contact lenses. Compared to chlorhexidine salts or organo-mercury compounds such as thiomersal, which are also used to disinfect contact lenses, hydrogen peroxide has better antimicrobial effect, especially in the relatively resistant Aspergillus species.

The known hydrogen peroxide solutions used to purify contact lenses are 3% peroxide solutions (German Patent No. 2,425,714). After treating the contact lenses with these solutions, relatively large residual amounts of hydrogen peroxide solution are adhered to the lenses. When the lenses thus treated are applied to the eye, these residual amounts lead to varying degrees of irritation of the eye's mucosa. Therefore, after treatment with hydrogen peroxide solution, it is necessary to treat the lenses with a neutralizing solution by which the hydrogen peroxide is decomposed into water and oxygen. The elimination after sterilization of residual amounts of hydrogen peroxide by decomposition by means of especially heavy metal catalysts is known from the above mentioned German patent. Here it is necessary to use two different processing steps, namely first sterilization of the lens and then elimination of the residual hydrogen peroxide in an aqueous system containing the catalyst. The handling of the lenses and the disinfection and cleansing is therefore relatively complicated. The choice of suitable catalysts used for the decomposition of the residual amounts of hydrogen peroxide also presents difficulties.

2 DK 166654 B1

As catalysts for decomposing the hydrogen peroxide after use, it is known to use enzymatic peroxidases, in particular catalase from EP-A-82 798. However, in this case, however, the hydrogen peroxide solution is poured after the disinfection treatment and replaced with a neutralizing solution containing the peroxide neutralizing catalyst, e.g. peroxidase. Here, too, two consecutive treatment steps are required, which makes the cleaning operation relatively complicated.

In both cases, it is impossible to treat a contact lens while using hydrogen peroxide and a neutralizing solution with a decomposition catalyst, because then the hydrogen peroxide is decomposed to oxygen and water by the neutralizing solution with the decomposition catalyst before it has sufficient sterilizing effect to eliminate all germs on the lenses, requiring 1-4 hours, especially in the case of soft lenses.

20 EP patent specification No. 139,994 discloses a contact lens sensing kit which utilizes hydrogen peroxide and also a tablet containing a compound which can neutralize hydrogen peroxide and which is provided with a coating which dissolves only after a certain time. As the hydrogen peroxide neutralizing compound are used compounds which, after neutralizing the hydrogen peroxide, contribute to the formation of a buffered lens storage solution and are consequently ionic compounds. It is further stated in EP Patent No. 139,994 that the use of catalytic neutralizing compounds, e.g. peroxidase / catalase enzyme is partly expensive and partly does not contribute to the formation of a buffered lens storage solution. Thus, EP Patent No. 139,994 represents a prejudice against the use of enzyme catalysts in contact lens cleaning kits.

35 3 DK 166654 B1

The object of the invention is to provide a contact lens cleaning kit which in a single step holds hydrogen peroxide in active form for a sufficient period of time to sterilize the lenses and which then neutralizes the residual amount of hydrogen and peroxide on the lenses so that the lenses can then be worn without disadvantages.

This object is achieved with the contact lens cleaning kit set forth in the claims and the aforementioned prejudice is overcome.

10

To this end, the invention provides a contact lens cleaning kit with two treatment agents: namely hydrogen peroxide and a neutralizing agent containing an enzyme catalyst. The hydrogen peroxide is sufficient to sterilize a hard or soft contact lens or both. The neutralizing agent is sufficient to decompose any residual amount of the hydrogen peroxide on the oxygen and water lenses after the hydrogen peroxide has sterilized the lenses so that they can be worn without disadvantage. The neutralizing agent 20 contains an enzyme catalyst and a neutralizing agent to decompose the residual amount of hydrogen peroxide and is combined with a delay agent. The delay agent delays the time of release of the neutralizing agent until the hydrogen peroxide has sterilized the lenses.

Accordingly, the contact lens cleaning kit of the invention is peculiar in that the neutralizing agent and / or enzyme catalyst which decomposes the hydrogen peroxide is combined with a delay agent which regulates the delayed release.

The invention therefore facilitates the erection of the contact lenses, which may be hard or soft because only a single step is required. The lenses and the neutralizing agent with the enzyme catalyst and the delaying agent are placed in a sterilizing solution of hydrogen peroxide. The delay agent, 4 contacting the hydrogen peroxide during the immersion, then releases at least a neutralizing amount of the enzyme catalyst-containing neutralizing agent after the hydrogen peroxide has acted on the contact lenses for a sufficient time for sterilization.

