DK1575354T3 - Melusin, et muskel-specifikt protein, som lægemiddelmål til forebyggelse og behandling af hjertesvigt, og anvendelser deraf - Google Patents
Melusin, et muskel-specifikt protein, som lægemiddelmål til forebyggelse og behandling af hjertesvigt, og anvendelser derafInfo
- Publication number
- DK1575354T3 DK1575354T3 DK02808278T DK02808278T DK1575354T3 DK 1575354 T3 DK1575354 T3 DK 1575354T3 DK 02808278 T DK02808278 T DK 02808278T DK 02808278 T DK02808278 T DK 02808278T DK 1575354 T3 DK1575354 T3 DK 1575354T3
- Authority
- DK
- Denmark
- Prior art keywords
- melusin
- heart failure
- muscle
- prevention
- treatment
- Prior art date
Links
- 206010019280 Heart failures Diseases 0.000 title abstract 2
- 102100033340 Integrin beta-1-binding protein 2 Human genes 0.000 title abstract 2
- 101710117514 Integrin beta-1-binding protein 2 Proteins 0.000 title abstract 2
- 239000003596 drug target Substances 0.000 title 1
- 210000003205 muscle Anatomy 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 230000007170 pathology Effects 0.000 abstract 3
- 230000009261 transgenic effect Effects 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 2
- 208000031229 Cardiomyopathies Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0375—Animal model for cardiovascular diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Environmental Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IT2002/000807 WO2004056176A1 (en) | 2002-12-19 | 2002-12-19 | Melusin, a muscle specific protein, as a drug target for prevention and treatment of heart failure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1575354T3 true DK1575354T3 (da) | 2009-01-26 |
Family
ID=32676766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02808278T DK1575354T3 (da) | 2002-12-19 | 2002-12-19 | Melusin, et muskel-specifikt protein, som lægemiddelmål til forebyggelse og behandling af hjertesvigt, og anvendelser deraf |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7531714B2 (da) |
| EP (1) | EP1575354B1 (da) |
| AT (1) | ATE415814T1 (da) |
| AU (1) | AU2002368482A1 (da) |
| CA (1) | CA2505374A1 (da) |
| DE (1) | DE60230196D1 (da) |
| DK (1) | DK1575354T3 (da) |
| ES (1) | ES2316655T3 (da) |
| IL (1) | IL168859A (da) |
| WO (1) | WO2004056176A1 (da) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1404941B1 (it) | 2010-05-12 | 2013-12-09 | Target Heart Biotec S R L | Proteina di fusione di melusina ricombinante quale agente farmacologico nel trattamento di patologie cardiache e relative composizioni |
-
2002
- 2002-12-19 EP EP02808278A patent/EP1575354B1/en not_active Expired - Lifetime
- 2002-12-19 ES ES02808278T patent/ES2316655T3/es not_active Expired - Lifetime
- 2002-12-19 DK DK02808278T patent/DK1575354T3/da active
- 2002-12-19 AT AT02808278T patent/ATE415814T1/de active
- 2002-12-19 AU AU2002368482A patent/AU2002368482A1/en not_active Abandoned
- 2002-12-19 US US10/538,736 patent/US7531714B2/en not_active Expired - Fee Related
- 2002-12-19 CA CA002505374A patent/CA2505374A1/en not_active Abandoned
- 2002-12-19 WO PCT/IT2002/000807 patent/WO2004056176A1/en not_active Application Discontinuation
- 2002-12-19 DE DE60230196T patent/DE60230196D1/de not_active Expired - Lifetime
-
2005
- 2005-05-30 IL IL168859A patent/IL168859A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1575354A1 (en) | 2005-09-21 |
| EP1575354B1 (en) | 2008-12-03 |
| US20060059577A1 (en) | 2006-03-16 |
| CA2505374A1 (en) | 2004-07-08 |
| ES2316655T3 (es) | 2009-04-16 |
| AU2002368482A1 (en) | 2004-07-14 |
| DE60230196D1 (de) | 2009-01-15 |
| ATE415814T1 (de) | 2008-12-15 |
| IL168859A (en) | 2011-10-31 |
| US7531714B2 (en) | 2009-05-12 |
| WO2004056176A1 (en) | 2004-07-08 |
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