DK1345609T3 - Tetrahydro-(benzo eller thieno)-azepin-pyrazin- og triazinderivater som mGluR-1-antagonister - Google Patents
Tetrahydro-(benzo eller thieno)-azepin-pyrazin- og triazinderivater som mGluR-1-antagonisterInfo
- Publication number
- DK1345609T3 DK1345609T3 DK01271999T DK01271999T DK1345609T3 DK 1345609 T3 DK1345609 T3 DK 1345609T3 DK 01271999 T DK01271999 T DK 01271999T DK 01271999 T DK01271999 T DK 01271999T DK 1345609 T3 DK1345609 T3 DK 1345609T3
- Authority
- DK
- Denmark
- Prior art keywords
- mglur
- azepine
- thieno
- pyrazine
- benzo
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 125000005605 benzo group Chemical group 0.000 title 1
- 150000003918 triazines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00128329 | 2000-12-22 | ||
| EP01271999A EP1345609B1 (de) | 2000-12-22 | 2001-12-11 | Tetrahydro-(benzo- oder thieno-)azepin-pyrazin und triazinderivative als mglur 1 antagonisten |
| PCT/EP2001/014527 WO2002051418A1 (en) | 2000-12-22 | 2001-12-11 | Tetrahydro-(benzo or thieno)-azepine-pyrazine and triazine derivatives as mglur 1 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1345609T3 true DK1345609T3 (da) | 2005-10-03 |
Family
ID=8170787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01271999T DK1345609T3 (da) | 2000-12-22 | 2001-12-11 | Tetrahydro-(benzo eller thieno)-azepin-pyrazin- og triazinderivater som mGluR-1-antagonister |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6586422B2 (de) |
| EP (1) | EP1345609B1 (de) |
| JP (1) | JP4077319B2 (de) |
| KR (1) | KR100545906B1 (de) |
| CN (1) | CN1260226C (de) |
| AR (1) | AR032379A1 (de) |
| AT (1) | ATE297734T1 (de) |
| AU (1) | AU2002216095B2 (de) |
| BR (1) | BR0116378A (de) |
| CA (1) | CA2432077C (de) |
| DE (1) | DE60111568T2 (de) |
| DK (1) | DK1345609T3 (de) |
| ES (1) | ES2243400T3 (de) |
| MX (1) | MXPA03005515A (de) |
| PT (1) | PT1345609E (de) |
| WO (1) | WO2002051418A1 (de) |
| ZA (1) | ZA200304557B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2258358A3 (de) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
| EP2275095A3 (de) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenese durch modulation des Muscarinrezeptors |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US7893051B2 (en) | 2006-01-19 | 2011-02-22 | Athersys, Inc. | Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| JP2009536667A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | ５ｈｔ受容体介在性の神経新生 |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| KR20090064418A (ko) | 2006-09-08 | 2009-06-18 | 브레인셀즈 인코퍼레이션 | 4-아실아미노피리딘 유도체 포함 조합물 |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| KR101100864B1 (ko) * | 2009-06-12 | 2012-01-02 | 양준호 | 자동차 광택기용 광택패드 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3136654A1 (de) | 1981-09-16 | 1983-03-31 | Zahnradfabrik Friedrichshafen Ag, 7990 Friedrichshafen | Linearverschieblicher arbeitsarm, insbesondere fuer handhabungsgeraete |
| AU2642699A (en) * | 1998-03-03 | 1999-09-20 | Yamanouchi Pharmaceutical Co., Ltd. | Remedies for brain infarction |
| DK1117403T3 (da) * | 1998-10-02 | 2004-04-13 | Sibia Neurosciences Inc | MGLUR5-antagonister til behandling af smerte og angst |
| GB9823847D0 (en) * | 1998-11-02 | 1998-12-23 | Lilly Co Eli | Pharmaceutical compounds |
| EP1074549B1 (de) * | 1999-08-06 | 2003-11-19 | F. Hoffmann-La Roche Ag | Tetrahydro-benzo(d)azepine und deren Verwendung als metabotrope Glutamatrezeptor-Antagonisten |
| DE60006618T2 (de) * | 1999-08-06 | 2004-09-23 | F. Hoffmann-La Roche Ag | Tetrahydro-benzo(d)azepine und deren Verwendung als metabotrope Glutamatrezeptor-Antagonisten |
-
2001
- 2001-12-11 CA CA2432077A patent/CA2432077C/en not_active Expired - Fee Related
- 2001-12-11 CN CNB018222099A patent/CN1260226C/zh not_active Expired - Fee Related
- 2001-12-11 AU AU2002216095A patent/AU2002216095B2/en not_active Ceased
- 2001-12-11 MX MXPA03005515A patent/MXPA03005515A/es active IP Right Grant
