DK1539815T3 - Krystalstruktur af et angiotensin-konverterende enzym (ACE) og anvendelser deraf - Google Patents

Krystalstruktur af et angiotensin-konverterende enzym (ACE) og anvendelser deraf

Info

Publication number
DK1539815T3
DK1539815T3 DK03750910T DK03750910T DK1539815T3 DK 1539815 T3 DK1539815 T3 DK 1539815T3 DK 03750910 T DK03750910 T DK 03750910T DK 03750910 T DK03750910 T DK 03750910T DK 1539815 T3 DK1539815 T3 DK 1539815T3
Authority
DK
Denmark
Prior art keywords
ace
applications
crystal structure
converting enzyme
angiotensin converting
Prior art date
Application number
DK03750910T
Other languages
Danish (da)
English (en)
Inventor
Ravi Acharya
Edward Sturrock
Original Assignee
Univ Bath
Univ Cape Town
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bath, Univ Cape Town filed Critical Univ Bath
Application granted granted Critical
Publication of DK1539815T3 publication Critical patent/DK1539815T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
DK03750910T 2002-09-12 2003-09-12 Krystalstruktur af et angiotensin-konverterende enzym (ACE) og anvendelser deraf DK1539815T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0221169.6A GB0221169D0 (en) 2002-09-12 2002-09-12 Crystal
PCT/GB2003/003966 WO2004024765A1 (en) 2002-09-12 2003-09-12 Crystal structure of an angiotensin-converting enzyme (ace) and uses thereof

Publications (1)

Publication Number Publication Date
DK1539815T3 true DK1539815T3 (da) 2009-05-11

Family

ID=9943936

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03750910T DK1539815T3 (da) 2002-09-12 2003-09-12 Krystalstruktur af et angiotensin-konverterende enzym (ACE) og anvendelser deraf

Country Status (11)

Country Link
US (3) US7704319B2 (de)
EP (1) EP1539815B1 (de)
AT (1) ATE421975T1 (de)
AU (1) AU2003269128B8 (de)
CA (1) CA2507621C (de)
DE (1) DE60326048D1 (de)
DK (1) DK1539815T3 (de)
GB (1) GB0221169D0 (de)
SI (1) SI1539815T1 (de)
WO (1) WO2004024765A1 (de)
ZA (1) ZA200502088B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0600406D0 (en) 2006-01-10 2006-02-15 Univ Bath Crystal
NZ621143A (en) * 2008-09-05 2016-08-26 Celgene Avilomics Res Inc Algorithm for designing irreversible inhibitors
IN2012DN02534A (de) 2009-09-16 2015-08-28 Avila Therapeutics Inc
AU2010339456A1 (en) * 2009-12-30 2012-07-05 Celgene Avilomics Research, Inc. Ligand-directed covalent modification of protein
WO2012162856A1 (en) * 2011-06-01 2012-12-06 Novo Nordisk A/S Crystal of cytokine receptor
EP3471623B1 (de) * 2016-06-20 2023-01-25 Butterfly Network, Inc. Automatische bilderfassung zur unterstützung eines benutzers beim betrieb einer ultraschallvorrichtung

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947575A (en) 1969-06-30 1976-03-30 E. R. Squibb & Sons, Inc. Peptides as argiotensin converting enzyme inhibitors
US3832337A (en) 1970-07-28 1974-08-27 Squibb & Sons Inc Peptide enzyme inhibitors
US3891616A (en) * 1974-04-17 1975-06-24 Squibb & Sons Inc Hypotensive {62 -homoaminoacid nonapeptides
ES441743A1 (es) * 1974-10-19 1977-03-16 Hoechst Ag Procedimiento para la obtencion de fibras e hilos de moda- crilico protegido contra las llamas con termoestabilidad me-jorada.
US4052511A (en) * 1976-02-13 1977-10-04 E. R. Squibb & Sons, Inc. Carboxyacylproline derivatives
US4053651A (en) 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
FR2649412B1 (fr) * 1989-07-05 1995-10-20 Inst Nat Sante Rech Med Acide nucleique codant pour l'enzyme de conversion de l'angiotensine (eca) testiculaire humaine, et ses applications, notamment pour le depistage in vitro de cette enzyme dans l'organisme
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
JPH03251543A (ja) * 1990-02-26 1991-11-11 Unitika Ltd アンジオテンシン変換酵素阻害剤
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
ES2340475T3 (es) * 2002-05-01 2010-06-04 Vertex Pharmaceuticals Incorporated Estructura cristalizada de proteina aurora-2 y sus bolsillos de union.
US20040033532A1 (en) * 2002-08-08 2004-02-19 Ehlers Mario R. W. Use of three-dimensional crystal structure coordinates to design and synthesize domain-selective inhibitors for angiotensin-converting enzyme (ACE)
WO2004023270A2 (en) * 2002-09-09 2004-03-18 Millenium Pharmaceuticals, Inc. Crystal structure of angiotensin-converting enzyme-related carboxypeptidase

Also Published As

Publication number Publication date
ZA200502088B (en) 2008-02-27
DE60326048D1 (de) 2009-03-19
WO2004024765A1 (en) 2004-03-25
WO2004024765A8 (en) 2006-01-05
SI1539815T1 (sl) 2009-06-30
US8594947B2 (en) 2013-11-26
US20090142822A1 (en) 2009-06-04
CA2507621C (en) 2020-02-25
US7704319B2 (en) 2010-04-27
AU2003269128B8 (en) 2010-02-25
CA2507621A1 (en) 2004-03-25
EP1539815A1 (de) 2005-06-15
GB0221169D0 (en) 2002-10-23
AU2003269128A1 (en) 2004-04-30
US20100160180A1 (en) 2010-06-24
US20060174816A1 (en) 2006-08-10
EP1539815B1 (de) 2009-01-28
US7901507B2 (en) 2011-03-08
ATE421975T1 (de) 2009-02-15
AU2003269128B2 (en) 2009-10-29

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