For this purpose, the neutralizing agent may be coated with the delay agent for immersion in an aqueous hydrogen peroxide solution together with the lenses. The delayed release 10 can be adjusted, especially for up to four hours, by the thickness of the coating dissolved in the hydrogen peroxide solution. As a result of the release of the enzyme catalyst-containing neutralizing agent by the coating solution, the neutralizing agent operates automatically without further user intervention. The hydrogen peroxide solution is acidic (with a pH below 4) in the stable state to obtain both sterilization and solution. The enzyme catalyst located within the coating then decomposes the sterilizing hydrogen peroxide solution into a treatment vessel in which the lenses and the neutralizing agent have been placed at the same time.

Examples of the composition of the hydrogen peroxide solution and of the enzyme catalyst-containing neutralizing agent are given in German Publication No. 3,410,400.

Furthermore, the following composition is suitable for the neutralizing agent:

0.05 wt% catalase concentrate, 260,000 units / ml 0.05 wt% hydroxypropyl methyl cellulose USP XX

0.05% by weight of NaH2PO4, 2H20 DAB 8 0.25% by weight Na2HPO4, 2H20 0.75% by weight sodium chloride EP I

In the following, a further appropriate composition of the neutralizing agent is indicated: 3-12 mg of suitable buffer, e.g. alkali metal phosphate, borate or citrate, glycine 40-70 mg of neutral electrolyte (eg NaCl, KCl) 5-10 mg of alkali metal hydrogen carbonate 5-10 mg of water-soluble polymer, e.g. polyvinylpyrrolidone 0.2-1 mg enzyme catalyst (catalase, peroxidase) per single dose.

This amount is sufficient for decomposition, for neutralization and for control to an osmolarity of 270-320 moles of 7 ml of a hydrogen peroxide solution. These 7 ml correspond to the volume of a standard contact lens container or contact lens treatment container.

An example of a further particular composition of the neutralizing agent is as follows: 5.6 mg potassium hydrogen phosphate 8 mg disodium hydrogen phosphate 52.4 mg NaCl 20 7 mg sodium bicarbonate 4.8 mg polyvinylpyrrolidone K25 0.3 mg enzyme catalyst

The above composition of the neutralizing agent 25 is used as capsule filling, the capsule being designed as the delay agent surrounding the enzyme catalyst-containing neutralizing agent. The capsule comprises a water-soluble polymer, especially a polyvinyl alcohol.

The neutralizing agent may also be formed into a tablet which is provided with a water-soluble coating which causes delayed dissolution of the tablet. The water-soluble coating may comprise a polymer which is soluble in an acidic medium, such as a polymer of dimethylaminomethacrylate and neutral methacrylic esters. The coating may also comprise a pH-neutral soluble polymer. Polymers suitable for this purpose, e.g. soluble cellulose ethers such as methyl cellulose, methyl hydroxypropyl cellulose, methyl hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl cellulose, cellulose acetate phthalate, hydroxypropyl methyl acetate acetate, aqueous dispersion of cellulose acetate phthalate, copolymer of methyl vinyl ether and maleic anhydride, and polyvinyl yl alcohols.

Suitable polyalcohols, especially in an amount of 0.2-1 mg per liter. tablet, can be added to these polymers to control the delay. For this purpose, especially 1,2-propylene glycol, 15 polyethylene glycols and citrate esters are suitable.

The coating may be prepared from the water-soluble polymer using well known methods, e.g. by spraying a film into a coating container, by fluidization (Wurster method) or in closed systems. The preferred amount of polymer for coating a tablet is 2.0 to 5.0 mg.

