DK151019C - Analogifremgangsmaade til fremstilling af 1-(3-(6-fluor-1,2-benzisoxazol-3-yl)propyl)-4-hydroxy-4-phenylpiperidiner, samt 3-(gamma-chlorpropyl)-6-fluor-1,2-benzisoxazol til anvendelse herved - Google Patents

Analogifremgangsmaade til fremstilling af 1-(3-(6-fluor-1,2-benzisoxazol-3-yl)propyl)-4-hydroxy-4-phenylpiperidiner, samt 3-(gamma-chlorpropyl)-6-fluor-1,2-benzisoxazol til anvendelse herved

Info

Publication number
DK151019C
DK151019C DK186182A DK186182A DK151019C DK 151019 C DK151019 C DK 151019C DK 186182 A DK186182 A DK 186182A DK 186182 A DK186182 A DK 186182A DK 151019 C DK151019 C DK 151019C
Authority
DK
Denmark
Prior art keywords
fluor
benzisoxazol
benzisoxazole
chloropropyl
gamma
Prior art date
Application number
DK186182A
Other languages
Danish (da)
English (en)
Other versions
DK186182A (da
DK151019B (da
Inventor
Larry Davis
Richard Charles Effland
Joseph T Klein
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/366,247 external-priority patent/US4396770A/en
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of DK186182A publication Critical patent/DK186182A/da
Publication of DK151019B publication Critical patent/DK151019B/da
Application granted granted Critical
Publication of DK151019C publication Critical patent/DK151019C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK186182A 1981-04-27 1982-04-26 Analogifremgangsmaade til fremstilling af 1-(3-(6-fluor-1,2-benzisoxazol-3-yl)propyl)-4-hydroxy-4-phenylpiperidiner, samt 3-(gamma-chlorpropyl)-6-fluor-1,2-benzisoxazol til anvendelse herved DK151019C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25769881A 1981-04-27 1981-04-27
US25769881 1981-04-27
US06/366,247 US4396770A (en) 1982-04-09 1982-04-09 1-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-4-hydroxy-4-phenylpiperidines
US36624782 1982-04-09

Publications (3)

Publication Number Publication Date
DK186182A DK186182A (da) 1982-10-28
DK151019B DK151019B (da) 1987-10-12
DK151019C true DK151019C (da) 1988-03-14

Family

ID=26946142

Family Applications (1)

Application Number Title Priority Date Filing Date
DK186182A DK151019C (da) 1981-04-27 1982-04-26 Analogifremgangsmaade til fremstilling af 1-(3-(6-fluor-1,2-benzisoxazol-3-yl)propyl)-4-hydroxy-4-phenylpiperidiner, samt 3-(gamma-chlorpropyl)-6-fluor-1,2-benzisoxazol til anvendelse herved

Country Status (10)

Country Link
EP (2) EP0063799B1 (fr)
AU (1) AU564572B2 (fr)
DE (1) DE3267658D1 (fr)
DK (1) DK151019C (fr)
FI (1) FI821415L (fr)
GR (1) GR75417B (fr)
IL (1) IL65598A (fr)
NO (1) NO821361L (fr)
NZ (1) NZ200400A (fr)
PT (1) PT74799B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4420485A (en) * 1982-09-29 1983-12-13 Hoechst-Roussel Pharmaceuticals Inc. 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines]
FR2588860B1 (fr) * 1985-10-21 1988-08-12 Isochem Sa (chloro-3 propionyl)-2 fluoro-4 phenol, procede pour sa preparation, et application a la preparation de la fluoro-6 chromanone-4
US5114936A (en) * 1990-08-23 1992-05-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51136666A (en) * 1975-05-19 1976-11-26 Dainippon Pharmaceut Co Ltd Process for preparing 3-aminoalkyl-1,2-benzisoxazole derivatives.
JPS54136666A (en) * 1978-04-15 1979-10-23 Matsushita Electric Works Ltd Leakage breaker
JPS6043064B2 (ja) * 1979-11-28 1985-09-26 ウェルファイド株式会社 新規イソオキサゾ−ル誘導体

Also Published As

Publication number Publication date
FI821415A0 (fi) 1982-04-23
EP0063799A3 (en) 1982-12-15
GR75417B (fr) 1984-07-16
EP0063799B1 (fr) 1985-11-27
IL65598A0 (en) 1982-07-30
NZ200400A (en) 1987-04-30
AU8300482A (en) 1982-11-04
FI821415L (fi) 1982-10-28
DK186182A (da) 1982-10-28
EP0149229B1 (fr) 1989-06-14
EP0149229A3 (en) 1986-10-29
EP0149229A2 (fr) 1985-07-24
DE3267658D1 (en) 1986-01-09
DK151019B (da) 1987-10-12
EP0063799A2 (fr) 1982-11-03
AU564572B2 (en) 1987-08-20
PT74799B (en) 1984-06-27
IL65598A (en) 1985-12-31
NO821361L (no) 1982-10-28
PT74799A (en) 1982-05-01

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