DK162441C - Analogifremgangsmaade til fremstilling af oe1alfa(z),2beta,3beta,5alfaaa-aminocyklopentanolalkan- eller -alkensyrer eller estere eller solvater deraf - Google Patents
Analogifremgangsmaade til fremstilling af oe1alfa(z),2beta,3beta,5alfaaa-aminocyklopentanolalkan- eller -alkensyrer eller estere eller solvater derafInfo
- Publication number
- DK162441C DK162441C DK191882A DK191882A DK162441C DK 162441 C DK162441 C DK 162441C DK 191882 A DK191882 A DK 191882A DK 191882 A DK191882 A DK 191882A DK 162441 C DK162441 C DK 162441C
- Authority
- DK
- Denmark
- Prior art keywords
- sub
- solvates
- oe1alfa
- aminocyclopentanolalkan
- 5alfaaa
- Prior art date
Links
- 239000012453 solvate Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010006482 Bronchospasm Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 230000007885 bronchoconstriction Effects 0.000 abstract 1
- 125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001326 naphthylalkyl group Chemical group 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8113238 | 1981-04-29 | ||
| GB8113238 | 1981-04-29 | ||
| GB8120459 | 1981-07-02 | ||
| GB8120459 | 1981-07-02 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK191882A DK191882A (da) | 1982-10-30 |
| DK162441B DK162441B (da) | 1991-10-28 |
| DK162441C true DK162441C (da) | 1992-03-23 |
Family
ID=26279290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK191882A DK162441C (da) | 1981-04-29 | 1982-04-29 | Analogifremgangsmaade til fremstilling af oe1alfa(z),2beta,3beta,5alfaaa-aminocyklopentanolalkan- eller -alkensyrer eller estere eller solvater deraf |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4977163A (fr) |
| EP (1) | EP0069447B1 (fr) |
| AT (1) | ATE23155T1 (fr) |
| AU (1) | AU564950B2 (fr) |
| CA (1) | CA1191134A (fr) |
| DE (1) | DE3273978D1 (fr) |
| DK (1) | DK162441C (fr) |
| ES (4) | ES511813A0 (fr) |
| FI (1) | FI78478C (fr) |
| HK (1) | HK45689A (fr) |
| IE (1) | IE53169B1 (fr) |
| IL (1) | IL65656A (fr) |
| MY (1) | MY8500957A (fr) |
| NZ (1) | NZ200461A (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU576476B2 (en) * | 1982-09-16 | 1988-09-01 | Glaxo Group Limited | Piperidinylcyclopentanol heptenoic acid salt |
| GB8601985D0 (en) * | 1986-01-28 | 1986-03-05 | Glaxo Group Ltd | Chemical process |
| US5221695A (en) * | 1987-12-22 | 1993-06-22 | Glaxo Group Limited | Aqueous formulation containing a piperidinylcyclopentylheptenoic acid derivative and beta-cyclodextrin |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1553293A (en) * | 1976-02-23 | 1979-09-26 | Lepetit Spa | Azaprostaglandins |
| US4189606A (en) * | 1976-02-23 | 1980-02-19 | Gruppo Lepetit S.P.A. | 13-Azaprostaglandins |
| NL7905375A (nl) * | 1978-07-11 | 1980-01-15 | Glaxo Group Ltd | Prostanoiden, werkwijze voor het bereiden daarvan, en daarop gebaseerde farmaceutische preparaten. |
| GB2028805B (en) * | 1978-07-11 | 1982-11-03 | Glaxo Group Ltd | Prostanoid compounds |
| US4239778A (en) * | 1978-09-12 | 1980-12-16 | The University Of Illinois Foundation | Azaprostanoic acid analogs and their use as inhibitors of platelet aggregation |