Below is an example of a tablet composition 25 which is the enzyme catalyst-containing neutralizing agent: 11.2 mg disodium hydrogen phosphate 55.8 mg NaCl 4.8 g polyvinylpyrrolidone K25 0.2 mg enzyme catalyst (catalase, peroxidase) 30

Below is an example of an acid-soluble polymer suitable as a coating: 1.9 mg methacrylate ester 0.4 mg hydroxypropylmethylcellulose 35 0.2 mg polyethylene glycol (1000) 7 DK 166654 B1 o

Below is an example of a coating film of a polymer which is soluble in neutral environment: 2.2 mg hydroxypropylmethylcellulose phthalate 5 0.3 mg polyethylene glycol (1000)

It is also possible to seal an enzyme catalyst-containing neutralizing agent formed into a tablet with a water-soluble film of e.g. polyvinyl alcohol which acts as a delay agent. Plasticizers in the form of polyhydric alcohols and water are added in an amount of 3.5% -5% to the polyvinyl alcohol film, whereby a delayed solution of the film is obtained. The film can have a thickness of 30-150 μπι. The gas permeability (DIN 53,380) is 0.9-1.4 ml / m2 / <Vkar · The films 15 can be welded at temperatures of 140-190 ° C at a contact pressure of 4-5 bar.

The enzyme catalyst-containing neutralizing agent in the form of a tablet can also be coated with an insoluble, but 20 semipermeable membrane. This membrane can also be applied using known coating methods such as by spraying, by fluidization or in closed systems in an amount of 3-10 mg / ml. tablet. The semipermeable membrane can e.g. is formed from an organic solution of ethyl cellulose, an aqueous dispersion of ethyl cellulose, a copolymer of acrylate / methacrylate esters with trimethylammonium methacrylate, an aqueous dispersion of mixed methyl methacrylates and ethyl methacrylic 1-aates. To adjust the rate of diffusion, suitable plasticizers may be added, especially in an amount of 1.5-5.0 mg / ml. tablet. 1,2-propylene glycol, polyethylene glycols and citrate esters can be used as plasticizers. An example of the composition of a semi-permeable membrane is as follows: 3.8 mg ethylcellulose N22 1.2 mg polyethylene glycol (6,000) 35

A further example of a delay agent by which a delayed release of the enzyme catalyst which decomposes the hydrogen peroxide and of the neutralizing agent can be obtained is a swellable, yet highly soluble or insoluble matrix, especially in tablet form, wherein the enzyme catalyst-containing neutralizing agent is distributed. The enzyme catalyst-containing neutralizing agent, which may have any of the above compositions, is incorporated into the aforementioned matrix which may comprise natural or partially synthetic polymer. The particularly tablet-shaped matrix can be prepared by 10 conventional processes, e.g. by granulating and casting the starting materials. It is also possible to process the mixture of starting materials directly into tablets without prior granulation. Polymers suitable for forming the matrix are soluble cellulose ethers such as the aforementioned alkali metal salts of alginic acid, methacrylic acid derivatives, especially acrylate / methacrylate esters, acrylic acid derivatives, dextrans (molecular weight 1,000-75,000) and polyvinyl alcohols. Below is an example of a matrix incorporating the enzyme catalyst-containing neutralizing agent: 0.3 mg of enzyme catalyst (catalase, peroxidase) 10.2 mg of disodium hydrogen phosphate 55.8 mg of NaCl 4.7 mg of polyvinylpyrrolidone K25 25 mg of hydroxypropyl methylcellulose

Tablets with a weight of e.g. 86 mg and a diameter of 6 mm.

It is also possible to incorporate the enzyme catalyst and the neutralizing agent into a highly concentrated aqueous polymer solution, from which foils having a thickness of 1.0-3.0 mm can be prepared. By cutting the film to the desired size, suitable unit doses with predetermined surface dimensions can be prepared. The water-soluble polymers act as delay agents, thereby providing a delayed release of enzyme catalyst and neutralizing agent. Suitable polymers are water-soluble cellulose ethers such as the above, alkali metal alginates, dextranes and polyvinyl alcohols.

5

It is known in the administration of drugs to use therapeutic systems in the form of tablets, semipermeable membranes and matrices placed in specific target areas of a biosystem to obtain a constant release of the drug 10 over a prolonged period of time. In contrast, the present invention provides that the hydrogen peroxide decomposing enzyme catalyst together with the sterilizing hydrogen peroxide can be used at the same time to treat contact lenses without detrimental effect from the enzyme catalyst on the desired sterilization effect of the hydrogen peroxide for a period of e.g. . 4 hours. The disintegrating effect of the enzyme catalyst on the hydrogen peroxide starts only at the end of the desired treatment time.

