DK161588B - BLISTER PACKAGING FOR DIVIDABLE TABLETS - Google Patents

BLISTER PACKAGING FOR DIVIDABLE TABLETS Download PDF

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Publication number
DK161588B
DK161588B DK588184A DK588184A DK161588B DK 161588 B DK161588 B DK 161588B DK 588184 A DK588184 A DK 588184A DK 588184 A DK588184 A DK 588184A DK 161588 B DK161588 B DK 161588B
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DK
Denmark
Prior art keywords
lid
tablets
recess
groove
strip
Prior art date
Application number
DK588184A
Other languages
Danish (da)
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DK588184A (en
DK161588C (en
DK588184D0 (en
Inventor
Dieter Perthes
Original Assignee
Hoechst Ag
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Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK588184D0 publication Critical patent/DK588184D0/en
Publication of DK588184A publication Critical patent/DK588184A/en
Publication of DK161588B publication Critical patent/DK161588B/en
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Publication of DK161588C publication Critical patent/DK161588C/en

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed

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  • Composite Materials (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
  • Basic Packing Technique (AREA)
  • Medicines Containing Plant Substances (AREA)
  • External Artificial Organs (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)

Abstract

1. A blister package for divisible tablets, in which the tablets lie individually in the depression of a film, which are covered by another film, it being possible to remove the tablets individually by pressing them through this sealing film, wherein the package has a single cover (7) with which an opened depression (2) can be sealed.

Description

DK 161588 BDK 161588 B

Til faste lægemidler er de såkaldte blisteremballager trængt igennem/ i hvilke emballager tabletterne eller kapslerne ligger enkeltvis i fordybninger i en folie, hvilke fordybninger er overdækket med yderligere 5 en folie, og hvorfra tabletterne eller kapslerne enkeltvis kan udtages ved at disse trykkes igennem afdækningsfolien.For solid drugs, the so-called blister packages are penetrated / in which the tablets or capsules are individually in recesses in a foil, which recesses are covered with an additional foil and from which the tablets or capsules can be removed individually by pushing them through the cover foil.

yderligere har delbare tabletter, ved hvilke man ved en kærv eller lignende kan formindske doseringen af 10 lægemiddel på velegnet vis, fundet genklang. Placeres sådanne delbare tabletter i en blisterpakning opstår der problemer i tilknytning til tabletresternes sikre opbevaring, når der kun er indtaget en deldosis. Tilbagelægningen af tabletresterne i fordybningen i emballagefolien er util-15 fredsstillende, eftersom medikamentet ikke er beskyttet mod at falde ud og mod tilsmudsning. Det er muligt at tilvejebringe en forsegling med en klæbestrimmel, men det er temmelig besværligt, idet den gennembrudte folie først må' bredes ud over fordybningen for så vidt muligt at forhindre 20 berøring med klæbemidlet. Por ældre eller for handicappede patienter er denne metode ikke praktiserbar.furthermore, divisible tablets by which, in a groove or the like, the dosage of 10 drugs can be suitably reduced has been found to resonate. Placing such divisible tablets in a blister pack causes problems related to the safe storage of the tablet residues when only one sub-dose has been taken. The deposition of the tablet residues in the recess in the packaging foil is unsatisfactory since the drug is not protected from falling out and from soiling. It is possible to provide a seal with an adhesive strip, but it is rather troublesome, since the pierced foil must first be widened beyond the recess to prevent contact with the adhesive as far as possible. For elderly or disabled patients, this method is not practicable.

Europæisk patentansøgning nr. 84.119 viser i fig. 17 en tabletpakning, hvor tabletterne er placerede i fordybninger i en folie, hvilke lukkes ved indpresning af et låg, 25 idet der til hver fordybning af folien er udformet et låg.European Patent Application No. 84,119 shows in FIG. 17 is a tablet pack, wherein the tablets are placed in recesses in a foil which is closed by pressing a lid, 25 for each recess of the foil a lid is formed.

1 DE patentansøgning nr. 486.408 er omtalt en lignende udformet pakning, idet der dog kun er tilvejebragt ét låg med flere låseelementer i et antal, som svarer til antallet af fordybninger.In DE Patent Application No. 486,408, a similar shaped package is disclosed, however, only one lid having multiple locking elements is provided in a number corresponding to the number of recesses.