- 2001-12-11 WO PCT/EP2001/014527 patent/WO2002051418A1/en active IP Right Grant
- 2001-12-11 ES ES01271999T patent/ES2243400T3/es not_active Expired - Lifetime
- 2001-12-11 JP JP2002552562A patent/JP4077319B2/ja not_active Expired - Fee Related
- 2001-12-11 EP EP01271999A patent/EP1345609B1/de not_active Expired - Lifetime
- 2001-12-11 DE DE60111568T patent/DE60111568T2/de not_active Expired - Lifetime
- 2001-12-11 PT PT01271999T patent/PT1345609E/pt unknown
- 2001-12-11 KR KR1020037008488A patent/KR100545906B1/ko not_active IP Right Cessation
- 2001-12-11 BR BR0116378-7A patent/BR0116378A/pt not_active IP Right Cessation
- 2001-12-11 AT AT01271999T patent/ATE297734T1/de active
- 2001-12-11 DK DK01271999T patent/DK1345609T3/da active
- 2001-12-12 US US10/020,680 patent/US6586422B2/en not_active Expired - Fee Related
- 2001-12-20 AR ARP010105926A patent/AR032379A1/es unknown
-
2003
- 2003-06-11 ZA ZA200304557A patent/ZA200304557B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60111568T2 (de) | 2006-05-11 |
| JP4077319B2 (ja) | 2008-04-16 |
| AU2002216095B2 (en) | 2005-12-01 |
| BR0116378A (pt) | 2003-10-28 |
| CA2432077C (en) | 2011-01-18 |
| KR100545906B1 (ko) | 2006-01-26 |
| ATE297734T1 (de) | 2005-07-15 |
| US20020123488A1 (en) | 2002-09-05 |
| ES2243400T3 (es) | 2005-12-01 |
| ZA200304557B (en) | 2004-09-13 |
| US6586422B2 (en) | 2003-07-01 |
| CA2432077A1 (en) | 2002-07-04 |
| AR032379A1 (es) | 2003-11-05 |
| CN1260226C (zh) | 2006-06-21 |
| PT1345609E (pt) | 2005-08-31 |
| JP2004517850A (ja) | 2004-06-17 |
| DE60111568D1 (de) | 2005-07-21 |
| EP1345609B1 (de) | 2005-06-15 |
| KR20030062444A (ko) | 2003-07-25 |
| WO2002051418A1 (en) | 2002-07-04 |
| CN1487831A (zh) | 2004-04-07 |
| EP1345609A1 (de) | 2003-09-24 |
| MXPA03005515A (es) | 2003-09-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20026125D0 (no) | Tetrahydropyridin- eller piperidin-heterocykliske derivater | |
| NO20035485L (no) | Tiofenderivater som antivirale midler for flavivirusinfeksjon | |
| MA26993A1 (fr) | 6-pyridopyrimidines substitues | |
| DE60120076D1 (de) | Schwach gefärbtes glass mit hoher durchlässigkeit | |
| DK1345609T3 (da) | Tetrahydro-(benzo eller thieno)-azepin-pyrazin- og triazinderivater som mGluR-1-antagonister | |
| DE60214428D1 (de) | 1, 4-dihydro-1, 4-diphenylpyridin-derivate | |
| NO20022573D0 (no) | N6-heterosykliske, 8-modifiserte adenosinderivater | |
| NO20013945L (no) | Fremstilling av isoflavonderivater | |
| DE60008262D1 (de) | Piperazinderivate als 5-ht1b antagonisten | |
| DE50111292D1 (de) | Neue sulfonamid-substituierte pyrazolopyridinderivate | |
| DE69930751D1 (de) | Bohrturbine | |
| HUP0202578A3 (en) | Novel derivatives of flavones, xanthones and coumarins | |
| ATE295839T1 (de) | N-(3-ethinylphenylamino)-6,7-bis(2-methoxyethox )-4-chinazolinamin-mesylat-anhydrat und -monohydrat | |
| NO20032142L (no) | Substituerte 2-fenylaminoimidazolin-fenylketon-derivater som IP-antagonister | |
| DE50015443D1 (de) | Bicyclische imidazo-5-yl-aminderivate | |
| PT1360184E (pt) | Derivados de piperidina como antagonistas da neuroquinina 1 | |
| EE200200135A (et) | D4 antagonistidena toimivad tienoisoksasolüül- jatienüülpürrasolüülfenoksü-asendatud propüülderivaadid | |
| DE50009644D1 (de) | Heterocyclisch annellierte indenochromenderivate | |
| ATE370944T1 (de) | Chromenon- und chromanonderivate als integrinhemmer | |
| DE50100383D1 (de) | H-annellierte benzo [f]chromene | |
| NO20023172L (no) | 10, 11-difluormetylendioksykamptoteciner med topoisomerase I inhibering | |
| AR028607A1 (es) | Derivados de 1,4-diazepan-2,5-diona | |
| PT1322592E (pt) | Derivados substituidos de 1-aminobutan-3-ol | |
| DK1444206T3 (da) | Substituerede benzo[b]azepin-2-on-forbindelser som analgetika | |
| ATE338043T1 (de) | 5-methoxy-8-aryl- 1,2,4ötriazolo 1,5-aöpyridine derivative als adenosin-rezeptor antagonisten |