ATE23155T1 - Aminozyklopentanol saeure und ester, ein verfahren zu ihrer herstellung und ihre pharmazeutische zusammensetzung. - Google Patents

Aminozyklopentanol saeure und ester, ein verfahren zu ihrer herstellung und ihre pharmazeutische zusammensetzung.

Info

Publication number
ATE23155T1
ATE23155T1 AT82302227T AT82302227T ATE23155T1 AT E23155 T1 ATE23155 T1 AT E23155T1 AT 82302227 T AT82302227 T AT 82302227T AT 82302227 T AT82302227 T AT 82302227T AT E23155 T1 ATE23155 T1 AT E23155T1
Authority
AT
Austria
Prior art keywords
sub
aminocyclopentanol
ester
acid
production
Prior art date
Application number
AT82302227T
Other languages
English (en)
Inventor
Eric William Collington
Peter Hallett
Christopher John Wallis
Road Newmarket
Alan Wadsworth
Norman Frank Hayes
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE23155T1 publication Critical patent/ATE23155T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
AT82302227T 1981-04-29 1982-04-29 Aminozyklopentanol saeure und ester, ein verfahren zu ihrer herstellung und ihre pharmazeutische zusammensetzung. ATE23155T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8113238 1981-04-29
GB8120459 1981-07-02
EP82302227A EP0069447B1 (de) 1981-04-29 1982-04-29 Aminozyklopentanol Säure und Ester, ein Verfahren zu ihrer Herstellung und ihre pharmazeutische Zusammensetzung

Publications (1)

Publication Number Publication Date
ATE23155T1 true ATE23155T1 (de) 1986-11-15

Family

ID=26279290

Family Applications (1)

Application Number Title Priority Date Filing Date
AT82302227T ATE23155T1 (de) 1981-04-29 1982-04-29 Aminozyklopentanol saeure und ester, ein verfahren zu ihrer herstellung und ihre pharmazeutische zusammensetzung.

Country Status (14)

Country Link
US (1) US4977163A (de)
EP (1) EP0069447B1 (de)
AT (1) ATE23155T1 (de)
AU (1) AU564950B2 (de)
CA (1) CA1191134A (de)
DE (1) DE3273978D1 (de)
DK (1) DK162441C (de)
ES (4) ES8306732A1 (de)
FI (1) FI78478C (de)
HK (1) HK45689A (de)
IE (1) IE53169B1 (de)
IL (1) IL65656A (de)
MY (1) MY8500957A (de)
NZ (1) NZ200461A (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU576476B2 (en) * 1982-09-16 1988-09-01 Glaxo Group Limited Piperidinylcyclopentanol heptenoic acid salt
GB8601985D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Chemical process
US5221695A (en) * 1987-12-22 1993-06-22 Glaxo Group Limited Aqueous formulation containing a piperidinylcyclopentylheptenoic acid derivative and beta-cyclodextrin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1553293A (en) * 1976-02-23 1979-09-26 Lepetit Spa Azaprostaglandins
US4189606A (en) * 1976-02-23 1980-02-19 Gruppo Lepetit S.P.A. 13-Azaprostaglandins
GB2028805B (en) * 1978-07-11 1982-11-03 Glaxo Group Ltd Prostanoid compounds
IT1117403B (it) * 1978-07-11 1986-02-17 Glaxo Group Ltd Composti prostanoidi e procedimento per produrli
US4239778A (en) * 1978-09-12 1980-12-16 The University Of Illinois Foundation Azaprostanoic acid analogs and their use as inhibitors of platelet aggregation
US4438111A (en) * 1980-01-09 1984-03-20 Glaxo Group Limited Prostanoid compounds and pharmaceutical formulations
ZA81114B (en) * 1980-01-09 1982-01-27 Glaxo Group Ltd Prostanoid compounds and their preparation and pharmaceutical formalation
AU542949B2 (en) * 1980-01-09 1985-03-28 Glaxo Group Limited Prostanoid compounds
JPS5718671A (en) * 1980-04-30 1982-01-30 Glaxo Group Ltd Aminocyclopentane alkenoic acid and esters thereof,manufacture and drug composition
US4371530A (en) * 1980-07-04 1983-02-01 Glaxo Group Limited Aminocyclopentanone amides and pharmaceutical formulation
DE3162659D1 (en) * 1980-07-22 1984-04-19 Ono Pharmaceutical Co 9,11-methano-13-aza-11a-carbathrombanoic acid analogues and pharmaceutical use thereof
US4410521A (en) * 1981-09-16 1983-10-18 Glaxo Group Limited Aminocyclopentane esters and pharmaceutical formulations

Also Published As

Publication number Publication date
ES525669A0 (es) 1985-08-16
NZ200461A (en) 1985-09-13
ES511813A0 (es) 1983-06-01
DK162441C (da) 1992-03-23
EP0069447A2 (de) 1983-01-12
IL65656A0 (en) 1982-07-30
ES8403468A1 (es) 1984-03-16
ES519454A0 (es) 1984-03-16
AU564950B2 (en) 1987-09-03
CA1191134A (en) 1985-07-30
ES8608501A1 (es) 1986-06-16
EP0069447B1 (de) 1986-10-29
AU8310782A (en) 1982-11-04
FI821504A0 (fi) 1982-04-29
FI821504L (fi) 1982-10-30
MY8500957A (en) 1985-12-31
HK45689A (en) 1989-06-16
EP0069447A3 (en) 1983-03-16
IE821015L (en) 1982-10-29
FI78478C (fi) 1989-08-10
US4977163A (en) 1990-12-11
DK162441B (da) 1991-10-28
ES532049A0 (es) 1986-06-16
DK191882A (da) 1982-10-30
ES8507126A1 (es) 1985-08-16
IE53169B1 (en) 1988-08-03
ES8306732A1 (es) 1983-06-01
IL65656A (en) 1985-10-31
FI78478B (fi) 1989-04-28
DE3273978D1 (en) 1986-12-04

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee