DK1559779T3 - Modificerede inosin-monophosphatdehydrogenaser - Google Patents

Modificerede inosin-monophosphatdehydrogenaser

Info

Publication number
DK1559779T3
DK1559779T3 DK05001460T DK05001460T DK1559779T3 DK 1559779 T3 DK1559779 T3 DK 1559779T3 DK 05001460 T DK05001460 T DK 05001460T DK 05001460 T DK05001460 T DK 05001460T DK 1559779 T3 DK1559779 T3 DK 1559779T3
Authority
DK
Denmark
Prior art keywords
modified
impdh polypeptide
histidine
tagged
inosine monophosphate
Prior art date
Application number
DK05001460T
Other languages
Danish (da)
English (en)
Inventor
Allan R Dorn
Janice E Rugaber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1559779T3 publication Critical patent/DK1559779T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
DK05001460T 2004-01-30 2005-01-25 Modificerede inosin-monophosphatdehydrogenaser DK1559779T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/769,481 US7276362B2 (en) 2004-01-30 2004-01-30 Recombinant histidine-tagged inosine monophosphate dehydrogenase polypeptides

Publications (1)

Publication Number Publication Date
DK1559779T3 true DK1559779T3 (da) 2009-06-22

Family

ID=34654391

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05001460T DK1559779T3 (da) 2004-01-30 2005-01-25 Modificerede inosin-monophosphatdehydrogenaser

Country Status (9)

Country Link
US (2) US7276362B2 (de)
EP (1) EP1559779B1 (de)
JP (2) JP4597689B2 (de)
AT (1) ATE424451T1 (de)
CA (1) CA2491887C (de)
DE (1) DE602005013013D1 (de)
DK (1) DK1559779T3 (de)
ES (1) ES2322477T3 (de)
PL (1) PL1559779T3 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473541B2 (en) * 2004-07-09 2009-01-06 Gross Richard W Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
US7183106B1 (en) * 2004-05-28 2007-02-27 The United States Of America As Represented By The United States Department Of Energy Bacterial inosine 5′-monophosphate dehydrogenase (“IMPDH”) DNA as a dominant selectable marker in mammals and other eukaryotes

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215051A (en) 1979-08-29 1980-07-29 Standard Oil Company (Indiana) Formation, purification and recovery of phthalic anhydride
US5047513A (en) * 1986-07-10 1991-09-10 Hoffmann-La Roche Inc. Metal chelate resins
CA1304886C (en) * 1986-07-10 1992-07-07 Heinz Dobeli Metal chelate resins
CA1340522C (en) * 1987-03-10 1999-05-04 Heinz Dobeli Fusion proteins containing neighbouring histidines for improved purification
US5665583A (en) * 1988-08-12 1997-09-09 Arch Dev Corp Methods and materials relating to IMPDH and GMP production
US5283257A (en) 1992-07-10 1994-02-01 The Board Of Trustees Of The Leland Stanford Junior University Method of treating hyperproliferative vascular disease
WO1994012184A1 (en) 1992-11-24 1994-06-09 Syntex (U.S.A.) Inc. Use of mycophenolic acid, mycophenolate mofetil or derivate thereof to inhibit stenosis
US5380879A (en) 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
US5444072A (en) 1994-02-18 1995-08-22 Syntex (U.S.A.) Inc. 6-substituted mycophenolic acid and derivatives
US5807876A (en) 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
US6128582A (en) * 1996-04-30 2000-10-03 Vertex Pharmaceuticals Incorporated Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
DE19811313A1 (de) 1998-03-16 1999-09-23 Merckle Gmbh Verfahren zur Bestimmung der Aktivität von Inosin 5'-monophosphat dehydrogenase
US6451572B1 (en) 1998-06-25 2002-09-17 Cornell Research Foundation, Inc. Overexpression of phytase genes in yeast systems
US6107052A (en) * 1999-06-09 2000-08-22 Roche Diagnostics Corporation Enzymatic measurement of mycophenolic acid
US6524808B1 (en) * 1999-06-25 2003-02-25 Roche Diagnostics Corporation Enzyme inhibition immunoassay
WO2001036607A1 (en) 1999-11-18 2001-05-25 Cornell Research Foundation, Inc. Site-directed mutagenesis of escherichia coli phytase
EP1282714A2 (de) 2000-05-10 2003-02-12 Bristol-Myers Squibb Company Modifizierte inosine- 5'-monophosphatdehydrogenase-polypeptide und verwendung davon
DE60140929D1 (de) 2000-11-14 2010-02-11 Roche Diagnostics Gmbh Immunoassay für HIV-Protease-Hemstoffe

Also Published As

Publication number Publication date
EP1559779B1 (de) 2009-03-04
US7531336B2 (en) 2009-05-12
PL1559779T3 (pl) 2009-08-31
US20080026424A1 (en) 2008-01-31
JP2010119395A (ja) 2010-06-03
ATE424451T1 (de) 2009-03-15
ES2322477T3 (es) 2009-06-22
US20050202520A1 (en) 2005-09-15
US7276362B2 (en) 2007-10-02
CA2491887C (en) 2010-03-30
CA2491887A1 (en) 2005-07-30
JP4597689B2 (ja) 2010-12-15
JP2005218447A (ja) 2005-08-18
EP1559779A1 (de) 2005-08-03
DE602005013013D1 (de) 2009-04-16

Similar Documents

Publication Publication Date Title
Benítez-Mateos et al. Self-sufficient flow-biocatalysis by coimmobilization of pyridoxal 5′-phosphate and ω-transaminases onto porous carriers
Nunn et al. Metabolism of pentose sugars in the hyperthermophilic archaea Sulfolobus solfataricus and Sulfolobus acidocaldarius
Wang et al. Cell-free protein synthesis energized by slowly-metabolized maltodextrin
Lubberink et al. Biocatalytic monoacylation of symmetrical diamines and its application to the synthesis of pharmaceutically relevant amides
DK1831362T3 (da) Syreaktive svampeproteaser
CY1107689T1 (el) Μεθοδοι και μεσα ελεγχου της σιαλιωσης πρωτεινων που παραγονται απο κυτταρα θηλαστικων
Westerbeek et al. Kinetic resolution of α‐Bromoamides: experimental and theoretical investigation of highly enantioselective reactions catalyzed by haloalkane dehalogenases
WO2004058990A3 (en) Genetic polymorphisms associated with stenosis, methods of detection and uses thereof
EP3586868A3 (de) Leberspezifische nukleinsäureregulatorische elemente sowie verfahren und verwendung davon
DE60228477D1 (de) Verfahren zur regulierung der immunfunktion in primaten unter verwendung des foxp3-proteins
BR0116033A (pt) Amplificação isotérmica de ácidos nucléicos sobre um suporte sólido
NO20075088L (no) Vertscelle omfattende en vektor for fremstilling av proteiner som krever gamma-karboksylering
TW200718778A (en) Polishing composition
McCarty et al. Escherichia coli QueD is a 6-carboxy-5, 6, 7, 8-tetrahydropterin synthase
IL180531A0 (en) Novel sequence for improving expression of nucleic acid
DE60313659D1 (de) Borrelidin-derivate und ihre medizinische anwendung
DK1602722T3 (da) Fremgangsmåde til fremstilling af mikrobiel transglutaminase
Lelièvre et al. ATP regeneration system in chemoenzymatic amide bond formation with thermophilic CoA ligase
Song et al. Proteorhodopsin overproduction enhances the long-term viability of Escherichia coli
ATE424451T1 (de) Modifizierte inosine-monophosphate dehydrogenasen
ATE483798T1 (de) Alkoholdehydrogenase zur stereoselektiven gewinnung von hydroxyverbindungen
DE602007010986D1 (de) Verwendung von acetalen zur isolation von nukleinsäuren
Tong et al. Novel affinity purification of monomeric sarcosine oxidase expressed in Escherichia coli
Krauser et al. Directed multistep biocatalysis for the synthesis of the polyketide oxytetracycline in permeabilized cells of escherichia coli
JP2015525560A5 (de)