A delayed release of the enzyme catalyst can also be achieved by immobilizing the enzyme catalyst on particulate carriers, especially acrylic resin particles, e.g. by binding by reactive oxirane groups. The carriers, together with the enzyme catalyst immobilized thereon, are applied in an appropriate amount, e.g. the bottom or lid of a threaded contact lens treatment container and separated from the treatment solution containing the pH neutralizing materials and neutral salts together with the hydrogen peroxide by permeable inert mesh webs. In this embodiment, the enzyme catalyst is placed in one portion of the treatment vessel without mixing with the treatment solution. In this way, the risk of the enzyme catalyst material being accumulated in the soft lenses during treatment of the lenses is avoided. Eg. can use an amount of 35 carrier with immobilized enzyme catalyst for 30 days of use. placed in the container part.

DK 166654 B1 10

The treatment solution in which the release of the enzyme catalyst-containing neutralizing agent takes place may have a pH of 7-7.5, especially 7.3 and an osmolarity of approx. 300 5 mosmol.

A color change, especially when using a color indicator (pH / redox indicator) which changes color at a pH of 7.0-7.5 and especially at 7.3, tells the user that the hydrogen peroxide used is 10 for the sterilization treatment, has been disintegrated. For this purpose, in particular, high molecular colors which do not penetrate the lens material are suitable.

In order for the enzyme catalyst to exert its effect only after the disinfection and sterilization treatment of the lenses, this enzyme catalyst additive, as well as the auxiliary materials present in the neutralizing agent, which serves to neutralize hydrogen peroxide, can be provided with a coating which ensures that the enzyme catalyst is used. -20 ling of the hydrogen peroxide is released only after the required treatment time of up to 4 hours. There are many ways to achieve this.

The coating on the enzyme catalyst and the auxiliary materials may take the form of a capsule which is water soluble at the pH at which the hydrogen peroxide solution is stable, i.e. at a pH value of 4-5 and which is not flocculated or precipitated in neutral solution, i.e. at a pH of 7.3.

It is further advantageous that the capsule has one or two or optionally several laser perforations through which the auxiliary materials are released upon contact with the hydrogen peroxide solution, the capsule dissolving completely when a pH of approx. 7 is reached for release of the enzyme catalyst at this time.

11 DK 166654 B1

The enzyme catalyst may also be present as enzyme granules or granules (prill) which, together with the auxiliary materials, are filled into the capsule having the aforementioned solubility properties.

5

The enzyme catalyst-containing neutralizing agent can also be formed into a coated tablet, from which - with the delayed solution of the coating - first of all, the auxiliary materials are released to change the pH of the hydrogen peroxide solution, whereupon the enzyme catalyst is released at a pH of approx. 7th

Furthermore, suitable for the enzyme catalyst-containing neutralizing agent is a two-layered tablet, where one layer containing soluble salts serves to neutralize the hydrogen peroxide solution, while the other layer contains the enzyme catalyst, it being possible to release either the auxiliary materials or the enzyme catalyst first.

The neutralizing agent may also be present as a basic gel in a coating which is soluble at a pH of 7. The enzyme catalyst may also be present as a viscous solution of a coating surrounding the auxiliary materials.

Furthermore, the neutralizing agent may have a semi-permeable membrane as a coating through which the water which is to dissolve the excipients enters the interior and from which the dissolved salts reach the outside due to the osmotic pressure. For this purpose, the semipermeable membrane may have a perforation, or it may be destroyed by the osmotic pressure, thereby releasing the auxiliary materials and enzyme catalyst. The enzyme catalyst may be present as a shrouded enzyme product.

In addition, a two-layer system with a soluble and a semi-permeable membrane is suitable for delayed release of the auxiliary materials and enzyme catalyst. An insoluble membrane system can be replaced by reuse.

An appropriate two-layer system can be constructed in such a way that the enzyme catalyst is surrounded by the semipermeable membrane on whose outer auxiliary materials are located. Furthermore, a coating which is soluble at the pH (less than 4) in the stable hydrogen peroxide solution surrounds the auxiliary materials and the semipermeable membrane enclosing the enzyme catalyst.

The decomposition of the hydrogen peroxide can be detected by a color indicator. In this connection, it is a matter of adding a pH / redox indicator which does not penetrate into the soft hydrophilic contact lenses and is physiologically safe. The color indicator may also be arranged such that it has a color at a pH of 7 in the presence of hydrogen peroxide and is colorless at a pH of 7 in the absence of hydrogen peroxide.

