DK1625212T3 - Kunstigt immunorgan - Google Patents

Kunstigt immunorgan

Info

Publication number
DK1625212T3
DK1625212T3 DK04733792T DK04733792T DK1625212T3 DK 1625212 T3 DK1625212 T3 DK 1625212T3 DK 04733792 T DK04733792 T DK 04733792T DK 04733792 T DK04733792 T DK 04733792T DK 1625212 T3 DK1625212 T3 DK 1625212T3
Authority
DK
Denmark
Prior art keywords
cells
cell
immune organ
artificial immune
supply fluid
Prior art date
Application number
DK04733792T
Other languages
Danish (da)
English (en)
Inventor
Hikmat Bushnaq-Josting
Marco Riedel
Uwe Marx
Christoph Giese
Original Assignee
Probiogen Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Probiogen Ag filed Critical Probiogen Ag
Application granted granted Critical
Publication of DK1625212T3 publication Critical patent/DK1625212T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0635—B lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
DK04733792T 2003-05-19 2004-05-19 Kunstigt immunorgan DK1625212T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03011338A EP1479760A1 (de) 2003-05-19 2003-05-19 Künstliches Immunorgan
PCT/EP2004/005412 WO2004101773A1 (en) 2003-05-19 2004-05-19 Artificial immune organ

Publications (1)

Publication Number Publication Date
DK1625212T3 true DK1625212T3 (da) 2007-10-22

Family

ID=33040959

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04733792T DK1625212T3 (da) 2003-05-19 2004-05-19 Kunstigt immunorgan

Country Status (14)

Country Link
US (1) US20060194320A1 (ja)
EP (2) EP1479760A1 (ja)
JP (1) JP4712709B2 (ja)
AT (1) ATE371019T1 (ja)
AU (1) AU2004239014B2 (ja)
CA (1) CA2526451C (ja)
CY (1) CY1107018T1 (ja)
DE (1) DE602004008453T2 (ja)
DK (1) DK1625212T3 (ja)
ES (1) ES2290714T3 (ja)
PL (1) PL1625212T3 (ja)
PT (1) PT1625212E (ja)
SI (1) SI1625212T1 (ja)
WO (1) WO2004101773A1 (ja)

Families Citing this family (24)

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Publication number Priority date Publication date Assignee Title
WO2005014149A1 (ja) * 2003-08-07 2005-02-17 Asahi Kasei Kabushiki Kaisha 複合多孔膜とその製造方法
US7709256B2 (en) 2004-04-28 2010-05-04 Vaxdesign Corp. Disease model incorporation into an artificial immune system (AIS)
US7785806B2 (en) 2004-04-28 2010-08-31 Vaxdesign Corporation Method for determining the immunogenicity of an antigen
US7855074B2 (en) 2004-04-28 2010-12-21 Vaxdesign Corp. Artificial immune system: methods for making and use
US20070141552A1 (en) * 2004-04-28 2007-06-21 Warren William L Automatable artificial immune system (AIS)
US8071373B2 (en) 2004-04-28 2011-12-06 Sanofi Pasteur Vaxdesign Corp. Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS)
US8298824B2 (en) 2004-04-28 2012-10-30 Sanofi Pasteur Vaxdesign Corporation Methods of evaluating a test agent in a diseased cell model
US8030070B2 (en) 2004-04-28 2011-10-04 Sanofi Pasteur Vaxdesign Corp. Artificial lymphoid tissue equivalent
US7771999B2 (en) 2004-04-28 2010-08-10 Vaxdesign Corp. Disease model incorporation into an artificial immune system (AIS)
CA2564512C (en) * 2004-04-28 2014-03-18 Vaxdesign Corporation Artificial immune system: methods for making and use
US7785883B2 (en) 2004-04-28 2010-08-31 Vax Design Corp. Automatable artificial immune system (AIS)
WO2007075979A2 (en) 2005-12-21 2007-07-05 Vaxdesign Corporation In vitro germinal centers
CA2655344C (en) 2006-06-27 2016-09-13 Vaxdesign Corporation Models for vaccine assessment
US8647837B2 (en) 2007-07-16 2014-02-11 Sanofi Pasteur Vaxdesign Corp. Artificial tissue constructs comprising alveolar cells and methods for using the same
WO2010145895A1 (en) * 2009-05-14 2010-12-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Compositions containing antibodies for treating cd5+ hla-dr+ b or t cell related diseases
DE102011106914B4 (de) 2011-07-08 2015-08-27 Zellwerk Gmbh Mäander- Bioreaktor und Verfahren zu dynamischen Expansion, Differenzierung und Ernte von hämatopoetischen Zellen
ITNA20120018A1 (it) * 2012-04-20 2013-10-21 Sergio Caserta Cella per la realizzazione di un saggio di chemiotassi in 2d e 3d mediante osservazione in microscopia in vitro.
CN107109331A (zh) * 2014-10-16 2017-08-29 昆塔麦特利斯株式会社 使用胶凝剂跟踪单细胞的新型生物活性测试结构
US10167444B2 (en) 2015-07-15 2019-01-01 The Regents Of The University Of Michigan Bioreactor and method of forming complex three-dimensional tissue constructs
CN105861310B (zh) * 2016-04-22 2018-05-22 福州创方医药科技有限公司 一体式t细胞培养装置及其使用方法
SG11201900422TA (en) * 2016-07-18 2019-02-27 Harvard College Human lymphoid tissue-on-chip
BE1024733B1 (fr) * 2016-11-09 2018-06-14 Univercells Sa Matrice de croissance cellulaire
CN111269834B (zh) * 2020-02-19 2023-06-06 杭州济扶科技有限公司 一种基于细胞软球体的3d体素打印方法
IL311991A (en) 2022-05-23 2024-06-01 Pluri Biotech Ltd A system for growth and activation of immune system cells on a high scale and methods of use

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Also Published As

Publication number Publication date
EP1625212B1 (en) 2007-08-22
JP2007500511A (ja) 2007-01-18
ATE371019T1 (de) 2007-09-15
CY1107018T1 (el) 2012-09-26
WO2004101773A1 (en) 2004-11-25
DE602004008453T2 (de) 2008-05-15
JP4712709B2 (ja) 2011-06-29
CA2526451A1 (en) 2004-11-25
SI1625212T1 (sl) 2008-02-29
EP1625212A1 (en) 2006-02-15
PL1625212T3 (pl) 2008-02-29
AU2004239014B2 (en) 2010-01-21
AU2004239014A1 (en) 2004-11-25
DE602004008453D1 (de) 2007-10-04
PT1625212E (pt) 2007-11-30
US20060194320A1 (en) 2006-08-31
EP1479760A1 (de) 2004-11-24
ES2290714T3 (es) 2008-02-16
CA2526451C (en) 2014-02-18

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