DK1392822T3 - Dobbelttransficeret cellelinie anvendelig til identifikation af transporthæmmere - Google Patents

Dobbelttransficeret cellelinie anvendelig til identifikation af transporthæmmere

Info

Publication number
DK1392822T3
DK1392822T3 DK02738151.6T DK02738151T DK1392822T3 DK 1392822 T3 DK1392822 T3 DK 1392822T3 DK 02738151 T DK02738151 T DK 02738151T DK 1392822 T3 DK1392822 T3 DK 1392822T3
Authority
DK
Denmark
Prior art keywords
identification
cell line
transfected cell
transport inhibitors
line useful
Prior art date
Application number
DK02738151.6T
Other languages
English (en)
Inventor
Yunhai Cui
Joerg Koenig
Dietrich Keppler
Original Assignee
Deutsches Krebsforsch
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch, Boehringer Ingelheim Int filed Critical Deutsches Krebsforsch
Application granted granted Critical
Publication of DK1392822T3 publication Critical patent/DK1392822T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK02738151.6T 2001-06-06 2002-06-05 Dobbelttransficeret cellelinie anvendelig til identifikation af transporthæmmere DK1392822T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01113805A EP1264880A1 (en) 2001-06-06 2001-06-06 Double-transfected cell line useful for the identification of transport inhibitors
PCT/EP2002/006175 WO2002099088A1 (en) 2001-06-06 2002-06-05 Double-transfected cell line useful for the identification of transport inhibitors

Publications (1)

Publication Number Publication Date
DK1392822T3 true DK1392822T3 (da) 2013-06-10

Family

ID=8177655

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02738151.6T DK1392822T3 (da) 2001-06-06 2002-06-05 Dobbelttransficeret cellelinie anvendelig til identifikation af transporthæmmere

Country Status (8)

Country Link
US (1) US7229825B2 (da)
EP (3) EP1264880A1 (da)
JP (2) JP4387186B2 (da)
CY (1) CY1114402T1 (da)
DK (1) DK1392822T3 (da)
ES (1) ES2411960T3 (da)
PT (1) PT1392822E (da)
WO (1) WO2002099088A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004018608A1 (de) * 2004-04-16 2005-11-10 Aventis Pharma Deutschland Gmbh Doppelt transfizierte Zellinien als in-vitro-Screening-Werkzeuge zur Erstellung von Profilen pharmazeutischer Verbindungen:Ein Modell für die hepatobiläre Elimination
EP1645627A1 (en) * 2004-10-07 2006-04-12 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Quadruple transformed cell line useful for the identification of transport inhibitors
JP5830085B2 (ja) * 2011-03-10 2015-12-09 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｏａｔｐ１ｂ１の輸送活性を促進又は阻害する化合物をスクリーニングするための方法、及びｏａｔｐ１ｂ１発現量を測定するための方法
PL3736329T3 (pl) 2012-09-11 2022-07-18 Corning Incorporated Zużywalne krioprezerwowane komórki wykazujące przejściową nadekspresję genu(-ów) kodującego(-ych) białko(-a) transportera leku i/lub enzym(y) metabolizujący(-e) lek
WO2014200816A1 (en) 2013-06-14 2014-12-18 Biotranex, Llc Method for measuring bile salt export transport and/or formation activity
EP3380619A1 (en) * 2015-11-25 2018-10-03 Corning Incorporated Systems and methods for expressing proteins
CN109652448B (zh) * 2018-12-29 2021-03-12 苏州大学 人源oat1-mrp2-ugt2b7三重稳定转染细胞株及其构建方法
CN110229825B (zh) * 2019-06-04 2021-02-09 西南大学 水稻灰褐叶色突变gbl1基因及其应用

Also Published As

Publication number Publication date
PT1392822E (pt) 2013-06-17
EP2292738A1 (en) 2011-03-09
JP4387186B2 (ja) 2009-12-16
ES2411960T3 (es) 2013-07-09
EP1392822B1 (en) 2013-03-13
JP2004534538A (ja) 2004-11-18
EP1392822A1 (en) 2004-03-03
US20050003538A1 (en) 2005-01-06
US7229825B2 (en) 2007-06-12
CY1114402T1 (el) 2016-08-31
JP2009225797A (ja) 2009-10-08
WO2002099088A1 (en) 2002-12-12
EP1264880A1 (en) 2002-12-11

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