20

The container in which the contact lens treatment is performed may have ventilation means in the form of e.g. a Bunsen valve through which the oxygen released during the neutralization and decomposition of the hydrogen peroxide can be avoided.

25

The invention will be explained in more detail below with reference to the drawing, in which 1-5 show various examples of systems containing hydrogen peroxide and decomposition enzyme catalyst; Figure 6 shows the time course of processing a contact lens with an example of the use of the contact lens cleaning kit; 7 is a side view of a treatment container; and FIG. Figure 8 shows a plan view of a container portion that can be screwed into the treatment container and containing particulate carriers to which a hydrogen peroxide decomposing enzyme catalyst is attached.

In the embodiment of FIG. 1, auxiliary materials 1 and a hydrogen peroxide cleaving enzyme catalyst 2, e.g. in the form 5 of catalase, randomly distributed in an outer casing or coating 3. This outer coating 3 may be water-soluble or semi-permeable after being subjected to action for a certain period of time by the hydrogen peroxide having a sterilizing effect on the contact lenses. to be treated. The thickness of the coating regulates the period of up to 4 hours during which the hydrogen peroxide acts on the lenses, before a sufficient amount of catalase and auxiliary materials are released by dissolving the coating 3 or by virtue of the semi-permeability of this coating to neutralize and eliminate the sterilizing hydrogen peroxide. by enzyme catalytic decomposition. In this example, the auxiliary materials and enzyme catalyst can be released at the same time.

In the embodiment of FIG. 2, the auxiliary materials 1 20 are first released, thereby neutralizing the sterilizing hydrogen peroxide solution. Then the hydrogen peroxide-destroying enzyme catalyst 2, e.g. in the form of catalase, works. For this purpose, there is provided an outer casing or coating 3 which, after the action of the hydrogen peroxide, is soluble or sufficiently semipermeable and surrounds the auxiliary materials 1. The auxiliary materials 1 surround the enzyme catalyst 2, which is again surrounded by a inner sleeve or coating 4 which may also be soluble or semi-permeable.

30 In the embodiment of FIG. 3, the enzyme catalyst 2 and the auxiliary materials 1 are adjacent to each other and are surrounded by a common outer casing or coating which is water-soluble or semi-permeable. In this case, the auxiliary materials 35 1 and the enzyme catalyst 2 can be separated by a separate living egg 5.

14 DK 166654 B1 shown in FIG. 4, the enzyme catalyst 2, which may be present in the form of a viscous solution, is first released, after which the auxiliary materials 1 are released. In this embodiment, the enzyme catalyst 2 is surrounded by an outer casing or coating 3, and the auxiliary materials 1 are surrounded by an inner casing or coating 4. In this embodiment, the auxiliary materials 1 are innermost and surrounded by the enzyme catalyst 2.

10 In the embodiment of FIG. 5, the enzyme catalyst 2 is in the form of small catalyst grains or prills, and the auxiliary materials 1 are randomly distributed in the outer casing or coating 3 which may be soluble or semi-permeable.

FIG. 6 is a graphical representation of the time course of the treatment of the contact lenses with hydrogen peroxide and the subsequent destruction of the hydrogen peroxide when it has worked for a desired period of time. For example, the period of time during which the hydrogen peroxide works is determined by the thickness of the coating or by appropriate selection of the coating material. The hydrogen peroxide content is shown as ordinate, and it is seen that the initial concentration of hydrogen peroxide remains practically constant until the end of the period of action t ^. Upon release of the adjuvants and / or the enzyme catalyst, the hydrogen peroxide content of the treatment vessel drops rapidly.

FIG. 7 and 8 show schematically an example of the use of a treatment container 1 in which a recess 4 in a bottom part 2 has particulate carriers 3 on which a hydrogen peroxide degrading enzyme catalyst is immobilized. The bottom part 2 can e.g. be secured by a thread to the treatment container part 2 e.g. as described in German Publication No. 3,410,400. The carriers 35 3 coated with the enzyme catalyst are separated from the inner 7 of the container by an inert tissue 6 which is impermeable to the treatment solution contained within the inner 7 of the container. The color of the lid 8, which is also screwed on, to which the containers 9 of the contact lenses to be treated are attached, as shown in German 5 Publication No. 3,410,400, may have a different color from the color of the screwed-on bottom part 2, so that confusion is avoided.

