DK1654370T3 - Accelereret ebola-vaccination - Google Patents
Accelereret ebola-vaccination Download PDFInfo
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- DK1654370T3 DK1654370T3 DK04779743.6T DK04779743T DK1654370T3 DK 1654370 T3 DK1654370 T3 DK 1654370T3 DK 04779743 T DK04779743 T DK 04779743T DK 1654370 T3 DK1654370 T3 DK 1654370T3
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Claims (8)
1. Blanding afen adenoviral vektorpartikel omfattende et glycoprotein (GP) fra Ebola-virus og en adenoviral vektorpartikel omfattende et nukleoprotein (NP) fra Ebola-virus til anvendelse i accelereret vaccination afen vært, hvor intramuskulær administration af en enkelt dosis af blandingen giver beskyttelse indenfor fire uger, hvor blandingen har 1012 af hver af de adenovirale vektorpartikler.
2. Anvendelse afen blanding afen adenoviral vektorpartikel omfattende et glycoprotein (GP) fra Ebola-virus og en adenoviral vektor part i kel omfattende et nukleoprotein (NP) fra Ebola-virus til fremstillingen afen farmaceutisk sammensætning til accelereret vaccination afen vært, hvor intramuskulær administration af en enkelt dosis af blandingen giver beskyttelse indenfor fire uger, hvor blandingen har 1012 af hver af de adenovirale vektorpartikler.
3. Blandingen til anvendelse ifølge krav 1 eller til anvendelsen ifølge krav 2, hvor de adenovirale vektorpartikler er replikationsdefekte.
4. Blandingen til anvendelse ifølge krav 1 eller 3 eller til anvendelsen ifølge krav 2 eller 3, hvor adenovirusvektorpartiklerne er fra adenovirus type 5.
5. Blandingen til anvendelse ifølge et hvilket som helst af kravene 1, 3 og 4 eller til anvendelsen ifølge et hvilket som helst af kravene 2 til 4, hvor GP'et og NP'et udtrykkes fra promoter valgt fra gruppen bestående af insulinpromoter, human cytomegalovirus (CMV) promoter og dens tidligere promoter, simianvirus SV40 promoter, Rous sarcom virus LTR promoter, kylling-cytoplasmisk β-actin promoter, og tetracyclin-inducerbar promoter.
6. Blandingen til anvendelse ifølge et hvilket som helst af kravene 1 og 3 til 5 eller til anvendelsen ifølge et hvilket som helst af kravene 3 til 5, hvor GP, eller NP er et fuld-længde antigent virusprotein eller en del af det antigene virusprotein der indeholder det dominerende antigen, neutraliserende antigen, eller epitop af den patogene virus.
7. Blandingen til anvendelse ifølge et hvilket som helst af kravene 1 og 3 til 6 eller til anvendelsen ifølge et hvilket som helst af kravene 3 til 6, hvor GP, eller NP indeholder en region konserveret mellem glycoproteiner af mindst to stammer af Ebola-virus.
8. Blandingen til anvendelse ifølge et hvilket som helst af kravene 1 og 3 til 7 eller til anvendelsen ifølge et hvilket som helst af kravene 3 til 7, hvor GP eller NP er et modificeret antigen der er muteret således at GP eller NP gøres ikke-funktionelt som en viral komponent med opretholder dets antigenicitet.
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| WO (1) | WO2005012538A2 (da) |
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| PE20130588A1 (es) * | 2007-02-02 | 2013-05-21 | Amgen Inc | Hepcidina, antagonistas de la hepcidina y metodos de uso |
| JP5636284B2 (ja) * | 2007-12-18 | 2014-12-03 | トラスティーズ オブ ボストン ユニバーシティ | フィロウイルスまたはアレナウイルス感染の暴露前または暴露後の治療法 |
| WO2009116983A2 (en) * | 2007-12-18 | 2009-09-24 | Trustees Of Boston University | Compositions and methods for treating ebola virus infection |
| AU2011230619C1 (en) | 2010-03-25 | 2016-06-23 | Oregon Health & Science University | CMV glycoproteins and recombinant vectors |
| TR201902214T4 (tr) | 2010-04-16 | 2019-03-21 | Glaxosmithkline Biologicals Sa | Şempanze adenoviral vektörü-bazlı filovirüs aşıları. |
| AU2011343798B2 (en) * | 2010-12-14 | 2016-07-14 | Janssen Vaccines & Prevention B.V. | Adenovirus serotype 26 and serotype 35 filovirus vaccines |
| CA2941116A1 (en) * | 2014-02-28 | 2015-09-03 | Janssen Vaccines & Prevention B.V. | Replicating recombinant adenovirus vectors, compositions, and methods of use thereof |
| RU2578159C1 (ru) * | 2015-02-13 | 2016-03-20 | федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации" (ФГБУ "ФНИЦЭМ им. Н.Ф.Гамалеи" Минздрава России) | Иммунобиологическое средство и способ его использования для индукции специфического иммунитета против вируса эбола |
| RU2578160C1 (ru) * | 2015-03-31 | 2016-03-20 | федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации" (ФГБУ "ФНИЦЭМ им.Н.Ф.Гамалеи" Минздрава России) | Иммунобиологическое средство и способ его использования для индукции специфического иммунитета против вируса эбола (варианты) |
| MX2020006476A (es) * | 2017-12-21 | 2020-12-10 | Pasteur Institut | Vacuna contra el virus de lassa. |
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| EP0669987B1 (en) * | 1992-09-25 | 2008-08-13 | Aventis Pharma S.A. | Adenovirus vectors for the transfer of foreign genes into cells of the central nervous system, particularly in brain |
| US20040009936A1 (en) * | 1999-05-03 | 2004-01-15 | Tang De-Chu C. | Vaccine and drug delivery by topical application of vectors and vector extracts |
| US6544780B1 (en) * | 2000-06-02 | 2003-04-08 | Genphar, Inc. | Adenovirus vector with multiple expression cassettes |
| US20020155127A1 (en) * | 2000-06-02 | 2002-10-24 | Danher Wang | Genetic vaccine against human immunodeficiency virus |
| EP1504112A4 (en) * | 2001-10-01 | 2006-02-08 | Us Health | DEVELOPMENT OF A VACCINE FOR THE PREVENTION OF INFECTIONS WITH THE FILOVIRUS IN PRIMATES |
| AU2003232004A1 (en) * | 2002-04-30 | 2003-11-17 | The Trustees Of The University Of Pennsylvania | Chimeric ebola virus envelopes and uses therefor |
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| US20060269572A1 (en) | 2006-11-30 |
| US8017130B2 (en) | 2011-09-13 |
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| EP1654370B1 (en) | 2018-05-30 |
| CA2534351A1 (en) | 2005-02-10 |
| AU2004262022B2 (en) | 2010-10-28 |
| WO2005012538A3 (en) | 2006-01-26 |
| AU2011200335B2 (en) | 2013-02-07 |
| WO2005012538A2 (en) | 2005-02-10 |
| US7635485B2 (en) | 2009-12-22 |
| AU2011200335A1 (en) | 2011-02-17 |
| US20100047282A1 (en) | 2010-02-25 |
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