DK153954C - Fremgangsmaade til fremstilling af et monoklonalt antistof, hybridomacellelinie til anvendelse ved fremgangsmaaden samt fremgangsmaade til diagnose og diagnostisk praeparat med det fremstillede monoklonale antistof - Google Patents
Fremgangsmaade til fremstilling af et monoklonalt antistof, hybridomacellelinie til anvendelse ved fremgangsmaaden samt fremgangsmaade til diagnose og diagnostisk praeparat med det fremstillede monoklonale antistofInfo
- Publication number
- DK153954C DK153954C DK517380A DK517380A DK153954C DK 153954 C DK153954 C DK 153954C DK 517380 A DK517380 A DK 517380A DK 517380 A DK517380 A DK 517380A DK 153954 C DK153954 C DK 153954C
- Authority
- DK
- Denmark
- Prior art keywords
- procedure
- preparation
- monoclonal antibody
- cell line
- monoclon
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hybrid Cells (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/100,072 US4364935A (en) | 1979-12-04 | 1979-12-04 | Monoclonal antibody to a human prothymocyte antigen and methods of preparing same |
US10007279 | 1979-12-04 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK517380A DK517380A (da) | 1981-06-05 |
DK153954B DK153954B (da) | 1988-09-26 |
DK153954C true DK153954C (da) | 1989-02-20 |
Family
ID=22277974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK517380A DK153954C (da) | 1979-12-04 | 1980-12-03 | Fremgangsmaade til fremstilling af et monoklonalt antistof, hybridomacellelinie til anvendelse ved fremgangsmaaden samt fremgangsmaade til diagnose og diagnostisk praeparat med det fremstillede monoklonale antistof |
Country Status (22)
Country | Link |
---|---|
US (1) | US4364935A (fr) |
EP (1) | EP0030815B1 (fr) |
JP (2) | JPS5695123A (fr) |
AT (1) | ATE13317T1 (fr) |
AU (1) | AU545223B2 (fr) |
CA (1) | CA1183470A (fr) |
DE (2) | DE30815T1 (fr) |
DK (1) | DK153954C (fr) |
ES (1) | ES8303097A1 (fr) |
FI (1) | FI75365C (fr) |
GR (1) | GR72923B (fr) |
HK (1) | HK24386A (fr) |
IE (1) | IE50725B1 (fr) |
IL (1) | IL61624A (fr) |
MY (1) | MY8600519A (fr) |
NO (1) | NO159888C (fr) |
NZ (1) | NZ195647A (fr) |
PH (1) | PH17510A (fr) |
PT (1) | PT72146B (fr) |
SG (1) | SG7386G (fr) |
YU (1) | YU45078B (fr) |
ZA (1) | ZA807567B (fr) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4806349A (en) * | 1979-12-04 | 1989-02-21 | Ortho Pharmaceutical Corporation | Hybrid cell line for producing monoclonal antibody to a human prothymocyte antigen, antibody, and methods |
US4582797A (en) * | 1980-09-25 | 1986-04-15 | The Salk Institute For Biological Studies | Monoclonal antibodies specific for human hematopoietic cell surface glycoproteins |
JPS5823847B2 (ja) * | 1981-02-06 | 1983-05-18 | 株式会社 林原生物化学研究所 | 抗ヒト蛋白質抗体の製造方法 |
DE3105150A1 (de) * | 1981-02-12 | 1982-08-19 | Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg | Herstellung von anti-t-lymphozyten-globulin. |
US4434156A (en) | 1981-10-26 | 1984-02-28 | The Salk Institute For Biological Studies | Monoclonal antibodies specific for the human transferrin receptor glycoprotein |
USRE32011E (en) * | 1981-12-14 | 1985-10-22 | Scripps Clinic And Research Foundation | Ultrapurification of factor VIII using monoclonal antibodies |
AU555146B2 (en) * | 1982-03-15 | 1986-09-11 | Trustees Of Columbia University In The City Of New York, The | Method for intorducing cloned, amplifiable genes into eucaryotic cells and for producing proteinaceous products materials |
US4443427A (en) * | 1982-06-21 | 1984-04-17 | Sidney Farber Cancer Institute, Inc. | Monoclonal antibody |
US4579827A (en) * | 1983-03-11 | 1986-04-01 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies to human gastrointestinal cancers and hybridoma method of production of the monoclonal antibodies |
JPS60231699A (ja) * | 1983-11-09 | 1985-11-18 | Aichiken | 正常及び悪性ヒト造血器細胞に対するモノクローナル抗体 |