30 Opfindelsen angår derimod en blisterpakning af den indledningsvist omhandlede art til delbare tabletter som er karakteristisk ved at være udformet med en åben fordybning, som kan lukkes gentagne gange med et låg. Foretrukne udførelsesformer af opfindelsen forklares i det følgende nærmere.The invention, on the other hand, relates to a blister pack of the kind initially provided for divisible tablets which is characterized by having an open recess which can be closed repeatedly with a lid. Preferred embodiments of the invention are explained in more detail below.

3535

OISLAND

DK 161588BDK 161588B

2 I en udførelsesform af opfindelsen er låget tilspidset konisk henholdsvis kileformet, således at det ved friktion og/eller deformering fastholdes sikkert over den fordybning, som skal lukkes. Alternativt eller yderligere kan 5 en eller begge af de flader, som bringes i indbyrdes berøring ved lukningen, ved at gøre dem ru henholdsvis udforme' degn med små knopper, bølgelinier eller lignende, tilvejebringe en forbedret lukning. Ved en særlig fordelagtig udførelses-form af opfindelsen er låg og fordybning indbyrdes forbun-10 det efter not- og federprincippet, hvorved der eksempelvis rundt omkring fordybningen er udformet en dobbelt-vulst, som tilvejebringer noten, med hvilken en enkelt vulst på låget er i indgreb som en feder. Disse forbindelseselementer, not- og feder, kan være tilvejebragt 15 som særskilte elementer på blisterstrimlen og låget og klæbet eller svejset dertil. Med særlig stor fordel kan de dog være udformet i selve strimmel- og lågmaterialet, eksempelvis ved prægning eller med særlig fordel ved dybtrækning.2 In one embodiment of the invention, the lid is tapered conical and wedge-shaped, respectively, so that it is securely retained by friction and / or deformation over the recess to be closed. Alternatively or further, one or both of the surfaces which are brought into contact with the closure by roughening them respectively by forming knobs with small buds, wavy lines or the like can provide an improved closure. In a particularly advantageous embodiment of the invention, the lid and recess are interconnected according to the groove and spring principle, whereby, for example, a double bead is formed around the recess providing the groove with which a single bead on the lid intervention as a federal. These connecting elements, groove and spring, may be provided as separate elements on the blister strip and the lid and the adhesive or welded thereto. However, with particularly great advantage, they can be formed in the strip and lid material itself, for example by embossing or with special advantage in deep drawing.

2020

Porbindelseselementerne mellem låg og fordybning kan med fordel udformes rundt om hele fordybningen, idet der herved tilvejebringes en luft- og vandtæt .Mikning. Aflukningselementerne mellem not og feder kan - som delene i en trykknap - udvendig være vuls.tagtig udformet 25 og indvendig være udformet med en modsvarende fordybning (rille). I en yderligere foretrukken udførelsesform af opfindelsen er låget fast forbundet med blisterstrimlen.Advantageously, the pore connection elements between the lid and the recess can be formed around the entire recess, thereby providing an air and waterproof mixing. The groove elements between groove and spring can - like the parts of a pushbutton - be externally shaped 25, and internally be formed with a corresponding recess (groove). In a further preferred embodiment of the invention, the lid is firmly connected to the blister strip.

Herved forhindres, at låget forsvinder. Forbindelsen mellem blisterstrimlen og låget kan være tilvejebragt gen-30 nem et eller flere bånd henholdsvis strimler, idet der eksempelvis er udstanset segmenter mellem blisterstrimlen og låget således, at en mere eller mindre bred strimmel (henholdsvis flere strimler) bliver tilbage som forbindelseselement. I en yderligere fordelagtig udførelses-35 „ form af opfindelsen, er låget forbundet med blisterstrim-This prevents the lid from disappearing. The connection between the blister strip and the lid can be provided by one or more strips or strips, for example, segments are cut between the blister strip and the lid so that a more or less wide strip (or several strips) remains as connecting element. In a further advantageous embodiment of the invention, the lid is connected to blister strips.

DK 161588 BDK 161588 B

3 len ved et hængselagtigt organ, f.eks. ved en fals, således, at låget ved én bevægelse af dette hængsel henholdsvis i falsen føres hen over den fordybning, som skal lukkes, og ved et tryk let kan fastholdes.3 by a hinged member, e.g. by means of a fold, so that the lid, in one movement of this hinge, respectively in the fold, is passed over the recess which is to be closed and can be easily held by a pressure.