Claims (41)

1. Contact lens cleaning kit with two treating agents, one of which is a sterilizing hydrogen peroxide and the other 5 is an enzyme catalyst-containing neutralizing agent for neutralizing and decomposing the hydrogen peroxide after sterilizing a contact lens, characterized in that the neutralizing agent and / or the enzyme catalyst is the combined with a delay agent which regulates the delayed release. Contact lens cleaning kit according to claim 1, characterized in that the enzyme catalyst-containing neutralizing agent is enclosed by a coating which, in contact with the hydrogen peroxide solution, releases the enzyme catalyst-containing neutralizing agent after the effect of the hydrogen peroxide solution for a specified period of time on the contact lens to be treated. Contact lens cleaning kit according to claim 1 or 2, characterized in that the neutralizing agent, in addition to the enzyme catalyst for decomposition of the hydrogen peroxide, contains auxiliary materials which neutralize the acidic hydrogen and peroxide solution. 25 Contact lens cleaning kit according to one of claims 1-3, characterized in that the enzyme catalyst for decomposition of the hydrogen peroxide is released before or after the auxiliary materials for the neutralization of the hydrogen peroxide solution. 30 Contact lens cleaning kit according to one of claims 1-4, characterized in that the delay agent is present as a water-soluble coating for the enzyme catalyst-containing neutralizing agent and consists of a polymer which is water-soluble in acidic or neutral medium. DK 166654 B1 Contact lens cleaning kit according to claim 5, characterized in that the polymer, which is soluble in acidic medium, is a polymer of dimethylaminomethacrylate and neutral methacrylic acid esters. 5 Contact lens cleaning kit according to claim 5, characterized in that the polymer, which is soluble in neutral medium, is a compound selected from soluble cellulose ethers, cellulose acetate phthalate, hydroxypropylmethylcellulose phthalate, a polymer of methacrylic acid and methacrylic acid acetate, a copolymer and a copolymer copolymer of methyl vinyl ether and maleic anhydride, and polyvinyl yl alcohols. Contact lens cleaning kit according to claim 7, characterized in that the soluble cellulose ethers are methyl cellulose, methyl hydroxypropyl cellulose, methyl hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose and sodium carboxymethyl cellulose. 20 Contact lens cleaning kit according to one of claims 5-8, characterized in that polyalcohols are added to the water-soluble polymer for controlling the delay time. Contact lens cleaning kit according to claim 9, characterized in that the polyalcohols are 1,2-propylene glycol, polyethylene glycol and citric acid. Contact lens cleaning kit according to one of claims 1-10, 30, characterized in that the coating takes the form of a water-soluble film. Contact lens cleaning kit according to claim 5 or 11, characterized in that the coating consists of polyvinyl alcohol. DK 166654 B1 Contact lens cleaning kit according to claim 11 or 12, characterized in that the polyvinyl alcohol film contains plasticizers of polyhydric alcohols and water in an amount of 3.5-5%. 5 Contact lens cleaning kit according to claim 1, characterized in that the delay agent is in the form of a semi-permeable membrane which encloses the enzyme catalyst-containing neutralizing agent and consists of ethyl cellulose or a copolymer of acrylic methacrylic acid esters with trimethyl ammonium methacrylic acid and methacrylic acid methyl acrylic acid or a mixture of 15. Contact lens cleaning kit according to claim 14, characterized in that plasticizers have been added to control the diffusion rate of the membrane. Contact lens cleaning kit according to claim 15, characterized in that the plasticizers are 1,2-propylene glycol, polyethylene glycols or citric acid esters. Contact lens cleaning kit according to one of claims 1-5, characterized in that the coating is water-soluble or semi-permeable at a pH (less than 4) at which the hydrogen peroxide solution is stable. Contact lens cleaning kit according to one of claims 1-4, characterized in that the coating has one or more perforations through which the auxiliary materials are released from the coating upon contact with the hydrogen peroxide solution, and that the coating is semi-permeable or soluble at a pH of approx. 7th Contact lens cleaning kit according to one of claims 1-4, characterized in that the enzyme catalyst is in the form of enzyme catalyst granules (catalyst prills) present in the coating together with the auxiliary materials. Contact lens cleaning kit according to claim 1, characterized in that the delay agent is in the form of a 5 heavy to insoluble matrix in which the enzyme catalyst-containing neutralizing agent is distributed. Contact lens cleaning kit according to claim 20, characterized in that the matrix consists of a compound selected from 10 cellulose ethers, alkali metal salts of alginic acid, methacrylic acid derivatives, acrylic acid derivatives, dextrans (molecular weight 1000-75000) and polyvinyl alcohol. The contact lens cleaning kit according to claim 20 or 21, characterized in that the matrix is of tablet form. Contact lens cleaning kit according to claim 1, characterized in that the delay agent is in the form of a film molded from a highly concentrated polymer solution in which the enzyme catalyst-containing neutralizing agent is embedded. Contact lens cleaning kit according to claim 23, characterized in that the foil material consists of alkali metal alginates, dextrans (molecular weight 1000-75000) and polyvinyl alcohol. Contact lens cleaning kit according to one of claims 1 to 4, characterized in that the enzyme catalyst-containing neutralizing agent consists of coated tablets, so that, in a delayed solution of the coating, release of the auxiliary materials first changes to the pH in the hydrogen peroxide solution and the catalyst at a pH of approx. 7th Contact lens cleaning kit according to one of claims 1 to 4, characterized in that the enzyme catalyst-containing neutralizing agent consists of a coated tablet and that a delayed solution of the coating first releases the enzyme catalyst and then of ælpematerialer-ne. 5 Contact lens cleaning kit according to claim 25 or 26, characterized in that the neutralizing agent is in the form of two-layer tablets, one layer consisting of soluble salts for neutralizing the hydrogen peroxide solution and the other layer being the enzyme catalyst. Contact lens cleaning kit according to one of claims 1-4, characterized in that the neutralizing agent is present as a basic gel in the coating which is soluble at a pH <7. Contact lens cleaning kit according to one of claims 1-4, characterized in that the enzyme catalyst is present as a viscous solution which surrounds the auxiliary materials in the coating. Contact lens cleaning kit according to one of claims 1-4, characterized in that the neutralizing agent is surrounded by a semipermeable membrane which is permeated by water to dissolve the auxiliary materials in the interior and from which the dissolved salts enter as a result of the osmotic pressure. Contact lens cleaning kit according to claim 30, characterized in that the semi-permeable membrane has one or more perforations. Contact lens cleaning kit according to claim 31, characterized in that the semipermeable membrane can be degraded by the osmotic pressure. 35 Contact lens cleaning kit according to claim 17 and one of claims DK 166654 B1 30-32, characterized in that the enzyme catalyst is surrounded by the semipermeable membrane on which the auxiliary materials lie, and that at the pH (<4) in the stable hydrogen peroxide solution water-soluble or semi-permeable coatings surround the auxiliary materials and the semipermeable membrane enclosing the enzyme catalyst. Contact lens cleaning kit according to claim 17 and one of claims 30-32, characterized in that the enzyme catalyst 10 is located on the outside of the membrane surrounding the auxiliary materials and that the water-soluble or semipermeable coating surrounds the enzyme catalyst and the membrane which encloses the auxiliary materials. Contact lens cleaning kit according to claim 1, characterized in that the delay agent is in the form of particulate support bodies to which the hydrogen peroxide decomposing enzyme catalyst is immobilized. The contact lens cleaning kit of claim 1, characterized in that the enzyme catalyst is catalase. 37. Contact lens cleaning kit according to claims 35 and 36, characterized in that the support members consist of acrylic resin and that the enzyme catalyst (catalase, peroxidase) is bonded over reactive oxirane groups on the support body. The contact lens cleaning kit according to claim 35 or 37, characterized in that the support bodies are disposed in a container portion which is detachable from the treatment container and is separated from the interior of the container containing the hydr and peroxide-containing treatment solution by a permeable inertifier. phloem. The contact lens cleaning kit according to claim 38, characterized in that the detachable container part is configured DK 166654 B1 as a removable container lid or container bottom. Contact lens cleaning kit according to one of claims 1-39, characterized in that the decomposition of the hydrogen peroxide is indicated by a color indicator. Contact lens cleaning kit according to claim 3, characterized in that the auxiliary materials are buffers based on NaH2PC> 4, Na2HPO4 and NaCl, film forming materials and wetting agents.