DK164051C - 2-(aminoalkylthio)methyl-1,4-dihydropyridin-forbindelser samt farmaceutisk middel indeholdende en saadan forbindelse - Google Patents

2-(aminoalkylthio)methyl-1,4-dihydropyridin-forbindelser samt farmaceutisk middel indeholdende en saadan forbindelse

Info

Publication number
DK164051C
DK164051C DK099588A DK99588A DK164051C DK 164051 C DK164051 C DK 164051C DK 099588 A DK099588 A DK 099588A DK 99588 A DK99588 A DK 99588A DK 164051 C DK164051 C DK 164051C
Authority
DK
Denmark
Prior art keywords
aminoalkylthio
methyl
compound
pharmaceutical composition
composition containing
Prior art date
Application number
DK099588A
Other languages
Danish (da)
English (en)
Other versions
DK99588A (da
DK164051B (da
DK99588D0 (da
Inventor
Carmelo A Gandolfi
Marco Frigerio
Silvano Spinelli
Odoardo Tofanetti
Sergio Tognella
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Publication of DK99588A publication Critical patent/DK99588A/da
Publication of DK99588D0 publication Critical patent/DK99588D0/da
Publication of DK164051B publication Critical patent/DK164051B/da
Application granted granted Critical
Publication of DK164051C publication Critical patent/DK164051C/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK099588A 1986-06-27 1988-02-25 2-(aminoalkylthio)methyl-1,4-dihydropyridin-forbindelser samt farmaceutisk middel indeholdende en saadan forbindelse DK164051C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT20965/86A IT1204421B (it) 1986-06-27 1986-06-27 2-(aminoalchiltio)metil-1,4-diidropiridine,un metodo per la loro preparazione e composizioni farmaceutiche che le contengono
IT2096586 1986-06-27
PCT/EP1987/000335 WO1988000187A1 (en) 1986-06-27 1987-06-25 2-(aminoalkylthio)methyl-1,4-dihydropyridine, a method for the preparation thereof and pharmaceutical compositions containing them
EP8700335 1987-06-25

Publications (4)

Publication Number Publication Date
DK99588A DK99588A (da) 1988-02-25
DK99588D0 DK99588D0 (da) 1988-02-25
DK164051B DK164051B (da) 1992-05-04
DK164051C true DK164051C (da) 1992-09-28

Family

ID=11174716

Family Applications (1)

Application Number Title Priority Date Filing Date
DK099588A DK164051C (da) 1986-06-27 1988-02-25 2-(aminoalkylthio)methyl-1,4-dihydropyridin-forbindelser samt farmaceutisk middel indeholdende en saadan forbindelse

Country Status (19)

Country Link
US (1) US5047414A (US07166745-20070123-C00100.png)
EP (2) EP0254064B1 (US07166745-20070123-C00100.png)
JP (1) JPH0832686B2 (US07166745-20070123-C00100.png)
KR (1) KR950002154B1 (US07166745-20070123-C00100.png)
AU (1) AU603595B2 (US07166745-20070123-C00100.png)
CA (1) CA1322753C (US07166745-20070123-C00100.png)
DK (1) DK164051C (US07166745-20070123-C00100.png)
ES (1) ES2037029T3 (US07166745-20070123-C00100.png)
FI (1) FI91149C (US07166745-20070123-C00100.png)
GR (1) GR3004954T3 (US07166745-20070123-C00100.png)
HU (1) HU201305B (US07166745-20070123-C00100.png)
IT (1) IT1204421B (US07166745-20070123-C00100.png)
MX (1) MX7134A (US07166745-20070123-C00100.png)
NZ (1) NZ220868A (US07166745-20070123-C00100.png)
PH (1) PH23208A (US07166745-20070123-C00100.png)
PL (1) PL156170B1 (US07166745-20070123-C00100.png)
RU (1) RU1816282C (US07166745-20070123-C00100.png)
WO (1) WO1988000187A1 (US07166745-20070123-C00100.png)
ZA (1) ZA874636B (US07166745-20070123-C00100.png)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213555B (it) * 1986-12-11 1989-12-20 Boehringer Biochemia Srl 2 metiltiometildiidropiridine, un processo per laloro preparazione e composizioni farmaceutiche che le contengono.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
IL68604A0 (en) * 1982-05-21 1983-09-30 Haessle Ab Processes for preparing therapeutically active dihydropyridines and intermediates for the processes
PH19166A (en) * 1982-09-04 1986-01-16 Pfizer Dihydropyridined,pharmaceutical compositions and method of use
US4572908A (en) * 1982-12-21 1986-02-25 Pfizer Inc. Dihydropyridines
GB8306666D0 (en) * 1983-03-10 1983-04-13 Pfizer Ltd Therapeutic agents
GR851819B (US07166745-20070123-C00100.png) * 1984-08-17 1985-11-26 Wyeth John & Brother Ltd
WO1987000836A1 (en) * 1985-08-06 1987-02-12 Boehringer Biochemia Robin S.P.A. Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines

Also Published As

Publication number Publication date
IT1204421B (it) 1989-03-01
MX7134A (es) 1993-10-01
HUT49572A (en) 1989-10-30
AU7696987A (en) 1988-01-29
DK99588A (da) 1988-02-25
FI91149C (fi) 1994-05-25
DK164051B (da) 1992-05-04
JPH01503065A (ja) 1989-10-19
JPH0832686B2 (ja) 1996-03-29
WO1988000187A1 (en) 1988-01-14
CA1322753C (en) 1993-10-05
EP0254064B1 (en) 1992-06-17
US5047414A (en) 1991-09-10
PH23208A (en) 1989-06-06
EP0254064A1 (en) 1988-01-27
KR880701228A (ko) 1988-07-26
GR3004954T3 (US07166745-20070123-C00100.png) 1993-04-28
AU603595B2 (en) 1990-11-22
KR950002154B1 (ko) 1995-03-14
FI91149B (fi) 1994-02-15
ZA874636B (en) 1988-03-30
PL156170B1 (pl) 1992-02-28
EP0312541A1 (en) 1989-04-26
IT8620965A0 (it) 1986-06-27
EP0312541B1 (en) 1992-08-26
PL266481A1 (en) 1988-09-01
HU201305B (en) 1990-10-28
DK99588D0 (da) 1988-02-25
FI885930A (fi) 1988-12-21
NZ220868A (en) 1989-10-27
RU1816282C (ru) 1993-05-15
ES2037029T3 (es) 1993-06-16

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