DK1501828T3 - Piperazinbenzothiazoler som midler til behandling af cerebrale iskæmiske lidelser eller CNS-lidelser - Google Patents

Piperazinbenzothiazoler som midler til behandling af cerebrale iskæmiske lidelser eller CNS-lidelser

Info

Publication number
DK1501828T3
DK1501828T3 DK03727365T DK03727365T DK1501828T3 DK 1501828 T3 DK1501828 T3 DK 1501828T3 DK 03727365 T DK03727365 T DK 03727365T DK 03727365 T DK03727365 T DK 03727365T DK 1501828 T3 DK1501828 T3 DK 1501828T3
Authority
DK
Denmark
Prior art keywords
piperazine
treatment
benzothiazoles
agents
cerebral ischemic
Prior art date
Application number
DK03727365T
Other languages
Danish (da)
English (en)
Inventor
Jean-Pierre Gotteland
Pierre-Alain Vitte
P Gaillard
Original Assignee
Serono Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serono Lab filed Critical Serono Lab
Application granted granted Critical
Publication of DK1501828T3 publication Critical patent/DK1501828T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK03727365T 2002-04-25 2003-04-25 Piperazinbenzothiazoler som midler til behandling af cerebrale iskæmiske lidelser eller CNS-lidelser DK1501828T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02100417 2002-04-25
PCT/EP2003/004323 WO2003091249A1 (en) 2002-04-25 2003-04-25 Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or cns disorders

Publications (1)

Publication Number Publication Date
DK1501828T3 true DK1501828T3 (da) 2008-03-10

Family

ID=29265991

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03727365T DK1501828T3 (da) 2002-04-25 2003-04-25 Piperazinbenzothiazoler som midler til behandling af cerebrale iskæmiske lidelser eller CNS-lidelser

Country Status (23)

Country Link
US (1) US7314878B2 (pt)
EP (1) EP1501828B1 (pt)
JP (1) JP4523289B2 (pt)
KR (1) KR100948469B1 (pt)
CN (1) CN1310911C (pt)
AT (1) ATE383356T1 (pt)
AU (1) AU2003233067B2 (pt)
BR (1) BRPI0309594A8 (pt)
CA (1) CA2481763C (pt)
CY (1) CY1107204T1 (pt)
DE (1) DE60318567T2 (pt)
DK (1) DK1501828T3 (pt)
EA (1) EA009682B1 (pt)
ES (1) ES2297165T3 (pt)
HK (1) HK1075664A1 (pt)
IL (2) IL164796A0 (pt)
MX (1) MXPA04010474A (pt)
PT (1) PT1501828E (pt)
RS (1) RS51407B (pt)
SI (1) SI1501828T1 (pt)
UA (1) UA78035C2 (pt)
WO (1) WO2003091249A1 (pt)
ZA (1) ZA200408023B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60318567T2 (de) 2002-04-25 2009-02-19 Laboratoires Serono S.A., Coinsins Piperazinbenzothiazole als wirkstoffe in der behandlung von ischämien und krankheiten des zns-systems
PT1696909E (pt) * 2003-09-12 2007-12-21 Serono Lab Derivados benzotiazolo para o tratamento de diabetes
WO2005118543A1 (ja) * 2004-06-03 2005-12-15 Ono Pharmaceutical Co., Ltd. キナーゼ阻害薬およびその用途
US7838522B2 (en) 2004-11-17 2010-11-23 Ares Trading S.A. Benzothiazole formulations and use thereof
ES2315931T3 (es) * 2004-11-17 2009-04-01 Ares Trading S.A. Formulaciones de benzotiazol y su uso.
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 jnk 억제제
BRPI0613042A2 (pt) * 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
US20100121057A1 (en) * 2007-04-17 2010-05-13 Merck Serono Sa Process for the Preparation of Piperazine Benzothiazoles
RU2504545C2 (ru) * 2008-05-16 2014-01-20 Ф. Хоффманн-Ля Рош Аг Ингибиторы jnk
KR101800916B1 (ko) * 2010-06-04 2017-11-23 에프. 호프만-라 로슈 아게 Jnk 억제제로서 유용한 2-아미노-피리미딘 유도체
US8471027B2 (en) * 2011-04-06 2013-06-25 Hoffmann-La Roche Inc. Adamantyl compounds
CN104903331A (zh) * 2013-01-24 2015-09-09 山东亨利医药科技有限责任公司 Jnk抑制剂

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4153574B2 (ja) * 1997-09-10 2008-09-24 トーアエイヨー株式会社 新規なピペリジン誘導体、その製造法およびそれを含有する循環器官用剤
EP1110957A1 (en) * 1999-12-24 2001-06-27 Applied Research Systems ARS Holding N.V. Benzazole derivatives and their use as JNK modulators
EP1193256A1 (en) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins
DE60318567T2 (de) 2002-04-25 2009-02-19 Laboratoires Serono S.A., Coinsins Piperazinbenzothiazole als wirkstoffe in der behandlung von ischämien und krankheiten des zns-systems