| AU542949B2 (en) * | 1980-01-09 | 1985-03-28 | Glaxo Group Limited | Prostanoid compounds |
| US4438111A (en) * | 1980-01-09 | 1984-03-20 | Glaxo Group Limited | Prostanoid compounds and pharmaceutical formulations |
| ZA81114B (en) * | 1980-01-09 | 1982-01-27 | Glaxo Group Ltd | Prostanoid compounds and their preparation and pharmaceutical formalation |
| IL62734A (en) * | 1980-04-30 | 1985-10-31 | Glaxo Group Ltd | Aminocyclopentane alkenoic acids and esters,their preparation and pharmaceutical formulations |
| US4371530A (en) * | 1980-07-04 | 1983-02-01 | Glaxo Group Limited | Aminocyclopentanone amides and pharmaceutical formulation |
| DE3162659D1 (en) * | 1980-07-22 | 1984-04-19 | Ono Pharmaceutical Co | 9,11-methano-13-aza-11a-carbathrombanoic acid analogues and pharmaceutical use thereof |
| US4410521A (en) * | 1981-09-16 | 1983-10-18 | Glaxo Group Limited | Aminocyclopentane esters and pharmaceutical formulations |
-
1982
- 1982-04-27 CA CA000401724A patent/CA1191134A/fr not_active Expired
- 1982-04-29 ES ES511813A patent/ES511813A0/es active Granted
- 1982-04-29 IE IE1015/82A patent/IE53169B1/en not_active IP Right Cessation
- 1982-04-29 EP EP82302227A patent/EP0069447B1/fr not_active Expired
- 1982-04-29 IL IL65656A patent/IL65656A/xx not_active IP Right Cessation
- 1982-04-29 DK DK191882A patent/DK162441C/da not_active IP Right Cessation
- 1982-04-29 AT AT82302227T patent/ATE23155T1/de not_active IP Right Cessation
- 1982-04-29 NZ NZ200461A patent/NZ200461A/en unknown
- 1982-04-29 FI FI821504A patent/FI78478C/fi not_active IP Right Cessation
- 1982-04-29 AU AU83107/82A patent/AU564950B2/en not_active Ceased
- 1982-04-29 DE DE8282302227T patent/DE3273978D1/de not_active Expired
-
1983
- 1983-02-01 ES ES519454A patent/ES519454A0/es active Granted
- 1983-09-16 ES ES525669A patent/ES8507126A1/es not_active Expired
-
1984
- 1984-04-30 ES ES532049A patent/ES8608501A1/es not_active Expired
-
1985
- 1985-12-30 MY MY957/85A patent/MY8500957A/xx unknown
-
1988
- 1988-04-11 US US07/183,293 patent/US4977163A/en not_active Expired - Fee Related
-
1989
- 1989-06-07 HK HK456/89A patent/HK45689A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0069447A2 (fr) | 1983-01-12 |
| MY8500957A (en) | 1985-12-31 |
| ES8306732A1 (es) | 1983-06-01 |
| NZ200461A (en) | 1985-09-13 |
| ES532049A0 (es) | 1986-06-16 |
| FI821504A0 (fi) | 1982-04-29 |
| ES8608501A1 (es) | 1986-06-16 |
| ES525669A0 (es) | 1985-08-16 |
| FI78478C (fi) | 1989-08-10 |
| IE53169B1 (en) | 1988-08-03 |
| CA1191134A (fr) | 1985-07-30 |
| ES8403468A1 (es) | 1984-03-16 |
| ES8507126A1 (es) | 1985-08-16 |
| AU8310782A (en) | 1982-11-04 |
| IL65656A (en) | 1985-10-31 |
| FI821504L (fi) | 1982-10-30 |
| DE3273978D1 (en) | 1986-12-04 |
| ES511813A0 (es) | 1983-06-01 |
| EP0069447A3 (en) | 1983-03-16 |
| HK45689A (en) | 1989-06-16 |
| ATE23155T1 (de) | 1986-11-15 |
| IE821015L (en) | 1982-10-29 |
| ES519454A0 (es) | 1984-03-16 |
| AU564950B2 (en) | 1987-09-03 |
| US4977163A (en) | 1990-12-11 |
| DK191882A (da) | 1982-10-30 |
| DK162441B (da) | 1991-10-28 |
| FI78478B (fi) | 1989-04-28 |
| EP0069447B1 (fr) | 1986-10-29 |
| IL65656A0 (en) | 1982-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |