DK165686C - Fremgangsmaade til fremstilling af (3s)-3,4-trans-disubstituerede azetidinoner - Google Patents

Fremgangsmaade til fremstilling af (3s)-3,4-trans-disubstituerede azetidinoner

Info

Publication number
DK165686C
DK165686C DK169384A DK169384A DK165686C DK 165686 C DK165686 C DK 165686C DK 169384 A DK169384 A DK 169384A DK 169384 A DK169384 A DK 169384A DK 165686 C DK165686 C DK 165686C
Authority
DK
Denmark
Prior art keywords
trans
preparing
azetidinones
disubstituted
disubstituted azetidinones
Prior art date
Application number
DK169384A
Other languages
English (en)
Other versions
DK169384D0 (da
DK169384A (da
DK165686B (da
Inventor
Ivan Ernest
Jaroslav Kalvoda
Wolfgang Froestl
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK169384D0 publication Critical patent/DK169384D0/da
Publication of DK169384A publication Critical patent/DK169384A/da
Publication of DK165686B publication Critical patent/DK165686B/da
Application granted granted Critical
Publication of DK165686C publication Critical patent/DK165686C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK169384A 1983-03-28 1984-03-27 Fremgangsmaade til fremstilling af (3s)-3,4-trans-disubstituerede azetidinoner DK165686C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH167883 1983-03-28
CH167883 1983-03-28

Publications (4)

Publication Number Publication Date
DK169384D0 DK169384D0 (da) 1984-03-27
DK169384A DK169384A (da) 1984-09-29
DK165686B DK165686B (da) 1993-01-04
DK165686C true DK165686C (da) 1993-05-24

Family

ID=4216038

Family Applications (1)

Application Number Title Priority Date Filing Date
DK169384A DK165686C (da) 1983-03-28 1984-03-27 Fremgangsmaade til fremstilling af (3s)-3,4-trans-disubstituerede azetidinoner

Country Status (6)

Country Link
US (1) US4614614A (da)
EP (1) EP0126709B1 (da)
JP (1) JPS59181254A (da)
DE (1) DE3484362D1 (da)
DK (1) DK165686C (da)
IE (1) IE57095B1 (da)

Families Citing this family (36)