FR2560212B1 (fr) * | 1984-02-24 | 1989-12-29 | Unicet | Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps |
US5431897A (en) * | 1985-04-19 | 1995-07-11 | Sloan-Kettering Institute For Cancer Research | Method of imaging colorectal carcinoma lesion and composition for use therein |
US4705687A (en) * | 1985-06-17 | 1987-11-10 | Ortho Pharmaceutical (Canada) Ltd. | Treatment of autoimmune diseases such as rheumatoid arthritis with suppressor factor |
US4970299A (en) * | 1986-07-03 | 1990-11-13 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies selective for prostate cancer |
US5601819A (en) * | 1988-08-11 | 1997-02-11 | The General Hospital Corporation | Bispecific antibodies for selective immune regulation and for selective immune cell binding |
US6498006B2 (en) | 1997-11-24 | 2002-12-24 | Johnson T. Wong | Methods for treatment of HIV and other infections using A T cell or viral activator and anti-retroviral combination therapy |
FR2878852B1 (fr) * | 2000-09-28 | 2007-02-23 | Imtix Sangstat | Procede de production d'immunoglobulines anti-thymocytes humains |
US7653260B2 (en) | 2004-06-17 | 2010-01-26 | Carl Zeis MicroImaging GmbH | System and method of registering field of view |
US8582924B2 (en) | 2004-06-30 | 2013-11-12 | Carl Zeiss Microimaging Gmbh | Data structure of an image storage and retrieval system |
EP2061505B9 (fr) * | 2006-09-01 | 2013-04-03 | Genticel | Composition pour éliciter une réponse ctl spécifique, comprenant un composé lympho-ablatif et une molécule contenant des séquences antigéniques et ciblant des cellules présentant des antigènes spécialisés |
WO2011028952A1 (fr) | 2009-09-02 | 2011-03-10 | Xencor, Inc. | Compositions et procédés pour une co-liaison bivalente et monovalente simultanée d'antigènes |
WO2012016227A2 (fr) | 2010-07-29 | 2012-02-02 | Xencor, Inc. | Anticorps dont les points isoélectriques sont modifiés |
US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
AU2014205086B2 (en) | 2013-01-14 | 2019-04-18 | Xencor, Inc. | Novel heterodimeric proteins |
US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
EP2945969A1 (fr) | 2013-01-15 | 2015-11-25 | Xencor, Inc. | Elimination rapide de complexes antigéniques à l'aide de nouveaux anticorps |
EP2970486B1 (fr) | 2013-03-15 | 2018-05-16 | Xencor, Inc. | Modulation de cellules t avec des anticorps bispecifiques et des fusions fc |
US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
WO2015123687A1 (fr) | 2014-02-14 | 2015-08-20 | Centrose, Llc | Conjugués de médicaments à ciblage extracellulaire |
RS59907B1 (sr) | 2014-03-28 | 2020-03-31 | Xencor Inc | Bispecifična antitela koja se vezuju za cd38 i cd3 |
US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
CA2968878A1 (fr) | 2014-11-26 | 2016-06-02 | Xencor, Inc. | Anticorps heterodimeriques se liant aux antigenes cd3 et cd38 |
RS62332B1 (sr) | 2014-11-26 | 2021-10-29 | Xencor Inc | Heterodimerna antitela koja vezuju cd3 i cd20 |
WO2016105450A2 (fr) | 2014-12-22 | 2016-06-30 | Xencor, Inc. | Anticorps trispécifiques |
WO2016141387A1 (fr) | 2015-03-05 | 2016-09-09 | Xencor, Inc. | Modulation de lymphocytes t avec des anticorps bispécifiques et des hybrides fc |
EP3387013B1 (fr) | 2015-12-07 | 2022-06-08 | Xencor, Inc. | Anticorps hétérodimères se liant à cd3 et psma |
US10787518B2 (en) | 2016-06-14 | 2020-09-29 | Xencor, Inc. | Bispecific checkpoint inhibitor antibodies |
WO2018005706A1 (fr) | 2016-06-28 | 2018-01-04 | Xencor, Inc. | Anticorps hétérodimériques qui se lient au récepteur 2 de la somatostatine |
US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
US10550185B2 (en) | 2016-10-14 | 2020-02-04 | Xencor, Inc. | Bispecific heterodimeric fusion proteins containing IL-15-IL-15Rα Fc-fusion proteins and PD-1 antibody fragments |