5 I yderligere en foretrukken udførelsesform af op findelsen er låget udformet med en tunge, som gør åbningen lettere. Denne tunge kan også tjene til fastholdelse af dækslet, idet den f.eks. kan trækkes igennem en sløjfe eller kan fastgøres efter not- og feder- henholdsvis tryk-10 knapprincippet på strimlen.In a further preferred embodiment of the invention, the lid is formed with a tongue which facilitates opening. This tongue may also serve to hold the cover, e.g. can be drawn through a loop or can be fastened according to the groove and spring and press-button buttons on the strip, respectively.

Den fordybning, som skal aflukkes, kan indeholde en tablet. Dog kan der også være afsat en særlig fordybning som magasin for tabletrester. I så tilfælde fyldes altså f.eks. en strimmel med 11 fordybninger kun med 10 tablet-15 ter, idet der mest hensigtsmæssigt forbliver en fordybning fri i den ende af blisterstrimlen, hvor låget er tilvejebragt.The recess to be closed may contain a tablet. However, a special recess may also be set aside as a magazine for tablet residues. In that case, for example, fill. a strip of 11 recesses only of 10 tablets, the most convenient being a recess free at the end of the blister strip where the lid is provided.

I den udførelsesform af opfindelsen, hvor der er tilvejebragt en tunge på låget på den ene side og på den 20 anden side en særlig fordybning (som magasin for tabletresterne) , kan denne fordybning - eller med fordel kun dens lukkeorgan, dvs. fortrinsvis noten henholdsvis federen -også være således udformet, at den bort fra hængslet hhv. falsen vendende langside på noten hhv. federen ikke er udfor-25 met med afrundede kanter, men er mere eller mindre skarpkantet. Den såkaldte "skarpkantede" not hhv. feder er således den kant, som på låget ligger nærmest ved tungen. Denne udformning har den fordel, at det lukkede magasin hhv. dets lukkeorgan er nemmere at åbne - først og fremmest ved den 30 "skarpkantede" not hhv. feder - ved et træk i tungen, hvorved en rykvis oplukning kan undgås.In the embodiment of the invention, where a tongue is provided on the lid on one side and on the other side a special recess (as a magazine for the tablet residues), this recess - or preferably only its closure means, i.e. preferably the note or the spring -and also be designed so that it is removed from the hinge and, respectively. the fold facing long side of the note respectively. The spring is not shaped with rounded edges, but is more or less sharp-edged. The so-called "sharp-edged" groove, respectively. spring is thus the edge closest to the tongue. This design has the advantage that the closed magazine and the magazine respectively. its closing means are easier to open - first and foremost at the 30 "sharp-edged" groove and groove, respectively. spring - by a pull in the tongue, thus avoiding a jerky opening.

Særlig fordelagtige er de ved opfindelsen tilvejebragte blisteremballager til tabletter, som kan deles flere gange, især til de flere gange delbare aflange tab-35 letter. I en foretrukken udførelsesform af opfindelsen er fordybningerne i blisterstrimlen således udformet, at disse aflange tabletter kan stå på højkant.Particularly advantageous are the blister packages provided by the invention for tablets which can be divided several times, especially for the several divisible elongated tablets. In a preferred embodiment of the invention, the recesses in the blister strip are designed so that these elongated tablets can stand upright.

- DK 161588B- DK 161588B

44

OISLAND

Fig. 1 viser et endestykke af en blisterstrimmel set oppefra, idet blisterstrimlen l's yderste fordybning 2 fra begyndelsen ikke er lukket, mens de øvrige fordybninger 3 alle oprindelig var lukkede med afdækningsfolie 5 4, idet afdækningsfolien 4 dog er fjernet fra den sidste.FIG. 1 shows an end portion of a blister strip seen from above, the blister strip 1's outer recess 2 not initially closed, while the other recesses 3 were all initially closed with cover film 5 4, however, the cover film 4 was removed from the last one.

Omkring fordybningen 2, er der tilvejebragt en ringformet dobbeltvulst 5, og i den således tilvejebragte not, er vulsten 6 i indgreb, når låget 7 bevæges omkring falsen 8. Tungen 9 gør åbningen af det lukkede tabletmagasin nemmere.Around the recess 2, an annular double bead 5 is provided, and in the groove thus provided, the bead 6 engages as the lid 7 moves around the socket 8. The tongue 9 facilitates the opening of the closed tablet magazine.

10 Der er tilvejebragt en flere gange delelig tablet 10, udformet med kærv 11. En perforations!inie 12 gør den strimmelvise aftrækning af afdækningsfolien 4 nemmere, når en oprindelig med en tablet opfyldt fordybning skal virke som restmagasin. Det undgås således, at resterne af afdæknings- 15 folien vanskeliggør lukning af låget.10 A plurality of divisible tablet 10 formed with groove 11. A perforating strip 12 facilitates the stripping of the cover foil 4 when an indentation filled with a tablet is intended to act as a residual tray. It is thus avoided that the remains of the cover film make it difficult to close the lid.

Perforationslinien 12 kan også gå igennem begge folierne, dvs. grundfolien og afdækningsfolien 4 (ikke vist i figuren) og muliggør herved, at de emballerede tabletter - el.ler kapsler kan fjernes enkeltvis fra bl ister strimlen.The perforation line 12 may also pass through both sheets, i. the base foil and the cover foil 4 (not shown in the figure), thereby allowing the packaged tablets - or capsules to be removed individually from the blister strip.

20 Fig. 2 viser et tværsnit gennem blisteremballagen i fig. 1.FIG. 2 shows a cross section through the blister pack of FIG. First

25 30 \ / 3525 30 \ / 35

Claims (9)

1. Blisterpakning til delbare tabletter, hvor tabletterne enkeltvis er placerede i fordybninger i en folie, som er dækket med en anden folie, idet tabletterne kan udtages enkeltvis ved at trykke disse igennem afdækningsfolien, 5 kendetegnet ved at være tilvejebragt med et enkelt låg (7), hvormed en enkelt åbnet fordybning (2) kan lukkes.A blister pack for divisible tablets, wherein the tablets are individually placed in recesses in a foil covered with another foil, the tablets being withdrawn individually by pressing them through the cover foil, characterized by being provided with a single lid (7). ) by which a single open recess (2) can be closed. 2. Pakning ifølge krav 1, kendetegnet ved, at låget (7) lukkes ved en not- og federarbejdsmåde. 10Gasket according to claim 1, characterized in that the lid (7) is closed by a groove and spring method. 10 3, Pakning ifølge krav 2, kendetegnet ved, at en not (5) og en feder (6) er udformet af det samme materiale, som strimlen (1) og låget (7) er udformet af.Package according to claim 2, characterized in that a groove (5) and a spring (6) are formed of the same material of which the strip (1) and the lid (7) are formed. 4. Pakning ifølge krav 1-3, kendetegnet 15 ved, at låget (7) lukker rundt omkring fordybningen (2).Gasket according to claims 1-3, characterized in that the lid (7) closes around the recess (2). 5. Pakning ifølge krav 1-4, kendetegnet ved, at låget (7) er forbundet med blisterstrimlen (1).Packing according to claims 1-4, characterized in that the lid (7) is connected to the blister strip (1). 6. Pakning ifølge krav 5, kendetegnet ved, at forbindelsen ved et hængsel henholdsvis en fals 20 er bevasgelig.A gasket according to claim 5, characterized in that the connection is hinged at a hinge and a socket 20, respectively. 7. Pakning ifølge krav 1-6, kendetegnet ved, at låget (7) er udformet med en tunge (9).Gasket according to claims 1-6, characterized in that the lid (7) is formed with a tongue (9). 8. Pakning ifølge krav 5-7, kendet eg n"e t ved, at låget (7) er placeret ved blisterstrimlens (1) 25 ende, og kan gå i indgreb med den sidste nabofordybning (2).Packing according to claims 5-7, characterized in that the lid (7) is located at the end of the blister strip (1) and can engage the last adjacent recess (2). 9. Pakning ifølge krav 8, kendetegnet ved, at den bort fra falsen (8) vendende langside på den sidste fordybnings (2) lukningsorgan er skarpkantet. 30 35Gasket according to claim 8, characterized in that the long side facing away from the fold (8) on the closing member of the last recess (2) is sharp. 30 35
DK588184A 1983-12-08 1984-12-07 BLISTER PACKAGING FOR DIVIDABLE TABLETS DK161588C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3344393 1983-12-08
DE19833344393 DE3344393A1 (en) 1983-12-08 1983-12-08 BLISTER PACKS FOR DIVISIBLE TABLETS

Publications (4)

Publication Number Publication Date
DK588184D0 DK588184D0 (en) 1984-12-07
DK588184A DK588184A (en) 1985-06-09
DK161588B true DK161588B (en) 1991-07-22
DK161588C DK161588C (en) 1992-01-06

Family

ID=6216363

Family Applications (1)

Application Number Title Priority Date Filing Date
DK588184A DK161588C (en) 1983-12-08 1984-12-07 BLISTER PACKAGING FOR DIVIDABLE TABLETS

Country Status (19)

Country Link
EP (1) EP0146063B1 (en)
JP (1) JPS60158058A (en)
KR (1) KR850004238A (en)
AT (1) ATE40333T1 (en)
AU (1) AU575099B2 (en)
CA (1) CA1246501A (en)
DE (2) DE3344393A1 (en)
DK (1) DK161588C (en)
ES (1) ES293458Y (en)
FI (1) FI80655C (en)
GR (1) GR81201B (en)
HU (1) HU189951B (en)
IE (1) IE56216B1 (en)
IL (1) IL73758A (en)
MX (1) MX162000A (en)
NO (1) NO162505C (en)
NZ (1) NZ210453A (en)
PT (1) PT79624B (en)
ZA (1) ZA849538B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0148118B1 (en) * 1983-12-09 1990-03-07 Sandoz Ag Package
GB8821287D0 (en) * 1988-09-12 1988-10-12 Ici Plc Device
GB9525065D0 (en) 1995-12-07 1996-02-07 Smithkline Beecham Plc Packaging system
DE29804383U1 (en) 1998-03-12 1998-05-14 Klocke Verpackungs-Service GmbH, 76356 Weingarten Packaging, in particular for products in tablet form
FR2786469B1 (en) 1998-12-01 2001-02-16 Rhone Poulenc Rorer Sa "BLISTER" TYPE PACKAGING, PARTICULARLY FOR THE PACKAGING OF BREAKABLE PRODUCTS SUCH AS TABLETS
WO2015114749A1 (en) * 2014-01-29 2015-08-06 株式会社モリモト医薬 Oral medication-holding cell, strip packaging, and method for manufacturing oral medication-holding cells

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1099499A (en) * 1964-11-26 1968-01-17 Aspro Nicholas Ltd Improvements relating to the packaging of tablets
DE1486408A1 (en) * 1965-08-30 1969-04-17 Hoefliger & Karg Tear-open packaging
CH559127A5 (en) * 1972-12-22 1975-02-28 Artusi A B
DE2714877A1 (en) * 1977-04-02 1978-10-12 Uhlmann Maschf Josef PRESSURE PACK FOR SMALL PARTS, IN PARTICULAR TABLETS OR THE SAME
DE2917108A1 (en) * 1979-04-27 1980-11-06 Helmut Zanker Medicine package - with dosage trays for daily dose dispensing, closed by transparent flap
DE3201244A1 (en) * 1982-01-16 1983-07-28 pfm Plastik für die Medizin GmbH, 5000 Köln "MEDICINE DISPENSER"
EP0148118B1 (en) * 1983-12-09 1990-03-07 Sandoz Ag Package

Also Published As

Publication number Publication date
IL73758A (en) 1988-09-30
IE843144L (en) 1985-06-08
DK588184A (en) 1985-06-09
NO162505C (en) 1990-01-10
PT79624B (en) 1986-10-20
NZ210453A (en) 1988-07-28
FI844798L (en) 1985-06-09
NO162505B (en) 1989-10-02
JPS60158058A (en) 1985-08-19
ES293458U (en) 1986-08-01
ES293458Y (en) 1987-04-16
DK161588C (en) 1992-01-06
PT79624A (en) 1985-01-01
AU3642484A (en) 1985-06-13
DE3344393A1 (en) 1985-06-20
DE3476373D1 (en) 1989-03-02
ATE40333T1 (en) 1989-02-15
AU575099B2 (en) 1988-07-21
GR81201B (en) 1985-04-03
HUT37096A (en) 1985-11-28
FI844798A0 (en) 1984-12-05
EP0146063A2 (en) 1985-06-26
FI80655C (en) 1990-07-10
IE56216B1 (en) 1991-05-22
KR850004238A (en) 1985-07-11
IL73758A0 (en) 1985-03-31
FI80655B (en) 1990-03-30
EP0146063B1 (en) 1989-01-25
NO844912L (en) 1985-06-10
DK588184D0 (en) 1984-12-07
ZA849538B (en) 1985-07-31
HU189951B (en) 1986-08-28
EP0146063A3 (en) 1986-10-22
CA1246501A (en) 1988-12-13
MX162000A (en) 1991-03-19

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