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EP0003960B1 (de) * 1978-02-02 1983-06-29 Ciba-Geigy Ag 6-Substituierte Thia-Azaverbindungen, ihre Herstellung und diese enthaltende pharmazeutische Präparate
JPH0649710B2 (ja) * 1984-08-06 1994-06-29 藤沢薬品工業株式会社 アゼチジノン誘導体およびその製造法
DE3567644D1 (de) * 1984-10-18 1989-02-23 Hoffmann La Roche Sterical uniform 2-azetidinones
JPS61267553A (ja) * 1984-11-29 1986-11-27 Sankyo Co Ltd アゼチジノン誘導体およびその製法
US4882429A (en) * 1986-03-03 1989-11-21 Schering Corporation Stereospecific preparation of (3S,4R,5R)-3-(1-hydroxyethyl)-4-benzoyloxy-azeridinones from L-(-)-theonine
US4740595A (en) * 1986-03-13 1988-04-26 Schering Corporation Preparation of azetidinones via N-protected oxirancecarboxamide intermediates
US5008404A (en) * 1988-08-01 1991-04-16 Schering Corporation Preparation of azetidinones via novel protected intermediates
US4963670A (en) * 1986-03-13 1990-10-16 Schering Corporation Preparation of azetidinones via novel protected intermediates
US4827006A (en) * 1986-03-13 1989-05-02 Schering Corporation Preparation of azetidinones via novel protected intermediates
DE3615520A1 (de) * 1986-05-07 1987-11-12 Bayer Ag Verfahren zur herstellung von 2,3-epoxyamiden
FR2609032B1 (fr) * 1986-12-30 1990-01-05 Centre Nat Rech Scient Epoxydes fonctionnels enantiomeriquement purs, leur procede de preparation et leur application comme synthons chiraux
US5274188A (en) * 1987-05-04 1993-12-28 Ciba-Geigy Corporation Process for the manufacture of 4-acyloxy-3-hydroxyethyl-azetidinones
JPH0623150B2 (ja) * 1988-11-15 1994-03-30 高砂香料工業株式会社 光学活性３−ヒドロキシブタン酸類の製造方法
US4876365A (en) * 1988-12-05 1989-10-24 Schering Corporation Intermediate compounds for preparing penems and carbapenems
US5075439A (en) * 1990-08-17 1991-12-24 Pfizer Inc. Processes for (3S,4R)-3-[1(R)-t-butyl-dimethylsilyloxy)-ethyl]-4-[1-oxo-3-thiolanylthio(thiocarbonyl)thio]azetidin-2-ones and intermediates therefor
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
KR20080067717A (ko) * 2001-01-26 2008-07-21 쉐링 코포레이션 스테롤 흡수 억제제와 혈액 조절제를 포함하는 혈관 질환의치료 또는 예방용 약제학적 조성물
AR032643A1 (es) * 2001-01-26 2003-11-19 Schering Corp Combinaciones de inhibidor(es) de absorcion de esterol con agente(s) cardiovascular(es) para el tratamiento de condiciones vasculares
SK287746B6 (sk) * 2001-01-26 2011-08-04 Schering Corporation Použitie substituovaných azetidinónových zlúčenín na liečenie sitosterolémie
AR035739A1 (es) * 2001-01-26 2004-07-07 Schering Corp Composiciones farmaceuticas y combinaciones terapeuticas que comprenden secuestrante (s) de los acidos biliares y de inhibidor (es) de la absorcion de los esteroles y el uso de dichas composiciones para la manufactura de un medicamento para el tratamiento de indicaciones vasculares
AR033855A1 (es) * 2001-01-26 2004-01-07 Schering Corp Composiciones y combinaciones de activador(es) del receptor de activacion de proliferacion peroxis0mal (ppar) e inhibidor(es) de absorcion de esterol, el uso de dichas composiciones o combinaciones para la manufactura de un medicamento para el tratamiento para indicaciones vasculares, diabetes, obes
AR034204A1 (es) * 2001-01-26 2004-02-04 Schering Corp Composiciones y combinaciones de acido nicotinico y derivados del mismo con inhibidor(es) de la absorcion de los esteroles, y el uso de los mismos para preparar medicamentos para el tratamiento para indicaciones vasculares
PT1392287E (pt) * 2001-05-25 2007-02-28 Schering Corp Métodos para tratamento de doença de alzheimer e/ou regulação dos níveis de peptídeos β amilóide num sujeito
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
US20030119757A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods for treating or preventing vascular inflammation using sterol absorption inhibitor(s)
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
DK1429756T3 (da) * 2001-09-21 2007-03-19 Schering Corp Behandling af xanthoma med azetidinonderivater som sterolabsorptionsinhibitorer
WO2004043457A1 (en) * 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
ES2318274T3 (es) 2003-03-07 2009-05-01 Schering Corporation Compuestos de azetidinona sustituida, formulaciones y uso de los mismos para el tratamiento de hipercolesterolemia.
JP5137228B2 (ja) 2003-03-07 2013-02-06 メルク・シャープ・アンド・ドーム・コーポレーション 高コレステロール血症の処置のための置換アゼチジノン化合物、置換アゼチジノン処方物およびそれらの使用
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
MXPA05009502A (es) * 2003-03-07 2005-10-18 Schering Corp Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
DE10339168A1 (de) * 2003-08-21 2005-04-28 Kabelschlepp Gmbh Kettenlasche für eine Energieführungskette sowie Energieführungskette
US20050096307A1 (en) * 2003-11-05 2005-05-05 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55111463A (en) * 1979-02-21 1980-08-28 Sankyo Co Ltd Beta-lactam compound and its preparation
DE3069597D1 (en) * 1979-08-01 1984-12-13 Ciba Geigy Ag 3-substituted bicyclic azetidinone derivatives, process for their preparation, and intermediates as well as their preparation
JPS56142259A (en) * 1980-03-11 1981-11-06 Sankyo Co Ltd Beta-lactam compound and its preparation
DE3176517D1 (en) * 1980-04-24 1987-12-17 Beecham Group Plc Beta-lactam compounds, their preparation and use
ATA396081A (de) * 1980-09-15 1983-10-15 Richter Gedeon Vegyeszet Verfahren zur herstellung von eine c-acetylgruppe enthaltenden neuen heterocyclischen verbindungen
JPS57163362A (en) * 1981-03-30 1982-10-07 Sankyo Co Ltd Azetidinone derivative and its preparation

Also Published As

Publication number Publication date
JPH0557979B2 (da) 1993-08-25
DK169384D0 (da) 1984-03-27
DK169384A (da) 1984-09-29
EP0126709A1 (de) 1984-11-28
EP0126709B1 (de) 1991-04-03
DK165686B (da) 1993-01-04
IE840744L (en) 1984-09-28
JPS59181254A (ja) 1984-10-15
US4614614A (en) 1986-09-30
DE3484362D1 (de) 1991-05-08
IE57095B1 (en) 1992-04-22

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment
B1 Patent granted (law 1993)
PBP Patent lapsed