DK1651612T5 - 3,4-Disubstituted 1H-pyrazole Compounds and Their Use as Cyclin Dependent Kinases (CDK) and Glycogen Synthase Kinase 3- (GSK) Modulators - Google Patents
3,4-Disubstituted 1H-pyrazole Compounds and Their Use as Cyclin Dependent Kinases (CDK) and Glycogen Synthase Kinase 3- (GSK) ModulatorsInfo
- Publication number
- DK1651612T5 DK1651612T5 DK04743512.8T DK04743512T DK1651612T5 DK 1651612 T5 DK1651612 T5 DK 1651612T5 DK 04743512 T DK04743512 T DK 04743512T DK 1651612 T5 DK1651612 T5 DK 1651612T5
- Authority
- DK
- Denmark
- Prior art keywords
- hydrogen
- alkoxy
- halogen
- optionally substituted
- carbocyclic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
The invention provides compounds of the formula (0) or salts or tautomers or N-oxides or solvates thereof for use in the prophylaxis or treatment of disease states and conditions such as cancers mediated by cyclin-dependent kinase and glycogen synthase kinase-3. In formula (0): X is a group R1-A-NR4-or a 5-or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C=O, NRg(C=O) or O(C=O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g. fluorine), hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy (e.g. methoxy); or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy); R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy (e.g. methoxy).
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48904603P | 2003-07-22 | 2003-07-22 | |
GBGB0317127.9A GB0317127D0 (en) | 2003-07-22 | 2003-07-22 | Pharmaceutical compounds |
US56976304P | 2004-05-10 | 2004-05-10 | |
PCT/GB2004/003179 WO2005012256A1 (en) | 2003-07-22 | 2004-07-22 | 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
DK1651612T3 DK1651612T3 (en) | 2012-07-23 |
DK1651612T5 true DK1651612T5 (en) | 2012-10-22 |
Family
ID=27772442
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10175329.1T DK2256106T3 (en) | 2003-07-22 | 2004-07-22 | 3,4-disubstituted 1H-pyrazole compounds and their use as cyclin-dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators |
DK04743512.8T DK1651612T5 (en) | 2003-07-22 | 2004-07-22 | 3,4-Disubstituted 1H-pyrazole Compounds and Their Use as Cyclin Dependent Kinases (CDK) and Glycogen Synthase Kinase 3- (GSK) Modulators |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10175329.1T DK2256106T3 (en) | 2003-07-22 | 2004-07-22 | 3,4-disubstituted 1H-pyrazole compounds and their use as cyclin-dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators |
Country Status (11)
Country | Link |
---|---|
CN (1) | CN1826323B (en) |
AT (1) | ATE553091T1 (en) |
DK (2) | DK2256106T3 (en) |
ES (2) | ES2539480T3 (en) |
GB (1) | GB0317127D0 (en) |
HU (1) | HUE025425T2 (en) |
PT (2) | PT1651612E (en) |
RU (1) | RU2408585C2 (en) |
SI (2) | SI2256106T1 (en) |
TW (1) | TWI356823B (en) |
ZA (1) | ZA200600313B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2947546B1 (en) * | 2009-07-03 | 2011-07-01 | Sanofi Aventis | PYRAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
KR101844615B1 (en) * | 2010-07-02 | 2018-05-14 | 아스카 세이야쿠 가부시키가이샤 | Heterocyclic compound, and p27 kip1 degradation inhibitor |
CN103012428A (en) * | 2013-01-08 | 2013-04-03 | 中国药科大学 | 4-(five-membered heterocycle pyrimidin/substituted pyridine) amino-1H-3-pyrazolecarboxamide CDK (cyclin dependent kinase)/Aurora dual inhibitor and application thereof |
CN104592251B (en) * | 2015-01-23 | 2019-10-01 | 上海复星医药产业发展有限公司 | 4- (condensed hetero ring substituted-amino) -1H- pyrazole-3-formamide class compound and application thereof |
US20180161340A1 (en) * | 2015-06-18 | 2018-06-14 | St. Jude Children's Research Hospital | Methods and compositions for the prevention and treatment of hearing loss |
CN107245073B (en) * | 2017-07-11 | 2020-04-17 | 中国药科大学 | 4- (aromatic heterocycle substituted) amino-1H-3-pyrazolecarboxamide FLT3 inhibitor and application thereof |
MA52360A (en) | 2018-04-26 | 2021-03-03 | Pfizer | 2-AMINO-PYRIDINE OR 2-AMINO-PYRIMIDINE DERIVATIVES USED AS CYCLINE-DEPENDENT KINASE INHIBITORS |
CN111848579B (en) * | 2019-04-26 | 2023-11-14 | 君实润佳(上海)医药科技有限公司 | Prodrugs of 4- (2, 6-dichlorobenzoylamino) -N- (4-piperidinyl) -1H-pyrazole-3-carboxamide |
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2003
- 2003-07-22 GB GBGB0317127.9A patent/GB0317127D0/en not_active Ceased
-
2004
- 2004-07-22 ES ES10175329.1T patent/ES2539480T3/en active Active
- 2004-07-22 SI SI200432244T patent/SI2256106T1/en unknown
- 2004-07-22 CN CN2004800211596A patent/CN1826323B/en not_active Expired - Fee Related
- 2004-07-22 PT PT04743512T patent/PT1651612E/en unknown
- 2004-07-22 HU HUE10175329A patent/HUE025425T2/en unknown
- 2004-07-22 TW TW093121972A patent/TWI356823B/en not_active IP Right Cessation
- 2004-07-22 AT AT04743512T patent/ATE553091T1/en active
- 2004-07-22 ES ES04743512T patent/ES2385328T3/en active Active
- 2004-07-22 DK DK10175329.1T patent/DK2256106T3/en active
- 2004-07-22 PT PT101753291T patent/PT2256106E/en unknown
- 2004-07-22 DK DK04743512.8T patent/DK1651612T5/en active
- 2004-07-22 SI SI200431891T patent/SI1651612T1/en unknown
- 2004-07-22 RU RU2006105338/04A patent/RU2408585C2/en not_active IP Right Cessation
-
2006
- 2006-01-12 ZA ZA200600313A patent/ZA200600313B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ES2385328T3 (en) | 2012-07-23 |
ZA200600313B (en) | 2007-02-28 |
CN1826323A (en) | 2006-08-30 |
PT2256106E (en) | 2015-07-22 |
RU2408585C2 (en) | 2011-01-10 |
DK1651612T3 (en) | 2012-07-23 |
ES2539480T3 (en) | 2015-07-01 |
SI1651612T1 (en) | 2012-09-28 |
PT1651612E (en) | 2012-07-06 |
HUE025425T2 (en) | 2016-02-29 |
ATE553091T1 (en) | 2012-04-15 |
RU2006105338A (en) | 2007-09-20 |
SI2256106T1 (en) | 2015-10-30 |
DK2256106T3 (en) | 2015-06-01 |
GB0317127D0 (en) | 2003-08-27 |
CN1826323B (en) | 2012-06-27 |
TW200524877A (en) | 2005-08-01 |
TWI356823B (en) | 2012-01-21 |
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