JP2020529832A (ja) | 2017-06-30 | 2020-10-15 | ゼンコア インコーポレイテッド | IL−15/IL−15Rαおよび抗原結合ドメインを含む標的化ヘテロダイマーFc融合タンパク質 |
WO2019094637A1 (fr) | 2017-11-08 | 2019-05-16 | Xencor, Inc. | Anticorps bispécifiques et monospécifiques utilisant de nouvelles séquences anti-pd-1 |
US10981992B2 (en) | 2017-11-08 | 2021-04-20 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
CN111655718A (zh) | 2017-12-19 | 2020-09-11 | Xencor股份有限公司 | 经过工程化的il-2 fc融合蛋白 |
AU2019247415A1 (en) | 2018-04-04 | 2020-10-22 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
MX2020010910A (es) | 2018-04-18 | 2021-02-09 | Xencor Inc | Proteinas de fusion heterodimericas dirigidas a pd-1 que contienen proteinas de fusion il-15 / il-15ra fc y dominios de union al antigeno pd-1 y usos de los mismos. |
WO2019204655A1 (fr) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Protéines de fusion hétérodimères ciblant tim-3 contenant des protéines de fusion fc d'il-15/il-15ra et domaines de liaison à l'antigène de tim-3 |
JP2022503959A (ja) | 2018-10-03 | 2022-01-12 | ゼンコア インコーポレイテッド | Il-12ヘテロ二量体fc-融合タンパク質 |
US11472890B2 (en) | 2019-03-01 | 2022-10-18 | Xencor, Inc. | Heterodimeric antibodies that bind ENPP3 and CD3 |
US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
AU2022232375A1 (en) | 2021-03-09 | 2023-09-21 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
EP4305065A1 (fr) | 2021-03-10 | 2024-01-17 | Xencor, Inc. | Anticorps hétérodimères qui se lient au cd3 et au gpc3 |
CN114085818A (zh) * | 2021-11-19 | 2022-02-25 | 蔡开来 | 一种抗大熊猫Thy1单克隆抗体及其杂交瘤细胞株和应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4196265A (en) * | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
US4172124A (en) * | 1978-04-28 | 1979-10-23 | The Wistar Institute | Method of producing tumor antibodies |
US4284412A (en) * | 1979-07-13 | 1981-08-18 | Ortho Diagnostics, Inc. | Method and apparatus for automated identification and enumeration of specified blood cell subclasses |
-
1979
- 1979-12-04 US US06/100,072 patent/US4364935A/en not_active Expired - Lifetime
-
1980
- 1980-11-21 CA CA000365175A patent/CA1183470A/fr not_active Expired
- 1980-11-25 NZ NZ195647A patent/NZ195647A/en unknown
- 1980-12-02 GR GR63536A patent/GR72923B/el unknown
- 1980-12-03 FI FI803757A patent/FI75365C/fi not_active IP Right Cessation
- 1980-12-03 EP EP80304350A patent/EP0030815B1/fr not_active Expired
- 1980-12-03 DE DE198080304350T patent/DE30815T1/de active Pending
- 1980-12-03 ES ES497425A patent/ES8303097A1/es not_active Expired
- 1980-12-03 IL IL61624A patent/IL61624A/xx not_active IP Right Cessation
- 1980-12-03 PT PT72146A patent/PT72146B/pt unknown
- 1980-12-03 AU AU65012/80A patent/AU545223B2/en not_active Expired
- 1980-12-03 AT AT80304350T patent/ATE13317T1/de not_active IP Right Cessation
- 1980-12-03 IE IE2511/80A patent/IE50725B1/en not_active IP Right Cessation
- 1980-12-03 ZA ZA00807567A patent/ZA807567B/xx unknown
- 1980-12-03 YU YU3067/80A patent/YU45078B/xx unknown
- 1980-12-03 PH PH24938A patent/PH17510A/en unknown
- 1980-12-03 DE DE8080304350T patent/DE3070655D1/de not_active Expired
- 1980-12-03 NO NO803661A patent/NO159888C/no not_active IP Right Cessation
- 1980-12-03 DK DK517380A patent/DK153954C/da not_active IP Right Cessation
- 1980-12-04 JP JP17032780A patent/JPS5695123A/ja active Granted
-
1986
- 1986-01-23 SG SG73/86A patent/SG7386G/en unknown
- 1986-04-03 HK HK243/86A patent/HK24386A/xx not_active IP Right Cessation
- 1986-12-30 MY MY519/86A patent/MY8600519A/xx unknown
-
1988
- 1988-05-17 JP JP63118392A patent/JPS6413988A/ja active Granted
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Legal Events
Date | Code | Title | Description |
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PUP | Patent expired |