Also Published As

Publication number Publication date
EP1501828B1 (en) 2008-01-09
IL164796A0 (en) 2005-12-18
PT1501828E (pt) 2008-02-11
CN1662528A (zh) 2005-08-31
ZA200408023B (en) 2005-11-30
JP2006504631A (ja) 2006-02-09
RS92804A (en) 2006-12-15
AU2003233067A1 (en) 2003-11-10
EA200401423A1 (ru) 2005-04-28
ES2297165T3 (es) 2008-05-01
AU2003233067B2 (en) 2009-01-08
MXPA04010474A (es) 2004-12-13
CA2481763A1 (en) 2003-11-06
RS51407B (en) 2011-02-28
WO2003091249A1 (en) 2003-11-06
JP4523289B2 (ja) 2010-08-11
US20050261304A1 (en) 2005-11-24
BRPI0309594A2 (pt) 2016-11-16
HK1075664A1 (en) 2005-12-23
UA78035C2 (en) 2007-02-15
IL164796A (en) 2013-02-28
BRPI0309594A8 (pt) 2017-04-11
CN1310911C (zh) 2007-04-18
DE60318567D1 (de) 2008-02-21
ATE383356T1 (de) 2008-01-15
DE60318567T2 (de) 2009-02-19
CY1107204T1 (el) 2012-11-21
SI1501828T1 (sl) 2008-04-30
EP1501828A1 (en) 2005-02-02
US7314878B2 (en) 2008-01-01
EA009682B1 (ru) 2008-02-28
CA2481763C (en) 2011-06-14
KR20040104572A (ko) 2004-12-10
KR100948469B1 (ko) 2010-03-17

Similar Documents

Publication Publication Date Title
HK1075664A1 (en) Piperazine benzothiazoles as agents for the treatment of cerebral ischemic disorders or cns disorders
DK1789398T3 (da) 2-amino-quinazolin derivater anvendelige som inhibitorer af B-sekretase (BACE)
DE60332433D1 (de) Azolylaminoazine als proteinkinasehemmer
DE60332604D1 (de) Azolylaminoazine als proteinkinasehemmer
DK1776349T3 (da) 2-amino-puinazolin derivater anvendelige som inhibitorer af beta-sekretase (BACE)
DE60314603D1 (de) Zusammensetzungen brauchbar als protein-kinase- inhibitoren
NO20052595L (no) Sammensetninger anvendelige som inhibitorer av ROCK- og andre proteinkinaser.
DK1242415T3 (da) 3-thiazol-4-yl-pyrolidinderivater som AMP-specifikke phosphodiesteraseinhibitorer
NO20050514L (no) Sammensetning og antiviral aktivitet til substituerte azaindoloksoeddikpiperazinderivater
ATE433973T1 (de) Azolylaminoazine als inhibitoren von proteinkinasen
NO20062020L (no) 1-amino-2-oksysubstituerte tetrahydronaftalenderivater, fremgangsmate for fremstilling derav, og deres anvendelse som antiflogistika
DE602004014117D1 (de) Thiazole zur verwendung als inhibitoren von protein-kinasen
NO20054905L (no) 2-acylamino-4-fenyltiazolderivater, fremgangsmate for deres fremstilling og anvendelse av de samme som i terapeutika
NO20054848L (no) Substituerte p-diaminobenzenderivater
NO20082673L (no) Nye 2-amino-imidazol-4-on forbindelser og deres anvendelse i fremstilling av et medikament som skal brukes til behandling av kognitiv svekkelse, Alzheimers sykdom, neurodegenerasjon og demens
UY30025A1 (es) Derivados sustituidos de las 2-amino-5,6-dihidro pirimidin-4(3h)-onas y sus sales farmacéuticamente aceptables, composiciones farmacéuticas conteniéndolos y aplicaciones.
DE602004024572D1 (de) Zusammensetzungen, die sich als inhibitoren von proteinkinasen eignen
NO20050701L (no) 4-pyrrolidino-fenyl-benzyleter derivater
ECSP055844A (es) Nuevos compuestos triciclicos
DE602004012578D1 (de) Als inhibitoren von c-met geeignete pyrrolzusammensetzungen
NO20082679L (no) Sammensetning og fremgangsmate for a behandle CNS lidelser
NO20054721L (no) Substituerte anilinderivater
ATE440836T1 (de) Verbindungen
DK1751105T3 (da) Piperazinderivater af alkyloxindoler
NO20050146L (no) N,N-disubstituerte diazocykloalkaner nyttige i behandling av CNS-forstyrrelser grunnet serotonergisk dysfunksjon